keyword
MENU ▼
Read by QxMD icon Read
search

Volume of tissue activated

keyword
https://www.readbyqxmd.com/read/29144576/molecular-reproduction-development-volume-84-issue-11-november-2017
#1
(no author information available yet)
Ctenophores, also known as comb jellies, are non-bilaterian invertebrates and nearly all are self-fertile hermaphrodites. Mnemiopsis leidyi is a particularly useful model for the study of cellular, tissue, and organ patterning in ctenophores due to their extreme transparency, as seen in these adults. The locomotory ctene rows, highlighted by iridescence, overlie the germ line, from which gametes and embryos are readily available in large numbers. In this issue, Davidson et al. characterize transcript expression and timing of the maternal-to-zygotic transition and accompanying zygotic genome activation during early embryogenesis in this ctenophore...
November 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29143998/oxytocin-mediates-the-beneficial-effects-of-the-exercise-training-on-breast-cancer
#2
Ali Mohammad Alizadeh, Zahra Heydari, Mostafa Rahimi, Behzad Bazgir, Hossein Shirvani, Sadaf Alipour, Yassaman Heidarian, Solmaz Khalighfard, Amin Isanejad
Exercise training can affect the breast tumor growth. We hypothesized that exercise training may reduce breast tumor growth by inducing Oxytocin (OT) secretion and its related signaling pathways such as PI3K/AKT and ERK. Therefore fifty-six BALB/c mice were equally divided into seven groups to study the effects of OT and atosiban (an oxytocin receptor antagonist) together with the interval exercise training on breast tumor growth, as well as tumor related signaling pathways including PI3K/AKT and ERK. Animal weight, OT plasma level, tumor weight and volume measured at the end of study...
November 16, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29140736/extremely-low-frequency-magnetic-field-protects-injured-spinal-cord-from-the-microglia-and-iron-induced-tissue-damage
#3
Soumil Dey, Samrat Bose, Suneel Kumar, Ravinder Rathore, Rashmi Mathur, Suman Jain
Spinal cord injury (SCI) is insult to the spinal cord, which results in loss of sensory and motor function below the level of injury. SCI results in both immediate mechanical damage and secondary tissue degeneration. Following traumatic insult, activated microglia release proinflammatory cytokines and excess iron due to hemorrhage, initiating oxidative stress that contributes to secondary degeneration. Literature suggests that benefits are visible with the reduction in concentration of iron and activated microglia in SCI...
November 15, 2017: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/29137853/antidiabetic-antihyperlipidemic-activities-and-herb-drug-interaction-of-a-polyherbal-formulation-in-streptozotocin
#4
Vishnu P Choudhari, Ketkee P Gore, Anil T Pawar
BACKGROUND: Ojamin (OJ), a polyherbal antidiabetic formulation, is extensively used as a food supplement to control diabetes alone or along with synthetic antidiabetic agents. However, it's phytochemical and pharmacological investigations are lacking. OBJECTIVE: The present study was undertaken to study antidiabetic and antihyperlipidemic potentials of OJ and its interaction with Metformin in streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: Diabetes was induced in Wistar rats by single intraperitoneal (i...
November 11, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29137852/dysarthria-in-pallidal-deep-brain-stimulation-in-dystonia-depends-on-the-posterior-location-of-active-electrode-contacts-a-pilot-study
#5
K A M Pauls, P J Bröckelmann, S Hammesfahr, J Becker, A Hellerbach, V Visser-Vandewalle, T A Dembek, I G Meister, L Timmermann
BACKGROUND: Pallidal Deep Brain Stimulation (GPi-DBS) is an efficient treatment for primary dystonia. We investigated stimulation-induced dysarthria, which is the most frequent side-effect of GPi-DBS. METHODS: Speech was recorded while reading a standard text, and performing rapid syllable repetitions ON and OFF DBS in ten dystonia patients (6 men; 3 cervical, 4 segmental, 3 generalized, unselected for DBS-related speech impairments). Speech and articulation rate, pauses, and syllable repetition rates were extracted via acoustic analysis...
