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Thomas Partridge, Annalisa Nicastri, Anna E Kliszczak, Louis-Marie Yindom, Benedikt M Kessler, Nicola Ternette, Persephone Borrow
Elucidation of novel peptides presented by human leukocyte antigen (HLA) class I alleles by immunopeptidomics constitutes a powerful approach that can inform the rational design of CD8+ T cell inducing vaccines to control infection with pathogens such as human immunodeficiency virus type 1 (HIV-1) or to combat tumors. Recent advances in the sensitivity of liquid chromatography tandem mass spectrometry instrumentation have facilitated the discovery of thousands of natural HLA-restricted peptides in a single measurement...
2018: Frontiers in Immunology
James H Catterson, Mobina Khericha, Miranda C Dyson, Alec J Vincent, Rebecca Callard, Steven M Haveron, Arjunan Rajasingam, Mumtaz Ahmad, Linda Partridge
Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees of IF and found that just one month of a 2-day fed:5-day fasted IF regime at the beginning of adulthood was sufficient to extend lifespan. This long-lasting, beneficial effect of early IF was not due to reduced fecundity. Starvation resistance and resistance to oxidative and xenobiotic stress were increased after IF...
May 8, 2018: Current Biology: CB
Rachel E Pain, Ruth G Shaw, Seema N Sheth
PREMISE OF THE STUDY: Mutualistic relationships with microbes may aid plants in overcoming environmental stressors and increase the range of abiotic environments where plants can persist. Rhizobia, nitrogen-fixing bacteria associated with legumes, often confer fitness benefits to their host plants by increasing access to nitrogen in nitrogen-limited soils, but effects of rhizobia on host fitness under other stresses, such as drought, remain unclear. METHODS: In this greenhouse study, we varied the application of rhizobia (Bradyrhizobium sp...
May 16, 2018: American Journal of Botany
Nádia Kienen, Lorna Bittencourt, Sandra M Pelloso, Marcia E Consolaro, Philip E Castle, Edward E Partridge, Nia R Silva, Isabel C Scarinci
BACKGROUND: Despite the availability of cervical cancer screening programs in Brazil, some women do not participate in these programs owing to structural and/or interpersonal/intrapersonal barriers, resulting in high cervical cancer incidence and mortality. Integrating community health workers (CHWs) into the delivery of cervical cancer screening interventions is potentially a feasible strategy to address these barriers. OBJECTIVES: This study aimed to implement and evaluate a CHW training to deliver a brief intervention to promote cervical cancer screening among underscreened and unscreened women in Brazil...
2018: Progress in Community Health Partnerships: Research, Education, and Action
Alex R Campbell, Alexander J Rodriguez, David M Larson, Craig E Strauss, Ross F Garberich, Matthew F Partridge, Timothy D Henry, Scott W Sharkey
OBJECTIVE: In patients with suspected acute coronary syndrome (ACS), troponin testing is effective for diagnosis and prognosis. Troponin testing has now expanded to include patients without suspected ACS. This nonselective troponin testing has unknown consequences for resource utilization and outcome. Therefore, we examined selective versus nonselective troponin testing with respect to patient characteristics, resource utilization, and outcome. METHODS: This retrospective 1-year study included all patients with troponin testing at a U...
May 2018: American Heart Journal
Pengfei Duan, Ria Toumpaniari, Simon Partridge, Mark A Birch, Paul G Genever, Steve J Bull, Kenneth W Dalgarno, Andrew W McCaskie, Jinju Chen
This paper presents an investigation of how different culture media (i.e. basal and osteogenic media) affect the nanomechanical properties and microstructure of the mineralized matrix produced by the human mesenchymal stem cell line Y201, from both an experimental and theoretical approach. A bone nodule (i.e. mineralized matrix) cultured from basal medium shows a more anisotropic microstructure compared to its counterpart cultured from an osteogenic medium. As confirmed by finite element simulations, this anisotropic microstructure explains the bimodal distribution of the corresponding mechanical properties very well...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Cristina Cano-Gómez, Francisco Llorente, Elisa Pérez-Ramírez, Ramón C Soriguer, Mathieu Sarasa, Miguel Ángel Jiménez-Clavero
Bagaza virus (BAGV; synonymous to Israel turkey meningoencephalomyelitis virus, ITV) is a relevant arthropod-borne epornitic flavivirus. In its first emergence in Europe (southern Spain, 2010) BAGV caused an outbreak, severely affecting red-legged partridges and common pheasants. The effects (pathogenicity, role as reservoir host) of BAGV in other European phasianids are unknown. To fill this gap, grey partridges were experimentally infected with BAGV. The clinical course of the disease was severe, with neurological signs, significant weight loss and 40% mortality...
