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mycoplasma pneumoniae

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https://www.readbyqxmd.com/read/29904437/-mycoplasma-pneumoniae-a-potentially-severe-infection
#1
REVIEW
Bharat Bajantri, Sindhaghatta Venkatram, Gilda Diaz-Fuentes
Mycoplasma pneumoniae infections remain one of the most common etiologies of community-acquired pneumonia (CAP). The clinical presentation and manifestations vary widely and can affect all organs of the body. Diagnosis is challenging because there are no constant findings in physical exams or laboratory or radiological assessments that indicate Mycoplasma pneumoniae pneumonia, and specific diagnostic tools are not readily available. Extrapulmonary manifestations and severe pulmonary manifestations can lead to long-term sequelae...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29902131/a-survey-of-bacterial-respiratory-pathogens-in-native-and-introduced-mountain-goats-oreamnos-americanus
#2
Blake Lowrey, Carson J Butler, William H Edwards, Mary E Wood, Sarah R Dewey, Gary L Fralick, Jessica Jennings-Gaines, Halcyon Killion, Douglas E McWhirter, Hollie M Miyasaki, Shawn T Stewart, Kevin S White, Patrick J White, Robert A Garrott
In contrast to broad range expansion through translocations, many mountain goat ( Oreamnos americanus) populations have shown signs of decline. Recent documentation of pneumonia in mountain goats highlights their susceptibility to bacterial pathogens typically associated with bighorn sheep ( Ovis canadensis) epizootics. Respiratory pathogen communities of mountain goats are poorly characterized yet have important implications for management and conservation of both species. We characterized resident pathogen communities across a range of mountain goat populations as an initial step to inform management efforts...
June 14, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29899785/association-between-posterior-reversible-encephalopathy-syndrome-and-mycoplasma-pneumoniae-infection
#3
Archana Ramgopal, Aravind Thavamani, Abdulla Ghori
Mycoplasma pneumoniae is a microbe known to affect numerous organ systems, and in particular, can cause neurological manifestations. We describe an otherwise healthy child who presented with acute onset intractable headache with magnetic resonance imaging (MRI) findings consistent with posterior reversible encephalopathy syndrome (PRES), a neurological manifestation that presents with headache, vision changes, altered mental status, or seizures. Our patient did not have any of the common etiologies for PRES reported but tested positive for acute M...
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29891509/raised-intracranial-pressure-with-bilateral-anterior-uveitis
#4
Ivan Yeu Ming Yip, Stephen Scotcher
We report the rare case of a 5-year-old boy with an infective cause of papilloedema and bilateral uveitis secondary to Mycoplasma pneumoniae The patient presented with generalised headache and malaise. MRI showed signs of raised intracranial pressure and lumbar puncture opening pressure was 43 cmH2 O.Lumbar puncture did not reveal any infective organisms. Blood tests showed raised inflammatory markers. The patient was started on prednisolone, acetazolamide and intravenous cefotaxime. Following an improvement, the patient was discharged...
June 10, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29891193/the-mpn668-gene-of-mycoplasma-pneumoniae-encodes-a-novel-organic-hydroperoxide-resistance-protein
#5
Lie-Song Chen, Chun Li, Xiao-Xing You, Ying-Wu Lin, Yi-Mou Wu
Mycoplasma pneumoniae (M. pneumoniae), as an obligate parasite, has evolved a protective strategy for coping with oxidative challenges caused by M. pneumoniae itself as well as the host immune system. However, to date, few antioxidant enzymes have been identified in mycoplasmas. In this report, we identified a protein encoded by the mpn668 gene from M. pneumoniae with a putative function as an organic hydroperoxide reductase (Ohr). The results indicated that the recombinant 140 amino acid protein, designated rMPN668, displayed hydroperoxidase activity towards both organic (tert-butyl hydroperoxide) and inorganic (hydrogen peroxide) hydroperoxides in the presence of a reducing agent such as dithiothreitol...
