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brest cancer

Ghada Sahraoui, Fatma Khanchel, Emna Chelbi
Breast cancer is the most common cancer among tunisian women and worldwide. In Cape Bon, Tunisia, the anatomopathological features of this cancer have not been established in previously published studies. Knowledge about these features is needed for the cultural adaptation of prevention and health care systems in the region. The aim of our study was to determine the pathological profile of breast cancers in the only public health anatomic pathology regional laboratory. We conducted a retrospective descriptive study of 116 patients who were diagnosed with breast cancers in our laboratory over a 5-year period, from July 2010 to July 2015...
2017: Pan African Medical Journal
Joséphine Zangari, Marius Ilie, Florian Rouaud, Laurie Signetti, Mickaël Ohanna, Robin Didier, Barnabé Roméo, Dana Goldoni, Nicolas Nottet, Cathy Staedel, Jocelyn Gal, Bernard Mari, Baharia Mograbi, Paul Hofman, Patrick Brest
Extracellular vesicles (EVs) have been shown to play an important role in intercellular communication as carriers of DNA, RNA and proteins. While the intercellular transfer of miRNA through EVs has been extensively studied, the stability of extracellular miRNA (ex-miRNA) once engulfed by a recipient cell remains to be determined. Here, we identify the ex-miRNA-directed phenotype to be transient due to the rapid decay of ex-miRNA. We demonstrate that the ex-miR-223-3p transferred from polymorphonuclear leukocytes to cancer cells were functional, as demonstrated by the decreased expression of its target FOXO1 and the occurrence of epithelial-mesenchymal transition reprogramming...
April 20, 2017: Nucleic Acids Research
P Šašková, D Pavlišta
OBJECTIVE: The rising number of breast cancer is the worldwide problem. The screening mammography is considered as the most effective method to decrease the mortality of the disease. For many years, the breast self-examination has been promoted as the simplest method for breast cancer development in women. In this review article, we provide the results of studies on the effectiveness of breast self-examination. DESIGN: Review article. SETTING: Departmnet of Gynecologic and Obstetrition, General Faculty Hospital and 1st Faculty of Medicine, Charles University Prague...
December 0: Ceská Gynekologie
Romain Didier, Marco A Magalhaes, Edward Koifman, Florent Leven, Philippe Castellant, Jacques Boschat, Yannic Jobic, Sarkis Kiramijyan, Pierre-Philippe Nicol, Martine Gilard
AIMS: The radiation exposure resulting from cardiovascular procedures may increase the risk of cancer, and/or cause skin injury. Whether the novel cardiovascular automated radiation reduction X-ray system (CARS) can help reduce the patient radiation dose in daily clinical practice remains unknown. The aim of this study was to evaluate the reduction in patient radiation dose with the use of CARS in the cardiac catheterisation laboratory (CCL). METHODS AND RESULTS: This study retrospectively analysed 1,403 consecutives patients who underwent a cardiac catheterisation with coronary angiography (CA) and/or a percutaneous coronary intervention (PCI) in the Brest University Hospital over the course of one year...
October 10, 2016: EuroIntervention
Sandra Lassalle, Joséphine Zangari, Alexandra Popa, Marius Ilie, Véronique Hofman, Elodie Long, Martine Patey, Frédérique Tissier, Geneviève Belléannée, Hélène Trouette, Bogdan Catargi, Isabelle Peyrottes, Jean-Louis Sadoul, Olivier Bordone, Christelle Bonnetaud, Catherine Butori, Alexandre Bozec, Nicolas Guevara, José Santini, Imène Sarah Hénaoui, Géraldine Lemaire, Olivier Blanck, Philippe Vielh, Pascal Barbry, Bernard Mari, Patrick Brest, Paul Hofman
In this study, we performed microRNA (miRNA) expression profiling on a large series of sporadic and hereditary forms of medullary thyroid carcinomas (MTC). More than 60 miRNAs were significantly deregulated in tumor vs adjacent non-tumor tissues, partially overlapping with results of previous studies. We focused our attention on the strongest up-regulated miRNA in MTC samples, miR-375, the deregulation of which has been previously observed in a variety of human malignancies including MTC. We identified miR-375 targets by combining gene expression signatures from human MTC (TT) and normal follicular (Nthy-ori 3-1) cell lines transfected with an antagomiR-375 inhibitor or a miR-375 mimic, respectively, and from an in silico analysis of thyroid cell lines of Cancer Cell Line Encyclopedia datasets...
