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Nina Jendrike, Annette Baumstark, Stefan Pleus, Christina Liebing, Alexandra Beer, Frank Flacke, Cornelia Haug, Guido Freckmann
BACKGROUND: Self-monitoring of blood glucose (SMBG) is important in diabetes therapy; however, not all SMBG systems are sufficiently accurate. In addition, some SMBG systems are influenced by the user's hematocrit value. METHODS: System accuracy and hematocrit influence was evaluated for four SMBG systems with built-in insulin dose advisors (Accu-Chek® Aviva Expert [1], FreeStyle InsuLinx [2], FreeStyle Precision Neo [3], MyStar DoseCoach® [4]) based on International Organization for Standardization (ISO) 15197:2013 section 6...
April 2018: Diabetes Technology & Therapeutics
Elmar Kriegler, Gunnar Luderer, Nico Bauer, Lavinia Baumstark, Shinichiro Fujimori, Alexander Popp, Joeri Rogelj, Jessica Strefler, Detlef P van Vuuren
We explore the feasibility of limiting global warming to 1.5°C without overshoot and without the deployment of carbon dioxide removal (CDR) technologies. For this purpose, we perform a sensitivity analysis of four generic emissions reduction measures to identify a lower bound on future CO2 emissions from fossil fuel combustion and industrial processes. Final energy demand reductions and electrification of energy end uses as well as decarbonization of electricity and non-electric energy supply are all considered...
May 13, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Guido Freckmann, Nina Jendrike, Annette Baumstark, Stefan Pleus, Christina Liebing, Cornelia Haug
INTRODUCTION: The international standard ISO 15197:2013 requires a user performance evaluation to assess if intended users are able to obtain accurate blood glucose measurement results with a self-monitoring of blood glucose (SMBG) system. In this study, user performance was evaluated for four SMBG systems on the basis of ISO 15197:2013, and possibly related insulin dosing errors were calculated. Additionally, accuracy was assessed in the hands of study personnel. METHODS: Accu-Chek® Performa Connect (A), Contour® plus ONE (B), FreeStyle Optium Neo (C), and OneTouch Select® Plus (D) were evaluated with one test strip lot...
March 3, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Arif Ali Chishti, Christa Baumstark-Khan, Kristina Koch, Waldemar Kolanus, Sebastian Feles, Bikash Konda, Abid Azhar, Luis F Spitta, Bernd Henschenmacher, Sebastian Diegeler, Claudia Schmitz, Christine E Hellweg
Nuclear factor kappaB (NF-κB) is a central transcription factor in the immune system and modulates cell survival in response to radiotherapy. Activation of NF-κB was shown to be an early step in the cellular response to ultraviolet A (UVA) and ionizing radiation exposure in human cells. NF-κB activation by the genotoxic stress-dependent sub-pathway after exposure to different radiation qualities had been evaluated to a very limited extent. In addition, the resulting gene expression profile, which shapes the cellular and tissue response, is unknown...
January 25, 2018: Radiation Research
Daniela Baumstark, Sindy Neumann, Johannes Eiglsperger, Sabine Norkauer, Jakob Wieczorek, Markus Fuhrmann, Michael Mündner, Julia Wack, Hubert Scharnagl, Tatjana Stojakovic, Winfried März, Philipp Pagel
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Andy Schmitt, Patrice Crochet, Karine Baumstark, Claire Tourette, Sabine Poizac, Audrey Pivano, Léon Boubli, Ludovic Cravello, Aubert Agostini
BACKGROUND: Laparoscopic surgery has become the preferred surgical approach due to a reduction in postoperative pain, better recovery, shorter hospitalization, and improved esthetic outcomes. Laparoscopic surgery with single-port laparoscopy (SPL) is a laparoscopic surgery technique that is based on making a single parietal incision using a single trocar specifically designed to allow introduction of several instruments. The level of evidence regarding the advantages of SPL in terms of postoperative pain has remained low despite several randomized studies...
January 15, 2018: Trials
Tobias Pflüger, Camila F Hernández, Philipp Lewe, Fabian Frank, Haydyn Mertens, Dmitri Svergun, Manfred W Baumstark, Vladimir Y Lunin, Mike S M Jetten, Susana L A Andrade
Sensing and uptake of external ammonium is essential for anaerobic ammonium-oxidizing (anammox) bacteria, and is typically the domain of the ubiquitous Amt/Rh ammonium transporters. Here, we report on the structure and function of an ammonium sensor/transducer from the anammox bacterium "Candidatus Kuenenia stuttgartiensis" that combines a membrane-integral ammonium transporter domain with a fused histidine kinase. It contains a high-affinity ammonium binding site not present in assimilatory Amt proteins...
