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https://www.readbyqxmd.com/read/28424660/ccl2-monocyte-chemoattractant-protein-1-and-parathyroid-hormone-action-on-bone
#1
REVIEW
Jawed Akhtar Siddiqui, Nicola C Partridge
Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coupled receptors. Two well-described chemokine families (CXC and CC) are known to regulate the localization and trafficking of immune cells in cases of injury, infection, and tumors. Monocyte chemoattractant protein 1 (MCP-1/CCL2) is one of the important chemokines from the CC family that controls migration and infiltration of monocytes/macrophages during inflammation...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28420437/bidirectional-nucleolar-dysfunction-in-c9orf72-frontotemporal-lobar-degeneration
#2
Sarah Mizielinska, Charlotte E Ridler, Rubika Balendra, Annora Thoeng, Nathan S Woodling, Friedrich A Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge, Adrian M Isaacs
An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and dipeptide repeat (DPR) proteins, generated by repeat-associated non-ATG translation. The arginine-rich DPR proteins poly(glycine-arginine or GR) and poly(proline-arginine or PR) are potently neurotoxic and can localise to the nucleolus when expressed in cells, resulting in enlarged nucleoli with disrupted functionality...
April 18, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28419442/characterization-of-runx2-phosphorylation-sites-required-for-tgf-%C3%AE-1-mediated-stimulation-of-matrix-metalloproteinase-13-expression-in-osteoblastic-cells
#3
B Arumugam, M Vairamani, N C Partridge, N Selvamurugan
Transforming growth factor-beta1 (TGF-β1), a highly abundant growth factor in skeletal tissues, stimulates matrix metalloproteinase-13 (MMP-13) expression in osteoblastic cells. MMP-13 plays a critical role in bone remodeling. Runx2, a bone transcription factor, is required for TGF-β1-mediated stimulation of MMP-13 expression in osteoblastic cells. In this study, the molecular mechanism responsible for TGF-β1-stimulation of MMP-13 expression via Runx2 in osteoblastic cells was elucidated. TGF-β1 stimulated the phosphorylation of Runx2 at serine amino acids, and ERK inhibition blocked this effect in rat (UMR106-01) and human (MG-63) osteoblastic cells...
April 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28408620/oncofertility-fertile-ground-for-conflict-between-patient-autonomy-and-medical-values
#4
Sarah K Walsh, Elizabeth S Ginsburg, Lisa Soleymani Lehmann, Ann H Partridge
Oncofertility is a unique, multidisciplinary field that serves to bridge the gap between available fertility resources and the special reproductive needs of cancer patients. Oncofertility is a growing field due to the increasing number of survivors, development of new oncologic therapies, extension of duration of therapies, and development and refinement of reproductive therapies. While the technologies and demand for services expand, clinicians need to be appropriately prepared for dealing with various clinical scenarios that may require ethical deliberation...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28408487/tspan2-a-tetraspanin-protein-involved-in-oligodendrogenesis-and-cancer-metastasis
#5
REVIEW
Ibrahim H Yaseen, Peter N Monk, Lynda J Partridge
Tetraspanin 2 (Tspan2) is one of the less well-characterised members of the tetraspanin superfamily, and its precise function in different human tissue types remains to be explored. Initial studies have highlighted its possible association in neuroinflammation and carcinogenesis. In the central nervous system, Tspan2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility and invasion functions...
April 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28407503/parkinsonian-signs-are-a-risk-factor-for-falls
#6
Nabila Dahodwala, Chinwe Nwadiogbu, Whitney Fitts, Helen Partridge, Jason Karlawish
BACKGROUND: Parkinsonian signs are common, non-specific findings in older adults and associated with increased rates of dementia and mortality. It is important to understand which motor outcomes are associated with parkinsonian signs. OBJECTIVES: To determine the role of parkinsonian signs on fall rates among older adults. METHODS: We conducted a longitudinal study of primary care patients from the University of Pennsylvania Health System...
