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https://www.readbyqxmd.com/read/29353732/cunninghamella-blakesleeana-mediated-biotransformation-of-a-contraceptive-drug-desogestrel-and-anti-mdr-staphylococcus-aureus-activity-of-its-metabolites
#1
Atia-Tul-Wahab, Mahwish Siddiqui, Iman Ibrahim, Arifa Hussain, El Hassan Ajandouz, Akram Hijazi, Elias Baydoun, M Iqbal Choudhary
Staphylococcus aureus is one of the most infectious agents among staphylococcal bacteria. Currently many strains of S. aureus have developed resistance against available antibiotics. Therefore, the treatment of infections caused by them is a major challenge. During current study, desogestrel (1), a contraceptive drug, was found to be a potent growth inhibitor of drug resistant strains of S. aureus. Therefore, in search of new and effective agents against multi-drug resistant S. aureus strains, whole-cell bio-catalytic conversion of desogestrel (1) by Cunninghamella blakesleeana ATCC 8688A at pH 7...
January 2, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29351305/gender-stereotypes-and-education-a-comparative-content-analysis-of-malaysian-indonesian-pakistani-and-bangladeshi-school-textbooks
#2
Kazi Md Mukitul Islam, M Niaz Asadullah
Using government secondary school English language textbooks from Malaysia, Indonesia, Pakistan and Bangladesh, we conducted a quantitative content analysis in order to identify gender stereotypes in school education. In total, 21 categories of exclusion and quality of representation were used to study gender stereotypes. Our analysis confirms a pro-male bias in textbooks: the aggregate female share is 40.4% in textual and pictorial indicators combined. Female occupations are mostly traditional and less prestigious while the characters are predominantly introverted and passive in terms of personality traits...
2018: PloS One
https://www.readbyqxmd.com/read/29348084/molecular-characterization-of-autosomal-recessive-non-syndromic-hearing-loss-in-selected-families-from-district-mardan-pakistan
#3
Shahid Hussain, Jabar Zaman Khattak, Mohammad Ismail, Qaisar Mansoor, Mohammad Haroon Khan
Deafness is the most common sensory disorder, which affects 1/1000 neonates globally. Genetic factors are major contributors for hearing impairment. This study was conducted to explore the linkage of DFNB loci and their mutations with NSHL in selected Pakistani families. We included 10 families with history of deafness from district Mardan, Pakistan. Blood sample (5ml) along with personal and clinical information was collected from the available family members including both diseased and un-affected individuals...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29340806/distribution-of-il28b-and-il10-polymorphisms-as-genetic-predictors-of-treatment-response-in-pakistani-hcv-genotype-3-patients
#4
Humaira Naeemi, Rabia Aslam, Syed Mohsin Raza, Muhammad Aiman Shahzad, Shagufta Naz, Sobia Manzoor, Saba Khaliq
There are over 10 million hepatitis C virus (HCV)-infected patients in Pakistan. For these patients, a combination of interferon with ribavirin is the most economical and easily available treatment. Single-nucleotide polymorphisms in interleukin genes have been reported to be associated with the pathogenesis and clearance of HCV, and sustained virologic response (SVR). An interleukin 28B (IL28B) gene polymorphism has been shown to modify treatment outcomes, but the effects of interleukin 10 (IL10) polymorphisms have not been previously assessed in the Pakistani population...
January 16, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29330974/nucleic-acid-amplification-test-for-detection-of-west-nile-virus-infection-in-pakistani-blood-donors
#5
Saifullah Khan Niazi, Maqbool Alam, Muhammad Sajid Yazdani, Eijaz Ghani, Muhammad Ali Rathore
BACKGROUND: The study was planned to determine the presence of West Nile Virus (WNV) infection in Pakistani blood donors, using Nucleic Acid Amplification Test (NAT). METHODS: The blood donors for study were selected on the basis of the standard questionnaire and routine screening results. Six donors were pooled using an automated pipettor and NAT for WNV was performed on Roche Cobas s 201 NAT system. The reactive pools were resolved in Individual Donation-NAT (ID-NAT) format and a sample from FFP bags of reactive donations was retrieved...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29329585/involvement-of-hedgehog-pathway-in-early-onset-aggressive-molecular-subtypes-and-metastatic-potential-of-breast-cancer
#6
Syeda Kiran Riaz, Jahangir Sarwar Khan, Syed Tahir Abbas Shah, Fen Wang, Lin Ye, Wen G Jiang, Muhammad Faraz Arshad Malik
BACKGROUND: Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are explored in the study. METHOD: One hundred fifty fresh tumours of breast cancer patients were collected for the study. Based on differential expression, panel of 6 key regulators of the pathway (SHH, DHH, IHH, PTCH1, SMO and GLI1) in microarray datasets were identified...
