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https://www.readbyqxmd.com/read/28315472/complex-postaxial-polydactyly-types-a-and-b-with-camptodactyly-hypoplastic-third-toe-zygodactyly-and-other-digit-anomalies-caused-by-a-novel-gli3-mutation
#1
Sara Mumtaz, Esra Yildiz, Karmoon Lal, Aslıhan Tolun, Sajid Malik
Polydactyly is a phenotypically and genetically highly heterogeneous limb malformation with preaxial and postaxial subtypes and subtypes A and B. Most polydactyly entities are associated with GLI3 mutation. We report on 10 affected individuals from a large Pakistani kindred initially evaluated as a possible new condition. The phenotype is postaxial polydactyly types A and B associated with zygodactyly, postaxial webbing of toes and additional features not previously reported for isolated polydactyly such as camptodactyly, hypoplasia of third toe, and wide space between hallux and second toe...
March 14, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28303994/association-of-il-6-c-174g-rs-1800795-single-nucleotide-polymorphism-with-type-2-diabetes-mellitus-in-pakistani-population
#2
Amina Nadeem, Sadaf Mumtaz, Abdul Khaliq Naveed, Qaiser Mansoor, Muhammad Aslam, Arif Siddiqui, Muhammad Ismail
OBJECTIVE: To determine the association of interleukin-6 C-174G single nucleotide polymorphism with type 2 diabetes mellitus and metabolic parameters. METHODS: This case-control study was conducted from June 2012 to December 2013 at the Military Hospital Rawalpindi, the Centre for Research in Experimental and Applied Medicine, Army Medical College, Rawalpindi, and the Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan. Two cohorts of subjects were genotyped for the single nucleotide polymorphism...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28299905/variation-in-phenolic-profile-%C3%AE-carotene-and-flavonoid-contents-biological-activities-of-two-tagetes-species-from-pakistani-flora
#3
Muhammad Adnan Ayub, Abdullah Ijaz Hussain, Muhammad Asif Hanif, Shahzad Ali Shahid Chatha, Ghulam Mustafa Kamal, Muhammad Shahid, Omar Janneh
The objective of present study was to evaluate the variation in phenolic profile, β-carotene, flavonoid contents, antioxidant and antimicrobial properties of Tagetes eracta and Tagetes patula (T. erecta and T. patula) through different in vitro assays.,Antioxidant activity was determined through 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and inhibition of linoleic acid peroxidation assays and antibacterial and antifungal activities studied using the disc diffusion and resazurin microtiter-plate assays against bacterial and fungal strains...
March 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28295974/risk-factors-and-outcome-differences-in-hypoglycaemia-related-hospital-admissions-a-case-control-study-in-england
#4
Francesco Zaccardi, David R Webb, Melanie J Davies, Nafeesa N Dhalwani, Gemma Housley, Dominic Shaw, James W Hatton, Kamlesh Khunti
AIMS: To evaluate risk factors for hospital admissions for hypoglycaemia and compare length of hospitalisation, inpatient mortality, and hospital readmission between hypoglycaemia and non-hypoglycaemia-related admissions. MATERIALS AND METHODS: We used all admissions for hypoglycaemia in people with diabetes to English NHS hospital trusts between 2005 and 2014 (101,475 case admissions) and three random admissions per case in people with diabetes without hypoglycaemia (304,425 control admissions)...
March 14, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28294101/screening-of-intron-1-inversion-of-factor-viii-gene-in-130-patients-with-severe-haemophilia-a-from-pakistani-cohort
#5
Azhar Sattar, Shabbir Hussain, Muhammad Ikram Ullah, Saqib Mahmood, Shahida Mohsin
No abstract text is available yet for this article.
March 15, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28293154/coverage-and-predictors-of-routine-immunization-among-12-23-months-old-children-in-disaster-affected-communities-in-pakistan
#6
Shafiq Ur Rehman, Amna Rehana Siddiqui, Jamil Ahmed, Zafar Fatmi, Sayed Masoom Shah, Aisha Rahman, Mohammad Tahir Yousafzai
OBJECTIVES: We aimed this study to determine the relationship of various factors related to poor immunization in children in an earthquake affected community. MATERIALS AND METHODS: We conducted this cross-sectional study during 2007-2008 in Muzaffarabad district of Pakistani side of Kashmir. We selected 43 villages as clusters and in the second, 860 children between 12 and 24 months were selected from households through systematic sampling. Mothers of the eligible children were interviewed with a questionnaire...
