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https://www.readbyqxmd.com/read/27908774/increased-incorporation-of-gaseous-co2-into-succinate-by-escherichia-coli-overexpressing-carbonic-anhydrase-and-phosphoenolpyruvate-carboxylase-genes
#1
Soohyun Park, Jae-Ung Lee, Sukhyeong Cho, Hyeonsoo Kim, Han Bin Oh, Seung Pil Pack, Jinwon Lee
Carbon dioxide (CO2) is an abundant and cheap carbon source that is partly responsible for global warming in the atmosphere. The objective of this study was to construct a recombinant E. coli strain that can show enhanced production of succinate derived from CO2. In this study, we confirmed the enhancement of utilization by analyzing succinate containing one carbon-13 ((13)C) derived from (13)CO2. Firstly, the carbonic anhydrase gene (SP(-)HCCA) derived from Hahella chejuensis KCTC 2396 was over-expressed to enhance carbon flux toward bicarbonate ion (HCO3(-)) synthesis in E...
November 28, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27750102/maldi-ms-analysis-and-theoretical-evaluation-of-olanzapine-as-a-uv-laser-desorption-ionization-ldi-matrix
#2
Syed Ghulam Musharraf, Mariam Ameer, Arslan Ali
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) being soft ionization technique, has become a method of choice for high-throughput analysis of proteins and peptides. In this study, we have explored the potential of atypical anti-psychotic drug olanzapine (OLZ) as a matrix for MALDI-MS analysis of peptides aided with the theoretical studies. Seven small peptides were employed as target analytes to check performance of olanzapine and compared with conventional MALDI matrix α-cyano-4-hydroxycinnamic acid (HCCA)...
January 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27608843/dickkopf-1-expression-is-associated-with-tumorigenity-and-lymphatic-metastasis-in-human-hilar-cholangiocarcinoma
#3
Xiang-de Shi, Xian-Huan Yu, Wen-Rui Wu, Xiao-Lin Xu, Jie-Yu Wang, Lei-Bo Xu, Rui Zhang, Chao Liu
Dickkopf-1 (DKK1) is involved in tumorigenesis and the invasion of several tumors. However, its biological function in human hilar cholangiocarcinoma (HCCA) has not yet been documented. This study was designed to investigate the clinical significance and biological function of DKK1 in HCCA. The expression of DKK1 was investigated in thirty-seven human HCCA biopsy samples by immunohistochemistry. To further explore the biological effects of DKK1 in HCCA, transient and stable knockdown of DKK1 in two human HCCA cells (QBC939 and FRH0201) were established using small interfering or short hairpin RNA expression vector...
September 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27452341/mitochondrial-compromise-in-3-year-old-patas-monkeys-exposed-in-utero-to-human-equivalent-antiretroviral-therapies
#4
Yongmin Liu, Eunwoo Shim Park, Alexander T Gibbons, Eric D Shide, Rao L Divi, Ruth A Woodward, Miriam C Poirier
Antiretroviral (ARV) drug therapy, given during pregnancy for prevention of mother-to-child transmission of human immunodeficiency virus 1 (HIV-1), induces fetal mitochondrial dysfunction in some children. However, the persistence/reversibility of that dysfunction is unclear. Here we have followed Erythrocebus patas (patas) monkey offspring for up to 3 years of age (similar in development to a 15-year old human) after exposure of the dams to human-equivalent in utero ARV exposure protocols. Pregnant patas dams (3-5/exposure group) were given ARV drug combinations that included zidovudine (AZT)/lamivudine (3TC)/abacavir (ABC), or AZT/3TC/nevirapine (NVP), for the last 10 weeks (50%) of gestation...
August 2016: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/27373472/-operation-treatment-method-of-bismuth-corlette-%C3%A2-%C3%A2-hilar-cholangiocarcinoma
#5
Z Lu, D D Wang
Hilar cholangiocarcinoma (HCCA) is also known as cancer at the upper part of bile duct, perihilar cholangiocarcinoma or Klatskin tumor, etc.Bismuth-Corlette type Ⅲ hilar cholangiocarcinoma refers to tumor invading right hepatic duct (Ⅲa) or left hepatic duct (Ⅲb). While Bismuth-Corlette type Ⅳ hilar cholangiocarcinoma refers to both left and right intrahepatic bile ducts being invaded. Under the premise of strictly grasping the indications of surgery, if preoperative management is conducted carefully, extended hepatic resection is a safe and feasible surgery to remove Bismuth-Corlette type Ⅲ and type Ⅳ hilar cholangiocarcinoma...
