keyword
https://read.qxmd.com/read/38470915/it-is-theoretically-possible-to-avoid-misfolding-into-non-covalent-lasso-entanglements-using-small-molecule-drugs
#21
JOURNAL ARTICLE
Yang Jiang, Charlotte M Deane, Garrett M Morris, Edward P O'Brien
A novel class of protein misfolding characterized by either the formation of non-native noncovalent lasso entanglements in the misfolded structure or loss of native entanglements has been predicted to exist and found circumstantial support through biochemical assays and limited-proteolysis mass spectrometry data. Here, we examine whether it is possible to design small molecule compounds that can bind to specific folding intermediates and thereby avoid these misfolded states in computer simulations under idealized conditions (perfect drug-binding specificity, zero promiscuity, and a smooth energy landscape)...
March 2024: PLoS Computational Biology
https://read.qxmd.com/read/38470853/programming-heterometallic-4f-4f-helicates-under-thermodynamic-control-the-circle-is-complete
#22
JOURNAL ARTICLE
Charlotte Egger, Laure Guénée, Neel Deorukhkar, Claude Piguet
Three non-symmetrical segmental ligand strands L4 can be wrapped around a linear sequence of one Zn2+ and two trivalent lanthanide cations Ln3+ to give quantitatively directional [ZnLn2 (L4)3 ]8+ triple-stranded helicates in the solid state and in solution. NMR speciations in CD3 CN show negligible decomplexation at a millimolar concentration and the latter helicate can be thus safely considered as a preorganized C 3 -symmetrical HHH -[(L43 Zn)(LnA )(2- n ) (LnB ) n ]8+ platform in which the thermodynamic properties of (i) lanthanide permutation between the central N9 and the terminal N6 O3 binding sites and (ii) exchange processes between homo- and heterolanthanide helicates are easy to access (Ln = La, Eu, Lu)...
March 12, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38470457/inverted-transflection-spectroscopy-of-live-cells-using-metallic-grating-on-elevated-nanopillars
#23
JOURNAL ARTICLE
Aditya Mahalanabish, Steven H Huang, Gennady Shvets
Water absorption of mid-infrared (MIR) radiation severely limits the options for vibrational spectroscopy of the analytes-including live biological cells-that must be probed in aqueous environments. While internal reflection elements, such as attenuated total reflection prisms and metasurfaces, partially overcome this limitation, such devices have their own limitations: ATR prisms are difficult to integrate with multiwell cell culture workflows, while metasurfaces suffer from a limited spectral range and small penetration depth into analytes...
March 12, 2024: ACS Sensors
https://read.qxmd.com/read/38470055/the-recruitment-of-tric-chaperonin-in-rotavirus-viroplasms-correlates-with-virus-replication
#24
JOURNAL ARTICLE
Janine Vetter, Guido Papa, Kurt Tobler, Javier M Rodriguez, Manuel Kley, Michael Myers, Mahesa Wiesendanger, Elisabeth M Schraner, Daniel Luque, Oscar R Burrone, Cornel Fraefel, Catherine Eichwald
UNLABELLED: Rotavirus (RV) replication takes place in the viroplasms, cytosolic inclusions that allow the synthesis of virus genome segments and their encapsidation in the core shell, followed by the addition of the second layer of the virion. The viroplasms are composed of several viral proteins, including NSP5, which serves as the main building block. Microtubules, lipid droplets, and miRNA-7 are among the host components recruited in viroplasms. We investigated the interaction between RV proteins and host components of the viroplasms by performing a pull-down assay of lysates from RV-infected cells expressing NSP5-BiolD2...
March 12, 2024: MBio
https://read.qxmd.com/read/38468182/a-device-related-fistula-between-coronary-artery-and-left-atrial-appendage-following-left-atrial-appendage-closure-case-presentation
#25
Xiaohua Liu, Yizhou Xu
INTRODUCTION: Left atrial appendage (LAA) closure (LAAC) is considered a viable alternative to anticoagulation therapy for stroke prevention in nonvalvular atrial fibrillation, we report a case with a less common shunt resulting from a device-related coronary artery-appendage fistula (CAAF) following LAAC. METHODS AND RESULTS: A 67-year-old male with a history of LAAC was referred to our emergency room with recurrent chest pain and palpitations and was diagnosed with ischemic angina pectoris...
