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Tumor vessel normalization

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https://www.readbyqxmd.com/read/28527400/effects-of-combretastatin-a-4-phosphate-on-canine-normal-and-tumor-tissue-derived-endothelial-cells
#1
Yusuke Izumi, Keisuke Aoshima, Yuki Hoshino, Satoshi Takagi
Combretastatin A-4 phosphate (CA4P) selectively blocks tumor blood flow. However, the detailed mechanisms through which CA4P specifically affects tumor blood vessels are not well understood. Recent reports revealed that tumor tissue-derived endothelial cells (TECs) have various specific features in comparison with normal tissue-derived endothelial cells (NECs). Thus, abnormalities in TECs may be involved in the selective vascular blockade mechanism of CA4P. In this study, we evaluated the effects of CA4P on canine NECs and TECs using confocal microscopy...
May 13, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28514684/cd4-t-cell-activation-and-vascular-normalization-two-sides-of-the-same-coin
#2
Michele De Palma, Rakesh K Jain
Normalization of tumor blood vessels enhances the infiltration and functions of T cells. Tian et al. (2017) report that effector CD4(+) T cells, in turn, support vascular normalization, highlighting intertwined roles for blood vessels and T cells in cancer.
May 16, 2017: Immunity
https://www.readbyqxmd.com/read/28511237/performance-of-a-fully-disposable-digital-single-operator-cholangiopancreatoscope
#3
Raj J Shah, Isaac Raijman, Brian Brauer, Bora Gumustop, Douglas K Pleskow
Background and study aim Our aim was to evaluate the first use in humans of a new, single-use, digital, single-operator intraductal cholangiopancreatoscopy system (IDCP). Patients and methods Data were collected retrospectively from four US institutions between February 2015 and April 2015. The visual impression of neoplasia or benign findings with IDCP was determined by the performing endoscopist. High grade dysplasia, intraductal papillary mucinous neoplasm, neuroendocrine tumor, and malignancy were categorized as neoplasia...
May 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/28508297/adaptation-to-stochastic-temporal-variations-in-intratumoral-blood-flow-the-warburg-effect-as-a-bet-hedging-strategy
#4
Curtis A Gravenmier, Miriam Siddique, Robert A Gatenby
While most cancers promote ingrowth of host blood vessels, the resulting vascular network usually fails to develop a mature organization, resulting in abnormal vascular dynamics with stochastic variations that include slowing, cessation, and even reversal of flow. Thus, substantial spatial and temporal variations in oxygen concentration are commonly observed in most cancers. Cancer cells, like all living systems, are subject to Darwinian dynamics such that their survival and proliferation are dependent on developing optimal phenotypic adaptations to local environmental conditions...
May 15, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28500279/new-navigation-surgery-for-resection-of-lymphatic-malformations-using-indocyanine-green-fluorescence-imaging
#5
Chiyoe Shirota, Akinari Hinoki, Masataka Takahashi, Yujiro Tanaka, Takahisa Tainaka, Wataru Sumida, Naruhiko Murase, Kazuo Oshima, Ryo Shirotsuki, Kosuke Chiba, Yuji Morimoto, Hiroo Uchida
BACKGROUND We used indocyanine green (ICG) fluorescence imaging to completely resect lymphatic malformations (LMs). This is the first report of navigation surgery utilizing ICG fluorescence imaging for resection of LMs. CASE REPORT A 15-year-old boy was diagnosed with LMs in the abdominal wall. The extent of the tumor was determined by an ultrasound, and ICG (Diagnogreen®, Daiichi-Sankyo Pharma, Tokyo, Japan) was injected subcutaneously and intradermally into the core and 2 marginal regions of the tumor (3 injections in total), respectively...