January 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28292380/correlation-of-c-reactive-protein-and-cardiac-enzymes-with-angiographic-severity-of-coronary-artery-disease-in-pakistani-patients-with-acute-coronary-syndrome
#7
(no author information available yet)
OBJECTIVE: To determine the correlation of C-reactive protein (CRP) levels with the severity of coronary stenosis on angiography and the association of cardiac enzymes with the degree of stenosis in acute coronary syndrome (ACS) patients. Secondly, to compare association of angiographic severity of vascular stenosis with CRP in patients with ST segment elevation myocardial infarction (STEMI) and non-STEMI / Unstable angina (UA). STUDY DESIGN: Prospective, descriptive study...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28292362/invasive-ductal-carcinoma-correlation-of-immunophenotypic-features-with-age
#8
Fouzia Lateef, Saba Jamal, Surrayya Nasir, Zainab Jamil
OBJECTIVE: To evaluate the frequency of hormone receptors and Her2neu expression and their correlation with age in patients of carcinoma breast. STUDY DESIGN: Descriptive, cross-sectional study. PLACE AND DURATION OF STUDY: Department of Histopathology, Dr. Ziauddin Hospital, Karachi, between the period 2006 - 2013. METHODOLOGY: Estrogen receptors, progesterone receptors and Her2neu immunohistochemical staining was performed on all specimens of carcinoma breast of female patients...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28292208/herbal-medicines-for-diabetes-control-among-indian-and-pakistani-migrants-with-diabetes
#9
Tania Porqueddu
Drawing on data collected during a 16-month ethnographic investigation, this paper explores practices around Indians' and Pakistanis' use of herbal medications for diabetes control. The ethnographic study was conducted among Indian and Pakistani migrants in Edinburgh, Scotland and included extended participant observation, six group discussions and 21 semi-structured interviews. Respondents showed great resistance in adhering to medication prescriptions for diabetes control due to their various side effects, especially within the stomach...
April 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28289624/prevalence-of-gynaecomastia-in-male-pakistani-population
#10
Muhammad Ahmad
No abstract text is available yet for this article.
January 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28283489/maternal-education-empowerment-economic-status-and-child-polio-vaccination-uptake-in-pakistan-a-population-based-cross-sectional-study
#11
Muhammad Tahir Khan, Sidra Zaheer, Kashif Shafique
OBJECTIVES: To explore the association of maternal education and empowerment with childhood polio vaccination using nationally representative data of Pakistani mothers in a reproductive age group. DESIGN: Cross-sectional. SETTING: Secondary analysis of Pakistan Demographic and Health Survey (PDHS), 2012-2013 data was performed. PARTICIPANTS: Of the 13 558 mothers included in the survey sample, 6982 mothers were able to provide information regarding polio vaccinations...
March 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28281779/molecular-analysis-of-twelve-pakistani-families-with-nonsyndromic-or-syndromic-hearing-loss
#12
Rongrong Wang, Shirui Han, Amjad Khan, Xue Zhang
AIM: To investigate the causative genetic mutations in 12 Pakistani families with nonsyndromic or syndromic hearing loss. METHODS: Mutations in the most common causative gene for hearing loss, GJB2, were evaluated by Sanger sequencing. Targeted next-generation sequencing or whole-exome sequencing was used to analyze the genomic DNA samples from 11 probands with hearing loss. Sanger sequencing was performed to verify all identified variants. RESULTS: We found pathogenic, or likely to be pathogenic, mutations in all 12 families, including six known mutations in GJB2, SLC26A4, LHFPL5, and USH2A and eight novel mutations in ESPN, MYO7A, LRTOMT, PCDH15, USH2A, or EPS8L2...
March 10, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28280654/prevalence-and-perceptions-of-musculoskeletal-disorders-among-hospital-nurses-in-pakistan-a-cross-sectional-survey
#13
Farooq A Rathore, Rayan Attique, Yumna Asmaa
INTRODUCTION: Nursing is a professionally demanding job, and nurses are prone to develop musculoskeletal disorders. However, no data is available regarding its prevalence among Pakistani nurses. This study was conducted to document the pattern of work-related musculoskeletal disorders (WRMDs) in Pakistani nurses and their perceptions about contributing factors and management of WRMDs. METHODS: A questionnaire-based, cross-sectional survey was conducted in six hospitals in Lahore and Rawalpindi, which were selected using a convenient sampling technique...
January 26, 2017: Curēus
https://www.readbyqxmd.com/read/28275045/food-insecurity-and-mental-health-an-analysis-of-routine-primary-care-data-of-pregnant-women-in-the-born-in-bradford-cohort
#14
Madeleine Power, Eleonora Uphoff, Brian Kelly, Kate E Pickett
BACKGROUND: Since 2008, use of food banks has risen sharply in the UK; however, evidence on the epidemiology of UK food insecurity is sparse. The aim of this study was to describe the trajectory of common mental disorder across the pre-pregnancy, pregnancy and postnatal period for food secure compared with food insecure women. METHODS: Data from the Born in Bradford (BiB) cohort, the nested BiB1000 study and primary care records were linked based on National Health Service (NHS) numbers...
