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Chronic lung disease

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https://www.readbyqxmd.com/read/29908494/protective-effect-of-exogenous-hydrogen-sulfide-on-pulmonary-artery-endothelial-cells-by-suppressing-endoplasmic-reticulum-stress-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#1
Hai-Bo Ding, Kai-Xiong Liu, Jie-Feng Huang, Da-Wen Wu, Jun-Ying Chen, Qing-Shi Chen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a multicomponent disorder characterized by inflammation, representing a significant leading cause of chronic morbidity and mortality. Reports have implicated hydrogen sulfide (H2 S) in both the pathology and treatment of COPD. The present study aimed to explore the effects involved with exogenous H2 S on endoplasmic reticulum stress (ERS) and pulmonary artery endothelial cells (PAECs) in a rat model of COPD. METHODS: Rat models of COPD were successfully established by means of passive smoke exposure and intratracheal injection with lipopolysaccharide (LPS)...
June 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29908291/tumor-necrosis-factor-%C3%AE-interleukin-8-and-eosinophil-cationic-protein-as-serum-markers-of-glucocorticoid-efficacy-in-the-treatment-of-bronchial-asthma
#2
Jing Ren, Yong Sun, Gang Li, Xiao-Jue Zhu, Jin-Guo Cui
BACKGROUND: Bronchial asthma (BA) is a common chronic respiratory disease that has exhibited a rising global incidence in recent years. Glucocorticoids are used for the treatment of BA. Emerging evidence has demonstrated the roles of tumor necrosis factor (TNF-α), interleukin-8 (IL-8) and eosinophil cationic protein (ECP) in BA. The present study investigated whether TNF-α, IL-8 and ECP were associated with the clinical stages and severity of BA and the efficacy of glucocorticoids in the treatment of BA...
June 13, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29907298/the-role-of-exosomes-in-allograft-immunity
#3
REVIEW
Sandhya Bansal, Monal Sharma, Ranjithkumar R, T Mohanakumar
Extracellular vesicles are emerging as potent vehicles of intercellular communication. In this review, we focus on a subclass of extracellular vesicles called exosomes. Previously considered an unimportant catch-all, exosomes have recently been recognized for their role in various diseases and their potential for therapeutic use. We have examined the role of exosomes after human lung transplantation and have delineated the composition of circulating exosomes isolated from lung transplant recipients diagnosed with acute and chronic rejection, primary graft dysfunction, and respiratory viral infection...
June 7, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29907106/activation-and-polarization-of-circulating-monocytes-in-severe-chronic-obstructive-pulmonary-disease
#4
William D Cornwell, Victor Kim, Xiaoxuan Fan, Marie Elena Vega, Frederick V Ramsey, Gerard J Criner, Thomas J Rogers
BACKGROUND: The ability of circulating monocytes to develop into lung macrophages and promote lung tissue damage depends upon their phenotypic pattern of differentiation and activation. Whether this phenotypic pattern varies with COPD severity is unknown. Here we characterize the activation and differentiation status of circulating monocytes in patients with moderate vs. severe COPD. METHODS: Blood monocytes were isolated from normal non-smokers (14), current smokers (13), patients with moderate (9), and severe COPD (11)...
June 15, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29906503/isolation-and-profiling-of-plasma-micrornas-biomarkers-for-asthma-and-allergic-rhinitis
#5
Ronaldo P Panganiban, Kristin A Lambert, Man-Hsun Hsu, Zoe Laryea, Faoud T Ishmael
Chronic inflammatory diseases can be particularly challenging to diagnose and characterize, as inflammatory changes in tissue may not be present in blood. There is a crucial need to develop non-invasive biomarkers that would be useful in diagnosing disease and selecting medical therapies. For example, there are no blood tests to diagnose asthma, a common inflammatory lung disease. MicroRNA (miRNA) expression profiling in blood is emerging as a potentially sensitive and useful biomarker of many diseases. In particular, we have characterized a cost-effective PCR-based array technology to measure and profile circulating miRNAs in the plasma of patients with allergic rhinitis and asthma...
June 12, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29906421/effectiveness-of-pulmonary-rehabilitation-in-patients-with-chronic-obstructive-pulmonary-disease-with-different-degrees-of-static-lung-hyperinflation
#6
Michiel J E G W Vanfleteren, Maud Koopman, Martijn A Spruit, Herman-Jan Pennings, Frank Smeenk, Willem Pieters, Jan J A M van den Bergh, Arent-Jan Michels, Emiel F M Wouters, Miriam T J Groenen, Frits M E Franssen, Lowie E G W Vanfleteren
OBJECTIVE: To evaluate the effect of pulmonary rehabilitation (PR) on exercise performance and quality of life in patients with chronic obstructive pulmonary disease (COPD) with different degrees of static lung hyperinflation (LH). DESIGN: Retrospective cohort study. SETTING: Pulmonary Rehabilitation Network. PARTICIPANTS: A cohort of 1981 patients with COPD (55% males; age: 66.8 ± 9.3y; FEV1%: 50.7 ± 19.5; RV%: 163...
