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https://www.readbyqxmd.com/read/28550811/influence-of-solids-residence-time-and-carbon-storage-on-nitrogen-and-phosphorus-recovery-by-microalgae-across-diel-cycles
#1
D A Gardner-Dale, I M Bradley, J S Guest
Microalgal treatment systems could advance nutrient recovery from wastewater by achieving effluent nitrogen (N) and phosphorus (P) levels below the current limit of technology, but their successful implementation requires an understanding of how design decisions influence nutrient uptake over daily (i.e., diel) cycles. This work demonstrates the ability to influence microalgal N:P recovery ratio via solids residence time (SRT) while maintaining complete nutrient removal across day/night cycles through carbon storage and mobilization...
May 18, 2017: Water Research
https://www.readbyqxmd.com/read/28550810/rigid-aromatic-linking-moiety-in-cationic-lipids-for-enhanced-gene-transfection-efficiency
#2
Bing Wang, Rui-Mo Zhao, Ji Zhang, Yan-Hong Liu, Zheng Huang, Qing-Ying Yu, Xiao-Qi Yu
Although numerous cationic lipids have been developed as non-viral gene vectors, the structure-activity relationship (SAR) of these materials remains unclear and needs further investigation. In this work, a series of lysine-derived cationic lipids containing linkages with different rigidity were designed and synthesized. SAR studies showed that lipids with rigid aromatic linkage could promote the formation of tight liposomes and enhance DNA condensation, which is essential for the gene delivery process. These lipids could give much higher transfection efficiency than those containing more flexible aliphatic linkage in various cell lines...
May 17, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28550807/effects-of-waterborne-copper-delivered-under-two-different-exposure-and-salinity-regimes-on-osmotic-and-ionic-regulation-in-the-mudflat-fiddler-crab-minuca-rapax-ocypodidae-brachyura
#3
Mariana V Capparelli, John C McNamara, Martin Grosell
The effects of exposure to copper (Cu) on tissue Cu accumulation, on hemolymph osmotic, Na(+) and Cl(-) regulation, and on gill Na(+)/K(+)-ATPase (NKA) and carbonic anhydrase (CA) activities were evaluated in the fiddler crab Minuca rapax. Waterborne copper was delivered to the crabs at one of three salinities (seawater at 25‰ salinity [S] = isosmotic control; distilled water [<0.1‰ S] = hypo-osmotic medium; or 60‰ S = hyper-osmotic seawater) either for 5 days in a 0.5-cm water film containing 0, 50, 150, 250 or 500µg Cu/L with free access to a dry surface, or in crabs fully submerged for 5h at 0, 250 or 500µg Cu/L...
May 24, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28550802/mechanism-of-action-of-three-newly-registered-drugs-for-multiple-sclerosis-treatment
#4
REVIEW
Kaja Kasarełło, Agnieszka Cudnoch-Jędrzejewska, Andrzej Członkowski, Dagmara Mirowska-Guzel
Multiple sclerosis (MS) is a disease of suspected autoimmune origin leading to neurodegeneration. The disease pathomechanism is considered to be primarily based on neuroinflammation directed against myelin antigens caused by autoreactive T cells. MS etiology remains still unknown, which makes it difficult to create an efficient therapy, therefore, MS treatment targets mechanisms involved in disease pathology. In this review, we present the mechanism of action of three newly registered drugs for MS. Dimethyl fumarate (DMF) is an agent presenting a broad spectrum of action...
February 22, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28550801/the-nk-1-receptor-antagonist-l-732-138-induces-apoptosis-in-human-gastrointestinal-cancer-cell-lines
#5
Miguel Muñoz, Marisa Rosso, Rafael Coveñas
BACKGROUND: Gastric and colon cancer cells express the neurokinin-1 receptor (NK-1R) and the peptide substance P (SP), after binding to this receptor, elicits the proliferation of gastrointestinal cancer cells and an antiapoptotic effect. In these cells, NK-1R antagonists (L-733,060: a piperidine derivative; aprepitant: a morpholine derivative) block, after binding to the NK-1R, the action of SP and exert an antiproliferative action, both antagonists promote apoptosis and the death of cancer cells...
