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Christoph Ahlgrim, Oliver Maenner, Manfred W Baumstark
BACKGROUND: Speech recognition software might increase productivity in clinical documentation. However, low user satisfaction with speech recognition software has been observed. In this case study, an approach for implementing a speech recognition software package at a university-based outpatient department is presented. METHODS: Methods to create a specific dictionary for the context "sports medicine" and a shared vocabulary learning function are demonstrated. The approach is evaluated for user satisfaction (using a questionnaire before and 10 weeks after software implementation) and its impact on the time until the final medical document was saved into the system...
October 18, 2016: BMC Medical Informatics and Decision Making
Q Magis, D Jullien, C Gaudy-Marqueste, K Baumstark, M Viguier, H Bachelez, F Guibal, E Delaporte, E Karimova, H Montaudié, T Boye, F Aubin, M Beylot-Barry, M-A Richard
BACKGROUND: Limited information is available regarding factors associated with long-term drug survival of infliximab for psoriasis in real life. OBJECTIVES: The main aim pf this study was to identify predictors of long-term (>12 months) drug survival among patients treated with infliximab for psoriasis in a real-world clinical setting. METHODS: Retrospectively collected data, relating to disease, patient characteristics and treatment procedures, in a multicentre observational cohort of patients with moderate-to-severe plaque psoriasis treated with infliximab at eight university hospitals, 120 of whom maintained a response to infliximab for more than 12 months, were compared with prospectively collected data in the same centres from 54 patients who experienced secondary loss of response within a 12-month period...
June 21, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Christine E Hellweg, Luis F Spitta, Bernd Henschenmacher, Sebastian Diegeler, Christa Baumstark-Khan
Charged particles, such as carbon ions, bear the promise of a more effective cancer therapy. In human spaceflight, exposure to charged particles represents an important risk factor for chronic and late effects such as cancer. Biological effects elicited by charged particle exposure depend on their characteristics, e.g., on linear energy transfer (LET). For diverse outcomes (cell death, mutation, transformation, and cell-cycle arrest), an LET dependency of the effect size was observed. These outcomes result from activation of a complex network of signaling pathways in the DNA damage response, which result in cell-protective (DNA repair and cell-cycle arrest) or cell-destructive (cell death) reactions...
2016: Frontiers in Oncology
Vaibhav Shinde, Sonja Brungs, Margit Henry, Lucia Wegener, Harshal Nemade, Tamara Rotshteyn, Aviseka Acharya, Christa Baumstark-Khan, Christine E Hellweg, Jürgen Hescheler, Ruth Hemmersbach, Agapios Sachinidis
BACKGROUND/AIMS: Embryonic developmental studies under microgravity conditions in space are very limited. To study the effects of altered gravity on the embryonic development processes we established an in vitro methodology allowing differentiation of mouse embryonic stem cells (mESCs) under simulated microgravity within a fast-rotating clinostat (clinorotation) and capture of microarray-based gene signatures. METHODS: The differentiating mESCs were cultured in a 2D pipette clinostat...
2016: Cellular Physiology and Biochemistry
Vladimir Y Lunin, Natalia L Lunina, Tatiana E Petrova, Manfred W Baumstark, Alexandre G Urzhumtsev
A Monte Carlo-type approach for low- and medium-resolution phasing of single-particle diffraction data is suggested. Firstly, the single-particle phase problem is substituted with the phase problem for an imaginary crystal. A unit cell of this crystal contains a single isolated particle surrounded by a large volume of bulk solvent. The developed phasing procedure then generates a large number of connected and finite molecular masks, calculates their Fourier coefficients, selects the sets with magnitudes that are highly correlated with the experimental values and finally aligns the selected phase sets and calculates the averaged phase values...
January 2016: Acta Crystallographica. Section D, Structural Biology
Stefan Pleus, Annette Baumstark, Delia Rittmeyer, Nina Jendrike, Cornelia Haug, Guido Freckmann
Objective For patients with diabetes, regular self-monitoring of blood glucose (SMBG) is essential to ensure adequate glycemic control. Therefore, accurate and reliable blood glucose measurements with SMBG systems are necessary. The international standard ISO 15197 describes requirements for SMBG systems, such as limits within which 95% of glucose results have to fall to reach acceptable system accuracy. The 2013 version of this standard sets higher demands, especially regarding system accuracy, than the currently still valid edition...