April 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28397515/prevalence-and-renal-pathology-of-pathogenic-i-leptospira-i-spp-in-wildlife-in-abeokuta-ogun-state-nigeria
#7
Olusola L Ajayi, Richard E Antia, Olufemi E Ojo, Olajoju J Awoyomi, Latifa A Oyinlola, Oluwabusola G Ojebiyi
There is paucity of information on the prevalence of leptospirosis in wildlife in Nigeria. This study investigated the prevalence and renal pathology of leptospirosis in wild animals in Southwest Nigeria. One hundred and five kidney samples were examined from 10 different wildlife species (antelope) greater cane rat (GCR), hare, African giant rat (AGR), tree hyrax, civet cat, monitor lizard, python, bushbuck and partridge) using a combination of Ellinghausen McCullough Johnson Harris (EMJH) medium, microscopic agglutination test (MAT), Warthin- Starry silver stain (WSss) and immunohistochemistry...
March 24, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/28373570/effects-of-systemic-multiexon-skipping-with-peptide-conjugated-morpholinos-in-the-heart-of-a-dog-model-of-duchenne-muscular-dystrophy
#8
Yusuke Echigoya, Akinori Nakamura, Tetsuya Nagata, Nobuyuki Urasawa, Kenji Rowel Q Lim, Nhu Trieu, Dharminder Panesar, Mutsuki Kuraoka, Hong M Moulton, Takashi Saito, Yoshitsugu Aoki, Patrick Iversen, Peter Sazani, Ryszard Kole, Rika Maruyama, Terry Partridge, Shin'ichi Takeda, Toshifumi Yokota
Duchenne muscular dystrophy (DMD) is a lethal genetic disorder caused by an absence of the dystrophin protein in bodywide muscles, including the heart. Cardiomyopathy is a leading cause of death in DMD. Exon skipping via synthetic phosphorodiamidate morpholino oligomers (PMOs) represents one of the most promising therapeutic options, yet PMOs have shown very little efficacy in cardiac muscle. To increase therapeutic potency in cardiac muscle, we tested a next-generation morpholino: arginine-rich, cell-penetrating peptide-conjugated PMOs (PPMOs) in the canine X-linked muscular dystrophy in Japan (CXMDJ) dog model of DMD...
April 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28365832/prognosis-of-pregnancy-associated-breast-cancer
#9
REVIEW
Guek Eng Lee, Erica L Mayer, Ann Partridge
Conventionally, breast cancer diagnosed during pregnancy and within the years following have been referred to collectively as pregnancy-associated breast cancer. However, increasing evidence suggests that breast cancer diagnosed during pregnancy is a different entity from that diagnosed postpartum, both in terms of prognosis and biology. Given the increasing number of women who find themselves diagnosed with breast cancer during or following a pregnancy, future research and discussion should separate these two into distinct groups: breast cancer diagnosed during pregnancy and breast cancer diagnosed postpartum in an effort to enhance our understanding to inform and improve clinical management and counseling...
April 1, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28364657/genetic-models-of-c9orf72-what-is-toxic
#10
REVIEW
Thomas G Moens, Linda Partridge, Adrian M Isaacs
A hexanucleotide repeat expansion in the gene C9orf72 is the most common genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia. Pathogenesis may occur either due to loss of function of the C9orf72 gene, or a toxic gain of function, via the production of repetitive sense and antisense RNA and/or repetitive dipeptide repeat proteins. Recently, mouse knockouts have suggested that a loss of function of C9orf72 alone is insufficient to lead to neurodegeneration, whilst overexpression of hexanucleotide DNA is sufficient in a wide range of model systems...