May 13, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28499275/effects-of-microrna-126-on-cell-proliferation-apoptosis-and-tumor-angiogenesis-via-the-down-regulating-erk-signaling-pathway-by-targeting-egfl7-in-hepatocellular-carcinoma
#6
Cheng Gong, Jing Fang, Guang Li, Han-Han Liu, Zhi-Su Liu
This study intends to explore the effects of microRNA-126 (miR-126) on cell proliferation, apoptosis, and tumor angiogenesis in hepatocellular carcinoma (HCC) by regulating epidermal growth factor-like domain 7 (EGFL7) through extracellular signal-regulated kinase (ERK) signaling. HCC tissues and adjacent normal tissues were obtained from 184 HCC patients. HCC cells were separately transfected with recombinant plasmids. Western blotting and qRT-PCR were applied to detect miR-126 and EGFL7, ERK, Fas/FasL, Bcl-2, Caspase mRNA and protein levels...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28496326/gold-nanoparticles-attenuate-metastasis-by-tumor-vasculature-normalization-and-epithelial-mesenchymal-transition-inhibition
#7
Wei Li, Xin Li, Shuhao Liu, Wende Yang, Fan Pan, Xiao-Yan Yang, Bin Du, Li Qin, Yunlong Pan
Angiogenesis is a process by which vessels are formed through preexisting ones, and this plays a key role in the progression of solid tumors. However, tumor vessels are influenced by excessive pro-angiogenic factors, resulting in deformed structures that facilitate the intravasation of tumor cells into the circulation and subsequent metastasis. Moreover, abnormal tumor vessels have low blood perfusion and thereby decreased oxygen infusion into tumors. This results in a hostile microenvironment that promotes epithelial-mesenchymal transition (EMT), a process in which epithelial cells lose their polarity and gain increased motility, which is associated with metastasis and invasion...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28492341/implications-of-neurovascular-uncoupling-in-functional-magnetic-resonance-imaging-fmri-of-brain-tumors
#8
Rebecca W Pak, Darian H Hadjiabadi, Janaka Senarathna, Shruti Agarwal, Nitish V Thakor, Jay J Pillai, Arvind P Pathak
Functional magnetic resonance imaging (fMRI) serves as a critical tool for presurgical mapping of eloquent cortex and changes in neurological function in patients diagnosed with brain tumors. However, the blood-oxygen-level-dependent (BOLD) contrast mechanism underlying fMRI assumes that neurovascular coupling remains intact during brain tumor progression, and that measured changes in cerebral blood flow (CBF) are correlated with neuronal function. Recent preclinical and clinical studies have demonstrated that even low-grade brain tumors can exhibit neurovascular uncoupling (NVU), which can confound interpretation of fMRI data...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28489706/optical-coherence-tomography-angiography-of-congenital-simple-hamartoma-of-the-retinal-pigment-epithelium
#9
Parnian Arjmand, Elizabeth B Elimimian, Emil A T Say, Carol L Shields
PURPOSE: To describe the optical coherence tomography angiography features of congenital simple hamartoma of the retinal pigment epithelium. METHODS: Case report. RESULTS: A 14-year-old boy was referred for an asymptomatic fundus tumor in the left eye. Visual acuity was 20/20 in the right eye and 20/40 in the left eye. The right fundus was normal. The left fundus disclosed a gray-white nodular retinal mass of 2-mm diameter in the juxtafoveal region, protruding into the vitreous cavity and causing radial retinal folds...