February 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28550797/potential-tracers-for-tracking-septic-tank-effluent-discharges-in-watercourses
#6
Samia Richards, Paul J A Withers, Eric Paterson, Colin W McRoberts, Marc Stutter
Septic tank effluent (STE) contributes to catchment nutrient and pollutant loads. To assess the role of STE discharges in impairment of surface water, it is essential to identify the sources of pollution by tracing contaminants in watercourses. We examined tracers that were present in STE to establish their potential for identifying STE contamination in two stream systems (low and high dilution levels) against the background of upstream sources. The studied tracers were microbial, organic matter fluorescence, caffeine, artificial sweeteners and effluent chemical concentrations...
May 24, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28550790/trophic-fate-of-inorganic-and-methyl-mercury-in-a-macrophyte-chironomid-food-chain
#7
Rebecca Beauvais-Flück, Frédéric Gimbert, Ophélie Méhault, Claudia Cosio
Dietary transfer of mercury (Hg) is central for its effects on higher trophic animals, nonetheless, its driving parameters and characteristics are not well understood. Here we measured Hg species transfer (uptake) from the macrophyte Elodea nuttallii -mimicking tissues incorporation in sediments after decay- to Chironomus riparius. Methyl-Hg (MMHg) was more transferable than inorganic Hg (IHg) from plant's intracellular and cell wall compartments. After 10-d-long exposure, MMHg was predominantly found in MMHg form in the cytosolic compartment (S) of chironomids, while IHg showed similar concentrations in S and insoluble debris (P) compartments...
May 17, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28550783/occurrence-distribution-and-bioaccumulation-behaviour-of-hydrophobic-organic-contaminants-in-a-large-scale-constructed-wetland-in-singapore
#8
Qian Wang, Barry C Kelly
This study involved a field-based investigation to assess the occurrence, distribution and bioaccumulation behaviour of hydrophobic organic contaminants in a large-scale constructed wetland. Samples of raw leachate, water and wetland plants, Typha angustifolia, were collected for chemical analysis. Target contaminants included polychlorinated biphenyls (PCBs), organochlorine pesticides (OCP), as well as several halogenated flame retardants (HFRs) and personal care products (triclosan and synthetic musks). In addition to PCBs and OCPs, synthetic musks, triclosan (TCS) and dechlorane plus stereoisomers (syn- and anti-DPs) were frequently detected...
May 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28550765/social-and-academic-premorbid-adjustment-domains-predict-different-functional-outcomes-among-youth-with-first-episode-mania
#9
Aswin Ratheesh, Christopher G Davey, Rothanthi Daglas, Craig Macneil, Melissa Hasty, Kate Filia, Patrick D McGorry, Michael Berk, Philippe Conus, Sue Cotton
BACKGROUND: Premorbid characteristics may help predict the highly variable functional and illness outcomes of young people with early stage Bipolar Disorder (BD). We sought to examine the relationships between premorbid adjustment and short to medium-term outcomes after a first treated episode of mania. METHODS: We examined the baseline and 18-month follow-up characteristics of 117 participants with first episode of mania, treated at two tertiary early intervention services in Melbourne, Australia...
May 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28550722/inflammasome-expression-and-cytomegalovirus-viremia-in-critically-ill-patients-with-sepsis
#10
Nina Singh, Makoto Inoue, Ryosuke Osawa, Marilyn M Wagener, Mari L Shinohara
BACKGROUND: CMV viremia is a contributor to poor outcomes in critically ill patients with sepsis. OBJECTIVES: To assess the expression levels of genes encoding inflammasome-related proteins in the development of CMV viremia in critically ill patients with sepsis. STUDY DESIGN: A cohort of CMV-seropositive critically ill patients with sepsis due to bloodstream infection underwent weekly testing for CMV viremia. Blood samples to evaluate mRNA levels of genes encoding CASP1, ASC, NLRP1, NLRP3, and NLRP12 were collected at the time of enrollment...
