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Neutrophils + volume + neonatal

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https://www.readbyqxmd.com/read/29028152/salivary-c-reactive-protein-and-mean-platelet-volume-in-diagnosis-of-late-onset-neonatal-pneumonia
#1
Ahmed Omran, Mohammed Ali, Mai H Saleh, Osama Zekry
BACKGROUND: Neonatal pneumonia is an important and major cause of neonatal morbidity and mortality worldwide therefore; its early detection plays a crucial role in successful therapy. Analysis of saliva as a non-invasive method for detection of neonatal diseases holds great promise for improving health care. Till now, salivary C-reactive protein (CRP), mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR) and platelets/lymphocytes ratio (PLR) have not been studied as markers of diagnosis in neonatal pneumonia...
October 13, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28892906/changes-in-haematological-parameters-in-newborns-born-to-preeclamptic-mothers-a-case-control-study-in-a-rural-hospital
#2
Kalavakuru Mouna, Shilpa Manigatta Doddagowda, Krishnappa Junjegowda, Latha Krishnamurthy
INTRODUCTION: Pregnancy is a physiological phenomenon. However, some women develop problems during pregnancy period, which puts both the mother's and the foetus health at risk. Hypertensive disorders of pregnancy are the type of the maternal diseases that can cause the most detrimental effects to the mother and foetus. AIMS: To determine the haematological parameters in neonates born to preeclamptic mothers. MATERIALS AND METHODS: It was a prospective case control study carried out on neonates born to preeclamptic mothers in our institute from March 2016 to November 2016...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28873345/neutrophil-chemotaxis-and-transcriptomics-in-term-and-preterm-neonates
#3
Steven L Raymond, Brittany J Mathias, Tyler J Murphy, Jaimar C Rincon, María Cecilia López, Ricardo Ungaro, Felix Ellett, Julianne Jorgensen, James L Wynn, Henry V Baker, Lyle L Moldawer, Daniel Irimia, Shawn D Larson
Neutrophils play a crucial role in combating life-threatening bacterial infections in neonates. Previous studies investigating neonatal cell function have been limited because of restricted volume sampling. Here, using novel microfluidic approaches, we provide the first description of neutrophil chemotaxis and transcriptomics from whole blood of human term and preterm neonates, as well as young adults. Ex vivo percent cell migration, neutrophil velocity, and directionality to N-formylmethionyl-leucyl-phenylalanine were measured from whole blood using time-lapse imaging of microfluidic chemotaxis...
September 1, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28734690/salivary-c-reactive-protein-mean-platelet-volume-and-neutrophil-lymphocyte-ratio-as-diagnostic-markers-for-neonatal-sepsis
#4
Ahmed Omran, Abdallah Maaroof, Mai H Saleh, Amina Abdelwahab
OBJECTIVE: To assess the applicability of salivary C-reactive protein (CRP), mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and platelet lymphocyte ratio (PLR) in the diagnosis of neonatal sepsis. METHODS: Prospective case-control study of 70 full-term neonates, 35 with sepsis (20 with proven sepsis and 15 with clinical sepsis) and 35 healthy controls. Serum and salivary CRP concentrations were measured by ELISA while MPV, NLR, and PLR were measured by automated blood cell counter...
July 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28157226/early-exposure-to-thirdhand-cigarette-smoke-affects-body-mass-and-the-development-of-immunity-in-mice
#5
Bo Hang, Antoine M Snijders, Yurong Huang, Suzaynn F Schick, Pin Wang, Yankai Xia, Christopher Havel, Peyton Jacob, Neal Benowitz, Hugo Destaillats, Lara A Gundel, Jian-Hua Mao
Thirdhand smoke (THS) is the fraction of cigarette smoke that persists in indoor environments after smoking. We investigated the effects of neonatal and adult THS exposure on bodyweight and blood cell populations in C57BL/6 J mice. At the end of neonatal exposure, THS-treated male and female mice had significantly lower bodyweight than their respective control mice. However, five weeks after neonatal exposure ended, THS-treated mice weighed the same as controls. In contrast, adult THS exposure did not change bodyweight of mice...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27123571/utility-of-neutrophil-volume-conductivity-scatter-vcs-parameter-changes-as-sepsis-screen-in-neonates
#6
T Abiramalatha, S Santhanam, J J Mammen, G Rebekah, M P Shabeer, J Choudhury, S C Nair
OBJECTIVE: The objective of this study was to determine changes in neutrophil volume conductivity scatter (VCS) parameters and their distribution widths (DW) in neonatal sepsis and to estimate their optimal cutoff levels using receiver operating characteristic (ROC) curves. STUDY DESIGN: In a cohort of neonates evaluated for sepsis, blood counts and blood culture were performed initially, with repeat counts and C-reactive protein (CRP) done after 24 to 48 h. Neutrophil VCS parameters from both the initial and repeat blood counts were analyzed...
