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https://www.readbyqxmd.com/read/29917290/hypoxic-pulmonary-vasoconstriction-in-isolated-mouse-pulmonary-arterial-vessels
#1
Ievgen Strielkov, Nicole Catherine Krause, Natasha Sommer, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Thomas Gudermann, Alexander Dietrich, Norbert Weissmann
NEW FINDINGS: What is the central question of this study? Hypoxic pulmonary vasoconstriction has never been characterized in isolated mouse pulmonary arteries of different generations in detail. What is the main finding and its importance? We found that only small intrapulmonary arteries (80 - 200 μm in diameter) exhibit hypoxic pulmonary vasoconstriction. The observed response was sustained, significantly potentiated by depolarization-induced preconstriction, and not dependent on endothelium and TRPC6 channels...
June 19, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29917280/protective-effects-of-cinnamon-bark-extract-against-ischemia-reperfusion-injury-and-arrhythmias-in-rat
#2
Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion...
June 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29917272/enhancing-the-effects-of-exfoliated-carbon-nanofibers-using-bone-morphogenetic-protein-in-a-rat-spinal-fusion-model
#3
Naoki Notani, Masashi Miyazaki, Masahiro Toyoda, Shozo Kanezaki, Toshinobu Ishihara, Hiroshi Tsumura
Exfoliated carbon nanofibers (ExCNFs) are expected to serve as excellent scaffolds for promoting and guiding bone-tissue regeneration. We aimed to enhance the effects of ExCNFs using bone morphogenetic proteins (BMPs) and examined their feasibility and safety in clinical applications using a rat spinal fusion model. Group I (n = 15) animals were implanted with the control carrier; Group II (n = 16) animals were implanted with carrier containing 1 μg ExCNFs; Group III (n = 16) animals were implanted with carrier containing 1 μg recombinant human (rh) BMP-2; and Group IV (n = 17) animals were implanted with carrier containing 1 μg rhBMP-2 and 1 μg ExCNFs...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29917248/population-variability-in-animal-health-influence-on-dose-exposure-response-relationships-part-i-drug-metabolism-and-transporter-systems
#4
Marilyn N Martinez, Michael H Court, Johanna Fink-Gremmels, Katrina L Mealey
There is an increasing effort to understand the many sources of population variability that can influence drug absorption, metabolism, disposition, and clearance in veterinary species. This growing interest reflects the recognition that this diversity can influence dose-exposure-response relationships and can affect the drug residues present in the edible tissues of food-producing animals. To appreciate the pharmacokinetic diversity that may exist across a population of potential drug product recipients, both endogenous and exogenous variables need to be considered...
June 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29917246/protective-effect-of-tadalafil-and-verapamil-on-testicular-function-and-oxidative-stress-after-torsion-detorsion-in-adult-male-rat
#5
Mojtaba Ameli, Mohaddeseh Sadat Hashemi, Maryam Moghimian, Majid Shokoohi
OBJECTIVE: This study used a rat model to investigate the protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion. METHODS AND MATERIALS: Animals were randomly divided into five groups: G1, Sham group; G2, testicular torsion followed by detorsion (TD); G3, testicular torsion/detorsion received 0/4 mg/kg of tadalafil (TDT); G4, testicular torsion/detorsion received 0/1 mg/kg of verapamil (TDV); and G5, testicular torsion/detorsion received 0/1 mg/kg of verapamil and 0/4 mg/kg of tadalafil (TDTV)...
June 19, 2018: Andrologia
https://www.readbyqxmd.com/read/29917216/expression-level-of-proteoglycan-collagen-and-type-ii-collagen-in-osteoarthritis-rat-model-is-promoted-and-degradation-of-cartilage-is-prevented-by-glucosamine-methyl-ester
#6
X-X Wang, L Cai
OBJECTIVE: In the current study, the effect of glucosamine methyl ester on cartilage degeneration in osteoarthritis rat model was investigated. MATERIALS AND METHODS: Forty Sprague-Dawley rats were assigned into 5 groups of 8 animals each. Osteoarthritis was induced in 4 groups using medial parapatellar incision followed by anterior cruciate ligament transection and meniscectomy. Normal and model osteoarthritis groups were given normal saline. The three treatment groups received 2, 5 and 10 mg/kg doses of glucosamine methyl ester daily for one month...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917204/sestrin2-aggravates-oxidative-stress-of-neurons-by-decreasing-the-expression-of-nrf2
#7
L-L Zhang, Z-J Zhang
OBJECTIVE: Oxidative injury is an essential part of the pathological changes of cerebral ischemia-reperfusion. Sestrin2 (Sesn2), a conserved antioxidant protein, is activated under stress to protect cells against oxidative stress. This study mainly explored the function and mechanism of Sesn2 during cerebral ischemia-reperfusion injury in rats. MATERIALS AND METHODS: Oxygen-glucose deprivation/reoxygenation (OGD/R) model of primary neurons was established. MTS and LDH (lactate dehydrogenase) kit were used to detect cell viability and cell damage by colorimetric method...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917121/new-insights-into-spinal-cord-ischaemia-after-thoracic-aortic-procedures-the-importance-of-the-number-of-anterior-radiculomedullary-arteries-for-surgical-outcome
#8
Fabian A Kari, Babak Saravi, Sonja Krause, Luisa Puttfarcken, Johannes Scheumann, Katharina Förster, Bartosz Rylski, Sven Maier, Ulrich Göbel, Matthias Siepe, Martin Czerny, Friedhelm Beyersdorf
OBJECTIVES: Anterior radiculomedullary arteries (ARMAs) link dorsal segmental arteries and the intraspinal compartment of the spinal collateral network. The number of thoracic ARMA is highly variable from one person to another. The impact of the number of ARMAs on spinal cord perfusion during thoracic aortic procedures is unknown. We investigated the influence of the number of thoracic ARMAs on spinal cord perfusion in an aortic surgical large animal model. METHODS: Twenty-six pigs were included (20 treatment animals, 6 sham animals, weight 34 ± 3 kg)...
