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https://www.readbyqxmd.com/read/29771050/-fibrous-hemangioma-of-esophagus-portal-a-case-report
#1
Y P Wang, L X Li
A 33 year old male patient has found in the oral cavity tumor with nausea and vomiting after 20 days ago. The patients feel pharyngeal foreign body sensation, occasional sense of suffocation, the oropharyngeal tumor disappeared and foreign body sensation disappeared after swallowing. The patients without angina, no hemoptysis, no hoarseness, no acid reflux symptoms and weight loss phenomenon. The gastroscope showed giant tumor, esophagus smooth surface, visible local gray blue blood vessels, from the entrance of esophagus has been extended to the esophagus from the upper incisors 25 cm...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29765420/a-feasible-method-of-angiogenesis-assessment-in-gastric-cancer-using-3d-microvessel-density
#2
Lu Zhang, Fei Zheng, Zhigang Peng, Zijing Hu, Zhi Yang
Background: Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to present a method for improved angiogenesis assessment. Methods: We proposed a three-dimensional microvessel density (3D MVD) to evaluate tumor angiogenesis and tested it in animal models...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29752717/tumor-progression-and-metastatic-dissemination-in-ovarian-cancer-after-dose-dense-or-conventional-paclitaxel-and-cisplatin-plus-bevacizumab
#3
Francesca Bizzaro, Francesca Falcetta, Elisa D'Agostini, Alessandra Decio, Lucia Minoli, Eugenio Erba, Fedro Alessandro Peccatori, Eugenio Scanziani, Nicoletta Colombo, Massimo Zucchetti, MariaRosa Bani, Paolo Ubezio, Raffaella Giavazzi
The efficacy of therapeutic regimens incorporating weekly or every-3-weeks paclitaxel (PTX) for ovarian cancer is debated. We investigated the addition of bevacizumab in regimens of chemotherapy with different PTX doses and schedules in preclinical models. Treatments were cisplatin (DDP) with weekly PTX (conventional), or dose-dense-equi (every other day to the conventional cumulative dose), or dose-dense-high (total dose 1.5 times higher), with or without bevacizumab. Treatment efficacy was evaluated analyzing tumor growth in different time-windows in two patient-derived ovarian cancer xenografts with different sensitivity to cisplatin...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29749489/effects-of-osteoprotegerin-tnfrsf11b-in-two-models-of-abdominal-aortic-aneurysms
#4
Emina Vorkapic, Anne Kunath, Dick Wågsäter
Osteoprotegerin (OPG), additionally termed tumor necrosis factor receptor superfamily member 11B, is produced by vascular smooth muscle cells (VSMCs) and endothelial cells in the vasculature, and its release may be modulated by pro‑inflammatory cytokines, including interleukin‑1β and tumor necrosis factor‑α. The present study investigated the effects of treatment with low‑dose human recombinant OPG on abdominal aortic aneurysm (AAA) development in mice. Mice were treated with 1 µg human recombinant OPG four times (or vehicle) for 2 weeks prior to inducing AAA...
April 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29731903/overexpression-of-mmp21-and-mmp28-is-associated-with-gastric-cancer-progression-and-poor-prognosis
#5
Jizhen Zhang, Qi Pan, Wenhui Yan, Yiru Wang, Xujun He, Zhongsheng Zhao
Matrix metalloproteinase (MMP)-21 and MMP-28, or epilysin, are overexpressed during the invasion and metastasis of solid tumors. The present study investigated MMP-21 and MMP-28 expression levels in human gastric cancer using tissue microarray (TMA) analysis, and determined their association with clinicopathological characteristics and patient prognosis. TMA blocks, including 436 cases of gastric cancer and 92 non-cancerous adjacent gastric tissues, were investigated using immunohistochemistry. Staining results were analyzed statistically in association with various clinicopathological characteristics and overall survival...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29730154/histidine-rich-glycoprotein-induced-vascular-normalization-improves-epr-mediated-drug-targeting-to-and-into-tumors
#6
Benjamin Theek, Maike Baues, Felix Gremse, Robert Pola, Michal Pechar, Inka Negwer, Kaloian Koynov, Benjamin Weber, Matthias Barz, Willi Jahnen-Dechent, Gert Storm, Fabian Kiessling, Twan Lammers
Tumors are characterized by leaky blood vessels, and by an abnormal and heterogeneous vascular network. These pathophysiological characteristics contribute to the enhanced permeability and retention (EPR) effect, which is one of the key rationales for developing tumor-targeted drug delivery systems. Vessel abnormality and heterogeneity, however, which typically result from excessive pro-angiogenic signaling, can also hinder efficient drug delivery to and into tumors. Using histidine-rich glycoprotein (HRG) knockout and wild type mice, and HRG-overexpressing and normal t241 fibrosarcoma cells, we evaluated the effect of genetically induced and macrophage-mediated vascular normalization on the tumor accumulation and penetration of ~10-20 nm-sized polymeric drug carriers based on poly(N-(2-hydroxypropyl) methacrylamide)...
