Mattia Busana, Carmelo Zinnato, Federica Romitti, Michela Palumbo, Simone Gattarello, Aurelio Sonzogni, Ann-Kathrin Gersmann, Annika Richter, Peter Herrmann, Günter Hahn, Serena Brusatori, Roberta Maj, Mara Velati, Onnen Moerer, Konrad Meissner, Tom Barnes, Michael Quintel, John J Marini, Luciano Gattinoni
The amount of energy delivered to the respiratory system is recognized as a cause of ventilator-induced lung injury (VILI). How energy dissipation within the lung parenchyma causes damage is still a matter of debate. Expiratory flow control has been proposed as a strategy to reduce the energy dissipated into the respiratory system during expiration and, possibly, VILI. We studied 22 healthy pigs (29 ± 2 kg), which were randomized into a control ( n = 11) and a valve group ( n = 11), where the expiratory flow was controlled through a variable resistor...
November 1, 2022: Journal of Applied Physiology