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mycoplasma pneumoniae

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https://www.readbyqxmd.com/read/28440917/atf3-inhibits-the-inflammation-induced-by-mycoplasma-pneumonia-in-vitro-and-in-vivo
#1
Jing Wang, Wei Cheng, Zhen Wang, Lihong Xin, Wen Zhang
OBJECTIVES: Activating transcription factor-3 (ATF3) is a key regulator of inflammatory responses. We aimed to investigate the effects and mechanisms of ATF3 on the inflammatory cytokines are induced by Mycoplasma pneumonia (MP). STUDY DESIGN: RAW264.7 and mouse peritoneal macrophages were exposed to various time with or without MP infection (3, 6, 12, 24, and 48 h), and detect the expression of ATF3. Adenovirus-expression of ATF3 (Ad/ATF3) or Ad/βgal was transfected into cells which were exposed to MP for 48 h, RT-PCR and ELISA was used to evaluate the expression and secretion of TNF-α, IL-1β, IL-6, and IL-18...
April 25, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28431520/infectious-agents-is-a-risk-factor-for-myxomatous-mitral-valve-degeneration-a-case-control-study
#2
Marcos Gradim Tiveron, Pablo Maria Alberto Pomerantzeff, Maria de Lourdes Higuchi, Marcia Martins Reis, Jaqueline de Jesus Pereira, Joyce Tieko Kawakami, Renata Nishiyama Ikegami, Carlos Manuel de Almeida Brandao, Fabio Biscegli Jatene
BACKGROUND: The etiology of myxomatous mitral valve degeneration (MVD) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. The purpose of the study is to analyze the effect of Mycoplasma pneumoniae (Mp), Chlamydophila pneumoniae (Cp) and Borrelia burgdorferi (Bb) on myxomatous mitral valve degeneration pathogenesis and establish whether increased in inflammation and collagen degradation in myxomatous mitral valve degeneration etiopathogenesis...
April 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28430965/nrf2-regulates-the-inflammatory-response-including-heme-oxygenase-1-induction-by-mycoplasma-pneumoniae-lipid-associated-membrane-proteins-in-thp-1-cells
#3
Jihong Hu, Chunyan Chen, Guangli Ou, Xiaoxing You, Tianping Tan, Xinnian Hu, Yihua Zeng, Minjun Yu, Cuiming Zhu
A series of inflammatory responses caused by Mycoplasma pneumoniae largely depend on the lipid-associated membrane proteins (LAMPs). Nuclear factor E2-related factor 2 (Nrf2), a transcription factor, is considered to be a critical modulator of inflammatory responses and cellular redox homeostasis. Monocytes play an important role in the invasion and immunity to resist pathogens. Here, we investigated the role of Nrf2 in the anti-inflammatory response stimulated by LAMPs using the human monocyte cell line THP-1...
April 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28413775/an-interesting-case-of-mycoplasma-pneumonia-associated-multisystem-involvement-and-diffuse-alveolar-hemorrhage
#4
Rashmi Mishra, Edison Cano, Sindhaghatta Venkatram, Gilda Diaz-Fuentes
Severe mycoplasma pneumonia is a rare entity with only 0.5-2% of cases having a fulminant course. We present a 74-year-old woman with hypertension, diabetes mellitus and remote history of marginal zone B-cell lymphoma admitted with abdominal pain and diarrhea of 1-2 days associated with body-aches, dyspnea, dry cough and weight loss for 2-3 weeks. On physical exam, she was febrile, tachypneic, tachycardic and hypoxic on room air. Chest examination revealed diffuse crackles and end-expiratory wheezes. Laboratory tests showed anemia, acute-on-chronic kidney injury and hyaline casts and epithelial cells in the urine analysis...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28410368/comprehensive-bioinformatics-analysis-of-mycoplasma-pneumoniae-genomes-to-investigate-underlying-population-structure-and-type-specific-determinants
#5
Maureen H Diaz, Heta P Desai, Shatavia S Morrison, Alvaro J Benitez, Bernard J Wolff, Jason Caravas, Timothy D Read, Deborah Dean, Jonas M Winchell
Mycoplasma pneumoniae is a significant cause of respiratory illness worldwide. Despite a minimal and highly conserved genome, genetic diversity within the species may impact disease. We performed whole genome sequencing (WGS) analysis of 107 M. pneumoniae isolates, including 67 newly sequenced using the Pacific BioSciences RS II and/or Illumina MiSeq sequencing platforms. Comparative genomic analysis of 107 genomes revealed >3,000 single nucleotide polymorphisms (SNPs) in total, including 520 type-specific SNPs...