May 24, 2016: Oncotarget
Amine Belaid, Papa Diogop Ndiaye, Harilaos Filippakis, Jérémie Roux, Éric Röttinger, Yacine Graba, Patrick Brest, Paul Hofman, Baharia Mograbi
Survival rates of patients with metastatic or recurrent cancers have remained virtually unchanged during the past 30 years. This fact makes the need for new therapeutic options even more urgent. An attractive option would be to target autophagy, an essential quality control process that degrades toxic aggregates, damaged organelles, and signaling proteins, and acts as a tumor suppressor pathway of tumor initiation. Conversely, other fascinating observations suggest that autophagy supports cancer progression, relapse, metastasis, dormancy and resistance to therapy...
2015: Current Cancer Drug Targets
Yuichi Ohgoshi, Motoi Yokozuka, Katsuyuki Terajima
BACKGROUND: Serratus-intercostal plane block (SIPB) is a novel ultrasound-guided thoracic wall nerve block reported recently. We performed SIPB for perioperative analgesia together with general anesthesia in patients undergoing partial mastectomy. METHODS: We chose the patients with breast cancer of upper to lower lateral quadrant or subareolar region. The patients received general anesthesia followed by ultrasound-guided SIPB. The needle was introduced in the midaxillary line at the level of the fourth or fifth rib...
June 2015: Masui. the Japanese Journal of Anesthesiology
Su-Ju Lee, Mary C Mahoney, Zachary Redus
After benign concordant magnetic resonance imaging (MRI)-guided breast biopsy, initial follow-up MRI at 6 months is often recommended for confirmation. This study was undertaken to determine the proper management of stable lesions on initial follow-up MRI and whether such follow-up can be safely deferred to 12 months. Retrospective review of 240 MRI-guided biopsies identified 156 benign concordant lesions. 85 eligible cases received follow-up MRI and constitute the study population. On initial follow-up MRI, 72 of 85 lesions appeared adequately sampled, 12 were stable and underwent further MRI follow-up, and 1 was benign on subsequent surgery...
November 2015: Breast Journal
F Tixier, C Cheze-Le-Rest, M Hatt, X Dufour, G Valette, G Potard, L Corcos, D Visvikis
PURPOSE: Several quantitative features can be extracted from 18F-FDG PET images, such as standardized uptake values (SUVs), metabolic tumor volume (MTV), shape characterization (SC) or intra-tumor radiotracer heterogeneity quantification (HQ). Some of these features calculated from baseline 18F-FDG PET images have shown a prognostic and predictive clinical value. It has been hypothesized that these features highlight underlying tumor patho-physiological processes at smaller scales. The objective of this study was to investigate the ability of recovering alterations of signaling pathways from FDG PET image-derived features...
June 2015: Medical Physics
N Guibert, M Ilie, E Long, V Hofman, L Bouhlel, P Brest, B Mograbi, C H Marquette, A Didier, J Mazieres, P Hofman
KRAS mutations are detected in over one third of lung adenocarcinomas, most frequently in Caucasian and smoker patients. The impact of KRAS mutations on lung adenocarcinoma prognosis is currently subject to debate, as is their impact on the response to chemotherapy and EGFR tyrosine kinase inhibitors. The different methods for KRAS status assessment, based on histological and cytological samples or biological fluids, offer varying sensitivities. Since no treatments are available in clinical routine for KRAS-mutated lung cancer patients, one of the current major challenges in thoracic oncology is developing new dedicated strategic therapies...
2015: Current Molecular Medicine
G Yordanov, S Gorchev, N Tomov, Hinkova
Endometrial canceris the most common gynaecological malignancy after brest cancer. The lymph node status is with great prognostic value and it is important for postoperative treatment and survival. That is why it is looking for methods giving information for the lymph node status and not increasing postoperative complications.
2014: Akusherstvo i Ginekologii︠a︡
Michela Andretta, Serena Scomersi, Monica Urbani, Marina Bortul
AIM: Evaluation of therapeutic strategy for Ductal Carcinoma In Situ (DCIS) patients at our Brest Cancer Centre and analysis of our pattern of treatment with respect to Van Nuys Prognostic Index (VNPI) cathegories. MATHERIAL OF STUDY: Our study population is the result of a selection of 85 DCIS patients classified according to the VNPI risk of Local Recurrence (LR). A comparison was made between treatment effectively performed and therapy suggested by VNPI protocols...
May 2014: Annali Italiani di Chirurgia
Didier Bechlian, Amélie Honstettre, Michèle Terrier, Christelle Brest, Carine Malenfant, Marie-Joëlle Mozziconacci, Christian Chabannon
Scientific studies in oncology, cancer diagnosis, and monitoring tumor response to therapeutics currently rely on a growing number of clinico-pathological information. These often include molecular analyses. The quality of these analyses depends on both pre-analytical and analytical information and often includes the extraction of DNA and/or RNA from human tissues and cells. The quality and quantity of obtained nucleic acids are of utmost importance. The use of automated techniques presents several advantages over manual techniques, such as reducing technical time and thus cost, and facilitating standardization...