May 30, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29889810/pathogen-clearance-and-new-respiratory-tract-infections-among-febrile-children-in-zanzibar-investigated-with-multitargeting-real-time-polymerase-chain-reaction-on-paired-nasopharyngeal-swab-samples
#6
Kristina Elfving, Deler Shakely, Maria Andersson, Kimberly Baltzell, Mwinyi I Msellem, Anders Björkman, Andreas Mårtensson, Max Petzold, Birger Trollfors, Magnus Lindh
BACKGROUND: New molecular methods have revealed frequent and often polymicrobial respiratory infections in children in low-income settings. It is not known whether presence of multiple pathogens is due to prolonged infections or to frequent exposure. The aim of this study was to analyze short-term pathogen clearance from nasopharynx and the rate of new respiratory tract infections in febrile preschool children. METHODS: Children (n = 207) with uncomplicated acute febrile illness 2-59 months of age presenting to a health center in Zanzibar, Tanzania, April-July 2011, were included...
July 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29885004/sialylated-receptor-setting-influences-mycoplasma-pneumoniae-attachment-and-gliding-motility
#7
Caitlin R Williams, Li Chen, Ashley D Driver, Edward A Arnold, Edward S Sheppard, Jason Locklin, Duncan C Krause
Mycoplasma pneumoniae is a common cause of human respiratory tract infections, including bronchitis and atypical pneumonia. M. pneumoniae binds glycoprotein receptors having terminal sialic acid residues via the P1 adhesin protein. Here we explored the impact of sialic acid presentation on M. pneumoniae adherence and gliding on surfaces coated with sialylated glycoproteins, or chemically functionalized with α-2,3- and α-2,6-sialyllactose ligated individually or in combination to a polymer scaffold in precisely controlled densities...
June 8, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29880620/lipsch%C3%A3-tz-ulcer-and-group-a-streptococcal-tonsillitis
#8
Sara Limão, Ana Ventura, Gustavo Queirós, Florbela Cunha
Lipschütz ulcers (LU) are non-sexually related genital ulcers, rarely reported. We describe a healthy 11-year-old girl, who presented with fever and a painful vulvar ulcer associated with erythematous tonsillitis. Throat swab test for Group A Streptococcus (GAS) was positive. She was treated with amoxicillin. Further investigation was negative, including Herpes Simplex virus DNA from ulcer swab and serology for Epstein-Barr virus, cytomegalovirus and Mycoplasma pneumoniae Antistreptolysin O titre was high...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29874388/laboratory-diagnosis-of-mycoplasma-pneumoniae-infections-data-analysis-from-clinical-practice
#9
Francesca Montagnani, Barbara Rossetti, Alessandro Vannoni, Maria Grazia Cusi, Andrea De Luca
An etiological diagnosis of respiratory infections caused by Mycoplasma pneumoniae is particularly challenging due to the lack of a definite standard test. This study aimed to analyse the correlation and combination of diagnostic results obtained from direct and indirect assays (Mycoplasma pneumoniae DNA by PCR and serology) in use at a first level diagnostic laboratory. Samples from patients with respiratory infections tested for M. pneumoniae during routine clinical practice were retrospectively analysed...
June 6, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29864383/probable-epidemic-mycoplasma-pneumoniae-disease-activity-in-metropolitan-sydney-2015-combining-surveillance-data-to-cross-validate-signal-detection
#10
Philip N Britton, Shopna Kumari Bag, Robert Booy, Caroline Sharpe, Katherine Bridget Owen, Jiaying Zhao, Melissa Jane Irwin, Cheryl Jones
Mycoplasma pneumoniae is a leading cause of encephalitis and pneumonia in children. Active surveillance identified a cluster of children with suspected encephalitis associated with M.pneumoniae in NSW during July, 2015. An investigation that cross validated encephalitis surveillance with ED pneumonia surveillance and senitenal reference laboratory data revealed probable epidemic M.pneumoniae disease activity in Sydney during 2015.
