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https://www.readbyqxmd.com/read/28092098/evaluation-the-ethnopharmacological-studies-in-iran-during-2004-2016-a-systematic-review
#1
REVIEW
Zahra Sadeghi, Maryam Akaberi, Seyed Ahmad Emami, Alireza Sobhkhizi, Amirhossein Sahebkar
Although Iran has a deep history in herbal medicine and great heritage of ancient medical scholars, few efforts have been made to evaluate ethnopharmacological aspects of medicinal plants in this country. In the present study, the authors have reviewed all important literature about the ethnopharmacological investigations on medicinal plants used in the last decade in Iran. All provinces of Iran were categorized according to a phytogeographical division. Information was collected through bibliographic investigations from scientific journals and books...
January 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28091732/thieme-atlas-of-anatomy-internal-organs-2nd-edition-michael-schuenke-erik-schulte-udo-schumacher-editors-wayne-a-cass-consulting-editor-markus-voll-karl-wesker-illustrations-thieme-medical-publishers-inc-2016-isbn-978-1-62623-166-5
#2
https://www.readbyqxmd.com/read/28090681/excess-of-exercise-increases-the-risk-of-atrial-fibrillation
#3
REVIEW
A Müssigbrodt, A Weber, J Mandrola, Y van Belle, S Richter, M Döring, A Arya, P Sommer, A Bollmann, G Hindricks
An interesting and still not well-understood example for old medical wisdom "Sola dosis facit venenum" is the increased prevalence of atrial fibrillation (AF) in athletes. Numerous studies have shown a fourfold to eightfold increased risk of AF in athletes compared to the normal population. Analysis of the existing data suggests a dose-dependent effect of exercise. Moderate exercise seems to have a protective effect and decreases the risk of AF, whereas excessive exercise seems to increase the risk of AF. The described cases illustrate clinical manifestations within the spectrum of AF in elderly athletes, that is, exercise-induced AF, vagal AF, chronic AF, and atrial flutter...
January 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28087720/a-liminal-stage-after-predictive-testing-for-huntington-disease
#4
Marcela Gargiulo, Sophie Tezenas du Montcel, Marie France Jutras, Ariane Herson, Cecile Cazeneuve, Alexandra Durr
BACKGROUND: Following predictive testing for Huntington disease (HD), knowledge of one's carrier status may have consequences on disease onset. Our study aimed to address two questions. First, does knowledge of being a carrier of the pathological HD mutation trigger onset of the disease? Second, does this knowledge influence self-awareness and allow carriers to identify signs and symptoms of disease onset? METHODS: Between 2012 and 2015, 75 HD mutation carriers were examined using the Unified Huntington's Disease Rating Scale (UHDRS) motor score...
January 13, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28074748/possible-parkinson-s-disease-induced-by-chronic-manganese-supplement-ingestion
#5
Michael J Schuh
OBJECTIVE: The objective is to report a case of possible neurotoxicity resulting from an incorrect dietary supplement for osteoporosis taken at a toxic dose. SUMMARY: The case study examined here is a 37-year-old African-American female who consumed excessive manganese over a period of years, resulting in Parkinson's disease (PD). This patient was referred to the pharmacist pharmacotherapy service by a neurology physician. PD has been shown in the medical literature to be caused by chronic exposure to high levels of manganese...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28074570/development-of-the-sbirt-checklist-for-observation-in-real-time-score
#6
Janice A Vendetti, Bonnie G McRee, Frances K Del Boca
BACKGROUND AND AIMS: Screening, Brief Intervention and Referral to Treatment (SBIRT) programs have been implemented widely in medical settings, with little attention focused on how well providers adhere to evidence-based service delivery in everyday practice. The purposes of this paper were to: (1) introduce a flexible, relatively simple methodology, the SBIRT Checklist for Observation in Real-time (SCORe), to assess adherence to evidence-based practice and provide preliminary evidence supporting its criterion validity; and (2) illustrate the feasibility and potential utility of the SCORe by analyzing observations of providers within four large-scale SBIRT programs in the United States...
February 2017: Addiction
https://www.readbyqxmd.com/read/28073867/the-maimed-martian-credible-intervals-and-bias-against-benefit
#7
David Kault
A sad little story about a maimed Martian astronaut is used to illustrate a method of improving confidence interval (CI) calculations. CIs in medical statistics are currently calculated from the data available in a clinical trial or meta-analysis considered in isolation from all other information available on earth. Likewise, the Martian in the story uses only information available to it, in isolation from further information from earth. However, there is further objective knowledge available to people on earth to improve the Martian's estimate...
