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https://www.readbyqxmd.com/read/28722173/the-development-of-non-essentialist-concepts-of-ethnicity-among-children-in-a-multicultural-london-community
#1
Ruth Woods
Ethnic constancy, the belief that a person cannot change ethnicity, is an important component of ethnic essentialism, the conviction that members of ethnic groups share an immutable underlying essence. Most children in previous research viewed ethnicity as increasingly immutable with age. However, some evidence suggests that children growing up in communities, which define ethnicity primarily in terms of changeable features (e.g., lifestyle) rather than fixed features (e.g., ancestry), may not follow this trajectory...
July 19, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28721008/effect-of-age-sex-and-refractive-errors-on-central-corneal-thickness-measured-by-oculus-pentacam-%C3%A2
#2
Nauman Hashmani, Sharif Hashmani, Azfar N Hanfi, Misbah Ayub, Choudhry M Saad, Hina Rajani, Marium G Muhammad, Misbahul Aziz
BACKGROUND: Central corneal thickness (CCT) can be used to assess the corneal physiological condition as well as the pathological changes associated with ocular diseases. It has an influence on the measurement of intraocular pressure and is being used as a screening tool for refractive surgery candidates. The aim of this study was to determine the median CCT among normal Pakistani population and to correlate CCT with age, sex, and refractive errors. METHODS: We conducted a retrospective analysis of 5,171 healthy eyes in 2,598 patients who came to Hashmanis Hospital, Karachi, Pakistan...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28718258/variations-in-the-age-of-fusion-of-ischial-tuberosity-a-radiological-study
#3
Hina Siddiqi, Sarah Nisar, Nazish Waheed
BACKGROUND: Human skeleton develops from separate ossification centres which continue to ossify till the bone is completely formed. Radiological techniques are very reliable and useful method for estimating the age of individual for forensic and criminal reasons by observing these ossification centres. External inspection for age determination is liable to error. This study is thus aimed to assess the variation in age of fusion of ischial tuberosity in Pakistani population. METHODS: It was a cross sectional study, wherein data was retrospectively collected at Bahawalpur Victoria Hospital, a tertiary referral centre in which consecutively selected 47 females and 121 males between 10-24 years of age, attending the outpatient, referred from National Database and Registration Authority for the confirmation of age were selected...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28718242/ectopic-pregnancy-with-tubal-rupture-an-analysis-of-80-cases
#4
Sana Ashfaq, Sadia Sultan, Safia Aziz, Marium Mohammed Irfan, Miray Hasan, Afshan Siddique
BACKGROUND: Ectopic pregnancy (EP) is a major problem in obstetrics as there is evidence of increasing incidence throughout the world. It is an important cause of maternal morbidity and mortality. In Pakistan, the care seeking behaviour among female is limited that makes female vulnerable to die due to complication of ectopic pregnancy. The aim of this study is to determine the frequency of tubal rupture in ectopic pregnancy in Pakistani patients. METHODS: In this crosssectional study data pertaining to age, gestational age, parity and duration of presenting symptoms were collected and analysed...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712187/utility-of-heart-type-fatty-acid-binding-protein-h-fabp-point-of-care-test-in-the-early-hours-of-stemi-compared-with-troponin-i-in-pakistani-population
#5
Walid Ahmad Abbasi, Muhammad Saleem, Shahid Rasheed, Azhar Mahmood Kiyani
BACKGROUND: Acute coronary syndrome remains a dominant cause of high morbidity and mortality despite advancements in treatment This study was conducted to examine the utility of point-of-care test of heart-type fatty-acid binding protein (h-FABP) and compare it with the point-of-care test of cardiac troponin I (cTnI) in the first 06 hours of STEMI. METHODS: This cross-sectional, comparative study which was conducted in Rawalpindi institute of cardiology, Rawalpindi, Pakistan, from January to June 2015...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712178/cognitive-potential-and-its-predictors-in-children-from-a-rural-district-of-pakistan
#6
Irum Gilani
BACKGROUND: Effective interventions are available to reduce cognitive deficit currently estimated to affect more than 200 million children under 5 years of age in developing countries. However, developing world's investment is negligible in this regard mainly because of non-existent global indicators to monitor progress with respect to the childhood cognitive development. Intelligence Quotient (IQ) or Full Scale Intelligence Quotient (FSIQ) is an indicator of the cognitive development...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28707069/variants-in-the-prpf8-gene-are-associated-with-glaucoma
#7
Shazia Micheal, Barend F Hogewind, Muhammad Imran Khan, Sorath Noorani Siddiqui, Saemah Nuzhat Zafar, Farah Akhtar, Raheel Qamar, Carel B Hoyng, Anneke I den Hollander
Glaucoma is the cause of irreversible blindness worldwide. Mutations in six genes have been associated with juvenile- and adult-onset familial primary open angle glaucoma (POAG) prior to this report but they explain only a small proportion of the genetic load. The aim of the study is to identify the novel genetic cause of the POAG in the families with adult-onset glaucoma. Whole exome sequencing (WES) was performed on DNA of two affected individuals, and predicted pathogenic variants were evaluated for segregation in four affected and three unaffected Dutch family members by Sanger sequencing...
