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https://www.readbyqxmd.com/read/29369006/linear-energy-transfer-modulates-radiation-induced-nf-kappa-b-activation-and-expression-of-its-downstream-target-genes
#1
Arif Ali Chishti, Christa Baumstark-Khan, Kristina Koch, Waldemar Kolanus, Sebastian Feles, Bikash Konda, Abid Azhar, Luis F Spitta, Bernd Henschenmacher, Sebastian Diegeler, Claudia Schmitz, Christine E Hellweg
Nuclear factor kappaB (NF-κB) is a central transcription factor in the immune system and modulates cell survival in response to radiotherapy. Activation of NF-κB was shown to be an early step in the cellular response to ultraviolet A (UVA) and ionizing radiation exposure in human cells. NF-κB activation by the genotoxic stress-dependent sub-pathway after exposure to different radiation qualities had been evaluated to a very limited extent. In addition, the resulting gene expression profile, which shapes the cellular and tissue response, is unknown...
January 25, 2018: Radiation Research
https://www.readbyqxmd.com/read/29365781/lipoprotein-profiling-with-the-axinon%C3%A2-system
#2
Daniela Baumstark, Sindy Neumann, Johannes Eiglsperger, Sabine Norkauer, Jakob Wieczorek, Markus Fuhrmann, Michael Mündner, Julia Wack, Hubert Scharnagl, Tatjana Stojakovic, Winfried März, Philipp Pagel
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29335017/effect-of-laparoscopy-by-single-port-endoscopic-access-in-benign-adnexal-surgery-study-protocol-for-a-randomized-controlled-trial
#3
Andy Schmitt, Patrice Crochet, Karine Baumstark, Claire Tourette, Sabine Poizac, Audrey Pivano, Léon Boubli, Ludovic Cravello, Aubert Agostini
BACKGROUND: Laparoscopic surgery has become the preferred surgical approach due to a reduction in postoperative pain, better recovery, shorter hospitalization, and improved esthetic outcomes. Laparoscopic surgery with single-port laparoscopy (SPL) is a laparoscopic surgery technique that is based on making a single parietal incision using a single trocar specifically designed to allow introduction of several instruments. The level of evidence regarding the advantages of SPL in terms of postoperative pain has remained low despite several randomized studies...
January 15, 2018: Trials
https://www.readbyqxmd.com/read/29323112/signaling-ammonium-across-membranes-through-an-ammonium-sensor-histidine-kinase
#4
Tobias Pflüger, Camila F Hernández, Philipp Lewe, Fabian Frank, Haydyn Mertens, Dmitri Svergun, Manfred W Baumstark, Vladimir Y Lunin, Mike S M Jetten, Susana L A Andrade
Sensing and uptake of external ammonium is essential for anaerobic ammonium-oxidizing (anammox) bacteria, and is typically the domain of the ubiquitous Amt/Rh ammonium transporters. Here, we report on the structure and function of an ammonium sensor/transducer from the anammox bacterium "Candidatus Kuenenia stuttgartiensis" that combines a membrane-integral ammonium transporter domain with a fused histidine kinase. It contains a high-affinity ammonium binding site not present in assimilatory Amt proteins. The levels of phosphorylated histidine in the kinase are coupled to the presence of ammonium, as conformational changes during signal recognition by the Amt module are transduced internally to modulate the kinase activity...
January 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/28978701/processing-of-potato-spindle-tuber-viroid-pstvd-rnas-in-yeast-a-nonconventional-host
#5
Dillon Friday, Priyadarshini Mukkara, Robert A Owens, Tilman Baumstark, Michael F Bruist
Potato spindle tuber viroid (PSTVd) is a circular, single-stranded, noncoding RNA plant pathogen that is a useful model for the processing of noncoding RNA in eukaryotes. Infective PSTVd circles are replicated via an asymmetric rolling circle mechanism to form linear multimeric RNAs. An endonuclease cleaves these into monomers; a ligase seals these into mature circles. All eukaryotes may have such enzymes for processing noncoding RNA. As a test, we investigated the processing of three PSTVd RNA constructs in the yeast Saccharomyces cerevisiae...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28931322/accuracy-evaluation-of-a-new-system-for-self-monitoring-of-blood-glucose-with-three-test-strip-lots-based-on-iso-15197-2013
#6
Annette Baumstark, Nina Jendrike, Stefan Pleus, Christina Liebing, Cornelia Haug, Guido Freckmann
No abstract text is available yet for this article.