June 2009: Biopreservation and Biobanking
Hanan Osman-Ponchet, Anais Boulai, Magali Kouidhi, Karine Sevin, Marion Alriquet, Alexandre Gaborit, Béatrice Bertino, Pierre Comby, Bernard Ruty
BACKGROUND: Most identified drug transporters belong to the ATP-binding cassette (ABC) and solute carrier (SLC) families. Recent research indicates that these transporters play an important role in the absorption, distribution and excretion of drugs, and are involved in clinically relevant drug-drug interactions for systemic drugs. However, very little is known about the role of drug transporters in human skin, especially in the disposition of topically applied drugs, and their involvement in drug-drug interactions...
2014: Drug Metabolism and Drug Interactions
Laura Bonanno, Adolfo Favaretto, Rafael Rosell
The standard first-line treatment for around 80% of newly-diagnosed advanced non-small cell lung cancer (NSCLC) is chemotherapy. Currently, patients are allocated to chemotherapy on the basis of clinical conditions, comorbidities and histology. If feasible, platinum-based chemotherapy is considered as the most efficacious option. Due to the heterogeneity in terms of platinum-sensitivity among patients with NSCLC, great efforts have been made in order to identify molecular predictive markers of platinum resistance...
January 2014: Anticancer Research
Amine Belaid, Papa Diogop Ndiaye, Michaël Cerezo, Laurence Cailleteau, Patrick Brest, Daniel J Klionsky, Georges F Carle, Paul Hofman, Baharia Mograbi
Degradation of signaling proteins is one of the most powerful tumor-suppressive mechanisms by which a cell can control its own growth, its survival, and its motility. Emerging evidence suggests that autophagy limits several signaling pathways by degrading kinases, downstream components, and transcription factors; however, this often occurs under stressful conditions. Our recent studies revealed that constitutive autophagy temporally and spatially controls the RHOA pathway. Specifically, inhibition of autophagosome degradation induces the accumulation of the GTP-bound form of RHOA...
February 2014: Autophagy
L Večeřová, M Bendová
DESIGN: This is a retrospective study evaluating the minimum detection cancers in the group of women mammographically examined in our department. The study covers the period from 1. 1. 2012 to 31. 12. 2012. Interestingly we introduced several interesting case studies. OBJECTIVE: 1. Confirmation upward trend in the number of minimal breast cancers, stage T1. 2. The need for multidisciplinary cooperation for quick minimal surgical intervention and effective cancer treatment...
August 2013: Ceská Gynekologie
Marius Ilie, Véronique Hofman, Joséphine Zangari, Johanna Chiche, Jérôme Mouroux, Nathalie M Mazure, Jacques Pouysségur, Patrick Brest, Paul Hofman
The disorganized neo-vasculature in tumours causes fluctuations in the concentration of oxygen, which contributes to tumour development and metastatic potential. Although hypoxic regulation of the expression of the carbonic anhydrases CAIX and CAXII is well established, the effect of re-oxygenation on these proteins remains to be elucidated. A549 and H1975 human lung cancer cell lines were exposed to hypoxia for 24 h and then re-oxygenated. CAIX or CAXII expression and cell cycle progression at different time-points were monitored...
October 2013: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Amine Belaid, Michaël Cerezo, Abderrahman Chargui, Elisabeth Corcelle-Termeau, Florence Pedeutour, Sandy Giuliano, Marius Ilie, Isabelle Rubera, Michel Tauc, Sophie Barale, Corinne Bertolotto, Patrick Brest, Valérie Vouret-Craviari, Daniel J Klionsky, Georges F Carle, Paul Hofman, Baharia Mograbi
Degradation of signaling proteins is one of the most powerful tumor-suppressive mechanisms by which a cell can control its own growth. Here, we identify RHOA as the molecular target by which autophagy maintains genomic stability. Specifically, inhibition of autophagosome degradation by the loss of the v-ATPase a3 (TCIRG1) subunit is sufficient to induce aneuploidy. Underlying this phenotype, active RHOA is sequestered via p62 (SQSTM1) within autolysosomes and fails to localize to the plasma membrane or to the spindle midbody...
July 15, 2013: Cancer Research
Jorge Llenas, Anahí Bringas, Jimena Nocito, Susana Gómez Zanni, Ricardo Campana, Mariana Papa
We report the case of a caucasian woman of 44 years old with no personal medical history. She was diagnosed breast carcinoma and underwent right partial mastectomy with adjuvant radiotherapy and chemotherapy. Four years after the intervention, presented a indurated plaque. Biopsy was performed and the diagnosis of morpheawas confirmed by histopathological examination.
2012: Revista de la Facultad de Ciencias Médicas
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