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https://www.readbyqxmd.com/read/27123571/utility-of-neutrophil-volume-conductivity-scatter-vcs-parameter-changes-as-sepsis-screen-in-neonates
#1
T Abiramalatha, S Santhanam, J J Mammen, G Rebekah, M P Shabeer, J Choudhury, S C Nair
OBJECTIVE: The objective of this study was to determine changes in neutrophil volume conductivity scatter (VCS) parameters and their distribution widths (DW) in neonatal sepsis and to estimate their optimal cutoff levels using receiver operating characteristic (ROC) curves. STUDY DESIGN: In a cohort of neonates evaluated for sepsis, blood counts and blood culture were performed initially, with repeat counts and C-reactive protein (CRP) done after 24 to 48 h. Neutrophil VCS parameters from both the initial and repeat blood counts were analyzed...
September 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/26453507/protective-effects-of-gm-csf-in-experimental-neonatal-hypothyroidism
#2
R G Ahmed, M Abdel-Latif, F Ahmed
Hypothyroidism induced by methimazole (MMI), has a negative impact on the postnatal development. Neonatal Granulocyte Macrophage-Colony Stimulating Factor [GM-CSF; 50μg/kg, intramuscular injection at postnatal day (PND) 17] had been tested to ameliorate the effects of MMI [0.05%, (weight per volume; w/v), intraperitoneal injection at PND 15]-induced hypothyroidism in Wistar rats. The hypothyroid conditions due to the administration of MMI produced inhibitory effects on neonatal serum thyroxine (T4), 3,5,3'-triiodothyronine (T3), neutrophil count in bone marrow and blood, cerebellar glutathione (GSH) and acetylcholinesterase (AchE), although it induced stimulatory actions on serum thyrotropin (TSH), growth hormone (GH), insulin growth factor-II (IGF-II), tumor necrosis factor alpha (TNF-α), and cerebellar malondialdehyde (MDA) at PND 19...
December 2015: International Immunopharmacology
https://www.readbyqxmd.com/read/26411120/reference-haematological-values-for-full-term-healthy-newborns-from-rural-sindh-pakistan
#3
Waseem Pasha, Waqar Ali, Abdul Latif Khattak, Nayyer Ahmed, Muhammad Idris, Zameer Ahmad Nayyer
BACKGROUND: Normal values of complete blood counts show variation from region to region and between different ethnic groups. It is important to establish reference range for these values in our population for clinical use by our physicians. This descriptive cross sectional study aimed at establishing the normal reference values of complete blood counts in physically normal full term new-borns of Panu Aqil, Rural Sind, Pakistan. METHODS: The study was conducted at Combined Military Hospital, Panu Aqil Cantonment, from January 2010 to March 2011, on 316 term normal neonates selected on the basis of gestational age of 37 weeks or more with uneventful antenatal period...
April 2015: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/26190096/efficacy-of-new-leukocyte-parameters-versus-serum-c-reactive-protein-procalcitonin-and-interleukin-6-in-the-diagnosis-of-neonatal-sepsis
#4
H Tolga Çelik, Oytun Portakal, Şule Yiğit, Gülşen Hasçelik, Ayşe Korkmaz, Murat Yurdakök
BACKGROUND: The aim of this study was to investigate and compare the efficacy of the new leukocyte parameters mean neutrophil and monocyte volume (MNV, MMV), conductivity (MNC, MMC), scattering (MNS, MMS) and volume distribution width (NDW, MDW) with serum C-reactive protein (CRP), procalcitonin (PC) and interleukin (IL)-6 in the diagnosis of neonatal sepsis. METHODS: A total of 227 newborns (132 boys, 95 girls) were analyzed. There were 116 infants in the sepsis group (proven sepsis, n = 40; clinical sepsis, n = 76) and 111 in the control group...
February 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26014688/-values-of-c-reactive-protein-percentage-of-neutrophils-and-mean-platelet-volume-in-early-diagnosis-of-neonatal-sepsis
#5
Yao Yao, Yan Tu, Qi Lu
OBJECTIVE: To study the clinical values of C-reactive protein (CRP), the percentage of neutrophils, and mean platelet volume (MPV) in the diagnosis of neonatal sepsis. METHODS: A total of 315 neonates who were confirmed to have sepsis between January 2010 and May 2014 were divided into two groups: proven sepsis (with a positive blood culture; n=207) and clinical sepsis (with a clinical diagnosis; n=108). Within the same period, 132 hospitalized neonates with noninfectious diseases were enrolled as the control group...