September 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28704063/evaluation-of-accuracy-of-six-blood-glucose-monitoring-systems-and-modeling-of-possibly-related-insulin-dosing-errors
#7
Annette Baumstark, Nina Jendrike, Stefan Pleus, Cornelia Haug, Guido Freckmann
OBJECTIVE: Self-monitoring of blood glucose (BG) is an essential part of diabetes therapy. Accurate and reliable results from BG monitoring systems (BGMS) are important especially when they are used to calculate insulin doses. This study aimed at assessing system accuracy of BGMS and possibly related insulin dosing errors. RESEARCH DESIGN AND METHODS: System accuracy of six different BGMS (Accu-Chek ® Aviva Nano, Accu-Chek Mobile, Accu-Chek Performa Nano, CONTOUR ® NEXT LINK 2...
October 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28627219/accuracy-assessment-of-an-improved-version-of-an-established-blood-glucose-monitoring-system-for-self-testing-following-iso-15197-2013
#8
Ulrike Kamecke, Annette Baumstark, Nina Jendrike, Cornelia Haug, Guido Freckmann
No abstract text is available yet for this article.
July 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28587476/do-the-new-fda-guidance-documents-help-improving-performance-of-blood-glucose-monitoring-systems-compared-with-iso-15197
#9
Guido Freckmann, Annette Baumstark, Stefan Pleus
Recently, the Food and Drug Administration (FDA) published guidance documents for point-of-care testing (POCT) and over-the-counter (OTC) blood glucose monitoring systems (BGMS). These are expected to improve weaknesses of the already established ISO 15197:2013 standard accuracy evaluation for OTC BGMS; however, the proposed criteria and procedures rather raise new questions. As an example, the OTC guidance stipulates tighter accuracy criteria in the low glycemic range than the POCT guidance for no obvious reason...
November 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28459160/introduction-of-a-novel-smartphone-coupled-blood-glucose-monitoring-system
#10
Nina Jendrike, Annette Baumstark, Chieh-Hsiao Chen, Delia Rittmeyer, Cornelia Haug, Guido Freckmann
The novel system for self-monitoring of blood glucose (SMBG) PixoTest couples SMBG to a smartphone and does not require a separate glucose meter. The integrated system includes all components necessary for a glucose measurement, and owing to a colorimetric measurement principle, a smartphone camera can capture color changes and a software app calculates the corresponding glucose value. In the presented study, the system was evaluated in terms of system accuracy as described in ISO 15197:2013. It was shown to fulfill system accuracy requirements with 97-99% of results from three different reagent system lots within the accuracy limits and 100% of results within zone A of the consensus error grid...
November 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28240794/phase-contrast-mr-flow-imaging-a-tool-to-determine-hepatic-hemodynamics-in-rats-with-a-healthy-fibrotic-or-cirrhotic-liver
#11
Denise Schaffner, Dominik von Elverfeldt, Peter Deibert, Adhara Lazaro, Irmgard Merfort, Lisa Lutz, Jakob Neubauer, Manfred W Baumstark, Wolfgang Kreisel, Wilfried Reichardt
PURPOSE: To test a magnetic resonance (MR) scanning protocol as a noninvasive tool to determine hepatic hemodynamics and to assess the degree of liver fibrosis in an animal model of liver fibrosis and cirrhosis. MATERIALS AND METHODS: Fifty-four male Wistar rats were studied. Thirty-nine received thioacetamide (TAA) in their drinking water for either 12 or 16 weeks. MR measurements were performed using flow-sensitive 2D phase-contrast MRI and a 9.4T preclinical scanner...
