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https://www.readbyqxmd.com/read/29786691/prognosis-and-nomogram-for-predicting-postoperative-survival-of-duodenal-adenocarcinoma-a-retrospective-study-in-china-and-the-seer-database
#1
Sujing Jiang, Rongjie Zhao, Yiran Li, Xufeng Han, Zhen Liu, Weiting Ge, Ying Dong, Weidong Han
As primary duodenal adenocarcinoma is rare, the prognostic factors of this disease remain insufficiently explored, especially in China. We identified postoperative duodenal adenocarcinoma patients at a Chinese double-center (from 2006 to 2016) or who were registered with the Surveillance, Epidemiology, and End Results (SEER) database (from 2004 to 2014). Clinicopathological features and significant prognostic factors for cancer-specific survival (CSS) were reviewed and analyzed by using univariate and multivariate Cox proportional hazards regression...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29774937/-application-of-robotic-surgery-to-treat-carcinoma-in-the-remnant-stomach
#2
Feng Qian, Jiajia Liu, Junyan Liu, Junyan Fan, Yongliang Zhao, Yan Shi, Yingxue Hao, Peiwu Yu
OBJECTIVE: To explore the surgical techniques and feasibility of robotic surgery for carcinoma in the remnant stomach(CRS). METHODS: Clinicopathological data of 20 CRS patients undergoing robotic surgery at the Minimally Invasive Center for Gastrointestinal Surgery, Army Medical University Southwest Hospital from November 2012 to October 2017 were retrospectively collected. The surgical methods, procedures, main difficulties, and key techniques were analyzed, and the clinical efficacy was evaluated...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774929/-epidemiological-characteristics-and-inducing-factors-of-gastric-stump-cancer
#3
Lin Chen
Gastric stump cancer was initially defined as a carcinoma of the stomach occurring more than 5 years after surgery for gastric or duodenal benign disease. In recent years, as the number of total gastrectomy for benign disease has gradually decreased and the gastric cancer detection and operation rate have annually increased, residual recurrence of primary gastric cancer more than 10 years after gastric cancer surgery has also been considered as gastric stump cancer. The incidence of gastric stump cancer is increasing annually...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29764299/efficacy-of-sufficient-operation-view-by-ring-shaped-thread-counter-traction-for-safer-duodenal-esd
#4
Yasuhiro Goda, Hirohito Mori, Hideki Kobara, Tsutomu Masaki
BACKGROUND: Duodenal ESD is considered especially difficult with perforation and bleeding. This study assessed safer duodenal ESD procedures, especially with regard to obtaining a good operation view using a ring-thread method and closure of a post-ESD artificial ulcer. METHODS: From 2013 to 2015, 17 patients who were diagnosed with duodenal adenoma or early duodenal cancer >20 mm in diameter underwent conventional ESD (C group). From 2016 to 2017, 12 patients underwent ring-shaped thread counter traction ESD with hemoclips and/or Over-The-Scope Clip (OTSC) (Ovesco Endoscopy GmbH, Tuebingen, Germany) closure of post ESD artificial ulcer (ring group)...
May 15, 2018: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29763988/adjusting-the-length-and-direction-of-the-redundant-duodenal-stent-using-a-detachable-snare-and-endoclips
#5
Takashi Sasaki, Toshiyuki Yoshio, Junko Fujisaki
A 43-year-old woman with advanced gastric cancer was presented with gastric outlet obstruction. Duodenal stent (WallFlex duodenal soft 22mm x 12cm, Boston Scientific, Japan) was deployed to cover the stricture between antrum and 2nd part of duodenum. The stent did not expand fully because of the tight stricture even after balloon dilation. The stent became longer than expected which caused the kinking at the stomach (Figure 1). This article is protected by copyright. All rights reserved.
