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https://www.readbyqxmd.com/read/29761331/folfirinox-versus-gemcitabine-nab-paclitaxel-for-neoadjuvant-treatment-of-resectable-and-borderline-resectable-pancreatic-head-adenocarcinoma
#1
Mashaal Dhir, Mazen S Zenati, Ahmad Hamad, Aatur D Singhi, Nathan Bahary, Melissa E Hogg, Herbert J Zeh, Amer H Zureikat
BACKGROUND: Both FOLFIRINOX and gemcitabine/nab-paclitaxel (G-nP) are used increasingly in the neoadjuvant treatment (NAT) of pancreatic ductal adenocarcinoma (PDA). This study aimed to compare neoadjuvant FOLFIRINOX and G-nP in the treatment of resectable (R) and borderline resectable (BR) head PDA. METHODS: A single-institution retrospective review of R and BR patients undergoing pancreaticoduodenectomy after NAT with FOLFIRINOX or G-nP was performed. Comparative analysis was performed using inverse-probability-weighted (IPW) estimators...
May 14, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29754673/prevalent-digoxin-use-and-subsequent-risk-of-death-or-hospitalization-in-ambulatory-heart-failure-patients-with-a-reduced-ejection-fraction-findings-from-the-heart-failure-a-controlled-trial-investigating-outcomes-of-exercise-training-hf-action-randomized-controlled
#2
Andrew P Ambrosy, Ankeet S Bhatt, Amanda L Stebbins, Lisa M Wruck, Marat Fudim, Stephen J Greene, William E Kraus, Christopher M O'Connor, Ileana L Piña, David J Whellan, Robert J Mentz
BACKGROUND: Despite more than 200 years of clinical experience and a pivotal trial, recently published research has called into question the safety and efficacy of digoxin therapy in heart failure (HF). METHODS: HF-ACTION (ClinicalTrials.gov Number: NCT00047437) enrolled 2331 outpatients with HF and an EF ≤35% between April 2003 and February 2007 and randomized them to aerobic exercise training versus usual care. Patients were grouped according to prevalent digoxin status at baseline...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29736850/contralateral-parenchymal-enhancement-on-dynamic-contrast-enhanced-mri-reproduces-as-a-biomarker-of-survival-in-er-positive-her2-negative-breast-cancer-patients
#3
Bas H M van der Velden, Elizabeth J Sutton, Luca A Carbonaro, Ruud M Pijnappel, Elizabeth A Morris, Kenneth G A Gilhuijs
OBJECTIVES: To assess whether contralateral parenchymal enhancement reproduces as an independent biomarker for patient survival in an independent patient cohort from a different cancer institution. METHODS: This is a HIPAA-compliant IRB approved retrospective study. Patients with ER-positive/HER2-negative operable invasive ductal carcinoma and preoperative dynamic contrast-enhanced MRI were consecutively included between 2005 and 2009. The parenchyma of the breast contralateral to known cancer was segmented automatically on MRI and contralateral parenchymal enhancement (CPE) was calculated...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29731541/introduction-to-double-robust-methods-for-incomplete-data
#4
Shaun R Seaman, Stijn Vansteelandt
Most methods for handling incomplete data can be broadly classified as inverse probability weighting (IPW) strategies or imputation strategies. The former model the occurrence of incomplete data; the latter, the distribution of the missing variables given observed variables in each missingness pattern. Imputation strategies are typically more efficient, but they can involve extrapolation, which is difficult to diagnose and can lead to large bias. Double robust (DR) methods combine the two approaches. They are typically more efficient than IPW and more robust to model misspecification than imputation...