November 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29136948/gastroprotective-effect-and-mode-of-action-of-methanol-extract-of-sphenodesme-involucrata-var-paniculata-c-b-clarke-munir-lamiaceae-leaves-on-experimental-gastric-ulcer-models
#6
Puthanpura Sasidharan Sreeja, Karuppusamy Arunachalam, Sathyanarayanan Saikumar, Muniyandi Kasipandi, Sivaraj Dhivya, Rajan Murugan, Thangaraj Parimelazhagan
Sphenodesme involucrata var. paniculata (C. B. Clarke) Munir, endemic to South Asia, is used by tribal for alleviation from abdominal disorders, inflammation and body pain. However, the gastroprotective properties of this species have not yet been studied. The leaves of S. involucrata were extracted by Soxhlet extraction using different solvents successively and the extracts were analyzed for antioxidant and anti-Helicobacter pylori activities using different in vitro assays. The chemical composition of methanol extract of S...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29135963/comprehensive-survey-on-improved-focality-and-penetration-depth-of-transcranial-magnetic-stimulation-employing-multi-coil-arrays
#7
Xile Wei, Yao Li, Meili Lu, Jiang Wang, Guosheng Yi
Multi-coil arrays applied in transcranial magnetic stimulation (TMS) are proposed to accurately stimulate brain tissues and modulate neural activities by an induced electric field (EF). Composed of numerous independently driven coils, a multi-coil array has alternative energizing strategies to evoke EFs targeting at different cerebral regions. To improve the locating resolution and the stimulating focality, we need to fully understand the variation properties of induced EFs and the quantitative control method of the spatial arrangement of activating coils, both of which unfortunately are still unclear...
November 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29135861/in-vitro-and-in-vivo-antimelanoma-effect-of-ethyl-ester-cyclohexyl-analog-of-ethylenediamine-dipropanoic-acid
#8
Andjelka M Isakovic, Sasa M Petricevic, Slavica M Ristic, Dusan M Popadic, Tamara K Kravic-Stevovic, Nevena S Zogovic, Jelena M Poljarevic, Tatjana V Zivanovic Radnic, Tibor J Sabo, Aleksandra J Isakovic, Ivanka D Markovic, Vladimir S Trajkovic, Sonja T Misirlic-Dencic
Melanoma, an aggressive skin tumor with high metastatic potential, is associated with high mortality and increasing morbidity. Multiple available chemotherapeutic and immunotherapeutic modalities failed to improve survival in advanced disease, and the search for new agents is ongoing. The aim of this study was to investigate antimelanoma effects of O,O-diethyl-(S,S)-ethylenediamine-N,N'di-2-(3-cyclohexyl) propanoate dihydrochloride (EE), a previously synthesized and characterized organic compound. Mouse melanoma B16 cell viability was assessed using acid phosphatase, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, sulforhodamine B, and lactate dehydrogenase assays...
November 13, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29134925/effects-of-ssri-exposure-on-hemorrhagic-complications-and-outcome-following-thrombolysis-in-ischemic-stroke
#9
Schellen Christoph, Ferrari Julia, Lang Wilfried, Sykora Marek
Background Selective serotonin reuptake inhibitors (SSRI) may interfere with platelet function, and pre-stroke SSRI treatment has been associated with increased hematoma volumes and mortality in hemorrhagic stroke patients. The effects of SSRI on the risk of hemorrhagic complications after thrombolysis in ischemic stroke patients are unclear. Aims To examine the effects of pre-stroke SSRI exposure on bleeding complications, functional outcome, and mortality following thrombolysis in ischemic stroke. Methods Data including standard demographic and clinical variables as well as baseline and follow-up stroke severity (measured by National Institutes of Health Stroke Score), functional outcome (measured by modified Rankin Scale) at 3 months, and mortality at 7 and 90 days were extracted from the Virtual International Stroke Trials Archive...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29132243/protective-effects-of-estradiol-and-dihydrotestosterone-following-spinal-cord-injury
#10
Dale R Sengelaub, Qi Han, Nai-Kui Liu, Melissa Maczuga, Violetta Szalavari, Stephanie Valencia, Xiao-Ming Xu
Spinal cord injury (SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. We previously demonstrated that motoneurons, and the muscles they innervate, show pronounced atrophy after SCI, and these changes are prevented by treatment with testosterone. Here we assessed if the testosterone active metabolites, estradiol and dihydrotestosterone, have similar protective effects after SCI. Young adult female rats received either sham or T9 spinal cord contusion injuries and were treated with estradiol, dihydrotestosterone, both, or nothing via Silastic capsules...
