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https://www.readbyqxmd.com/read/28453483/remyelination-a-potential-therapeutic-strategy-for-alzheimer-s-disease
#1
Junjun Sun, Hong Zhou, Feng Bai, Zhijun Zhang, Qingguo Ren
Myelin is a lipid-rich multilamellar membrane that wraps around long segments of neuronal axons and it increases the conduction of action potentials, transports the necessary trophic support to the neuronal axons, and reduces the energy consumed by the neuronal axons. Together with axons, myelin is a prerequisite for the higher functions of the central nervous system and complex forms of network integration. Myelin impairments have been suggested to lead to neuronal dysfunction and cognitive decline. Accumulating evidence, including brain imaging and postmortem and genetic association studies, has implicated myelin impairments in Alzheimer's disease (AD)...
April 28, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28447687/can-dual-ligand-targeting-enhance-cellular-uptake-of-nanoparticles
#2
Qiang-Sheng Xia, Hong-Ming Ding, Yu-Qiang Ma
Dual ligand targeting to different types of over-expressed receptors on cell surfaces is a promising strategy in nanomedicine. Here, by using dissipative particle dynamics simulations, the effect of the surface distribution and physicochemical properties of dual ligands on the cellular uptake of nanoparticles is systematically studied. It is found that the spontaneous rearrangement of dual ligands (from random to patterned distribution) on the nanoparticle surface can enhance the cellular uptake of nanoparticles...
April 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28445286/remote-ischemic-preconditioning-improves-the-cognitive-function-of-elderly-patients-following-colon-surgery-a-randomized-clinical-trial
#3
Zhenqiu He, Nan Xu, Sihua Qi
BACKGROUND: Cognitive function impairment is one of the most common complications in elderly patients after surgery, and an ideal nonpharmacological therapy has not yet been identified. Thus, we hypothesized that remote ischemic preconditioning could improve cognitive functions in elderly patients after surgery and investigated the mechanism underlying this effect. METHODS: Ninety patients classified as American Society of Anaesthesiologists (ASA) physical status of 2 or 3 and aged 65 to 75 years who were scheduled for elective colon surgery under general anesthesia were randomly allocated to either a remote ischemic preconditioning group (Group R, n = 45) or a control group (Group C, n = 45)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28442744/biomimetic-antimicrobial-cloak-by-graphene-oxide-agar-hydrogel
#4
Massimiliano Papi, Valentina Palmieri, Francesca Bugli, Marco De Spirito, Maurizio Sanguinetti, Carlotta Ciancico, Maria Chiara Braidotti, Silvia Gentilini, Luca Angelani, Claudio Conti
Antibacterial surfaces have an enormous economic and social impact on the worldwide technological fight against diseases. However, bacteria develop resistance and coatings are often not uniform and not stable in time. The challenge is finding an antibacterial coating that is biocompatible, cost-effective, not toxic, and spreadable over large and irregular surfaces. Here we demonstrate an antibacterial cloak by laser printing of graphene oxide hydrogels mimicking the Cancer Pagurus carapace. We observe up to 90% reduction of bacteria cells...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28438005/comparative-studies-on-the-quality-factors-of-whispering-gallery-modes-and-hybrid-plasmon-photon-modes
#5
Ping Gu, Jiawei Chen, Mingjie Wan, Zhuo Chen, Zhenlin Wang
We theoretically and experimentally investigate the multipolar hybrid plasmon-photon modes supported by a dielectric-metal core-shell resonator consisting of a dielectric core wrapped by a thin silver shell and the whispering-gallery modes in its pure dielectric counterpart (the dielectric sphere with the same size). We theoretically demonstrate that in a certain wavelength range the achievable maximum Q-factors of hybrid modes could be either larger or smaller than that of whispering-gallery modes, depending on the size of the resonator...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28436382/template-free-fabrication-of-graphene-wrapped-mesoporous-znmn2o4-nanorings-as-anode-materials-for-lithium-ion-batteries
#6
Weiwei Zhou, Dong Wang, Limin Zhao, Chunyan Ding, Xingtao Jia, Yu Du, Guangwu Wen, Huatao Wang
We rationally designed a facile two-step approach to synthesize ZnMn2O4@G composite anode material for lithium-ion batteries (LIBs), involving a template-free fabrication of ZnMn2O4 nanorings and subsequent coating of graphene sheets. Notably, it is the first time that ring-like ZnMn2O4 nanostructure is reported. Moreover, our system has been demonstrated to be quite powerful in producing ZnMn2O4 nanorings regardless of the types of Zn and Mn-containging metal salts reactants. The well-known inside-out Ostwald ripening process is tentatively proposed to clarify the formation mechanism of the hollow nanorings...