2018: Statistical Science: a Review Journal of the Institute of Mathematical Statistics
https://www.readbyqxmd.com/read/29707092/improved-outcomes-associated-with-the-use-of-intravenous-acetaminophen-for-management-of-acute-post-surgical-pain-in-cesarean-sections-and-hysterectomies
#5
Richard D Urman, Elaine A Boing, An T Pham, Victor Khangulov, Randi Fain, Brian H Nathanson, Xuan Zhang, George J Wan, Belinda Lovelace, Jessica Cirillo
Background: Post-surgical pain impacts many patient outcomes. Effective pain management increasingly relies on multimodal analgesia regimens in which acetaminophen (APAP) is a key component. The aim of our study was to examine the impact of oral APAP versus intravenous (IV) APAP as a component of post-surgical pain management after Cesarean sections and hysterectomies. Methods: A retrospective analysis of the Cerner HealthFacts® database (from January, 2011 to December, 2015) was conducted to compare outcomes of Cesarean section and hysterectomy surgery patients who received oral APAP to those who received IV APAP post-surgically...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29701335/survival-after-bilateral-internal-mammary-artery-in-coronary-artery-bypass-grafting-are-women-at-risk
#6
Francisca A Saraiva, Nicolas Girerd, Rui J Cerqueira, João P Ferreira, Noélia Vilas-Boas, Paulo Pinho, António Barros, Mário J Amorim, André Lourenço, Adelino F Leite-Moreira
INTRODUCTION: To compare survival and safety of BIMA versus SIMA CABG between males and females at our tertiary care center. METHODS: Single-center retrospective cohort including consecutive patients with at least 2 left coronary system (LCS) vessel disease who underwent isolated CABG with at least 1 IMA conduit and a minimum of 2 conduits targeting the LCS between 2004 and 2013. All-cause mortality was the primary outcome, secondary outcomes were in-hospital mortality and reoperation due to sternal wound complications (SWC)...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29669426/do-coffee-farmers-benefit-in-food-security-from-participating-in-coffee-cooperatives-evidence-from-southwest-ethiopia-coffee-cooperatives
#7
Zekarias Shumeta, Marijke D'Haese
BACKGROUND: Most coffee in Ethiopia is produced by smallholder farmers who face a daily struggle to get sufficient income but also to feed their families. At the same time, many smallholder coffee producers are members of cooperatives. Yet, literature has paid little attention to the effect of cooperatives on combating food insecurity among cash crop producers including coffee farmers. OBJECTIVE: The objective of the study was to investigate how coffee cooperative membership may affect food security among coffee farm households in Southwest Ethiopia...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29610007/conventional-joa-score-for-cervical-myelopathy-has-a-rater-s-bias-in-comparison-with-joacmeq
#8
Noboru Hosono, Shota Takenaka, Yoshihiro Mukai, Kosuke Tateishi, Yasushi Fujiwara, Yuichiro Morishita, Hiroaki Konishi
BACKGROUND: The JOA (Japan Orthopaedic Association) score has been a standard outcome measure to evaluate cervical myelopathy in Japan. Despite its reliability and convenience, there can be a rating bias in the JOA score. The current study was conducted to delineate the rater's bias of the JOA score by comparing it with a new objective outcome measure. METHODS: Two hundred and thirty four operative candidates with cervical myelopathy were included in the study. The patients were divided into four groups according to the surgeon (92 patients in group A, 60 patients in group B, 38 patients in group C and 44 patients in group D)...
March 30, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29584868/antiretroviral-therapy-and-mortality-in-rural-south-africa-a-comparison-of-causal-modeling-approaches
#9
Catherine E Oldenburg, George R Seage, Frank Tanser, Victor De Gruttola, Kenneth H Mayer, Matthew J Mimiaga, Jacob Bor, Till Bärnighausen
Estimation of causal effects from observational data is a primary goal of epidemiology. The use of multiple methods with different assumptions relating to exchangeability improves causal inference by demonstrating robustness across assumptions. We estimate the effect of antiretroviral therapy (ART) on mortality in rural KwaZulu-Natal, South Africa from 2007-2011 using two methods with substantially different assumptions: the regression discontinuity design (RDD), and inverse probability weighting of marginal structural models (IPW)...