2017: PloS One
https://www.readbyqxmd.com/read/28404679/evaluation-of-taqman-array-card-tac-for-the-detection-of-central-nervous-system-infections-in-kenya
#6
Clayton O Onyango, Vladimir Loparev, Shirley Lidechi, Vinod Bhullar, D Scott Schmid, Kay Radford, Michael K Lo, Paul Rota, Barbara W Johnson, Jorge Munoz, Martina Oneko, Deron Burton, Carolyn M Black, John Neatherlin, Joel M Montgomery, Barry Fields
Infections of the central nervous system (CNS) are often acute with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-Saharan Africa. We developed a TaqMan Array Card (TAC) that detects multiple pathogens simultaneously from cerebrospinal fluid (CSF). The 21-pathogen TAC assays include two parasites (Balamuthia mandrillaris and Acanthamoeba), six bacterial pathogens (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, and Bartonella) and 13 viruses (parechovirus, dengue, nipah, varicella zoster, mumps, measles, lyssa, herpes simplex virus 1 and 2, Epstein Barr virus, enterovirus, cytomegalovirus and chikungunya)...
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28403117/association-of-the-ace-gstm1-il-6-nos3-and-cyp1a1-polymorphisms-with-susceptibility-of-mycoplasma-pneumoniae-pneumonia-in-chinese-children
#7
Jie Zhao, Wen Zhang, Li Shen, Xiaomeng Yang, Yi Liu, Zhongtao Gai
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia (CAP) and the clinical presentation of mycoplasma pneumoniae pneumonia (MPP) varies widely. Genetic variability affecting the host response may also influence the susceptibility to MPP. Several studies have investigated the association between single nucleotide polymorphism (SNP) of some genes and the risks of CAP; however, the results were inconsistent. Here, we investigated the association of 5 functional genes and the risks of MPP, including ACE (rs4340), GSTM1 (Ins/del), IL-6 (rs1800795), NOS3 (rs1799983), and CYP1A1 (rs2606345) in a total of 715 subjects (415 cases, 300 controls) by using tetra-primer allele-specific polymerase chain reaction (PCR) and Sanger sequencing...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28403048/prevalence-of-mycoplasma-pneumoniae-infection-in-malagasy-children
#8
Lova Ravelomanana, Naim Bouazza, Mbola Rakotomahefa, André Zo Andrianirina, Annick Lalaina Robinson, Honoré Raobidjaona, Rabezanahary Andriamihaja, Nadjet Benhaddou, Fréderique Randrianirina, Elisoa Ratsima, Patrick Imbert, Josette Raymond
BACKGROUND: Childhood community-acquired pneumonia is a leading cause of childhood morbidity in low-income countries. The etiologic agents are usually Staphylococcus aureus, Streptococcus pneumoniae and Mycoplasma pneumoniae. M. pneumoniae was recognized as a cofactor in asthmatic disease. High asthma prevalence was reported in Madagascar. Our aim was to clarify the prevalence of M. pneumoniae infection in this country and its relationship with asthma. METHODS: A prospective study was conducted in 351 children (from 2 to 16 years of age) from January 2012 to December 2014...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28393985/-importance-of-respiratory-virus-in-immunocompetent-adult-patients-hospitalized-with-community-acquired-pneumonia
#9
Fernando Saldías Peñafiel, Marcos Ortega Gutiérrez, Gino Fuentes López, José Manuel Elola Aránguiz, Javier Uribe Monasterio, Arturo Morales Soto, Orlando Díaz Patiño
BACKGROUND: Community-acquired pneumonia (CAP) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. AIM: To assess the etiology of CAP in immunocompetent adult hospitalized patients using conventional and molecular diagnostic methods. MATERIAL AND METHODS: We prospectively studied 240 adult patients who were hospitalized for CAP to identify the microbial etiology...
December 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28393730/fatal-swine-influenza-a-h1n1-and-mycoplasma-pneumoniae-coinfection-in-a-child
#10
K Jagadishkumar Kalenahalli, N Arun Kumar, K V Ashok Chowdary, M S Sumana
One of the most common causes of death in influenza patients is secondary bacterial pneumonia and the most common pathogens involved are Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenza. To diagnose co infection with bacteria in a H1N1 case can be difficult but should be strongly suspected in a child who present with influenza like illness and lower respiratory tract signs or symptoms. We report coinfection of Mycoplasma pneumoniae in swine influenza A H1N1 child who presented with extensive pneumonia and expired within 48 hours...
