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https://www.readbyqxmd.com/read/29348010/early-outcomes-with-the-evolut-pro-repositionable-self-expanding-transcatheter-aortic-valve-with-pericardial-wrap
#1
John K Forrest, Abeel A Mangi, Jeffrey J Popma, Kamal Khabbaz, Michael J Reardon, Neal S Kleiman, Steven J Yakubov, Daniel Watson, Susheel Kodali, Isaac George, Peter Tadros, George L Zorn, John Brown, Robert Kipperman, Sara Saul, Hongyan Qiao, Jae K Oh, Mathew R Williams
OBJECTIVES: This study sought to evaluate the Medtronic Evolut PRO Transcatheter Aortic Valve System in patients with severe symptomatic aortic stenosis. BACKGROUND: A next-generation self-expanding transcatheter aortic valve was designed with an external pericardial wrap with the intent to reduce paravalvular leak while maintaining the benefits of a low-profile, self-expanding, and repositionable supra-annular valve. METHODS: The Medtronic Evolut PRO Clinical Study included 60 patients undergoing transcatheter aortic valve replacement with the Evolut PRO valve at 8 investigational sites in the United States...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29347752/noise-driven-current-reversal-and-stabilization-in-the-tilted-ratchet-potential-subject-to-tempered-stable-l%C3%A3-vy-noise
#2
Mathew L Zuparic, Alexander C Kalloniatis, Dale O Roberts
We consider motion of a particle in a one-dimensional tilted ratchet potential subject to two-sided tempered stable Lévy noise characterized by strength Ω, fractional index α, skew θ, and tempering λ. We derive analytic solutions to the corresponding Fokker-Planck Lévy equations for the probability density. Due to the periodicity of the potential, we carry out reduction to a compact domain and solve for the analog of steady-state solutions which we represent as wrapped probability density functions. By solving for the expected value of the current associated with the particle motion, we are able to determine thresholds for metastability of the system, namely when the particle stabilizes in a well of the potential and when the particle is in motion, for example as a consequence of the tilt of the potential...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347417/exact-solution-of-the-critical-ising-model-with-special-toroidal-boundary-conditions
#3
Armen Poghosyan, Nickolay Izmailian, Ralph Kenna
The Ising model in two dimensions with special toroidal boundary conditions is analyzed. These boundary conditions, which we call duality-twisted boundary conditions, may be interpreted as inserting a specific defect line ("seam") in the system, along noncontractible circles of the cylinder, before closing it into a torus. We derive exact expressions for the eigenvalues of a transfer matrix for the critical ferromagnetic Ising model on the M×N square lattice wrapped on the torus with a specific defect line...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346303/micro-spherical-sulfur-graphene-oxide-composite-via-spray-drying-for-high-performance-lithium-sulfur-batteries
#4
Yuan Tian, Zhenghao Sun, Yongguang Zhang, Xin Wang, Zhumabay Bakenov, Fuxing Yin
An efficient, industry-accepted spray drying method was used to synthesize micro-spherical sulfur/graphene oxide (S/GO) composites as cathode materials within lithium sulfur batteries. The as-designed wrapping of the sulfur-nanoparticles, with wrinkled GO composites, was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The unique morphological design of this material enabled superior discharge capacity and cycling performance, demonstrating a high initial discharge capacity of 1400 mAh g-1 at 0...
January 18, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29341097/a-postprocedure-wrap-up-tool-for-improving-or-communication-and-performance
#5
Rebecca Norton, Dolores Mordas
In 2015, perioperative nursing staff members at a community hospital designed and implemented a tool to help improve communication and performance. Our postprocedure wrap-up tool and its follow-up process have allowed us to achieve improvements in both efficiency and staff member satisfaction. By implementing a process to document problems as they occur and quickly transmit information to the staff members who are best able to correct these issues, we greatly improved our workflow. Furthermore, by inputting information into spreadsheets using problem codes, thereby replacing anecdotal information with hard data, we targeted areas that needed improvement and used that information for budget planning, training, and allocating resources...