January 11, 2018: Nature Communications
Dillon Friday, Priyadarshini Mukkara, Robert A Owens, Tilman Baumstark, Michael F Bruist
Potato spindle tuber viroid (PSTVd) is a circular, single-stranded, noncoding RNA plant pathogen that is a useful model for studying the processing of noncoding RNA in eukaryotes. Infective PSTVd circles are replicated via an asymmetric rolling circle mechanism to form linear multimeric RNAs. An endonuclease cleaves these into monomers, and a ligase seals these into mature circles. All eukaryotes may have such enzymes for processing noncoding RNA. As a test, we investigated the processing of three PSTVd RNA constructs in the yeast Saccharomyces cerevisiae Of these, only one form, a construct that adopts a previously described tetraloop-containing conformation (TL), produces circles...
December 15, 2017: Journal of Virology
Annette Baumstark, Nina Jendrike, Stefan Pleus, Christina Liebing, Cornelia Haug, Guido Freckmann
No abstract text is available yet for this article.
September 1, 2017: Journal of Diabetes Science and Technology
Annette Baumstark, Nina Jendrike, Stefan Pleus, Cornelia Haug, Guido Freckmann
OBJECTIVE: Self-monitoring of blood glucose (BG) is an essential part of diabetes therapy. Accurate and reliable results from BG monitoring systems (BGMS) are important especially when they are used to calculate insulin doses. This study aimed at assessing system accuracy of BGMS and possibly related insulin dosing errors. RESEARCH DESIGN AND METHODS: System accuracy of six different BGMS (Accu-Chek ® Aviva Nano, Accu-Chek Mobile, Accu-Chek Performa Nano, CONTOUR ® NEXT LINK 2...
October 2017: Diabetes Technology & Therapeutics
Ulrike Kamecke, Annette Baumstark, Nina Jendrike, Cornelia Haug, Guido Freckmann
No abstract text is available yet for this article.
July 2017: Journal of Diabetes Science and Technology
Guido Freckmann, Annette Baumstark, Stefan Pleus
Recently, the Food and Drug Administration (FDA) published guidance documents for point-of-care testing (POCT) and over-the-counter (OTC) blood glucose monitoring systems (BGMS). These are expected to improve weaknesses of the already established ISO 15197:2013 standard accuracy evaluation for OTC BGMS; however, the proposed criteria and procedures rather raise new questions. As an example, the OTC guidance stipulates tighter accuracy criteria in the low glycemic range than the POCT guidance for no obvious reason...
November 2017: Journal of Diabetes Science and Technology
Nina Jendrike, Annette Baumstark, Chieh-Hsiao Chen, Delia Rittmeyer, Cornelia Haug, Guido Freckmann
The novel system for self-monitoring of blood glucose (SMBG) PixoTest couples SMBG to a smartphone and does not require a separate glucose meter. The integrated system includes all components necessary for a glucose measurement, and owing to a colorimetric measurement principle, a smartphone camera can capture color changes and a software app calculates the corresponding glucose value. In the presented study, the system was evaluated in terms of system accuracy as described in ISO 15197:2013. It was shown to fulfill system accuracy requirements with 97-99% of results from three different reagent system lots within the accuracy limits and 100% of results within zone A of the consensus error grid...
November 2017: Journal of Diabetes Science and Technology
Denise Schaffner, Dominik von Elverfeldt, Peter Deibert, Adhara Lazaro, Irmgard Merfort, Lisa Lutz, Jakob Neubauer, Manfred W Baumstark, Wolfgang Kreisel, Wilfried Reichardt
PURPOSE: To test a magnetic resonance (MR) scanning protocol as a noninvasive tool to determine hepatic hemodynamics and to assess the degree of liver fibrosis in an animal model of liver fibrosis and cirrhosis. MATERIALS AND METHODS: Fifty-four male Wistar rats were studied. Thirty-nine received thioacetamide (TAA) in their drinking water for either 12 or 16 weeks. MR measurements were performed using flow-sensitive 2D phase-contrast MRI and a 9.4T preclinical scanner...
