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https://www.readbyqxmd.com/read/29215649/a-craniosynostosis-massively-parallel-sequencing-panel-study-in-309-australian-and-new-zealand-patients-findings-and-recommendations
#1
Eric Lee, Trang Le, Ying Zhu, George Elakis, Anne Turner, William Lo, Hanka Venselaar, Carol-Ann Verrenkamp, Nicole Snow, David Mowat, Edwin Philip Kirk, Rani Sachdev, Janine Smith, Natasha Jane Brown, Mathew Wallis, Chris Barnett, Fiona McKenzie, Mary-Louise Freckmann, Felicity Collins, Maya Chopra, Nerine Gregersen, Ian Hayes, Sulekha Rajagopalan, Tiong Yang Tan, Zornitza Stark, Ravi Savarirayan, Alison Yeung, Lesley Adès, Michael Gattas, Kate Gibson, Michael Gabbett, David John Amor, Wanda Lattanzi, Simeon Boyd, Eric Haan, Mark Gianoutsos, Timothy Chilton Cox, Michael Francis Buckley, Tony Roscioli
PurposeThe craniosynostoses are characterized by premature fusion of one or more cranial sutures. The relative contribution of previously reported genes to craniosynostosis in large cohorts is unclear. Here we report on the use of a massively parallel sequencing panel in individuals with craniosynostosis without a prior molecular diagnosis.MethodsA 20-gene panel was designed based on the genes' association with craniosynostosis, and clinically validated through retrospective testing of an Australian and New Zealand cohort of 233 individuals with craniosynostosis in whom previous testing had not identified a causative variant within FGFR1-3 hot-spot regions or the TWIST1 gene...
December 7, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28990438/flash-glucose-monitoring-differences-between-intermittently-scanned-and-continuously-stored-data
#2
Stefan Pleus, Ulrike Kamecke, Manuela Link, Cornelia Haug, Guido Freckmann
The flash glucose monitoring system FreeStyle Libre (Abbott Diabetes Care Ltd., Witney, UK) measures interstitial glucose concentrations and continuously stores measurement values every 15 minutes. To obtain a current glucose reading, users have to scan the sensor with the reader. In a clinical trial, 5% of the scanned data showed relative differences of more than ±10% compared with continuously stored data points (median -0.5%). Such differences might impact results of studies using this system. It should be indicated whether scanned or continuously stored data were used for analyses...
October 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28931322/accuracy-evaluation-of-a-new-system-for-self-monitoring-of-blood-glucose-with-three-test-strip-lots-based-on-iso-15197-2013
#3
Annette Baumstark, Nina Jendrike, Stefan Pleus, Christina Liebing, Cornelia Haug, Guido Freckmann
No abstract text is available yet for this article.
September 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28913822/improved-glycemic-control-in-a-patient-group-performing-7-point-profile-self-monitoring-of-blood-glucose-and-intensive-data-documentation-an-open-label-multicenter-observational-study
#4
Jochen Sieber, Frank Flacke, Manuela Link, Cornelia Haug, Guido Freckmann
INTRODUCTION: Regular self-monitoring of blood glucose (SMBG) is recommended as an integral part of therapy for all patients with diabetes treated with insulin. In the current study, the effects on glycemic control of taking 7-point SMBG profiles and using a diabetes management system (DMA) on a smartphone were investigated. METHODS: In a 12-week, open-label, multicenter, observational study, 51 patients [26 with type 1 diabetes mellitus (T1DM) and 25 with type 2 diabetes mellitus (T2DM)] were instructed to perform SMBG at least seven times a day using DMA combined with the iBGStar ® SMBG system...
October 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28905659/comparative-handling-analysis-of-different-insulin-pump-systems
#5
Delia Waldenmaier, Katharina Schöllkopf, Antje Westhoff, Lutz Heinemann, Guido Freckmann
Insulin pumps are used by many patients with diabetes to manage their diabetes therapy. Adequate handling of the systems is important to avoid errors. In this study, one aspect of device handling-the number of steps required to operate the system-was evaluated for different insulin pump systems. Specific tasks that are usually performed by insulin pump users were simulated and all necessary actions were documented. Differences between the required numbers of steps strongly depended on the specific task. So did the level of guidance for these tasks provided by the systems...
September 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28745088/replacement-of-blood-glucose-measurements-by-measurements-with-systems-for-real-time-continuous-glucose-monitoring-rtcgm-or-cgm-with-intermittent-scanning-isccgm-a-german-view
#6
Guido Freckmann, Sandra Schlüter, Lutz Heinemann
No abstract text is available yet for this article.
July 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28704063/evaluation-of-accuracy-of-six-blood-glucose-monitoring-systems-and-modeling-of-possibly-related-insulin-dosing-errors
#7
Annette Baumstark, Nina Jendrike, Stefan Pleus, Cornelia Haug, Guido Freckmann
OBJECTIVE: Self-monitoring of blood glucose (BG) is an essential part of diabetes therapy. Accurate and reliable results from BG monitoring systems (BGMS) are important especially when they are used to calculate insulin doses. This study aimed at assessing system accuracy of BGMS and possibly related insulin dosing errors. RESEARCH DESIGN AND METHODS: System accuracy of six different BGMS (Accu-Chek(®) Aviva Nano, Accu-Chek Mobile, Accu-Chek Performa Nano, CONTOUR(®) NEXT LINK 2...