July 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29917103/animal-production-and-soil-characteristics-from-integrated-crop-livestock-systems-toward-sustainable-intensification
#9
Paulo César de Faccio Carvalho, Caitlin Adair Peterson, Pedro Arthur de Albuquerque Nunes, Amanda Posselt Martins, William de Souzsa Filho, Vanessa Thoma Bertolazi, Taíse Robinson Kunrath, Aníbal de Moraes, Ibanor Anghinoni
Sustainable intensification of land-use practices has never been more important to ensure food security for a growing world population. When combined under thoughtful management, cover cropping and crop-livestock integration under no-till systems can benefit from unexpected synergies due to their unique features of plant-animal diversification and complex agroecosystem functions. Mimicking the nutrient coupling/decoupling processes of natural ecosystems by diversifying plant and animal components of no-till integrated crop-livestock operations is an essential feature of the design of agroecological systems that support self-regulating feedbacks and lend resilience while increasing productivity and ecosystem service provision...
June 16, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29917102/performance-enhancing-technologies-for-steers-grazing-tall-fescue-pastures-with-varying-levels-of-toxicity
#10
Jose M Diaz, M Shane Gadberry, Paul A Beck, John T Richeson, G Douglas Hufstedler, Don S Hubbell, John D Tucker, Tom Hess, Ky G Pohler
The objective of this study was to evaluate a combination of best management practices strategy for steer calves grazing tall fescue pastures with a range of toxicity. The experiment was conducted over two grazing seasons (fall 2015 for 91 days and spring 2016 for 84 days). Steers (n = 80 within season, BW = 197.0 ± 15.43 kg [fall] and 116.9 ± 4.88 [spring]) were stocked at 2.45 and 4.1 calves/hectare in fall and spring, respectively, to 16 pastures with varying levels of toxicity based on interim ergovaline (EV) concentration within season...
June 16, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29917101/fgf-signaling-deregulation-is-associated-with-early-developmental-skeletal-defects-in-animal-models-for-mucopolysaccharidosis-type-ii-mpsii
#11
Stefania Bellesso, Marika Salvalaio, Susanna Lualdi, Elisa Tognon, Roberto Costa, Paola Braghetta, Chiara Giraudo, Roberto Stramare, Laura Rigon, Mirella Filocamo, Rosella Tomanin, Enrico Moro
No abstract text is available yet for this article.
July 1, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29917089/inference-of-developmental-gene-regulatory-networks-beyond-classical-model-systems-new-approaches-in-the-post-genomic-era
#12
Selene L Fernandez-Valverde, Felipe Aguilera, René Alexander Ramos-Díaz
The advent of high-throughput sequencing technologies has revolutionized the way we understand the transformation of genetic information into morphological traits. Elucidating the network of interactions between genes that govern cell differentiation through development is one of the core challenges in genome research. These networks are known as developmental gene regulatory networks (dGRNs) and consist largely of the functional linkage between developmental control genes, cis-regulatory modules and differentiation genes, which generate spatially and temporally refined patterns of gene expression...
June 18, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29917053/echocardiographic-strain-analysis-for-the-early-detection-of-left-ventricular-systolic-diastolic-dysfunction-and-dyssynchrony-in-a-mouse-model-of-physiological-aging
#13
Claudio de Lucia, Markus Wallner, Deborah M Eaton, Huaqing Zhao, Steven R Houser, Walter J Koch
Heart disease is the leading cause of hospitalization and death worldwide, severely affecting health care costs. Aging is a significant risk factor for heart disease and the senescent heart is characterized by structural and functional changes including diastolic and systolic dysfunction as well as left ventricular (LV) dyssynchrony. Speckle-tracking based strain echocardiography (STE) has been shown as a non-invasive, reproducible and highly sensitive methodology to evaluate LV function in both animal models and humans...
June 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29917043/fins-as-mechanosensors-for-movement-and-touch-related-behaviors
#14
Brett R Aiello, Adam R Hardy, Mark W Westneat, Melina E Hale
Mechanosensation is a universal feature of animals that is essential for behavior, allowing detection of animals' own body movement and position as well as physical features of the environment. Fish fins provide a key vertebrate system for studying mechanosensation. The extraordinary morphological and behavioral diversity that exists across fish species provide rich opportunities for comparative mechanosensory studies in fins. The fins of fishes have been found to function as proprioceptors, by providing feedback on fin ray position and movement, and as tactile sensors, by encoding pressures applied to the fin surface...