April 24, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28435946/faraday-discussions-meeting-catalysis-for-fuels
#7
Nico Fischer, Simon A Kondrat, Mzamo Shozi
Welcome to Africa was the motto when after more than 100 years the flag ship conference series of the Royal Society of Chemistry, the Faraday Discussions was hosted for the first time on the African Continent. Under the fitting topic 'Catalysis for Fuels' over 120 delegates followed the invitation by the conference chair Prof. Graham Hutchings FRS (Cardiff Catalysis Institute), his organizing committee and the co-organizing DST-NRF Centre of Excellence in Catalysis c*change (). In the presentations of 21 invited speakers and 59 posters, cutting edge research in the field of catalysis for fuels, designing new catalysts for synthetic fuels, hydrocarbon conversion in the production of synthetic fuels and novel photocatalysis was presented over the two-day meeting...
April 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28434250/rolling-tobacco-in-banana-leaves-newspaper-or-copybook-paper-associated-with-significant-reduction-in-lung-function-in-vanuatu
#8
Charles A Weitz, Kathryn M Olszowy, Kelsey N Dancause, Cheng Sun, Alysa Pomer, Howard Silverman, G Lee, Len Tarivonda, Chim W Chan, Akira Kaneko, J K Lum, Ralph M Garruto
In addition to the widespread availability of packaged cigarettes, the inhabitants of island nations of the Southwest Pacific frequently smoke commercially available loose tobacco using manufactured rolling papers, as well as locally grown tobacco rolled in manufactured rolling paper or wrapped in leaves, copybook paper, and newspaper. In this study, Vanuatu men who smoked local tobacco rolled in leaves, copybook paper, or newspaper showed significantly lower forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC ratios than men who smoked packaged cigarettes, store-bought tobacco rolled in manufactured rolling paper, or who smoked locally grown tobacco rolled in manufactured rolling papers...
April 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28430236/spectral-characterization-and-discrimination-of-synthetic-fibers-with-near-infrared-hyperspectral-imaging-system
#9
Xiaoke Jin, Hafeezullah Memon, Wei Tian, Qinli Yin, Xiaofang Zhan, Chengyan Zhu
Synthetic fibers account for about half of all fiber usage, with applications in every textile field. The phenomenon of fiber composition not matching the label harms consumer interests and impedes market development. Hyperspectral imaging technology as a potential technique can be utilized to discriminate mass synthetic fibers rapidly and nondestructively and achieves the functions that traditional Fourier transform infrared instruments do not have. On the basis of investigating the impact of dope-dyeing and wrapping processes on spectra, the spectral features (from 900 to 2500 nm) of six categories of synthetic fibers were extracted with a hyperspectral imaging system...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28426932/recycling-strategy-for-fabricating-low-cost-and-high-performance-carbon-nanotube-tft-devices
#10
Xiaoqin Yu, Dan Liu, Lixing Kang, Yi Yang, Xiaopin Zhang, Qianjin Lv, Song Qiu, Hehua Jin, Qijun Song, Jin Zhang, Qingwen Li
High-purity semiconducting single-walled carbon nanotubes (s-SWNTs) can be obtained by conjugated polymer wrapping. However, further purification of sorted s-SWNTs and high costs of raw materials are still challenges to practical applications. It is inevitable that a lot of polymers still cover the surface of s-SWNTs after separation, and the cost of the polymer is relatively higher than that of SWNTs. Here, we demonstrated a facile isolated process to improve the quality of s-SWNT solutions and films significantly...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28425698/-dispersion-assembly-approach-to-synthesize-three-dimensional-graphene-polymer-composite-aerogel-as-a-powerful-organic-cathode-for-rechargeable-li-and-na-batteries
#11
Yu Zhang, Yanshan Huang, Guanhui Yang, Fanxing Bu, Ke Li, Imran Shakir, Yuxi Xu