December 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29849498/the-protective-effect-of-naringenin-on-airway-remodeling-after-mycoplasma-pneumoniae-infection-by-inhibiting-autophagy-mediated-lung-inflammation-and-fibrosis
#11
Yan Lin, Dan Tan, Qianna Kan, Zhen Xiao, Zhiyan Jiang
Our previous study has shown that Chinese medicine, Qingfei Tongluo formula (QTF), has a significantly therapeutic effect to Mycoplasma pneumoniae (MP) pneumonia (MPP). The aim of this study was to investigate the therapeutic effect and mechanism of naringenin (NRG) on MPP which was an important component of QTF. Here, we studied 124 children with or without MPP and compared inflammatory cytokines and fibrinogen-related protein expression with enzyme-linked immunosorbent assay. We also employed a BALB/c mouse model of MPP and divided the mice into three groups: ctrl (normal control mice), MPP (MP - infected mice), and MPP + NRG (MP - infected mice treated with NRG)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29845357/serological-diagnosis-of-mycoplasma-pneumoniae-infection-by-using-the-mimic-epitopes
#12
Wenyuan Shi, Lanhua Zhao, Shengtao Li, Guizhen Xu, Yanhua Zeng
Nowadays, there is lack of effective serological detection method for Mycoplasma pneumoniae (M. pneumoniae) infection in clinic. In this study, the mimic epitopes of M. pneumoniae were screened to evaluate the role in the serodiagnosis of M. pneumoniae infection. The M. pneumoniae-positive serum was used as the target for biopanning to phage display random 7-peptide library. The positive phage clones were selected and the DNA were sequenced and analyzed by BLAST. The representative phages were identified using dot immunoblotting and ELISA...
May 29, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29790844/antibiotic-use-for-community-acquired-pneumonia-in-neonates-and-children-who-evidence-review
#13
Shrey Mathur, Aline Fuchs, Julia Bielicki, Johannes Van Den Anker, Mike Sharland
Background Pneumonia is the most common cause of death in children worldwide, accounting for 15% of all deaths of children under 5 years of age. This review summarises the evidence for the empirical antibiotic treatment of community-acquired pneumonia in neonates and children and puts emphasis on publications since the release of the previous WHO Evidence Summary report published in 2014. Methods A systematic search for systematic reviews and meta-analyses of antibiotic therapy for community-acquired pneumonia was conducted between 1 January 2013 and 10 November 2016...
November 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29789582/the-concordance-between-upper-and-lower-respiratory-microbiota-in-children-with-mycoplasma-pneumoniae-pneumonia
#14
Wenkui Dai, Heping Wang, Qian Zhou, Xin Feng, Zhiwei Lu, Dongfang Li, Zhenyu Yang, Yanhong Liu, Yinhu Li, Gan Xie, Kunling Shen, Yonghong Yang, Yuejie Zheng, Shuaicheng Li
In recent years, the morbidity of Mycoplasma pneumoniae pneumonia (MPP) has dramatically increased in China. An increasing number of studies indicate that an imbalance in the respiratory microbiota is associated with respiratory infection. We selected 28 hospitalized patients infected with M. pneumoniae and 32 healthy children. Nasopharyngeal (NP) and oropharyngeal (OP) swabs were collected from healthy children, whereas NP, OP and bronchoalveolar lavage (BAL) specimens were collected from patients. Microbiota analysis was performed on all microbial samples using 16 S ribosomal RNA (16 S rRNA) sequencing...
May 23, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29788200/mycoplasma-pneumoniae-as-a-cause-of-community-acquired-pneumonia-in-children
#15
Samir S Shah
No abstract text is available yet for this article.
May 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29788037/mycoplasma-pneumoniae-among-children-hospitalized-with-community-acquired-pneumonia
#16
Preeta K Kutty, Seema Jain, Thomas H Taylor, Anna M Bramley, Maureen H Diaz, Krow Ampofo, Sandra R Arnold, Derek J Williams, Kathryn M Edwards, Jonathan A McCullers, Andrew T Pavia, Jonas M Winchell, Stephanie J Schrag, Lauri A Hicks
Background: The burden and epidemiology of Mycoplasma pneumoniae (Mp) among U.S. children (<18 years) hospitalized with community-acquired pneumonia (CAP) are poorly understood. Methods: In the Etiology of Pneumonia in the Community (EPIC) study, we prospectively enrolled 2254 children hospitalized with radiographically-confirmed pneumonia from January 2010-June 2012 and tested nasopharyngeal/oropharyngeal swabs for Mp using real-time polymerase chain reaction (PCR)...
