keyword
https://read.qxmd.com/read/38536596/pathologic-maternal-and-neonatal-outcomes-associated-with-programmed-embryo-transfer-potential-etiologies-and-strategies-for-prevention
#1
REVIEW
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In the first of two companion papers, we comprehensively reviewed the recent evidence in the primary literature, which addressed the increased prevalence of hypertensive disorders of pregnancy, late-onset or term preeclampsia, fetal overgrowth, postterm birth, and placenta accreta in women conceiving by in vitro fertilization. The preponderance of evidence implicated frozen embryo transfer cycles and, specifically, those employing programmed endometrial preparations, in the higher risk for these adverse maternal and neonatal pregnancy outcomes...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536594/pathologic-maternal-and-neonatal-outcomes-associated-with-programmed-embryo-transfer
#2
REVIEW
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In this first of two companion papers, we critically review the evidence recently published in the primary literature, which addresses adverse maternal and neonatal pregnancy outcomes associated with programmed embryo transfer cycles. We next consider whether these pathological pregnancy outcomes might be attributable to traditional risk factors, unknown parental factors, embryo culture, culture duration, or cryopreservation. Finally, in the second companion article, we explore potential etiologies and suggest strategies for prevention...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38534724/relationship-between-androgens-and-vascular-and-placental-function-during-pre-eclampsia
#3
REVIEW
Lara M Fernandes, Margarida Lorigo, Elisa Cairrao
Hypertensive disorders of pregnancy (HDP) represent a substantial risk to maternal and fetal health. Emerging evidence suggests an association between testosterone and pre-eclampsia (PE), potentially mediated through androgen receptors (AR). Nevertheless, the mechanism driving this association is yet to be elucidated. On the other hand, reports of transgender men's pregnancies offer a limited and insightful opportunity to understand the role of high androgen levels in the development of HDP. In this sense, a literature review was performed from a little over 2 decades (1998-2022) to address the association of testosterone levels with the development of HDP...
February 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534461/estrogen-and-progesterone-receptors-are-dysregulated-at-the-bph-5-mouse-preeclamptic-like-maternal-fetal-interface
#4
JOURNAL ARTICLE
Viviane C L Gomes, Bryce M Gilbert, Carolina Bernal, Kassandra R Crissman, Jenny L Sones
The etiopathogenesis of preeclampsia, a leading hypertensive disorder of pregnancy, has been proposed to involve an abnormal circulating sex hormone profile and misexpression of placental estrogen and progesterone receptors (ER and PR, respectively). However, existing research is vastly confined to third trimester preeclamptic placentas. Consequently, the placental-uterine molecular crosstalk and the dynamic ER and PR expression pattern in the peri-conception period remain overlooked. Herein, our goal was to use the BPH/5 mouse to elucidate pre-pregnancy and early gestation Er and Pr dynamics in a preeclamptic-like uterus...
March 16, 2024: Biology
https://read.qxmd.com/read/38534428/probiotics-supplementation-during-pregnancy-can-they-exert-potential-beneficial-effects-against-adverse-pregnancy-outcomes-beyond-gestational-diabetes-mellitus
#5
JOURNAL ARTICLE
Efthymios Poulios, Eleni Pavlidou, Sousana K Papadopoulou, Kalliopi Rempetsioti, Athanasios Migdanis, Maria Mentzelou, Maria Chatzidimitriou, Ioannis Migdanis, Odysseas Androutsos, Constantinos Giaginis
BACKGROUND: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics' healthy effects are related with the prevention of many diseases, as well as decreasing symptom severity. Currently, the most available data concerning their potential health effects are associated with metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may exert beneficial effects against diverse adverse pregnancy outcomes...