March 29, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28363041/decline-of-game-birds-phasianus-colchicus-and-perdix-perdix-in-bavaria-a-survey-on-pathogenic-bacteria-parasites-pesticide-residues-and-influence-of-set-aside-land-and-maize-cultivation
#11
Anna Schmitz, Franz Kronthaler, Katrin Stein, Monika Rinder, Rüdiger Korbel
Due to a Europe-wide decline of grey partridge ( Perdix perdix ) and pheasant ( Phasianus colchicus ) populations, this study was conducted focusing on the county of Bavaria, south Germany. The aim was to assess the health status of game birds and identify possible causes of decline. For this purpose 203 pheasants and 11 partridges were examined during the 2011 hunting season. Pathologic examinations were conducted including examinations for parasites and bacteria. Due to public health significance, a screening for Salmonella sp...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28359879/a-comparison-of-fat-soluble-antioxidants-in-wild-and-farm-reared-chukar-partridges-alectoris-chukar
#12
Filiz Karadas, Anders Pape Møller, Mehmet Reşit Karageçili
This study assessed differences in antioxidant (carotenoid, retinol, retinol-ester, vitamin E and coenzyme Q10) composition of egg yolk and tissue in chukar partridges (Alectoris chukar) newly hatched from eggs of birds maintained in captivity on commercial maize-soybean based diets and birds from the wild whose diet was obtained from the natural environment. All eggs were incubated in a commercial hatchery. Day-old chicks from both groups were sacrificed and dissected for antioxidant analysis. Fat soluble antioxidant concentrations of egg yolk and tissues were determined by HPLC...
March 27, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28356369/the-independence-of-eye-movements-in-a-stomatopod-crustacean-is-task-dependent
#13
Ilse M Daly, Martin J How, Julian C Partridge, Nicholas W Roberts
Stomatopods have an extraordinary visual system, incorporating independent movement of their eyes in all three degrees of rotational freedom. In this work, we demonstrate that in the peacock mantis shrimp, Odontodactylus scyllarus, the level of ocular independence is task dependent. During gaze stabilization in the context of optokinesis, there is weak but significant correlation between the left and right eyes in the yaw degree of rotational freedom, but not in pitch and torsion. When one eye is completely occluded, the uncovered eye does not drive the covered eye during gaze stabilization...
April 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28351387/dietary-restriction-protects-from-age-associated-dna-methylation-and-induces-epigenetic-reprogramming-of-lipid-metabolism
#14
Oliver Hahn, Sebastian Grönke, Thomas M Stubbs, Gabriella Ficz, Oliver Hendrich, Felix Krueger, Simon Andrews, Qifeng Zhang, Michael J Wakelam, Andreas Beyer, Wolf Reik, Linda Partridge
BACKGROUND: Dietary restriction (DR), a reduction in food intake without malnutrition, increases most aspects of health during aging and extends lifespan in diverse species, including rodents. However, the mechanisms by which DR interacts with the aging process to improve health in old age are poorly understood. DNA methylation could play an important role in mediating the effects of DR because it is sensitive to the effects of nutrition and can affect gene expression memory over time...
March 28, 2017: Genome Biology
https://www.readbyqxmd.com/read/28346494/the-effects-of-surface-structure-mutations-in-arabidopsis-thaliana-on-the-polarization-of-reflections-from-virus-infected-leaves
#15
D J Maxwell, J C Partridge, N W Roberts, N Boonham, G D Foster
The way in which light is polarized when reflected from leaves can be affected by infection with plant viruses. This has the potential to influence viral transmission by insect vectors due to altered visual attractiveness of infected plants. The optical and topological properties of cuticular waxes and trichomes are important determinants of how light is polarized upon reflection. Changes in expression of genes involved in the formation of surface structures have also been reported following viral infection...
2017: PloS One
https://www.readbyqxmd.com/read/28339957/effects-of-caponization-and-age-on-the-histology-lipid-localization-and-fiber-diameter-in-muscles-from-greenleg-partridge-cockerels
#16
M Gesek, M Zawacka, D Murawska
The preference of modern consumers for high-quality meat has forced breeders to use native breeds to produce capons. Caponization, both chemical and surgical, leads to androgen deficiency and changes in lipid metabolism and results in the accumulation of abdominal, subcutaneous, and intramuscular lipids, which change the sensory values of the meat. The aim of this study was to histologically evaluate selected skeletal muscles from Greenleg Partridge capons and cockerels. We examined lipid localization in the muscular tissue and also assessed both fiber type and fiber diameter in the pectoral muscles...
