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https://www.readbyqxmd.com/read/29033927/editorial-mycoplasma-pneumoniae-clinical-manifestations-microbiology-and-immunology
#1
EDITORIAL
Ran Nir-Paz, Takeshi Saraya, Takashi Shimizu, Annemarie Van Rossum, Cécile Bébéar
No abstract text is available yet for this article.
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29028977/evolving-understanding-of-the-causes-of-pneumonia-in-adults-with-special-attention-to-the-role-of-pneumococcus
#2
Daniel M Musher, Michael S Abers, John G Bartlett
Before 1945, Streptococcus pneumoniae caused more than 90% of cases of pneumonia in adults. After 1950, the proportion of pneumonia caused by pneumococcus began to decline. Pneumococcus has continued to decline; at present, this organism is identified in fewer than fewer10%-15% of cases. This proportion is higher in Europe, a finding likely related to differences in vaccination practices and smoking. Gram-negative bacilli, Staphylococcus aureus, Chlamydia, Mycoplasma, and Legionella are each identified in 2%-5% of patients with pneumonia who require hospitalization...
September 27, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29021577/interleukin-17a-as-a-good-predictor-of-the-severity-of-mycoplasma-pneumoniae-pneumonia-in-children
#3
Mingyue Yang, Fanzheng Meng, Kuo Wang, Man Gao, Ruihua Lu, Mengyao Li, Fangxing Zhao, Lijuan Huang, Yining Zhang, Genhong Cheng, Xiaosong Wang
Early distinction between severe Mycoplasma pneumoniae pneumonia (MPP) and mild MPP is still difficult. The aim of this study was to analyze cytokines in bronchoalveolar lavage fluid (BALF) and explore predicting factors of severe MPP in children. Retrospective analysis was performed on 150 children with MPP or bronchial foreign body (FB) admitted in our hospital. The mRNA levels of IL17A were found significantly lower in severe MPP group comparing with mild MPP group or FB group. However, no significant difference was found in the levels of IL4, IL10 or interferon beta1 (IFNβ1) between the two groups...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021189/presence-of-atopy-increases-the-risk-of-asthma-relapse
#4
Laurel Teoh, Ian M Mackay, Peter P Van Asperen, Jason P Acworth, Mark Hurwitz, John W Upham, Weng Hou Siew, Claire Y T Wang, Theo P Sloots, Teresa Neeman, Anne B Chang
OBJECTIVES: To describe the point prevalence of respiratory viruses/atypical bacteria using PCR and evaluate the impact of respiratory viruses/atypical bacteria and atopy on acute severity and clinical recovery in children with hospitalised and non-hospitalised asthma exacerbations. DESIGN: This was a prospective study performed during 2009-2011. SETTING: The study was performed in the emergency departments of two hospitals. PATIENTS: 244 children aged 2-16 years presenting with acute asthma to the emergency departments were recruited...
October 11, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29020161/comparison-of-efficacy-of-antimicrobial-agents-among-hospitalized-patients-with-mycoplasma-pneumoniae-pneumonia-in-japan-during-large-epidemics-of-macrolide-resistant-m-pneumoniae-infections-a-nationwide-observational-study
#5
Masato Tashiro, Kiyohide Fushimi, Kei Kawano, Takahiro Takazono, Tomomi Saijo, Kazuko Yamamoto, Shintaro Kurihara, Yoshifumi Imamura, Taiga Miyazaki, Katsunori Yanagihara, Hiroshi Mukae, Koichi Izumikawa
Background: Mycoplasma pneumoniae strains with resistance to macrolides have been spreading worldwide. This study aimed to clarify which antimicrobial agent is a better treatment for patients with M. pneumoniae pneumonia in a setting with large epidemics of macrolide-resistance. Methods: Adult patients hospitalized with laboratory-confirmed M. pneumoniae pneumonia from 2010 to 2013 were identified from the Diagnosis Procedure Combination database, a national database in Japan...