September 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28389347/patho-bacteriological-investigation-of-an-outbreak-of-mycoplasma-bovis-infection-in-calves-emerging-stealth-assault
#11
Fazal Mahmood, Ahrar Khan, Riaz Hussain, Imtiaz Ahmad Khan, Rao Zahid Abbas, Hafiz Muhammad Ali, Muhammad Younus
Mycoplasma bovis (M. bovis) is an important bacterium, causing severe respiratory infection, and arthritis in dairy animals worldwide. This study is based on 50 suckling calves among which 15 showed respiratory distress, lameness and swollen joints and died later. M. bovis was isolated and identified from all dead (n = 15) and live (17.14%; 06 out of 35) calves on the basis of bacteriological examination. In morbid calves, the carpus and stifle joints were severely affected, while necropsy revealed multiple well-circumscribed calcified abscesses and caseous exudates in cranio-ventral and diaphragmatic lobes of lungs...
April 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28388953/a-randomized-controlled-study-on-the-efficacy-of-a-novel-combination-vaccine-against-enzootic-pneumonia-mycoplasma-hyopneumoniae-and-porcine-circovirus-type-2-pcv2-in-the-presence-of-strong-maternally-derived-pcv2-immunity-in-pigs
#12
Panagiotis D Tassis, Ioannis Tsakmakidis, Vassileios G Papatsiros, Dimitrios Koulialis, Tom Nell, Georgia Brellou, Eleni D Tzika
BACKGROUND: Mycoplasma hyopneumoniae (M. hyo) and Porcine Circovirus Type 2 (PCV2) are major pathogens that cause significant health problems in swine worldwide. Maternal derived immunity (MDI) has been suggested as a significant immediate defence factor for newborn piglets and may interfere with piglet's vaccination-induced immunity. The study aimed to assess the efficacy of a novel combination vaccine (consisting of PCV2 subunits and inactivated M. hyo strain J), against PCV2 and M...
April 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28380065/potential-use-of-local-and-systemic-humoral-immune-response-parameters-to-forecast-mycoplasma-hyopneumoniae-associated-lung-lesions
#13
Beatriz Garcia-Morante, Joaquim Segalés, Lorenzo Fraile, Gemma Llardén, Teresa Coll, Marina Sibila
Immunopathological events are key for the development of enzootic pneumonia (EP), which is macroscopically observed as cranioventral pulmonary consolidation (CVPC). This study aimed to investigate the putative association between the humoral immune response against Mycoplasma hyopneumoniae (M. hyopneumoniae) and prevalence and extension of CVPC in 1) experimentally infected pigs, 2) slaughtered pigs and 3) sequentially necropsied pigs in a longitudinal study. CVPC was scored by means of the European Pharmacopoeia recommended methodology...
2017: PloS One
https://www.readbyqxmd.com/read/28376442/prevalence-of-atypical-pathogens-in-patients-with-cough-and-community-acquired-pneumonia-a-meta-analysis
#14
REVIEW
Christian Marchello, Ariella Perry Dale, Thuy Nhu Thai, Duk Soo Han, Mark H Ebell
PURPOSE: Community-acquired pneumonia (CAP), acute cough, bronchitis, and lower respiratory tract infections (LRTI) are often caused by infections with viruses or Streptococcus pneumoniae. The prevalence of atypical pathogens Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis among patients with these illnesses in the ambulatory setting has not been previously summarized. We set out to derive prevalence information from the existing literature...
November 2016: Annals of Family Medicine
https://www.readbyqxmd.com/read/28373274/the-variable-internal-structure-of-the-mycoplasma-penetrans-attachment-organelle-revealed-by-biochemical-and-microscopic-analyses-implications-for-attachment-organelle-mechanism-and-evolution
#15
Steven L Distelhorst, Dominika A Jurkovic, Jian Shi, Grant J Jensen, Mitchell F Balish
Although mycoplasmas have small genomes, many of them, including the HIV-associated opportunist Mycoplasma penetrans, construct a polar attachment organelle (AO) used for both adherence to host cells and gliding motility. However, the irregular phylogenetic distribution of similar structures within the mycoplasmas as well as compositional and ultrastructural differences among these AOs suggest that AOs have arisen several times by convergent evolution. We investigated the ultrastructure and protein composition of the cytoskeleton-like material of the M...