September 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/26453507/protective-effects-of-gm-csf-in-experimental-neonatal-hypothyroidism
#7
R G Ahmed, M Abdel-Latif, F Ahmed
Hypothyroidism induced by methimazole (MMI), has a negative impact on the postnatal development. Neonatal Granulocyte Macrophage-Colony Stimulating Factor [GM-CSF; 50μg/kg, intramuscular injection at postnatal day (PND) 17] had been tested to ameliorate the effects of MMI [0.05%, (weight per volume; w/v), intraperitoneal injection at PND 15]-induced hypothyroidism in Wistar rats. The hypothyroid conditions due to the administration of MMI produced inhibitory effects on neonatal serum thyroxine (T4), 3,5,3'-triiodothyronine (T3), neutrophil count in bone marrow and blood, cerebellar glutathione (GSH) and acetylcholinesterase (AchE), although it induced stimulatory actions on serum thyrotropin (TSH), growth hormone (GH), insulin growth factor-II (IGF-II), tumor necrosis factor alpha (TNF-α), and cerebellar malondialdehyde (MDA) at PND 19...
December 2015: International Immunopharmacology
https://www.readbyqxmd.com/read/26411120/reference-haematological-values-for-full-term-healthy-newborns-from-rural-sindh-pakistan
#8
Waseem Pasha, Waqar Ali, Abdul Latif Khattak, Nayyer Ahmed, Muhammad Idris, Zameer Ahmad Nayyer
BACKGROUND: Normal values of complete blood counts show variation from region to region and between different ethnic groups. It is important to establish reference range for these values in our population for clinical use by our physicians. This descriptive cross sectional study aimed at establishing the normal reference values of complete blood counts in physically normal full term new-borns of Panu Aqil, Rural Sind, Pakistan. METHODS: The study was conducted at Combined Military Hospital, Panu Aqil Cantonment, from January 2010 to March 2011, on 316 term normal neonates selected on the basis of gestational age of 37 weeks or more with uneventful antenatal period...
April 2015: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/26190096/efficacy-of-new-leukocyte-parameters-versus-serum-c-reactive-protein-procalcitonin-and-interleukin-6-in-the-diagnosis-of-neonatal-sepsis
#9
H Tolga Çelik, Oytun Portakal, Şule Yiğit, Gülşen Hasçelik, Ayşe Korkmaz, Murat Yurdakök
BACKGROUND: The aim of this study was to investigate and compare the efficacy of the new leukocyte parameters mean neutrophil and monocyte volume (MNV, MMV), conductivity (MNC, MMC), scattering (MNS, MMS) and volume distribution width (NDW, MDW) with serum C-reactive protein (CRP), procalcitonin (PC) and interleukin (IL)-6 in the diagnosis of neonatal sepsis. METHODS: A total of 227 newborns (132 boys, 95 girls) were analyzed. There were 116 infants in the sepsis group (proven sepsis, n = 40; clinical sepsis, n = 76) and 111 in the control group...
February 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26014688/-values-of-c-reactive-protein-percentage-of-neutrophils-and-mean-platelet-volume-in-early-diagnosis-of-neonatal-sepsis
#10
Yao Yao, Yan Tu, Qi Lu
OBJECTIVE: To study the clinical values of C-reactive protein (CRP), the percentage of neutrophils, and mean platelet volume (MPV) in the diagnosis of neonatal sepsis. METHODS: A total of 315 neonates who were confirmed to have sepsis between January 2010 and May 2014 were divided into two groups: proven sepsis (with a positive blood culture; n=207) and clinical sepsis (with a clinical diagnosis; n=108). Within the same period, 132 hospitalized neonates with noninfectious diseases were enrolled as the control group...
May 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/25944264/cell-population-data-in-neonates-differences-by-age-group-and-associations-with-perinatal-factors
#11
J Lee, S Y Kim, W Lee, K Han, I K Sung
INTRODUCTION: Cell population data (CPD) describe physical parameters of white blood cell subpopulations and are reported to be of some value in the diagnosis of sepsis in neonates. Before using the CPD for diagnosing sepsis, the baseline features of the CPD distribution in healthy neonates should be clarified. The aim of this study was to compare the CPD distributions of healthy neonates and other age groups and to identify perinatal factors that are associated with changes in the CPD distribution of healthy neonates...
