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https://www.readbyqxmd.com/read/27908797/molecular-detection-and-characterization-of-respiratory-syncytial-virus-b-genotypes-circulating-in-pakistani-children
#1
Uzma Bashir, Nadia Nisar, Nayab Mahmood, Muhammad Masroor Alam, Hajra Sadia, Syed Sohail Zahoor Zaidi
Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in young children, but very little is known about its epidemiology and circulating genotypes in Pakistan. This study analyzed the epidemiological and molecular characteristics of RSV B genotypes in Pakistani children below 5years with acute respiratory tract infections (ARIs) during three consecutive winter seasons from 2010 to 2013. A total of 1941 samples were analyzed for RSV infection by real time PCR and 24% (472/1941) samples were found positive out of which 22...
November 28, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27895375/clinical-profile-treatment-and-survival-outcomes-of-peadiatric-germ-cell-tumours-a-pakistani-perspective
#2
Irfan Ul Islam Nasir, Muhammad Ijaz Ashraf, Nouman Ahmed, Muhammad Fahd Shah, Muhammad Taqi Pirzada, Amir Ali Syed, Abid Quddus Qazi
Germ Cell Tumours (GCTs) are rare tumours. Generally 80% are benign and 20% malignant with a bimodal age distribution. The retrospective study was conducted at Shaukat Khanum Cancer Hospital, Lahore, Pakistan, and comprised all paediatric patients below 18 years of age who received treatment for histology-proven GCT from 2006 to 2014. Of the 207 patients, 98(42.3%) were males and 109(52.7%) were females. The most common GCT was yolk sac tumour in 90(43.5%) children followed by mixed GCT in 40(19.3%) and dysgerminoma in 34(16...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27895369/improvement-in-quality-of-lifesix-months-after-primary-total-hip-arthroplasty-in-a-pakistani-population
#3
Akbar Jaleel Zubairi, Syed Usman Bin Mahmood, Moiz Ali, Shahryar Noordin
This prospective, cohort study was carried out to assess the improvement in quality of life of patients undergoing elective primary total hip arthroplasty (THA). It was conducted at the orthopaedic department of the Aga Khan University Hospital, Karachi, from June 2014 to May 2015, and comprised patients who had undergone THA. A total of 89 patients having a mean age of 41.5±12.0 years with a baseline core outcomes measure index (COMI)-hip score of > 3.5 were included. A decrease in COMI-hip score by >3 points six months post-operatively was considered improvement in quality of life...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27895353/bacterobilia-in-acute-cholecystitis-bile-cultures-isolates-antibiotic-sensitivities-and-antibiotic-usage-a-study-on-a-pakistani-population
#4
Yousaf Bashir Hadi, Muhammad Waqas, Hafiz Muhammad Umer, Ammar Alam, Abdul Rehman Alvi, Muhammad Rizwan Khan
Acute cholecystitis is one of the most common acute surgical conditions. Laparoscopic cholecystectomy remains the mainstay of treatment. In patients managed non-operatively, antibiotics play an important role in the treatment of cholecystitis. The current retrospective observational study was conducted at a tertiary care hospital in Karachi, and comprised medical records of patients admitted between 2008 and 2014with acute cholecystitis and in whom bile cultures were obtained. Of the 509 patients with a mean age of 51...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27895350/age-estimation-of-a-sample-of-pakistani-population-using-coronal-pulp-cavity-index-in-molars-and-premolars-on-orthopantomogram
#5
Sheikh Bilal Badar, Robia Ghafoor, Farhan Raza Khan, Muhammad Hasan Hameed
The aim of the present study was to assess the validity of tooth-coronal index (TCI) in the age estimation. This retrospective charts review was conducted at the Aga Khan University Hospital, Karachi from January 2016 to March 2016, and comprised 315 teeth of 80 individuals. The teeth were analysed on Orthopantomogram. TCI was calculated for unrestored mandibular premolars and molars. Pearson\\\'s correlation was applied to assess correlation between chronological age and TCI. Besides, 30(37.5%) subjects were male and 50(62...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27892690/ethnic-differences-in-women-s-use-of-mental-health-services-do-social-networks-play-a-role-findings-from-a-national-survey
#6
Dharmi Kapadia, James Nazroo, Mark Tranmer
OBJECTIVES: The reasons for ethnic differences in women's mental health service use in England remain unclear. The aims of this study were to ascertain: ethnic differences in women's usage of mental health services, if social networks are independently associated with service use, and if the association between women's social networks and service use varies between ethnic groups. DESIGN: Logistic regression modelling of nationally representative data from the Ethnic Minority Psychiatric Illness Rates in the Community (EMPIRIC) survey conducted in England...