January 10, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28069002/unpacking-early-infant-male-circumcision-decision-making-using-qualitative-findings-from-zimbabwe
#8
Webster Mavhu, Karin Hatzold, Getrude Ncube, Shamiso Fernando, Collin Mangenah, Kumbirai Chatora, Roy Dhlamini, Owen Mugurungi, Ismail Ticklay, Frances M Cowan
BACKGROUND: Early infant male circumcision (EIMC) has been identified as a key HIV prevention intervention. Exploring the decision-making process for adoption of EIMC for HIV prevention among parents and other key stakeholders is critical for designing effective demand creation interventions to maximize uptake, roll out and impact in preventing HIV. This paper describes key players, decisions and actions involved in the EIMC decision-making process. METHODS: Two complementary qualitative studies explored hypothetical and actual acceptability of EIMC in Zimbabwe...
January 9, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28064514/statistics-myth-busters
#9
Simon W Lam, Seth R Bauer, Wei Yang, Todd A Miano
Proficiency in research design and statistical analysis is crucial to the success of a clinical pharmacist. However, new pharmacy graduates and residents may not have received adequate training and education in these areas. During the authors' tenure as clinical pharmacists, several statistical "myths" were consistently maintained by residents and new clinical practitioners. The purpose of this narrative review is to discuss and dispel several of these statistical fallacies. The myths discussed involve 3 common areas of consideration when evaluating any clinical study: assessing the risk of bias from confounding (propensity score analysis and multivariable modeling), interpretation of the main study findings ( P values and hypothesis testing), and secondary evaluations (subgroup analyses)...
January 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28063739/development-of-left-atrial-thrombus-after-coadministration-of-dabigatran-etexilate-and-phenytoin
#10
Nicole Hager, Jennifer Bolt, Lori Albers, Wladyslaw Wojcik, Patrick Duffy, William Semchuk
Dabigatran etexilate is a substrate of the P-glycoprotein (adenosine triphosphate-binding cassette subfamily B member 1) transport system and is subject to interactions with medications that induce or inhibit this system. The clinical relevance of the interaction between dabigatran and phenytoin has not been well described. We report a case of left atrial thrombus in a patient receiving concomitant dabigatran etexilate and phenytoin, which is a P-glycoprotein inducer. This case illustrates the potential clinical significance of the interactions of medications that affect P-glycoprotein and dabigatran...
October 28, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28061790/closing-the-gender-leadership-gap-a-multi-centre-cross-country-comparison-of-women-in-management-and-leadership-in-academic-health-centres-in-the-european-union
#11
Ellen Kuhlmann, Pavel V Ovseiko, Christine Kurmeyer, Karin Gutiérrez-Lobos, Sandra Steinböck, Mia von Knorring, Alastair M Buchan, Mats Brommels
BACKGROUND: Women's participation in medicine and the need for gender equality in healthcare are increasingly recognised, yet little attention is paid to leadership and management positions in large publicly funded academic health centres. This study illustrates such a need, taking the case of four large European centres: Charité - Universitätsmedizin Berlin (Germany), Karolinska Institutet (Sweden), Medizinische Universität Wien (Austria), and Oxford Academic Health Science Centre (United Kingdom)...
January 6, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28061777/whatsapp-messenger-as-a-tool-to-supplement-medical-education-for-medical-students-on-clinical-attachment
#12
Lewis Raiman, Richard Antbring, Asad Mahmood
BACKGROUND: Instant messaging applications have the potential to improve and facilitate communication between hospital doctors and students, hence generating and improving learning opportunities. This study aims to demonstrate the feasibility and acceptability of instant messaging communication to supplement medical education for medical students whilst on clinical attachment. METHODS: A total of 6 WhatsApp Messenger (WhatsApp Inc.) groups were created for medical students on clinical attachment...
January 6, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28059930/acr-appropriateness-criteria-locally-advanced-high-risk-prostate-cancer
#13
Patrick W McLaughlin, Adam L Liss, Paul L Nguyen, Dean G Assimos, Anthony V D'Amico, Alexander R Gottschalk, Gary S Gustafson, Sameer R Keole, Stanley L Liauw, Shane Lloyd, Benjamin Movsas, Bradley R Prestidge, Timothy N Showalter, Al V Taira, Neha Vapiwala, Brian J Davis
PURPOSE: To present the most updated American College of Radiology consensus guidelines formed from an expert panel on treatment of locally advanced, high-risk prostate cancer METHODS:: The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios...