October 2015: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/25867529/neutrophil-chemotaxis-in-cord-blood-of-term-and-preterm-neonates-is-reduced-in-preterm-neonates-and-influenced-by-the-mode-of-delivery-and-anaesthesia
#12
Alexandra Birle, C Thomas Nebe, Sandra Hill, Karin Hartmann, Johannes Poeschl, Lutz Koch
Bacterial infections, even without any perinatal risk factors, are common in newborns, especially in preterm neonates. The aim of this study was to evaluate possible impairment of neutrophil chemotaxis in term and preterm neonates compared with adults as well as neonates with different modes of delivery and anaesthesia. We analysed the expression of the adhesion molecule L-Selectin as well as shape change, spontaneous and N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced transmigration of neutrophils in a flow cytometric assay of chemotaxis after spontaneous delivery with Cesarian Section (CS) under spinal anaesthesia (mepivacaine, sufentanil), epidural anaesthesia (ropivacaine or bupivacaine, sufentanil) or general anaesthesia (ketamine, thiopental, succinylcholine)...
2015: PloS One
https://www.readbyqxmd.com/read/25695243/-evaluation-of-the-diagnostic-utility-scale-of-nosep-1-and-nosep-1-modified-in-suspected-nosocomial-sepsis-in-preterm-infants
#13
Luz Angélica Rodríguez-Rojo, Juan Carlos Barrera-De León, José Guadalupe Maldonado-González, Álvaro Bautista-Vásquez, Elizette Margarita Yerenas-Esparza, Francisco de Asís Ibarra-Hernández
INTRODUCTION: Nosocomial sepsis in premature neonates entertains a high rate of mortality. Diagnosis and timely treatment increase the therapeutic response. The nosocomial sepsis neonate prediction (NOSEP-1) scale has been utilized to evaluate neonatal sepsis; this scale required modifications to improve its sensitivity and specificity (NOSEP-1 modified). OBJECTIVE: To determine the diagnostic usefulness of the NOSEP-1 and NOSEP-1 modified scales when nosocomial sepsis is suspected in premature neonates...
May 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/25634517/a-comprehensive-study-of-umbilical-cord-blood-cell-developmental-changes-and-reference-ranges-by-gestation-gender-and-mode-of-delivery
#14
L Glasser, N Sutton, M Schmeling, J T Machan
OBJECTIVE: The purpose of this study was to determine the normal hematological values in cord blood during gestation, the impact of the type of delivery and differences in gender. STUDY DESIGN: The database included 10 287 live births of 30-44 weeks gestation from cesarean or vaginal deliveries. Cord blood was collected into bags containing lyophilized heparin. Specimens were stored for 24 h or less and analyzed using the SysmexXE-2100. Data from cesarean births were used to evaluate developmental hematopoietic changes...
July 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/24874543/anti-neutrophil-antibody-enhances-the-neuroprotective-effects-of-g-csf-by-decreasing-number-of-neutrophils-in-hypoxic-ischemic-neonatal-rat-model
#15
Desislava M Doycheva, Tiffany Hadley, Li Li, Richard L Applegate, John H Zhang, Jiping Tang
OBJECTIVES: Neonatal hypoxia ischemia (HI) is an injury that can lead to neurological impairments such as behavioral and learning disabilities. Granulocyte-colony stimulating factor (G-CSF) has been demonstrated to be neuroprotective in ischemic stroke however it has also been shown to induce neutrophilia, ultimately exacerbating neuronal injury. Our hypothesis is that coadministration of anti-neutrophil antibody (Ab) with G-CSF will decrease blood neutrophil counts thereby reducing infarct volume and improving neurological function post HI brain injury...