November 28, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27885738/a-collaborative-exploration-of-the-reasons-for-lower-satisfaction-with-services-among-bangladeshi-and-pakistani-social-care-users
#7
Margaret Blake, Alison Bowes, Valdeep Gill, Fatima Husain, Ghazala Mir
This study explored underlying reasons for the expression of dissatisfaction with services among Bangladeshi and Pakistani social care users in England and investigated, using a collaborative approach, how these could be addressed. In-depth interviews were conducted in Birmingham, Leeds and London during 2012-2013 with 63 Bangladeshi, Pakistani and white British service users and 24 social care managers, social workers and care workers. A further 34 cognitive interviews were conducted within the same study...
November 25, 2016: Health & Social Care in the Community
https://www.readbyqxmd.com/read/27882022/association-of-rs1800668-polymorphism-in-glutathione-peroxidase-1-gene-and-risk-of-rheumatoid-arthritis-in-pakistani-population
#8
Shazia Irfan, Asima Rani, Maryam Sameem, Syed Kashif Nawaz, Iram Liaqat, Muhammad Arshad
OBJECTIVE: To investigate the role of glutathione peroxidase 1 (GPX1) C/T polymorphism (rs1800668) in modulating the chances of Rheumatoid arthritis (RA) in Pakistani population. METHODS: A total of 400 individuals including 200 controls and 200 patients of RA, were genotyped. Detection of rs1800668 polymorphism was carried out using PCR based amplification strategy (allele specific). RESULTS: The results for Hardy Weinberg Equilibrium (HWE) indicated that the allele frequencies for GPX1 polymorphism were not deviant from HWE in whole population under observation...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27882002/a-simple-integrated-primary-health-care-based-model-for-detection-of-diabetic-retinopathy-in-resource-limited-settings-in-pakistani-population
#9
Ali Jawa, Muhammad Zaman Khan Assir, Syed Hunain Riaz, Rashin Chaudhary, Farooq Awan, Javed Akram
OBJECTIVE: To find out prevalence of Diabetic Retinopathy in general population of three districts in Pakistan. METHODS: A community based cross-sectional survey was conducted in three large districts of Pakistan namely Rawalpindi in Punjab, Peshawar in Khyber Pakhtoonkhwa and Hyderabad in Sindh between January 2013 and August 2015. Lady Health Workers identified individuals at high risk for diabetes based on pre-defined criteria. High risk population was tested for dysglycemia...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27879469/frequency-of-common-vkorc1-polymorphisms-and-their-impact-on-warfarin-dose-requirement-in-pakistani-population
#10
Aisha Qayyum, Muzammil Hasan Najmi, Qaisar Mansoor, Muhammad Irfan, Abdul Khaliq Naveed, Andleeb Hanif, Ali Raza Kazmi, Muhammad Ismail
Polymorphisms in vitamin K epoxide reductase complex subunit 1 (VKORC1) gene lead to interindividual variability in warfarin dose requirement. The characterization of genotype frequency distribution is required in different populations for construction of customized dosing algorithms to enhance the efficacy and reduce the toxicity of warfarin therapy. This study was carried out in Pakistani population to evaluate the contribution of common VKORC1 polymorphisms to warfarin therapy. A total of 550 stable patients taking warfarin were enrolled after medical history, physical examination, and laboratory investigations...