March 11, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38467823/molecular-architecture-and-platelet-activating-properties-of-small-immune-complexes-assembled-on-heparin-and-platelet-factor-4
#26
JOURNAL ARTICLE
Yang Yang, Yi Du, Daniil Ivanov, Chendi Niu, Rumi Clare, James W Smith, Ishac Nazy, Igor A Kaltashov
Heparin-induced thrombocytopenia (HIT) is an adverse reaction to heparin leading to a reduction in circulating platelets with an increased risk of thrombosis. It is precipitated by polymerized immune complexes consisting of pathogenic antibodies that recognize a small chemokine platelet factor 4 (PF4) bound to heparin. Characterization of these immune complexes is extremely challenging due to the enormous structural heterogeneity of such macromolecular assemblies and their constituents. Native mass spectrometry demonstrates that up to three PF4 tetramers can be assembled on a heparin chain, consistent with the molecular modeling studies showing facile polyanion wrapping along the polycationic belt on the PF4 surface...
March 11, 2024: Communications Biology
https://read.qxmd.com/read/38467492/energy-and-speed-landscapes-of-the-membrane-internalization-behavior-of-soft-nanoparticles
#27
JOURNAL ARTICLE
Zhenyu Zhang, Luping Ou, Kai Yang, Bing Yuan
The cellular endocytosis of nanoparticles (NPs) is a fundamental biological process with significant potential in biomedical applications. However, a comprehensive understanding of the mechanistic aspects of endocytosis and the impact of particle properties on this process remains elusive. In this study, we investigated the membrane-wrapping behavior of soft NPs (SNPs) with varying rigidities using theoretical calculations. Our findings reveal that the membrane-wrapping process of SNPs involves a complex energy change including the possible existence of an energy barrier; moreover, it is found that the location and height of this barrier strongly depend on the mechanistic properties of the NPs and membranes...
March 11, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38467165/identification-characterization-and-complete-genome-analysis-of-a-vibrio-anguillarum-isolated-from-sebastes-schlegelii
#28
JOURNAL ARTICLE
Zeyu Li, Yungui Sun, Ruiming Tan, Yingli Gao
Vibrio anguillarum is an important fish pathogen in mariculture, which can infect fish with great economic losses. In this study, a Vibrio anguillarum isolated from Sebastes schlegelii was named VA1 and was identified and characterized from aspects of morphology, physiological and biochemical characteristics, 16SRNA, virulence genes, drug sensitivity, and extracellular enzyme activity. At the same time, The VA1 was investigated at the genomic level. The results showed that a Gram-negative was isolated from the diseased fish...
March 9, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38466848/band-gap-opening-of-metallic-single-walled-carbon-nanotubes-via-noncovalent-symmetry-breaking
#29
JOURNAL ARTICLE
Francesco Mastrocinque, George Bullard, James A Alatis, Joseph A Albro, Animesh Nayak, Nicholas X Williams, Amar Kumbhar, Hope Meikle, Zachary X W Widel, Yusong Bai, Alexis K Harvey, Joanna M Atkin, David H Waldeck, Aaron D Franklin, Michael J Therien
Covalent bonding interactions determine the energy-momentum ( E - k ) dispersion (band structure) of solid-state materials. Here, we show that noncovalent interactions can modulate the E - k dispersion near the Fermi level of a low-dimensional nanoscale conductor. We demonstrate that low energy band gaps may be opened in metallic carbon nanotubes through polymer wrapping of the nanotube surface at fixed helical periodicity. Electronic spectral, chiro-optic, potentiometric, electronic device, and work function data corroborate that the magnitude of band gap opening depends on the nature of the polymer electronic structure...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38464506/a-cadaveric-study-of-the-posterior-band-of-the-inferior-glenohumeral-ligament-of-the-shoulder-and-its-dynamic-behaviour-in-different-arm-positions
#30
JOURNAL ARTICLE
Geoffroy Nourissat, Claire Bastard, Claire Cammas, Vincent Salabi, Anselme Billaud
PURPOSE: The inferior glenohumeral ligament (IGHL) is composed of three parts: the anterior branch or band (AB), the axillary pouch and the posterior band (PB). The latter has rarely been studied. We aim to describe the PB of the IGHL and its dynamic behaviour in different arm positions. METHODS: Twelve fresh cadaveric shoulders were used and the two bands (AB and PB) of the IGHL were dissected and isolated, taking away all muscle, ligaments and capsule. Characteristics of the bands were studied in five positions: maximum external rotation (ER1), abduction (ABD), internal rotation (IR), ABD external rotation (ER2) and anterior elevation-adduction-IR (Hawkins-Kennedy test position)...