February 28, 2024: Biology
https://read.qxmd.com/read/38534046/the-late-effects-of-haematopoietic-stem-cell-transplants-in-paediatric-patients-a-25-year-review
#6
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38533990/primary-and-secondary-intracerebral-hemorrhage-in-pregnant-and-nonpregnant-young-adults-by-smash-up-criteria
#7
JOURNAL ARTICLE
Mehriban Sariyeva, Noora Haghighi, Amanda Mitchell, Whitney A Booker, Nils H Petersen, Andrea D Shields, Shivani Ghoshal, Sachin Agarwal, Soojin Park, Jan Claassen, E Sander Connolly, David J Roh, Eliza C Miller
BACKGROUND: Intracerebral hemorrhage (ICH) is a major cause of maternal morbidity, but its pathophysiology is poorly characterized. We investigated characteristics of pregnancy-associated ICH (P-ICH), compared with ICH in similar aged nonpregnant adults of both sexes. METHODS AND RESULTS: We performed a retrospective analysis of 134 adults aged 18 to 44 years admitted to our center with nontraumatic ICH from January 1, 2012, to December 31, 2021. We compared ICH characteristics among 3 groups: those with P-ICH (pregnant or within 12 months of end of pregnancy); nonpregnant women; and men...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533951/impact-of-an-impaired-maternal-fetal-environment-on-death-in-children-with-congenital-heart-defects-undergoing-surgery-in-denmark-from-1994-to-2018
#8
JOURNAL ARTICLE
Rasmus Kristensen, Camilla Omann, Charlotte K Ekelund, J William Gaynor, Vibeke E Hjortdal
BACKGROUND: Studies show that an impaired maternal-fetal environment (iMFE) increases the mortality risk in children with single-ventricle congenital heart defects (CHDs). We investigated the impact of an iMFE on death in children with various surgically corrected CHDs. METHODS AND RESULTS: In this nationwide register-based study, we examined the association between an iMFE (including preeclampsia, gestational hypertension, gestational diabetes, maternal smoking during pregnancy) and death in a large cohort of children with surgically corrected CHDs in Denmark (1994-2018)...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533846/longitudinal-management-of-cardiovascular-risk-factors-among-postpartum-women
#9
JOURNAL ARTICLE
Rebecca Lumsden, Courtney B Page, Matthew Phelan, Sarahn Wheeler, Neha Pagidipati
Background: Pregnancy-related cardiovascular (CV) conditions, including hypertensive disorders of pregnancy (HDP) and gestational diabetes (GDM), are associated with increased long-term CV risk. Methods: This retrospective cohort study defined the prevalence of HDP and GDM within a large, academic health system in the southeast United States between 2012 and 2015 and described health care utilization and routine CV screening up to 1-year following delivery among those with pregnancy-related CV conditions. Rates of follow-up visits and blood pressure, hemoglobin A1c (HbA1c), and lipid screening in the first postpartum year were compared by provider type and pregnancy-related CV condition...
March 27, 2024: Journal of Women's Health
https://read.qxmd.com/read/38533754/the-rs2018736-fibulin-5-polymorphism-as-a-determinant-for-pelvic-organ-prolapse-a-case-control-study
#10
JOURNAL ARTICLE
Juliana B Teixeira, Maria A T Bortolini, Rebecca S P Silva, Nilce C Batista, Carolina L Costa E Silva, Kristina Allen-Brady, Rodrigo A Castro
OBJECTIVE: Fibulin-5 is a connective tissue component and may play a role in pelvic organ prolapse (POP) pathogenesis. This study aimed to verify the association of the rs2018736 polymorphism of the fibulin-5 gene with POP in postmenopausal Brazilian women, and to determine the risk factors for POP. METHOD: This observational, cross-sectional, case-control study assessed postmenopausal women with advanced POP (stages III and IV) and control women (stages 0 and I) by examination and peripheral blood sample collection...