January 8, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29322508/a-novel-homozygous-variant-in-bmpr1b-underlies-acromesomelic-dysplasia-hunter-thompson-type
#7
Asmat Ullah, Muhammad Umair, Dost Muhammad, Muhammad Bilal, Kwanghyuk Lee, Suzanne M Leal, Wasim Ahmad
Acromesomelic dysplasia is genetically heterogeneous group of skeletal disorders characterized by short stature and acromelia and mesomelia of limbs. Acromesomelic dysplasia segregates in an autosomal recessive pattern and is caused by biallelic sequence variants in three genes (NPR2, GDF5, and BMPR1B). A consanguineous family of Pakistani origin segregating a subtype of acromesomelic dysplasia called Hunter-Thompson was clinically and genetically evaluated. Genotyping of microsatellite markers and linkage analysis revealed a 7...
January 10, 2018: Annals of Human Genetics
https://www.readbyqxmd.com/read/29321360/ellis-van-creveld-syndrome-and-profound-deafness-resulted-by-sequence-variants-in-the-evc-evc2-and-tmc1-genes
#8
Muhammad Umair, Heide Seidel, Ishtiaq Ahmed, Asmat Ullah, Tobias B Haack, Bader Alhaddad, Abid Jan, Afzal Rafique, Tim M Strom, Farooq Ahmad, Thomas Meitinger, Wasim Ahmad
Ellis-van Creveld syndrome is an autosomal recessive skeletal dysplasia primarily characterized by the features such as disproportionate dwarfism, short ribs, short limbs, dysplastic nails, cardiovascular malformations, post-axial polydactyly (PAP) (bilateral) of hands and feet. EVC/EVC2 located in head-to-head arrangement on chromosome 4p16 are the causative genes for EvC syndrome. In the study, we present two families, A and B, with Pakistani and Republic of Kosovo origin, respectively. They showed features of EvC syndrome and were clinically and genetically characterized...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29311637/loss-of-function-mutations-in-adcy3-cause-monogenic-severe-obesity
#9
Sadia Saeed, Amélie Bonnefond, Filippo Tamanini, Muhammad Usman Mirza, Jaida Manzoor, Qasim M Janjua, Sadia M Din, Julien Gaitan, Alexandra Milochau, Emmanuelle Durand, Emmanuel Vaillant, Attiya Haseeb, Franck De Graeve, Iandry Rabearivelo, Olivier Sand, Gurvan Queniat, Raphaël Boutry, Dina A Schott, Hina Ayesha, Muhammad Ali, Waqas I Khan, Taeed A Butt, Tuula Rinne, Connie Stumpel, Amar Abderrahmani, Jochen Lang, Muhammad Arslan, Philippe Froguel
Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin-melanocortin pathway in controlling energy balance, appetite and body weight 1 . The majority of loss-of-function mutations (mostly recessive or co-dominant) have been identified in genes that are directly involved in leptin-melanocortin signaling. These genes, however, only explain obesity in <5% of cases, predominantly from outbred populations 2 . We previously showed that, in a consanguineous population in Pakistan, recessive mutations in known obesity-related genes explain ~30% of cases with severe obesity3-5...
