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Jaime Laqui-Estaña, Remigio López-Solís, Álvaro Peña-Neira, Marcela Medel-Marabolí, Elías Obreque-Slier
BACKGROUND: This study characterized the flavonoid and non-flavonoid phenolic composition of Carménère and Cabernet Sauvignon wines that were in contact with barrels, chips and staves during a 12-month aging period. The wines were evaluated by spectrophotometric (for total phenols, anthocyanins and tannins, colorant intensity, hue, CIElab parameters and fractionation into mono-, oligo- and polymer of proanthocyanidins) and HPLC-DAD analyses (for ellagitannins, gallotannins, anthocyanins and low molecular weight phenols)...
June 13, 2018: Journal of the Science of Food and Agriculture
Vanesa Stojanovska, Rachel M McQuade, Sarah Fraser, Monica Prakash, Shakuntla Gondalia, Rhian Stavely, Enzo Palombo, Vasso Apostolopoulos, Samy Sakkal, Kulmira Nurgali
Oxaliplatin is a platinum-based chemotherapeutic used for cancer treatment. Its use associates with peripheral neuropathies and chronic gastrointestinal side-effects. Oxaliplatin induces immunogenic cell death by provoking the presentation of damage associated molecular patterns. The damage associated molecular patterns high-mobility group box 1 (HMGB1) protein exerts pro-inflammatory cytokine-like activity and binds to toll-like receptors (namely TLR4). Gastrointestinal microbiota may influence chemotherapeutic efficacy and contribute to local and systemic inflammation...
2018: PloS One
Daniel Thomas Ginat, Daniel Lam, Andrew Scott Kuhn, Russell Reid
Several surgical options are available for treating the different types of craniosynostosis, including fronto-orbital advancement and remodeling, total or subtotal cranial vault remodeling, barrel stave osteotomy with cranial remodeling, endoscopic suturectomy, monobloc advancement and cranioplasty, and revision cranioplasty. High-resolution, low-dose CT with 3D reconstructed images and volumetric analysis can be useful for evaluating the craniofacial skeleton following surgery. The various types of craniosynostosis surgery and corresponding imaging findings are reviewed in this article...
June 6, 2018: Pediatric Neurosurgery
M Fanelli Kuczmarski, R T Pohlig, E Stave Shupe, A B Zonderman, M K Evans
OBJECTIVE: To determine the association of handgrip strength (HS) with protein intake, diet quality, and nutritional and cardiovascular biomarkers in African American and White adults. DESIGN: Cross-sectional wave 3 (2009-2013) of the cohort Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. PARTICIPANTS: Socioeconomically diverse urban population of 2,468 persons aged 33 to 71 years. MEASUREMENTS: Socio-demographic correlates, dietary intakes and biomarkers, HS, physical performance measures were collected...
2018: Journal of Nutrition, Health & Aging
Yusuke Sekiya, Shungo Sakashita, Keisuke Shimizu, Kenji Usui, Ryuji Kawano
We measured the current signal of the transmembrane model peptides using the barrel-stave, toroidal pore, and penetration models in order to establish a precise assignment of the channel signals. In addition, we analyzed the spike signals to estimate the membrane penetration of model cell-penetration peptides of different lengths.
May 23, 2018: Analyst
K M K de Vooght, M Lozano, J-L Bueno, A Alarcón, I Romera, K Suzuki, E Zhiburt, A Holbro, L Infanti, A Buser, H Hustinx, V Deneys, A Frélik, C Thiry, M Murphy, J Staves, K Selleng, A Greinacher, J M Kutner, C Bonet Bub, L Castilho, R Kaufman, M E Colling, P Perseghin, A Incontri, M Dassi, D Brilhante, A Macêdo, C Cserti-Gazdewich, J M Pendergrast, J Hawes, M N Lundgren, J R Storry, A Jain, N Marwaha, R R Sharma
No abstract text is available yet for this article.
