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https://www.readbyqxmd.com/read/29329431/a-validated-method-for-the-screening-of-320-forensically-significant-compounds-in-blood-by-lc-qtof-with-simultaneous-quantification-of-selected-compounds
#1
Emma Partridge, Stephen Trobbiani, Peter Stockham, Timothy Scott, Chris Kostakis
A broad drug screening method for toxicologically significant drugs and metabolites in whole blood using liquid chromatography time-of-flight mass spectrometry (LC/QTOF) was developed and comprehensively validated. The method qualitatively screens for 320 compounds while simultaneously quantifying 39. Compounds were extracted from the blood using alkaline liquid/liquid extraction and chromatographic separation was achieved in 12 min. The QTOF was operated using positive mode electrospray ionization using data dependent acquisition...
January 10, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29320311/development-and-validation-of-a-risk-prediction-model-for-acute-kidney-injury-after-the-first-course-of-cisplatin
#2
Shveta S Motwani, Gearoid M McMahon, Benjamin D Humphreys, Ann H Partridge, Sushrut S Waikar, Gary C Curhan
Purpose Cisplatin-associated acute kidney injury (C-AKI) is common. We sought to develop and validate a predictive model for C-AKI after the first course of cisplatin. Methods Clinical and demographic data were collected on patients who received cisplatin between 2000 and 2016 at two cancer centers. C-AKI was defined as a 0.3 mg/dL rise in serum creatinine within 14 days of receiving cisplatin. Using multivariable logistic regression models with C-AKI as the primary outcome, we created a scoring model from the development cohort (DC) and tested it in the validation cohort (VC)...
January 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29302797/proactive-care-of-older-people-undergoing-surgery
#3
Judith Partridge, Magda Sbai, Jugdeep Dhesi
The number of older patients undergoing surgery is increasing due to changing demographics, surgical and anaesthetic advances and shifts in patient expectations of healthcare. The benefits of surgery in older people are well documented and include symptom control and increased life expectancy. However, older surgical patients present not only with the index pathology requiring surgery but with concurrent age related physiological decline, multimorbidity and geriatric syndromes. These additional issues increase the risk of adverse postoperative outcome, in particular of postoperative medical and functional complications...
January 4, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29300733/ten-simple-rules-for-drawing-scientific-comics
#4
EDITORIAL
Jason E McDermott, Matthew Partridge, Yana Bromberg
No abstract text is available yet for this article.
January 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29298117/association-of-cell-free-dna-tumor-fraction-and-somatic-copy-number-alterations-with-survival-in-metastatic-triple-negative-breast-cancer
#5
Daniel G Stover, Heather A Parsons, Gavin Ha, Samuel S Freeman, William T Barry, Hao Guo, Atish D Choudhury, Gregory Gydush, Sarah C Reed, Justin Rhoades, Denisse Rotem, Melissa E Hughes, Deborah A Dillon, Ann H Partridge, Nikhil Wagle, Ian E Krop, Gad Getz, Todd R Golub, J Christopher Love, Eric P Winer, Sara M Tolaney, Nancy U Lin, Viktor A Adalsteinsson
Purpose Cell-free DNA (cfDNA) offers the potential for minimally invasive genome-wide profiling of tumor alterations without tumor biopsy and may be associated with patient prognosis. Triple-negative breast cancer (TNBC) is characterized by few mutations but extensive somatic copy number alterations (SCNAs), yet little is known regarding SCNAs in metastatic TNBC. We sought to evaluate SCNAs in metastatic TNBC exclusively via cfDNA and determine if cfDNA tumor fraction is associated with overall survival in metastatic TNBC...