January 4, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28059689/an-integrated-health-neighbourhood-framework-to-optimise-the-use-of-ehr-data
#14
Siaw-Teng Liaw, Simon De Lusignan
 General practice should become the hub of integrated health neighbourhoods (IHNs), which involves sharing of information to ensure that medical homes are also part of learning organisations that use electronic health record (EHR) data for care, decision making, teaching and learning, quality improvement and research. The IHN is defined as the primary and ambulatory care services in a locality that relates largely to a single hospital-based secondary care service provider and is the logical denominator and unit of comparison for the optimal use of EHR data and health information exchange (HIE) to facilitate integration and coordination of care...
October 4, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28057709/when-parents-choose-gender-intersex-children-and-the-law
#15
Melanie Newbould
In England and Wales, it is usually lawful for those with parental responsibility to consent to treatment on children who have not acquired legal capacity, providing that they are acting in the child's best interests. Whilst in most instances this process is unproblematic and the decisions made are non-controversial, there are troubling examples where this is more problematic. The difficulties for a family with a child who has an intersex condition will be considered to illustrate that there may be cases of medical and surgical treatment where even though both parents and doctors agree on a course of action in good faith, the treatment administered may not necessarily be in the best interests of the child...
January 5, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28056008/traumatic-brain-and-spinal-cord-fatalities-among-high-school-and-college-football-players-united-states-2005-2014
#16
Kristen L Kucera, Rebecca K Yau, Johna Register-Mihalik, Stephen W Marshall, Leah C Thomas, Susanne Wolf, Robert C Cantu, Frederick O Mueller, Kevin M Guskiewicz
An estimated 1.1 million high school and 75,000 college athletes participate in tackle football annually in the United States. Football is a collision sport; traumatic injuries are frequent (1,2), and can be fatal (3). This report updates the incidence and characteristics of deaths caused by traumatic brain injury and spinal cord injury (4) in high school and college football and presents illustrative case descriptions. Information was analyzed from the National Center for Catastrophic Sport Injury Research (NCCSIR)...
January 6, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28054373/birnbaum-saunders-frailty-regression-models-diagnostics-and-application-to-medical-data
#17
Jeremias Leão, Víctor Leiva, Helton Saulo, Vera Tomazella
In survival models, some covariates affecting the lifetime could not be observed or measured. These covariates may correspond to environmental or genetic factors and be considered as a random effect related to a frailty of the individuals explaining their survival times. We propose a methodology based on a Birnbaum-Saunders frailty regression model, which can be applied to censored or uncensored data. Maximum-likelihood methods are used to estimate the model parameters and to derive local influence techniques...
January 5, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28052822/applying-a-conceptual-framework-to-maximize-the-participation-of-diverse-populations-in-cancer-clinical-trials
#18
A Napoles, E Cook, T Ginossar, K D Knight, M E Ford
The underrepresentation of ethnically diverse populations in cancer clinical trials results in the inequitable distribution of the risks and benefits of this research. Using a case study approach, we apply a conceptual framework of factors associated with the participation of diverse population groups in cancer clinical trials developed by Dr. Jean Ford and colleagues to increase understanding of the specific strategies, and barriers and promoters addressed by these strategies, that resulted in marked success in accrual of racially and ethnically diverse populations in cancer clinical research...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28050803/access-to-controlled-medicines-for-anesthesia-and-surgical-care-in-low-income-countries-a-narrative-review-of-international-drug-control-systems-and-policies
#19
Jason W Nickerson, Katherine Pettus, Kathleen E Wheeler, Christopher Hallam, David R Bewley-Taylor, Amir Attaran, Adrian W Gelb
PURPOSE: This article describes the functioning of the international drug control system, its integration into national legislation and policy, and the collective impact on access to medicines. SOURCE: We conducted a review of the three international drug control conventions, peer-reviewed articles, and grey literature known to the authors that describes national and international drug control systems and their impact on access to controlled medicines. This review was supplemented with literature derived from a structured search of MEDLINE(®) for articles relating to medical uses of ketamine in low- and middle-income countries conducted to strengthen an advocacy campaign...
January 3, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28050623/clinical-relevance-of-the-stopp-start-criteria-in-hip-fracture-patients
#20
Johan Lönnbro, Susanna M Wallerstedt
PURPOSE: The aim of this study was to investigate the clinical relevance of potentially inappropriate medications (PIMs), identified by the STOPP criteria, and potential prescribing omissions (PPOs), identified by the START criteria, and to identify predictors for clinically relevant PIMs and PPOs. METHODS: The STOPP and START criteria were applied on the medication lists of 200 older hip fracture patients, consecutively recruited to a randomized controlled study in 2009...
January 3, 2017: European Journal of Clinical Pharmacology
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