May 2016: Current Medical Research and Opinion
Christine E Hellweg, Shahana Dilruba, Astrid Adrian, Sebastian Feles, Claudia Schmitz, Thomas Berger, Bartos Przybyla, Luca Briganti, Markus Franz, Jürgen Segerer, Luis F Spitta, Bernd Henschenmacher, Bikash Konda, Sebastian Diegeler, Christa Baumstark-Khan, Corinna Panitz, Günther Reitz
One factor contributing to the high uncertainty in radiation risk assessment for long-term space missions is the insufficient knowledge about possible interactions of radiation with other spaceflight environmental factors. Such factors, e.g. microgravity, have to be considered as possibly additive or even synergistic factors in cancerogenesis. Regarding the effects of microgravity on signal transduction, it cannot be excluded that microgravity alters the cellular response to cosmic radiation, which comprises a complex network of signaling pathways...
November 2015: Life Sciences in Space Research
Denise Zdzieblik, Steffen Oesser, Manfred W Baumstark, Albert Gollhofer, Daniel König
Protein supplementation in combination with resistance training may increase muscle mass and muscle strength in elderly subjects. The objective of this study was to assess the influence of post-exercise protein supplementation with collagen peptides v. placebo on muscle mass and muscle function following resistance training in elderly subjects with sarcopenia. A total of fifty-three male subjects (72·2 (sd 4·68) years) with sarcopenia (class I or II) completed this randomised double-blind placebo-controlled study...
October 28, 2015: British Journal of Nutrition
Arif A Chishti, Christine E Hellweg, Thomas Berger, Christa Baumstark-Khan, Sebastian Feles, Thorben Kätzel, Günther Reitz
The radiation risk assessment for long-term space missions requires knowledge on the biological effectiveness of different space radiation components, e.g. heavy ions, on the interaction of radiation and other space environmental factors such as microgravity, and on the physical and biological dose distribution in the human body. Space experiments and ground-based experiments at heavy ion accelerators require fast and reliable test systems with an easy readout for different endpoints. In order to determine the effect of different radiation qualities on cellular proliferation and the biological depth dose distribution after heavy ion exposure, a stable human cell line expressing a novel fluorescent protein was established and characterized...
January 2015: Life Sciences in Space Research
Guido Freckmann, Manuela Link, Christina Schmid, Stefan Pleus, Annette Baumstark, Cornelia Haug
BACKGROUND: Adherence to established standards (e.g., International Organization for Standardization [ISO] 15197) is important to ensure comparable and sufficient accuracy of systems for self-monitoring of blood glucose (SMBG). Accuracy evaluation was performed for different SMBG systems available in Europe with three reagent lots each. MATERIALS AND METHODS: Test procedures followed the recently published revision ISO 15197:2013. Comparison measurements were performed with a glucose oxidase (YSI 2300 STAT Plus™ glucose analyzer; YSI Inc...
September 2015: Diabetes Technology & Therapeutics
Guido Freckmann, Stefan Pleus, Manuela Link, Annette Baumstark, Christina Schmid, Josef Högel, Cornelia Haug
INTRODUCTION: Systems for self-monitoring of blood glucose (SMBG) are expected to be accurate enough to provide reliable measurement results. Especially in the low glycemic range, adequate therapeutic decisions based on reliable results can alleviate complications associated with hypoglycemia. MATERIALS AND METHODS: The accuracy of four SMBG systems (system 1 was the ACCU-CHEK(®) Aviva [Roche Diagnostics GmbH, Mannheim, Germany], system 2 was the Contour(®) XT [Bayer Consumer Care AG, Basel, Switzerland], system 3 was the GlucoCheck XL [aktivmed GmbH, Augsberg, Germany], and system 4 was the GlucoMen(®) LX PLUS [A...
September 2015: Diabetes Technology & Therapeutics
Thomas Lange, Martin Buechert, Manfred W Baumstark, Peter Deibert, Sarah Gerner, Henric Rydén, Jochen Seufert, Ulrike Korsten-Reck
PURPOSE: To evaluate a protocol combining abdominal fat-water magnetic resonance imaging (MRI) and liver single voxel magnetic resonance spectroscopy (MRS) for studies of childhood obesity. MATERIALS AND METHODS: Six obese male children and five age-matched normal-weight controls underwent abdominal fat-water Dixon MRI based on a gradient echo sequence with multiple echo times and single voxel liver MRS at a field strength of 3T. The MRI/MRS data were compared with data previously acquired from an obese adult cohort and with anthropometric and blood parameters that are typically acquired for screening in childhood obesity...