October 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28627219/accuracy-assessment-of-an-improved-version-of-an-established-blood-glucose-monitoring-system-for-self-testing-following-iso-15197-2013
#8
Ulrike Kamecke, Annette Baumstark, Nina Jendrike, Cornelia Haug, Guido Freckmann
No abstract text is available yet for this article.
July 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28587476/do-the-new-fda-guidance-documents-help-improving-performance-of-blood-glucose-monitoring-systems-compared-with-iso-15197
#9
Guido Freckmann, Annette Baumstark, Stefan Pleus
Recently, the Food and Drug Administration (FDA) published guidance documents for point-of-care testing (POCT) and over-the-counter (OTC) blood glucose monitoring systems (BGMS). These are expected to improve weaknesses of the already established ISO 15197:2013 standard accuracy evaluation for OTC BGMS; however, the proposed criteria and procedures rather raise new questions. As an example, the OTC guidance stipulates tighter accuracy criteria in the low glycemic range than the POCT guidance for no obvious reason...
November 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28459160/introduction-of-a-novel-smartphone-coupled-blood-glucose-monitoring-system
#10
Nina Jendrike, Annette Baumstark, Chieh-Hsiao Chen, Delia Rittmeyer, Cornelia Haug, Guido Freckmann
The novel system for self-monitoring of blood glucose (SMBG) PixoTest couples SMBG to a smartphone and does not require a separate glucose meter. The integrated system includes all components necessary for a glucose measurement, and owing to a colorimetric measurement principle, a smartphone camera can capture color changes and a software app calculates the corresponding glucose value. In the presented study, the system was evaluated in terms of system accuracy as described in ISO 15197:2013. It was shown to fulfill system accuracy requirements with 97-99% of results from three different reagent system lots within the accuracy limits and 100% of results within zone A of the consensus error grid...
November 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28443344/strengths-and-limitations-of-new-approaches-for-graphical-presentation-of-blood-glucose-monitoring-system-accuracy-data
#11
Stefan Pleus, Frank Flacke, Jochen Sieber, Cornelia Haug, Guido Freckmann
Graphical presentation of blood glucose monitoring systems' (BGMSs) accuracy typically includes difference plots (DPs). Recently, 3 new approaches were presented: radar plots (RPs), rectangle target plots (RTPs), and surveillance error grids (SEGs). BGMS data were modeled based on 3 scenarios that can be encountered in real life to highlight strengths and limitations of these approaches. Detailed assessment of BGMS data may be easier in plots with individual data points (DPs, RPs, SEGs), whereas RTPs may facilitate display of large amounts of data or comparison of BGMS...
November 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28355924/insulin-pump-occlusions-for-patients-who-have-been-around-the-infusion-block
#12
David C Klonoff, Guido Freckmann, Lutz Heinemann
No abstract text is available yet for this article.
May 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264584/clinicians-perspectives-of-therapeutic-alliance-in-face-to-face-and-telepractice-speech-language-pathology-sessions
#13
Anneka Freckmann, Monique Hines, Michelle Lincoln
PURPOSE: To investigate the face validity of a measure of therapeutic alliance for paediatric speech-language pathology and to determine whether a difference exists in therapeutic alliance reported by speech-language pathologists (SLPs) conducting face-to-face sessions, compared with telepractice SLPs or in their ratings of confidence with technology. METHOD: SLPs conducting telepractice (n = 14) or face-to-face therapy (n = 18) completed an online survey which included the Therapeutic Alliance Scales for Children - Revised (TASC-r) (Therapist Form) to rate clinicians' perceptions of rapport with up to three clients...
March 7, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28264186/analysis-of-randomized-cross-over-study-comparing-two-infusion-sets-for-csii-in-daily-life
#14
Eric Renard
In an article in Journal of Diabetes Science and Technology, Freckmann et al report an evaluation of 2 infusion sets used for CSII in daily life, both from Roche. Because the 2 catheters differed at the soft cannula level in terms of geometry and introducer needle, focus was made on pain at insertion. While no significant difference was noted on this primary endpoint, unplanned catheter changes occurred in close to 20% of cases also with both catheter models, mainly driven by apparent insulin delivery issues...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264178/bolus-calculator-safety-mandates-a-need-for-standards
#15
John Walsh, Guido Freckmann, Ruth Roberts, Lutz Heinemann
No abstract text is available yet for this article.