May 18, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28550697/early-rehabilitation-for-patients-with-hip-fractures-spreading-change-across-the-system
#11
Charissa Levy, Sharon Ocampo-Chan, Linda Huestis, Donna Renzetti
Evidence suggests that patients with hip fractures should begin rehabilitation no later than six days following surgery. The reality is often far different. In an initiative led by the Greater Toronto Area (GTA) Rehab Network, acute care and rehab/complex continuing care hospitals across the GTA have implemented a new early referral process to aid transition of patients from acute care to inpatient rehabilitation as early as possible to improve their outcomes. Two of the participating acute care hospitals have now surpassed the six-day target and two others are within range...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28550688/long-noncoding-rna-crnde-prc2-participated-in-the-radiotherapy-resistance-of-human-lung-adenocarcinoma-through-targeting-p21-expression
#12
Ming Zhang, Change Gao, Yi Yang, Gaofeng Li, Jian Dong, Yiqin Ai, Nan Chen, Wenhui Li
Long noncoding RNAs (lncRNAs), as new class of functional regulators involved in human tumorigenesis, have been attracting increasing attention of researchers. The lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE), transcribed from chromosome 16 on the strand opposite to the adjacent IRX5 gene, were originally found to be increased in CRC and was reported abnormal expressed in many cancers. However, its potential role and molecular mechanism underlying radioresistant phenotype formation of lung adenocarcinoma (LAD) remains unclear...
May 17, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550687/tanshinone-suppresses-arecoline-induced-epithelial-mesenchymal-transition-in-oral-submucous-fibrosis-by-epigenetically-reactivating-the-p53-pathway
#13
Lian Zheng, Zhen-Jie Guan, Wen-Ting Pan, Tian-Fang Du, Yu-Jia Zhai, Jia Guo
Oral submucous fibrosis (OSF) induced by the chewing of areca nut has been considered as a precancerous lesion with a higher probability of developing oral squamous cell carcinoma. Tanshinone (TSN) is the main component extracted from Salvia miltiorrhiza, a traditional Chinese medicine, which was found to have diverse pharmacological effects such as anti-inflammatory and anti-tumor effects. In current study, we aim to identify inhibitory effects and the underlying mechanism of Tanshinone on OSF progress. We found that treatment of TSN inhibited arecoline-mediated proliferation of primary human oral mucosal fibroblasts, and reversed the promotive effects of arecoline on EMT process...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550686/microrna-186-suppresses-cell-proliferation-and-metastasis-through-targeting-sentrin-specific-protease-1-in-renal-cell-carcinoma
#14
Dan Jiao, Man Wu, Lei Ji, Feng Liu, Yingying Liu
Recent evidence suggests that dysregulation of microRNAs are associated with the development of multiple malignancies.miR-186 has been reported as a critical cancer regulator in several types of cancers. However, its functional significance and molecular mechanism underlying renal cell carcinoma (RCC) remains unknown. In this study, our results showed that miR-186 expression was dramatically downregulated in RCC tissues and cell lines compared to that in adjacent normal tissues and cell lines. Overexpression of miR-186 significantly inhibited cell growth, colony formation, cell invasion, caused cell cycle arrest at G0/G1 phase, and induced cell apoptosis as detected by MTT, colony formation, Transwell assay, and flow cytometry assays in RCC cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550685/long-noncoding-rna-camta1-promotes-proliferation-and-mobility-of-human-breast-cancer-cell-line-mda-mb-231-via-targeting-mir-20b
#15
Pengwei Lu, Yuanting Gu, Lin Li, Fang Wang, Xue Yang, Yunqing Yang
Breast cancer is a serious threat to women's physical and psychological health. Long non-coding RNA CAMTA1 (LncCAMTA1)was believed to be related with tumor progression, but its role in breast cancer is not clear. Human breast cancer cell line MDA-MB-231 was used to investigate effect of LncCAMTA1 on cell viability, migration/invasion, and apoptosis. Expression of LncCAMTA1, miR-20b and VEGF in MDA-MB-231were measured after corresponding transfections. Binding effects between LncCAMTA1 and miR-20b, miR-20b and VEGF 3'UTR were measured...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550684/long-noncoding-rna-ccat2-knockdown-suppresses-tumorous-progression-by-sponging-mir-424-in-epithelial-ovarian-vancer
