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Hariharasudan Mani, Alisha Hossain, Elsie Lee, Muhammad Rizvi
Small bowel malignancies are relatively rare, accounting for only 3% of all gastrointestinal cancers. Duodenum is the most common location among small bowel cancers, followed by Jejunum and then Ileum. Duodenal adenocarcinoma produces vague symptoms, leading to late presentation and a poor prognosis compared to similarly staged colon cancer. It is rare to have brain metastasis in duodenal adenocarcinoma, and not many case reports have been reported. Only approximately 6% of patients with gastrointestinal malignancy have brain metastasis...
February 2024: Curēus
#22
JOURNAL ARTICLE
Azusa Yamamoto, Toru Ishiguro, Tetsuya Ito, Yoshitaka Toyomasu, Yoichi Kumagai, Erito Mochiki, Chiaki Murakami, Hiroki Imada, Junichi Tamaru, Shigehisa Inokuma, Hideyuki Ishida
A 28-year-old female with a history of treatment for small intestinal polyps and characteristic pigmentation of her lip was clinically diagnosed with Peutz-Jeghers syndrome(PJS). Her sister had the pathogenic variant of STK11 upon genetic testing. A 20-mm polyp was identified in the second part the patient's duodenum on routine gastrointestinal surveillance, and biopsy revealed a well-differentiated adenocarcinoma. Laparoscopic partial duodenectomy with endoscopy was planned. After confirming the location of the tumor and Kocherization using a laparoscope, the polyp was resected via submucosal dissection under direct visualization with a small incision...
March 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#23
Panagiotis Armonis, Jeffrey Leung, Charles Murray, Alberto Murino
No abstract text is available yet for this article.
March 2024: Frontline Gastroenterology
#24
Taiyo Hirata, Shinya Kawaguchi, Taisuke Akamatsu, Atsuko Inagawa, Tomoki Hikichi, Kohei Ohkawa, Kazuhisa Asahara, Tatsunori Satoh, Shinya Endo, Makoto Suzuki, Kazuya Ohno
INTRODUCTION: Solid organ malignancies rarely metastasize to the duodenal papilla. We describe a case of primary lung cancer with duodenal papillary metastasis in a patient who presented with melena. To the best of our knowledge, this is only the second report of duodenal papillary metastasis from lung cancer. CASE PRESENTATION: A 65-year-old woman presented with complaints of anorexia, weight loss, and black stool. Imaging studies led to a clinical diagnosis of stage IVB lung cancer, and anticoagulants were initiated to treat pulmonary artery thrombosis...
2024: Case Reports in Gastroenterology
#25
JOURNAL ARTICLE
Joana Lemos Garcia, Isadora Rosa, João Pereira da Silva, Pedro Lage, Isabel Claro
INTRODUCTION: Over 90% of the patients with familial adenomatous polyposis (FAP) will develop duodenal adenomas. AIM: The aim of this study was to evaluate the effectiveness and safety of endoscopic excision of large duodenal adenomas in FAP patients. METHODS: All FAP patients from a familial risk clinic submitted to endoscopic therapy for duodenal adenomas ≥10 mm between January 2010 and February 2021 were included. RESULTS: From 151 FAP families, 22 patients (50 lesions) were included: 54...
December 2023: GE Portuguese Journal of Gastroenterology
#26
JOURNAL ARTICLE
Bas A Uijterwijk, Daniël H Lemmers, Giuseppe Kito Fusai, Bas Groot Koerkamp, Sharnice Koek, Alessandro Zerbi, Ernesto Sparrelid, Ugo Boggi, Misha Luyer, Benedetto Ielpo, Roberto Salvia, Brian K P Goh, Geert Kazemier, Bergthor Björnsson, Mario Serradilla-Martín, Michele Mazzola, Vasileios K Mavroeidis, Santiago Sánchez-Cabús, Patrick Pessaux, Steven White, Adnan Alseidi, Raffaele Dalla Valle, Dimitris Korkolis, Louisa R Bolm, Zahir Soonawalla, Keith J Roberts, Miljana Vladimirov, Alessandro Mazzotta, Jorg Kleeff, Miguel Angel Suarez Muñoz, Marc G Besselink, Mohammed Abu Hilal
This international multicenter cohort study included 30 centers. Patients with duodenal adenocarcinoma (DAC), intestinal-type (AmpIT) and pancreatobiliary-type (AmpPB) ampullary adenocarcinoma, distal cholangiocarcinoma (dCCA), and pancreatic ductal adenocarcinoma (PDAC) were included. The primary outcome was 30-day or in-hospital mortality, and secondary outcomes were major morbidity (Clavien-Dindo 3b≥), clinically relevant post-operative pancreatic fistula (CR-POPF), and length of hospital stay (LOS)...