January 8, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29307071/dietary-exposure-to-hch-and-ddt-congeners-and-their-associated-cancer-risk-based-on-pakistani-food-consumption
#10
Muhammad Aamir, Sardar Khan, Gang Li
Dietary exposure to organochlorine pesticides such as hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) congeners was assessed using diet study approach, and for this purpose, different food items were collected in August 2014. The levels of ∑(HCHs + DDTs) in different food groups were ranged from 2.57 to 206 ng g-1, ww, with contamination order of fish > poultry > milk > vegetables > cereals > flour > fruits. In the present study, the ratios of β-HCH/∑HCH (0.19-0...
January 6, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29304826/the-snp-rs10911021-is-associated-with-oxidative-stress-in-coronary-heart-disease-patients-from-pakistan
#11
Saleem Ullah Shahid, Shabana, Steve Humphries
BACKGROUND: rs10911021 (a single nucleotide polymorphism present upstream of the GLUL gene) affects glutamic acid metabolism, and was shown to be associated with coronary heart disease (CHD) in patients with T2DM but a definite mechanism is unknown. It may affect glutathione cycle, an important effector in the antioxidant defense mechanism, in the cells. We checked the association of this SNP with CHD and oxidative stress biomarkers, malondialdeheyde (MDA), GSH and GSSG in Pakistani patients...
January 5, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29296550/comparison-of-transepithelial-corneal-crosslinking-with-epithelium-off-crosslinking-epithelium-off-cxl-in-adult-pakistani-population-with-progressive-keratoconus
#12
Bushra Akbar, Rana Intisar-Ul-Haq, Mazhar Ishaq, Ayesha Fawad, Sabahat Arzoo, Kashif Siddique
PURPOSE: The purpose of this study is to compare the safety and efficacy of transepithelial corneal crosslinking (CXL) with epithelium-off crosslinking (epithelium-off CXL) in the treatment of progressive keratoconus in adult Pakistani population. MATERIALS AND METHODS: Sixty-four eyes of 64 consecutive patients of progressive keratoconus were included in this quasi-experimental study. Thirty-two eyes received transepithelial CXL with Peschke TE (0.25% riboflavin (Vitamin B2), 1...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29290189/relationship-among-hypovitaminosis-d-maternal-periodontal-disease-and-low-birth-weight
#13
Farhan Raza Khan, Tashfeen Ahmad, Rabia Hussain, Zulfiqar Ahmed Bhutta
OBJECTIVE: To determine if low birth weight is associated with hypovitaminosis D and periodontal disease among a sample of Pakistani women residing in district Jhelum, Punjab. STUDY DESIGN: Cross-sectional study nested in a large community-based longitudinal study. PLACE AND DURATION OF STUDY: Tehsil Pind Dadan Khan, District Jhelum, Pakistan from August 2012 to October 2015. METHODOLOGY: Women during 12-16th week of pregnancy were selected...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29284217/qualitative-case-study-of-strength-weakness-opportunity-and-threat-analysis-of-integrating-world-health-organization-patient-safety-curriculum-in-undergraduate-medical-education-in-pakistan
#14
Samreen Misbah, Usman Mahboob
Purpose: The purpose of this study was to explore the strengths, weaknesses, opportunities, and threats of integrating the World Health Organization (WHO) patient safety curriculum in medical education in Pakistan. Methods: A qualitative interpretive case study was done at Riphah International University, Islamabad, from October 2016 to June 2017. The study included nine faculty members and one expert on patient safety. The interviews were audio-taped, and a thematic analysis of transcript was done using NVivo software...
December 28, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/29282707/a-novel-mutation-in-the-hpgd-gene-causing-primary-hypertrophic-osteoarthropathy-with-digital-clubbing-in-a-pakistani-family
#15
Anwar Kamal Khan, Noor Muhammad, Sher Alam Khan, Waheed Ullah, Abdul Nasir, Sibtain Afzal, Khushnooda Ramzan, Sulman Basit, Saadullah Khan
Primary hypertrophic osteoarthropathy (PHO) is a congenital multisystemic entity characterized by three major clinical symptoms: pachydermia, periostosis, and digital clubbing. Recently it has been reported that pathogenic mutations in two genes are known to be associated with PHO: HPGD and SLCO2A1. In the present study, a five-generation consanguineous Pakistani family harboring primary hypertrophic osteoarthropathy in autosomal-recessive pattern was ascertained. Whole genome single nucleotide polymorphisms (SNPs) genotyping and sequence analysis revealed a novel homozygous missense mutation (c...