May 3, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29717026/steroid-receptor-coactivator-1-interacts-with-nf-%C3%AE%C2%BAb-to-increase-the-vegfc-level-in-human-thyroid-cancer
#7
Bo Gao, Lingji Guo, Donglin Luo, Yan Jiang, Jianjie Zhao, Chengyi Mao, Yan Xu
Thyroid cancer is the most common endocrine cancer, and has a high incidence of lymphatic metastasis. Vascular endothelial growth factor C (VEGFC) is essential for development of lymphatic vessels and lymphatic metastases during carcinogenesis. Steroid receptor coactivator-1 (SRC-1) interacts with nuclear receptors and transcription factors to promote tumor proliferation and metastasis. However, the correlation between SRC-1 and VEGFC levels in the lymphatic metastases of thyroid cancer remains unclear. We analyzed 20 paired specimens of thyroid cancer tissue and normal thyroid tissue and found increased levels of SRC-1 and VEGFC proteins in 13/20 and 15/20 thyroid cancer specimens, respectively, when compared with those levels in specimens of normal thyroid tissue...
May 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29697927/robotic-excision-of-complex-adrenal-mass-with-retrocaval-extension-and-encasement-of-renal-hilum-with-renal-preservation
#8
Vishnu Raveendran, Ramaprasad Manasseri Koduveli, Kishore Thekke Adiyat
OBJECTIVE: The purpose of this video is to present robotic excision of a complex adrenal mass with retrocaval extension and encasement of renal hilum in a 16 year old boy. Biochemical screening was negative for metabolically active component. Computerized tomographic scan with contrast revealed a homogenous mass of approximately 10.8 cm x 6.2 cm x 4.2 cm in the suprarenal area on right side that was extend-ing behind inferior vena cava and encasing renal hilar vessels. Imaging findings were that of a classical ganglioneuroma...
April 5, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29695087/contribution-of-tumor-endothelial-cells-in-cancer-progression
#9
REVIEW
Kyoko Hida, Nako Maishi, Dorcas A Annan, Yasuhiro Hida
Tumor progression depends on the process of angiogenesis, which is the formation of new blood vessels. These newly formed blood vessels supply oxygen and nutrients to the tumor, supporting its progression and providing a gateway for tumor metastasis. Tumor angiogenesis is regulated by the balance between angiogenic activators and inhibitors within the tumor microenvironment. Because the newly formed tumor blood vessels originate from preexisting normal vessels, tumor blood vessels, and tumor endothelial cells (TECs) have historically been considered to be the same as normal blood vessels and endothelial cells; however, evidence of TECs’ distinctive abnormal phenotypes has increased...
April 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29690962/effectiveness-of-vascular-markers-immunohistochemical-stains-in-soft-tissue-sarcomas
#10
Namra Naeem, Sajid Mushtaq, Noreen Akhter, Mudassar Hussain, Usman Hassan
OBJECTIVE: To ascertain the effectiveness of IHC markers of vascular origin like CD31, CD34, FLI1 and ERG in vascular soft tissue sarcomas including angiosarcomas, Kaposi sarcomas, epithelioid hemangioendothelioma and a non-vascular soft tissue sarcoma (Epithelioid sarcoma). STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from 2011 to 2017. METHODOLOGY: Diagnosed cases of angiosarcomas (n=48), epithelioid hemangioendothelioma (n=9), Kaposi sarcoma (n=9) and epithelioid sarcoma (n=20) were selected...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29690504/selective-inhibition-of-histone-deacetylation-in-melanoma-increases-targeted-gene-delivery-by-a-bacteriophage-viral-vector
#11
Samuel Campbell, Keittisak Suwan, Sajee Waramit, Eric Ofori Aboagye, Amin Hajitou
The previously developed adeno-associated virus/phage (AAVP) vector, a hybrid between M13 bacteriophage (phage) viruses that infect bacteria only and human Adeno-Associated Virus (AAV), is a promising tool in targeted gene therapy against cancer. AAVP can be administered systemically and made tissue specific through the use of ligand-directed targeting. Cancer cells and tumor-associated blood vessels overexpress the αν integrin receptors, which are involved in tumor angiogenesis and tumor invasion...