March 23, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29584560/impact-of-medicaid-managed-care-on-illinois-s-acute-health-services-expenditures-for-adults-with-intellectual-and-developmental-disabilities
#10
Kiyoshi Yamaki, Coady Wing, Dale Mitchell, Randall Owen, Tamar Heller
States have increasingly transitioned Medicaid enrollees with disabilities from fee-for-service (FFS) to Medicaid Managed Care (MMC), intending to reduce state Medicaid spending and to provide better access to health services. Yet, previous studies on the impact of MMC are limited and findings are inconsistent. We analyzed the impact of MMC on costs by tracking Illinois's Medicaid acute health services expenditures for adults with intellectual and developmental disabilities (IDD) living in the community ( n = 1,216) before and after their transition to MMC...
April 2018: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29517516/hybrid-coronary-revascularization-versus-percutaneous-strategies-in-left-main-stenosis-a-propensity-match-study
#11
Alberto Repossini, Lorenzo Di Bacco, Fabrizio Rosati, Maurizio Tespili, Antonio Saino, Alfonso Ielasi, Claudio Muneretto
AIMS: Hybrid revascularization (HCR) has been recently proposed as an alternative strategy in multivessel coronary disease, particularly in patients with high SYNTAX scores and risk scores. The objective of this study is to evaluate the outcomes of HCR versus percutaneous coronary intervention (PCI) drug-eluting stenting in left main treatment. METHODS: A series of 198 consecutive patients with left main stenosis have been treated. HCR, was performed in 77 patients (G1) whereas 121 patients (G2) received PCI on left main...
May 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29515213/impact-of-orthotic-therapy-for-improving-activities-of-daily-living-in-individuals-with-spinal-cord-injury-a-retrospective-cohort-study
#12
Takuya Hada, Ryo Momosaki, Masahiro Abo
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To determine the impact of leg orthotic therapy for improving activities of daily living after spinal cord injury. SETTING: Participating acute care and rehabilitation hospitals across Japan. METHODS: We retrospectively identified individuals with spinal cord injury admitted to eight participating hospitals in 2015-2016 from the Japan Rehabilitation Database. Data for 293 individuals were analyzed...
March 7, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29463119/effects-of-exposure-to-the-communities-that-care-prevention-system-on-youth-problem-behaviors-in-a-community-randomized-trial-employing-an-inverse-probability-weighting-approach
#13
Isaac C Rhew, Sabrina Oesterle, Donna Coffman, J David Hawkins
Earlier intention-to-treat (ITT) findings from a community-randomized trial demonstrated effects of the Communities That Care (CTC) prevention system on reducing problem behaviors among youth. In ITT analyses, youth were analyzed according to their original study community's randomized condition even if they moved away from the community over the course of follow-up and received little to no exposure to intervention activities. Using inverse probability weights (IPWs), this study estimated effects of CTC in the same randomized trial among youth who remained in their original study communities throughout follow-up...
June 2018: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/29432783/effect-of-target-temperature-management-at-32-34-%C3%A2-c-in-cardiac-arrest-patients-considering-assessment-by-regional-cerebral-oxygen-saturation-a-multicenter-retrospective-cohort-study
#14
Yuka Nakatani, Takeo Nakayama, Kei Nishiyama, Yoshimitsu Takahashi
AIM: Target temperature management (TTM) is used in comatose post-cardiac arrest patients, but the recommended temperature range is wide. This study aimed to assess the effectiveness of TTM at 32-34 °C while considering the degree of cerebral injury and cerebral circulation, as assessed by regional cerebral oxygen saturation (rSO2 ). METHODS: This is a secondary analysis of prospectively collected registry data from comatose patients who were transferred to 15 hospitals in Japan after out-of-hospital cardiac arrest (OHCA) from 2011 to 2013...
May 2018: Resuscitation
https://www.readbyqxmd.com/read/29424486/association-between-dental-visiting-and-missing-teeth-estimation-using-propensity-score-adjustment
#15
Meghashyam Bhat, Loc G Do, Kaye Roberts-Thomson
AIM: The aim of the present study was to determine the association between dental visiting and missing teeth using propensity score (PS) adjustment to control for confounding bias, and to compare the estimates with those obtained from traditional regression models. METHODS: A population-based study was conducted on adults aged 35-54 years in India. Multistage stratified cluster random sampling was used. Data were collected through interviews and oral examinations...