May 9, 2018: Veterinary Research
G P Tiley, R T Kimball, E L Braun, J G Burleigh
BACKGROUND: Recent large-scale whole genome sequencing efforts in birds have elucidated broad patterns of avian phylogeny and genome evolution. However, despite the great interest in economically important phasianids like Gallus gallus (Red Junglefowl, the progenitor of the chicken), we know little about the genomes of closely related species. Gallus gallus is highly sexually dichromatic and polygynous, but its sister genus, Bambusicola, is smaller, sexually monomorphic, and monogamous with biparental care...
May 8, 2018: BMC Genomics
Ronald Rosenberg, Nicole P Lindsey, Marc Fischer, Christopher J Gregory, Alison F Hinckley, Paul S Mead, Gabriela Paz-Bailey, Stephen H Waterman, Naomi A Drexler, Gilbert J Kersh, Holley Hooks, Susanna K Partridge, Susanna N Visser, Charles B Beard, Lyle R Petersen
INTRODUCTION: Vectorborne diseases are major causes of death and illness worldwide. In the United States, the most common vectorborne pathogens are transmitted by ticks or mosquitoes, including those causing Lyme disease; Rocky Mountain spotted fever; and West Nile, dengue, and Zika virus diseases. This report examines trends in occurrence of nationally reportable vectorborne diseases during 2004-2016. METHODS: Data reported to the National Notifiable Diseases Surveillance System for 16 notifiable vectorborne diseases during 2004-2016 were analyzed; findings were tabulated by disease, vector type, location, and year...
May 4, 2018: MMWR. Morbidity and Mortality Weekly Report
Ilse M Daly, Martin J How, Julian C Partridge, Nicholas W Roberts
Almost all animals, regardless of the anatomy of the eyes, require some level of gaze stabilization in order to see the world clearly and without blur. For the mantis shrimp, achieving gaze stabilization is unusually challenging as their eyes have an unprecedented scope for movement in all three rotational degrees of freedom: yaw, pitch and torsion. We demonstrate that the species Odontodactylus scyllarus performs stereotypical gaze stabilization in the yaw degree of rotational freedom, which is accompanied by simultaneous changes in the pitch and torsion rotation of the eye...
May 16, 2018: Proceedings. Biological Sciences
Matteo Lambertini, Halle C F Moore, Robert C F Leonard, Sibylle Loibl, Pamela Munster, Marco Bruzzone, Luca Boni, Joseph M Unger, Richard A Anderson, Keyur Mehta, Susan Minton, Francesca Poggio, Kathy S Albain, Douglas J A Adamson, Bernd Gerber, Amy Cripps, Gianfilippo Bertelli, Sabine Seiler, Marcello Ceppi, Ann H Partridge, Lucia Del Mastro
Purpose The role of temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy as a strategy to preserve ovarian function and fertility in premenopausal women remains controversial. This systematic review and meta-analysis using individual patient-level data was conducted to better assess the efficacy and safety of this strategy in patients with early breast cancer. Methods The trials in which premenopausal women with early breast cancer were randomly assigned to receive (neo)adjuvant chemotherapy alone or with concurrent GnRHa were eligible for inclusion...
May 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
John R Scheel, Eunhee Kim, Savannah C Partridge, Constance D Lehman, Mark A Rosen, Wanda K Bernreuter, Etta D Pisano, Helga S Marques, Elizabeth A Morris, Paul T Weatherall, Sandra M Polin, Gillian M Newstead, Laura J Esserman, Mitchell D Schnall, Nola M Hylton
OBJECTIVE: The objective of our study was to determine the accuracy of preoperative measurements for detecting pathologic complete response (CR) and assessing residual disease after neoadjuvant chemotherapy (NACT) in patients with locally advanced breast cancer. SUBJECTS AND METHODS: The American College of Radiology Imaging Network 6657 Trial prospectively enrolled women with ≥ 3 cm invasive breast cancer receiving NACT. Preoperative measurements of residual disease included longest diameter by mammography, MRI, and clinical examination and functional volume on MRI...
April 30, 2018: AJR. American Journal of Roentgenology
Zoe M Matthews, Patrick J B Edwards, Ariane Kahnt, Mark G Collett, Jonathan C Marshall, Ashton C Partridge, Scott J Harrison, Karl Fraser, Mingshu Cao, Peter J Derrick
Introduction: Photosensitization is a common clinical sign in cows suffering from liver damage caused by the mycotoxin sporidesmin. This disease, called facial eczema (FE), is of major importance in New Zealand. Current techniques for diagnosing animals with subclinical sporidesmin-induced liver damage (i.e. without photosensitization) are nonspecific. In addition, little is known of the mechanisms involved in sporidesmin resistance, nor the early effects seen following low-dose sporidesmin intoxication...
