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Lymphadenitis

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https://www.readbyqxmd.com/read/28516859/recombinant-esterase-from-corynebacterium-pseudotuberculosis-in-dna-and-subunit-recombinant-vaccines-partially-protects-mice-against-challenge
#1
Alexandre Antunes Brum, Andrea de Fatima Silva Rezende, Francisco Silvestre Brilhante, Thais Collares, Karine Begnine, Fabiana Kommling Seixas, Tiago Veiras Collares, Odir Antônio Dellagostin, Vasco Azevedo, Anderson Santos, Ricardo Wagner Portela, Sibele Borsuk
PURPOSE: We tested the efficacy of the esterase encoded by cp1002_RS09720 from Corynebacteriumpseudotuberculosis in recombinant subunit and DNA caseous lymphadenitis (CLA) vaccines. This target was predicted as one of the best CLA vaccine candidates by mature epitope density analysis. METHODOLOGY: Gene cp1002_RS09720 was cloned into two different vectors (pAE for subunit vaccine and pTARGET for DNA vaccine). Four groups of 15 mice each were immunized with the recombinant esterase rCP09720 associated with aluminium hydroxide adjuvant (G1), pTARGET/cp09720 DNA vaccine (G2), a naked pTARGET (G3) or PBS as a negative control (G4)...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28506054/-penile-tuberculosis-a-case-report
#2
Takahiro Imanaka, Hironori Nomura, Go Tsujimura, Yoko Ko, Takanori Kinjyo, Iwao Yoshioka, Shingo Takada, Yoko Yahata, Tetsu Mizutani
A 66-year-old man presented with a chief complaint of glans penis pain, induration, and discharge of pus. He was prescribed a course of antibiotics, but the condition persisted despite treatment. Thus, we differrentially diagnosed the patient with penile tuberculosis and pyoderma gangrenosum, and performed a biopsy of the penis. The biopsy result was thickening of the horny layer epidermis with only a foreign body granuloma composed of inflammatory cells, and did not lead to a definitive diagnosis. Thoraca-abdominal computed tomography revealed axillary lymphadenopathy with necrosis...
April 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28500949/human-health-risks-for-legionella-and-mycobacterium-avium-complex-mac-from-potable-and-non-potable-uses-of-roof-harvested-rainwater
#3
Kerry A Hamilton, Warish Ahmed, Simon Toze, Charles N Haas
A quantitative microbial risk assessment (QMRA) of opportunistic pathogens Legionella pneumophila (LP) and Mycobacterium avium complex (MAC) was undertaken for various uses of roof-harvested rainwater (RHRW) reported in Queensland, Australia to identify appropriate usages and guide risk management practices. Risks from inhalation of aerosols due to showering, swimming in pools topped up with RHRW, use of a garden hose, car washing, and toilet flushing with RHRW were considered for LP while both ingestion (drinking, produce consumption, and accidental ingestion from various activities) and inhalation risks were considered for MAC...
April 5, 2017: Water Research
https://www.readbyqxmd.com/read/28490385/alk-positive-anaplastic-large-cell-lymphoma-undiagnosed-in-a-patient-with-tuberculosis-a-case-report-and-review-of-the-literature
#4
Weerapat Owattanapanich, Pakpoom Phoompoung, Sanya Sukpanichnant
BACKGROUND: Due to a similarity between the features of lymphoma and the features of tuberculosis, lymphoma may go unrecognized and undiagnosed in patients with tuberculosis. CASE PRESENTATION: A 33-year-old Thai man presented to our center with typical clinical manifestations of tuberculous lymphadenitis, with negative tests for both acid-fast bacilli and fungi, and negative polymerase chain reaction for Mycobacterial tuberculosis complex. The disease was not responding to anti-tuberculosis treatment and he developed both pericardial effusion and progressive lymphadenopathy...
May 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28486739/-castleman-s-disease-a-case-series-of-a-rare-lymphoproliferative-disease
#5
Ricarda Riepl, Thomas Karl Hoffmann, Jens Greve
Castleman's disease is a very rare and potentially severe lymphoproliferative disorder. First sign may be cervical lymphadenitis, requiring sufficient support in diagnosis and therapy by an ENT specialist. Based on a case series the current manuscript gives an overview of the symptoms, the course of disease and the therapy options. Patients with the first diagnosis of a Castleman's disease at the ENT clinic of Ulm University during the years 2011-2015 were included. The duration of symptoms, the applied diagnostic and therapeutic algorithms were evaluated...
