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Cerebral cavernoma

B K Kleinschmidt-DeMasters, Kevin O Lillehei
Radiation-induced vascular "malformations", designated cavernous hemangiomas/cavernomas ("RICHs"), are seldom biopsied and are usually diagnosed based on neuroimaging features. They are an increasingly recognized complication of both CNS external beam radiation therapy and stereotactic radiosurgery. We identified 13 patients with radiation-induced vascular "malformations" in our surgical neuropathology databases searched from 2000 to 2016; 4 had received their therapy during childhood; 5 had received radiosurgery...
September 30, 2016: Journal of Neuropathology and Experimental Neurology
M Kodeeswaran, Reshmi Udesh, L Ramya, S Jothi Kumar
Cavernous angiomas represent 5-12% of all spinal vascular lesions and 1% of all intramedullary lesions in pediatric patients. Intramedullary spinal cavernomas are relatively rare with only 24 cases reported till date to the best of our knowledge. A 15 -year-old boy presented to the clinic with acute onset motor weakness in all four limbs. He was diagnosed with multiple cerebral cavernomas and an acutely bleeding spinal cavernoma. Complete surgical excision of the spinal cavernoma was done. Postoperatively the patient's weakness gradually improved to a power of 4/5 in all his limbs over a period of 10 days...
2016: Journal of Surgical Case Reports
Hariprakash Chakravarthy, Tzu-Kang Lin, Yao-Liang Chen, Yi-Ming Wu, Chin-Hua Yeh, Ho-Fai Wong
This is a case report of de novo development of two cerebral cavernous malformations adjacent to existing developmental venous anomalies. The development of cavernomas was noted over a follow-up period of 10 years. These developments happened during the course of staged endovascular management of a complex dural arterio-venous fistula along the right sphenoid wing. The patient presented with a proptosis secondary to lympho-haemangiomatous lesion of the fronto-orbital region and a high-flow right sphenoid wing dural arterio-venous fistula...
August 25, 2016: Neuroradiology Journal
Jan Frederick Cornelius, Katharina Kürten, Igor Fischer, Daniel Hänggi, Hans Jakob Steiger
OBJECTIVE: To analyze long-term outcome and quality of life after surgery of cerebral cavernomas (CC) with special regard to localization (brainstem vs. non-brainstem). METHODS: Retrospective study in a tertiary care center (2000-10). Clinical charts were analysed. Health-related quality of life (QoL) was evaluated with the Short Form-36 questionnaire. RESULTS: The study included 60 patients (21 m, 39 f, mean age 39.8 years). The distri-bution was: 67% supratentorial, 7% cerebellar and 26% brainstem...
August 16, 2016: World Neurosurgery
Matthias Reinhard, Florian Schuchardt, Stephan Meckel, Jürgen Heinz, Ute Felbor, Ulrich Sure, Ulrich Geisen
OBJECTIVE: To report a case of a patient with multiple cerebral cavernous malformations (CCM). OBSERVATION: A 22year old man with mild von Willebrand disease presented with two occipital CCM, one of them with acute hemorrhage. Genetic testing for CCM1-3 did not reveal a mutation. Over a period of 54months, the patient suffered 26 new CCM hemorrhages despite multiple treatment attempts including thalidomide, simvastatin and hemostatic factors. Only after initiation of propranolol, which has already been successfully used in three children with giant cerebral cavernoma, the occurrence of new CCM with hemorrhages was completely stopped already at dose of 30mg daily - now for a period of 26months and without any other medications...
August 15, 2016: Journal of the Neurological Sciences
Philipp Dammann, Karsten Wrede, Ramazan Jabbarli, Salome Neuschulte, Katja Menzler, Yuan Zhu, Neriman Özkan, Oliver Müller, Michael Forsting, Felix Rosenow, Ulrich Sure
OBJECTIVE The aim of this study was to determine seizure outcome, functional outcome, and the withdrawal of antiepileptic drugs (AEDs) after conservative or surgical treatment of patients with new-onset cavernoma-related epilepsy (CRE). METHODS The authors conducted a retrospective comparative observational study of 79 consecutive patients, each with a single sporadic cerebral cavernous malformation (CCM) and new-onset CRE. RESULTS Forty-one patients underwent initial surgery (IS), and 38 patients underwent initial conservative (IC) treatment...