November 2017: Journal of Magnetic Resonance Imaging: JMRI
Guido Freckmann, Annette Baumstark, Nina Jendrike, Delia Rittmeyer, Stefan Pleus, Cornelia Haug
BACKGROUND: Self-monitoring of blood glucose (BG) is an integral part in the therapy of people with diabetes, which is why blood glucose monitoring systems (BGMS) have to fulfill minimum accuracy requirements. However, accuracy is often assessed by trained operators, although such assessments do not necessarily allow for drawing conclusions on accuracy in the hands of lay users. METHODS: The accuracy of 4 different BGMS (Accu-Chek® Active, Accu-Chek® Performa, Contour® Plus, and OneTouch® SelectSimple™) in the hands of lay users and trained study personnel was assessed in this study...
April 2017: Diabetes Technology & Therapeutics
Luis F Spitta, Sebastian Diegeler, Christa Baumstark-Khan, Christine E Hellweg
Epidemiological studies show that there is a link between urban water pollution and increase in human morbidity and mortality. With the increase in number of new substances arising from the chemical, pharmaceutical, and agricultural industries, there is an urgent need to develop biological test systems for fast evaluation of potential risks to humans and the environmental ecosystems. Here, a combined cellular reporter assay based on the cellular survival and the stress-induced activation of the survival-promoting factor nuclear factor κB (NF-κB) and its use for the detection of cytotoxicity and cancer-related stress responses is presented...
November 22, 2016: Environmental Science and Pollution Research International
Christoph Ahlgrim, Oliver Maenner, Manfred W Baumstark
BACKGROUND: Speech recognition software might increase productivity in clinical documentation. However, low user satisfaction with speech recognition software has been observed. In this case study, an approach for implementing a speech recognition software package at a university-based outpatient department is presented. METHODS: Methods to create a specific dictionary for the context "sports medicine" and a shared vocabulary learning function are demonstrated...
October 18, 2016: BMC Medical Informatics and Decision Making
Q Magis, D Jullien, C Gaudy-Marqueste, K Baumstark, M Viguier, H Bachelez, F Guibal, E Delaporte, E Karimova, H Montaudié, T Boye, F Aubin, M Beylot-Barry, M-A Richard
BACKGROUND: Limited information is available regarding factors associated with long-term drug survival of infliximab for psoriasis in real life. OBJECTIVES: The main aim pf this study was to identify predictors of long-term (>12 months) drug survival among patients treated with infliximab for psoriasis in a real-world clinical setting. METHODS: Retrospectively collected data, relating to disease, patient characteristics and treatment procedures, in a multicentre observational cohort of patients with moderate-to-severe plaque psoriasis treated with infliximab at eight university hospitals, 120 of whom maintained a response to infliximab for more than 12 months, were compared with prospectively collected data in the same centres from 54 patients who experienced secondary loss of response within a 12-month period...
January 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
Christine E Hellweg, Luis F Spitta, Bernd Henschenmacher, Sebastian Diegeler, Christa Baumstark-Khan
Charged particles, such as carbon ions, bear the promise of a more effective cancer therapy. In human spaceflight, exposure to charged particles represents an important risk factor for chronic and late effects such as cancer. Biological effects elicited by charged particle exposure depend on their characteristics, e.g., on linear energy transfer (LET). For diverse outcomes (cell death, mutation, transformation, and cell-cycle arrest), an LET dependency of the effect size was observed. These outcomes result from activation of a complex network of signaling pathways in the DNA damage response, which result in cell-protective (DNA repair and cell-cycle arrest) or cell-destructive (cell death) reactions...
2016: Frontiers in Oncology
Vaibhav Shinde, Sonja Brungs, Margit Henry, Lucia Wegener, Harshal Nemade, Tamara Rotshteyn, Aviseka Acharya, Christa Baumstark-Khan, Christine E Hellweg, Jürgen Hescheler, Ruth Hemmersbach, Agapios Sachinidis
BACKGROUND/AIMS: Embryonic developmental studies under microgravity conditions in space are very limited. To study the effects of altered gravity on the embryonic development processes we established an in vitro methodology allowing differentiation of mouse embryonic stem cells (mESCs) under simulated microgravity within a fast-rotating clinostat (clinorotation) and capture of microarray-based gene signatures. METHODS: The differentiating mESCs were cultured in a 2D pipette clinostat...
2016: Cellular Physiology and Biochemistry
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