November 21, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27872574/prevalence-and-pattern-of-dyslipidemia-in-hyperglycemic-patients-and-its-associated-factors-among-pakistani-population
#11
Maliha Sarfraz, Sanaullah Sajid, Muhammad Aqeel Ashraf
In diabetes mellitus dyslipidemia is one of the major risk factors for cardiovascular disease. In type 2 diabetes mellitus early detection and treatment of dyslipidemia can avoid risk for cardiovascular disorder. The present study was carried to determine the prevalence and pattern of hyperlipidemia in patients with hyperglycemia. The cross sectional study was done in different laboratories of Pakistan, the laboratories served patients referred from different government and private hospitals between July 2014 and June 2015...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27860004/hot-spots-of-wheat-yield-decline-with-rising-temperatures
#12
Senthold Asseng, Davide Cammarano, Bruno Basso, Uran Chung, Phillip D Alderman, Kai Sonder, Matthew Reynolds, David B Lobell
Many of the irrigated spring wheat regions in the world are also regions with high poverty. The impacts of temperature increase on wheat yield in regions of high poverty are uncertain. A grain yield-temperature response function combined with a quantification of model uncertainty was constructed using a multimodel ensemble from two key irrigated spring wheat areas (India and Sudan) and applied to all irrigated spring wheat regions in the world. Southern Indian and southern Pakistani wheat-growing regions with large yield reductions from increasing temperatures coincided with high poverty headcounts, indicating these areas as future food security 'hot spots'...
November 10, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27856504/child-marriage-and-women-s-attitude-towards-wife-beating-in-a-nationally-representative-sample-of-currently-married-adolescent-and-young-women-in-pakistan
#13
Muazzam Nasrullah, Sana Muazzam, Faisal Khosa, Muhammad Mobarak Hussain Khan
BACKGROUND: Child marriage (before 18 years) is widely prevalent in Pakistan, and disproportionately affects young girls in rural, low income and poorly-educated households. Our study aims to determine the association of child marriage and attitude towards wife beating among currently married Pakistani women aged 15-24 after controlling for social equity indicators (education, wealth index, rural residence). METHODS: We limited the data from Pakistan Demographic and Health Survey, 2012-2013 to currently married women aged 15-24 years (n=2648)...
November 17, 2016: International Health
https://www.readbyqxmd.com/read/27849430/the-normalization-of-cannabis-use-among-bangladeshi-and-pakistani-youth-a-new-frontier-for-the-normalization-thesis
#14
Lisa Williams, Rob Ralphs, Paul Gray
BACKGROUND: The Asian population in Britain has grown, representing the second largest ethnic group; Bangladeshi, Pakistani, and Indian nationalities are prevalent (Jivraj, 2012 ; Office for National Statistics, 2013 ). Yet, we know relatively little about the nature and extent of their substance use. Jayakody et al. ( 2006 ) argue ethnic minority groups may be influenced by the norms and values of the dominant culture. Given recreational drug use has undergone a process of normalization in Britain (Aldridge et al...
November 16, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27826754/contribution-of-brca1-large-genomic-rearrangements-to-early-onset-and-familial-breast-ovarian-cancer-in-pakistan
#15
Muhammad U Rashid, Noor Muhammad, Asim Amin, Asif Loya, Ute Hamann
BACKGROUND: Germline mutations in BRCA1 and BRCA2 (BRCA1/2) account for the majority of hereditary breast and/or ovarian cancers. Pakistan has one of the highest rates of breast cancer incidence in Asia, where BRCA1/2 small-range mutations account for 17% of early-onset and familial breast/ovarian cancer patients. We report the first study from Pakistan evaluating the prevalence of BRCA1/2 large genomic rearrangements (LGRs) in breast and/or ovarian cancer patients who do not harbor small-range BRCA1/2 mutations...