May 15, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29760541/laparoscopic-gastrojejunostomy-for-gastric-outlet-obstruction-in-patients-with-unresectable-hepatopancreatobiliary-cancers-a-personal-series-and-systematic-review-of-the-literature
#6
REVIEW
Alba Manuel-Vázquez, Raquel Latorre-Fragua, Carmen Ramiro-Pérez, Aylhin López-Marcano, Roberto De la Plaza-Llamas, José Manuel Ramia
The major symptoms of advanced hepatopancreatic-biliary cancer are biliary obstruction, pain and gastric outlet obstruction (GOO). For obstructive jaundice, surgical treatment should de consider in recurrent stent complications. The role of surgery for pain relief is marginal nowadays. On the last, there is no consensus for treatment of malignant GOO. Endoscopic duodenal stents are associated with shorter length of stay and faster relief to oral intake with more recurrent symptoms. Surgical gastrojejunostomy shows better long-term results and lower re-intervention rates, but there are limited data about laparoscopic approach...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29753623/endoscopic-duodenal-stent-versus-surgical-gastrojejunostomy-for-gastric-outlet-obstruction-in-patients-with-advanced-pancreatic-cancer
#7
Shinya Uemura, Takuji Iwashita, Keisuke Iwata, Tsuyoshi Mukai, Shinji Osada, Takafumi Sekino, Takahito Adachi, Masahiko Kawai, Ichiro Yasuda, Masahito Shimizu
BACKGROUND: Malignant gastric outlet obstruction (GOO) often develops in patients with advanced pancreatic cancer (APC). It is not clear whether endoscopic duodenal stenting (DS) or surgical gastrojejunostomy (GJJ) is preferable as palliative treatment. AIMS: To compare the efficacy and safety of GJJ and DS for GOO with APC. METHODS: Consecutive 99 patients who underwent DS or GJJ for GOO with APC were evaluated. We compared the technical and clinical success rates, the incidence of adverse event (AE), the time to start chemotherapy and discharge and survival durations between DS and GJJ...
May 3, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29743338/helicobacter-pylori-biofilm-formation-and-its-potential-role-in-pathogenesis
#8
REVIEW
Skander Hathroubi, Stephanie L Servetas, Ian Windham, D Scott Merrell, Karen M Ottemann
Despite decades of effort, Helicobacter pylori infections remain difficult to treat. Over half of the world's population is infected by H. pylori , which is a major cause of duodenal and gastric ulcers as well as gastric cancer. During chronic infection, H. pylori localizes within the gastric mucosal layer, including deep within invaginations called glands; thanks to its impressive ability to survive despite the harsh acidic environment, it can persist for the host's lifetime. This ability to survive and persist in the stomach is associated with urease production, chemotactic motility, and the ability to adapt to the fluctuating environment...
June 2018: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/29736661/abdominal-drainage-and-amylase-measurement-for-detection-of-leakage-after-gastrectomy-for-gastric-cancer
#9
Judith P M Schots, Misha D P Luyer, Grard A P Nieuwenhuijzen
PURPOSE: To investigate the value of daily measurement of drain amylase for detecting leakage in gastric cancer surgery. METHODS: This was a retrospective analysis including all patients who underwent a gastrectomy for gastric cancer. From January 2013 until December 2015, an intra-abdominal drain was routinely placed. Drain amylase was measured daily. Receiver operator characteristic curves were created to assess the ability of amylase to predict leakage. Sensitivity, specificity, and negative and positive predictive value of amylase in drain fluid were determined...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29731265/mir-21-up-regulation-in-ampullary-adenocarcinoma-and-its-pre-invasive-lesions
#10
Deborah Saraggi, Francesca Galuppini, Giuseppe N Fanelli, Andrea Remo, Emanuele D L Urso, Ricardo Q Bao, Deborah Bacchin, Vincenza Guzzardo, Claudio Luchini, Chiara Braconi, Fabio Farinati, Massimo Rugge, Matteo Fassan
Poor information is available on the molecular landscape characterizing the carcinogenetic process leading to ampullary carcinoma. MiR-21 is one of the most frequently up-regulated miRNAs in pancreatic adenocarcinoma, a tumor sharing similar molecular features with ampullary adenocarcinomas (AVCs), above all with the pancreatic-biliary type. We profiled, by in situ hybridization (ISH), miR-21 expression in a series of 26 AVCs, 50 ampullary dysplastic lesions (35 low-grade [LG-IEN] and 15 high-grade [HG-IEN]) and 10 normal duodenal mucosa samples...