September 2014: Neurobiology of Disease
https://www.readbyqxmd.com/read/24032003/hematological-profile-of-east-african-short-horn-zebu-calves-from-birth-to-51%C3%A2-weeks-of-age
#16
I Conradie van Wyk, A Goddard, B M de C Bronsvoort, J A W Coetzer, C Booth, O Hanotte, A Jennings, H Kiara, P Mashego, C Muller, G Pretorius, E J Poole, S M Thumbi, P G Toye, M E J Woolhouse, B L Penzhorn
This paper is the first attempt to accurately describe the hematological parameters for any African breed of cattle, by capturing the changes in these parameters over the first 12 months of an animal's life using a population-based sample of calves reared under field conditions and natural disease challenge. Using a longitudinal study design, a stratified clustered random sample of newborn calves was recruited into the IDEAL study and monitored at 5-weekly intervals until 51 weeks of age. The blood cell analysis performed at each visit included: packed cell volume; red cell count; red cell distribution width; mean corpuscular volume; mean corpuscular hemoglobin concentration; hemoglobin concentration; white cell count; absolute lymphocyte, eosinophil, monocyte, and neutrophil counts; platelet count; mean platelet volume; and total serum protein...
2012: Comparative Clinical Pathology
https://www.readbyqxmd.com/read/24027727/granulocyte-colony-stimulating-factor-for-preterms-with-sepsis-and-neutropenia-a-randomized-controlled-trial
#17
Jasodhara Chaudhuri, Souvik Mitra, Debadatta Mukhopadhyay, Swapna Chakraborty, Sukanta Chatterjee
BACKGROUND: Bacterial sepsis is one of the major causes of mortality in newborn infants. Mortality increases when sepsis is associated with neutropenia. MATERIALS AND METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled trial of recombinant human granulocyte colony-stimulating factor on preterm neonates (gestational age (GA) <34 weeks) with sepsis and absolute neutrophil count (ANC) of <1500 cells/mm(3). Mortality, duration of Neonatal Intensive Care Unit (NICU) stay, hematological parameters (ANC, platelet count, and total leukocyte count) were compared between the two groups...
October 2012: Journal of Clinical Neonatology
https://www.readbyqxmd.com/read/24004237/effects-of-intravenous-administration-of-polymyxin-b-in-neonatal-foals-with-experimental-endotoxemia
#18
RANDOMIZED CONTROLLED TRIAL
David M Wong, Brett A Sponseller, Cody J Alcott, Prince N Agbedanu, Chong Wang, Walter H Hsu
OBJECTIVE: To evaluate the effect of IV administration of polymyxin B on clinical and serum biochemical variables in foals with experimental endotoxemia. DESIGN: Prospective experimental study. ANIMALS: 14 healthy neonatal foals. PROCEDURES: Foals were randomly assigned to a treatment or control group and were administered a single dose of lipopolysaccharide (0.5 μg/kg [0.23 μg/lb]) IV over 30 minutes. The treatment group received polymyxin B (6,000 U/kg [2,727 U/lb], IV) immediately after completion of lipopolysaccharide infusion; the control group was administered an equal volume of saline (0...
September 15, 2013: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/23999070/phagocytosis-of-neonatal-pathogens-by-peripheral-blood-neutrophils-and-monocytes-from-newborn-preterm-and-term-infants
#19
COMPARATIVE STUDY
Amy Prosser, Julie Hibbert, Tobias Strunk, Chooi Heen Kok, Karen Simmer, Peter Richmond, David Burgner, Andrew Currie
BACKGROUND: Deficiencies in phagocytosis may contribute to the increased susceptibility of infants to early life infections. Data on phagocytosis of the major neonatal pathogens Staphylococcus epidermidis (SE), Staphylococcus aureus (SA), and Escherichia coli (EC) by preterm infant leukocytes are inconsistent. METHODS: Cord and <24-h peripheral blood were collected from very preterm (<30.1 wks gestational age (GA)) and term (37-42 wks GA) infants. Monocyte and neutrophil phagocytosis of pHrodo-labeled SE, SA, and EC were analyzed using a small-volume flow cytometry assay, with simultaneous characterization of surface activation marker expression...
November 2013: Pediatric Research
https://www.readbyqxmd.com/read/23834237/reference-intervals-for-common-coagulation-tests-of-preterm-infants-cme
#20
Robert D Christensen, Vickie L Baer, Diane K Lambert, Erick Henry, Sarah J Ilstrup, Sterling T Bennett
BACKGROUND: Fresh-frozen plasma (FFP) is sometimes administered to nonbleeding preterm neonates who are judged to be at risk for bleeding because they have abnormal coagulation tests. The benefits/risks of this practice are not well defined. One limitation to progress is lack of reference intervals for the common coagulation tests, thus limiting precision about whether coagulation tests are indeed abnormal. STUDY DESIGN AND METHODS: In a sequential observational study, fetal blood was drawn at preterm birth (≤ 34 weeks) from the umbilical vein near the placenta...
March 2014: Transfusion
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