May 9, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28475618/first-time-detection-and-identification-of-the-mycobacterium-tuberculosis-complex-members-in-extrapulmonary-tuberculosis-clinical-samples-in-south-tunisia-by-a-single-tube-tetraplex-real-time-pcr-assay
#6
Mariam Siala, Salma Smaoui, Wafa Taktak, Salma Hachicha, Asma Ghorbel, Chema Marouane, Sana Kammoun, Dhikrayet Gamara, Leila Slim, Radhouane Gdoura, Férièle Messadi-Akrout
INTRODUCTION: Tunisia has one of the highest burdens of extrapulmonary tuberculosis (EPTB) among tuberculosis (TB) cases but the contribution of MTBC-mediated human EPTB is unknown. EPTB diagnosis is challenging due to the paucibacillary nature of clinical samples. Therefore, a need of a simplified molecular method for sensitive and specific TB detection and differentiation of MTBC members caused EPTB remains a priority to an early diagnosis, optimize successful anti-TB treatment and minimize transmission...
May 5, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28474649/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-diagnosing-mediastinal-lymphadenopathy
#7
Tanushree Gahlot, Ujjwal Parakh, Kusum Verma, Bobby Bhalotra, Neeraj Jain
CONTEXT: The diagnosis of mediastinal lymphadenopathy is always a challenge. There always a need of a technique that is highly accurate as well as safe for diagnosis the same. AIMS: The aim of the study is to assess the clinical usefulness and safety profile of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in diagnosing the patients with mediastinal lymphadenopathy. SETTINGS AND DESIGN: This was an observational prospective study...
May 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28471978/septicemia-and-pneumonia-due-to-mycobacterium-fortuitum-infection-in-a-patient-with-extronodal-nk-t-cell-lymphoma-nasal-type-a-case-report
#8
Jia Cong, Chenxi Wang, Li Ma, Shaoya Zhang, Jingwen Wang
RATIONALE: Mycobacterium fortuitum (M.fortuitum) is one of the rapidly growing nontuberculous mycobacterium (NTM) that is widespread in the environment. M.fortuitum can cause different types of disease including pulmonary disease, lymphadenitis, cutaneous disease, and disseminated disease. However, the infection presenting as septicemia is exceedingly rare. PATIENT CONCERNS: A 48-year-old immunocompromised male with extranodal NK/T-cell lymphoma, nasal type was admitted to the hospital because of high fever for 10 days...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28466800/-tularaemia-in-a-boy-following-participation-in-a-mud-race
#9
M Zijlstra, C C C Hulsker, E B Fanoy, R Pijnacker, A Kraaijeveld, M G J Koene, T F W Wolfs
BACKGROUND: Tularaemia is a rare disease. In Europe it mostly occurs in Scandinavia. Since 2011 more cases are being reported in the Netherlands. Tularaemia may manifest itself in various ways. It is important to take strict precautions during biopsy, drainage and biopsy processing in order to prevent transmission. CASE DESCRIPTION: A 10-year-old boy presented to the paediatrician with a left inguinal lymphadenitis. A week before the onset of symptoms he had participated in a children's mud race...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28458310/peripancreatic-tuberculous-lymphadenitis-diagnosed-via-endoscopic-ultrasound-guided-fine-needle-aspiration-and-polymerase-chain-reaction
#10
Jun Arai, Katsuya Kitamura, Akira Yamamiya, Yu Ishii, Tomohiro Nomoto, Tadashi Honma, Hiroo Ishida, Eisuke Shiozawa, Masafumi Takimoto, Hitoshi Yoshida
We performed endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) on a patient presenting with an asymptomatic peripancreatic mass-like lesion. The aspiration cytologic finding was class II. On positron emission tomography-computed tomography (PET-CT), there were hot spots in the left supra-clavicular lymph node and the peripancreatic lesion. A whole biopsy of the left supra-clavicular lymph node revealed tuberculous lymphadenitis. Polymerase chain reaction (PCR) using tissue obtained via EUS-FNA showed that the peripancreatic mass-like lesion was also positive for tuberculosis...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28437431/factors-associated-with-acquired-anti-ifn-%C3%AE-autoantibody-in-patients-with-nontuberculous-mycobacterial-infection
#11
Pakpoom Phoompoung, Nasikarn Ankasekwinai, Manop Pithukpakorn, Suporn Foongladda, Pinklow Umrod, Bhoom Suktitipat, Surakameth Mahasirimongkol, Sasisopin Kiertiburanakul, Yupin Suputtamongkol
BACKGROUND: The clinical syndrome of disseminated nontuberculous mycobacterial (NTM) infection in patients who were previously healthy is now well recognized to be associated with an acquired autoantibody to Interferon gamma (Anti IFN- γ autoantibody). However, the risk factors of this syndrome remain unknown. METHOD: We performed an unmatched case control study among patients with NTM diseases who were diagnosed and treated at Siriraj Hospital, Bangkok, Thailand...