May 1, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29724301/-clinical-value-of-multi-slice-spiral-enhanced-ct-in-diagnosing-mild-digestive-tract-hemorrhage
#11
Xiao Ling Wen, Li Wang, Xiao Qin Song, Zhi Zhang, Xiao Fang Zhu, Shao Ping Wu
Objective To investigate the clinical value of multi-slice spiral CT(MSCT) in the diagnosis of mild digestive tract hemorrhage. Methods Thirty-five patients with mild gastrointestinal hemorrhage were examined by enhanced MSCT.CT signs were observed and compared with pathologic examination findings.Results Diseases in these 35 patients included gastric and duodenal ulcer and inflammation(n=4,11.4%),esophagogastric variceal rupture(n=7,20.0%),gastric carcinoma(n=3,8.6%),gastric stromal tumor(n=3,8.6%),gastric polyp(n=1,2...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29716579/laterally-spreading-tumour-of-the-distal-stomach-a-case-report
#12
Samiullah Khan, Lan-Ping Zhu, Yujie Zhang, Xin Chen, Bang-Mao Wang
BACKGROUND: Laterally spreading tumours (LSTs) are superficial neoplasms that usually extend laterally along the intra-luminal wall of the gastrointestinal tract. Recently, the incidence of LSTs in the colorectal mucosa has greatly increased. However, LSTs in the stomach are exceedingly rare and have never been previously reported. CASE PRESENTATION: Here, we report a 69-year-old male with epigastric pain and a gastric LST 6 cm in diameter located in the distal stomach and grossly extended into the duodenal bulb...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29702101/the-impact-of-chromoendoscopy-for-surveillance-of-the-duodenum-in-patients-with-mutyh-associated-polyposis-and-familial-adenomatous-polyposis
#13
Joanna J Hurley, Laura E Thomas, Sarah-Jane Walton, Siwan Thomas-Gibson, Adam Haycock, Noriko Suzuki, Matthew Mort, Geraint Williams, Meleri Morgan, Susan K Clark, Julian R Sampson, Sunil Dolwani
BACKGROUND AND AIMS: Duodenal polyposis and cancer have become a key issue for patients with familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP). Almost all patients with FAP will develop duodenal adenomas, with 5% developing cancer. The incidence of duodenal adenomas in MAP appears to be lower than in FAP but the limited available data suggest a comparable increase in the relative risk and lifetime risk of duodenal cancer. Current surveillance recommendations, however, are the same for FAP and MAP, using the Spigelman score--incorporating polyp number, size, dysplasia, and histology--for risk stratification and determination of surveillance intervals...
April 24, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29680252/demonstration-of-safety-and-feasibility-of-hydrogel-marking-of-the-pancreas-duodenum-interface-for-image-guided-radiation-therapy-igrt-in-a-porcine-model-implications-in-igrt-for-pancreatic-cancer-patients
#14
Avani D Rao, Eun Ji Shin, Sarah E Beck, Caroline Garrett, Seong-Hun Kim, Nam Ju Lee, Eleni Liapi, John Wong, Joseph Herman, Amol Narang, Kai Ding
PURPOSE: To test the feasibility and safety of injecting a high-contrast hydrogel marker at the head of the pancreas (HOP) and duodenum interface and assesses the marker visibility on cone beam computed tomography (CBCT) to localize this important boundary during image guided radiation therapy in a porcine model. METHODS AND MATERIALS: This was a 2-stage study. The feasibility/visibility stage evaluated the ability to place the hydrogel using endoscopic ultrasound guidance on 8 swine (4 euthanized at post-injection day 8, 4 euthanized at post-injection day 22) and assessed the quality of visibility of the marked location on CBCT in the longer-surviving group...
March 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29662006/hyperinsulinemia-promotes-esophageal-cancer-development-in-a-surgically-induced-duodeno-esophageal-reflux-murine-model
#15
Diletta Arcidiacono, Arben Dedja, Cinzia Giacometti, Matteo Fassan, Daniele Nucci, Simona Francia, Federico Fabris, Alice Zaramella, Emily J Gallagher, Mauro Cassaro, Massimo Rugge, Derek LeRoith, Alfredo Alberti, Stefano Realdon
Hyperinsulinemia could have a role in the growing incidence of esophageal adenocarcinoma (EAC) and its pre-cancerous lesion, Barrett's Esophagus, a possible consequence of Gastro-Esophageal Reflux Disease. Obesity is known to mediate esophageal carcinogenesis through different mechanisms including insulin-resistance leading to hyperinsulinemia, which may mediate cancer progression via the insulin/insulin-like growth factor axis. We used the hyperinsulinemic non-obese FVB/N (Friend leukemia virus B strain) MKR (muscle (M)-IGF1R-lysine (K)-arginine (R) mouse model to evaluate the exclusive role of hyperinsulinemia in the pathogenesis of EAC related to duodeno-esophageal reflux...