July 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28705719/prevalence-of-ebv-hpv-and-mmtv-in-pakistani-breast-cancer-patients-a-possible-etiological-role-of-viruses-in-breast-cancer
#8
Wasifa Naushad, Orooj Surriya, Hajra Sadia
BACKGROUND: Breast cancer being a multifactorial disease, the role of infectious agent in development of disease is of great interest. The high incidence of breast cancer around the world has woken the interest in a viral etiology of breast cancer. Despite decades of research, no etiologic factor(s) for human breast cancer has been known and the quest for a contributing cause has all but been abandoned during the past years. Recent investigations have linked breast cancer to viral infections, such as Epstein-Barr virus (EBV), Human papillomavirus (HPV) and mouse mammary tumor virus...
July 10, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28705542/effect-of-coronary-artery-disease-risk-snps-on-serum-cytokine-levels-and-cytokine-imbalance-in-premature-coronary-artery-disease
#9
Wafa M Ansari, Steve E Humphries, Abdul K Naveed, Omer J Khan, Dilshad A Khan, Ejaz Hassan Khattak
BACKGROUND: Premature Coronary Artery Disease (PCAD) occurs almost a decade earlier in the South Asian population as compared to the West. Inclusion of genetic information can prove to be a robust measure to improve early risk prediction of PCAD. Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls...
July 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28701798/cognitive-behavioral-therapy-as-an-adjunct-treatment-for-pakistani-men-with-ed
#10
S Khan, A Amjad, D Rowland
The goal of this study was to determine potential positive effects of cognitive behavioral therapy (CBT) on Pakistani men with ED who were undergoing treatment with a PDE-5 inhibitor. We used a pre-post research design comparing men with and without adjunctive CBT. Men in the two groups were compared to determine whether CBT improved sexual function, as measured by the International Index of Erectile Function (IIEF). A total of 60 individuals diagnosed with ED completed the study. Participants were systematically assigned to one of two groups, the CBT group or the control group...
July 13, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28698971/living-with-diabetes-personal-interviews-with-pakistani-women-in-norway
#11
Walaa Abuelmagd, Helle Håkonsen, Khadijah Qurrat-Ul-Ain Mahmood, Najmeh Taghizadeh, Else-Lydia Toverud
The prevalence of Type 2 diabetes (T2D) among Pakistani women in Norway is remarkably high. This study aims to assess how they live with the disease and their response to lifestyle and medical information. 120 Pakistani women living in Norway (mean age: 55.7 years) were personally interviewed about their T2D using a structured questionnaire (response rate: 95%). The participants were first-generation immigrants (mean residence time: 28.7 years) of whom 27% were illiterates. Poor health was reported by one-third, and 71% had developed macrovascular comorbidities...
July 11, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28695172/women-experiences-of-using-external-breast-prosthesis-after-mastectomy
#12
Zohra Asif Jetha, Raisa B Gul, Sharifa Lalani
OBJECTIVE: The aim of this study was to identify the experiences of breast cancer patients using external breast prostheses (EBP) in the context of the Pakistani society. METHODS: A qualitative descriptive exploratory design was used in the study. In-depth individual interviews were conducted with 15 postmastectomy women using EBP. A semi-structured interview guide with open-ended questions was used for the interviews. The analysis of the data was organized into four categories according to the study questions including reasons for using EBP, feeling about EBP, challenges for using EBP, and coping with lost breast...
July 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28693477/clinical-consequences-of-untreated-dental-caries-assessed-using-pufa-index-and-its-covariates-in-children-residing-in-orphanages-of-pakistan
#13
Ramsha Kamran, Warda Farooq, Mehreen Riaz Faisal, Faisal Jahangir
BACKGROUND: The purpose of this study was to determine the prevalence and clinical effects of untreated dental caries in Pakistani children residing in orphanages using the DMFT and PUFA index; association of decay and untreated dental caries with demographics including type of orphanage; behavioural and dental visiting pattern; and association of dental pain experience and type of orphanage with dental visiting. METHODS: A cross-sectional survey was conducted on a total of 753 orphan children belonging to 4-17 years of age group residing in twin cities of Rawalpindi and Islamabad, Pakistan...