November 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27821098/frequency-of-her2-neu-expression-in-colorectal-adenocarcinoma-a-study-from-developing-south-asian-country
#16
Asma Shabbir, Talat Mirza, Abdullah Bin Khalid, Muhammad Asif Qureshi, Sadaf Ahmed Asim
BACKGROUND: Human Epidermal Growth Factor (Her-2/neu) has strong therapeutic implications in certain cancers like breast and gastric cancer. Literature on its frequency in colorectal cancer is scarce. In this study, we have investigated the frequency of Her-2/neu expression in colorectal adenocarcinomas and its association with various clinicopathological variables. METHODS: A total of 95 patients who underwent colonoscopic biopsy or colectomy were studied after Institutional Ethical Approval...
November 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27818864/socs3-mrna-expression-and-polymorphisms-as-pretreatment-predictor-of-response-to-hcv-genotype-3a-ifn-based-treatment
#17
Rabia Aslam, Syed Mohsin Raza, Humeira Naeemi, Bushra Mubarak, Nadeem Afzal, Saba Khaliq
AIM: Suppressor of Cytokine Signaling 3 (SOCS3) gene belongs to SOCS family as one of the negative regulators of cytokine signaling and IFN response that function via the JAK-STAT pathway in antiviral response. SOCS3 expression and genetic polymorphism influences the pathogenesis and outcome of antiviral treatment in hepatitis C virus (HCV) infected patients. This study was designed for analysis of SOCS3 gene expression and polymorphism in Pakistani HCV patients. METHODS: This descriptive study was conducted on 250 diagnosed HCV genotype 3a infected subjects...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27818685/primary-sjogren-s-syndrome-presenting-as-acute-interstitial-pneumonitis-hamman-rich-syndrome
#18
Abidullah Khan, Mohammad Humayun, Iqbal Haider, Maimoona Ayub, Zakir Shah, Fahad Ajmal
A previously well, 45-year-old Pakistani lady was admitted to the medical unit on-call of Khyber Teaching Hospital (KTH) Peshawar with a 5-day history of fever, productive cough with copious mucoid sputum, dyspnea, and pleuritic chest pain. She also complained of dry eyes, mouth, and vagina. Her chest X-ray showed diffuse alveolar shadowing and arterial gas analysis confirmed type 1 respiratory failure. Over the next few days, she deteriorated rapidly making an urgent transfer to the medical intensive care unit (MICU) necessary, where she was mechanically ventilated...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27812055/carotid-intima-media-thickness-evaluation-by-ultrasound-comparison-amongst-healthy-diabetic-and-hypertensive-pakistani-patients
#19
Waseem Mirza, Mubashir Arain, Arif Ali, Vaqar Bari, Mirza Kazim, Kainat Fatima, Zafar Sajjad, Aziz Jiwani, Nadeem Ahmad
OBJECTIVE: To compare carotid Intima media thickness and atherosclerosis burden amongst healthy, diabetic and hypertensive Pakistani patients. METHODS: A cross-sectional study was carried out at the Department of radiology and family medicine, Aga Khan University Hospital Karachi from April 2014 to July 2015. Bilateral carotid ultrasound was done in 133 healthy adults, 65 hypertensive, 31 type-2 diabetic and 37 hypertensive with type-2 diabetes patients. Normal adults were matched for age and gender...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27812049/high-risk-of-malignant-transformation-of-oral-submucous-fibrosis-in-pakistani-females-a-potential-national-disaster
#20
Sidra Mohiuddin, Nazish Fatima, Salim Hosein, Nazish Fatima
OBJECTIVE: To determine the relationship of age, gender and other associated risk factors linked with malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma. METHODS: This cross-sectional, multi-centre study was conducted at both public and private tertiary care hospitals and clinics of Karachi, Pakistan, from 2004 to 2012, and comprised patients with oral submucous fibrosis and/or oral squamous cell carcinoma. Out of the total sample, malignant transformations of oral submucous fibrosis to oral squamous cell carcinoma were included...
November 2016: JPMA. the Journal of the Pakistan Medical Association
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