November 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29131497/development-of-endothelial-cell-networks-in-3d-tissues-by-combination-of-melt-electrospinning-writing-with-cell-accumulation-technology
#11
Sarah Bertlein, Daichi Hikimoto, Gernot Hochleitner, Julia Hümmer, Tomasz Jungst, Michiya Matsusaki, Mitsuru Akashi, Jürgen Groll
A remaining challenge in tissue engineering approaches is the in vitro vascularization of engineered constructs or tissues. Current approaches in engineered vascularized constructs are often limited in the control of initial vascular network geometry, which is crucial to ensure full functionality of these constructs with regard to cell survival, metabolic activity, and potential differentiation ability. Herein, the combination of 3D-printed poly-ε-caprolactone scaffolds via melt electrospinning writing with the cell-accumulation technique to enable the formation and control of capillary-like network structures is reported...
November 13, 2017: Small
https://www.readbyqxmd.com/read/29128573/26-week-oral-chronic-toxicity-study-of-geniposide-in-rats
#12
Jingzhuo Tian, Yan Yi, Yong Zhao, Chunying Li, Yushi Zhang, Lianmei Wang, Chen Pan, Jiayin Han, Guiqin Li, Xiaolong Li, Jing Liu, Nuo Deng, Yue Gao, Aihua Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Geniposide, the major active constituent of Fructus Gardeniae (FG), has been widely used to treat the various diseases in China. AIM OF THE STUDY: The chronic toxicity study was conducted to investigate the safety of Geniposide. MATERIALS AND METHODS: Sprague-Dawley (SD) rats of both sexes were administered orally Geniposide 25, 50, 100mg/kg by gavage once daily at volume of 10mL/kg for 26 weeks repeated. Endpoints evaluated included clinical observations, food consumption, body weights, blood biochemistry, hematology, and histomorphological observation...
November 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29126301/coagulation-testing-in-the-core-laboratory
#13
William E Winter, Sherri D Flax, Neil S Harris
Primary hemostasis begins with endothelial injury. VWF, produced by endothelial cells, binds to platelets and links them to subendothelial collagen. Platelet-derived ADP and thromboxane activate non-adhered platelets via their GPIIb/IIIa receptors, allowing these platelets to participate in platelet aggregation. Secondary hemostasis is initiated with the binding of factor VII to extravascular tissue factor (TF). Factors II, VII, IX and X are vitamin K-dependent factors. The role of vitamin K is to assist in the addition of gamma carboxylate groups to glutamic acids in the "GLA" domains of these factors...
November 8, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29122620/three-year-outcomes-of-the-prospective-randomized-controlled-rez%C3%A5-m-system-study-convective-radiofrequency-thermal-therapy-for-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#14
Kevin T McVary, Claus G Roehrborn
OBJECTIVE: To report 3-year outcomes of a prospective, multi-center, randomized, blinded control trial after treatment with convective radiofrequency (RF) water vapor thermal therapy for moderate to severe lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: Fifteen centers enrolled and randomized 197 men ≥50 years old with International Prostate Symptom Score (IPSS) ≥13, maximum flow rate (Qmax) ≤15 ml/s and prostate volume 30 to 80 cc to thermal therapy with Rezūm® System or control (2:1)...
November 6, 2017: Urology
https://www.readbyqxmd.com/read/29122552/nephroprotection-through-the-akt-enos-pathway-by-centrally-administered-erythropoietin-in-a-rat-model-of-fixed-volume-hemorrhage
#15
Behjat Seifi, Mehri Kadkhodaee, Mina Ranjbaran, Enayatollah Bakhshi
AIMS: This study was designed to investigate the protective effects of centrally administered erythropoietin (EPO) on brain oxidative stress and inflammatory markers to protect the kidneys during hemorrhagic shock (HS). MAIN METHODS: Animals were assigned into three groups (n=6). Sham rats were subjected to cannulation of femoral artery and vein as well as stereotaxic surgery. In HS group, 50% of total blood volume was withdrawn and resuscitation was started 2h later...
