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mycoplasma pneumoniae

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https://www.readbyqxmd.com/read/28337456/comparison-of-the-protective-effects-of-individual-components-of-particulated-trans-sialidase-ptcts-ptc-and-ts-against-high-cholesterol-diet-induced-atherosclerosis-in-rabbits
#1
Shérrira M Garavelo, Maria de Lourdes Higuchi, Jaqueline J Pereira, Marcia M Reis, Joyce T Kawakami, Renata N Ikegami, Suely A P Palomino, Nilsa S Y Wadt, Abdelali Agouni
Previous studies showed the presence of Mycoplasma pneumoniae (M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural particles from medicinal plants (PTC) combined with trans-Sialidase (TS), to combat MPs and Mycoplasma pneumoniae. Our aim was to determine the effects of the different components of PTCTS in a rabbit model of atherosclerosis. Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28336122/familial-acute-necrotizing-encephalopathy-with-ranbp2-mutation-the-first-report-in-northeast-asia
#2
Yun-Jeong Lee, Su-Kyeong Hwang, So Mi Lee, Soonhak Kwon
BACKGROUND: Acute necrotizing encephalopathy (ANE) is a rare but rapidly progressing encephalopathy following a febrile illness, commonly a viral infection. It is characterized by the features of acute encephalopathy such as seizure, alteration of consciousness, and symmetric involvement of the bilateral thalamus on neuroimaging tests. Although most ANE cases have occurred sporadically, familial or recurrent ANE has been reported in Caucasian patients, with genetic susceptibility to ANE noted in some patients due to a RANBP2 mutation...
March 20, 2017: Brain & Development
https://www.readbyqxmd.com/read/28324273/acute-pancreatitis-caused-by-mycoplasma-pneumoniae-an-unusual-etiology
#3
Teresa Valdés Lacasa, María Alejandra Duarte Borges, Alicia García Marín, Covadonga Gómez Cuervo
It is well known that the most important etiologies of acute pancreatitis are gallstones and alcohol consumption. Once these causes have been ruled out, especially in young adults, it is important to consider less frequent etiologic factors such as drugs, trauma, malformations, autoimmunity or systemic diseases. Other rare and less well studied causes of this pathology are infections, among which Mycoplasma pneumoniae has been reported to cause acute pancreatitis as an unusual extrapulmonary manifestation. Here, we report the case of a 21-year-old patient who had acute idiopathic pancreatitis associated with an upper respiratory tract infection...
March 21, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28321515/isolated-optic-neuritis-associated-with-mycoplasma-pneumoniae-infection-report-of-two-cases-and-literature-review
#4
Seo-Young Choi, You-Jin Choi, Jae-Hwan Choi, Kwang-Dong Choi
Mycoplasma pneumonia is a major pathogen of primary atypical pneumonia and has been known to cause various kinds of extrapulmonary manifestations involving almost all organs of the human body. Optic neuritis associated with M. pneumoniae infection has rarely been described and mostly, it combined other neurological complications including meningitis, meningoencephalitis, myelitis, and peripheral neuropathy. We report two patients who presented with isolated optic neuritis due to M. pneumoniae infection, and reviewed the literatures on five additional patients...
March 20, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28318608/multi-center-evaluation-of-one-commercial-and-12-in-house-real-time-pcr-assays-for-detection-of-mycoplasma-pneumoniae
#5
Roger Dumke, Alvaro J Benitez, Victoria Chalker, Karolina Gullsby, Birgit Henrich, Carlos Hidalgo-Grass, Theo Hoogenboezem, Darja Kese, Katherine Loens, Jolanda Maaskant, Ayelet Michael-Gayego, Allon E Moses, Ran Nir-Paz, Suzan D Pas, Sabine Pereyre, Randi F Petersen, Meike Rosenblatt, Annemarie M C van Rossum, Søren A Uldum, Wendy W J Unger, Dominique Ursi, Jonas M Winchell, Cecile Bebear
Detection of Mycoplasma pneumoniae by real-time PCR is not yet standardized across laboratories. We have implemented a standardization protocol to compare the performance of thirteen commercial and in-house approaches. Despite differences on threshold values of samples, all assays were able to detect at least 20M. pneumoniae genomes per reaction.