July 1, 2016: Journal of Neurosurgery
Emerson Leandro Gasparetto, Soniza Alves-Leon, Flavio Sampaio Domingues, João Thiago Frossard, Selva Paraguassu Lopes, Jorge Marcondes de Souza
Neurocysticercosis (NCC) is an endemic disease and important public health problem in some areas of the World and epilepsy is the most common neurological manifestation. Multiple intracranial lesions, commonly calcified, are seen on cranial computed tomography (CT) in the chronic phase of the disease and considered one of the diagnostic criteria of the diagnosis. Magnetic resonance imaging (MRI) is the test that better depicts the different stages of the intracranial cysts but does not show clearly calcified lesions...
June 2016: Arquivos de Neuro-psiquiatria
Bradley A Gross, Rose Du
OBJECTIVE The aim of this paper is to define an overall cavernous malformation (CM) hemorrhage rate and risk factors for hemorrhage. METHODS The authors performed a systematic, pooled analysis via the PubMed database through October 2015 using the terms "cavernoma," "cavernous malformation," "natural history," "bleeding," and "hemorrhage." English-language studies providing annual rates and/or risk factors for CM hemorrhage were included. Data extraction, performed independently by the authors, included demographic data, hemorrhage rates, and hemorrhage risk factors...
May 20, 2016: Journal of Neurosurgery
Hussam Abou Al-Shaar, Amol Raheja, Cheryl A Palmer, Meic H Schmidt, William T Couldwell
BACKGROUND: The co-occurrence of cerebral gliomas and cavernous angiomas is rarely encountered in clinical practice. All reported cases with such association have occurred within the brain with none involving the spinal cord. CASE DESCRIPTION: The authors report the case of a hypothalamic-optochiasmatic pilocytic astrocytoma coexisting with right occipital and sacral spinal cavernomas. This 30-year-old man had an 8-year history of chronic lower back pain. Spinal magnetic resonance imaging (MRI) demonstrated an 8...
June 2016: World Neurosurgery
Shi-Ming He, Yuan Wang, Tian-Zhi Zhao, Tao Zheng, Wen-Hai Lv, Lan-Fu Zhao, Long Chen, Cole Sterling, Yan Qu, Guo-Dong Gao
BACKGROUND: Symptomatic cavernous malformations involving the brainstem are difficult to access by conventional approaches, which often require dramatic brain retraction to gain adequate operative corridor. Here, we present a successful endoscopic endonasal transclival approach for resection of a hemorrhagic, symptomatic mesencephalic cavernous malformation. CASE DESCRIPTION: A 20-year-old woman presented with acute onset of headache, nausea, and vomiting. Computed tomography scan revealed a ventral midbrain hemorrhage...
June 2016: World Neurosurgery
L Seidmann, L Anspach, W Roth
OBJECTIVE: Propranolol-induced involution is a unique biological feature of some pediatric vascular tumors, for instance infantile hemangioma (IH), cerebral cavernoma or chorioangioma. Currently, the cellular origin of these distinct tumors is unclear. In this study, we tested the hypothesis that propranolol-responsive vascular tumors are derived from common vessel-forming CD15 + progenitor cells which occur in early gestation. The aim of this study was to identify the tumor-relevant CD15 + progenitors at the early stages of embryo-placental development...
February 2016: Placenta
Susanne J van Veluw, Geert Jan Biessels, Catharina J M Klijn, Annemieke J M Rozemuller
OBJECTIVE: To investigate the histopathologic substrate of microbleeds detected on 7T postmortem MRI in autopsy cases with severe cerebral amyloid angiopathy (CAA) and Alzheimer pathology. METHODS: Five decedents (mean age at death 79.6 ± 5.7 years) with documented severe CAA and Alzheimer pathology on standard neuropathologic examination were selected from a local database. Formalin-fixed coronal brain slices were scanned at 7T MRI, including high-resolution T2- and T2*-weighted sequences...
March 1, 2016: Neurology
Luca Bravi, Matteo Malinverno, Federica Pisati, Noemi Rudini, Roberto Cuttano, Roberto Pallini, Maurizio Martini, Luigi Maria Larocca, Marco Locatelli, Vincenzo Levi, Giulio Andrea Bertani, Elisabetta Dejana, Maria Grazia Lampugnani
BACKGROUND AND PURPOSE: Cerebral cavernous malformation (CCM) is characterized by multiple lumen vascular malformations in the central nervous system that can cause neurological symptoms and brain hemorrhages. About 20% of CCM patients have an inherited form of the disease with ubiquitous loss-of-function mutation in any one of 3 genes CCM1, CCM2, and CCM3. The rest of patients develop sporadic vascular lesions histologically similar to those of the inherited form and likely mediated by a biallelic acquired mutation of CCM genes in the brain vasculature...