June 12, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29906247/a-critical-role-for-abc-transporters-in-persistent-lung-inflammation-in-the-development-of-emphysema-after-smoke-exposure
#7
Jarrod Sonett, Monica Goldklang, Piotr Sklepkiewicz, Adam Gerber, Jordis Trischler, Tina Zelonina, Marit Westerterp, Vincent Lemaître, Yasunori Okada, Jeanine D'Armiento
Macrophage infiltration is common to both emphysema and atherosclerosis, and cigarette smoke down-regulates the macrophage cholesterol efflux transporter ATP binding cassette (ABC)A1. This decreased cholesterol efflux results in lipid-laden macrophages. We hypothesize that cigarette smoke adversely affects cholesterol transport via an ABCA1-dependent mechanism in macrophages, enhancing TLR4/myeloid differentiation primary response gene 88 (Myd88) signaling and resulting in matrix metalloproteinase (MMP) up-regulation and exacerbation of pulmonary inflammation...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29904593/case-report-pulmonary-and-liver-sarcoidosis-suspected-of-metastasis
#8
Behnam Jafari, Gholamabas Sabz, Elahe Masnavi, Roghaye Panahi, Saeid Jokar, Amrollah Roozbehi, Sajad Hasanzadeh
Introduction : Sarcoidosis is a granulomatous disease with unknown cause that can vary from an asymptomatic condition. Almost half of the patients with sarcoidosis have no symptoms. In this article, we describe a sarcoidosis patient with lung and liver engagement; it may be confused with metastasis. Case report : A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment...
2018: F1000Research
https://www.readbyqxmd.com/read/29904584/new-targets-for-resolution-of-airway-remodeling-in-obstructive-lung-diseases
#9
REVIEW
Ajay P Nayak, Deepak A Deshpande, Raymond B Penn
Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). The pathology manifests itself in the form of significant, progressive, and (to date) seemingly irreversible changes to distinct respiratory structural compartments. Consequently, AR correlates with disease severity and the gradual decline in pulmonary function associated with asthma and COPD. Although current asthma/COPD drugs manage airway contraction and inflammation, none of these effectively prevent or reverse features of AR...
2018: F1000Research
https://www.readbyqxmd.com/read/29904014/is-it-time-to-change-the-definition-of-acute-exacerbation-of-chronic-obstructive-pulmornary-disease-what-do-we-need-to-add
#10
REVIEW
Maria Montes de Oca, Maria Eugenia Laucho-Contreras
Acute exacerbations in chronic obstructive pulmonary disease (AECOPD) are associated with increased mortality, rate of hospitalization, use of healthcare resources, and have a negative impact on disease progression, quality of life and lung function of patients with chronic obstructive pulmonary disease (COPD). There is an imperative need to homogenize the definition of AECOPD because the incidence of exacerbations has a significant influence or implication on treatment decision making, particularly in pharmacotherapy and could impact the outcome or change the statistical significance of a therapeutic intervention in clinical trials...
June 14, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29903859/how-to-build-a-lung-latest-advances-and-emerging-themes-in-lung-bioengineering
#11
Martina M De Santis, Deniz A Bölükbas, Sandra Lindstedt, Darcy E Wagner
Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation...
June 14, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29903700/feasibility-of-using-a-smartwatch-to-intensively-monitor-patients-with-chronic-obstructive-pulmonary-disease-prospective-cohort-study
#12
Robert Wu, Daniyal Liaqat, Eyal de Lara, Tatiana Son, Frank Rudzicz, Hisham Alshaer, Pegah Abed-Esfahani, Andrea S Gershon
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated decline in lung function, diminished quality of life, and higher mortality. Proactively monitoring patients for early signs of an exacerbation and treating them early could prevent these outcomes. The emergence of affordable wearable technology allows for nearly continuous monitoring of heart rate and physical activity as well as recording of audio which can detect features such as coughing...
June 14, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29903047/bone-marrow-characterization-in-copd-a-multi-level-network-analysis
#13
Nuria Toledo-Pons, Guillaume Noell, Andreas Jahn, Amanda Iglesias, Maria Antonia Duran, Julio Iglesias, Angel Rios, Sergio Scrimini, Rosa Faner, Orlando Gigirey, Alvar Agustí, Borja G Cosío
BACKGROUND: Bone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by defective lung repair. Yet, BM composition has not been previously characterized in COPD patients. METHODS: In this prospective and controlled study, BM was obtained by sternum fine-needle aspiration in 35 COPD patients and 25 healthy controls (10 smokers and 15 never-smokers)...