Polymer cathode materials are promising alternatives to inorganic counterparts for both lithium ion batteries (LIBs) and sodium ion batteries (SIBs) due to their high theoretical capacity, adjustable molecular structure and strong adaptability to different counter-ions in batteries, etc. However, they suffer from poor practical capacity and low rate capability because of their intrinsically poor conductivity. Herein, we report the synthesis of self-assembled graphene/poly(anthraquinonyl sufide) (PAQS) composite aerogel (GPA) with efficient integration of three-dimensional (3D) graphene framework with electroactive PAQS particles via a novel dispersion-assembly strategy, which can be used as a free-standing flexible cathode upon mechanical pressing...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28422570/an-induced-adipocyte-sheet-reduces-inflammatory-reactions-during-remodeling-of-xenogeneic-scaffolds-in-vivo
#12
Tong Yi, Qiang Wang, Fan Fan, Gouhui Fan
Surgical therapy of cardiovascular diseases frequently requires replacement of diseased tissues with prosthetic devices or grafts. Calcification is the main reason for the degeneration of implanted grafts. However, some factors reduce stenosis and attenuate calcification of implanted grafts. In this study, we used an autologous induced adipocyte cell-sheet (IACS) as a drug delivery system to determine whether its secretion ability has a beneficial effect on the remodeling process of grafts in a rat subcutaneous model...
April 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28420528/two-dimensional-gas-chromatography-with-electron-capture-detection-for-the-analysis-of-atmospheric-ozone-depleting-halocarbons
#13
Chang-Feng Ou-Yang, Hsi-Che Hua, Yu-Chieh Chou, Ming-Kai Teng, Wen-Tzu Liu, Jia-Lin Wang
This study is to develop a GC×GC method with electron capture detection (ECD) to analyze atmospheric halocarbons in the concentration range of parts per trillion by volume (pptv). To enrich atmospheric halocarbons a home-built thermal desorption (TD) device was coupled to the GC×GC-ECD. The technique of flow modulation was adopted using a Deans switch for GC×GC. Several column combinations of first and second dimensions were tested and the column set of DB-5×TG-1301 was found to show the best orthogonality for halocarbons...
April 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28419245/support-of-the-aortic-wall-a-histological-study-in-sheep-comparing-a-macroporous-mesh-with-low-porosity-vascular-graft-of-the-same-polyethylene-terephthalate-material
#14
Lucas Van Hoof, Peter Verbrugghe, Erik Verbeken, Tom Treasure, Nele Famaey, Bart Meuris, Paul Herijgers, Filip Rega
OBJECTIVES: Wrapping with various materials was an early treatment for aortic aneurysms. Wrapping with low-porosity vascular grafts has been associated with graft migration and vascular erosion. An alternative is to use a macroporous mesh (MPM) made of the same polymer (polyethylene terephalate). We compared the histological outcome 1 year after wrapping sheep aortas with low-porosity grafts versus MPM fabrics. METHODS: The 2 different fabrics were wrapped around the aorta of 3 sheep...
April 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28418104/is-the-nuclear-refractive-index-lower-than-cytoplasm-validation-of-phase-measurements-and-implications-for-light-scattering-technologies
#15
Zachary A Steelman, Will J Eldridge, Jacob B Weintraub, Adam Wax
The refractive index (RI) of biological materials is a fundamental parameter for the optical characterization of living systems. Numerous light scattering technologies are grounded in a quantitative knowledge of the refractive index at cellular and subcellular scales. Recent work in quantitative phase microscopy (QPM) has called into question the widely held assumption that the index of the cell nucleus is greater than that of the cytoplasm, a result which disagrees with much of the current literature. In this work, we critically examine the measurement of the nuclear and whole-cell refractive index using QPM, validating that nuclear refractive index is lower than that of cytoplasm in four diverse cell lines and their corresponding isolated nuclei...