2017: PloS One
https://www.readbyqxmd.com/read/28428301/whole-genome-sequence-of-corynebacterium-pseudotuberculosis-pa04-isolated-from-the-lymph-node-of-a-sheep-in-the-amazon-brazil
#12
Wana L O Costa, Jorianne T C Alves, Larissa M Dias, Carlos Leonardo de Aragão Araújo, Eziquiel Morais, André G M Silva, Soraya S Andrade, Rommel T J Ramos, Artur Silva, Adriana R C Folador
This study reports the complete genome sequence of Corynebacterium pseudotuberculosis strain PA04, isolated from a sheep in the Amazon, Brazil. This bacterium is the etiological agent of caseous lymphadenitis. This genome contains 2,338,093 bp, 52.2% G+C content, and a total of 2,104 coding sequences (CDSs), 41 pseudogenes, 12 rRNAs, and 49 tRNAs.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28428297/complete-genome-sequence-of-mycobacterium-avium-subsp-hominissuis-strain-h87-isolated-from-an-indoor-water-sample
#13
Xueyan Zhao, L Elaine Epperson, Nabeeh A Hasan, Jennifer R Honda, Edward D Chan, Michael Strong, Nicholas D Walter, Rebecca M Davidson
Mycobacterium avium subsp. hominissuis is an environmentally acquired bacterium known to cause pulmonary and soft tissue infections, lymphadenitis, and disseminated disease in humans. We report here the complete genome sequence of strain H87, isolated from an indoor water sample, as a single circular chromosome of 5,626,623 bp with a G+C content of 68.8%.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28425207/bcg-vaccination-induced-suppurative-lymphadenitis-four-signs-to-pay-attention-to
#14
Sang Oon Baek, Hyo Sun Ko, Hyun Ho Han
Suppurative lymphadenitis is one of the severe complication after BCG vaccination, but its diagnostic criteria and treatment guidelines have not yet been established. In this article, we describe a case of suppurative lymphadenitis caused by BCG vaccination and propose diagnostic criteria and treatment guidelines of the disease. The lymphadenitis was presented as skin involving mass and was completely extirpated. Pathological evaluation revealed a necrotising lymphadenitis, consistent with the diagnosis of BCG lymphadenitis...
