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Cerebral cavernoma

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https://www.readbyqxmd.com/read/28314978/can-developmental-venous-anomalies-cause-seizures
#1
Claire Dussaule, Pascal Masnou, Ghaïdaa Nasser, Frédérique Archambaud, Cécile Cauquil-Michon, Jean-Paul Gagnepain, Viviane Bouilleret, Christian Denier
Developmental venous anomalies (DVAs) are congenital anatomical variants of normal venous drainage of normal brain. Although DVAs are often discovered on the occasion of a seizure, their involvement in epilepsy is poorly studied. Our objective was to determine whether DVA can cause seizures, in the cases where there is no associated lesion, including no cavernoma or dysplasia. Based on clinical history, cerebral MRI, EEG recording, and (18)F-FDG PET, we report 4 patients with DVA revealed by seizures. The first patient had a convulsive seizure caused by a hemorrhagic infarction due to thrombosis of her DVA...
March 17, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28208940/neurological-disorders-complicating-pregnancy-focus-on-obstetric-outcome
#2
Sandya Renukesh, Lavanya Rai
INTRODUCTION: Neurological disorders in pregnancy can be pregnancy related or can be caused by exacerbation of a pre-existing neurological condition or sometimes may even be detected for the first time during pregnancy in which it might be an incidental finding. The diagnosis and management of the neurological disorders in pregnancy is always a challenging task due to varied symptomatology and risks to the fetus. The evaluation and management should be performed in a stepwise fashion and requires multidisciplinary approach...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28068754/intraventricular-cavernous-malformation-review-of-the-literature-and-report-of-three-cases-with-neuroendoscopic-resection
#3
Masoud Shirvani, Alireza Hajimirzabeigi
Intraventricular cavernomas (IVCs) are extremely infrequent and only occur in 2.8 to 10% of patients with cerebral cavernomas. We describe three IVC cases and briefly review previously documented IVC cases in PubMed. Among 136 IVC cases, the mean age of the patients was 36.5 years; the male-to-female ratio was 0.8. The most frequent location was the lateral ventricle (52.6%), and most of the clinical symptoms (74%) were related to mass effects on adjacent brain tissues. Intraventricular hemorrhage occurred in 22...
January 9, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28061500/collision-tumor-composed-of-meningioma-and-cavernoma
#4
Jens Weigel, Markus Neher, Michael Schrey, Peter H Wünsch, Hans-Herbert Steiner
A true collision tumor is a rare entity composed of two histologically distinct neoplasms coinciding in the same organ. This paper reports a unique case of cerebral collision tumor consisting of two benign components. On the first hand, meningioma which is usually a benign lesion arising from the meningothelial cell in the arachnoidal membrane. On the other, cerebral cavernoma which is a well-circumscribed, benign vascular hamartoma within the brain. To our knowledge, there is no previously documented case of cerebral collision tumor consisting of two benign components...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27999514/hemorrhagic-stroke-resulting-from-venous-malformation-at-20-weeks-of-pregnancy
#5
Nicole D Ulrich, Elizabeth R Lapeyre, Robert C Moore
BACKGROUND: Stroke in the pregnant patient is not a common occurrence. Despite its relative rarity, stroke during pregnancy is associated with high morbidity and mortality for both mother and infant. We report the case of a patient who experienced a hemorrhagic stroke during pregnancy because of venous cavernoma. CASE REPORT: A 34-year-old patient, gravida 5 para 1-0-3-1, presented to labor and delivery triage at 21 weeks, 0 days' gestation with the concern of sudden-onset right-sided facial, arm, and leg numbness and weakness...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27890756/cavernous-angioma-of-the-cerebral-aqueduct
#6
Alberto Feletti, Stavros Dimitriadis, Giacomo Pavesi
BACKGROUND: Among the rare intraventricular cavernomas, purely intra-aqueductal cavernomas are exceptionally rare. CASE DESCRIPTION: A 62-year-old patient presented with progressive headache, memory loss, gait instability, and urinary incontinence. Magnetic resonance imaging showed the presence of a mass lesion located in the lumen of the cerebral aqueduct, associated with triventricular hydrocephalus. CONCLUSIONS: We discuss the rationale that led us to treat hydrocephalus with neuroendoscopy, which offered the possibility to directly inspect the intra-aqueductal lesion, make the diagnosis of cavernoma, and treat symptoms resulting from hydrocephalus without increasing the risk of bleeding...