March 27, 2024: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/38533642/increased-risk-of-gestational-hypertension-by-periconceptional-exposure-to-ambient-air-pollution-and-effect-modification-by-prenatal-depression
#11
JOURNAL ARTICLE
Zhongzheng Niu, Rima Habre, Tingyu Yang, Xinci Chen, Mario Vigil, Karina Barragan, Fred Lurmann, Nathan R Pavlovic, Brendan H Grubbs, Claudia M Toledo-Corral, Jill Johnston, Genevieve F Dunton, Deborah Lerner, Nathana Lurvey, Laila Al-Marayati, Sandrah P Eckel, Carrie V Breton, Theresa M Bastain, Shohreh F Farzan
BACKGROUND: Air pollution has been associated with gestational hypertension (GH) and preeclampsia, but susceptible windows of exposure and potential vulnerability by comorbidities, such as prenatal depression, remain unclear. METHODS: We ascertained GH and preeclampsia cases in a prospective pregnancy cohort in Los Angeles, CA. Daily levels of ambient particles (with a diameter of ≤10 μm [PM10 ] or ≤2.5 μm [PM2.5 ]), nitrogen dioxide, and ozone were averaged for each week from 12 weeks preconception to 20 gestational weeks...
March 27, 2024: Hypertension
https://read.qxmd.com/read/38532505/maternal-immune-suppression-during-pregnancy-does-not-prevent-abnormal-behavior-in-offspring
#12
JOURNAL ARTICLE
Ashley Griffin, Teylor Bowles, Lucia Solis, Teryn Railey, Samer Beauti, Reanna Robinson, Shauna-Kay Spencer, James P Shaffery, Kedra Wallace
BACKGROUND: Offspring of hypertensive disorders of pregnancy are at an increased risk of developing neurodevelopmental and neurobehavioral disorders compared to offspring from non-affected pregnancies. Using rodent models of Preeclampsia (PreE; new onset of hypertension after 20 weeks gestation) and HELLP (hemolysis, elevated liver enzymes, and low platelets), we studied the behavioral outcome of their offspring in adolescence. METHODS: A subset of dams received Orencia, a T-cell activation inhibitor, as T cells have been associated with the induction of hypertension and inflammation during pregnancy...
March 26, 2024: Biology of Sex Differences
https://read.qxmd.com/read/38532461/placental-tlr-recognition-of-salivary-and-subgingival-microbiota-is-associated-with-pregnancy-complications
#13
JOURNAL ARTICLE
Kazune Pax, Nurcan Buduneli, Murat Alan, Pinar Meric, Onder Gurlek, Shareef M Dabdoub, Purnima S Kumar
BACKGROUND: Pre-term birth, the leading cause of neonatal mortality, has been associated with maternal periodontal disease and the presence of oral pathogens in the placenta. However, the mechanisms that underpin this link are not known. This investigation aimed to identify the origins of placental microbiota and to interrogate the association between parturition complications and immune recognition of placental microbial motifs. Video Abstract METHODS: Saliva, plaque, serum, and placenta were collected during 130 full-term (FT), pre-term (PT), or pre-term complicated by pre-eclampsia (PTPE) deliveries and subjected to whole-genome shotgun sequencing...
March 26, 2024: Microbiome
https://read.qxmd.com/read/38532420/recent-advances-in-endothelial-colony-forming-cells-from-the-transcriptomic-perspective
#14
REVIEW
Yaqiong Liu, Caomhán J Lyons, Christine Ayu, Timothy O'Brien
Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemic heart disease and peripheral artery disease. However, some barriers hinder the clinical application of ECFC therapeutics. One of the current obstacles is that ECFCs are dysfunctional due to the underlying disease states. ECFCs exhibit dysfunctional phenotypes in pathologic states, which include but are not limited to the following: premature neonates and pregnancy-related diseases, diabetes mellitus, cancers, haematological system diseases, hypoxia, pulmonary arterial hypertension, coronary artery diseases, and other vascular diseases...
March 26, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38531715/preterm-birth-increases-cerebral-palsy-hazards-in-children-of-mothers-with-chronic-hypertension-in-pregnancy
#15
JOURNAL ARTICLE
Yi-Chien Huang, Hung-Chih Lin, Yu-Tzu Chang, Ming-Luen Tsai, Yu-Chia Chang, Lan-Wan Wang
BACKGROUND: Children of mothers with chronic-hypertension in pregnancy have high rates of preterm-birth (<37 weeks of gestation) and small-for-gestational-age (SGA), both of which are risk factors of cerebral palsy (CP). This study investigated the cumulative risks of CP in children exposed to maternal chronic-hypertension vs. other types of hypertensive-disorders-of-pregnancy (HDP), and whether preterm-birth and SGA potentiate the antenatal impact of chronic-hypertension to increase CP hazards...
