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https://www.readbyqxmd.com/read/29030954/an-international-investigation-into-ab-plasma-administration-in-hospitals-how-many-ab-plasma-units-were-infused-the-habswin-study
#1
Michelle P Zeller, Rebecca Barty, Nancy M Dunbar, Allahna Elahie, Peter Flanagan, Henk Garritsen, José Mauro Kutner, Monica B Pagano, Ryszard Pogłód, Thomas S Rogers, Julie Staves, Maria van Wordragen-Vlaswinkel, Jaap Jan Zwaginga, Michael F Murphy, Nancy M Heddle, Mark H Yazer
BACKGROUND: Typical practice is to transfuse group-specific plasma units; however, there are situations where group AB plasma (universal donor) is issued to group A, B, or O recipients. If demand for group AB plasma exceeds collections, there is potential for shortage. This project explored the patterns of group AB plasma utilization at hospitals around the world. STUDY DESIGN AND METHODS: The study had two phases: a survey that inquired about hospital group AB plasma inventory, policies, and transfusion practices and a retrospective review of 2014 calendar year data where participants submitted information on plasma disposition including ABO group of unit and recipient, transfusion location, and select indications...
October 14, 2017: Transfusion
https://www.readbyqxmd.com/read/29030244/pore-formation-and-the-key-factors-in-antibacterial-activity-of-aurein-1-2-and-llaa-inside-lipid-bilayers-a-molecular-dynamics-study
#2
Nasim Cheraghi, Mahdieh Hosseini, Sarah Mohammadinejad
Aurein 1.2 and LLAA are two antimicrobial peptides with different antibacterial activities (LLAA>Aurein 1.2), though their amino acid sequences are similar. In this manuscript, we study the key features for the different antibacterial activities of these peptides using molecular dynamics simulation. We find that in water, both peptides become disordered and LLAA is observed to have higher water-solubility, a feature which may contribute to enhancing its propensity to disrupt the bilayer and thus higher activity...
October 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28994123/systematic-review-with-meta-analysis-rifaximin-for-the-prophylaxis-of-spontaneous-bacterial-peritonitis
#3
REVIEW
A Goel, U Rahim, L H Nguyen, C Stave, M H Nguyen
BACKGROUND: The primary and secondary prevention of spontaneous bacterial peritonitis (SBP) is recommended in high-risk patients with cirrhosis. Several studies evaluating the efficacy of rifaximin for SBP prophylaxis have yielded conflicting results. Rifaximin has the potential advantage of preventing bacterial overgrowth and translocation without the systemic side effects of broad-spectrum antibiotics. AIM: To evaluate the efficacy of rifaximin in the primary and secondary prevention of SBP...
October 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28883505/channel-formation-and-membrane-deformation-via-sterol-aided-polymorphism-of-amphidinol-3
#4
Masayuki Iwamoto, Ayumi Sumino, Eri Shimada, Masanao Kinoshita, Nobuaki Matsumori, Shigetoshi Oiki
Amphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. Here, we examined the ion channel activity and membrane-embedded structure of AM3 using a lipid bilayer method and atomic force microscopy (AFM). AM3 exhibited large-conductance (~1 nS) and non-selective single-channel activity only when sterols were present in the membrane leaflet of the AM3-added side. The variable conductance suggests the formation of a multimeric barrel-stave pore. At high AM3 concentrations, giant-conductance "jumbo" channels (~40 nS) emerged...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840943/an-international-investigation-into-o-red-blood-cell-unit-administration-in-hospitals-the-group-o-utilization-patterns-group-study
#5
Michelle P Zeller, Rebecca Barty, Astrid Aandahl, Torunn O Apelseth, Jeannie Callum, Nancy M Dunbar, Allahna Elahie, Henk Garritsen, Helen Hancock, José Mauro Kutner, Belinda Manukian, Shuichi Mizuta, Makoto Okuda, Monica B Pagano, Ryszard Pogłód, Kylie Rushford, Kathleen Selleng, Claess Henning Sørensen, Ulrik Sprogøe, Julie Staves, Thorsten Weiland, Silvano Wendel, Erica M Wood, Leo van de Watering, Maria van Wordragen-Vlaswinkel, Alyssa Ziman, Jaap Jan Zwaginga, Michael F Murphy, Nancy M Heddle, Mark H Yazer
BACKGROUND: Transfusion of group O blood to non-O recipients, or transfusion of D- blood to D+ recipients, can result in shortages of group O or D- blood, respectively. This study investigated RBC utilization patterns at hospitals around the world and explored the context and policies that guide ABO blood group and D type selection practices. STUDY DESIGN AND METHODS: This was a retrospective study on transfusion data from the 2013 calendar year. This study included a survey component that asked about hospital RBC selection and transfusion practices and a data collection component where participants submitted information on RBC unit disposition including blood group and D type of unit and recipient...