April 21, 2018: Cancers
https://www.readbyqxmd.com/read/29683458/isolation-of-human-endothelial-cells-from-normal-colon-and-colorectal-carcinoma-an-improved-protocol
#12
Elisabeth Naschberger, Daniela Regensburger, Clara Tenkerian, Melanie Langheinrich, Felix B Engel, Carol Geppert, Arndt Hartmann, Robert Grützmann, Vera S Schellerer, Michael Stürzl
Primary cells isolated from human carcinomas are valuable tools to identify pathogenic mechanisms contributing to disease development and progression. In particular, endothelial cells (EC) constituting the inner surface of vessels, directly participate in oxygen delivery, nutrient supply, and removal of waste products to and from tumors, and are thereby prominently involved in the constitution of the tumor microenvironment (TME). Tumor endothelial cells (TECs) can be used as cellular biosensors of the intratumoral microenvironment established by communication between tumor and stromal cells...
April 4, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29682029/meningioma-consistency-correlation-between-magnetic-resonance-imaging-characteristics-operative-findings-and-histopathological-features
#13
Mahmoud Alyamany, Mohammad M Alshardan, Abdullah Abu Jamea, Nahid ElBakry, Lahbib Soualmi, Yasser Orz
Introduction: Intracranial meningiomas account for 30% of all primary intracranial tumors. Surgical resection remains the mainstay of the treatment for meningiomas. The magnetic resonance of intracranial meningiomas has been largely discussed in many reports of the radiological and neurosurgical literature. To date, a few studies have been attempted to differentiate the tumor characteristics of meningiomas based on magnetic resonance imaging (MRI) studies. Objective: The objective of the study is to evaluate the relationship between MRI signal characteristics of intracranial meningiomas and consistency of tumor using objective measures...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29678849/effects-of-adenovirus-mediated-vegf165-gene-therapy-on-myocardial-infarction
#14
Chao Wang, Boya Zhang, Yu Lin, Yang Dong
AIM: To evaluate the role of adenovirus-mediated transduction human VEGF isoform 165 via direct myocardial injection in rats with an occluded circumflex coronary artery, and the possible underlying mechanism. METHODS: Sprague-Dawley rats were induced myocardial infarction (MI) with ligation of the left coronary artery. Rats were randomly divided into 4 groups: 1) the sham group; 2) the MI group; 3) the NS (normal saline) group and 4) the VEGF group. Direct myocardial injection of 0...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29662195/ngr-asn-gly-arg-targeted-delivery-of-coagulase-to-tumor-vasculature-arrests-cancer-cell-growth
#15
Khaled Seidi, Rana Jahanban-Esfahlan, Hassan Monhemi, Peyman Zare, Babak Minofar, Amir Daei Farshchi Adli, Davoud Farajzadeh, Ramezan Behzadi, Mehran Mesgari Abbasi, Heidi A Neubauer, Richard Moriggl, Nosratollah Zarghami, Tahereh Javaheri
Induction of selective thrombosis and infarction in tumor-feeding vessels represents an attractive strategy to combat cancer. Here we took advantage of the unique coagulation properties of staphylocoagulase and genetically engineered it to generate a new fusion protein with novel anti-cancer properties. This novel bi-functional protein consists of truncated coagulase (tCoa) and an NGR (GNGRAHA) motif that recognizes CD13 and αv β3 integrin receptors, targeting it to tumor endothelial cells. Herein, we report that tCoa coupled by its C-terminus to an NGR sequence retained its normal binding activity with prothrombin and av β3 integrins, as confirmed in silico and in vitro...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29651419/management-of-glioblastoma-multiforme-in-a-patient-treated-with-ketogenic-metabolic-therapy-and-modified-standard-of-care-a-24-month-follow-up
#16
Ahmed M A Elsakka, Mohamed Abdel Bary, Eman Abdelzaher, Mostafa Elnaggar, Miriam Kalamian, Purna Mukherjee, Thomas N Seyfried