November 2015: Journal of Magnetic Resonance Imaging: JMRI
Manuela Link, Christina Schmid, Stefan Pleus, Annette Baumstark, Delia Rittmeyer, Cornelia Haug, Guido Freckmann
BACKGROUND: The standard ISO (International Organization for Standardization) 15197 is widely accepted for the accuracy evaluation of systems for self-monitoring of blood glucose (SMBG). Accuracy evaluation was performed for 4 SMBG systems (Accu-Chek Aviva, ContourXT, GlucoCheck XL, GlucoMen LX PLUS) with 3 test strip lots each. To investigate a possible impact of the comparison method on system accuracy data, 2 different established methods were used. METHODS: The evaluation was performed in a standardized manner following test procedures described in ISO 15197:2003 (section 7...
September 2015: Journal of Diabetes Science and Technology
Guido Freckmann, Christina Schmid, Annette Baumstark, Malte Rutschmann, Cornelia Haug, Lutz Heinemann
In the European Union (EU), the ISO (International Organization for Standardization) 15197 standard is applicable for the evaluation of systems for self-monitoring of blood glucose (SMBG) before the market approval. In 2013, a revised version of this standard was published. Relevant revisions in the analytical performance requirements are the inclusion of the evaluation of influence quantities, for example, hematocrit, and some changes in the testing procedures for measurement precision and system accuracy evaluation, for example, number of test strip lots...
July 2015: Journal of Diabetes Science and Technology
M E Baumstark, J Nussberger, F S Boretti, M W Baumstark, B Riond, C E Reusch, N S Sieber-Ruckstuhl
BACKGROUND: Measurement of plasma renin activity (PRA) is the gold standard for monitoring mineralocorticoid treatment in humans with primary hypoadrenocorticism (PH). OBJECTIVES: To compare PRA in dogs with newly diagnosed PH, dogs with diseases mimicking PH, and healthy dogs, and evaluate measurement of PRA to monitor therapeutic effects in dogs with PH treated with different mineralocorticoids. ANIMALS: Eleven dogs with newly diagnosed PH (group 1), 10 dogs with diseases mimicking PH (group 2), 21 healthy dogs (group 3), 17 dogs with treated PH (group 4)...
September 2014: Journal of Veterinary Internal Medicine
Arif Ali Chishti, Christa Baumstark-Khan, Christine E Hellweg, Günther Reitz
Ionizing radiation modulates several signaling pathways resulting in transcription factor activation. Nuclear factor kappa B (NF-κB) is one of the most important transcription factors that respond to changes in the environment of a mammalian cell. NF-κB plays a key role not only in inflammation and immune regulation but also in cellular radiation response. In response to DNA damage, NF-κB might inhibit apoptosis and promote carcinogenesis. Our previous studies showed that ionizing radiation is very effective in inducing biological damages...
August 2014: Radiation and Environmental Biophysics
Guido Freckmann, Christina Schmid, Stefan Pleus, Annette Baumstark, Manuela Link, Erhard Stolberg, Cornelia Haug, Jochen Sieber
BACKGROUND: Point-of-care testing (POCT) of blood glucose (BG) is performed by medical personnel in clinical settings as well as by patients themselves for self-monitoring of blood glucose (SMBG) at home. We investigated if a system mainly intended for SMBG by people with diabetes, but also suitable for BG measurements by medical personnel, can achieve measurement accuracy on capillary blood samples comparable with professional-use POCT systems. METHODS: System accuracy was evaluated under standardised conditions, following the ISO standard 15197:2003...
July 2014: Clinical Chemistry and Laboratory Medicine: CCLM
M E Baumstark, N S Sieber-Ruckstuhl, C Müller, M Wenger, F S Boretti, C E Reusch
BACKGROUND: Some dogs with primary hypoadrenocorticism (HA) have normal sodium and potassium concentrations, a phenomenon called atypical Addison's disease. The assumption that the zona glomerulosa and aldosterone secretion in these dogs are normal seems widely accepted; however, aldosterone measurements are missing in most published cases. OBJECTIVES: To measure aldosterone in dogs with HA with and without electrolyte abnormalities and to determine the time point of aldosterone peak concentrations during ACTH stimulation...
January 2014: Journal of Veterinary Internal Medicine
Guido Freckmann, Christina Schmid, Annette Baumstark, Stefan Pleus, Manuela Link, Cornelia Haug
No abstract text is available yet for this article.
November 2013: Journal of Diabetes Science and Technology
Guido Freckmann, Christina Schmid, Annette Baumstark, Stefan Pleus, Manuela Link, Cornelia Haug
No abstract text is available yet for this article.
November 2013: Journal of Diabetes Science and Technology
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