October 2017: Transfusion
https://www.readbyqxmd.com/read/28796663/laboratory-animal-bite-anaphylaxis-a-national-survey-part-1-case-series-and-review-of-the-literature
#6
Gregg M Stave, Edward H Lee, Dennis J Darcey
OBJECTIVE: This study documents previously unreported cases of laboratory animal bite anaphylaxis in animal laboratory facilities in the United States. METHODS: An online survey was e-mailed to designated institutional officials at laboratory animal facilities identified by the National Institutes of Health Office of Laboratory Animal Welfare. RESULTS: One hundred ninety eight organizations responded and 15 organizations indicated that workers had experienced anaphylaxis following an animal bite...
August 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28782680/bilinguals-have-more-complex-eeg-brain-signals-in-occipital-regions-than-monolinguals
#7
John G Grundy, John A E Anderson, Ellen Bialystok
Brain signal complexity increases with development and is associated with better cognitive outcomes in older age. Research has also shown that bilinguals are able to stave off cognitive decline for longer periods of time than monolinguals, but no studies to date have examined whether bilinguals have more complex brain signals than monolinguals. Here we explored the hypothesis that bilingualism leads to greater brain signal complexity by examining multiscale entropy (MSE) in monolingual and bilingual young adults while EEG was recorded during a task-switching paradigm...
August 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28706386/alarming-emergence-molecular-characterization-and-outcome-of-blandm-1-in-patients-infected-with-multidrug-resistant-gram-negative-bacilli-in-a-tertiary-care-hospital
#8
Huma Naim, Meher Rizvi, Mohd Azam, Richa Gupta, Neelam Taneja, Indu Shukla, Haris M Khan
INTRODUCTION: This study was conducted to assess the prevalence of metallo-beta-lactamases (MBLs) in general and blaNDM-1 in particular. It also aimed at evaluating clinical characteristics and outcome in patients infected with MBLs. MATERIALS AND METHODS: A total of 116 carbapenem-resistant Gram-negative bacilli (CRGNB) were evaluated in the study. These CRGNB were tested for MBL production both phenotypically for MBLs and genotypically for blaNDM-1 gene by polymerase chain reaction (PCR)...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28642990/how-health-humanities-will-save-the-life-of-the-humanities
#9
Craig M Klugman
In the last decade, the humanities have been shrinking in number of students, percent of faculty, and in number of degrees awarded. Humanities students also earn lower salaries than their STEM-prepared peers. At the same time, the health humanities have been in ascendance over the last fifteen years. The number of majors, minors and certificates has increased 266% in that time frame, attracting large numbers of students and preparing future patients, lay caregivers, and health care providers to interact with a complicated and dehumanized medical system...