March 2016: Stroke; a Journal of Cerebral Circulation
Nicolae Sarbu, Teresa Pujol, Laura Oleaga
Hyperintense perilesional edema in brain masses on T1-weighted images (T1WI) is an unusual radiological finding. We report three cases showing this particular type of edema, one representing cerebral hemorrhagic cavernous malformation (CCM, cavernoma) and the other two, metastases of melanoma. The association between this sign and cavernoma was recently recognized. On the other hand, in melanotic lesions, the relationship with T1WI-hyperintense perilesional edema has not yet been described. Despite being an infrequent sign, it can considerably narrow the differential diagnosis, which gives it a high value for clinical practice...
February 2016: Neuroradiology Journal
Ale Algra, Gabriël J E Rinkel
No abstract text is available yet for this article.
December 1, 2015: Lancet Neurology
Lucas Crociati Meguins, Rodrigo Antônio Rocha da Cruz Adry, Sebastião Carlos da Silva Júnior, Carlos Umberto Pereira, Jean Gonçalves de Oliveira, Dionei Freitas de Morais, Gerardo Maria de Araújo Filho, Lúcia Helena Neves Marques
BACKGROUND: Mesiotemporal cavernous malformation can occur in 10-20% of patients with cerebral cavernomas and are frequently associated with refractory. METHODS: A retrospective investigation was performed in the epilepsy clinic of a Brazilian tertiary referral epilepsy center, from January 2000 to March 2012. RESULTS: A total of 21 patients were included in the study. Thirteen patients (62%) evolved to Engel I; 5 (24%) to Engel II, 2 (10%) to Engel III, and 1 (5%) to Engel IV...
2015: Surgical Neurology International
Roberto Cuttano, Noemi Rudini, Luca Bravi, Monica Corada, Costanza Giampietro, Eleanna Papa, Marco Francesco Morini, Luigi Maddaluno, Nicolas Baeyens, Ralf H Adams, Mukesh K Jain, Gary K Owens, Martin Schwartz, Maria Grazia Lampugnani, Elisabetta Dejana
Cerebral cavernous malformations (CCMs) are vascular malformations located within the central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is needed, since current therapy is limited to neurosurgery. Familial CCM is caused by loss-of-function mutations in any of Ccm1, Ccm2, and Ccm3 genes. CCM cavernomas are lined by endothelial cells (ECs) undergoing endothelial-to-mesenchymal transition (EndMT). This switch in phenotype is due to the activation of the transforming growth factor beta/bone morphogenetic protein (TGFβ/BMP) signaling...
January 2016: EMBO Molecular Medicine
V A Khachatryan, A V Kim, K A Samochernykh, V S Sidorin, T V Sokolova, O A Don, V P Ivanov
OBJECTIVE: The study presents a clinical observation of foreign body granuloma, which is rare productive inflammation, developed on treatment with a hemostatic material upon removal of cerebral cavernoma. MATERIAL AND METHODS: A 4-year-old boy operated on for left parietal lobe cavernoma was diagnosed with a mass lesion during a follow-up MRI examination 4 months after surgery. The patient was re-operated in connection with suspected abscess formation. The pathological tissue was subjected to the histological and immunohistochemical examination...
2015: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Dilok Tantongtip, Uwe Spetzger, Sebastian Arnold, Andrej von Schilling, George Kiriyanthan
BACKGROUND: A developmental venous anomaly (DVA) associated with cerebral cavernous malformation (CCM) is the most common combined vascular malformation. Microsurgical resection of the CCM and avoidance of damage to the adjacent DVA is an overall accepted treatment regimen. Several publications have demonstrated serious consequences that possibly occur after damage of the associated DVA. Conversely, some authors have reported cases of injured DVAs without any relevant postoperative complications...
March 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Juri Kivelev, Felix Göhre, Mika Niemelä, Juha Hernesniemi
BACKGROUND: We analyze our experience of using TachoSil® (Takeda Austria GmbH: Linz, Austria) in microneurosurgical procedures as a hemostat and also as a sealant to patch dural defects. MATERIALS AND METHODS: Beginning on January 1, 2012, we prospectively analyzed 100 consecutive surgeries where TachoSil was used. The patient group included 58 women (58 %) and 42 men (42 %); the mean age was 52 years (range, 3-85 years). Indications for surgery included removal of the tumor (53 cases; 53 %), clipping of the cerebral arterial aneurysm (31 cases; 31 %), and treatment of other pathologies, including AVM (four cases; 4 %), cavernomas (four cases; 4 %), spinal tumor, and traumatic subdural hematoma...
September 2015: Acta Neurochirurgica
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