February 23, 2024: Cancers
#27
JOURNAL ARTICLE
Dong Hyun Kim, Seon Young Park, Jin Won Kim, Hyun Soo Kim
Gastric cancer, a leading cause of cancer-related deaths globally, necessitates effective and early detection and treatment strategies. Endoscopic resection techniques, particularly endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), have evolved significantly, enhancing the treatment of gastric neoplasms. Underwater endoscopic mucosal resection (UEMR) is a widely used technique for the resection of duodenal and colorectal neoplasms. However, the feasibility and efficacy of UEMR in the stomach are not well established...
March 3, 2024: Diagnostics
#28
Justin Ferkin, Brooke Williams, Phillip S Moore
Lung adenocarcinoma, the predominant subtype of non-small cell lung cancer, typically metastasizes to common sites such as the liver and adrenal glands. However, rare instances involve skeletal muscle metastasis. We present a case of a 45-year-old female with a medical history of hypertension, epilepsy, and fibromyalgia, who presented to the emergency department with hemoptysis and multifocal pain. Chest imaging revealed a cavitary lesion which appeared to be necrotizing pneumonia. Further investigations uncovered a fluid collection in the left thigh, which would be identified as poorly differentiated carcinoma...
February 2024: Curēus
#29
JOURNAL ARTICLE
Takashi Komatsubara, Koji Fujimoto, Hideaki Miyabe, Yuma Tanigawa, Wataru Kumode, Eisei Mitsuoka, Tetsuo Maeda, Masayuki Ishii
Primary carcinoma of the duodenum, especially mucinous carcinoma of the duodenum, is extremely rare. We present a case of a long-term response to chemotherapy in mucinous carcinoma of the duodenum with multiple distant metastases. A 60-year-old man was admitted to our hospital with epigastric pain and jaundice. CT showed a thickening of the duodenal wall; extensive lymphadenopathy around the head of the pancreas, in the para-aortic region and the mediastinum; suspected peritoneal dissemination; lung metastases; and bone metastases...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#30
Dinesh Abhijeeth Shanker, Sampath Kumar, Ahmed Al-Mukhtar, Asha Dube, Nehemiah Samuel
Gastrointestinal stromal tumours (GISTs) are rare gastrointestinal (GI) malignancies, but the most prevalent mesenchymal tumours of the GI tract arise from the interstitial cells of Cajal. They account for 1-3% of all GI malignancies, and only 3-5% of all cases of GIST are located at the duodenal. We present a case of a young adult who presented to the ED with symptoms of GI bleeding.
January 2024: Curēus
#31
JOURNAL ARTICLE
Zhengchun Zhu, Hong Liu, Fei Zhong
BACKGROUND AND OBJECTIVES: Duodenal adenocarcinoma (DAC) is a rare tumor that is often accompanied by liver metastasis in advanced stages. The aim of this study was to evaluate the correlation between clinicopathological characteristics and survival in DAC patients with liver metastasis, and to explore appropriate treatment options. METHODS: 482 DAC patients with liver metastasis were retrospectively identified from the Surveillance, Epidemiology and End Results (SEER) database (2011-2020)...
