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https://www.readbyqxmd.com/read/28534519/two-forms-of-death-in-ageing-caenorhabditis-elegans
#1
Yuan Zhao, Ann F Gilliat, Matthias Ziehm, Mark Turmaine, Hongyuan Wang, Marina Ezcurra, Chenhao Yang, George Phillips, David McBay, William B Zhang, Linda Partridge, Zachary Pincus, David Gems
Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting pathologies in Caenorhabditis elegans with a necropsy analysis of worms that have died of old age. Our results imply the presence of multiple causes of death. Specifically, we identify two classes of corpse: early deaths with a swollen pharynx (which we call 'P deaths'), and later deaths with an atrophied pharynx (termed 'p deaths'). The effects of interventions on lifespan can be broken down into changes in the frequency and/or timing of either form of death...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28534492/corrigendum-an-extra-uterine-system-to-physiologically-support-the-extreme-premature-lamb
#2
Emily A Partridge, Marcus G Davey, Matthew A Hornick, Patrick E McGovern, Ali Y Mejaddam, Jesse D Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C Caskey, Theodore R Weiland, Jiancheng Han, Alexander J Schupper, James T Connelly, Kevin C Dysart, Jack Rychik, Holly L Hedrick, William H Peranteau, Alan W Flake
This corrects the article DOI: 10.1038/ncomms15112.
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28533206/myostatin-like-proteins-regulate-synaptic-function-and-neuronal-morphology
#3
Hrvoje Augustin, Kieran McGourty, Joern R Steinert, Helena M Cochemé, Jennifer Adcott, Melissa Cabecinha, Alec Vincent, Els F Halff, Josef T Kittler, Emmanuel Boucrot, Linda Partridge
Growth factors of the TGF-β superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass. However, expression of both Myostatin and its cognate receptors in other tissues, including brain and peripheral nerves, suggests a potential wider biological role. Here, we show that Myoglianin (MYO), the Drosophila homolog of Myostatin and GDF11, regulates not only body weight and muscle size, but also inhibits neuromuscular synapse strength and composition in a Smad2-dependent manner...
May 22, 2017: Development
https://www.readbyqxmd.com/read/28529232/backwards-medicine-female-atavism-whiteness-and-the-medical-profession-in-the-pineal-eye
#4
Deanna Gross Scherger
This article examines atavism as a theory of racial science in the nineteenth-century United States that illuminates how the developing medical profession reinforced racial, class, and gender hierarchies to gain cultural authority. I use John S. Partridge's "The Pineal Eye," a little-known short story published in San Francisco's The Wave in 1894, as a case study that reveals how atavism was conceived as pathology within the purview of medical study. Partridge intertwines established atavistic discourse that asserted the Anglo-Saxon female body as paradoxically modern in terms of racial identity and primitive in terms of sex with scientific experimentation and male medical authority, resulting in evolutionary regression...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28523779/arylative-intramolecular-allylation-of-ketones-with-1-3-enynes-enabled-by-catalytic-alkenyl-to-allyl-1-4-rhodium-i-migration
#5
Benjamin M Partridge, Michael Callingham, William Lewis, Hon Wai Lam
Alkenyl-to-allyl 1,4-rhodium(I) migration enables the generation of nucleophilic allylrhodium(I) species by remote C-H activation. This new mode of reactivity was employed in the diastereoselective reaction of arylboron reagents with substrates containing a 1,3-enyne tethered to a ketone, to give products containing three contiguous stereocenters. The products can be obtained in high enantioselectivities using a chiral sulfur-alkene ligand.
May 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28512472/pulsed-electromagnetic-field-regulates-microrna-21-expression-to-activate-tgf-%C3%AE-signaling-in-human-bone-marrow-stromal-cells-to-enhance-osteoblast-differentiation
#6
Nagarajan Selvamurugan, Zhiming He, Daniel Rifkin, Branka Dabovic, Nicola C Partridge
Pulsed electromagnetic fields (PEMFs) have been documented to promote bone fracture healing in nonunions and increase lumbar spinal fusion rates. However, the molecular mechanisms by which PEMF stimulates differentiation of human bone marrow stromal cells (hBMSCs) into osteoblasts are not well understood. In this study the PEMF effects on hBMSCs were studied by microarray analysis. PEMF stimulation of hBMSCs' cell numbers mainly affected genes of cell cycle regulation, cell structure, and growth receptors or kinase pathways...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28508177/standing-postural-control-in-individuals-with-autism-spectrum-disorder-systematic-review-and-meta-analysis
#7
Yi Huey Lim, Katie Partridge, Sonya Girdler, Susan L Morris
Impairments in postural control affect the development of motor and social skills in individuals with autism spectrum disorder (ASD). This review compared the effect of different sensory conditions on static standing postural control between ASD and neurotypical individuals. Results from 19 studies indicated a large difference in postural control between groups across all sensory conditions. This review revealed sensorimotor and multiple sensory processing deficits in ASD. The tendency for individuals with ASD to be more susceptible to postural instability with use of visual information compared with somatosensory information suggests perinatal alterations in sensory development...