February 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27790124/cerebral-cavernous-malformation-a-portuguese-family-with-a-novel-ccm1-mutation
#7
João Pedro Marto, Inês Gil, Sofia Calado, Miguel Viana-Baptista
INTRODUCTION: Cerebral cavernous malformation (CCM) is a vascular disorder characterized by the presence of central nervous system cavernomas. In familial forms, mutations in three genes (CCM1/KRIT1, CCM2/MGC4607 and CCM3/PDCD10) were identified. We describe a Portuguese family harboring a novel CCM1 mutation. CASE PRESENTATION: The proband is a woman who at the age of 55 years started to have complex partial seizures and episodic headache. Although nothing was found during her neurological examination, brain MRI showed bilateral, supra- and infratentorial cavernomas...
September 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27694117/radiation-induced-cerebral-vascular-malformations-at-biopsy
#8
B K Kleinschmidt-DeMasters, Kevin O Lillehei
Radiation-induced vascular "malformations", designated cavernous hemangiomas/cavernomas ("RICHs"), are seldom biopsied and are usually diagnosed based on neuroimaging features. They are an increasingly recognized complication of both CNS external beam radiation therapy and stereotactic radiosurgery. We identified 13 patients with radiation-induced vascular "malformations" in our surgical neuropathology databases searched from 2000 to 2016; 4 had received their therapy during childhood; 5 had received radiosurgery...
September 30, 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27651109/multiple-cerebrospinal-cavernous%C3%A2-angiomas
#9
M Kodeeswaran, Reshmi Udesh, L Ramya, S Jothi Kumar
Cavernous angiomas represent 5-12% of all spinal vascular lesions and 1% of all intramedullary lesions in pediatric patients. Intramedullary spinal cavernomas are relatively rare with only 24 cases reported till date to the best of our knowledge. A 15 -year-old boy presented to the clinic with acute onset motor weakness in all four limbs. He was diagnosed with multiple cerebral cavernomas and an acutely bleeding spinal cavernoma. Complete surgical excision of the spinal cavernoma was done. Postoperatively the patient's weakness gradually improved to a power of 4/5 in all his limbs over a period of 10 days...
September 20, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27562580/de%C3%A2-novo-formation-of-cerebral-cavernous-malformation-adjacent-to-existing-developmental-venous-anomaly-an-effect-of-change-in-venous-pressure-associated-with-management-of-a-complex-dural-arterio-venous-fistula
#10
Hariprakash Chakravarthy, Tzu-Kang Lin, Yao-Liang Chen, Yi-Ming Wu, Chin-Hua Yeh, Ho-Fai Wong
This is a case report of de novo development of two cerebral cavernous malformations adjacent to existing developmental venous anomalies. The development of cavernomas was noted over a follow-up period of 10 years. These developments happened during the course of staged endovascular management of a complex dural arterio-venous fistula along the right sphenoid wing. The patient presented with a proptosis secondary to lympho-haemangiomatous lesion of the fronto-orbital region and a high-flow right sphenoid wing dural arterio-venous fistula...
December 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27542564/quality-of-life-after-surgery-for-cerebral-cavernoma-brainstem-versus-nonbrainstem-location
#11
Jan Frederick Cornelius, Katharina Kürten, Igor Fischer, Daniel Hänggi, Hans Jakob Steiger
OBJECTIVE: We sought to analyze long-term outcome and quality of life after surgery of cerebral cavernomas (CCs) with special regard to localization (brainstem vs. nonbrainstem). METHODS: We conducted a retrospective study in a tertiary care center (2000-2010). Clinical charts were analyzed. Health-related quality of life (QoL) was evaluated with the Short Form-36 questionnaire. RESULTS: The study included 60 patients (21 male, 39 female, mean age 39...