January 3, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29280467/potential-of-proton-therapy-to-reduce-acute-hematologic-toxicity-in-concurrent-chemoradiation-therapy-for-esophageal-cancer
#6
Samantha Warren, Christopher N Hurt, Thomas Crosby, Mike Partridge, Maria A Hawkins
PURPOSE: Radiation therapy dose escalation using a simultaneous integrated boost (SIB) is predicted to improve local tumor control in esophageal cancer; however, any increase in acute hematologic toxicity (HT) could limit the predicted improvement in patient outcomes. Proton therapy has been shown to significantly reduce HT in lung cancer patients receiving concurrent chemotherapy. Therefore, we investigated the potential of bone marrow sparing with protons for esophageal tumors. METHODS AND MATERIALS: Twenty-one patients with mid-esophageal cancer who had undergone conformal radiation therapy (3D50) were selected...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29246153/referral-patterns-delays-and-equity-in-access-to-advanced-paediatric-emergency-care-in-vietnam
#7
Emily Treleaven, Toan Ngoc Pham, Duy Ngoc Le, Trevor N Brooks, Hai Thanh Le, J Colin Partridge
BACKGROUND: Quality emergency care is a critical component of a well-functioning health system. However, severely ill children often face barriers to timely, appropriate care in less-developed health systems. Such barriers disproportionately affect poorer children, and may be particularly acute when children seek advanced emergency care. We examine predictors of increased acuity and patient outcomes at a tertiary paediatric emergency department to identify barriers to advanced emergency care among children...
December 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29238073/stage-dependent-therapeutic-efficacy-in-pi3k-mtor-driven-squamous-cell-carcinoma-of-the-skin
#8
Charbel Darido, Smitha R Georgy, Carleen Cullinane, Darren D Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R Carpinelli, Sebastian Dworkin, Richard B Pearson, Stephen M Jane
Cutaneous squamous cell carcinoma (SCC) is a recurrent cancer that is prevalent in predisposed subjects such as immunosuppressed patients and patients being treated for other malignancies. Model systems to trial therapies at different stages of SCC development are lacking, therefore precluding efficient therapeutic interventions. Here, we have disrupted the expression of the tumor suppressor GRHL3 to induce loss of PTEN and activation of the PI3K/mTOR signaling pathway in mice and human skin, promoting aggressive SCC development...
December 13, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29226997/participation-and-interest-in-support-services-among-family-caregivers-of-older-adults-with-cancer
#9
J Nicholas Dionne-Odom, Allison J Applebaum, Katherine Ornstein, Andres Azuero, Paula P Warren, Richard A Taylor, Gabrielle Rocque, Elizabeth Kvale, Wendy Demark-Wahnefried, Maria Pisu, Edward Partridge, Michelle Y Martin, Marie Bakitas
OBJECTIVE: To describe distressed and underprepared family caregiver's use of and interest in formal support services (e.g., professional counseling, education, organizational assistance). METHODS: Cross-sectional mail survey conducted in communities of eight cancer centers in Tennessee, Alabama, and Florida (response rate: 42%). Family caregivers of Medicare beneficiaries with pancreatic, lung, brain, ovarian, head and neck, hematologic, and stage IV cancers reported support service use and completed validated measures of depression, anxiety, burden, preparedness, and health...
December 11, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29223747/an-automated-high-throughput-system-for-phenotypic-screening-of-chemical-libraries-on-c-elegans-and-parasitic-nematodes
#10
Frederick A Partridge, Anwen E Brown, Steven D Buckingham, Nicky J Willis, Graham M Wynne, Ruth Forman, Kathryn J Else, Alison A Morrison, Jacqueline B Matthews, Angela J Russell, David A Lomas, David B Sattelle
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global threat. We have developed an INVertebrate Automated Phenotyping Platform (INVAPP) for high-throughput, plate-based chemical screening, and an algorithm (Paragon) which allows screening for compounds that have an effect on motility and development of parasitic worms...
December 2, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29218742/prevalence-of-foot-disorders-in-captive-sardinian-partridges-alectoris-barbara-barbara-bonnaterre-1790-as-useful-indicators-of-fitness-to-natural-environment
#11
M G Cappai, A Abd El-Wahab, G Arru, M Muzzeddu, W Pinna
Foot health represents an issue in wild avifauna breeding practices. In particular, prevalence of digital ulceration (DU) and foot pad dermatitis (FPD) are valid indicators of welfare in wildlife conservation centres and may be interpreted as to fitness for bird's reintroduction into the wild. This study meant to test the effects of raising practices on foot pad health in captive Sardinian partridges (Alectoris barbara barbara Bonnaterre, 1790) reared for biodiversity conservation, to assess welfare and fitness to reintroduction into nature...