April 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28415732/additional-k-ras-mutation-analysis-and-plectin-1-staining-improve-the-diagnostic-accuracy-of-pancreatic-solid-mass-in-eus-guided-fine-needle-aspiration
#15
Joo Kyung Park, Woo Hyun Paik, Byeong Jun Song, Ji Kon Ryu, Min A Kim, Jin Myung Park, Sang Hyub Lee, Yong-Tae Kim
BACKGROUND: One of the major genetic alterations in pancreatic ductal adenocarcinoma (PDAC) is the point mutation of K-ras gene. Plectin-1 was also recently identified as PDAC specific biomarker. The aim of this study was to investigate the improvement of diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) by using additional K-ras mutation analysis and Plectin-1 staining in patients with pancreatic mass. METHODS: A total of 85 study patients with pancreatic mass underwent EUS-FNA and the final diagnoses were as follows; PDACs: 70 patients, pancreas neuroendocrine tumor: 4, metastasis to pancreas: 5, autoimmune pancreatitis: 3, chronic pancreatitis: 1, tuberculous lymphadenitis: 1, pseudocyst: 1...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413722/performance-of-interferon-%C3%AE-release-assay-in-the-diagnosis-of-tuberculous-lymphadenitis-a-meta-analysis
#16
Qianqian Liu, Wenzhang Li, Yunfeng Chen, Xinmiao Du, Chengdi Wang, Binmiao Liang, Yin Tang, Yulin Feng, Chuanmin Tao, Jian-Qing He
BACKGROUND: The diagnostic values of interferon-gamma release assays (IGRA) in tuberculosis (TB) vary a lot with different site of infections, with especially higher sensitivities in chronic forms of TB such as tuberculosis of the lymph node. We conducted a meta-analysis to comprehensively evaluate the overall accuracy of diagnostic IGRA for tuberculous lymphadenitis. METHODS: Pubmed, Web of Science, EMBASE, Wanfang and CNKI databases up to February 17, 2017 were searched to identify published studies...
2017: PeerJ
https://www.readbyqxmd.com/read/28397313/correlation-of-cytologic-and-histopathologic-findings-with-perinodal-echogenicity-of-abdominal-lymph-nodes-in-dogs-and-cats
#17
Aditya C Davé, Lisa J Zekas, Danelle M Auld
Abdominal lymphadenopathy in dogs and cats is routinely investigated with ultrasound. As the determination between benign and neoplastic etiologies of lymphadenopathy affects patient management, specific sonographic characteristics associated with both benign and neoplastic lymph nodes have been suggested. However, a significant overlap between these characteristics exists, necessitating a cytologic or histopathologic diagnosis in most instances. The objectives of this retrospective, cross-sectional study were to evaluate whether echogenicity of perinodal fat could be a discriminator between benign and neoplastic abdominal lymphadenopathy and to assess if additional sonographic features associated with malignancy could be identified in lymph nodes with hyperechoic perinodal fat...
April 11, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28392823/etiology-and-clinical-characteristics-of-fever-of-unknown-origin-in-children-a-15-year-experience-in-a-single-center
#18
Yi-Seul Kim, Kyung-Ran Kim, Ji-Man Kang, Jong-Min Kim, Yae-Jean Kim
PURPOSE: Fever is one of the most common symptoms in children. In previous studies, infectious disease was the most common cause of pediatric fever of unknown origin (FUO). The aim of this study is to investigate the etiology, clinical characteristics and prognosis of pediatric FUO in 21 century with more diagnostics available and to analyze the factors for certain disease categories. METHODS: Among the children under 18 years old who were hospitalized at Samsung Medical Center from January 2000 to December 2014, the patients who met the criteria including fever of ≥38...
March 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28390621/evaluation-of-an-imaging-protocol-using-ultrasound-as-the-primary-diagnostic-modality-in-pediatric-patients-with-superficial-soft-tissue-infections-of-the-face-and-neck
#19
Rishabh Sethia, Justin B Mahida, Rahul A Subbarayan, Katherine J Deans, Peter C Minneci, Charles A Elmaraghy, Garth F Essig
OBJECTIVE: To determine the clinical impact of an initiative to use ultrasound (US) as the primary diagnostic modality for children with superficial face and neck infections versus use of computed tomography (CT). METHODS: Children with a diagnosis of lymphadenitis, face or neck abscess, or face and neck cellulitis were retrospectively evaluated by the otolaryngology service. Patients were separated into two groups based on implementation of a departmental initiative to use US as the primary diagnostic modality...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28387146/pinpointing-the-source-of-infection-of-mycobacterium-avium-hominissuis-in-children
#20
Johanna Thegerström
Mycobacterium avium hominissuis is the most important causative agent of chronic nontuberculous lymphadenitis in children. Despite a ubiquitous occurrence of the bacteria in the environment, the disease is a rare entity, and so far no source of infection has been formally identified. The current state of knowledge regarding possible sources of M. avium hominissuis, especially where children are concerned, is summarized here. An analysis of the seasonal variation of M. avium lymphadenitis in children leads to a new hypothesis regarding the probable source of infection of M...
April 7, 2017: Infectious Diseases
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