June 23, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28637294/over-time-impacts-of-pictorial-health-warning-labels-and-their-differences-across-smoker-subgroups-results-from-adult-smokers-in-canada-and-australia
#10
Kamala Swayampakala, James F Thrasher, Hua-Hie Yong, Gera E Nagelhout, Lin Li, Ron Borland, David Hammond, Richard J O'Connor, James W Hardin
Introduction: This study examines patterns of change in different smoker subgroups' responses to new pictorial health warning labels (HWLs) over the initial, two year post-implementation period in Canada, where HWLs include package inserts with cessation messages, and Australia, where "plain" packaging (i.e., prohibition of brand imagery) was also implemented. Methods: Data were collected from online consumer panels in Canada (nsmokers=3,153; nobservations=5,826) and Australia (nsmokers=2,699; nobservations=5,818) from September 2012 to September 2014, with approximately 1,000 adult smokers surveyed in each country every four months, using replenishment to maintain sample size...
June 16, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28610948/adaptive-capacity-an-evolutionary-neuroscience-model-linking-exercise-cognition-and-brain-health
#11
REVIEW
David A Raichlen, Gene E Alexander
The field of cognitive neuroscience was transformed by the discovery that exercise induces neurogenesis in the adult brain, with the potential to improve brain health and stave off the effects of neurodegenerative disease. However, the basic mechanisms underlying exercise-brain connections are not well understood. We use an evolutionary neuroscience approach to develop the adaptive capacity model (ACM), detailing how and why physical activity improves brain function based on an energy-minimizing strategy. Building on studies showing a combined benefit of exercise and cognitive challenge to enhance neuroplasticity, our ACM addresses two fundamental questions: (i) what are the proximate and ultimate mechanisms underlying age-related brain atrophy, and (ii) how do lifestyle changes influence the trajectory of healthy and pathological aging?...
July 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28609353/laboratory-animal-bite-anaphylaxis-a-national-survey-part-2-treatment-protocols
#12
Gregg M Stave, Edward H Lee, Dennis J Darcey
OBJECTIVE: This study documents current treatment protocols for laboratory animal bite anaphylaxis in the United States. METHODS: An online survey was e-mailed to designated institutional officials at laboratory animal facilities identified by the National Institutes of Health Office of Laboratory Animal Welfare. RESULTS: One hundred eighty-nine organizations responded to the question of whether they had a treatment protocol with 32% indicating that they had a protocol...
August 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28594095/electronic-remote-blood-issue-near-patient-blood-allocation-using-an-automated-blood-storage-system
#13
Sophie Staples, Clare O'Callaghan, Julie Staves, Michael F Murphy
No abstract text is available yet for this article.
August 2017: Transfusion
https://www.readbyqxmd.com/read/28590168/experimental-life-cycle-of-varestrongylus-eleguneniensis-nematoda-protostrongylidae-in-a-captive-reindeer-rangifer-tarandus-tarandus-and-a-muskox-ovibos-moschatus-moschatus
#14
P Kafle, J Sullivan, G G Verocai, S J Kutz
The life-cycle of a recently described protostrongylid lungworm, Varestrongylus eleguneniensis, which infects caribou, muskoxen, and moose from Arctic and boreal regions of North America, was completed experimentally for the first time. A native North American slug species, Deroceras laeve, was infected with the first-stage larvae (L1) isolated from the feces of wild muskoxen to generate third-stage larvae (L3). These were administered to a captive reindeer calf (250 L3) and an adult captive muskox (380 L3)...
October 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28585556/beneficial-effects-of-statins-on-the-rates-of-hepatic-fibrosis-hepatic-decompensation-and-mortality-in-chronic-liver-disease-a-systematic-review-and-meta-analysis
#15
REVIEW
Sehrish Kamal, Muhammad Ali Khan, Ankur Seth, George Cholankeril, Deepansh Gupta, Utkarsh Singh, Faisal Kamal, Colin W Howden, Christopher Stave, Satheesh Nair, Sanjaya K Satapathy, Aijaz Ahmed
OBJECTIVES: Statins may improve outcomes in patients with chronic liver disease (CLD). We conducted a systematic review and meta-analysis to evaluate the impact of statins in the setting of CLD. METHODS: We searched several databases from inception to 17 October 2016 to identify comparative studies evaluating the role of statins in CLD. Outcomes of interest were the associations between statin use and progression of fibrosis, development of hepatic decompensation in cirrhosis, and mortality in CLD...