2024: Clinical and Experimental Gastroenterology
#32
JOURNAL ARTICLE
Takashi Taniguchi, Noboru Ideno, Tomoyuki Araki, Shun Miura, Masahiro Yamamoto, Tomoki Nakafusa, Nobuhiro Higashijima, Takeo Yamamoto, Koji Tamura, So Nakamura, Toshiya Abe, Naoki Ikenaga, Kohei Nakata, Kenoki Ohuchida, Yoshinao Oda, Takao Ohtsuka, Masafumi Nakamura
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate owing to its late diagnosis and aggression. In addition, there are relatively few minimally invasive screening methods for the early detection of PDAC, making the identification of biomarkers for this disease a critical priority. Recent studies have reported that microRNAs in extracellular vesicles (EV-miRs) from bodily fluids can be useful for the diagnosis of PDACs. Given this, we designed this study to evaluate the utility of cancer EVs extracted from duodenal fluid (DF) and their resident EV-miRs as potential biomarkers for the detection of PDAC...
April 2024:
#33
Billy Zhao, Hyun Jae Kim, Landon Tam, Wei Xiong, Greg Rosenfeld
Gastric extranodal NK/T-cell lymphoma (ENKTL) is a rare presentation of a rare disease. We report a 33-year-old woman presenting with epigastric pain, nausea, and vomiting. Endoscopic examination revealed gastric and duodenal ulceration. Biopsy of the ulcers revealed ENKTL. The patient began treatment, but developed hemorrhagic shock from her ulcers and died. Gastric ENKTL is a rare disease that presents with gastric ulceration. It has a high rate of mortality, and treatment is challenging because of its aggressive nature and lack of high-quality data to guide therapy...
March 2024: ACG Case Reports Journal
#34
JOURNAL ARTICLE
Giuseppe Vanella, Giuseppe Dell'Anna, Agostino Cosenza, Federica Pedica, Maria Chiara Petrone, Alberto Mariani, Livia Archibugi, Gemma Rossi, Matteo Tacelli, Piera Zaccari, Roberto Leone, Domenico Tamburrino, Giulio Belfiori, Massimo Falconi, Luca Aldrighetti, Michele Reni, Andrea Casadei Gardini, Claudio Doglioni, Gabriele Capurso, Paolo Giorgio Arcidiacono
Background and study aims Besides increasing adequacy, rapid on-site evaluation (ROSE) during endoscopic ultrasound (EUS) or endoscopic retrograde cholangiopancreatography (ERCP) may impact choices and timing of subsequent therapeutic procedures, yet has been unexplored. Patients and methods This was a retrospective evaluation of a prospectively maintained database of a tertiary, academic centre with availability of ROSE and hybrid EUS-ERCP suites. All consecutive patients referred for pathological confirmation of suspected malignancy and jaundice or gastric outlet obstruction (GOO) between Jan-2020 and Sep-2022 were included...
February 2024: Endoscopy International Open
#35
JOURNAL ARTICLE
Hiroyuki Shibata, Kenta Yamamoto, Takashi Hirose, Satoshi Furune, Naomi Kakushima, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Mitsuhiro Fujishiro, Hiroki Kawashima
INTRODUCTION: Nonampullary duodenal epithelial tumors are rare, but their prevalence is increasing. Various gastrointestinal cancers have been associated with microbiomes. We evaluated the characteristics of the salivary and duodenal microbiomes of patients with nonampullary duodenal epithelial tumors. METHODS: Saliva and biopsy samples from the duodenal bulb and descending portion were obtained from 15 patients with nonampullary duodenal epithelial tumors and 10 controls...