November 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29122550/supply-and-demand-how-does-variation-in-atmospheric-oxygen-during-development-affect-insect-tracheal-and-mitochondrial-networks
#16
John M VandenBrooks, Gregory Gstrein, Jason Harmon, Jessica Friedman, Matthew Olsen, Anna Ward, Gregory Parker
Atmospheric oxygen is one of the most important atmospheric component for all terrestrial organisms. Variation in atmospheric oxygen has wide ranging effects on animal physiology, development, and evolution. This variation in oxygen has the potential to affect both respiratory systems (the supply side) and mitochondrial networks (the demand side) in animals. Insect respiratory systems supplying oxygen to tissues in the gas phase through blind ended tracheal systems are particularly susceptible to this variation...
November 6, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29121900/synergistic-gastroprotective-activity-of-methanolic-extract-of-a-mixture-of-melastoma-malabathricum-and-muntingia-calabura-leaves-in-rats
#17
Siti Zawanah Halim, Zainul Amiruddin Zakaria, Maizatul Hasyima Omar, Norhafizah Mohtarrudin, Ikarastika Rahayu Abdul Wahab, Muhammad Nazrul Hakim Abdullah
BACKGROUND: Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an attempt to develop a pharmaceutical product with antiulcer potential, the synergistic gastroprotective activity of methanolic extract of a mixture of MM and MC (MMMC) at various ratios was evaluated in rat models. METHODS: Rats were pre-treated orally with 2% Tween 80 (vehicle), 100 mg/kg ranitidine (reference drug) or MMMC (ratios of 1:1, 1:3 and 3:1 (v/v); doses of 15, 150 or 300 mg/kg) and then subjected to the ethanol-induced gastric ulcer or pyloric ligation assays...
November 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29120692/epithelial-na-channel-regulation-by-extracellular-and-intracellular-factors
#18
Thomas R Kleyman, Ossama B Kashlan, Rebecca P Hughey
Epithelial Na(+) channels (ENaCs) are members of the ENaC/degenerin family of ion channels that evolved to respond to extracellular factors. In addition to being expressed in the distal aspects of the nephron, where ENaCs couple the absorption of filtered Na(+) to K(+) secretion, these channels are found in other epithelia as well as nonepithelial tissues. This review addresses mechanisms by which ENaC activity is regulated by extracellular factors, including proteases, Na(+), and shear stress. It also addresses other factors, including acidic phospholipids and modification of ENaC cytoplasmic cysteine residues by palmitoylation, which enhance channel activity by altering interactions of the channel with the plasma membrane...
November 8, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/29119565/non-invasive-methods-for-the-assessment-of-brown-adipose-tissue-in-humans
#19
Maria Chondronikola, Scott Beeman, Richard L Wahl
Brown adipose tissue (BAT) is a recently rediscovered tissue in people that has shown promise as a potential therapeutic target against obesity and its metabolic abnormalities. Reliable non-invasive assessment of BAT volume and activity is critical to allow evaluating its importance for metabolic control. Positron emission tomography/computed tomography (PET/CT) in combination with 2-deoxy-2-[(18) F]fluoroglucose ((18) F-FDG) administration is currently the most frequently used and most established method for the detection and quantification of activated BAT in humans...
November 8, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29117205/hypoxia-preconditioned-mesenchymal-stem-cells-ameliorate-ischemia-reperfusion-induced-lung-injury
#20
Yung-Yang Liu, Chi-Huei Chiang, Shih-Chieh Hung, Chih-Feng Chian, Chen-Liang Tsai, Wei-Chih Chen, Haibo Zhang
BACKGROUND: Hypoxia preconditioning has been proven to be an effective method to enhance the therapeutic action of mesenchymal stem cells (MSCs). However, the beneficial effects of hypoxic MSCs in ischemia/reperfusion (I/R) lung injury have yet to be investigated. In this study, we hypothesized that the administration of hypoxic MSCs would have a positive therapeutic impact on I/R lung injury at molecular, cellular, and functional levels. METHODS: I/R lung injury was induced in isolated and perfused rat lungs...
2017: PloS One
keyword
keyword
31429
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"