December 8, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29206499/expert-judgment-based-multicriteria-decision-models-to-assess-the-risk-of-pesticides-on-reproduction-failures-of-grey-partridge
#12
J Devillers, H Devillers, E Bro, F Millot
A suite of models is proposed for estimating the risk of pesticides against the grey partridge (Perdix perdix) and their clutches. Radio-tracked data of females, description and location of the clutches, and data on the pesticide treatments during the laying periods of the partridges were used as basic information. Quantitative structure-activity relationship (QSAR) and quantitative structure-property relationship (QSPR) modelling allowed us to characterize the pesticides by their 1-octanol/water partition coefficient (log P), vapour pressure, primary and ultimate biodegradation potential, acute toxicity (LD50) on P...
November 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29205064/2017-white-paper-on-recent-issues-in-bioanalysis-a-global-perspective-on-immunogenicity-guidelines-biomarker-assay-performance-part-3-lba-immunogenicity-biomarkers-and-pk-assays
#13
Shalini Gupta, Susan Richards, Lakshmi Amaravadi, Steven Piccoli, Binodh Desilva, Renuka Pillutla, Lauren Stevenson, Devangi Mehta, Montserrat Carrasco-Triguero, Robert Neely, Michael Partridge, Roland F Staack, Xuemei Zhao, Boris Gorovits, Gerry Kolaitis, Giane Sumner, Kay-Gunnar Stubenrauch, Linglong Zou, Shashi Amur, Chris Beaver, Isabella Berger, Flora Berisha, Herbert Birnboeck, Joe Bower, Seongeun Julia Cho, Isabelle Cludts, Laurent Cocea, Lorella Di Donato, Saloumeh Fischer, Stephanie Fraser, Fabio Garofolo, Sam Haidar, Jonathan Haulenbeek, Charles Hottenstein, Jenny Hu, Akiko Ishii-Watabe, Rafiq Islam, Darshana Jani, John Kadavil, John Kamerud, Daniel Kramer, Pekka Kurki, Stephen MacMannis, Jim McNally, Ashley Mullan, Apollon Papadimitriou, João Pedras-Vasconcelos, Soma Ray, Afshin Safavi, Yoshiro Saito, Natasha Savoie, Marianne Scheel Fjording, Kara Scheibner, John Smeraglia, An Song, Bruce Stouffer, Nilufer Tampal, Barry van der Strate, Thorsten Verch, Jan Welink, Yuanxin Xu, Tong-Yuan Yang, Lilian Yengi, Jianing Zeng, Yan Zhang, Yanhua Zhang, Stephen Zoog
The 2017 11th Workshop on Recent Issues in Bioanalysis took place in Los Angeles/Universal City, California, on 3-7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, week-long event - a full immersion week of bioanalysis, biomarkers and immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small- and large-molecule analysis involving LC-MS, hybrid ligand-binding assay (LBA)/LC-MS and LBA approaches...
December 2017: Bioanalysis
https://www.readbyqxmd.com/read/29184155/isolation-and-molecular-characterization-of-prevalent-fowl-adenovirus-strains-in-southwestern-china-during-2015-2016-for-the-development-of-a-control-strategy
#14
Jing Xia, Ke-Chang Yao, Yue-Yue Liu, Guo-Jin You, Su-Yun Li, Ping Liu, Qin Zhao, Yi-Ping Wen Rui Wu, Xiao-Bo Huang, San-Jie Cao, Xin-Feng Han, Yong Huang
Fowl adenovirus (FAdV) has caused significant losses in chicken flocks throughout China in recent years. However, the current understanding of the genetic and pathogenic characteristics of the FAdV epidemic in southwestern China remains poorly understood. In this study, a total of 22 strains were isolated from liver samples of diseased chickens from farms in southwestern China. Phylogenetic analysis based on the hexon loop-1 gene showed that the 22 isolates were clustered into four distinct serotypes: FAdV serotype 4 (FAdV-4) (86...
November 29, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29181901/bird-diversity-in-northern-myanmar-and-conservation-implications
#15
Ming-Xia Zhang, Myint Kyaw, Guo-Gang Li, Jiang-Bo Zhao, Xiang-Le Zeng, Kyaw Swa, Rui-Chang Quan
We conducted four bird biodiversity surveys in the Putao area of northern Myanmar from 2015 to 2017. Combined with anecdotal information collected between 2012 and 2015, we recorded 319 bird species, including two species (Arborophila mandellii and Lanius sphenocercus) previously unrecorded in Myanmar. Bulbuls (Pycnonotidae), babblers (Timaliidae), pigeons and doves (Columbidae), and pheasants and partridges (Phasianidae) were the most abundant groups of birds recorded. Species richness below 1 500 m a. s. l...