2018: Metabolomics: Official Journal of the Metabolomic Society
Wei Luo, Jiguo Xu, Zhenhui Li, Haiping Xu, Shudai Lin, Jiaying Wang, Hongjia Ouyang, Qinghua Nie, Xiquan Zhang
BACKGROUND/AIMS: Earlobe color is a typical external trait in chicken. There are some previous studies showing that the chicken white/red earlobe color is a polygenic and sex-linked trait in some breeds, but its molecular genetic and histological mechanisms still remain unclear. METHODS: We herein utilized histological section, genome-wide association study (GWAS) and RNA-seq, further to investigate the potential histological and molecular genetic mechanisms of white/red earlobe formation in Qiangyuan Partridge chicken (QYP)...
April 25, 2018: Cellular Physiology and Biochemistry
Anqiang Lai, Guozhong Dong, Daijun Song, Tan Yang, Xiaolong Zhang
BACKGROUND: Coccidiosis is a prevalent problem in chicken production. Dietary addition of coccidiostats and vaccination are two approaches used to suppress coccidia in the practical production. Methionine (Met) is usually the first limiting amino acid that plays important roles in protein metabolism and immune functions in chickens. The present study is aimed to investigate whether increasing dietary Met levels will improve the anticoccidial effects in broilers medicated or vaccinated against coccidia under Eimeria (E...
April 25, 2018: BMC Veterinary Research
Nicola J Roberts, Mike Ward, Irem Patel, Janelle Yorke, Martyn R Partridge
The concept of integrated care has been advocated for many years to address some of the challenges faced by the NHS. This report examines the experiences of respiratory healthcare specialists working in an integrated role. Twelve qualitative telephone interviews were undertaken with a range of integrated respiratory specialists and their teams working in both hospitals and the community. A descriptive and thematic approach to data analysis was adopted. Participants were very enthusiastic about their roles and saw themselves as ambassadors for this new way of working...
March 2018: London Journal of Primary Care
Philip D Poorvu, Ann H Partridge
No abstract text is available yet for this article.
April 15, 2018: Oncology (Williston Park, NY)
Cheng Tan, Jinhwan Lee, Soon-Gil Jung, Tuson Park, Sultan Albarakati, James Partridge, Matthew R Field, Dougal G McCulloch, Lan Wang, Changgu Lee
Two-dimensional van der Waals materials have demonstrated fascinating optical and electrical characteristics. However, reports on magnetic properties and spintronic applications of van der Waals materials are scarce by comparison. Here, we report anomalous Hall effect measurements on single crystalline metallic Fe3 GeTe2 nanoflakes with different thicknesses. These nanoflakes exhibit a single hard magnetic phase with a near square-shaped magnetic loop, large coercivity (up to 550 mT at 2 K), a Curie temperature near 200 K and strong perpendicular magnetic anisotropy...
April 19, 2018: Nature Communications
Scott P Oltman, Elizabeth E Rogers, Rebecca J Baer, James G Anderson, Martina A Steurer, Matthew S Pantell, J Colin Partridge, Larry Rand, Kelli K Ryckman, Laura L Jelliffe-Pawlowski
OBJECTIVE: To evaluate the association between early metabolic profiles combined with infant characteristics and survival past 7 days of age in infants born at 22-25 weeks of gestation. STUDY DESIGN: This nested case-control consisted of 465 singleton live births in California from 2005 to 2011 at 22-25 weeks of gestation. All infants had newborn metabolic screening data available. Data included linked birth certificate and mother and infant hospital discharge records...
April 13, 2018: Journal of Pediatrics
Peter I Macreadie, Dianne L McLean, Paul G Thomson, Julian C Partridge, Daniel O B Jones, Andrew R Gates, Mark C Benfield, Shaun P Collin, David J Booth, Luke L Smith, Erika Techera, Danielle Skropeta, Tammy Horton, Charitha Pattiaratchi, Todd Bond, Ashley M Fowler
For thousands of years humankind has sought to explore our oceans. Evidence of this early intrigue dates back to 130,000BCE, but the advent of remotely operated vehicles (ROVs) in the 1950s introduced technology that has had significant impact on ocean exploration. Today, ROVs play a critical role in both military (e.g. retrieving torpedoes and mines) and salvage operations (e.g. locating historic shipwrecks such as the RMS Titanic), and are crucial for oil and gas (O&G) exploration and operations. Industrial ROVs collect millions of observations of our oceans each year, fueling scientific discoveries...
April 11, 2018: Science of the Total Environment
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