January 2018: AORN Journal
https://www.readbyqxmd.com/read/29340616/pychimera-use-ucsf-chimera-modules-in-any-python-2-7-project
#6
Jaime Rodríguez-Guerra Pedregal, Jean-Didier Maréchal
Motivation: UCSF Chimera (Pettersen et al., 2004) is a powerful visualization tool remarkably present in the computational chemistry and structural biology communities. Built on a C ++ core wrapped under a Python 2.7 environment, one could expect to easily import UCSF Chimera's arsenal of resources in custom scripts or software projects. Nonetheless, this is not readily possible if the script is not executed within UCSF Chimera due to the isolation of the platform. UCSF ChimeraX (Goddard et al...
January 11, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29340554/fundoplication-conversion-in-roux-en-y-gastric-bypass-for-control-of-obesity-and-gastroesophageal-reflux-systematic-review
#7
Antônio Moreira Mendes-Filho, Eduardo Sávio Nascimento Godoy, Helga Cristina Almeida Wahnon Alhinho, Manoel Dos Passos Galvão-Neto, Almino Cardoso Ramos, Álvaro Antônio Bandeira Ferraz, Josemberg Marins Campos
INTRODUCTION: Obesity is related with higher incidence of gastroesophageal reflux disease. Antireflux surgery has inadequate results when associated with obesity, due to migration and/or subsequent disruption of antireflux wrap. Gastric bypass, meanwhile, provides good control of gastroesophageal reflux. OBJECTIVE: To evaluate the technical difficulty in performing gastric bypass in patients previously submitted to antireflux surgery, and its effectiveness in controlling gastroesophageal reflux...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29338185/injectable-and-thermo-sensitive-hydrogel-and-pdlla-electrospun-nanofiber-membrane-composites-for-guided-spinal-fusion
#8
Ying Qu, BeiYu Wang, Bingyang Chu, Chenlu Liu, Xin Rong, Hua Chen, JinRong Peng, Zhiyong Qian
Spinal fusion is the classic treatment to achieve spinal stability for the treatment of the spinal disease. Generally, spinal fusion still has to combine a certain of bone matrix for promoting bone formation to achieve the desired fusion effect based on the surgery, including the traditional bone matrix, such as the autologous bone, allografts and xenografts. Nevertheless, some problems still existed such as the immunogenic problems, the secondary wound, and pathogenic transfer and so on. Here the injectable thermosensitive hydrogel could substitute to avoid the problems as a potential biological scaffold for tissue engineering...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29336149/a-molecular-imprinting-based-hybrid-ratiometric-fluorescence-sensor-for-the-visual-determination-of-bovine-hemoglobin
#9
Xiaoyan Wang, Shuangmei Yu, Wen Liu, Longwen Fu, Yunqing Wang, Jinhua Li, Lingxin Chen
We describe a simple and effective strategy to construct molecular imprinting ratiometric fluorescence sensor (MIR sensor) for the visual detection of bovine hemoglobin (BHb) used as a model protein. The sensor was prepared by simply mixing the solution of green and red CdTe quantum dots (QDs), which were embedded in core-shell structured molecularly imprinted polymers and silica nanoparticles, respectively. The resultant hybrid MIR sensor can selectively bind with BHb and thus quench the fluorescence of the green QDs, while the red QDs wrapped with silica is insensitive to BHb with the fluorescence intensity unchanged...