May 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29786424/tuning-gene-activity-by-inducible-and-targeted-regulation-of-gene-expression-in-minimal-bacterial-cells
#17
Ana M Mariscal, Shigeyuki Kakizawa, Jonathan Y Hsu, Kazuki Tanaka, Luis González-González, Alicia Broto, Enrique Querol, Maria Lluch-Senar, Carlos Piñero-Lambea, Lijie Sun, Philip D Weyman, Kim S Wise, Chuck Merryman, Gavin Tse, Adam J Moore, Clyde A Hutchison, Hamilton O Smith, Masaru Tomita, J Craig Venter, John I Glass, Jaume Piñol, Yo Suzuki
Functional genomics studies in minimal mycoplasma cells enable unobstructed access to some of the most fundamental processes in biology. Conventional transposon bombardment and gene knockout approaches often fail to reveal functions of genes that are essential for viability, where lethality precludes phenotypic characterization. Conditional inactivation of genes is effective for characterizing functions central to cell growth and division, but tools are limited for this purpose in mycoplasmas. Here we demonstrate systems for inducible repression of gene expression based on clustered regularly interspaced short palindromic repeats-mediated interference (CRISPRi) in Mycoplasma pneumoniae and synthetic Mycoplasma mycoides, two organisms with reduced genomes actively used in systems biology studies...
May 22, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29785832/lectin-microarray-combined-with-mass-spectrometry-identifies-haptoglobin-related-protein-hpr-as-a-potential-serologic-biomarker-for-separating-non-bacterial-pneumonia-from-bacterial-pneumonia-in-childhood
#18
Lin Yang, Zhou Yang, Lei Cheng, Juan Cheng, Li Cheng, Yangyang Sun, Wenting Li, Kai Song, Weichun Huang, Yong Yin, Shengce Tao, Qinghua Zhang
PURPOSE: Etiological diagnosis of pediatric patients with community-acquired pneumonia is difficult. For therapy, one of the major problems is the difficulty in separating bacterial pneumonia which would benefit from antibiotics from non-bacterial pneumonia. Therefore, we sought to identify potential biomarkers for distinguishing non-bacterial pneumonia from bacterial pneumonia. EXPERIMENTAL DESIGN: Lectin microarray containing 91 lectins was used to screen serums from pediatric patients with pneumonia...
May 22, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29783968/investigating-porcine-parvoviruses-genogroup-2-infection-using-in-situ-polymerase-chain-reaction
#19
Dinko Novosel, Daniel Cadar, Tamás Tuboly, Andreja Jungic, Tomasz Stadejek, Tahar Ait-Ali, Attila Cságola
BACKGROUND: Porcine parvovirus 2 (PPV2) was detected in swine serum without showing any relationship with disease. The emergence of the virus seemed to be a unique event until other genetically highly similar parvoviruses were identified in China and, later in 2012, the presence of the virus was also described in Europe. PPV2 is widely distributed in pig populations where it is suspected to be involved in respiratory conditions, based on its frequent detection in lung samples. In order to investigate the potential pathogenic involvement of PPV2, 60 dead pigs were examined from two farms...
May 21, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29783820/-efficacy-of-bronchoalveolar-lavage-and-its-influence-factors-in-the-treatment-of-mycoplasma-pneumoniae-pneumonia-with-atelectasis
#20
M Yang, D H Yang, X Yang, Y S Wang, L Wu, Z M Chen
Objective: To investigate the efficacy of bronchoalveolar lavage (BAL) and its influence factors in the treatment of Mycoplasma pneumoniae pneumonia (MPP) with atelectasis. Methods: A retrospective case control study was performed on hospitalized MPP patients with atelectasis and received BAL in the Department of Pulmonology, Children's Hospital Zhejiang University School of Medicine from January 1, 2015 to July 31, 2017. Fever relieved in 48 hours and chest imaging improved in one week after BAL were considered effective...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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