August 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018819/the-clinical-significance-of-filmarray-respiratory-panel-in-diagnosing-community-acquired-pneumonia
#6
Huanzhu Chen, Huilan Weng, Meirui Lin, Ping He, Yazhen Li, Qingdong Xie, Changwen Ke, Xiaoyang Jiao
AIM: FilmArray Respiratory Panel (FilmArray RP) test is an emerging diagnostic method in fast detecting multiple respiratory pathogens; the methodology and clinical significance of FilmArray RP in community-acquired pneumonia (CAP) diagnosis were evaluated in this study. METHODS: Specimens from 74 patients with CAP were analyzed and compared using FilmArray RP, traditional multiple PCR assay, bacterial (or fungal) culture, and serological detection. RESULTS: FilmArray RP and multiplex PCR showed 100% coincidence rate in detecting coronaviruses 229E, OC43, HKU1, and NL63, human metapneumovirus, influenza A and B, and parainfluenza viruses (PIV1, PIV2, and PIV4)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29016299/detection-of-mycoplasma-pneumoniae-and-legionella-pneumophila-in-patients-having-community-acquired-pneumonia-a-multicentric-study-from-new-delhi-india
#7
Rama Chaudhry, Arvind Valavane, K Sreenath, Mamta Choudhry, Tanu Sagar, Trupti Shende, M Varma, Srujana Mohanty, S K Kabra, A B Dey, Bhaskar Thakur
Atypical pathogens including Mycoplasma pneumoniae and Legionella pneumophila are increasingly recognized as important causes of community-acquired pneumonia (CAP). Mycoplasma pneumoniae accounts for 20-40% of all CAP and L. pneumophila is responsible for 3-15% of cases. The paucity of data from India in this regard prompted us to conduct this prospective multi centric analysis to detect the prevalence of M. pneumoniae and L. pneumophila in our geographical region. A total of 453 patients with symptoms of pneumonia and 90 controls with no history of lower respiratory tract infections were included in the study...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28984229/development-of-macrolide-resistance-associated-mutations-after-macrolide-treatment-in-children-infected-with-mycoplasma-pneumoniae
#8
Yu Suzuki, Yoshitaka Shimotai, Tsutomu Itagaki, Junji Seto, Tatsuya Ikeda, Kazue Yahagi, Katsumi Mizuta, Seiji Hongo, Yoko Matsuzaki
PURPOSE: To determine the timing of the emergence of macrolide-resistant mutations after macrolide treatment in individuals with Mycoplasma pneumoniae infections. METHODOLOGY: Between October 2011 and December 2013, serial pharyngeal swab specimens were collected before and after macrolide treatment from 21 otherwise healthy children infected with M. pneumoniae without macrolide-resistant mutations. The copy numbers of a M. pneumoniae gene and the proportion of clones showing macrolide-resistance mutations were determined for each specimen...
October 6, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28981235/-lower-respiratory-tract-infections-in-immunocompetent-adult
#9
F Jacobs
Lower respiratory tract infections represent one of the main causes of mortality in the world. They essentially consist of bronchitis, acute exacerbations of chronic obstructive bronchopulmonary diseases (COPD) and acute pneumonia. If acute bronchitis is mainly of viral origin, acute exacerbations of COPD and pneumonia are mainly due to a trio of bacteria (Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis). Other pathogens as many viruses and atypical bacteria such as Mycoplasma pneumoniae, Legionella, some Enterobacteriaceae and very rarely Pseudomonas aeruginosa are also implicated...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28977025/correction-comprehensive-bioinformatics-analysis-of-mycoplasma-pneumoniae-genomes-to-investigate-underlying-population-structure-and-type-specific-determinants
#10
Maureen H Diaz, Heta P Desai, Shatavia S Morrison, Alvaro J Benitez, Bernard J Wolff, Jason Caravas, Timothy D Read, Deborah Dean, Jonas M Winchell
[This corrects the article DOI: 10.1371/journal.pone.0174701.].