May 15, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28504889/genetic-characterization-of-vana-enterococcus-faecium-isolates-from-wild-red-legged-partridges-in-portugal
#8
Vanessa Silva, Gilberto Igrejas, Isabel Carvalho, Fernando Peixoto, Lucas Cardoso, José Eduardo Pereira, Rosa Del Campo, Patricia Poeta
Vancomycin-resistant enterococci (VRE) have been detected in wild animals representing a public health concern. The red-legged partridge (Alectoris rufa) is a common game bird and its meat is consumed in several countries, including Portugal. Three hundred five fecal samples of red-legged partridge from the north of Portugal were screened for VRE. Samples were cultured on Slanetz-Bartley agar supplemented with vancomycin (4 mg/L) and six vanA-Enterococcus faecium were recovered. Isolates were tested for antibiotic resistance and virulence genes...
May 15, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28488898/bridging-immunogenicity-assays-for-igg4-therapeutics-mitigating-interference-from-fc-fc-interactions
#9
Michael A Partridge, Uma Vijayam, Elif Kabuloglu Karayusuf, Enoch Shum, Thanoja Sirimanne, John Garlits, Jihua Chen, Albert Torri, Giane Sumner
AIM: A bridging immunogenicity assay for a human IgG4 mAb therapeutic was transferred to an automation system to increase throughput. However, background signal increased five- to six-fold during the 6- to 8-h run. RESULTS: Noncovalent Fc contacts formed between labeled IgG4 drugs in reagent solutions stored during the automation run. This generated substantial background signal, reducing assay sensitivity by approximately sixfold. Fc interactions also significantly impacted the confirmation assay...
May 10, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28472736/growth-performance-blood-profiles-and-carcass-traits-of-barbary-partridge-alectoris-barbara-fed-two-different-insect-larvae-meals-tenebrio-molitor-and-hermetia-illucens
#10
Rosa Loponte, Sandra Nizza, Fulvia Bovera, Nicola De Riu, Katerina Fliegerova, Pietro Lombardi, Giuseppe Vassalotti, Vincenzo Mastellone, Antonino Nizza, Giuseppe Moniello
To investigate the effect of two insect meals (from Hermetia illucens, HI and Tenebrio molitor, TM larvae) on productive performance and blood profiles of Barbary partridge, ninety, seven days old partridges were divided into 5 groups (6 replicates, 3 partridges/replicate). Up to 64d, the groups fed 5 isoproteic and isoenergetic diets: the control fed a corn-soybean meal diet (SBM group); in TM25 and TM50 groups the 25 and 50% of SBM proteins were substituted by the protein from TM, respectively; in HI25 and HI50 groups the 25 and 50% of SBM were substituted by the protein from HI, respectively...
April 26, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28469029/how-do-seemingly-non-vagile-clades-accomplish-trans-marine-dispersal-trait-and-dispersal-evolution-in-the-landfowl-aves-galliformes
#11
Peter A Hosner, Joseph A Tobias, Edward L Braun, Rebecca T Kimball
Dispersal ability is a key factor in determining insular distributions and island community composition, yet non-vagile terrestrial organisms widely occur on oceanic islands. The landfowl (pheasants, partridges, grouse, turkeys, quails and relatives) are generally poor dispersers, but the Old World quail (Coturnix) are a notable exception. These birds evolved small body sizes and high-aspect-ratio wing shapes, and hence are capable of trans-continental migrations and trans-oceanic colonization. Two monotypic partridge genera, Margaroperdix of Madagascar and Anurophasis of alpine New Guinea, may represent additional examples of trans-marine dispersal in landfowl, but their body size and wing shape are typical of poorly dispersive continental species...
May 17, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28467937/matching-dietary-amino-acid-balance-to-the-in-silico-translated-exome-optimizes-growth-and-reproduction-without-cost-to-lifespan
#12
Matthew D W Piper, George A Soultoukis, Eric Blanc, Andrea Mesaros, Samantha L Herbert, Paula Juricic, Xiaoli He, Ilian Atanassov, Hanna Salmonowicz, Mingyao Yang, Stephen J Simpson, Carlos Ribeiro, Linda Partridge
No abstract text is available yet for this article.
May 2, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28455971/2nd-interventions-in-aging-conference
#13
Brian K Kennedy, Linda Partridge
No abstract text is available yet for this article.