April 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28415912/a-method-for-the-immunohistochemical-identification-and-localization-of-osterix-in-periosteum-wrapped-constructs-for-tissue-engineering-of-bone
#16
Phillip McClellan, Robin Jacquet, Qing Yu, William J Landis
A novel immunohistochemistry (IHC) approach has been developed to label and localize osterix, a bone-specific transcription factor, within formalin-fixed, paraffin-embedded, tissue-engineered constructs uniquely containing synthetic polymers and human periosteal tissue. Generally, such specimens consisting in part of polymeric materials and mineral are particularly difficult for IHC identification of proteins. Samples here were fabricated from human periosteum, electrospun poly-l-lactic acid (PLLA) nanofibers, and polycaprolactone/poly-l-lactic acid (PCL/PLLA, 75/25) scaffolds and harvested following 10 weeks of implantation in athymic mice...
April 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28411819/an-electrochemical-bisphenol-a-sensor-based-on-one-step-electrochemical-reduction-of-cuprous-oxide-wrapped-graphene-oxide-nanoparticles-modified-electrode
#17
Rongguang Shi, Jing Liang, Zongshan Zhao, Aifeng Liu, Yong Tian
Bisphenol A (BPA), as an important industrial material, has been widespread concerned in recent years as its endocrine disrupting effect. This study reported a novel bisphenol A sensor via a facile one step electrochemical reduction of graphene oxide (rGO) and cuprous oxide (Cu2O) nanocomposite modified glassy carbon electrodes. The characterization of the fabricated sensor was performed by scanning electron microscopy and X-ray spectroscopy. The prepared Cu2O-rGO electrode presented fast response, high sensitivity and low background current...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411646/nano-armoring-of-enzymes-rational-design-of-polymer-wrapped-enzymes
#18
Kishore Raghupathi, Sankaran Thayumanavan
The formulation in which therapeutic proteins are administered plays a key role in retaining their biological activity. Enzyme wrapping, using synthetic polymers, is a strategy employed to provide enzymes with lower immunogenicity, longer circulation times, and better targeting capabilities. Protein-polymer complexation methods, involving covalent, noncovalent, and electrostatic interactions, that can provide means to develop formulations for retaining enzyme stability are discussed in this chapter. Amphiphilic self-cross-linkable polymer was used to encapsulate capsase-3 enzyme in the nanogel, while inverse emulsion polymerization method was used to entrap α-glucosidase enzyme in the nanogel...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28409108/hamstring-graft-biological-preparation-for-anterior-cruciate-ligament-reconstruction
#19
Nuno Camelo Barbosa, Francisco Guerra-Pinto, Claudia Cabeleira, Pedro Beja da Costa
The all-inside anterior cruciate ligament reconstruction (ACLR) success depends on biologic integration of the graft in the bone tunnel. Sutures wrapping the tendon in the bone tunnel may affect tendon-bone healing in shorter bone tunnels. To achieve better graft integration, we propose a variation of the graft link suture technique wherein the graft is linked chain-like to the femoral and tibial TightRope (Arthrex), which increases the tendon-bone contact area by eliminating sutures from the noose of the graft and thus may allow better graft integration...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28408607/crystal-structure-of-the-overlapping-dinucleosome-composed-of-hexasome-and-octasome
#20
Daiki Kato, Akihisa Osakabe, Yasuhiro Arimura, Yuka Mizukami, Naoki Horikoshi, Kazumi Saikusa, Satoko Akashi, Yoshifumi Nishimura, Sam-Yong Park, Jumpei Nogami, Kazumitsu Maehara, Yasuyuki Ohkawa, Atsushi Matsumoto, Hidetoshi Kono, Rintaro Inoue, Masaaki Sugiyama, Hitoshi Kurumizaka
Nucleosomes are dynamic entities that are repositioned along DNA by chromatin remodeling processes. A nucleosome repositioned by the switch-sucrose nonfermentable (SWI/SNF) remodeler collides with a neighbor and forms the intermediate "overlapping dinucleosome." Here, we report the crystal structure of the overlapping dinucleosome, in which two nucleosomes are associated, at 3.14-angstrom resolution. In the overlapping dinucleosome structure, the unusual "hexasome" nucleosome, composed of the histone hexamer lacking one H2A-H2B dimer from the conventional histone octamer, contacts the canonical "octasome" nucleosome, and they intimately associate...
April 14, 2017: Science
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