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https://www.readbyqxmd.com/read/28822335/specificity-protein-1-modulated-superoxide-dismutase-2-enhances-temozolomide-resistance-in-glioblastoma-which-is-independent-of-o-6-methylguanine-dna-methyltransferase
#1
Kwang-Yu Chang, Tsung-I Hsu, Che-Chia Hsu, Shan-Yin Tsai, Jr-Jiun Liu, Shao-Wen Chou, Ming-Sheng Liu, Jing-Ping Liou, Chiung-Yuan Ko, Kai-Yun Chen, Jan-Jong Hung, Wen-Chang Chang, Cheng-Keng Chuang, Tzu-Jen Kao, Jian-Ying Chuang
Acquisition of temozolomide (TMZ) resistance is a major factor leading to the failure of glioblastoma (GBM) treatment. The exact mechanism by which GBM evades TMZ toxicity is not always related to the expression of the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT), and so remains unclear. In this study, TMZ-resistant variants derived from MGMT-negative GBM clinical samples and cell lines were studied, revealing there to be increased specificity protein 1 (Sp1) expression associated with reduced reactive oxygen species (ROS) accumulation following TMZ treatment...
August 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28822296/developmental-changes-in-the-mental-transformation-of-spatial-arrays
#2
Christos S Michaelides, Marios N Avraamides
An experiment was conducted to investigate the spatial memory and transformation of spatial relations in a sample of 7-, 9-, and 11-year-olds and to compare their performance with that of adults. Four pictures of animals were presented at different locations on the outline of a circle. Participants were instructed to memorize the array of locations and then, in a direct retrieval task, to reconstruct it from memory on a piece of paper that included only the circle outline. Then, in the transformation task, participants were asked to randomly place one of the animals at a new position around the circle and then to place the remaining three animals so that object-to-object locations were preserved...
August 16, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28822233/obese-fathers-lead-to-an-altered-metabolism-and-obesity-in-their-children-in-adulthood-review-of-experimental-and-human-studies
#3
REVIEW
Fernanda Ornellas, Priscila V Carapeto, Carlos A Mandarim-de-Lacerda, Marcia B Aguila
OBJECTIVE: To discuss the recent literature on paternal obesity, focusing on the possible mechanisms of transmission of the phenotypes from the father to the children. SOURCES: A non-systematic review in the PubMed database found few publications in which paternal obesity was implicated in the adverse transmission of characteristics to offspring. Specific articles on epigenetics were also evaluated. As the subject is recent and still controversial, all articles were considered regardless of year of publication...
August 16, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28822203/the-first-report-of-aelurostrongylus-falciformis-schlegel-1933-nematoda-metastrongyloidea-in-badger-meles-meles-in-poland
#4
Aleksander W Demiaszkiewicz, Katarzyna J Filip, Anna M Pyziel
Aelurostrongylus falciformis belongs to the superfamily of Metastrongyloidea. This nematode occurs in European badgers and locates in lungs, in respiratory tract. Numerous species of land snails are intermediate hosts of the parasite. In 2015, parasitological necropsy of 9 badgers, shot in the Forest District Głęboki Bród in Augustowska Primeval Forest, was performed. Two examined animals were infected with nematodes A. falciformis. In the lungs of each badger two specimens of nematodes were detected (male and female)...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28822174/-biological-assay-in-quality-control-of-animal-medicines
#5
REVIEW
Xuan Wang, Luo-Dan Ouyang, Chun-Mei Dai, Li Ma, Xiao-He Xiao
Animal medicine is a unique part of traditional Chinese medicine. They have strong effects, but their effective compounds are not entirely known. The efficiency and safety of animal medicines can't be effectively controlled by current quality assurance system and evaluation method, which has deeply influenced the development of animal medicines. Biological assay does not focus on efficacy of single component, but directly reflects the pharmacodynamics and safety of animal medicines by biological effect. With the development of biotechnology, many new technologies have emerged, such as biochip and high content analysis...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822091/effect-of-ap102-a-subtype-2-and-5-specific-somatostatin-analog-on-glucose-metabolism-in-rats
#6
Erika Tarasco, Petra Seebeck, Svende Pfundstein, Adrian F Daly, Philippe J Eugster, Alan G Harris, Eric Grouzmann, Thomas A Lutz, Christina N Boyle
PURPOSE: Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies...
August 18, 2017: Endocrine
https://www.readbyqxmd.com/read/28822066/do-evolutionary-changes-in-astrocytes-contribute-to-the-computational-power-of-the-hominid-brain
#7
Nancy Ann Oberheim Bush, Maiken Nedergaard
It is now well accepted that astrocytes are essential in all major nervous system functions of the rodent brain, including neurotransmission, energy metabolism, modulation of blood flow, ion and water homeostasis, and, indeed, higher cognitive functions, although the contribution of astrocytes in cognition is still in early stages of study. Here we review the most current research findings on human astrocytes, including their structure, molecular characterization, and functional properties. We also highlight novel tools that have been established for translational approaches to the comparative study of astrocytes from humans and experimental animals...