March 8, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28317104/contact-and-contagion-bighorn-sheep-demographic-states-vary-in-probability-of-transmission-given-contact
#6
Kezia R Manlove, E Frances Cassirer, Raina K Plowright, Paul C Cross, Peter J Hudson
1.Understanding both contact and probability of transmission given contact are key to managing wildlife disease. However, wildlife disease research tends to focus on contact heterogeneity, in part because probability of transmission given contact is notoriously difficult to measure. Here we present a first step toward empirically investigating probability of transmission given contact in free-ranging wildlife. 2.We used measured contact networks to test whether bighorn sheep demographic states vary systematically in infectiousness or susceptibility to Mycoplasma ovipneumoniae, an agent responsible for bighorn sheep pneumonia...
March 20, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28303845/diagnostic-value-of-nasopharyngeal-aspirates-in-children-with-lower-respiratory-tract-infections
#7
Ai-Zhen Lu, Peng Shi, Li-Bo Wang, Li-Ling Qian, Xiao-Bo Zhang
BACKGROUND: The accuracy of nasopharyngeal aspirate (NPA) specimens in detecting lower respiratory pathogens remains controversial. The objective of this study was to evaluate the diagnostic accuracy of aspirates (NPAs) specimen in lower respiratory tract infections (LRTIs) in children. METHODS: The prospective study was designed to collect the data of paired NPAs and bronchoalveolar lavage fluids from children with acute LRTIs from January 2013 to December 2015...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28302886/mycoplasma-bovis-arthritis-and-pneumonia-in-calves
#8
(no author information available yet)
Mycoplasma bovis arthritis and pneumonia in six-month-old calvesSudden deaths in housed suckler cows due to hypomagnesaemiaBovine respiratory syncytial virus infection in two-year-old heifersBovine abortion associated with Parachlamydia speciesFibrinous pericarditis due to Aeromonas hydrophila in weaner pigsThese are among matters discussed in the disease surveillance report for December 2016 from SAC Consulting: Veterinary Services (SAC C VS).
March 18, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28302172/transcriptome-analysis-of-bronchoalveolar-lavage-fluid-from-children-with-severe-mycoplasma-pneumoniae-pneumonia-reveals-novel-gene-expression-and-immunodeficiency
#9
Kuo Wang, Man Gao, Mingyue Yang, Fanzheng Meng, Deli Li, Ruihua Lu, Yan Wang, Huadong Zhuang, Mengyao Li, Genhong Cheng, Xiaosong Wang
BACKGROUND: A growing number of severe Mycoplasma pneumoniae pneumonia (MPP) cases have been reported recently. However, the pathogenesis of severe MPP is not clear. In the current study, transcriptome sequencing was used to identify gene expression and alternative splicing profiles to provide insights into the pathogenesis of severe MPP. METHODS: RNAs of bronchoalveolar lavage fluid (BALF) samples from three severe MPP children and three mild MPP children were analyzed respectively by deep sequencing followed by computational annotation and quantification...
March 16, 2017: Human Genomics
https://www.readbyqxmd.com/read/28288170/therapeutic-efficacy-of-azithromycin-clarithromycin-minocycline-and-tosufloxacin-against-macrolide-resistant-and-macrolide-sensitive-mycoplasma-pneumoniae-pneumonia-in-pediatric-patients
#10
Nobuhisa Ishiguro, Naoko Koseki, Miki Kaiho, Tadashi Ariga, Hideaki Kikuta, Takehiro Togashi, Koji Oba, Keisuke Morita, Naoko Nagano, Masanori Nakanishi, Kazuya Hara, Kyosuke Hazama, Toru Watanabe, Tatsuru Yamanaka, Satoshi Sasaki, Hideto Furuyama, Mutsuo Shibata, Satoru Shida, Akihito Ishizaka, Yuichi Tabata, Hayato Aoyagi, Hiroyuki Naito, Mikio Yoshioka, Atsuko Horino, Tsuyoshi Kenri
OBJECTIVE: To clarify therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia and against macrolide-sensitive Mycoplasma pneumoniae (MSMP) pneumonia in pediatric patients. METHODS: A prospective, multicenter observational study was conducted from July 2013 to August 2015. The therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin were evaluated in 59 patients with pneumonia caused by MRMP and in 50 patients with pneumonia caused by MSMP...