November 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27423555/propranolol-stops-progressive-multiple-cerebral-cavernoma-in-an-adult-patient
#12
Matthias Reinhard, Florian Schuchardt, Stephan Meckel, Jürgen Heinz, Ute Felbor, Ulrich Sure, Ulrich Geisen
OBJECTIVE: To report a case of a patient with multiple cerebral cavernous malformations (CCM). OBSERVATION: A 22year old man with mild von Willebrand disease presented with two occipital CCM, one of them with acute hemorrhage. Genetic testing for CCM1-3 did not reveal a mutation. Over a period of 54months, the patient suffered 26 new CCM hemorrhages despite multiple treatment attempts including thalidomide, simvastatin and hemostatic factors. Only after initiation of propranolol, which has already been successfully used in three children with giant cerebral cavernoma, the occurrence of new CCM with hemorrhages was completely stopped already at dose of 30mg daily - now for a period of 26months and without any other medications...
August 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27367244/outcome-after-conservative-management-or-surgical-treatment-for-new-onset-epilepsy-in-cerebral-cavernous-malformation
#13
Philipp Dammann, Karsten Wrede, Ramazan Jabbarli, Salome Neuschulte, Katja Menzler, Yuan Zhu, Neriman Özkan, Oliver Müller, Michael Forsting, Felix Rosenow, Ulrich Sure
OBJECTIVE The aim of this study was to determine seizure outcome, functional outcome, and the withdrawal of antiepileptic drugs (AEDs) after conservative or surgical treatment of patients with new-onset cavernoma-related epilepsy (CRE). METHODS The authors conducted a retrospective comparative observational study of 79 consecutive patients, each with a single sporadic cerebral cavernous malformation (CCM) and new-onset CRE. RESULTS Forty-one patients underwent initial surgery (IS), and 38 patients underwent initial conservative (IC) treatment...
July 1, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27332076/neurocysticercosis-familial-cerebral-cavernomas-and-intracranial-calcifications-differential-diagnosis-for-adequate-management
#14
Emerson Leandro Gasparetto, Soniza Alves-Leon, Flavio Sampaio Domingues, João Thiago Frossard, Selva Paraguassu Lopes, Jorge Marcondes de Souza
Neurocysticercosis (NCC) is an endemic disease and important public health problem in some areas of the World and epilepsy is the most common neurological manifestation. Multiple intracranial lesions, commonly calcified, are seen on cranial computed tomography (CT) in the chronic phase of the disease and considered one of the diagnostic criteria of the diagnosis. Magnetic resonance imaging (MRI) is the test that better depicts the different stages of the intracranial cysts but does not show clearly calcified lesions...
June 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27203143/hemorrhage-from-cerebral-cavernous-malformations-a-systematic-pooled-analysis
#15
Bradley A Gross, Rose Du
OBJECTIVE The aim of this paper is to define an overall cavernous malformation (CM) hemorrhage rate and risk factors for hemorrhage. METHODS The authors performed a systematic, pooled analysis via the PubMed database through October 2015 using the terms "cavernoma," "cavernous malformation," "natural history," "bleeding," and "hemorrhage." English-language studies providing annual rates and/or risk factors for CM hemorrhage were included. Data extraction, performed independently by the authors, included demographic data, hemorrhage rates, and hemorrhage risk factors...