May 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/25944264/cell-population-data-in-neonates-differences-by-age-group-and-associations-with-perinatal-factors
#6
J Lee, S Y Kim, W Lee, K Han, I K Sung
INTRODUCTION: Cell population data (CPD) describe physical parameters of white blood cell subpopulations and are reported to be of some value in the diagnosis of sepsis in neonates. Before using the CPD for diagnosing sepsis, the baseline features of the CPD distribution in healthy neonates should be clarified. The aim of this study was to compare the CPD distributions of healthy neonates and other age groups and to identify perinatal factors that are associated with changes in the CPD distribution of healthy neonates...
October 2015: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/25867529/neutrophil-chemotaxis-in-cord-blood-of-term-and-preterm-neonates-is-reduced-in-preterm-neonates-and-influenced-by-the-mode-of-delivery-and-anaesthesia
#7
Alexandra Birle, C Thomas Nebe, Sandra Hill, Karin Hartmann, Johannes Poeschl, Lutz Koch
Bacterial infections, even without any perinatal risk factors, are common in newborns, especially in preterm neonates. The aim of this study was to evaluate possible impairment of neutrophil chemotaxis in term and preterm neonates compared with adults as well as neonates with different modes of delivery and anaesthesia. We analysed the expression of the adhesion molecule L-Selectin as well as shape change, spontaneous and N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced transmigration of neutrophils in a flow cytometric assay of chemotaxis after spontaneous delivery with Cesarian Section (CS) under spinal anaesthesia (mepivacaine, sufentanil), epidural anaesthesia (ropivacaine or bupivacaine, sufentanil) or general anaesthesia (ketamine, thiopental, succinylcholine)...
2015: PloS One
https://www.readbyqxmd.com/read/25695243/-evaluation-of-the-diagnostic-utility-scale-of-nosep-1-and-nosep-1-modified-in-suspected-nosocomial-sepsis-in-preterm-infants
#8
Luz Angélica Rodríguez-Rojo, Juan Carlos Barrera-De León, José Guadalupe Maldonado-González, Álvaro Bautista-Vásquez, Elizette Margarita Yerenas-Esparza, Francisco de Asís Ibarra-Hernández
INTRODUCTION: Nosocomial sepsis in premature neonates entertains a high rate of mortality. Diagnosis and timely treatment increase the therapeutic response. The nosocomial sepsis neonate prediction (NOSEP-1) scale has been utilized to evaluate neonatal sepsis; this scale required modifications to improve its sensitivity and specificity (NOSEP-1 modified). OBJECTIVE: To determine the diagnostic usefulness of the NOSEP-1 and NOSEP-1 modified scales when nosocomial sepsis is suspected in premature neonates...
May 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/25634517/a-comprehensive-study-of-umbilical-cord-blood-cell-developmental-changes-and-reference-ranges-by-gestation-gender-and-mode-of-delivery
#9
L Glasser, N Sutton, M Schmeling, J T Machan
OBJECTIVE: The purpose of this study was to determine the normal hematological values in cord blood during gestation, the impact of the type of delivery and differences in gender. STUDY DESIGN: The database included 10 287 live births of 30-44 weeks gestation from cesarean or vaginal deliveries. Cord blood was collected into bags containing lyophilized heparin. Specimens were stored for 24 h or less and analyzed using the SysmexXE-2100. Data from cesarean births were used to evaluate developmental hematopoietic changes...
July 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/24874543/anti-neutrophil-antibody-enhances-the-neuroprotective-effects-of-g-csf-by-decreasing-number-of-neutrophils-in-hypoxic-ischemic-neonatal-rat-model
#10
Desislava M Doycheva, Tiffany Hadley, Li Li, Richard L Applegate, John H Zhang, Jiping Tang
OBJECTIVES: Neonatal hypoxia ischemia (HI) is an injury that can lead to neurological impairments such as behavioral and learning disabilities. Granulocyte-colony stimulating factor (G-CSF) has been demonstrated to be neuroprotective in ischemic stroke however it has also been shown to induce neutrophilia, ultimately exacerbating neuronal injury. Our hypothesis is that coadministration of anti-neutrophil antibody (Ab) with G-CSF will decrease blood neutrophil counts thereby reducing infarct volume and improving neurological function post HI brain injury...