June 15, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29902554/resource-use-during-the-last-6-months-of-life-among-copd-patients-a-population-level-study
#14
Kristof Faes, Joachim Cohen, Lieven Annemans
CONTEXT: Chronic obstructive pulmonary disease (COPD) patients often have several comorbidities, such as cardiovascular diseases (CVD) or lung cancer (LC), which might influence resource use in the final months of life. However, no previous studies documented resource use in end-of-life COPD patients at a population level, thereby differentiating whether COPD patients die of their COPD, CVD or LC. AIM: To describe end-of-life resource use in people diagnosed with COPD and compare this resource use between those dying of COPD, CVD and LC...
June 11, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29902195/theoretical-open-loop-model-of-respiratory-mechanics-in-the-extremely-preterm-infant
#15
Laura Ellwein Fix, Joseph Khoury, Russell R Moores, Lauren Linkous, Matthew Brandes, Henry J Rozycki
Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to their markedly increased chest wall compliance that does not provide enough structure against which the forces of inhalation can generate sufficient pressure. To address the continued challenge of studying treatments in this fragile population, we developed a nonlinear lumped-parameter respiratory system mechanics model of the extremely preterm infant that incorporates nonlinear lung and chest wall compliances and lung volume parameters tuned to this population...
2018: PloS One
https://www.readbyqxmd.com/read/29901735/contribution-of-chronic-conditions-to-smoking-differences-in-life-expectancy-with-and-without-disability-in-belgium
#16
Renata T C Yokota, Willma J Nusselder, Jean-Marie Robine, Jean Tafforeau, Rana Charafeddine, Lydia Gisle, Patrick Deboosere, Herman Van Oyen
Background: Smoking is the leading cause of premature mortality and morbidity. This study aimed at assessing the impact of smoking on life expectancy (LE) and LE with (LED) and without disability (DFLE). We further estimated the contribution of disability and mortality and their causes to differences in LED and DFLE by smoking. Methods: Data on disability, chronic conditions, and smoking from 17 148 participants of the 1997, 2001, 2004 Belgian Health Interview Surveys were used to estimate causes of disability using the attribution method...
June 12, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29901644/hepatic-actinomycosis-with-immunoglobulin-g4-related-liver-disease-a-case-report
#17
Joo Hyung Lee, Hyung Sun Kim, Ji Sub Kim, Dong Ki Lee, Jin Hong Lim
RATIONALE: Immunoglobulin (Ig)G4-related pseudotumors of the liver are very rare diseases that are difficult to distinguish from malignant tumors. They can be usually improved by steroid therapy. Actinomycosis is a chronic, suppurative, granulomatous infection, for which immune suppression is a predisposing factor. It can also mimic malignant tumors. PATIENT CONCERNS: A 67-year-old man presented with mild abdominal discomfort and a 5-kg weight loss for 3 months...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901531/safety-of-electromagnetic-navigation-bronchoscopy-in-patients-with-copd-results-from-the-navigate-study
#18
Christopher W Towe, Michael A Nead, Otis B Rickman, Erik E Folch, Sandeep J Khandhar, Yaron Perry, Philip A Linden
BACKGROUND: Electromagnetic navigation bronchoscopy (ENB) aids in the localization of lung lesions for biopsy and/or to guide fiducial or dye marking for stereotactic radiation or surgical localization. This study assessed ENB safety in patients with chronic obstructive pulmonary disease (COPD) and/or poor lung function. METHODS: NAVIGATE is a prospective, multicenter, observational study of ENB. This substudy analyzed the 1-month follow-up of the first 1000 enrolled subjects...
June 12, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29899396/lung-cellular-senescence-is-independent-of-aging-in-a-mouse-model-of-copd-emphysema
#19
Kahkashan Rashid, Isaac K Sundar, Janice Gerloff, Dongmei Li, Irfan Rahman
Cigarette smoke (CS) induces lung cellular senescence that plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). How aging influences cellular senescence and other molecular hallmarks, and increases the risk of CS-induced damage remains unknown. We hypothesized that aging-associated changes in lungs worsen the COPD/emphysema by CS exposure. Younger and older groups of C57BL/6J mice were exposed to chronic CS for 6 months with respective age-matched air-exposed controls...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898744/osm-potentiates-preintravasation-events-increases-ctc-counts-and-promotes-breast-cancer-metastasis-to-the-lung
#20
Ken Tawara, Celeste Bolin, Jordan Koncinsky, Sujatha Kadaba, Hunter Covert, Caleb Sutherland, Laura Bond, Joseph Kronz, Joel R Garbow, Cheryl L Jorcyk
BACKGROUND: Systemic and chronic inflammatory conditions in patients with breast cancer have been associated with reduced patient survival and increased breast cancer aggressiveness. This paper characterizes the role of an inflammatory cytokine, oncostatin M (OSM), in the preintravasation aspects of breast cancer metastasis. METHODS: OSM expression levels in human breast cancer tissue samples were assessed using tissue microarrays, and expression patterns based on clinical stage were assessed...
June 14, 2018: Breast Cancer Research: BCR
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