April 3, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28366159/-fatal-swine-influenza-a-h1n1-and-mycoplasma-pneumoniae-coinfection-in-a-child
#16
K Jagadishkumar Kalenahalli, N Arun Kumar, K V Ashok Chowdary, M S Sumana
One of the most common causes of death in influenza patients is secondary bacterial pneumonia and the most common pathogens involved are Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenza. To diagnose co infection with bacteria in a H1N1 case can be difficult but should be strongly suspected in a child who present with influenza like illness and lower respiratory tract signs or symptoms. We report coinfection of Mycoplasma pneumoniae in swine influenza A H1N1 child who presented with extensive pneumonia and expired within 48 hours...
September 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28365060/clinical-evaluation-of-a-new-single-tube-multiplex-reverse-transcription-pcr-assay-for-simultaneous-detection-of-11-respiratory-viruses-mycoplasma-pneumoniae-and-chlamydia-in-hospitalized-children-with-acute-respiratory-infections
#17
Meng-Chuan Zhao, Gui-Xia Li, Dan Zhang, Hang-Yu Zhou, Hao Wang, Shuo Yang, Le Wang, Zhi-Shan Feng, Xue-Jun Ma
Respiratory Pathogen 13 Detection Kit (13× kit) is able to simultaneously detect 11 respiratory viruses, Mycoplasma pneumoniae (MP) and Chlamydia in a single reaction. Using 572 Nasopharyngeal aspirates collected from hospitalized children, the clinical performance of 13× kit for detecting 11 respiratory viruses was evaluated in comparison with a routinely used 2-tube multiplex reverse transcription PCR assay (2-tube assay) at provincial Centers for Disease Control and Prevention in China. The clinical performance of 13× kit for detecting MP and Chlamydia was evaluated by commercial real-time quantitative PCR (qPCR) kits or sequencing...
March 22, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28337456/comparison-of-the-protective-effects-of-individual-components-of-particulated-trans-sialidase-ptcts-ptc-and-ts-against-high-cholesterol-diet-induced-atherosclerosis-in-rabbits
#18
Shérrira M Garavelo, Maria de Lourdes Higuchi, Jaqueline J Pereira, Marcia M Reis, Joyce T Kawakami, Renata N Ikegami, Suely A P Palomino, Nilsa S Y Wadt, Abdelali Agouni
Previous studies showed the presence of Mycoplasma pneumoniae (M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural particles from medicinal plants (PTC) combined with trans-Sialidase (TS), to combat MPs and Mycoplasma pneumoniae. Our aim was to determine the effects of the different components of PTCTS in a rabbit model of atherosclerosis. Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28336122/familial-acute-necrotizing-encephalopathy-with-ranbp2-mutation-the-first-report-in-northeast-asia
#19
Yun-Jeong Lee, Su-Kyeong Hwang, So Mi Lee, Soonhak Kwon
BACKGROUND: Acute necrotizing encephalopathy (ANE) is a rare but rapidly progressing encephalopathy following a febrile illness, commonly a viral infection. It is characterized by the features of acute encephalopathy such as seizure, alteration of consciousness, and symmetric involvement of the bilateral thalamus on neuroimaging tests. Although most ANE cases have occurred sporadically, familial or recurrent ANE has been reported in Caucasian patients, with genetic susceptibility to ANE noted in some patients due to a RANBP2 mutation...
March 20, 2017: Brain & Development
https://www.readbyqxmd.com/read/28324273/acute-pancreatitis-caused-by-mycoplasma-pneumoniae-an-unusual-etiology
#20
Teresa Valdés Lacasa, María Alejandra Duarte Borges, Alicia García Marín, Covadonga Gómez Cuervo
It is well known that the most important etiologies of acute pancreatitis are gallstones and alcohol consumption. Once these causes have been ruled out, especially in young adults, it is important to consider less frequent etiologic factors such as drugs, trauma, malformations, autoimmunity or systemic diseases. Other rare and less well studied causes of this pathology are infections, among which Mycoplasma pneumoniae has been reported to cause acute pancreatitis as an unusual extrapulmonary manifestation. Here, we report the case of a 21-year-old patient who had acute idiopathic pancreatitis associated with an upper respiratory tract infection...
March 21, 2017: Clinical Journal of Gastroenterology
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