January 16, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29335429/rfa-guardian-comprehensive-simulation-of-radiofrequency-ablation-treatment-of-liver-tumors
#10
Philip Voglreiter, Panchatcharam Mariappan, Mika Pollari, Ronan Flanagan, Roberto Blanco Sequeiros, Rupert Horst Portugaller, Jurgen Fütterer, Dieter Schmalstieg, Marina Kolesnik, Michael Moche
The RFA Guardian is a comprehensive application for high-performance patient-specific simulation of radiofrequency ablation of liver tumors. We address a wide range of usage scenarios. These include pre-interventional planning, sampling of the parameter space for uncertainty estimation, treatment evaluation and, in the worst case, failure analysis. The RFA Guardian is the first of its kind that exhibits sufficient performance for simulating treatment outcomes during the intervention. We achieve this by combining a large number of high-performance image processing, biomechanical simulation and visualization techniques into a generalized technical workflow...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334016/case-report-to-demonstrate-the-need-for-selection-criteria-for-optimal-adjustable-velcro-wrap-prescription
#11
Suzie Ehmann, Karen Bock
Compression, in the form of either a compression bandage or a compression stocking, has been touted as the gold standard for treatment of swelling and venous leg ulcers (VLUs). Adjustable Velcro wraps have been marketed as compression alternative. Although there is a growing body of evidence to support use of these products, there has not been a critical evaluation of the functionality of the devices to best matching product to patient presentation and ability to use the device effectively. Unlike compression garments, which are classified by compression category (class I/II or flat knit/circular), there is not an algorithm to direct health professionals to best match a specific adjustable Velcro wrap to an individual patient presentation...
January 1, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29332943/bacterial-physiology-it-s-a-wrap-for-burkholderia-flagella
#12
Ursula Hofer
No abstract text is available yet for this article.
January 15, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29332497/dosimetric-analysis-of-microscopic-disease-in-sbrt-for-lung-cancers
#13
Ronghu Mao, Lingling Tian, You Zhang, Lei Ren, Renqi Gao, Fang-Fang Yin, Hong Ge
OBJECTIVE: The objective of this study is to theoretically and experimentally evaluate the dosimetry in the microscopic disease regions surrounding the tumor under stereotactic body radiation therapy of lung cancer. METHODS: For simplicity, the tumor was considered moving along 1 dimension with a periodic function. The probability distribution function of the tumor position was generated according to the motion pattern and was used to estimate the delivered dose in the microscopic disease region...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331810/behavior-of-cylindrospermopsis-raciborskii-during-coagulation-and-sludge-storage-higher-potential-risk-of-toxin-release-than-microcystis-aeruginosa
#14
Hongmin Li, Haiyan Pei, Hangzhou Xu, Yan Jin, Jiongming Sun
Owing to the global warming and its strong adaptability, Cylindrospermopsis raciborskii has spread world-wide. However, as one of toxic cyanobacteria in many drinking water sources, it has not been drawn proper consideration in drinking water treatment plants so far. The investigation aimed at unveiling the fate of C. raciborskii during polyaluminum ferric chloride (PAFC) coagulation and sludge storage, revealing its differences from Microcystis aeruginosa. Results showed that C. raciborskii cells were effectively removed intactly under optimum coagulation conditions, but PAFC at higher dosages (>10 mg/L) triggered additional cylindrospermopsins release...
January 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29330413/nerve-wrap-after-end-to-end-and-tension-free-neurorrhaphy-attenuates-neuropathic-pain-a-prospective-study-based-on-cohorts-of-digit-replantation
#15
Xiaozhong Zhu, Haifeng Wei, Hongyi Zhu
The repair of injured peripheral nerve is still challenging for surgeons. The end-to-end and tension-free neurorrhaphy is the current gold standard for reconstruction after complete nerve transection without significant defect. The main objective of this study neurorrhaphy in digit replantation affects the sensory recovery and neuropathic pain in replanted digit. Total 101 patients who received replantation of single completely amputated digit were included for analysis in this study. In group I (n = 49), the digital nerves were repaired with end-to-end and tension-free neurorrhaphy and then wrapped into a tendon-derived collagen nerve conduit...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330017/a-wrapped-multi-label-classifier-for-the-automatic-diagnosis-and-prognosis-of-alzheimer-s-disease
#16
C Salvatore, I Castiglioni
BACKGROUND: AD is the most frequent neurodegenerative disease, severely impacting our society. Early diagnosis and prognosis are challenging tasks in the management of AD patients. NEW METHOD: We implemented a machine-learning classifier for the automatic early diagnosis and prognosis of AD by means of features extracted, selected and optimized from structural MRI brain images. The classifier was designed to perform multi-label automatic classification into the following four classes: HC, ncMCI, cMCI, and AD...
