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https://www.readbyqxmd.com/read/29914546/sex-and-strain-dependent-differences-in-mucosal-immunology-and-microbiota-composition-in-mice
#1
Marlies Elderman, Floor Hugenholtz, Clara Belzer, Mark Boekschoten, Adriaan van Beek, Bart de Haan, Huub Savelkoul, Paul de Vos, Marijke Faas
BACKGROUND: A dysbiosis in the intestinal microbiome plays a role in the pathogenesis of several immunological diseases. These diseases often show a sex bias, suggesting sex differences in immune responses and in the intestinal microbiome. We hypothesized that sex differences in immune responses are associated with sex differences in microbiota composition. METHODS: Fecal microbiota composition (MITchip), mRNA expression in intestinal tissue (microarray), and immune cell populations in mesenteric lymph nodes (MLNs) were studied in male and female mice of two mouse strains (C57B1/6OlaHsd and Balb/cOlaHsd)...
June 18, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29914254/evaluation-of-mesenteric-panniculitis-with-computed-tomography-benign-condition-or-paraneoplastic-syndrome
#2
Ali Küpeli, Ayşegül Cansu, Şükrü Oğuz, Süleyman Bekirçavuşoğlu, Süha Türkmen, Ali Ahmetoğlu, Gürkan Danışan
Background/aim: This study aimed to investigate the prevalence and association of mesenteric panniculitis (MP) with other diseases and the clinicoradiological features of MP, and to examine computed tomography findings to estimate the presence of malignancy in patients with MP. Materials and methods: Between September 2012 and August 2016, we used a keyword search to identify patients diagnosed with MP. Associated diseases and malignancies of patients were recorded. Cut-off values and diagnostic efficiencies of total MP scores and short and long diameters of the greatest lymph nodes were determined...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29913142/plasma-exosomes-regulate-systemic-blood-pressure-in-rats
#3
Kosuke Otani, Mai Yokoya, Tomoko Kodama, Kiko Hori, Kengo Matsumoto, Muneyoshi Okada, Hideyuki Yamawaki
Exosomes, the smallest extracellular vesicle, contain various molecules and mediate cell-cell communication. A number of studies demonstrate exosomes are involved in important physiological and pathological processes. Moreover, microRNA (miRNA) regulating hypertension development through the suppression of certain translation was recently reported. However, roles of exosomes containing various molecules including miRNA on development of essential hypertension have not been examined. We tested the hypothesis that plasma exosomes regulate systemic blood pressure in normotensive and spontaneously hypertensive rats (SHR)...
June 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29912360/expression-levels-of-brown-beige-adipocyte-related-genes-in-fat-depots-of-vitamin-a-restricted-fattening-cattle
#4
Hsuan-Ju Chen, Tsubasa Ihara, Hidetugu Yoshioka, Erina Itoyama, Shoko Kitamura, Hiroshi Nagase, Hiroaki Murakami, Yoichiro Hoshino, Masaru Murakami, Shozo Tomonaga, Tohru Matsui, Masayuki Funaba
Brown/beige adipocytes dissipate energy as heat. We previously showed that brown/beige adipocytes are present in white adipose tissue (WAT) of fattening cattle. The present study examined the effect of vitamin A restriction on mRNA expression of brown/beige adipocyte-related genes. In Japan, fattening cattle are conventionally fed a vitamin A-restricted diet to improve beef marbling. Twelve Japanese Black steers aged 10 months were fed control feed (n=6) or vitamin A-restricted feed (n=6) for 20 months. Subcutaneous WAT (scWAT) and mesenteric WAT (mesWAT) were collected, and mRNA expression levels of molecules related to function of brown/beige adipocytes (Ucp1, Cidea, Dio2, Cox7a and Cox8b) as well as transcriptional regulators related to brown/beige adipogenesis (Zfp516, Nfia, Prdm16, and Pgc-1α) were evaluated...
June 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29911275/inflammation-induced-epithelial-to-mesenchymal-transition-and-gm-csf-treatment-stimulate-mesenteric-mesothelial-cells-to-transdifferentiate-into-macrophages
#5
Sándor Katz, Viktória Zsiros, Nikolett Dóczi, Anna L Kiss
In our previous work, we showed that during inflammation-induced epithelial-to-mesenchymal transition (EMT), mesenteric mesothelial cells express ED1 (pan-macrophage marker), indicating that they are transformed into macrophage-like cells. In this paper, we provide additional evidences about this transition by following the phagocytic activity and the TNFα production of mesenteric mesothelial cells during inflammation. Upon injection of India ink particles or fluorescent-labeled bioparticles (pHrodo) into the peritoneal cavity of rats pretreated with Freund's adjuvant, we found that mesothelial cells efficiently engulfed these particles...