August 19, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28822057/short-term-exposure-to-enriched-environment-in-adult-rats-restores-mk-801-induced-cognitive-deficits-and-gabaergic-interneuron-immunoreactivity-loss
#8
Ane Murueta-Goyena, Naiara Ortuzar, Pascual Gargiulo, José Vicente Lafuente, Harkaitz Bengoetxea
Perinatal injections of N-methyl-D-aspartate (NMDA) receptor antagonist in rodents emulate some cognitive impairments and neurochemical alterations, such as decreased GABAergic (gamma aminobutyric acid) interneuron immunoreactivity, also found in schizophrenia. These features are pervasive, and developing neuroprotective or neurorestorative strategies is of special interest. In this work, we aimed to investigate if a short exposure to enriched environment (EE) in early adulthood (P55-P73) was an effective strategy to improve cognitive dysfunction and to restore interneuron expression in medial prefrontal cortex (mPFC) and hippocampus (HPC)...
August 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28821975/mixed-species-groups-of-animals-behavior-community-structure-and-conservation-by-eben-goodale-guy-beauchamp-graeme-ruxton-academic-press-2017-pp-xii%C3%A2-%C3%A2-203-paperback-isbn-9780128053553-ebook-isbn-9780128093054
#9
https://www.readbyqxmd.com/read/28821949/electromagnetically-navigated-in-situ-fenestration-of-aortic-stent-grafts-pilot-animal-study-of-a-novel-fenestrated-evar-approach
#10
Tobias Penzkofer, Hong-Sik Na, Peter Isfort, Christoph Wilkmann, Sabine Osterhues, Andreas Besting, Christoph Hänisch, Stefan Bisplinghoff, Johannes Jansing, Sylvie von Werder, Jorge Gooding, Mathias de la Fuente, Andreas H Mahnken, Catherine Disselhorst-Klug, Thomas Schmitz-Rode, Christiane Kuhl, Philipp Bruners
PURPOSE: Assess electromagnetically guided in situ fenestration of juxtarenal aortic stent grafts in an in vivo model. METHODS: Using a newly developed electromagnetic guidance system together with a modified, electromagnetically guidable catheter with steerable tip, an electromagnetically trackable guidewire and a custom in situ fenestrateable stent graft, a series of seven animal experiments was performed. In a swine model, stent grafts were placed juxtarenally, covering the renal arteries...
August 18, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28821879/musashi-1-enhances-glioblastoma-cell-migration-and-cytoskeletal-dynamics-through-translational-inhibition-of-tensin3
#11
Hsiao-Yun Chen, Liang-Ting Lin, Mong-Lien Wang, Benoit Laurent, Chih-Hung Hsu, Chih-Ming Pan, Wan-Ru Jiang, Pau-Yuan Chen, Hsin-I Ma, Yi-Wei Chen, Pin-I Huang, Arthur Chiou, Shih-Hwa Chiou
The RNA-binding protein Musashi-1 (MSI1) exerts essential roles in multiple cellular functions, such as maintenance of self-renewal and pluripotency of stem cells. MSI1 overexpression has been observed in several tumor tissues, including glioblastoma (GBM), and is considered as a well-established marker for tumor metastasis and recurrence. However, the molecular mechanisms by which MSI1 regulates cell migration are still undetermined. Here we reported that MSI1 alters cell morphology, promotes cell migration, and increases viscoelasticity of GBM cells...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821833/microrna-449c-5p-inhibits-osteogenic-differentiation-of-human-vics-through-smad4-mediated-pathway
#12
Rongjian Xu, Min Zhao, Yun Yang, Zhuo Huang, Chunying Shi, Xianglin Hou, Yannan Zhao, Bing Chen, Zhifeng Xiao, Jianzhou Liu, Qi Miao, Jianwu Dai
Calcific aortic valve disease (CAVD) is the most common heart valve disorder, yet its mechanism remains poorly understood. Valve interstitial cells (VICs) are the prevalent cells in aortic valve and their osteogenic differentiation may be responsible for calcific nodule formation in CAVD pathogenesis. Emerging evidence shows microRNA (miRNA, or miR) can function as important regulators of many pathological processes, including osteogenic differentiation. Here, we aimed to explore the function of miR-449c-5p in CAVD pathogenesis...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821830/disease-syndrome-combination-modeling-metabolomic-strategy-for-the-pathogenesis-of-chronic-kidney-disease
#13
Shasha Li, Peng Xu, Ling Han, Wei Mao, Yiming Wang, Guoan Luo, Nizhi Yang
Conventional disease animal models have limitations on the conformity to the actual clinical situation. Disease-syndrome combination (DS) modeling may provide a more efficient strategy for biomedicine research. Disease model and DS model of renal fibrosis in chronic kidney disease were established by ligating the left ureter and by ligating unilateral ureteral combined with exhaustive swimming, respectively. Serum metabolomics was conducted to evaluate disease model and DS model by using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821829/neuromodulatory-circuit-effects-on-drosophila-feeding-behaviour-and-metabolism
#14
Anders Eriksson, Marlena Raczkowska, Rapeechai Navawongse, Deepak Choudhury, James C Stewart, Yi Ling Tang, Zhiping Wang, Adam Claridge-Chang