October 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28534026/how-cells-can-control-their-size-by-pumping-ions
#16
Alan R Kay
The ability of all cells to set and regulate their size is a fundamental aspect of cellular physiology. It has been known for sometime but not widely so, that size stability in animal cells is dependent upon the operation of the sodium pump, through the so-called pump-leak mechanism (Tosteson and Hoffman, 1960). Impermeant molecules in cells establish an unstable osmotic condition, the Donnan effect, which is counteracted by the operation of the sodium pump, creating an asymmetry in the distribution of Na(+) and K(+) staving off water inundation...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28530825/effect-of-wood-aging-on-wine-mineral-composition-and-87-sr-86-sr-isotopic-ratio
#17
Ayse D Kaya, Raúl Bruno de Sousa, António S Curvelo-Garcia, Jorge M Ricardo-da-Silva, Sofia Catarino
The evolution of mineral composition and wine strontium isotopic ratio (87)Sr/(86)Sr (Sr IR) during wood aging were investigated. A red wine was aged in stainless steel tanks with French oak staves (Quercus sessiliflora Salisb.), with three industrial scale replicates. Sampling was carried out after 30, 60, and 90 days of aging, and the wines were evaluated in terms of general analysis, phenolic composition, total polysaccharides, multielement composition, and Sr IR. Li, Be, Mg, Al, Sc, Ti, V, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Rb, Sr, Y, Zr, Mo, Sb, Cs, Ba, Pr, Nd, Sm, Eu, Dy, Ho, Er, Yb, Lu, Tl, and Pb elements and (87)Sr/(86)Sr were determined by quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS) and Na, K, Ca, and Fe by flame atomic absorption spectrometry (FAAS)...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28520867/activity-of-ceftolozane-tazobactam-against-surveillance-and-problem-enterobacteriaceae-pseudomonas-aeruginosa-and-non-fermenters-from-the-british-isles
#18
David M Livermore, Shazad Mushtaq, Daniele Meunier, Katie L Hopkins, Robert Hill, Rachael Adkin, Aiysha Chaudhry, Rachel Pike, Peter Staves, Neil Woodford
Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against 'problem' isolates sent to the UK national reference laboratory from July 2015, when routine testing began. Methods: Susceptibility testing was by BSAC agar dilution with resistance mechanisms identified by PCR and interpretive reading. Results: Data were reviewed for 6080 BSAC surveillance isolates and 5473 referred organisms...
August 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28498340/nutritional-potential-of-selected-insect-species-reared-on-the-island-of-sumatra
#19
Anna Adámková, Jiří Mlček, Lenka Kouřimská, Marie Borkovcová, Tomáš Bušina, Martin Adámek, Martina Bednářová, Jan Krajsa
Inhabitants of the Indonesian island of Sumatra are faced with the problem of insufficient food supplies and the consequent risk of undernourishment and health issues. Edible insects as a traditional and readily available food source could be part of the solution. The nutritional value of insects depends on many factors, e.g., species, developmental stage, sex, diet, and climatic conditions. However, edible insects bred in Sumatra for human consumption have never before been assessed with regard to their nutritional value...
May 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28484399/biochemical-benefits-diagnosis-and-clinical-risks-evaluation-of-kratom
#20
REVIEW
Dimy Fluyau, Neelambika Revadigar
BACKGROUND: Kratom (Mitragyna speciosa) is a tropical tree with a long history of traditional use in parts of Africa and Southeast Asia. Kratom is also known as Thom, Thang, and Biak. Its leaves and the teas brewed from them have long been used by people in that region to manage pain and opioid withdrawal and to stave off fatigue. Kratom is actually consumed throughout the world for its stimulant effects and as an opioid substitute (in form of tea, chewed, smoked, or ingested in capsules)...
2017: Frontiers in Psychiatry
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