April 2017: Aging
https://www.readbyqxmd.com/read/28446614/constraining-the-instantaneous-aerosol-influence-on-cloud-albedo
#14
Edward Gryspeerdt, Johannes Quaas, Sylvaine Ferrachat, Andrew Gettelman, Steven Ghan, Ulrike Lohmann, Hugh Morrison, David Neubauer, Daniel G Partridge, Philip Stier, Toshihiko Takemura, Hailong Wang, Minghuai Wang, Kai Zhang
Much of the uncertainty in estimates of the anthropogenic forcing of climate change comes from uncertainties in the instantaneous effect of aerosols on cloud albedo, known as the Twomey effect or the radiative forcing from aerosol-cloud interactions (RFaci), a component of the total or effective radiative forcing. Because aerosols serving as cloud condensation nuclei can have a strong influence on the cloud droplet number concentration (Nd ), previous studies have used the sensitivity of the Nd to aerosol properties as a constraint on the strength of the RFaci...
May 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28440792/an-extra-uterine-system-to-physiologically-support-the-extreme-premature-lamb
#15
Emily A Partridge, Marcus G Davey, Matthew A Hornick, Patrick E McGovern, Ali Y Mejaddam, Jesse D Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C Caskey, Theodore R Weiland, Jiancheng Han, Alexander J Schupper, James T Connelly, Kevin C Dysart, Jack Rychik, Holly L Hedrick, William H Peranteau, Alan W Flake
In the developed world, extreme prematurity is the leading cause of neonatal mortality and morbidity due to a combination of organ immaturity and iatrogenic injury. Until now, efforts to extend gestation using extracorporeal systems have achieved limited success. Here we report the development of a system that incorporates a pumpless oxygenator circuit connected to the fetus of a lamb via an umbilical cord interface that is maintained within a closed 'amniotic fluid' circuit that closely reproduces the environment of the womb...
April 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28424660/ccl2-monocyte-chemoattractant-protein-1-and-parathyroid-hormone-action-on-bone
#16
REVIEW
Jawed Akhtar Siddiqui, Nicola C Partridge
Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coupled receptors. Two well-described chemokine families (CXC and CC) are known to regulate the localization and trafficking of immune cells in cases of injury, infection, and tumors. Monocyte chemoattractant protein 1 (MCP-1/CCL2) is one of the important chemokines from the CC family that controls migration and infiltration of monocytes/macrophages during inflammation...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28420437/bidirectional-nucleolar-dysfunction-in-c9orf72-frontotemporal-lobar-degeneration
#17
Sarah Mizielinska, Charlotte E Ridler, Rubika Balendra, Annora Thoeng, Nathan S Woodling, Friedrich A Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge, Adrian M Isaacs
An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and dipeptide repeat (DPR) proteins, generated by repeat-associated non-ATG translation. The arginine-rich DPR proteins poly(glycine-arginine or GR) and poly(proline-arginine or PR) are potently neurotoxic and can localise to the nucleolus when expressed in cells, resulting in enlarged nucleoli with disrupted functionality...
April 18, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28419442/characterization-of-runx2-phosphorylation-sites-required-for-tgf-%C3%AE-1-mediated-stimulation-of-matrix-metalloproteinase-13-expression-in-osteoblastic-cells
#18
Balasubramanian Arumugam, Mariappanadar Vairamani, Nicola C Partridge, Nagarajan Selvamurugan
Transforming growth factor-beta1 (TGF-β1), a highly abundant growth factor in skeletal tissues, stimulates matrix metalloproteinase-13 (MMP-13) expression in osteoblastic cells. MMP-13 plays a critical role in bone remodeling. Runx2, a bone transcription factor, is required for TGF-β1-mediated stimulation of MMP-13 expression in osteoblastic cells. In this study, the molecular mechanism responsible for TGF-β1-stimulation of MMP-13 expression via Runx2 in osteoblastic cells was elucidated. TGF-β1 stimulated the phosphorylation of Runx2 at serine amino acids, and ERK inhibition blocked this effect in rat (UMR106-01) and human (MG-63) osteoblastic cells...
April 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28408620/oncofertility-fertile-ground-for-conflict-between-patient-autonomy-and-medical-values
#19
Sarah K Walsh, Elizabeth S Ginsburg, Lisa Soleymani Lehmann, Ann H Partridge
Oncofertility is a unique, multidisciplinary field that serves to bridge the gap between available fertility resources and the special reproductive needs of cancer patients. Oncofertility is a growing field due to the increasing number of survivors, development of new oncologic therapies, extension of duration of therapies, and development and refinement of reproductive therapies. While the technologies and demand for services expand, clinicians need to be appropriately prepared for dealing with various clinical scenarios that may require ethical deliberation...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28408487/tspan2-a-tetraspanin-protein-involved-in-oligodendrogenesis-and-cancer-metastasis
#20
REVIEW
Ibrahim H Yaseen, Peter N Monk, Lynda J Partridge
Tetraspanin 2 (Tspan2) is one of the less well-characterised members of the tetraspanin superfamily, and its precise function in different human tissue types remains to be explored. Initial studies have highlighted its possible association in neuroinflammation and carcinogenesis. In the central nervous system, Tspan2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility and invasion functions...
April 15, 2017: Biochemical Society Transactions
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