April 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29653246/duodenal-fistula-the-most-lethal-surgical-complication-in-a-case-series-of-radical-gastrectomy
#16
Marcus Fernando Kodama Pertille Ramos, Marina Alessandra Pereira, Leandro Cardoso Barchi, Osmar Kenji Yagi, Andre Roncon Dias, Daniel Szor, Bruno Zilberstein, Ulysses Ribeiro-Júnior, Ivan Cecconello
BACKGROUND: Despite all advances regarding the surgical treatment of gastric cancer (GC), duodenal stump fistula (DF) continues to negatively affect postoperative outcomes. This study aimed to assess DF regarding its incidence, risk factors, management and impact on overall survival. METHODS: We retrospectively analyzed 562 consecutive patients who underwent gastrectomy for GC between 2009 and 2017. Clinicopathological characteristics analysis was performed comparing DF, other surgical fistulas and patients with uneventful postoperative course...
April 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29650915/-a-case-of-primary-duodenal-cancer-with-duodenocolic-fistula-treated-with-pancreatoduodenectomy-and-right-hemicolectomy
#17
Hideo Ota, Shigekazu Yokoyama, Eri Tanaka, Shigeto Nakai, Nobuo Takiguchi, Shoko Honda, Ryohei Yukimoto, Shinji Tokuyama, Akina Saito, Tomohira Takeoka, Hiroshi Matsuno, Ken Konishi, Kazuyuki Okada, Mutsumi Fukunaga, Kenji Kobayashi
A patient was 59-year-old female. She presented our hospital with weight loss, anorexia and lower abdominal bloating. Abdominal computed tomography(CT), gastrointestinal endoscopy, colonoscopy and duodenal fistulagram showed duodenal cancer or colon cancer with duodenocolic fistula and ovary metastasis. She underwent subtotal stomach preserving pancreatoduodenectomy and right hemicolectomy. In these pathological findings, tumor was diagnosed as a duodenal cancer with duodenocolic fistula. She was surviving 12 months after the last surgery...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650845/-a-case-report-of-sox-treatment-for-primary-duodenal-carcinoma-with-liver-metastasis
#18
Yuki Yokota, Hirotsugu Nagase, Kozo Noguchi, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Yoshito Tomimaru, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Keizo Dono
We report a case of effective S-1 plus oxaliplatin (SOX) treatment for duodenal cancer with liver metastases. The patient was a 70-year-old female diagnosed with duodenal carcinoma that was unresectable because of liver metastasis(cT4N1M1, cStage IV in UICC 7th). She received SOX treatment(100mg/m / 2 of oxaliplatin on day 1 combined with 40 mg/day of S-1 twice daily on days 1-14, was repeated every 3 weeks). After 4 courses, a partial response was confirmed by computed tomography and no severe adverse events were observed...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29629218/safety-of-laparoscopic-sentinel-basin-dissection-in-patients-with-gastric-cancer-an-analysis-from-the-senorita-prospective-multicenter-quality-control-trial
#19
Ji Yeong An, Jae Seok Min, Young Joon Lee, Sang Ho Jeong, Hoon Hur, Sang Uk Han, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park, Mi Ran Jung, Ji Yeon Park, Young Woo Kim, Hong Man Yoon, Bang Wool Eom, Keun Won Ryu
Purpose: We investigated complications after laparoscopic sentinel basin dissection (SBD) for patients with gastric cancer who were enrolled in a quality control study, prior to the phase III trial of sentinel lymph node navigation surgery (SNNS). Materials and Methods: We analyzed prospective data from a Korean multicenter prerequisite quality control trial of laparoscopic SBD for gastric cancer and assessed procedure-related and surgical complications. All complications were classified according to the Clavien-Dindo Classification (CDC) system and were compared with the results of the previously published SNNS trial...
March 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29595684/gastric-metastasis-from-invasive-lobular-breast-cancer-mimicking-primary-gastric-cancer-a-case-report
#20
Dae Hoon Kim, Seung-Myoung Son, Young Jin Choi
RATIONALE: Gastric metastasis from invasive lobular breast cancer is relatively rare, commonly presented among multiple metastases, several years after primary diagnosis of breast cancer. Importantly, gastric cancer that is synchronously presented with lobular breast cancer can be misdiagnosed as primary gastric cancer; therefore, accurate differential diagnosis is required. PATIENT CONCERNS: A 39-year-old woman was visited to our hospital because of right breast mass and progressive dyspepsia...
March 2018: Medicine (Baltimore)
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