June 18, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29917042/generation-and-primary-characterization-of-iam-1-a-versatile-new-line-of-conditionally-immortalized-atrial-myocytes-with-preserved-cardiomyogenic-differentiation-capacity
#15
Jia Liu, Linda Volkers, Wanchana Jangsangthong, Cindy I Bart, Marc C Engels, Guangqian Zhou, Martin J Schalij, Dirk L Ypey, Daniël A Pijnappels, Antoine A F de Vries
Aims: The generation of homogeneous cardiomyocyte populations from fresh tissue or stem cells is laborious and costly. A potential solution to this problem would be to establish lines of immortalized cardiomyocytes. However, as proliferation and (terminal) differentiation of cardiomyocytes are mutually exclusive processes, their permanent immortalization causes loss of electrical and mechanical functions. We therefore aimed at developing conditionally immortalized atrial myocyte (iAM) lines allowing toggling between proliferative and contractile phenotypes by a single-component change in culture medium composition...
June 18, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29917034/developments-in-toxicogenomics-understanding-and-predicting-compound-induced-toxicity-from-gene-expression-data
#16
REVIEW
Benjamin Alexander-Dann, Lavinia Lorena Pruteanu, Erin Oerton, Nitin Sharma, Ioana Berindan-Neagoe, Dezső Módos, Andreas Bender
The toxicogenomics field aims to understand and predict toxicity by using 'omics' data in order to study systems-level responses to compound treatments. In recent years there has been a rapid increase in publicly available toxicological and 'omics' data, particularly gene expression data, and a corresponding development of methods for its analysis. In this review, we summarize recent progress relating to the analysis of RNA-Seq and microarray data, review relevant databases, and highlight recent applications of toxicogenomics data for understanding and predicting compound toxicity...
June 19, 2018: Molecular omics
https://www.readbyqxmd.com/read/29916961/sense-and-sensibility-logical-approaches-to-profiling-in-animal-models
#17
Anthony H Dickenson, Ryan Patel
No abstract text is available yet for this article.
July 2018: Pain
https://www.readbyqxmd.com/read/29916863/parasympathetic-tone-activity-evaluation-to-discriminate-ketorolac-and-ketorolac-tramadol-analgesia-level-in-swine
#18
Carlos J Leitão, Juan Rafael Lima-Rodríguez, Fatima Ferreira, Catarina Avelino, Francisco M Sánchez-Margallo, Luís Antunes
BACKGROUND: Evaluation of nociceptive-antinociceptive balance during general anesthesia is still challenging and routinely based on clinical criteria. Analgesic drug delivered may be optimized with parasympathetic tone activity (PTA) monitor. This study compares ketorolac and ketorolac/tramadol balance analgesia using a PTA monitor. METHODS: Pain intensity response was assessed using a 0-100 numerical state scale (PTA) after nociceptive stimuli in pigs under stable sevoflurane anesthesia...
June 14, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29916803/genome-analysis-of-methicillin-resistance-in-macrococcus-caseolyticus-from-dairy-cattle-in-england-and-wales
#19
Alison C MacFadyen, Elizabeth A Fisher, Ben Costa, Cassie Cullen, Gavin K Paterson
Species of the genus Macrococcus are widespread commensals of animals but are becoming increasingly recognised as veterinary pathogens. They can encode methicillin resistance and are implicated in its spread to the closely-related, but more pathogenic, staphylococci. In this study we have identified 33 isolates of methicillin-resistant Macrococcus caseolyticus from bovine bulk tank milk from England and Wales. These isolates were characterised to provide insight into the molecular epidemiology of M. caseolyticus and to discern the genetic basis for their methicillin resistance...
June 19, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29916768/an-improved-rapid-competitive-elisa-using-a-novel-conserved-3b-epitope-for-the-detection-of-serum-antibodies-to-foot-and-mouth-disease-virus
#20
Chungwon J Chung, Alfonso Clavijo, Mangkey A Bounpheng, Sabena Uddowla, Abu Sayed, Brooke Dancho, Ian C Olesen, Juan Pacheco, Barbara J Kamicker, David A Brake, Carey L Bandaranayaka-Mudiyanselage, Stephen S Lee, Devendra K Rai, Elizabeth Rieder
The highly contagious foot-and-mouth disease virus (FMDV) afflicts cloven-hoofed animals, resulting in significant costs because of loss of trade and recovery from disease. We developed a sensitive, specific, and rapid competitive ELISA (cELISA) to detect serum antibodies to FMDV. The cELISA utilized a monoclonal blocking antibody specific for a highly conserved FMDV nonstructural 3B epitope, a recombinant mutant FMDV 3ABC coating protein, and optimized format variables including serum incubation for 90 min at 20-25°C...
June 1, 2018: Journal of Veterinary Diagnostic Investigation
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