2017: PloS One
https://www.readbyqxmd.com/read/28976562/seroprevalence-of-lymphocytic-choriomeningitis-virus-and-ljungan-virus-in-finnish-patients-with-suspected-neurological-infections
#11
Cristina Fevola, Suvi Kuivanen, Teemu Smura, Antti Vaheri, Hannimari Kallio-Kokko, Heidi C Hauffe, Olli Vapalahti, Anne J Jääskeläinen
BACKGROUND: Directly-transmitted rodent-borne zoonotic viruses, such as lymphocytic choriomeningitis virus (LCMV) can cause nervous system infections. Rodent-borne Ljungan virus (LV) is considered potentially zoonotic possibly causing neurological symptoms. Our objective was to understand the role of these two viruses compared to other pathogens in causing neurological infections in Finnish patients. METHODS: Routine screening data were available for 400 patients aged 5-50 years, collected from December 2013-December 2014 with suspected neurological infection...
October 4, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28975629/etiology-of-community-acquired-pneumonia-in-1500-hospitalized-children
#12
Oumei Hao, Xuefeng Wang, Jianping Liu, Kunling Shen, Rong Ma, Zhenze Cui, Li Deng, Huimin Yan, Lining Wang, Zhaolan Liu, Xinmin Li, Hua Xu, Zhiyan Jiang, Yanning Li, Yan Huang, Baoqing Zhang, Xiaochun Feng, Chunhui He, Yonghong Jiang, Xue Zhao, Wei Wei, Zi Wang
Childhood community-acquired pneumonia (CAP) is a common illness; however, comprehensive studies of hospitalizations for CAP among children in China based on prospective and multicenter data collection are limited. The aim of this investigation was to determine the respiratory pathogens responsible for CAP in hospitalized children. From January to December 2015, oropharyngeal swabs and blood serum were collected from hospitalized children with CAP symptoms ranging in age from 6 months to 14 years at 10 hospitals across China...
October 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28962100/pediatric-clinical-features-of-mycoplasma-pneumoniae-infection-are-associated-with-bacterial-p1-genotype
#13
Liping Fan, Dong Li, Liqiong Zhang, Chuangli Hao, Huiquan Sun, Xuejun Shao, Jun Xu, Zhengrong Chen
The present study evaluated the association between different Mycoplasma pneumoniae (M. pneumonia) genotypes and clinical features of pediatric patients. Subjects were children diagnosed with community-acquired pneumonia at the Children's Hospital of Soochow University (Suzhou, China) from January 2012 to December 2013. Clinical and laboratory tests were conducted and clinical samples positive for M. pneumoniae were genotyped by nested-multiplex polymerase chain reaction. Three type I strains and three type II strains were also randomly selected for sequencing...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28961963/glycerol-metabolism-and-its-implication-in-virulence-in-mycoplasma
#14
Cedric Blötz, Jörg Stülke
Glycerol and glycerol-containing compounds such as lipids belong to the most abundant organic compounds that may serve as nutrient for many bacteria. For the cell wall-less bacteria of the genus Mycoplasma, glycerol derived from phospholipids of their human or animal hosts is the major source of carbon and energy. The lipids are first degraded by lipases, and the resulting glycerophosphodiesters are transported into the cell and cleaved to release glycerol-3-phosphate. Alternatively, free glycerol can be transported, and then become phosphorylated...