May 20, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27004758/hypothalamic-optochiasmatic-pilocytic-astrocytoma-associated-with-occipital-and-sacral-spinal-cavernomas-a-mere-coincidence-or-a-true-association
#16
Hussam Abou Al-Shaar, Amol Raheja, Cheryl A Palmer, Meic H Schmidt, William T Couldwell
BACKGROUND: The co-occurrence of cerebral gliomas and cavernous angiomas is rarely encountered in clinical practice. All reported cases with such association have occurred within the brain with none involving the spinal cord. CASE DESCRIPTION: The authors report the case of a hypothalamic-optochiasmatic pilocytic astrocytoma coexisting with right occipital and sacral spinal cavernomas. This 30-year-old man had an 8-year history of chronic lower back pain. Spinal magnetic resonance imaging (MRI) demonstrated an 8...
June 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26915699/endoscopic-endonasal-approach-to-mesencephalic-cavernous-malformations
#17
Shi-Ming He, Yuan Wang, Tian-Zhi Zhao, Tao Zheng, Wen-Hai Lv, Lan-Fu Zhao, Long Chen, Cole Sterling, Yan Qu, Guo-Dong Gao
BACKGROUND: Symptomatic cavernous malformations involving the brainstem are difficult to access by conventional approaches, which often require dramatic brain retraction to gain adequate operative corridor. Here, we present a successful endoscopic endonasal transclival approach for resection of a hemorrhagic, symptomatic mesencephalic cavernous malformation. CASE DESCRIPTION: A 20-year-old woman presented with acute onset of headache, nausea, and vomiting. Computed tomography scan revealed a ventral midbrain hemorrhage...
June 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26907387/the-embryo-placental-cd15-positive-vasculogenic-zones-as-a-source-of-propranolol-sensitive-pediatric-vascular-tumors
#18
L Seidmann, L Anspach, W Roth
OBJECTIVE: Propranolol-induced involution is a unique biological feature of some pediatric vascular tumors, for instance infantile hemangioma (IH), cerebral cavernoma or chorioangioma. Currently, the cellular origin of these distinct tumors is unclear. In this study, we tested the hypothesis that propranolol-responsive vascular tumors are derived from common vessel-forming CD15 + progenitor cells which occur in early gestation. The aim of this study was to identify the tumor-relevant CD15 + progenitors at the early stages of embryo-placental development...
February 2016: Placenta
https://www.readbyqxmd.com/read/26843561/heterogeneous-histopathology-of-cortical-microbleeds-in-cerebral-amyloid-angiopathy
#19
Susanne J van Veluw, Geert Jan Biessels, Catharina J M Klijn, Annemieke J M Rozemuller
OBJECTIVE: To investigate the histopathologic substrate of microbleeds detected on 7T postmortem MRI in autopsy cases with severe cerebral amyloid angiopathy (CAA) and Alzheimer pathology. METHODS: Five decedents (mean age at death 79.6 ± 5.7 years) with documented severe CAA and Alzheimer pathology on standard neuropathologic examination were selected from a local database. Formalin-fixed coronal brain slices were scanned at 7T MRI, including high-resolution T2- and T2*-weighted sequences...
March 1, 2016: Neurology
https://www.readbyqxmd.com/read/26839352/endothelial-cells-lining-sporadic-cerebral-cavernous-malformation-cavernomas-undergo-endothelial-to-mesenchymal-transition
#20
Luca Bravi, Matteo Malinverno, Federica Pisati, Noemi Rudini, Roberto Cuttano, Roberto Pallini, Maurizio Martini, Luigi Maria Larocca, Marco Locatelli, Vincenzo Levi, Giulio Andrea Bertani, Elisabetta Dejana, Maria Grazia Lampugnani
BACKGROUND AND PURPOSE: Cerebral cavernous malformation (CCM) is characterized by multiple lumen vascular malformations in the central nervous system that can cause neurological symptoms and brain hemorrhages. About 20% of CCM patients have an inherited form of the disease with ubiquitous loss-of-function mutation in any one of 3 genes CCM1, CCM2, and CCM3. The rest of patients develop sporadic vascular lesions histologically similar to those of the inherited form and likely mediated by a biallelic acquired mutation of CCM genes in the brain vasculature...
March 2016: Stroke; a Journal of Cerebral Circulation
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