2017: PloS One
https://www.readbyqxmd.com/read/28284605/pro-apoptotic-effect-of-a-mycoplasma-hyopneumoniae-putative-type-i-signal-peptidase-on-pk-15-swine-cells
#11
Jéssica A Paes, Veridiana G Virginio, Martín Cancela, Fernanda M A Leal, Thiago J Borges, Natália Jaeger, Cristina Bonorino, Irene S Schrank, Henrique B Ferreira
Mycoplasma hyopneumoniae is an economically significant swine pathogen that causes porcine enzootic pneumonia (PEP). Important processes for swine infection by M. hyopneumoniae depend on cell surface proteins, many of which are secreted by secretion pathways not completely elucidated so far. A putative type I signal peptidase (SPase I), a possible component of a putative Sec-dependent pathway, was annotated as a product of the sipS gene in the pathogenic M. hyopneumoniae 7448 genome. This M. hyopneumoniae putative SPase I (MhSPase I) displays only 14% and 23% of sequence identity/similarity to Escherichia coli bona fide SPase I, and, in complementation assays performed with a conditional E...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28284602/a-novel-chimeric-protein-composed-of-recombinant-mycoplasma-hyopneumoniae-antigens-as-a-vaccine-candidate-evaluated-in-mice
#12
Natasha Rodrigues de Oliveira, Sérgio Jorge, Charles Klazer Gomes, Caroline Rizzi, Violetta Dias Pacce, Thais Farias Collares, Leonardo Garcia Monte, Odir Antônio Dellagostin
Enzootic Pneumonia (EP) is caused by the Mycoplasma hyopneumoniae pathogenic bacteria, and it represents a significant respiratory disease that is responsible for major economic losses within the pig industry throughout the world. The bacterins that are currently commercially available have been proven to offer only partial protection against M. hyopneumoniae, and the development of more efficient vaccines is required. Several recombinant antigens have been evaluated via different immunization strategies and have been found to be highly immunogenic...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28282391/meteorological-factors-on-the-incidence-of-mp-and-rsv-pneumonia-in-children
#13
Dan-Dan Tian, Rong Jiang, Xue-Jun Chen, Qing Ye
BACKGROUND: Pneumonia is common in children and mostly caused by many pathogens. The aim of this study was to investigate whether the incidence of pediatric mycoplasma pneumoniae (MP) pneumonia and respiratory syncytial virus (RSV) pneumonia was associated with meteorological factors in Hangzhou, China. METHODS: A total of 36500 pneumonia patients were recruited to participate in the study. Nasopharyngeal swabs were collected for the detection of MP and RSV using real-time polymerase chain reaction (RT-PCR) and direct immunofluorescence (DIF) assays, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28272414/defined-chromosome-structure-in-the-genome-reduced-bacterium-mycoplasma-pneumoniae
#14
Marie Trussart, Eva Yus, Sira Martinez, Davide Baù, Yuhei O Tahara, Thomas Pengo, Michael Widjaja, Simon Kretschmer, Jim Swoger, Steven Djordjevic, Lynne Turnbull, Cynthia Whitchurch, Makoto Miyata, Marc A Marti-Renom, Maria Lluch-Senar, Luís Serrano
DNA-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of such bacteria adopt defined three-dimensional structures remains unexplored. Here we combine Hi-C and super-resolution microscopy to determine the structure of the Mycoplasma pneumoniae chromosome at a 10 kb resolution. We find a defined structure, with a global symmetry between two arms that connect opposite poles, one bearing the chromosomal Ori and the other the midpoint...