March 3, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339925/effects-of-different-storage-time-on-hatching-results-and-some-egg-quality-characteristics-of-rock-partridge-a-graeca-management-and-production
#17
S Günhan, K Kirikçi
In this research, partridge eggs were stored during zero to 7, 8 to 14, 15 to 21, 22 to 28, 29 to 35 and 36 to 42 d, respectively. The effect of different egg storage periods on egg protein and moisture rates, mineral contents, and some egg quality and hatching characteristics were investigated. The extension of egg storage times didn't affect the external quality features like shell weight, shell thickness, and albumen rate, but it affected the yolk weight, yolk index, albumen index, and Haugh unit (P < 0...
March 3, 2017: Poultry Science
https://www.readbyqxmd.com/read/28337324/discovery-of-gbt440-an-orally-bioavailable-r-state-stabilizer-of-sickle-cell-hemoglobin
#18
Brian Metcalf, Chihyuan Chuang, Kobina Dufu, Mira P Patel, Abel Silva-Garcia, Carl Johnson, Qing Lu, James R Partridge, Larysa Patskovska, Yury Patskovsky, Steven C Almo, Matthew P Jacobson, Lan Hua, Qing Xu, Stephen L Gwaltney, Calvin Yee, Jason Harris, Bradley P Morgan, Joyce James, Donghong Xu, Athiwat Hutchaleelaha, Kumar Paulvannan, Donna Oksenberg, Zhe Li
We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions. Unlike earlier allosteric activators that bind covalently to hemoglobin in a 2:1 stoichiometry, 36 binds with a 1:1 stoichiometry. Compound 36 is orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of ∼150. This partitioning onto the target protein is anticipated to allow therapeutic concentrations to be achieved in the red blood cell at low plasma concentrations...
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28323331/survival-benefit-needed-to-undergo-chemotherapy-patient-and-physician-preferences
#19
Ines Vaz-Luis, Anne O'Neill, Karen Sepucha, Kathy D Miller, Emily Baker, Chau T Dang, Donald W Northfelt, Eric P Winer, George W Sledge, Bryan Schneider, Ann H Partridge
BACKGROUND: Published studies have suggested that most patients with early stage breast cancer are willing, for modest survival benefits, to receive 6 months of adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil, an older regimen that is used infrequently today. We examined preferences regarding the survival benefit needed to justify 6 months of a contemporary chemotherapy regimen. METHODS: The Eastern Cooperative Oncology Group Protocol 5103 was a phase 3 trial that randomized breast cancer patients to receive standard adjuvant doxorubicin, cyclophosphamide, and paclitaxel with either bevacizumab or placebo...
March 21, 2017: Cancer
https://www.readbyqxmd.com/read/28319942/right-congenital-diaphragmatic-hernias-is-there-a-correlation-between-prenatal-lung-volume-and-postnatal-survival-as-in-isolated-left-diaphragmatic-hernias
#20
Teresa Victoria, Enrico Danzer, Edward R Oliver, J Christopher Edgar, Suzanne Iyoob, Emily A Partridge, Ann M Johnson, William H Peranteau, Beverly G Coleman, Alan W Flake, Mark P Johnson, Holly H Hedrick, N Scott Adzick
OBJECTIVES: Whereas left-sided congenital diaphragmatic hernias (L-CDH) have been extensively studied and their prognostic parameters delineated, right-sided hernias (R-CDH) have not. Published results remain inconclusive. The aim of this study is to evaluate if proven prognostic indicators of postnatal survival in the fetus with L-CDH apply to the fetus with R-CDH. METHODS: Retrospective single-center study of R-CDH fetuses with available prenatal studies assessed for fetal lung volume by means of ultrasound-measured observed versus expected (O/E) lung area to head circumference (LHR) and magnetic resonance-calculated O/E total lung volume (TLV) in a 12-year time period...
March 21, 2017: Fetal Diagnosis and Therapy
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