February 26, 2024: Digestive and Liver Disease
#36
JOURNAL ARTICLE
Ken Yamashita, Shiro Oka, Takeshi Yamada, Keigo Mitsui, Hironori Yamamoto, Keiichi Takahashi, Akio Shiomi, Kinichi Hotta, Yoji Takeuchi, Toshio Kuwai, Fumio Ishida, Shin-Ei Kudo, Shoichi Saito, Masashi Ueno, Eiji Sunami, Tomoki Yamano, Michio Itabashi, Kazuo Ohtsuka, Yusuke Kinugasa, Takayuki Matsumoto, Tamotsu Sugai, Toshio Uraoka, Koichi Kurahara, Shigeki Yamaguchi, Tomohiro Kato, Masazumi Okajima, Hiroshi Kashida, Yoshito Akagi, Hiroaki Ikematsu, Masaaki Ito, Motohiro Esaki, Masaya Kawai, Takashi Yao, Madoka Hamada, Takahiro Horimatsu, Keiji Koda, Yasumori Fukai, Koji Komori, Yusuke Saitoh, Yukihide Kanemitsu, Hiroyuki Takamaru, Kazutaka Yamada, Hiroaki Nozawa, Tetsuji Takayama, Kazutomo Togashi, Eiji Shinto, Takehiro Torisu, Akira Toyoshima, Naoki Ohmiya, Takeshi Kato, Eigo Otsuji, Shinji Nagata, Yojiro Hashiguchi, Kenichi Sugihara, Yoichi Ajioka, Shinji Tanaka
BACKGROUND: The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, remain undetermined due to its rarity in Japan. METHODS: We analyzed 354 patients with 358 PSBAs, between January 2008 and December 2017, at 44 institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum. RESULTS: The median age was 67 years (218 males, 61.6%). The average tumor size was 49...
February 27, 2024: Journal of Gastroenterology
#37
JOURNAL ARTICLE
Irene A Caspers, Ellis L Eikenboom, Marta Lopez-Yurda, Nicole C T van Grieken, Tanya M Bisseling, Evelien Dekker, Barbara A J Bastiaansen, Annemieke Cats, Monique E van Leerdam
BACKGROUND: Lynch syndrome increases the risk of gastric cancer (GC) and duodenal cancer (DC), particularly in individuals with MLH1 and MSH2 pathogenic variants (PVs). To provide further insight into whether, and from what age, esophagogastroduodenoscopy (EGD) surveillance may be beneficial, we evaluated the cumulative incidence and tumour characteristics of GC and DC in a large nationwide cohort of Dutch individuals with LS. METHODS: For this retrospective nationwide cohort study, clinical data of individuals with LS registered at the Dutch Hereditary Cancer Registry were matched with pathology reports filed by the Dutch Pathology registry...
March 2024: EClinicalMedicine
#38
REVIEW
Katarzyna Smolarczyk, Blazej Meczekalski, Ewa Rudnicka, Katarzyna Suchta, Anna Szeliga
Obesity and obesity-related conditions today constitute a public health problem worldwide. Obesity is an "epidemic" chronic disorder, which is defined by the WHO as normal or excessive fat accumulation that may impair health. It is also defined for adults as a BMI that is greater than or equal to 30. The most common obesity-related diseases are type 2 diabetes mellitus, cardiovascular diseases, metabolic syndrome, chronic kidney disease, hyperlipidemia, hypertension, nonalcoholic fatty liver disease, and certain types of cancer...
February 14, 2024: Medicina
#39
JOURNAL ARTICLE
Maria Cristina Conti Bellocchi, Enrico Gasparini, Serena Stigliano, Daryl Ramai, Laura Bernardoni, Francesco Maria Di Matteo, Antonio Facciorusso, Luca Frulloni, Stefano Francesco Crinò
BACKGROUND: Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) using lumen apposing metal stent has emerged as a minimally invasive treatment for the management of malignant gastric outlet obstruction (mGOO). We aimed to compare EUS-GE with enteral stenting (ES) for the treatment of mGOO. METHODS: Patients who underwent EUS-GE or ES for mGOO between June 2017 and June 2023 at two Italian centers were retrospectively identified. The primary outcome was stent dysfunction...
February 8, 2024: Cancers
#40
JOURNAL ARTICLE
Pedro Wong-Salgado, Fabiano Soares, Jeel Moya-Salazar, José F Ramírez-Méndez, Marcia M Moya-Salazar, Alfonso Apesteguía, Americo Castro
Cannabis is a plant that is cultivated worldwide, and its use is internationally regulated, but some countries have been regulating its medicinal, social, and industrial uses. This plant must have arrived in Peru during the Spanish conquest and remains widely cultivated illicitly or informally to this day. However, new regulations are currently being proposed to allow its legal commercialization for medicinal purposes. Cannabis contains specific metabolites known as cannabinoids, some of which have clinically demonstrated therapeutic effects...
January 29, 2024: Biomedicines
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