September 2014: Neurobiology of Disease
https://www.readbyqxmd.com/read/24032003/hematological-profile-of-east-african-short-horn-zebu-calves-from-birth-to-51%C3%A2-weeks-of-age
#11
I Conradie van Wyk, A Goddard, B M de C Bronsvoort, J A W Coetzer, C Booth, O Hanotte, A Jennings, H Kiara, P Mashego, C Muller, G Pretorius, E J Poole, S M Thumbi, P G Toye, M E J Woolhouse, B L Penzhorn
This paper is the first attempt to accurately describe the hematological parameters for any African breed of cattle, by capturing the changes in these parameters over the first 12 months of an animal's life using a population-based sample of calves reared under field conditions and natural disease challenge. Using a longitudinal study design, a stratified clustered random sample of newborn calves was recruited into the IDEAL study and monitored at 5-weekly intervals until 51 weeks of age. The blood cell analysis performed at each visit included: packed cell volume; red cell count; red cell distribution width; mean corpuscular volume; mean corpuscular hemoglobin concentration; hemoglobin concentration; white cell count; absolute lymphocyte, eosinophil, monocyte, and neutrophil counts; platelet count; mean platelet volume; and total serum protein...
2012: Comparative Clinical Pathology
https://www.readbyqxmd.com/read/24027727/granulocyte-colony-stimulating-factor-for-preterms-with-sepsis-and-neutropenia-a-randomized-controlled-trial
#12
Jasodhara Chaudhuri, Souvik Mitra, Debadatta Mukhopadhyay, Swapna Chakraborty, Sukanta Chatterjee
BACKGROUND: Bacterial sepsis is one of the major causes of mortality in newborn infants. Mortality increases when sepsis is associated with neutropenia. MATERIALS AND METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled trial of recombinant human granulocyte colony-stimulating factor on preterm neonates (gestational age (GA) <34 weeks) with sepsis and absolute neutrophil count (ANC) of <1500 cells/mm(3). Mortality, duration of Neonatal Intensive Care Unit (NICU) stay, hematological parameters (ANC, platelet count, and total leukocyte count) were compared between the two groups...
October 2012: Journal of Clinical Neonatology
https://www.readbyqxmd.com/read/24004237/effects-of-intravenous-administration-of-polymyxin-b-in-neonatal-foals-with-experimental-endotoxemia
#13
RANDOMIZED CONTROLLED TRIAL
David M Wong, Brett A Sponseller, Cody J Alcott, Prince N Agbedanu, Chong Wang, Walter H Hsu
OBJECTIVE: To evaluate the effect of IV administration of polymyxin B on clinical and serum biochemical variables in foals with experimental endotoxemia. DESIGN: Prospective experimental study. ANIMALS: 14 healthy neonatal foals. PROCEDURES: Foals were randomly assigned to a treatment or control group and were administered a single dose of lipopolysaccharide (0.5 μg/kg [0.23 μg/lb]) IV over 30 minutes. The treatment group received polymyxin B (6,000 U/kg [2,727 U/lb], IV) immediately after completion of lipopolysaccharide infusion; the control group was administered an equal volume of saline (0...
September 15, 2013: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/23999070/phagocytosis-of-neonatal-pathogens-by-peripheral-blood-neutrophils-and-monocytes-from-newborn-preterm-and-term-infants
#14
COMPARATIVE STUDY
Amy Prosser, Julie Hibbert, Tobias Strunk, Chooi Heen Kok, Karen Simmer, Peter Richmond, David Burgner, Andrew Currie
BACKGROUND: Deficiencies in phagocytosis may contribute to the increased susceptibility of infants to early life infections. Data on phagocytosis of the major neonatal pathogens Staphylococcus epidermidis (SE), Staphylococcus aureus (SA), and Escherichia coli (EC) by preterm infant leukocytes are inconsistent. METHODS: Cord and <24-h peripheral blood were collected from very preterm (<30.1 wks gestational age (GA)) and term (37-42 wks GA) infants. Monocyte and neutrophil phagocytosis of pHrodo-labeled SE, SA, and EC were analyzed using a small-volume flow cytometry assay, with simultaneous characterization of surface activation marker expression...