January 2024: Journal of Experimental Orthopaedics
https://read.qxmd.com/read/38464265/molecular-density-accelerated-binding-site-maturation-underlies-cenp-t-dependent-kinetochore-assembly
#31
Ekaterina V Tarasovetc, Gunter B Sissoko, Anna S Mukhina, Aleksandr Maiorov, Fazoil I Ataullakhanov, Iain M Cheeseman, Ekaterina L Grishchuk
Formation of macromolecular cellular structures relies on recruitment of multiple proteins, requiring the precisely controlled pairwise binding interactions. At human kinetochores, our recent work found that the high molecular density environment enables strong bonding between the Ndc80 complex and its two binding sites at the CENP-T receptor. However, the mechanistic basis for this unusual density-dependent facilitation remains unknown. Here, using quantitative single-molecule approaches, we reveal two distinct mechanisms that drive preferential recruitment of the Ndc80 complex to higher-order structures of CENP-T, as opposed to CENP-T monomers...
February 26, 2024: bioRxiv
https://read.qxmd.com/read/38461818/do-antibiotic-impregnated-envelopes-prevent-deep-brain-stimulation-implantable-pulse-generator-infections-a-prospective-cohort-study
#32
JOURNAL ARTICLE
Michael Colditz, Tomas Heard, Peter Silburn, Terry Coyne
INTRODUCTION: Infection after deep brain stimulation (DBS) implanted pulse generator (IPG) replacement is uncommon but when it occurs can cause significant clinical morbidity, often resulting in partial or complete DBS system removal. An antibiotic absorbable envelope developed for cardiac implantable electronic devices (IEDs), which releases minocycline and rifampicin for a minimum of 7 days, was shown in the WRAP-IT study to reduce cardiac IED infections for high-risk cardiac patients...
March 8, 2024: Stereotactic and Functional Neurosurgery
https://read.qxmd.com/read/38461077/balanoposthitis-in-children-analysis-of-treatment-diversity-and-development-of-a-treatment-proposal
#33
JOURNAL ARTICLE
Sabine Zundel, Verena Ellerkamp
INTRODUCTION: Balanoposthitis in boys with physiological phimosis is common. Publications on the topic are rare and literature provides no evidence-based guidelines on treatment efficacy. With this study, we aim to analyze treatments currently used, physicians' experience regarding the success and thus derive a treatment proposal. STUDY DESIGN: An online questionnaire was created to evaluate practice patterns and experience. A case scenario, open questions and multiple-choice questions were used to allow multilayered answers...
February 27, 2024: Journal of Pediatric Urology
https://read.qxmd.com/read/38460388/design-of-heterostructured-hydrangea-like-fes-2-mos-2-encapsulated-in-nitrogen-doped-carbon-as-high-performance-anode-for-potassium-ion-capacitors
#34
JOURNAL ARTICLE
Huanyu Liang, Xinyu Wang, Jing Shi, Jingwei Chen, Weiqian Tian, Minghua Huang, Jingyi Wu, Yue Zhu, Huanlei Wang
The means of structural hybridization such as heterojunction construction and carbon-coating engineering for facilitating charge transfer and electron transport are considered viable strategies to address the challenges associated with the low rate capability and poor cycling stability of sulfide-based anodes in potassium-ion batteries (PIBs). Motivated by these concepts, we have successfully prepared a hydrangea-like bimetallic sulfide heterostructure encapsulated in nitrogen-doped carbon (FMS@NC) using a simple solvothermal method, followed by poly-dopamine wrapping and a one-step sulfidation/carbonization process...
March 6, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38458860/accuracy-of-an-artificial-intelligence-based-program-for-locating-the-maxillomandibular-relationship-of-scans-acquired-by-using-intraoral-scanners
#35
JOURNAL ARTICLE
Marta Revilla-León, Miguel Gómez-Polo, Abdul B Barmak, John C Kois, Jorge Alonso Pérez-Barquero
STATEMENT OF PROBLEM: An artificial-intelligence (AI) based program can be used to articulate scans in maximum intercuspal position (MIP) or correct occlusal collisions of articulated scans at MIP; however, the accuracy of the AI program determining the MIP relationship is unknown. PURPOSE: The purpose of the present clinical study was to assess the influence of intraoral scanner (IOS) (TRIOS 5 or i700) and program (IOS or AI-based program) on the accuracy of the MIP relationship...