January 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28225633/accuracy-evaluation-of-four-blood-glucose-monitoring-systems-in-the-hands-of-intended-users-and-trained-personnel-based-on-iso-15197-requirements
#16
Guido Freckmann, Annette Baumstark, Nina Jendrike, Delia Rittmeyer, Stefan Pleus, Cornelia Haug
BACKGROUND: Self-monitoring of blood glucose (BG) is an integral part in the therapy of people with diabetes, which is why blood glucose monitoring systems (BGMS) have to fulfill minimum accuracy requirements. However, accuracy is often assessed by trained operators, although such assessments do not necessarily allow for drawing conclusions on accuracy in the hands of lay users. METHODS: The accuracy of 4 different BGMS (Accu-Chek(®) Active, Accu-Chek(®) Performa, Contour(®)Plus, and OneTouch(®) SelectSimple™) in the hands of lay users and trained study personnel was assessed in this study...
April 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28092684/biallelic-mutations-in-the-3-exonuclease-toe1-cause-pontocerebellar-hypoplasia-and-uncover-a-role-in-snrna-processing
#17
Rea M Lardelli, Ashleigh E Schaffer, Veerle R C Eggens, Maha S Zaki, Stephanie Grainger, Shashank Sathe, Eric L Van Nostrand, Zinayida Schlachetzki, Basak Rosti, Naiara Akizu, Eric Scott, Jennifer L Silhavy, Laura Dean Heckman, Rasim Ozgur Rosti, Esra Dikoglu, Anne Gregor, Alicia Guemez-Gamboa, Damir Musaev, Rohit Mande, Ari Widjaja, Tim L Shaw, Sebastian Markmiller, Isaac Marin-Valencia, Justin H Davies, Linda de Meirleir, Hulya Kayserili, Umut Altunoglu, Mary Louise Freckmann, Linda Warwick, David Chitayat, Susan Blaser, Ahmet Okay Çağlayan, Kaya Bilguvar, Huseyin Per, Christina Fagerberg, Henrik T Christesen, Maria Kibaek, Kimberly A Aldinger, David Manchester, Naomichi Matsumoto, Kazuhiro Muramatsu, Hirotomo Saitsu, Masaaki Shiina, Kazuhiro Ogata, Nicola Foulds, William B Dobyns, Neil C Chi, David Traver, Luigina Spaccini, Stefania Maria Bova, Stacey B Gabriel, Murat Gunel, Enza Maria Valente, Marie-Cecile Nassogne, Eric J Bennett, Gene W Yeo, Frank Baas, Jens Lykke-Andersen, Joseph G Gleeson
Deadenylases are best known for degrading the poly(A) tail during mRNA decay. The deadenylase family has expanded throughout evolution and, in mammals, consists of 12 Mg(2+)-dependent 3'-end RNases with substrate specificity that is mostly unknown. Pontocerebellar hypoplasia type 7 (PCH7) is a unique recessive syndrome characterized by neurodegeneration and ambiguous genitalia. We studied 12 human families with PCH7, uncovering biallelic, loss-of-function mutations in TOE1, which encodes an unconventional deadenylase...
March 2017: Nature Genetics
https://www.readbyqxmd.com/read/27605593/usability-of-medical-devices-for-patients-with-diabetes-who-are-visually-impaired-or-blind
#18
REVIEW
Lutz Heinemann, Diana Drossel, Guido Freckmann, Bernhard Kulzer
The estimation is that every third to fourth patient with diabetes suffers from some degree of diabetic retinopathy. Medical products for insulin administration (such as insulin pens and pumps) or glucose monitoring not optimized to the needs of these patients' represent a high barrier for optimal diabetes therapy in daily practice. To date, the number of devices suitable for visually impaired and blind patients with diabetes is scarce. This manuscript outlines the specific needs of this patient group with regard to systems for insulin administration, blood glucose measurement, and continuous glucose monitoring...
November 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27605591/randomized-cross-over-study-comparing-two-infusion-sets-for-csii-in-daily-life
#19
RANDOMIZED CONTROLLED TRIAL
Guido Freckmann, Stephan Arndt, Albrecht Fießelmann, Gerhard Klausmann, Kristina Pralle, Thomas Künsting, Bettina Petersen
BACKGROUND: Continuous subcutaneous insulin infusion (CSII) therapy is a valuable option especially for people with type 1 diabetes. Although insulin infusion sets (IIS) are essential components of most insulin pump systems, only few studies have been conducted on their performance and safety. In this study 2 IIS with soft cannulas were compared. METHODS: In an open-label, randomized, crossover, multicenter 8-week study 80 type 1 diabetic subjects on CSII (20-74 years, mean 46...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27566735/significance-and-reliability-of-mard-for-the-accuracy-of-cgm-systems
#20
Florian Reiterer, Philipp Polterauer, Michael Schoemaker, Guenther Schmelzeisen-Redecker, Guido Freckmann, Lutz Heinemann, Luigi Del Re
BACKGROUND: There is a need to assess the accuracy of continuous glucose monitoring (CGM) systems for several uses. Mean absolute relative difference (MARD) is the measure of choice for this. Unfortunately, it is frequently overlooked that MARD values computed with data acquired during clinical studies do not reflect the accuracy of the CGM system only, but are strongly influenced by the design of the study. Thus, published MARD values must be understood not as precise values but as indications with some uncertainty...
January 2017: Journal of Diabetes Science and Technology
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