May 20, 2018: Vox Sanguinis
Jeremy James Walsh, Michael E Tschakovsky
Engagement in regular bouts of exercise confers numerous positive effects on brain health across the lifespan. Acute bouts of exercise transiently improve cognitive function, while long-term exercise training stimulates brain plasticity, improves brain function, and helps to stave off neurological disease. The action of brain-derived neurotrophic factor (BDNF) is a candidate mechanism underlying these exercise-induced benefits and is the subject of considerable attention in the exercise-brain health literature...
May 18, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
ZhangFei Su, Muzaffar Shodiev, J Jay Leitch, Fatemeh Abbasi, Jacek Lipkowski
The insertion and ion conducting channel properties of alamethicin reconstituted into a 1, 2-di-O-phytanyl-sn-glycero-3-phosphatidylcholine (DPhPC) bilayer floating on the surface of gold (111) electrode modified with a 1-thio--D-glucose (-Tg) self-assembled monolayer were investigated using a combination of electrochemical impedance spectroscopy (EIS) and polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS). The hydrophilic -Tg monolayer separated the bilayer from the gold substrate and created a water-rich spacer region that better mimic natural cell membranes...
May 3, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Charles P Shahan, Taylor C Stavely, Martin A Croce, Timothy C Fabian, Louis J Magnotti
Since blunt cerebrovascular injury (BCVI) became increasingly recognized more than 20 years ago, significant improvements have been made in both diagnosis and treatment. Little is known regarding long-term functional outcomes in BCVI. The purpose of this study was to evaluate the impact of BCVI on those long-term outcomes. All patients with BCVI from 1996 to 2014 were identified from the trauma registry. Functional outcome was measured using the Boston University Activity Measure for Post-Acute Care. Multiple regression analysis was performed to identify potential predictors of outcomes...
April 1, 2018: American Surgeon
Rhian Stavely, Sarah Fraser, Shilpa Sharma, Ahmed A Rahman, Vanesa Stojanovska, Samy Sakkal, Vasso Apostolopoulos, Paul Bertrand, Kulmira Nurgali
Background: Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious stimuli, inducing secretion of 5-HT, which plays an important role in enteric reflexes and immunomodulation. In this study, we evaluated intestinal 5-HT levels in the Winnie mouse model of spontaneous chronic colitis, which closely replicates UC...
April 23, 2018: Inflammatory Bowel Diseases
Arun Mitra
Despite ongoing tensions in various parts of the world, the year 2017 ended on a positive note. The Treaty Prohibiting Nuclear Weapons (TPNW) was passed by the UN General Assembly on July 7, 2017, which will always be a red-letter day in history. It has raised many hopes for a future world without nuclear weapons and staved off the impending humanitarian catastrophe. Good health is a basic need of every individual. Therefore, each person yearns for a life free of violence and free of man-made catastrophes like the ones at Hiroshima and Nagasaki in 1945, which killed over two hundred thousand people and resulted in genetic mutations affecting generations thereafter...
March 7, 2018: Indian Journal of Medical Ethics
Mark H Yazer, Nancy M Dunbar, Claudia Cohn, Jessica Dillon, Howida Eldib, Bryon Jackson, Richard Kaufman, Michael F Murphy, Kerry O'Brien, Jay S Raval, Jansen Seheult, Julie Staves, Jonathan H Waters
BACKGROUND: Bleeding emergencies can complicate pregnancies. Understanding the disposition of the products that are issued in this clinical setting can help inform inventory levels at hospitals where obstetric patients are seen. STUDY DESIGN AND METHODS: Patients who had an obstetric hemorrhage of any etiology between January 2013 and June 2017, and whose resuscitation began with uncrossmatched red blood cells (RBCs) or emergency-issued plasma or platelets (PLT), were included...
March 7, 2018: Transfusion
Roneil G Malkani, Phyllis C Zee
No abstract text is available yet for this article.
February 1, 2018: Sleep Medicine Reviews
Anita D'Anselmo, Felice Giuliani, Federica Campopiano, Emanuele Carta, Alfredo Brancucci
Musical setticlavio (literally, seven clefs) reading refers to the ability to read (i.e., to say aloud, without to sing) the musical note labels in the 7 musical clefs. The present research report aims to investigate hemispheric asymmetries in such a basic musical ability, very poorly investigated in the domain of cognitive neurosciences. Sixty-three musicians underwent lateralized tachistoscopic presentation of musical notes on staves, 50% in the left and 50% in the right visual field, associated with each of the 7 musical clefs...