November 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225633/accuracy-evaluation-of-four-blood-glucose-monitoring-systems-in-the-hands-of-intended-users-and-trained-personnel-based-on-iso-15197-requirements
#12
Guido Freckmann, Annette Baumstark, Nina Jendrike, Delia Rittmeyer, Stefan Pleus, Cornelia Haug
BACKGROUND: Self-monitoring of blood glucose (BG) is an integral part in the therapy of people with diabetes, which is why blood glucose monitoring systems (BGMS) have to fulfill minimum accuracy requirements. However, accuracy is often assessed by trained operators, although such assessments do not necessarily allow for drawing conclusions on accuracy in the hands of lay users. METHODS: The accuracy of 4 different BGMS (Accu-Chek(®) Active, Accu-Chek(®) Performa, Contour(®)Plus, and OneTouch(®) SelectSimple™) in the hands of lay users and trained study personnel was assessed in this study...
April 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27878482/an-in-vitro-approach-for-water-quality-determination-activation-of-nf-%C3%AE%C2%BAb-as-marker-for-cancer-related-stress-responses-induced-by-anthropogenic-pollutants-of-drinking-water
#13
Luis F Spitta, Sebastian Diegeler, Christa Baumstark-Khan, Christine E Hellweg
Epidemiological studies show that there is a link between urban water pollution and increase in human morbidity and mortality. With the increase in number of new substances arising from the chemical, pharmaceutical, and agricultural industries, there is an urgent need to develop biological test systems for fast evaluation of potential risks to humans and the environmental ecosystems. Here, a combined cellular reporter assay based on the cellular survival and the stress-induced activation of the survival-promoting factor nuclear factor κB (NF-κB) and its use for the detection of cytotoxicity and cancer-related stress responses is presented...
November 22, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27756284/introduction-of-digital-speech-recognition-in-a-specialised-outpatient-department-a-case-study
#14
Christoph Ahlgrim, Oliver Maenner, Manfred W Baumstark
BACKGROUND: Speech recognition software might increase productivity in clinical documentation. However, low user satisfaction with speech recognition software has been observed. In this case study, an approach for implementing a speech recognition software package at a university-based outpatient department is presented. METHODS: Methods to create a specific dictionary for the context "sports medicine" and a shared vocabulary learning function are demonstrated. The approach is evaluated for user satisfaction (using a questionnaire before and 10 weeks after software implementation) and its impact on the time until the final medical document was saved into the system...
October 18, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27325600/predictors-of-long-term-drug-survival-for-infliximab-in-psoriasis
#15
MULTICENTER STUDY
Q Magis, D Jullien, C Gaudy-Marqueste, K Baumstark, M Viguier, H Bachelez, F Guibal, E Delaporte, E Karimova, H Montaudié, T Boye, F Aubin, M Beylot-Barry, M-A Richard
BACKGROUND: Limited information is available regarding factors associated with long-term drug survival of infliximab for psoriasis in real life. OBJECTIVES: The main aim pf this study was to identify predictors of long-term (>12 months) drug survival among patients treated with infliximab for psoriasis in a real-world clinical setting. METHODS: Retrospectively collected data, relating to disease, patient characteristics and treatment procedures, in a multicentre observational cohort of patients with moderate-to-severe plaque psoriasis treated with infliximab at eight university hospitals, 120 of whom maintained a response to infliximab for more than 12 months, were compared with prospectively collected data in the same centres from 54 patients who experienced secondary loss of response within a 12-month period...