July 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27276221/strict-selection-alone-of-patients-undergoing-liver-transplantation-for-hilar-cholangiocarcinoma-is-associated-with-improved-survival
#6
Hendrik T J Mantel, Andrie C Westerkamp, René Adam, William F Bennet, Daniel Seehofer, Utz Settmacher, Francisco Sánchez-Bueno, Joan Fabregat Prous, Emmanuel Boleslawski, Styrbjörn Friman, Robert J Porte
Liver transplantation for hilar cholangiocarcinoma (hCCA) has regained attention since the Mayo Clinic reported their favorable results with the use of a neo-adjuvant chemoradiation protocol. However, debate remains whether the success of the protocol should be attributed to the neo-adjuvant therapy or to the strict selection criteria that are being applied. The aim of this study was to investigate the value of patient selection alone on the outcome of liver transplantation for hCCA. In this retrospective study, patients that were transplanted for hCCA between1990 and 2010 in Europe were identified using the European Liver Transplant Registry (ELTR)...
2016: PloS One
https://www.readbyqxmd.com/read/27154803/percutaneous-vs-endoscopic-pre-operative-biliary-drainage-in-hilar-cholangiocarcinoma-a-systematic-review-and-meta-analysis
#7
REVIEW
Ahmer Hameed, Tony Pang, Judy Chiou, Henry Pleass, Vincent Lam, Michael Hollands, Emma Johnston, Arthur Richardson, Lawrence Yuen
BACKGROUND: The strategy for preoperative management of biliary obstruction in hilar cholangiocarcinoma (HCCA) patients with regards to drainage by endoscopic (EBD) or percutaneous (PTBD) methods is not clearly defined. The aim of this study was to investigate the utility, complications and therapeutic efficacy of these methods in HCCA patients, with a secondary aim to assess the use of portal vein embolization (PVE) in patients undergoing drainage. METHODS: Studies incorporating HCCA patients undergoing biliary drainage prior to curative resection were included (EMBASE and Medline databases)...
May 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27062713/intraoperative-frozen-section-analysis-of-the-proximal-bile-ducts-in-hilar-cholangiocarcinoma-is-of-limited-value
#8
Hendrik T J Mantel, Andrie C Westerkamp, Egbert Sieders, Paul M J G Peeters, Koert P de Jong, Marieke T Boer, Ruben H de Kleine, Annette S H Gouw, Robert J Porte
Frozen section analysis (FS) during cancer surgery is widely used to assess resection margins. However, in hilar cholangiocarcinoma (HCCA), FS may be less reliable because of the specific growth characteristics of the tumor. The aim of this study was to determine the accuracy and consequences of intraoperative FS of the proximal bile duct margins in HCCA. Between 1990 and 2014, 67 patients underwent combined extrahepatic bile duct resection and partial liver resection for HCCA with the use of FS. Sensitivity and specificity of FS was 68% and 97%, respectively...
July 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27049784/preoperative-cholangitis-and-future-liver-remnant-volume-determine-the-risk-of-liver-failure-in-patients-undergoing-resection-for-hilar-cholangiocarcinoma
#9
Dario Ribero, Giuseppe Zimmitti, Thomas A Aloia, Junichi Shindoh, Fabio Forchino, Marco Amisano, Guillaume Passot, Alessandro Ferrero, Jean-Nicolas Vauthey
BACKGROUND: The highest mortality rates after liver surgery are reported in patients who undergo resection for hilar cholangiocarcinoma (HCCA). In these patients, postoperative death usually follows the development of hepatic insufficiency. We sought to determine the factors associated with postoperative hepatic insufficiency and death due to liver failure in patients undergoing hepatectomy for HCCA. STUDY DESIGN: This study included all consecutive patients who underwent hepatectomy with curative intent for HCCA at 2 centers, from 1996 through 2013...
July 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26972709/characterizing-the-activation-of-the-wnt-signaling-pathway-in-hilar-cholangiocarcinoma-using-a-tissue-microarray-approach
#10
W Chen, J Liang, L Huang, J Cai, Y Lei, J Lai, L Liang, K Zhang
Hilar cholangiocarcinoma (HCCA) is an invasive hepatic malignancy that is difficult to biopsy; therefore, novel markers of HCCA prognosis are needed. Here, the level of canonical Wnt activation in patients with HCCA, intrahepatic cholangiocarcinoma (IHCC), and congenital choledochal cysts (CCC) was compared to understand the role of Wnt signaling in HCCA. Pathology specimens from HCCA (n=129), IHCC (n=31), and CCC (n=45) patients were used to construct tissue microarrays. Wnt2, Wnt3, β-catenin, TCF4, c-Myc, and cyclin D1 were detected by immunohistochemistry...