March 2018: Neuropsychology
Gregg M Stave
PURPOSE OF REVIEW: This review explores animal allergen exposure in research laboratories and other work settings, focusing on causes and prevention. RECENT FINDINGS: (1) Consistent with the hygiene hypothesis, there is new evidence that early childhood exposure to pets produces changes in the gut microbiome that likely lead to a lower risk of allergy. (2) Anaphylaxis from laboratory animal bites occurs more frequently than suggested by prior literature. (3) Animal allergens represent an occupational hazard in a wide variety of work settings ranging from fields that work with animals to public settings like schools and public transportation where allergens are brought into or are present in the workplace...
February 16, 2018: Current Allergy and Asthma Reports
J R Pharr, C A Coughenour, T J Bungum
OBJECTIVE: Obesity and physical inactivity are associated with increased rates of chronic diseases and conditions. However, the 'fit but fat' theory posits that cardiopulmonary fitness (or physical activity) can mitigate risks to health associated with obesity. The purpose of this study was to compare chronic diseases and conditions of highly active/obese women with inactive/normal weight women. STUDY DESIGN: This was a cross-sectional study of the 2015 Behavioral Risk Factor Surveillance System data...
March 2018: Public Health
Hao Yang, Daryl Staveness, Steven M Ryckbosch, Alison D Axtman, Brian A Loy, Alexander B Barnes, Vijay S Pande, Jacob Schaefer, Paul A Wender, Lynette Cegelski
Bryostatin 1 (henceforth bryostatin) is in clinical trials for the treatment of Alzheimer's disease and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and other therapeutic indications. Yet nothing is known about the conformation of bryostatin bound to its protein kinase C (PKC) target in a membrane microenvironment. As a result, efforts to design more efficacious, better tolerated, or more synthetically accessible ligands have been limited to structures that do not include PKC or membrane effects known to influence PKC-ligand binding...
January 24, 2018: ACS Central Science
Marie Fanelli Kuczmarski, Barry A Bodt, Emily Stave Shupe, Alan B Zonderman, Michele K Evans
The study's objective was to determine whether variations in the 2013 American College of Cardiology/American Heart Association 10-year risk for atherosclerotic cardiovascular disease (ASCVD) were associated with differences in food consumption and diet quality. Findings from the baseline wave of Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study 2004-2009, revealed participants consumed a Western diet. Diet quality measures, specifically the Healthy Eating Index (HEI)-2010, Dietary Approaches to Stop Hypertension (DASH) diet and the Mean Adequacy Ratio (MAR), based on two 24-h recalls collected during follow-up HANDLS studies from 2009-2013, were used...
January 31, 2018: Nutrients
Elizabeth A Stokes, Sarah Wordsworth, Julie Staves, Nicola Mundy, Jane Skelly, Kelly Radford, Simon J Stanworth
BACKGROUND: In an environment of limited health care resources, it is crucial for health care systems which provide blood transfusion to have accurate and comprehensive information on the costs of transfusion, incorporating not only the costs of blood products, but also their administration. Unfortunately, in many countries accurate costs for administering blood are not available. Our study aimed to generate comprehensive estimates of the costs of administering transfusions for the UK National Health Service...
April 2018: Transfusion
Karen V Stave Salgado, Ana M Rocca
Eosinophilic esophagitis is an immune-mediated chronic disease of the esophagus characterized by symptoms related to esophageal dysfunction and tissue eosinophilia. In the endoscopy, the esophageal mucosa may appear normal or show exudates, rings, edema, furrows, and strictures. Its management is based on elimination diet, topical corticosteroids and/or esophageal dilation. Atresia is the most common congenital alteration of the esophagus; it requires surgical repair and poses potential complications, such as gastroesophageal reflux, strictures, and esophageal dysmotility...
February 1, 2018: Archivos Argentinos de Pediatría
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