June 18, 2018: Inflammation
https://www.readbyqxmd.com/read/29909663/an-innovative-way-of-managing-coeliac-artery-stenosis-during-pancreaticoduodenectomy
#6
S Balakrishnan, S Kapoor, P Vijayanath, H Singh, A Nandhakumar, K Venkatesulu, V Shanmugam
Coeliac artery stenosis (CAS) is rarely of consequence owing to rich collateral supply from the superior mesenteric artery via the pancreatic head. Pancreaticoduodenectomy (PD) in CAS disrupts these collaterals, and places the liver, stomach and spleen at risk of ischaemia. A 56-year-old man presented with a 3-week history of obstructive jaundice. Computed tomography revealed an operable periampullary tumour with CAS due to compression by the median arcuate ligament with multiple collaterals in the pancreatic head and a prominent gastroduodenal artery (GDA)...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29909661/rectal-varices-due-to-chronic-inferior-mesenteric-vein-thrombosis-caused-by-external-compression-in-a-large-hiatus-hernia-containing-the-pancreas
#7
H A Rudman, M C Stott, M Y Loh, E C Clark
A 79-year-old woman presented with a large fresh rectal bleed. Computed tomography revealed that she had a large type IV hiatus hernia, which contained the stomach and pancreas. Compression of the inferior mesenteric vein and splenic vein had led to thrombosis within these vessels and retrograde flow within the inferior mesenteric vein. This had led to the formation of portosystemic rectal varices. Ectopic varices occasionally form in the rectum, often in the context of liver cirrhosis. At the time of writing, ours is the first reported case of portosystemic rectal varices formulated in response to obstruction of vessels within a hiatus hernia...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29909020/diet-modifies-colonic-microbiota-and-cd4-t-cell-repertoire-to-induce-flares-of-colitis-in-mice-with-myeloid-cell-expression-of-interleukin-23
#8
Lili Chen, Zhengxiang He, Alina Cornelia Iuga, Sebastião N Martins Filho, Jeremiah J Faith, Jose C Clemente, Madhura Deshpande, Anitha Jayaprakash, Jean-Frederic Colombel, Juan J Lafaille, Ravi Sachidanandam, Glaucia C Furtado, Sergio A Lira
BACKGROUND & AIMS: Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis in mice. METHODS: All mice were maintained on lab diet 5053, unless otherwise noted. We generated mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) upon cyclic administration of tamoxifen dissolved in diet 2019...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29907869/bves-is-required-for-maintenance-of-colonic-epithelial-integrity-in-experimental-colitis-by-modifying-intestinal-permeability
#9
Yash A Choksi, Vishruth K Reddy, Kshipra Singh, Caitlyn W Barrett, Sarah P Short, Bobak Parang, Cody E Keating, Joshua J Thompson, Thomas G Verriere, Rachel E Brown, M Blanca Piazuelo, David M Bader, M Kay Washington, Mukul K Mittal, Thomas Brand, Alain P Gobert, Lori A Coburn, Keith T Wilson, Christopher S Williams
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. There have been no in vivo studies investigating the role of BVES in colitis. We hypothesized that BVES is critical for maintaining colonic epithelial integrity. At baseline, Bves -/- mouse colons demonstrate increased crypt height, elevated proliferation, decreased apoptosis, altered intestinal lineage allocation, and dysregulation of tight junctions with functional deficits in permeability and altered intestinal immunity...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29907222/venous-thrombosis-following-pancreaticoduodenectomy-with-venous-resection
#10
Somala Mohammed, Jose E Mendez-Reyes, Amy McElhany, Daniel Gonzales-Luna, George Van Buren, Daniel S Bland, Nicole Villafane-Ferriol, Jeanne A Pierzynski, Charles A West, Eric J Silberfein, William E Fisher
BACKGROUND: Addition of en bloc segmental venous reconstruction (VR) to pancreaticoduodenectomy (PD) for venous involvement of pancreatic tumors increases the complexity of the operation and may increase complications. The long-term mesenteric venous patency rate and oncologic outcome has not been well defined. METHODS: Our prospective database was reviewed to assess 90-day postoperative outcomes for patients who underwent PD or PD + VR (September 2004-June 2016)...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29904248/devascularization-of-the-superior-mesenteric-vein-without-reconstruction-during-surgery-for-retroperitoneal-liposarcoma-a-case-report-and-review-of-literature
#11
Run-Chen Miao, Yong Wan, Xiao-Gang Zhang, Xing Zhang, Yan Deng, Chang Liu