Few advances have been made in overall survival for glioblastoma multiforme (GBM) in more than 40 years. Here, we report the case of a 38-year-old man who presented with chronic headache, nausea, and vomiting accompanied by left partial motor seizures and upper left limb weakness. Enhanced brain magnetic resonance imaging revealed a solid cystic lesion in the right partial space suggesting GBM. Serum testing revealed vitamin D deficiency and elevated levels of insulin and triglycerides. Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29650228/visualization-of-proliferative-vascular-endothelial-cells-in-tumors-in-vivo-by-imaging-their-partner-of-sld5-1-promoter-activity
#17
Daishi Yamakawa, Weizhen Jia, Hiroyasu Kidoya, Shoko Hosojima, Miku Torigata, Li Zhang, Nobuyuki Takakura
Vascular endothelial cells (ECs) isolated from tumors characteristically express certain genes. It has recently been suggested that tumor vessel normalization facilitates effective drug delivery into tumors; however, how tumor vessel normalization can be recognized on the basis of the molecules expressed by tumor ECs is not clearly defined. The degree of cell proliferation is an important indicator to characterize the condition of the ECs. Herein, we generated transgenic mice expressing enhanced green fluorescent protein (EGFP) under the transcriptional control of the DNA replication factor partner of Sld5-1 (PSF1; official name GINS1) promoter to assess whether active ECs can be distinguished from dormant ECs...
April 2, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29626124/in-vivo-characterization-of-four-68-ga-labeled-multimeric-rgd-peptides-to-image-%C3%AE-v-%C3%AE-3-integrin-expression-in-two-human-tumor-xenograft-mouse-models
#18
Daphne Lobeek, Gerben M Franssen, Michelle T Ma, Hans-Jürgen Wester, Clemens Decristoforo, Wim J G Oyen, Otto C Boerman, Samantha Y A Terry, Mark Rijpkema
Rationale: αv β3 integrins play an important role in angiogenesis and cell migration of cancers. They are highly expressed on activated endothelial cells of newly formed blood vessels. Here, we compare the targeting characteristics of four68 Ga-labeled multimeric cyclic arginine-glycine-aspartate RGD-based tracers in an αv β3 integrin-expressing tumor model and in a tumor model where αv β3 integrin is expressed solely on the neovasculature. Methods: Female BALB/c nude mice were subcutaneously injected with SK-RC-52 (αv β3 integrin-positive) or FaDu (αv β3 integrin-negative) tumor cells...
April 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29620183/puerarin-regulates-neovascular-glaucoma-through-pigment-epithelium%C3%A2-derived-growth-factor%C3%A2-induced-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway
#19
Hui-Yu Wei, Ya-Jie Zhang, Shao-Zhen Zhao
Neovascular glaucoma is an ophthalmic disease and a potentially blinding secondary glaucoma caused by the formation of abnormal new blood vessels on the iris, which can prevent the normal drainage of water from the anterior segment of the eye. Evidence from China has suggested that puerarin benefits many diseases including myocardial infarction, stable angina, cerebral ischemia and glaucoma in a clinical setting. In the present study, the aim was to investigate the efficacies of puerarin on neovascular glaucoma in a mouse model...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29618124/microsurgical-resection-of-a-large-intraventricular-trigonal-tumor-3-dimensional-operative-video
#20
Chun-Yu Cheng, Rakshith Shetty, Laligam N Sekhar
A 62-yr-old woman presented with incidentally detected left trigonal mass by magnetic resonance imaging (MRI) performed during workup for left-sided hearing loss and vertigo of 5-yr duration. Due to persistent dizziness, headache, and progressive enlargement of the tumor in follow-up scans, operation was planned. Because the tumor extended superiorly, a superior parietal lobule approach was selected.She underwent a left parietal craniotomy. A strip electrode was used to localize the motor and sensory regions, and neuronavigation was used to confirm the entry site...
March 30, 2018: Operative Neurosurgery (Hagerstown, Md.)
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