December 28, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/29280402/computer-users-ergonomics-and-quality-of-life%C3%A2-%C3%A2-evidence-from-a-developing-country
#16
Ishfaq Ahmed, Muhammad Zeeshan Shaukat
This study is aimed at investigating the quality of workplace ergonomics at various Pakistani organizations and quality of life of computer users working in these organizations. Two hundred and thirty-five computer users (only those employees who have to do most of their job tasks on computer or laptop, and at their office) responded by filling the questionnaire covering questions on workplace ergonomics and quality of life. Findings of the study revealed the ergonomics at those organizations was poor and unfavourable...
December 27, 2017: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29278784/elucidating-the-biogeographical-variation-of-the-venom-of-naja-naja-spectacled-cobra-from-pakistan-through-a-venom-decomplexing-proteomic-study
#17
Kin Ying Wong, Choo Hock Tan, Kae Yi Tan, Quraishi H Naeem, Nget Hong Tan
Naja naja is a medically important species that is distributed widely in South Asia. Its venom lethality and neutralization profile have been reported to vary markedly, but the understanding of this phenomenon has been limited without a comprehensive venom profile for the Pakistani N. naja. This study set to investigate the venom proteome of Pakistani N. naja applying reverse-phase HPLC, SDS-PAGE, mass spectrometry and data-mining approaches. The venom enzymatics and antigen binding activities were also studied...
December 23, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29275342/prevalence-and-possible-factors-associated-with-anaemia-and-vitamin-b-12-and-folate-deficiencies-in-women-of-reproductive-age-in-pakistan-analysis-of-national-level-secondary-survey-data
#18
Sajid Soofi, Gul Nawaz Khan, Kamran Sadiq, Shabina Ariff, Atif Habib, Sumra Kureishy, Imtiaz Hussain, Muhammad Umer, Zamir Suhag, Arjumand Rizvi, Zulfiqar Bhutta
OBJECTIVE: To determine the prevalence and possible factors associated with anaemia, and vitamin B12 and folate deficiencies in women of reproductive age (WRA) in Pakistan. METHODS: A secondary analysis was conducted on data collected through the large-scale National Nutrition Survey in Pakistan in 2011. Anaemia was defined as haemoglobin levels <12 g/dL, vitamin B12 deficiency as serum vitamin B12 levels of <203 pg/mL (150 pmol/L) and folate deficiency as serum folate levels <4 ng/mL (10 nmol/L)...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29258616/exploring-diet-exercise-chronic-illnesses-occupational-stressors-and-mental-well-being-of-healthcare-professionals-in-punjab-pakistan
#19
Waqas Ahmad, Ahmed Waqas, Haider Ali Saleem, Sadiq Naveed
OBJECTIVE: This data set was compiled to assess mental well-being, dietary pattern and physical health parameters of health care professionals in Pakistan. DATA DESCRIPTION: The Warwick-Edinburgh mental well-being scale was first evaluated for the Pakistani population then used, along with other measures like body mass index, exercise and dietary habits to assess health and wellbeing of health care providers. The importance of the data lies in the fact that no previous records or data exists in our knowledge that used a subjective index to assess wellbeing in Pakistani population...
December 19, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29248705/a-linear-regression-approach-to-evaluate-the-green-supply-chain-management-impact-on-industrial-organizational-performance
#20
Ubaidullah Mumtaz, Yousaf Ali, Antonella Petrillo
The increase in the environmental pollution is one of the most important topic in today's world. In this context, the industrial activities can pose a significant threat to the environment. To manage problems associate to industrial activities several methods, techniques and approaches have been developed. Green supply chain management (GSCM) is considered one of the most important "environmental management approach". In developing countries such as Pakistan the implementation of GSCM practices is still in its initial stages...
December 14, 2017: Science of the Total Environment
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