2016: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/26972523/introduction-of-co3o4-into-activated-honeycomb-like-carbon-for-the-fabrication-of-high-performance-electrode-materials-for-supercapacitors
#11
Myeongjin Kim, Ilgeun Oh, Hyun Ju, Jooheon Kim
In this work, a three-dimensional hierarchical carbon framework/Co3O4 hybrid composite was fabricated. The three-dimensional hierarchical carbon framework was constructed by thermal vapor deposition on the silica nanosphere templates and etching these templates. The resulting carbon framework was activated using phosphoric acid to control its surface area and porosity. The degree of activation of the carbon framework was optimized by measuring the specific capacitance. The carbon framework electrode activated with 3 M phosphoric acid (HCCA(3)) exhibited the highest specific capacitance (134 F g(-1) at 10 mV s(-1))...
April 7, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/26971195/hepatocellular-carcinoma-on-cirrhosis-complicated-with-tumoral-thrombi-extended-to-the-right-atrium-results-in-three-cases-treated-with-major-hepatectomy-and-thrombectomy-under-hypothermic-cardiocirculatory-arrest-and-literature-review
#12
Benedetta Pesi, Francesco Giudici, Luca Moraldi, Gianfranco Montesi, Stefano Romagnoli, Fulvio Pinelli, Pierluigi Stefano, Giacomo Batignani
BACKGROUND: Hepatocellular carcinoma (HCC) with the presence of tumor thrombus in hepatic veins and vena cava, until the atrium (RATT), is correlated with poor prognosis and with risk of tricuspid valve occlusion, congestive heart failure, and pulmonary embolism. METHODS: Three patients with HCC on cirrhotic liver with RATT were studied. Operative technique, pre-operative and post-operative liver function tests, blood loss and transfusions, post-operative morbidity and mortality, and the overall survival and the disease free survival were analyzed...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26864519/polyalanine-a-practical-polypeptide-mass-calibration-standard-for-matrix-assisted-laser-desorption-ionization-mass-spectrometry-and-tandem-mass-spectrometry-in-positive-and-negative-mode
#13
Till Gruendling, Volker Sauerland, César Barahona, Corinna Herz, Ute Nitsch
RATIONALE: Mass calibration in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is currently obtained using mixtures of individual peptides. This procedure has several drawbacks, including laborious preparation, limited shelf life and unequal calibration mass spacing. Polyalanine, a simple to prepare polydisperse molar mass standard, alleviates these problems. METHODS: Polyalanine is prepared by the typical protocols for biological sample analytics...
March 30, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/26831059/dynamic-change-of-total-bilirubin-after-portal-vein-embolization-is-predictive-of-major-complications-and-posthepatectomy-mortality-in-patients-with-hilar-cholangiocarcinoma
#14
Qing Ou Yang, Sheng Zhang, Qing-Bao Cheng, Bin Li, Fei-Ling Feng, Yong Yu, Xiang-Ji Luo, Zhao-Fen Lin, Xiao-Qing Jiang
OBJECTIVES: This study aims to evaluate the role of dynamic change in total bilirubin after portal vein embolization (PVE) in predicting major complications and 30-day mortality in patients with hilar cholangiocarcinoma (HCCA). METHODS: Retrospective analysis of prospectively maintained data of 64 HCCA patients who underwent PVE before hepatectomy in our institution was used. Total bilirubin and other parameters were measured daily in peri-PVE period. The difference between them and the baseline value from days 0-5 to day -1 (∆D1) and days 5-14 to day -1 (∆D2) were calculated...
May 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26829968/changes-in-the-molecular-ion-yield-and-fragmentation-of-peptides-under-various-primary-ions-in-tof-sims-and-matrix-enhanced-tof-sims
#15
Martin Körsgen, Bonnie J Tyler, Andreas Pelster, Dieter Lipinsky, Klaus Dreisewerd, Heinrich F Arlinghaus
Time of flight secondary ion mass spectrometry (ToF-SIMS) is a powerful technique for the nanoanalysis of biological samples, but improvements in sensitivity are needed in order to detect large biomolecules, such as peptides, on the individual cell level at physiological concentrations. Two promising options to improve the sensitivity of SIMS to large peptides are the use of cluster primary ions to increase desorption of intact molecules or the use of matrix-assisted laser desorption/ionization (MALDI) matrices to increase the ionization probability...