September 18, 2017: Zoological Research
https://www.readbyqxmd.com/read/29178894/changes-in-overall-ventricular-myocardial-architecture-in-the-setting-of-a-porcine-animal-model-of-right-ventricular-dilation
#16
Peter Agger, Christine Ilkjær, Christoffer Laustsen, Morten Smerup, Jesper R Frandsen, Steffen Ringgaard, Michael Pedersen, John B Partridge, Robert H Anderson, Vibeke Hjortdal
BACKGROUND: Chronic pulmonary regurgitation often leads to myocardial dysfunction and heart failure. It is not fully known why secondary hypertrophy cannot fully protect against the increase in wall stress brought about by the increased end-diastolic volume in ventricular dilation. It has been assumed that mural architecture is not deranged in this situation, but we hypothesised that there might be a change in the pattern of orientation of the aggregations of cardiomyocytes, which would contribute to contractile impairment...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29178616/diffusion-weighted-mri-characteristics-associated-with-prognostic-pathological-factors-and-recurrence-risk-in-invasive-er-her2-breast-cancers
#17
Nita Amornsiripanitch, Vicky T Nguyen, Habib Rahbar, Daniel S Hippe, Vijayakrishna K Gadi, Mara H Rendi, Savannah C Partridge
BACKGROUND: Hormone receptor-positive breast cancer is the most common subtype; better tools to identify which patients in this group would derive clear benefit from chemotherapy are needed. PURPOSE: To evaluate the prognostic potential of diffusion-weighted MRI (DWI) by investigating associations with pathologic biomarkers and a genomic assay for 10-year recurrence risk. STUDY TYPE: Retrospective. SUBJECTS: In all, 107 consecutive patients (from 2/2010 to 1/2013) with estrogen receptor (ER)-positive/HER2neu-negative invasive breast cancer who had the 21-gene recurrence score (RS) test (Oncotype DX, Genomic Health)...
November 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29178423/effectiveness-of-lifestyle-interventions-for-preventing-harmful-weight-gain-among-young-adults-from-lower-socioeconomic-status-and-ethnically-diverse-backgrounds-a-systematic-review
#18
REVIEW
N Hayba, S R Partridge, M M Nour, A Grech, M Allman Farinelli
The incidence of overweight and obesity are increasing with each successive generation of young adults. Associated co-morbidities will emerge at an earlier age unless weight gain is prevented. Evidence has demonstrated young adults (aged 18-35 years) from low socioeconomic and ethnically diverse backgrounds are at greater risk of overweight or obesity, yet it is unclear how to effectively intervene in this population. This systematic review aimed to assess the effectiveness of lifestyle interventions conducted in this population...
November 26, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29170567/predicting-ecological-responses-in-a-changing-ocean-the-effects-of-future-climate-uncertainty
#19
REVIEW
Jennifer J Freer, Julian C Partridge, Geraint A Tarling, Martin A Collins, Martin J Genner
Predicting how species will respond to climate change is a growing field in marine ecology, yet knowledge of how to incorporate the uncertainty from future climate data into these predictions remains a significant challenge. To help overcome it, this review separates climate uncertainty into its three components (scenario uncertainty, model uncertainty, and internal model variability) and identifies four criteria that constitute a thorough interpretation of an ecological response to climate change in relation to these parts (awareness, access, incorporation, communication)...
2018: Marine Biology
https://www.readbyqxmd.com/read/29127344/catabolic-effects-of-human-pth-1-34-on-bone-requirement-of-monocyte-chemoattractant-protein-1-in-murine-model-of-hyperparathyroidism
#20
Jawed A Siddiqui, Joshua Johnson, Carole Le Henaff, Claudine L Bitel, Joseph A Tamasi, Nicola C Partridge
The bone catabolic actions of parathyroid hormone (PTH) are seen in patients with hyperparathyroidism, or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH's anabolic effects on bone. To determine its role in PTH's catabolic effects, we continuously infused female wild-type (WT) and MCP-1(-/-) mice with hPTH or vehicle. Microcomputed tomography (µCT) analysis of cortical bone showed that hPTH-infusion induced significant bone loss in WT mice...
November 10, 2017: Scientific Reports
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