April 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28266639/molecular-outcomes-clinical-consequences-and-genetic-diagnosis-of-oculocutaneous-albinism-in-pakistani-population
#15
Mohsin Shahzad, Sairah Yousaf, Yar M Waryah, Hadia Gul, Tasleem Kausar, Nabeela Tariq, Umair Mahmood, Muhammad Ali, Muzammil A Khan, Ali M Waryah, Rehan S Shaikh, Saima Riazuddin, Zubair M Ahmed
Nonsyndromic oculocutaneous Albinism (nsOCA) is clinically characterized by the loss of pigmentation in the skin, hair, and iris. OCA is amongst the most common causes of vision impairment in children. To date, pathogenic variants in six genes have been identified in individuals with nsOCA. Here, we determined the identities, frequencies, and clinical consequences of OCA alleles in 94 previously unreported Pakistani families. Combination of Sanger and Exome sequencing revealed 38 alleles, including 22 novel variants, segregating with nsOCA phenotype in 80 families...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264263/a-new-genus-and-new-species-of-cicadettini-hemiptera-cicadidae-cicadettinae-from-pakistan
#16
Allen F Sanborn, Zubair Ahmed
Pakistan contains parts of the Indomalayan and Palaearctic ecozones. As a result, there is a diversity of habitats that has led to diversity in the cicada fauna. We reviewed the Pakistani cicada fauna (Ahmed and Sanborn 2010) but new records and new species continue to be found (Ahmed et al. 2010; 2012; 2013; 2014). This work continues to expand the knowledge of the Pakistani cicada fauna with the description of a new genus and new species of cicada provided to the second author from his contacts.
March 2, 2017: Zootaxa
https://www.readbyqxmd.com/read/28260480/living-donor-liver-transplant-follow-up-a-singlecenter-experience
#17
Syed Mudassir Laeeq, Farina M Hanif, Nasir Hassan Luck, Rajesh Kumar Mandhwani, Jawed Iqbal, Syed Haider Mehdi
OBJECTIVES: Liver transplant is a definite treatment of decompensated liver disease. Because of the shortage of livers from deceased donors, living-donor liver transplant is becoming more common. Here, we analyzed our clinical experience in the follow-up care of these patients. MATERIALS AND METHODS: Liver transplant recipients seen at the Sindh Institute of Urology and Transplantation (Karachi, Pakistan) were included in this analysis. Baseline characteristics and follow-up events were recorded...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260128/expressed-emotion-and-the-course-of-schizophrenia-in-pakistan
#18
Sarosh Sadiq, Kausar Suhail, John Gleeson, Mario Alvarez-Jimenez
PURPOSE: Aim of the study is to evaluate the predictive power of Expressed Emotion in Schizophrenia relapse in Pakistan. METHOD: A longitudinal study was conducted comprising 53 in-patients' sample diagnosed with Schizophrenia and their 101 key carers. Participants fulfilled DSM-IV-TR criteria for Schizophrenia based on Structural Clinical Interview for the DSM-IV diagnosis. Symptomatic status was measured through Brief Psychiatric Rating Scales-Expanded (BPRS-E)...
March 4, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28258500/a-prevalence-study-of-potentially-inappropriate-medications-use-in-hospitalized-pakistani-elderly
#19
Faizan Mazhar, Shahzad Akram, Saima Mahmood Malhi, Nafis Haider
BACKGROUND: Inappropriate prescribing in elderly patients is a widespread health problem. It is associated with increased drug-related problems and health expenditure. AIMS: To determine the prevalence and types of potentially inappropriate medications (PIM) prescribed to elderly patients with polypharmacy and the factors associated with their use in these patients. METHODS: A cross-sectional study conducted among 228 elderly hospitalized patients with polypharmacy...
March 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28255262/new-early-cenozoic-ghost-shrimps-decapoda-axiidea-callianassidae-from-pakistan-and-their-palaeobiogeographic-implications
#20
Matúš Hyžný, Sylvain Charbonnier, Didier Merle, Rafique Ahmed Lashari, Annachiara Bartolini, Grégoire Mètais
A new set of Paleocene and Eocene decapod crustaceans is described from the Kirthar Range of Pakistan. Two new ghost shrimps (Crustacea, Decapoda, Callianassidae) are described: Neocallichirus khadroensis Hyžný & Charbonnier, n. sp. from the Paleocene (Danian, Khadro Formation) of Gawar Band, Ranikot District, and Neocallichirus lakhraensis Hyžný & Charbonnier, n. sp. from the Early Eocene (Ypresian, Lakhra Formation) of Rbod Nala, Jhirak District. Both new species exhibit chelipeds which are morphologically surprisingly close to extant Neocallichirus karumba (Poore & Griffin, 1979) from the Indo-West Pacific...
September 2016: Geodiversitas
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