May 9, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28487985/gardenia-jasminoides-has-therapeutic-effects-on-l%C3%A2-nna%C3%A2-induced-hypertension-in%C3%A2-vivo
#10
Shaocheng Chen, Peng Sun, Xin Zhao, Ruokun Yi, Jun Qian, Yanhong Shi, Rui Wang
Gardenia jasminoides is a plant that has been used in traditional Chinese medicine. It has four key active components (genipin gentiobioside, geniposide, crocin 1 and crocin 2). The aim of the present study was to determine the anti‑hypertension effects of Gardenia jasminoidesin vivo. The chemical composition of Gardenia jasminoides was determined using liquid chromatography. The anti‑hypertensive effects of Gardenia jasminoides were determined by a L‑NG‑nitroarginine (L‑NNA)‑induced hypertension animal model...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28486399/assessment-of-heparanase-mediated-angiogenesis-using-microvascular-endothelial-cells-identification-of-%C3%AE-carrageenan-derivative-as-a-potent-anti-angiogenic-agent
#11
Nicolas Poupard, Pamela Badarou, Fabienne Fasani, Hugo Groult, Nicolas Bridiau, Frédéric Sannier, Stéphanie Bordenave-Juchereau, Claudine Kieda, Jean-Marie Piot, Catherine Grillon, Ingrid Fruitier-Arnaudin, Thierry Maugard
Heparanase is overexpressed by tumor cells and degrades the extracellular matrix proteoglycans through cleavage of heparan sulfates (HS), allowing pro-angiogenic factor release and thus playing a key role in tumor angiogenesis and metastasis. Here we propose new HS analogs as potent heparanase inhibitors: Heparin as a positive control, Dextran Sulfate, λ-Carrageenan, and modified forms of them obtained by depolymerization associated to glycol splitting (RD-GS). After heparanase activity assessment, 11 kDa RD-GS-λ-Carrageenan emerged as the most effective heparanase inhibitor with an IC50 of 7...
May 9, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28481809/vessel-masked-perfusion-magnetic-resonance-imaging-with-histogram-analysis-improves-diagnostic-accuracy-for-the-grading-of-glioma
#12
Atsuko Arisawa, Yoshiyuki Watanabe, Hisashi Tanaka, Hiroto Takahashi, Chisato Matsuo, Takuya Fujiwara, Yasunori Fujimoto, Kouji Yamamoto, Noriyuki Tomiyama
OBJECTIVE: Dynamic susceptibility contrast magnetic resonance imaging is widely used to assess glioma grade; histogram analyses are used for precise tumor perfusion evaluations. We evaluated the effect of vessel contamination in normalized cerebral blood volume (nCBV) to differentiate high- and low-grade gliomas. METHODS: Thirty-four patients with gliomas underwent dynamic susceptibility contrast magnetic resonance imaging. Both traditional and vessel-masked nCBV maps were constructed...
May 6, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28469004/sprouting-strategies-and-dead-ends-in-anti-angiogenic-targeting-of-nets
#13
Patricia Carrasco, Iratxe Zuazo-Gaztelu, Oriol Casanovas
Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that arise from cells of the neuroendocrine system. NETs are characterized by being highly vascularized tumors that produce large amounts of proangiogenic factors. Due to their complexity and heterogeneity, progress in the development of successful therapeutic approaches has been limited. For instance, standard chemotherapy-based therapies have proven to be poorly selective for tumor cells and toxic for normal tissues. Considering the urge to develop an efficient therapy to treat NET patients, vascular targeting has been proposed as a new approach to block tumor growth...
May 3, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28467098/imaging-features-of-primary-renal-lymphoma
#14
Qingqiang Zhu, Wenrong Zhu, Jingtao Wu, Wenxin Chen
Background Cases of primary renal lymphoma (PRL) are quite rare and are often mistaken for renal cell carcinoma. Purpose To determine the multislice computed tomography (MSCT) and magnetic resonance imaging (MRI) characteristics of PRL. Materials and Methods Twenty-three patients with PRL were identified by CT and MRI, and their tumor characteristics were assessed. Results Tumors exhibited single or multifocal nodules (n = 19) and diffuse renal enlargement (n = 4). Twenty-two tumors exhibited an infiltrative appearance...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28465464/inflammatory-signals-from-photoreceptor-modulate-pathological-retinal-angiogenesis-via-c-fos
#15
Ye Sun, Zhiqiang Lin, Chi-Hsiu Liu, Yan Gong, Raffael Liegl, Thomas W Fredrick, Steven S Meng, Samuel B Burnim, Zhongxiao Wang, James D Akula, William T Pu, Jing Chen, Lois E H Smith
Pathological neovessels growing into the normally avascular photoreceptors cause vision loss in many eye diseases, such as age-related macular degeneration and macular telangiectasia. Ocular neovascularization is strongly associated with inflammation, but the source of inflammatory signals and the mechanisms by which these signals regulate the disruption of avascular privilege in photoreceptors are unknown. In this study, we found that c-Fos, a master inflammatory regulator, was increased in photoreceptors in a model of pathological blood vessels invading photoreceptors: the very low-density lipoprotein receptor-deficient (Vldlr(-/-) ) mouse...