A 61-year-old female patient with chronic hepatitis B virus infection was diagnosed with liposarcoma in a community hospital. Fine needle aspiration biopsy confirmed the diagnosis of well-differentiated liposarcoma. Abdominal computed tomographic angiography (CTA) showed that the mass adhered to and constricted the main trunk and branch of the superior mesenteric vein (SMV), especially the ileocolic vein, and collateral circulation was observed during the vascular reconstruction scan. The abdominal liposarcoma was resected...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29903768/central-administration-of-trv027-improves-baroreflex-sensitivity-and-vascular-reactivity-in-spontaneously-hypertensive-rats
#12
Alynne Carvalho-Galvão, Blessing Ogunlade, Jiaxi Xu, Cristiane R A Silva-Alves, Leônidas G Mendes-Júnior, Drielle D Guimarães, Josiane C Cruz, Thyago M Queiroz, Camille M Balarini, Valdir A Braga, Catalin M Filipeanu, Eric Lazartigues, Maria S França-Silva
TRV027 is a biased agonist for the Angiotensin (Ang)-II type 1 receptor (AT1 R), able to recruit ß-arrestin 2 independently of G-proteins activation. ß-arrestin activation in the central nervous system (CNS) was suggested to oppose the effects of Ang-II. This study evaluates the effect of central infusion of TRV027 on arterial pressure (AP), autonomic function, baroreflex sensitivity and peripheral vascular reactivity. Spontaneously hypertensive (SH) and Wistar Kyoto (WKY) rats were treated with TRV027 for 14 days (20 ng/hour) delivered to the lateral ventricle via osmotic minipumps...
June 14, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29902065/mesenteric-adipose-tissue-contributes-to-intestinal-barrier-integrity-and-protects-against-non-alcoholic-fatty-liver-disease-in-mice
#13
Zhe Wu, Jiang Tan, Yujing Chi, Feng Zhang, Jun Xu, Yang Song, Xu Cong, Na Wu, Yulan Liu
Visceral adipose tissue (VAT) is related to non-alcoholic fatty liver disease (NAFLD). However, the role of mesenteric adipose tissue (MAT), part of the VAT, in NAFLD is unclear. In the present study, we monitored the liver and four depots of the VAT in high fat diet (HFD) feeding mice at multiple time points (4, 8, and 12 weeks). The MAT had become inflamed by the 8th week of HFD feeding, earlier than other depots of VAT. Furthermore, MAT removal after 8 weeks of HFD resulted in more severe steatosis and more foci of inflammation infiltration, as well as higher NAFLD activity scores...
June 14, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29901638/multiple-penetrating-aortic-ulcers-and-rupture-of-superior-mesenteric-artery-branch-presenting-with-symptoms-similar-to-unstable-angina-a-case-report
#14
Suqiao Zhang, Rui Lian, Guoqiang Zhang
RATINALE: Penetrating aortic ulcer (PAU) and rupture of a superior mesenteric artery branch is a rare but potentially life-threatening condition. PATIENT CONCERNS: We describe a case of 73-year-old man was brought to our Emergency Department for intermittent back pain. DIAGNOSES: The final diagnoses are PAU (Stanford B) and rupture of a branch of the superior mesenteric artery. INTERVENTIONS: Two covered stents were placed in the thoracic aorta and the right external iliac artery, and the superior mesenteric artery branch was embolized...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901595/interventional-treatment-of-isolated-dissection-of-the-celiac-artery-a-case-report-and-literature-review
#15
Hai-Tao Wang, Zhi-Hai Yu, Can Tu, Bin Lu
RATIONALE: Isolated dissection of the celiac artery (IDCA) is one of isolated visceral artery dissection, which can occur alone, and can also be complicated with superior mesenteric artery dissection and splenic artery pseudoaneurysm. This disease is very rare in clinic. The exact pathogenesis of IDCA remains unknown. At present, no consensus has yet been reached on the best treatment strategy for this rare disease. In the present study, the clinical data of one IDCA patient diagnosed and treated in our hospital was retrospectively analyzed, and related literatures were reviewed, in order to improve the understanding of the disease...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901457/cystic-intestinal-pneumatosis-of-the-small-gut-etiopathogenesis-and-review-of-literature
#16
Luca Napolitano, Mathew Waku, Gustavo Maggi, Franco Ciarelli
Cystic intestinal pneumatosis (CIP) is the presence of gas bubbles inside the wall of the intestine. In literature it has been reported to be associated with a variety of clinical conditions such as: superior mesenteric ischemia, intestinal perforation, bowel necrosis, infections which can cause mucosal alterations and therefore increasing its permeability, necrotizing enterocolitis in babies, trauma, intestinal obstruction, autoimmune and pulmonary pathologies. Its presence is usually documented by radiological techniques such as abdominal X-ray, CT scan and endoscopy and are usually characterized by the typical pattern of gas bubbles in the wall of the intestine...