#16
Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Liu
Epithelial ovarian cancer (EOC) is the one of most common gynecological malignant tumor with highest mortality, meanwhile, series of lncRNAs have been validated to play vital role in EOC tumorigenesis. Colon cancer-associated transcript 2 (CCAT2) has been verified as oncogenic lncRNA in multiple tumors, however, the role of CCAT2 in EOC genesis is still unclear. The purpose of present study is to probe the function of CCAT2 on EOC. Preliminary experiments found that CCAT2 expression was significantly up-regulated in EOC tissue and cell lines compared to noncancerous tissue and cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550683/oncogenic-role-of-microrna-30b-5p-in-glioblastoma-through-targeting-proline-rich-transmembrane-protein-2
#17
Zhongjun Li, Junxiu Guo, Yujie Ma, Zhixiong Lin, Longbo Zhang
MicroRNAs (miRs) have been found to play promoting or suppressive roles in different human cancers. However, the exactregulatory mechanism of miR-30b in glioblastoma still remains unknown. Here we showed that the expression of miR-30b was significantly increased in glioblastoma tissues and cell lines. Moreover, high expression of miR-30b was significantly associated with shorter survival time of glioblastoma patients. Knockdown of miR-30b caused a significant reduction in the proliferation, migration, and invasion of U87 and A172 cells...
May 17, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550682/long-noncoding-rna-anril-promotes-cervical-cancer-development-by-acting-as-a-sponge-of-mir-186
#18
Jun-Jun Zhang, Dan-Dan Wang, Chen-Xiang Du, Yan Wang
Cervical cancer is a common malignancy of female reproductive system. Long non-coding RNA (lncRNA) has been reported tomodulate tumor progression in multiple cancers. The lncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been testified as oncogenic molecular in series tumors, however, the function and underlying mechanism involved in cervical cancer oncogenesis is still unclear. In present study, RT-PCR showed that ANRIL expression was significantly up-regulated in cervical cancer tumors and cell lines...
May 22, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550679/downregulation-of-src-kinase-signaling-inhibitor-1-srcin1-expression-by-microrna-32-promotes-proliferation-and-epithelial-mesenchymal-transition-in-human-liver-cancer-cells
#19
Ren Chen, Jin-Yao Liao, Jing Huang, Wen-Li Chen, Xiao-Jun Ma, Xiao-Dan Luo
MicroRNAs play an important role in regulating gene expression by binding to the 3' UTR of target mRNAs. In this studywe have made an attempt to assess the molecular mechanisms by which miR-32 suppresses the expression of SRCIN1, thereby leading to promotion of proliferation and epithelial-mesenchymal transition of human liver cancer cells. Human liver cancer cell lines HepG2 were transfected with miR-32 mimics and its control. The HepG2 cell lines were the assessed for miR-32 expression. The transfected cell lines were then studied for SRCIN1 expression by luciferase assay, effect of transfection on cell proliferation and finally epithelial-mesenchymal transition...
May 22, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550678/knockdown-of-long-noncoding-rna-lncrna-metastasis-associated-lung-adenocarcinoma-transcript-1-malat1-inhibits-proliferation-migration-and-invasion-and-promoted-apoptosis-by-targeting-mir-124-in-retinoblastoma
#20
Shujun Liu, Guigang Yan, Junfu Zhang, Lianzhi Yu
Evidence suggests that the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation. However, the underlying mechanisms regarding the role of MALAT1 in retinoblastoma (RB) remains unclear. This study aimed to explore the functional role of MALAT1 in RB by targeting miR-124. Results showed that the expression of - MALAT1 was significantly higher in Y79 cell line than ARPE-19 cell line (P<0...
May 21, 2017: Oncology Research
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