May 2, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28461759/relationship-between-computed-tomography-morphology-and-prognosis-of-patients-with-stage-i-non-small-cell-lung-cancer
#16
Jun Ma, Yun-Long Yang, Ye Wang, Xue-Wei Zhang, Xue-Song Gu, Zhen-Chang Wang
This study aimed to explore the relationship between computed tomography morphology and prognosis of patients with stage I non-small cell lung cancer (NSCLC). From May 2009 to May 2011, a total of 124 patients diagnosed with stage I NSCLC were included. All patients had complete chest computed tomography scans. Five-year follow-up was conducted. Univariate and multivariate Cox regression analyses were performed to estimate the prognostic factors for patients with stage I NSCLC. The 5-year survival rate was 67...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28445938/pirfenidone-normalizes-the-tumor-microenvironment-to-improve-chemotherapy
#17
Christiana Polydorou, Fotios Mpekris, Panagiotis Papageorgis, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion and thus, improve drug delivery and the efficacy of cancer therapy. Therefore, we now need to identify safe and well tolerated pharmaceutical agents that are able to remodel the microenvironment of solid tumors and enhance chemotherapy. In this study, we repurposed Pirfenidone, a clinically approved anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis, to investigate its possible role on tumor microenvironment normalization...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28441526/it-s-t-time-for-normal-blood-vessels
#18
Bernard Thienpont, Diether Lambrechts
In a new report in Nature, Tian and colleagues (2017) describe that T cell activation in tumors induces blood vessel normalization. Because abnormal vasculature in tumors is known to reduce chemotherapy effectiveness and T lymphocyte infiltration and to increase metastasis, this suggests an exciting novel angle for checkpoint immunotherapy.
April 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28432590/pathological-analysis-of-the-surgical-margins-of-resected-glioblastomas-excised-using-photodynamic-visualization-with-both-5-aminolevulinic-acid-and-fluorescein-sodium
#19
Hirohito Yano, Noriyuki Nakayama, Naoyuki Ohe, Kazuhiro Miwa, Jun Shinoda, Toru Iwama
During glioma resection, 5-aminolevulinic acid (5-ALA) and fluorescein sodium (Fl-Na) are used for photodynamic tumor visualization. The objective of this study was to evaluate the pathological findings of the boundary zone between the tumor and adjacent normal brain in glioblastoma patients undergoing simultaneous double staining with 5-ALA and Fl-Na during surgery. Eight patients received 5-ALA (20 mg/kg orally) before the induction of general anesthesia, and Fl-Na (20 mg/kg) was administered intravenously before the dural incision was performed...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28432469/renal-findings-in-patients-with-mulibrey-nanism
#20
Johanna Sivunen, Susann Karlberg, Jouko Lohi, Niklas Karlberg, Marita Lipsanen-Nyman, Hannu Jalanko
BACKGROUND: Mulibrey nanism (MUL) is a rare inherited disease caused by genetic defects affecting peroxisomal TRIM37 protein. MUL affects multiple organs, leading to growth retardation and early onset type 2 diabetes. We aimed to characterize the structure and function of kidneys and the urinary tract in a large cohort of Finnish MUL patients. METHODS: Ultrasound, magnetic resonance imaging (MRI), and autopsy findings of the kidneys and urinary tract from 101 MUL patients were retrospectively analyzed...
April 22, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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