January 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27047795/transcription-factors-in-the-cellular-response-to-charged-particle-exposure
#16
REVIEW
Christine E Hellweg, Luis F Spitta, Bernd Henschenmacher, Sebastian Diegeler, Christa Baumstark-Khan
Charged particles, such as carbon ions, bear the promise of a more effective cancer therapy. In human spaceflight, exposure to charged particles represents an important risk factor for chronic and late effects such as cancer. Biological effects elicited by charged particle exposure depend on their characteristics, e.g., on linear energy transfer (LET). For diverse outcomes (cell death, mutation, transformation, and cell-cycle arrest), an LET dependency of the effect size was observed. These outcomes result from activation of a complex network of signaling pathways in the DNA damage response, which result in cell-protective (DNA repair and cell-cycle arrest) or cell-destructive (cell death) reactions...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27035921/simulated-microgravity-modulates-differentiation-processes-of-embryonic-stem-cells
#17
Vaibhav Shinde, Sonja Brungs, Margit Henry, Lucia Wegener, Harshal Nemade, Tamara Rotshteyn, Aviseka Acharya, Christa Baumstark-Khan, Christine E Hellweg, Jürgen Hescheler, Ruth Hemmersbach, Agapios Sachinidis
BACKGROUND/AIMS: Embryonic developmental studies under microgravity conditions in space are very limited. To study the effects of altered gravity on the embryonic development processes we established an in vitro methodology allowing differentiation of mouse embryonic stem cells (mESCs) under simulated microgravity within a fast-rotating clinostat (clinorotation) and capture of microarray-based gene signatures. METHODS: The differentiating mESCs were cultured in a 2D pipette clinostat...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26894542/mask-based-approach-to-phasing-of-single-particle-diffraction-data
#18
Vladimir Y Lunin, Natalia L Lunina, Tatiana E Petrova, Manfred W Baumstark, Alexandre G Urzhumtsev
A Monte Carlo-type approach for low- and medium-resolution phasing of single-particle diffraction data is suggested. Firstly, the single-particle phase problem is substituted with the phase problem for an imaginary crystal. A unit cell of this crystal contains a single isolated particle surrounded by a large volume of bulk solvent. The developed phasing procedure then generates a large number of connected and finite molecular masks, calculates their Fourier coefficients, selects the sets with magnitudes that are highly correlated with the experimental values and finally aligns the selected phase sets and calculates the averaged phase values...
January 2016: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/26809001/performance-of-two-updated-blood-glucose-monitoring-systems-an-evaluation-following-iso-15197-2013
#19
Stefan Pleus, Annette Baumstark, Delia Rittmeyer, Nina Jendrike, Cornelia Haug, Guido Freckmann
Objective For patients with diabetes, regular self-monitoring of blood glucose (SMBG) is essential to ensure adequate glycemic control. Therefore, accurate and reliable blood glucose measurements with SMBG systems are necessary. The international standard ISO 15197 describes requirements for SMBG systems, such as limits within which 95% of glucose results have to fall to reach acceptable system accuracy. The 2013 version of this standard sets higher demands, especially regarding system accuracy, than the currently still valid edition...
May 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26553641/space-experiment-cellular-responses-to-radiation-in-space-cellrad-hardware-and-biological-system-tests
#20
Christine E Hellweg, Shahana Dilruba, Astrid Adrian, Sebastian Feles, Claudia Schmitz, Thomas Berger, Bartos Przybyla, Luca Briganti, Markus Franz, Jürgen Segerer, Luis F Spitta, Bernd Henschenmacher, Bikash Konda, Sebastian Diegeler, Christa Baumstark-Khan, Corinna Panitz, Günther Reitz
One factor contributing to the high uncertainty in radiation risk assessment for long-term space missions is the insufficient knowledge about possible interactions of radiation with other spaceflight environmental factors. Such factors, e.g. microgravity, have to be considered as possibly additive or even synergistic factors in cancerogenesis. Regarding the effects of microgravity on signal transduction, it cannot be excluded that microgravity alters the cellular response to cosmic radiation, which comprises a complex network of signaling pathways...
November 2015: Life Sciences in Space Research
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