March 19, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29900822/is-mesenteric-defect-closure-needed-in-urologic-surgery-using-ileum
#17
Michael A Avallone, Peter N Dietrich, Shanta T Shepherd, Mona Lalehzari, R Corey O'Connor, Michael L Guralnick
INTRODUCTION: Classic surgical teaching advocates for closure of the mesenteric defect (MD) after bowel anastomosis but the necessity is controversial. We sought to evaluate the necessity of MD closure at the time of harvest of ileum for genitourinary reconstructive surgery (GURS) by analyzing the incidence of early and late gastrointestinal adverse events (GIAE) in patients with and without MD closure. MATERIALS AND METHODS: A retrospective review was conducted on patients undergoing urologic reconstruction with ileum to identify incidence of ileus, small bowel obstruction (SBO), gastrointestinal (GI) fistula and stoma complications...
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29900777/clinical-signs-antemortem-diagnostics-and-pathological-findings-associated-with-mycobacterium-avium-subspecies-paratuberculosis-infection-in-mishmi-takin-budorcas-taxicolor-taxicolor
#18
Adam D Naylor, Douglas Richardson, Morag Sellar, Jane Harley, Adrian W Philbey, Simon J Girling
  Mycobacterium avium subspecies paratuberculosis (MAP) is a cause of contagious and typically fatal enteric disease, primarily affecting ruminant and pseudoruminant species. During a MAP outbreak in a captive collection, six of nine adult Mishmi takin ( Budorcas taxicolor taxicolor) showed marked weight loss over 1-3 mo, followed by an acute deterioration. Fecal culture and microscopy failed to identify MAP shedding. Necropsy findings included grossly normal intestines and marked enlargement of mesenteric lymph nodes...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29899562/immunome-differences-between-porcine-ileal-and-jejunal-peyer-s-patches-revealed-by-global-transcriptome-sequencing-of-gut-associated-lymphoid-tissues
#19
T Maroilley, M Berri, G Lemonnier, D Esquerré, C Chevaleyre, S Mélo, F Meurens, J L Coville, J J Leplat, A Rau, B Bed'hom, S Vincent-Naulleau, M J Mercat, Y Billon, P Lepage, C Rogel-Gaillard, J Estellé
The epithelium of the intestinal mucosa and the gut-associated lymphoid tissues (GALT) constitute an essential physical and immunological barrier against pathogens. In order to study the specificities of the GALT transcriptome in pigs, we compared the transcriptome profiles of jejunal and ileal Peyer's patches (PPs), mesenteric lymph nodes (MLNs) and peripheral blood (PB) of four male piglets by RNA-Seq. We identified 1,103 differentially expressed (DE) genes between ileal PPs (IPPs) and jejunal PPs (JPPs), and six times more DE genes between PPs and MLNs...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898964/early-generated-b-1-derived-b-cells-have-the-capacity-to-progress-to-become-mantle-cell-lymphoma-like-neoplasia-in-aged-mice
#20
Kyoko Hayakawa, Anthony M Formica, Yuka Nakao, Daiju Ichikawa, Susan A Shinton, Joni Brill-Dashoff, Mitchell R Smith, Herbert C Morse, Richard R Hardy
In mice, fetal/neonatal B-1 cell development generates murine CD5+ B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a VH 11/D/JH knock-in mouse line (VH 11t) that generates an autoreactive antiphosphatidylcholine BCR. Our study revealed that antiphosphatidylcholine B1a cells develop in liver, mature in spleen, and distribute in intestine/colon, mesenteric lymph node (mLN), and body cavity as the outcome of B-1 cell development before B-2 cell development. Throughout life, self-renewing B-1 B1a cells circulate through intestine, mesenteric vessel, and blood...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
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