February 9, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29411117/computer-tomography-based-morphometric-analysis-of-the-cervical-spine-pedicles-c3-c7
#16
Leonard Westermann, Carolin Spemes, Peer Eysel, Marvin Simons, Max J Scheyerer, Jan Siewe, Dominik Baschera
BACKGROUND: Our aim was to examine the specific dimensions of cervical pedicles in a large Caucasian cohort on high dissolving CT scans. METHODS: A retrospective analysis of 100 cervical spine CT scans with a maximum slice thickness of 1 mm in axial, sagittal, and coronal reconstructions was performed. The pedicle axial length (PAL), inner and outer pedicle diameter (IPD/OPD), pedicle sagittal and transverse angle (PSA/PTA), pedicle height (PH), pedicle width (PW), and the cortical thickness (COT) at different margins were measured by two independent observers...
April 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29408612/shorter-duration-of-antibiotic-treatment-for-acute-bacteraemic-cholangitis-with-successful-biliary-drainage-a-retrospective-cohort-study
#17
A Doi, T Morimoto, K Iwata
OBJECTIVES: To assess the effectiveness of short duration antimicrobial therapy for acute cholangitis with bacteraemia. METHODS: We conducted a retrospective cohort study of patients with acute bacteraemic cholangitis with successful biliary duct drainage at a single centre in Japan. We compared short-course antimicrobial therapy (SCT, ≤7 days) and long-course therapy (LCT, ≥8 days), with a primary outcome of 30-day mortality. We constructed logistic regression models for mortality and a composite outcome, including mortality, recurrence, recrudescence, new bacteraemia, liver abscess or other complications related to cholangitis...
March 7, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29401225/reducing-the-period-of-data-collection-for-intake-and-gain-to-improve-response-to-selection-for-feed-efficiency-in-beef-cattle
#18
Richard Mark Thallman, Larry A Kuehn, Warren M Snelling, Kelli J Retallick, Jennifer M Bormann, Harvey C Freetly, Kristen E Hales, Gary L Bennett, Robert L Weaber, Daniel W Moser, Michael D MacNeil
Shortening the period of recording individual feed intake may improve selection response for feed efficiency by increasing the number of cattle that can be recorded given facilities of fixed capacity. Individual DMI and ADG records of 3,462 steers and 2,869 heifers over the entire intake recording period (range 62 to 154 d; mean 83 d; DMI83 and ADG83, respectively), DMI and ADG for the first 42 d of the recording period (DMI42 and ADG42, respectively), and postweaning ADG based on the difference between weaning and yearling weights (PADG) were analyzed...
April 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29380478/a-comparison-of-care-delivered-in-hospital-based-and-freestanding-emergency-departments
#19
Jesse M Pines, Mark S Zocchi, Bernard S Black
OBJECTIVE: We compare case mix, hospitalization rates, length of stay (LOS), and resource use in independent freestanding emergency departments (FSEDs) and hospital-based emergency departments (H-EDs). METHODS: Data from 74 FSEDs (2013-2015) in Texas and Colorado were compared to H-ED data from the 2013-2014 National Hospital Ambulatory Medical Care Survey. In the unrestricted sample, large differences in visit characteristics (e.g., payer and case mix) were found between patients that use FSEDs compared to H-EDs...
January 30, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29302611/the-health-benefits-of-secondary-education-in-adolescents-and-young-adults-an-international-analysis-in-186-low-middle-and-high-income-countries-from-1990-to-2013
#20
Russell M Viner, Dougal S Hargreaves, Joseph Ward, Chris Bonell, Ali H Mokdad, George Patton
Background: The health benefits of secondary education have been little studied. We undertook country-level longitudinal analyses of the impact of lengthening secondary education on health outcomes amongst 15-24 year olds. Methods: Exposures: average length of secondary and primary education from 1980 to 2013.Data/Outcomes: Country level adolescent fertility rate (AFR), HIV prevalence and mortality rate from 1989/90 to 2013 across 186 low-, middle- and high-income countries...
December 2017: SSM—Population Health
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