March 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28264012/comparison-of-culture-and-a-multiplex-probe-pcr-for-identifying-mycoplasma-species-in-bovine-milk-semen-and-swab-samples
#15
Alysia M Parker, John K House, Mark S Hazelton, Katrina L Bosward, Paul A Sheehy
Mycoplasma spp. are a major cause of mastitis, arthritis and pneumonia in cattle, and have been associated with reproductive disorders in cows. While culture is the traditional method of identification the use of PCR has become more common. Several investigators have developed PCR protocols to detect M. bovis in milk, yet few studies have evaluated other sample types or other important Mycoplasma species. Therefore the objective of this study was to develop a multiplex PCR assay to detect M. bovis, M. californicum and M...
2017: PloS One
https://www.readbyqxmd.com/read/28251179/fluorocycline-tp-271-is-potent-against-complicated-community-acquired-bacterial-pneumonia-pathogens
#16
Trudy H Grossman, Corey Fyfe, William O'Brien, Meredith Hackel, Mary Beth Minyard, Ken B Waites, Jacques Dubois, Timothy M Murphy, Andrew M Slee, William J Weiss, Joyce A Sutcliffe
TP-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. TP-271 was active in MIC assays against key community respiratory Gram-positive and Gram-negative pathogens, including Streptococcus pneumoniae (MIC90 = 0.03 µg/ml), methicillin-sensitive Staphylococcus aureus (MSSA; MIC90 = 0.25 µg/ml), methicillin-resistant S. aureus (MRSA; MIC90 = 0.12 µg/ml), Streptococcus pyogenes (MIC90 = 0...
January 2017: MSphere
https://www.readbyqxmd.com/read/28241513/simultaneous-detection-of-nine-key-bacterial-respiratory-pathogens-using-luminex-xtag-%C3%A2-technology
#17
Luxi Jiang, Hongyu Ren, Haijian Zhou, Tian Qin, Yu Chen
Early diagnosis and treatment are crucial to the outcome of lower respiratory tract infections (LRTIs). In this study, we developed an assay combining multiplex PCR and Luminex technology (MPLT) for the detection of nine important respiratory bacterial pathogens, which frequently cause LRTIs. These were Streptococcus pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, Streptococcus pyogenes, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae...
February 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28228838/a-rare-case-of-bilateral-optic-neuritis-and-guillain-barr%C3%A3-syndrome-post-mycoplasma-pneumoniae-infection
#18
Aravindhan Baheerathan, Amy Ross Russell, Fion Bremner, Simon F Farmer
Neurological complications are the most commonly encountered extra-pulmonary manifestation of infection with Mycoplasma pneumoniae (M. pneumoniae). Here the authors report the case of a 39-year-old woman who was admitted with acute-onset bilateral visual loss coinciding with ascending numbness. Clinical examination, neurological imaging, and nerve conduction studies revealed a syndrome of bilateral optic neuritis and Guillain-Barré syndrome (GBS). Serological testing confirmed recent exposure to M. pneumoniae...
February 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28217905/evaluation-of-rv0220-rv2958c-rv2994-and-rv3347c-of-mycobacterium-tuberculosis-for-serodiagnosis-of-tuberculosis
#19
Xiaolong You, Ranhui Li, Kanglin Wan, Liangzhuan Liu, Xiaoping Xie, Lanhua Zhao, Ning Wu, Xiangying Deng, Li Wang, Yanhua Zeng
Tuberculosis (TB), the leading cause of death among infectious diseases worldwide, is caused by Mycobacterium tuberculosis (M. tuberculosis). Early accurate diagnosis means earlier prevention, treatment and control of TB. To confirm efficient diagnostic antigens for M. tuberculosis, the serodiagnosis value of four recombinant proteins including Rv0220, Rv2958c, Rv2994 and Rv3347c was evaluated in this study. The specificities and sensitivities of four recombinant proteins were determined based on enzyme-linked immunosorbent assay (ELISA) by screening sera from smear-positive pulmonary TB patients (n = 92), uninfected individuals (n = 60) and patients with Mycoplasma pneumoniae (n = 32) that potentially cross-react with M...
February 20, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28204467/the-surface-displayed-chaperones-groel-and-dnak-of-mycoplasma-pneumoniae-interact-with-human-plasminogen-and-components-of-the-extracellular-matrix
#20
Lisa Hagemann, Anne Gründel, Enno Jacobs, Roger Dumke
No abstract text is available yet for this article.
February 15, 2017: Pathogens and Disease
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