March 24, 2024: Pediatrics and Neonatology
https://read.qxmd.com/read/38531673/natural-proliferative-phase-frozen-embryo-transfer-a-new-approach-which-may-facilitate-scheduling-without-hindering-pregnancy-outcomes
#16
JOURNAL ARTICLE
Catarina Mendes Godinho, Sérgio Reis Soares, Sofia Gouveia Nunes, Juan M Mascarós Martínez, Samuel Santos-Ribeiro
STUDY QUESTION: How does a natural proliferative phase (NPP) strategy for frozen embryo transfer (FET) compare with the conventional artificial (AC) and natural (NC) endometrial preparation protocols in terms of live birth rates (LBR)? SUMMARY ANSWER: This study supports the hypothesis that, just as for NC, NPP-FET may be a superior alternative to AC in terms of LBR. WHAT IS KNOWN ALREADY: Although FETs are increasing worldwide, the optimal FET protocol is still largely controversial...
March 26, 2024: Human Reproduction
https://read.qxmd.com/read/38531392/characteristics-associated-with-trial-of-labor-among-patients-with-twin-pregnancies
#17
JOURNAL ARTICLE
Danielle T Cipres, Rachael Cowherd, Olivia H Barry, Liqi Chen, Lynn M Yee
OBJECTIVE: This study aimed to identify patient and provider factors associated with undergoing trial of labor among eligible patients with twin gestations. STUDY DESIGN: This retrospective cohort study of patients with twin gestations who received care at a large tertiary care center from 2000-2016 included individuals with live pregnancies greater than twenty-three weeks of gestation and cephalic-presenting twin. Patients with a prior uterine scar or contraindication to vaginal delivery were excluded from analyses...
March 26, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38531391/increased-rates-of-hypertensive-disorders-of-pregnancy-during-the-covid-19-pandemic
#18
JOURNAL ARTICLE
Colleen Sinnott, Taylor S Freret, Mark A Clapp, Sarah E Little
OBJECTIVE: Hypertensive disorders of pregnancy (HDP) are common complications associated with severe maternal and neonatal morbidity. One goal of prenatal care, especially at term, is to screen for HDP. As treatment of HDP centers on delivery when appropriate, timely diagnosis is crucial. We postulated that reduced in-person visits during the COVID-19 pandemic may have resulted in delayed diagnosis of HDP with concomitant higher rates of maternal morbidity. We sought to investigate the prevalence of HDP during the COVID-19 pandemic, as well as median gestational age at time of delivery as compared to the pre-pandemic median...
March 26, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38531390/factors-associated-with-maternal-morbidity-among-black-women-in-the-united-states
#19
JOURNAL ARTICLE
Catrine Ibrahim Ibrahim Sous, William Moravec, Emily A DeFranco, Elizabeth Kelly, Robert M Rossi
OBJECTIVE: Non-Hispanic Black people (NHBP) have a 3-fold higher rate of maternal mortality compared to other racial groups. Racial disparities in maternal morbidity are well described however there are substantial differences in cultural, economic, and social determinants of health among racial groups. We sought to study the, at-risk, non-Hispanic Black population as its own cohort to identify factors most associated with severe maternal morbidity (SMM). METHODS: This is a population-based retrospective case control study of all livebirths in the U...
March 26, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38530604/class-v-lupus-nephritis-recurrence-with-histologic-resolution-in-a-kidney-transplant-recipient-on-a-pregnancy-adapted-immunosuppression-protocol-a-lesson-for-the-clinical-nephrologist
#20
JOURNAL ARTICLE
Jorane-Tiana Robert, Ajay Rajaram, Pierre O Fiset, Chantal Bernard, Ratna Samanta, Shaifali Sandal
No abstract text is available yet for this article.
March 26, 2024: Journal of Nephrology
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