November 2013: Pediatric Research
https://www.readbyqxmd.com/read/23834237/reference-intervals-for-common-coagulation-tests-of-preterm-infants-cme
#15
Robert D Christensen, Vickie L Baer, Diane K Lambert, Erick Henry, Sarah J Ilstrup, Sterling T Bennett
BACKGROUND: Fresh-frozen plasma (FFP) is sometimes administered to nonbleeding preterm neonates who are judged to be at risk for bleeding because they have abnormal coagulation tests. The benefits/risks of this practice are not well defined. One limitation to progress is lack of reference intervals for the common coagulation tests, thus limiting precision about whether coagulation tests are indeed abnormal. STUDY DESIGN AND METHODS: In a sequential observational study, fetal blood was drawn at preterm birth (≤ 34 weeks) from the umbilical vein near the placenta...
March 2014: Transfusion
https://www.readbyqxmd.com/read/23611502/factors-affecting-the-severity-of-necrotizing-enterocolitis
#16
Cheryl A Miner, Susan Fullmer, Dennis L Eggett, Robert D Christensen
OBJECTIVE: The severity of necrotizing enterocolitis (NEC) ranges from mild to rapidly fatal. However, the factors determining the severity are not known. Our objective was to identify statistical associations with NEC severity using a large database. METHOD: We conducted a retrospective, multi-institutional, multiyear, study of neonates with confirmed NEC. RESULTS: Two-hundred-twenty neonates with Bell's stage ≥ II NEC had 225 NEC episodes (157 stage II and 68 stage III)...
November 2013: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/22938598/neutrophil-volume-conductivity-and-scatter-parameters-with-effective-modeling-of-molecular-activity-statistical-program-gives-better-results-in-neonatal-sepsis
#17
I H Celik, G Demirel, D Sukhachev, O Erdeve, U Dilmen
INTRODUCTION: Neonatal sepsis remains an important clinical syndrome despite advances in neonatology. Current hematology analyzers can determine cell volume (V), conductivity for internal composition of cell (C) and light scatter for cytoplasmic granularity and nuclear structure (S), and standard deviations which are effective in the diagnosis of sepsis. Statistical models can be used to strengthen the diagnosis. Effective modeling of molecular activity (EMMA) uses combinatorial algorithm of the selection parameters for regression equation based on modified stepwise procedure...
February 2013: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/22770103/necrotizing-enterocolitis-old-problem-with-new-hope
#18
REVIEW
Shu-Fen Wu, Michael Caplan, Hung-Chih Lin
The incidence of necrotizing enterocolitis (NEC) and mortality rate associated with this disease are not decreasing despite more than three decades of intensive research investigation and advances in neonatal intensive care. Although the etiology of NEC is not clearly elucidated, the most accepted hypothesis at present is that enteral feeding in the presence of intestinal hypoxia-ischemia-reperfusion, and colonization with pathogens provokes an inappropriately accentuated inflammatory response by the immature intestinal epithelial cells of the preterm neonate...
June 2012: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/22289860/automated-determination-of-neutrophil-vcs-parameters-in-diagnosis-and-treatment-efficacy-of-neonatal-sepsis
#19
Istemi H Celik, Gamze Demirel, Hatice T Aksoy, Omer Erdeve, Ece Tuncer, Zeynep Biyikli, Ugur Dilmen
INTRODUCTION: The Coulter LH780 hematology analyzer can evaluate mean neutrophil volume (MNV), conductivity (MNC), scatter (MNS), and distribution width (DW). We sought to investigate the value of volume, conductivity, and scatter (VCS) parameters in diagnosis and treatment efficacy of neonatal sepsis. RESULTS: We observed significant increases in MNV, volume distribution width (VDW), conductivity distribution width (CDW), and significant decreases in MNC and MNS in septic newborns...
January 2012: Pediatric Research
https://www.readbyqxmd.com/read/21703558/complete-blood-count-reference-values-of-cord-blood-in-taiwan-and-the-influence-of-gender-and-delivery-route-on-them
#20
Yu-Hsun Chang, Shang-Hsien Yang, Tso-Fu Wang, Teng-Yi Lin, Kuo-Liang Yang, Shu-Huey Chen
BACKGROUND: Cord blood banking has become more popular in recent years. Checking cord blood complete blood count (CBC) and white blood cell (WBC) differential counts (DCs) is essential before cryopreserving the cord blood units. Therefore, establishing the normal reference values of cord blood CBC and WBC DC is important in clinical practice and research. OBJECTIVES: To obtain a large-scale population-based normal CBC and WBC DC reference values of healthy neonates' cord blood from a public cord blood bank and to investigate the influence of the gender and delivery route...
June 2011: Pediatrics and Neonatology
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