January 9, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29328703/asymptotic-one-point-functions-in-gauge-string-duality-with-defects
#17
Isak Buhl-Mortensen, Marius de Leeuw, Asger C Ipsen, Charlotte Kristjansen, Matthias Wilhelm
We take the first step in extending the integrability approach to one-point functions in AdS/dCFT to higher loop orders. More precisely, we argue that the formula encoding all tree-level one-point functions of SU(2) operators in the defect version of N=4 supersymmetric Yang-Mills theory, dual to the D5-D3 probe-brane system with flux, has a natural asymptotic generalization to higher loop orders. The asymptotic formula correctly encodes the information about the one-loop correction to the one-point functions of nonprotected operators once dressed by a simple flux-dependent factor, as we demonstrate by an explicit computation involving a novel object denoted as an amputated matrix product state...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29326054/size-based-separation-methods-of-circulating-tumor-cells
#18
Si-Jie Hao, Yuan Wan, Yi-Qiu Xia, Xin Zou, Si-Yang Zheng
Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the peripheral bloodstream. Compared to other "liquid biopsy" portfolios such as exosome, circulating tumor DNA/RNA (ctDNA/RNA), CTCs have incomparable advantages in analyses of transcriptomics, proteomics, and signal colocalization. Hence, CTCs hold the key to understanding the biology of metastasis and play a vital role in cancer diagnosis, treatment monitoring, and prognosis. Size-based enrichment featureS prominently in CTC isolation...
January 8, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29324309/the-promising-future-of-ventricular-restraint-therapy-for-the-management-of-end-stage-heart-failure
#19
REVIEW
Muhammad Naveed, Imran Shair Mohammad, Li Xue, Sara Khan, Wang Gang, Yanfang Cao, Yijie Cheng, Xingxing Cui, Chen DingDing, Yu Feng, Wang Zhijie, Zhou Xiaohui
Complicated pathophysiological syndrome associated with irregular functioning of the heart leading to insufficient blood supply to the organs is linked to congestive heart failure (CHF) which is the leading cause of death in developed countries. Numerous factors can add to heart failure (HF) pathogenesis, including myocardial infarction (MI), genetic factors, coronary artery disease (CAD), ischemia or hypertension. Presently, most of the therapies against CHF cause modest symptom relief but incapable of giving significant recovery for long-term survival outcomes...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29324225/the-marburgvirus-neutralizing-human-monoclonal-antibody-mr191-targets-a-conserved-site-to-block-virus-receptor-binding
#20
Liam B King, Marnie L Fusco, Andrew I Flyak, Philipp A Ilinykh, Kai Huang, Bronwyn Gunn, Robert N Kirchdoerfer, Kathryn M Hastie, Amandeep K Sangha, Jens Meiler, Galit Alter, Alexander Bukreyev, James E Crowe, Erica Ollmann Saphire
Since their first identification 50 years ago, marburgviruses have emerged several times, with 83%-90% lethality in the largest outbreaks. Although no vaccines or therapeutics are available for human use, the human antibody MR191 provides complete protection in non-human primates when delivered several days after inoculation of a lethal marburgvirus dose. The detailed neutralization mechanism of MR191 remains outstanding. Here we present a 3.2 Å crystal structure of MR191 complexed with a trimeric marburgvirus surface glycoprotein (GP)...
January 10, 2018: Cell Host & Microbe
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