March 7, 2024: Journal of Prosthetic Dentistry
https://read.qxmd.com/read/38458511/tumor-targeted-delivery-of-copper-manganese-biomineralized-oncolytic-adenovirus-for-colorectal-cancer-immunotherapy
#36
JOURNAL ARTICLE
Yi-Shu Li, Lu-Yi Ye, Yan-Xi Luo, Wen-Jie Zheng, Jing-Xing Si, Xue Yang, You-Ni Zhang, Shi-Bing Wang, Hai Zou, Ke-Tao Jin, Tong Ge, Yu Cai, Xiao-Zhou Mou
Oncolytic viral therapy (OVT) is a novel anti-tumor immunotherapy approach, specifically replicating within tumor cells. Currently, oncolytic viruses are mainly administered by intratumoral injection. However, achieving good results for distant metastatic tumors is challenging. In this study, a multifunctional oncolytic adenovirus, OA@CuMnCs, was developed using bimetallic ions copper and manganese. These metal cations form a biomineralized coating on the virus's surface, reducing immune clearance. It is known that viruses upregulate the expression of PD-L1...
March 6, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38452254/co-assembly-of-amphiphilic-triblock-copolymers-with-nanodrugs-and-drug-release-kinetics-in-solution
#37
JOURNAL ARTICLE
Junwei Zhou, Hao Tang, Rong Wang
Polymeric vesicles present great potential in disease treatment as they can be featured as a structurally stable and easily functionalized drug carrier that can simultaneously encapsulate multiple drugs and release them on-demand. Based on the dissipative particle dynamics (DPD) simulation, the drug-loaded vesicles were designed by the co-assembly process of linear amphiphilic triblock copolymers and hydrophobic nanodrugs in solvents, and most importantly, the drug release behavior of drug-loaded vesicles were intensively investigated...
March 7, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38450799/the-protective-barrier-role-of-satellite-glial-cells-in-sensory-ganglia
#38
JOURNAL ARTICLE
Eman Qarot, Yun Guan, Menachem Hanani
Neurons in sensory ganglia are wrapped completely by satellite glial cells (SGCs). One putative function of SGCs is to regulate the neuronal microenvironment, but this role has received only little attention. In this study we investigated whether the SGC envelope serves a barrier function and how SGCs may control the neuronal microenvironment. We studied this question on short-term (<24 h) cell cultures of dorsal root ganglia and trigeminal ganglia from adult mice, which contain neurons surrounded with SGCs, and neurons that are not...
March 7, 2024: Glia
https://read.qxmd.com/read/38448592/parental-histone-transfer-caught-at-the-replication-fork
#39
JOURNAL ARTICLE
Ningning Li, Yuan Gao, Yujie Zhang, Daqi Yu, Jianwei Lin, Jianxun Feng, Jian Li, Zhichun Xu, Yingyi Zhang, Shangyu Dang, Keda Zhou, Yang Liu, Xiang David Li, Bik Kwoon Tye, Qing Li, Ning Gao, Yuanliang Zhai
In eukaryotes, DNA compacts into chromatin through nucleosomes1,2 . Replication of the eukaryotic genome must be coupled to the transmission of the epigenome encoded in the chromatin3,4 . Here we report cryo-electron microscopy structures of yeast (Saccharomyces cerevisiae) replisomes associated with the FACT (facilitates chromatin transactions) complex (comprising Spt16 and Pob3) and an evicted histone hexamer. In these structures, FACT is positioned at the front end of the replisome by engaging with the parental DNA duplex to capture the histones through the middle domain and the acidic carboxyl-terminal domain of Spt16...
March 6, 2024: Nature
https://read.qxmd.com/read/38448577/thermal-fault-diagnosis-of-complex-electrical-equipment-based-on-infrared-image-recognition
#40
JOURNAL ARTICLE
Zongbu Tang, Xuan Jian
This paper realizes infrared image denoising, recognition, and semantic segmentation for complex electrical equipment and proposes a thermal fault diagnosis method that incorporates temperature differences. We introduce a deformable convolution module into the Denoising Convolutional Neural Network (DeDn-CNN) and propose an image denoising algorithm based on this improved network. By replacing Gaussian wrap-around filtering with anisotropic diffusion filtering, we suggest an image enhancement algorithm that employs Weighted Guided Filtering (WGF) with an enhanced Single-Scale Retinex (Ani-SSR) technique to prevent strong edge halos...
March 6, 2024: Scientific Reports
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