September 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28959692/bullous-skin-manifestations-of-mycoplasma-pneumoniae-infection-a-case-series
#15
Senthil Velan Bhoopalan, Vonita Chawla, Mary Beth Hogan, Nevin W Wilson, Samrat U Das
Bullous skin lesions are uncommon in children. While it is well known that Mycoplasma infections are associated with papular skin manifestations, bullous skin lesions are not commonly reported. Mycoplasma pneumoniae is a very common bacterial pathogen causing respiratory tract infection in children and adults. We report 2 children with serology-confirmed Mycoplasma infection who were hospitalized for blistering skin lesions. Both of our patients responded well to corticosteroids and one of them required intravenous immunoglobulin...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28951197/clinical-presentation-of-legionella-pneumonia-evaluation-of-clinical-scoring-systems-and-therapeutic-efficacy
#16
Naoyuki Miyashita, Futoshi Higa, Yosuke Aoki, Toshiaki Kikuchi, Masafumi Seki, Kazuhiro Tateda, Nobuko Maki, Kazuhiro Uchino, Kazuhiko Ogasawara, Hiroshi Kiyota, Akira Watanabe
To evaluate scoring systems to predict Legionella pneumonia and therapeutic efficacy against Legionella pneumonia, the Japanese Society of Chemotherapy Legionella committee has collected data on cases of Legionella pneumonia from throughout Japan. We analyzed 176 patients with Legionella pneumonia and compared them with 217 patients with Streptococcus pneumoniae pneumonia and 202 patients with Mycoplasma pneumoniae pneumonia. We evaluated four scoring systems, the Winthrop-University Hospital score, Community-Based Pneumonia Incidence Study Group score, and Japan Respiratory Society score, but they demonstrated limited sensitivity and specificity for predicting Legionella pneumonia...
September 23, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28948376/genetic-diversity-and-macrolide-resistance-of-mycoplasma-pneumoniae-isolates-from-two-consecutive-epidemics-in-slovenia
#17
R Kogoj, M Praprotnik, T Mrvič, M Korva, D Keše
Two nationwide Mycoplasma pneumoniae epidemics occurred in Slovenia between 2006 and 2016. The aim of this study was to assess which M. pneumoniae genotypes were present in our area during the selected timeframe, whether the origin of the epidemics was monoclonal or polyclonal and whether the proportion between detected genotypes changed over time. We were also interested in the presence of macrolide resistance (MR) and whether it could be linked to specific genotypes. We performed pyrosequencing of the P1 gene and multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA) typing from 872 M...
September 26, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28943541/the-correlation-between-chest-x-ray-scores-and-the-clinical-findings-in-children-and-adults-with-mycoplasma-pneumoniae-pneumonia
#18
Takeshi Saraya, Takayasu Watanabe, Yayoi Tsukahara, Kosuke Ohkuma, Haruyuki Ishii, Hirokazu Kimura, Kunimasa Yan, Hajime Goto, Hajime Takizawa
Objective To compare the radiological and laboratory data of children and adults with Mycoplasma pneumoniae pneumonia (MPP) and to evaluate the correlation between the total affected lung area and the clinical findings. Methods We retrospectively examined the data from MPP patients who visited our hospital during the period from April 2006 to July 2014. All data were retrieved at the time of the diagnosis of MPP and were analyzed to investigate the correlation between the clinical findings and the total affected lung area using a chest X-ray scoring system...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28935747/complete-genome-sequence-of-mycoplasma-hyopneumoniae-strain-km014-a-clinical-isolate-from-south-korea
#19
Jemin Han, Byung-Sun Park, Dong-Ju Shin, Soo-Yeol Song, Young-Ju Jeong, Nakhyung Lee
Mycoplasma hyopneumoniae is the etiological agent of swine enzootic pneumonia, resulting in considerable economic losses in the swine industry. A few genome sequences of M. hyopneumoniae have been reported to date, implying that additional genome data are needed for further genetic studies. Here, we present the annotated genome sequence of M. hyopneumoniae strain KM014.
September 21, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28930847/guillain-barr%C3%A3-like-axonal-polyneuropathy-associated-with-toscana-virus-infection-a-case-report
#20
Eugenia Rota, Nicola Morelli, Paolo Immovilli, Paola De Mitri, Donata Guidetti
RATIONALE: Numerous cases of post-infectious Guillain-Barré syndrome (GBS) have been reported in the literature. Toscana virus (TOSV) is an arthropod-borne emerging pathogen in the Mediterranean area. PATIENT CONCERNS: A 40-year-old male patient was admitted to hospital for acute facial weakness, associated to numbness paraesthesias at lower and upper limbs. The neurological examination revealed facial diplegia and reduced tendon reflexes. The nerve conduction studies documented an acute motor and sensory axonal neuropathy (AMSAN); the lumbar puncture detected albuminocytologic dissociation...
September 2017: Medicine (Baltimore)
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