Animals have evolved to maintain homeostasis in a changing external environment by adapting their internal metabolism and feeding behaviour. Metabolism and behaviour are coordinated by neuromodulation; a number of the implicated neuromodulatory systems are homologous between mammals and the vinegar fly, an important neurogenetic model. We investigated whether silencing fly neuromodulatory networks would elicit coordinated changes in feeding, behavioural activity and metabolism. We employed transgenic lines that allowed us to inhibit broad cellular sets of the dopaminergic, serotonergic, octopaminergic, tyraminergic and neuropeptide F systems...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821735/current-and-future-suitability-of-wintering-grounds-for-a-long-distance-migratory-raptor
#15
Christina Kassara, Laura Gangoso, Ugo Mellone, Gvido Piasevoli, Thomas G Hadjikyriakou, Nikos Tsiopelas, Sinos Giokas, Pascual López-López, Vicente Urios, Jordi Figuerola, Rafa Silva, Willem Bouten, Alexander N G Kirschel, Munir Z Virani, Wolfgang Fiedler, Peter Berthold, Marion Gschweng
Conservation of migratory species faces the challenge of understanding the ecological requirements of individuals living in two geographically separated regions. In some cases, the entire population of widely distributed species congregates at relatively small wintering areas and hence, these areas become a priority for the species' conservation. Satellite telemetry allows fine tracking of animal movements and distribution in those less known, often remote areas. Through integrating satellite and GPS data from five separated populations comprising most of the breeding range, we created a wide habitat suitability model for the Eleonora's falcon on its wintering grounds in Madagascar...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821732/light-color-importance-for-circadian-entrainment-in-a-diurnal-octodon-degus-and-a-nocturnal-rattus-norvegicus-rodent
#16
Maria Angeles Bonmati-Carrion, Beatriz Baño-Otalora, Juan Antonio Madrid, Maria Angeles Rol
The central circadian pacemaker (Suprachiasmatic Nuclei, SCN) maintains the phase relationship with the external world thanks to the light/dark cycle. Light intensity, spectra, and timing are important for SCN synchronisation. Exposure to blue-light at night leads to circadian misalignment that could be avoided by using less circadian-disruptive wavelengths. This study tests the capacity of a diurnal Octodon degus and nocturnal Rattus norvegicus to synchronise to different nocturnal lights. Animals were subjected to combined red-green-blue lights (RGB) during the day and to: darkness; red light (R); combined red-green LED (RG) lights; and combined red-green-violet LED (RGV) lights during the night...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821729/nonlinear-bayesian-filtering-and-learning-a-neuronal-dynamics-for-perception
#17
Anna Kutschireiter, Simone Carlo Surace, Henning Sprekeler, Jean-Pascal Pfister
The robust estimation of dynamical hidden features, such as the position of prey, based on sensory inputs is one of the hallmarks of perception. This dynamical estimation can be rigorously formulated by nonlinear Bayesian filtering theory. Recent experimental and behavioral studies have shown that animals' performance in many tasks is consistent with such a Bayesian statistical interpretation. However, it is presently unclear how a nonlinear Bayesian filter can be efficiently implemented in a network of neurons that satisfies some minimum constraints of biological plausibility...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821701/translational-medicine-for-the-benefit-of-people-and-animals
#18
C Wayne McIlwraith
No abstract text is available yet for this article.
August 19, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28821694/six-month-sentences-are-not-enough-for-cruelty-cases-say-animal-charities
#19
(no author information available yet)
No abstract text is available yet for this article.
August 19, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28821675/synergistic-toxicity-of-polyglutamine-expanded-tbp-in-glia-and-neuronal-cells-therapeutic-implications-for-sca17
#20
Yang Yang, Su Yang, Jifeng Guo, Yiting Cui, Baisha Tang, Xiao-Jiang Li, Shihua Li
Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. Although previous studies have demonstrated that expression of polyQ-expanded proteins in glial cells can cause neuronal injury via non-cell-autonomous mechanisms, these studies investigated animal models that overexpress transgenic mutant proteins. Since glial cells are particularly reactive to overexpressed mutant proteins, it is important to investigate the in vivo role of glial dysfunction in neurodegeneration when mutant polyQ proteins are endogenously expressed...
August 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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