July 11, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28690950/the-role-of-parents-literacy-in-malnutrition-of-children-under-the-age-of-five-years-in-a-semi-urban-community-of-pakistan-a-case-control-study
#14
Umme K Khattak, Saima P Iqbal, Haider Ghazanfar
OBJECTIVES: According to a recent survey, Pakistan was ranked as the third highest country with malnutrition and the under-five child mortality. No realistic solution for this growing problem has been found despite the fact that the struggle to tackle the issue of malnutrition among young Pakistani children has been going on for the last several decades. The objective of our study was to look into the relationship between parental education and malnutrition in Pakistan and to make a recommendation to improve the nutritional condition of the children...
June 5, 2017: Curēus
https://www.readbyqxmd.com/read/28689526/tension-free-vaginal-taping-in-pakistani-women-with-stress-urinary-incontinence
#15
Ayesha Saleem
OBJECTIVE: To evaluate the effectiveness and determine the peroperative and postoperative complications of tension-free vaginal tape (TVT) sling for urinary stress incontinence (USI) and contributing factors to complications. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Kidney Centre Postgraduate Institute, Karachi, from January 2009 to December 2010. METHODOLOGY: One hundred consecutive patients underwent TVT as per Ulmsten Technique for urinary stress incontinence and patients were followed for 3 years...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28689522/efficacy-and-toxicity-of-concurrent-chemoradiation-in-inoperable-oral-carcinoma-in-pakistani-population
#16
Abdul Rehman, Zafar Allaudin, Hasan Nisar, Irfan Ullah Khan, Ismat Fatima, Amira Shami, Misbah Masood, Abubaker Shahid
OBJECTIVE: To evaluate the efficacy of concurrent chemoradiation in patients with locally advanced inoperable squamous cell carcinoma of oral cavity in terms of local control and toxicity. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from January 2008 to December 2013. METHODOLOGY: Sixty-nine patients with locally advanced inoperable oral cavity cancer, registered in INMOL hospital from January 2008 to December 2013 who fulfilled a pre-defined eligibility criteria, were enrolled in the study...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28685811/homozygosity-for-a-missense-variant-in-comp-gene-associated-with-severe-pseudoachondroplasia
#17
Muhammad Tariq, Tahir Naeem Khan, Lars Lundin, Muhammad Jameel, Torsten Lönnerholm, Shahid Mahmood Baig, Niklas Dahl, Joakim Klar
The phenotypic spectrum associated with heterozygous mutations in cartilage oligomeric matrix protein gene (COMP) range from a mild form of multiple epiphyseal dysplasia (MED) to pseudoachondroplasia (PSACH). However, the phenotypic effect from biallelic COMP variants is unclear. We investigated a large consanguineous Pakistani family with a severe form of PSACH in two individuals. Another 14 family members presented with a mild PSACH phenotype similar to MED. Using exome sequencing and subsequent segregation analysis, we identified homozygosity for a COMP missense variant (c...
July 7, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28683801/prevalence-trajectories-and-determinants-of-television-viewing-time-in-an-ethnically-diverse-sample-of-young-children-from-the-uk
#18
Sally E Barber, Brian Kelly, Paul J Collings, Liana Nagy, Tracey Bywater, John Wright
BACKGROUND: Excessive screen viewing in early childhood is associated with poor physical and psycho-social health and poor cognitive development. This study aimed to understand the prevalence, trajectory and determinants of television viewing time in early childhood to inform intervention development. METHODS: In this prospective longitudinal study, mothers of 1558 children (589 white British, 757 Pakistani heritage, 212 other ethnicities) completed questionnaires when their children were approximately 6, 12, 18, 24 and 36 months old...
July 6, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28680508/further-evidence-for-the-association-of-cyp2d6-4-gene-polymorphism-with-parkinson-s-disease-a-case-control-study
#19
Anwarullah, Muhammad Aslam, Mazhar Badshah, Rashda Abbasi, Aneesa Sultan, Kafaitullah Khan, Nafees Ahmad, Jakob von Engelhardt
BACKGROUND: Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently in a reduction in metabolism of some toxins...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28679403/identification-and-in-silico-characterization-of-p-g380r-substitution-in-fgfr3-associated-with-achondroplasia-in-a-non-consanguineous-pakistani-family
#20
Muhammad Ajmal, Asif Mir, Muhammad Shoaib, Salman Akbar Malik, Muhammad Nasir
BACKGROUND: The dimerization efficiency of FGFR3 transmembrane domain plays a critical role in the formation of a normal skeleton through the negative regulation of bone development. Recently, gain-of-function mutations in the transmembrane domain of FGFR3 has been described associated with an aberrant negative regulation, leading to the development of achondroplasia-group disorders, including achondroplasia (ACH), hypochondroplasia (HCH) and thanatophoric dysplasia (TD). Here, we describe a non-consanguineous Pakistani family with achondroplasia to explain hereditary basis of the disease...
July 5, 2017: Diagnostic Pathology
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