June 2016: Biointerphases
https://www.readbyqxmd.com/read/26765439/a-new-surgical-procedure-dumbbell-form-resection-for-selected-hilar-cholangiocarcinomas-with-severe-jaundice-comparison-with-hemihepatectomy
#16
COMPARATIVE STUDY
Shuguang Wang, Feng Tian, Xin Zhao, Dajiang Li, Yu He, Zhihua Li, Jian Chen
The aim of the study is to evaluate the therapeutic effect of a new surgical procedure, dumbbell-form resection (DFR), for hilar cholangiocarcinoma (HCCA) with severe jaundice. In DFR, liver segments I, IVb, and partial V above the right hepatic pedicle are resected.Hemihepatectomy is recognized as the preferred procedure; however, its application is limited in HCCAs with severe jaundice.Thirty-eight HCCA patients with severe jaundice receiving DFR and 70 receiving hemihepatectomy from January 2008 to January 2013 were included...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26663011/combined-vascular-resection-and-analysis-of-prognostic-factors-for-hilar-cholangiocarcinoma
#17
Shu-Tong Wang, Shun-Li Shen, Bao-Gang Peng, Yun-Peng Hua, Bin Chen, Ming Kuang, Shao-Qiang Li, Qiang He, Li-Jian Liang
BACKGROUND: Hilar cholangiocarcinoma (HCCA) is a devastating malignancy arising from the bifurcation of the hepatic duct, whether combined vascular resection benefits HCCA patients is controversial. This study was undertaken to assess the effect of combined vascular resection in HCCA patients and to analyze the prognostic factors. METHODS: Clinical data of 154 HCCA patients who had been treated from January 2005 to December 2012 were retrospectively analyzed. The patients were divided into three groups based on vascular resection: those without vascular resection; those with portal vein resection alone and those with hepatic artery resection...
December 2015: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/26411627/comparative-study-of-different-matrix-solvent-systems-for-the-analysis-of-crude-lyophilized-microalgal-preparations-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#18
COMPARATIVE STUDY
L M Andrade, M A Mendes, P Kowalski, C A O Nascimento
RATIONALE: Due to increases in greenhouse gas emissions, it is necessary to explore renewable sources of energy. Interesting alternatives are biofuels derived from microalgae. One challenge is the development of a detailed microalgae database compiling species identifications and characterizations that would facilitate microalgae selection for biomass production. Mass spectrometric (MS) analysis using a matrix-assisted laser desorption/ionization (MALDI) source is an advanced technique that enables advancement in this biological area...
February 15, 2015: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/26339267/a-complex-multiherbal-regimen-based-on-ayurveda-medicine-for-the-management-of-hepatic-cirrhosis-complicated-by-ascites-nonrandomized-uncontrolled-single-group-open-label-observational-clinical-study
#19
Manish V Patel, Kalapi B Patel, Shivenarain Gupta, Andreas Michalsen, Elmar Stapelfeldt, Christian S Kessler
Hepatic cirrhosis is one of the leading causes of death worldwide, especially if complicated by ascites. This chronic condition can be related to the classical disease entity jalodara in Traditional Indian Medicine (Ayurveda). The present paper aims to evaluate the general potential of Ayurvedic therapy for overall clinical outcomes in hepatic cirrhosis complicated by ascites (HCcA). In form of a nonrandomized, uncontrolled, single group, open-label observational clinical study, 56 patients fulfilling standardized diagnostic criteria for HCcA were observed during their treatment at the P...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26263689/-applicability-of-maldi-mass-spectrometry-for-diagnostics-of-phase-variants-in-bacterial-populations
#20
N A Kryazhevskikh, N G Loiko, E V Demkina, A L Mulyukin, A T Lebedev, A M Gaponov, A V Tutel'yan, Yu A Nikolaeva, G I El'-Registan
Efficiency of MALDI mass spectrometry for differentiation between phenotypic phase variants (in colony morphology and virulence/avirulence) was investigated.for saprotrophic and opportunistically pathogenic bacteria of five genera (Acinetobacter, Arthrobacter, Rhodococcus, Corynebacterium, and Escherichia). Analysis of MALDI spectra (on the SA and HCCA matrices) included: (1) determination of similarity of the protein spectra as a percentage of the common protein peaks to the total amount of proteins, which reflects the phylogenetic relationships of the objects and has been recommended for identification of closely related species; (2) comparison of intensities of the common peaks; and (3) the presence of specific peaks as determinative characteristics of the variants...
May 2015: Mikrobiologiia
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