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https://www.readbyqxmd.com/read/29237497/hyaluronic-acid-is-associated-with-organ-dysfunction-in-acute-respiratory-distress-syndrome
#1
Anthony J Esposito, Pavan K Bhatraju, Renee D Stapleton, Mark M Wurfel, Carmen Mikacenic
BACKGROUND: Hyaluronic acid (HA), an extracellular matrix component, is degraded in response to local tissue injury or stress. In various animal models of lung injury, HA has been shown to play a mechanistic role in modulating inflammation and injury. While HA is present in the lungs of patients with acute respiratory distress syndrome (ARDS), its relationship to patient outcomes is unknown. METHODS: We studied 86 patients with ARDS previously enrolled in the Phase II Randomized Trial of Fish Oil in Patients with Acute Lung Injury (NCT00351533) at five North American medical centers...
December 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29235360/halo-109-301-a-phase-iii-trial-of-pegph20-with-gemcitabine-and-nab-paclitaxel-in-hyaluronic-acid-high-stage-iv-pancreatic-cancer
#2
Gary J Doherty, Margaret Tempero, Pippa G Corrie
The outlook for patients with advanced pancreatic cancer remains poor, despite significant advances in our understanding of pancreatic tumor biology. One emerging theme highlights the distinct composition of the pancreatic tumor microenvironment. Hyaluronic acid is a hydrophilic glycosaminoglycan whose production within the tumor leads to increased interstitial tumor pressure, thereby limiting the access of potentially effective circulating anticancer drugs via reduced tumor perfusion. PEGylated rHuPH20 is a multiply PEGylated recombinant human hyaluronidase that has shown promising efficacy in preclinical models and early phase clinical trials in pancreatic cancer patients...
October 23, 2017: Future Oncology
https://www.readbyqxmd.com/read/29235217/heterologous-protein-expression-in-pichia-pastoris-latest-research-progress-and-applications
#3
REVIEW
Veeresh Juturu, Jin Chuan Wu
Pichia pastoris is a well-known platform strain for heterologous protein expression. Over the past five years, different strategies to improve the efficiency of recombinant protein expression by this yeast strain have been developed; these include a patent-free protein expression kit, construction of the P. pastoris CBS7435Ku70 platform strain with its high efficiency in site-specific recombination of plasmid DNA into the genomic DNA, the design of synthetic promoters and their variants by combining different core promoters with multiple putative transcription factors, the generation of mutant GAP promoter variants with various promoter strengths, codon optimization, engineering the α-factor signal sequence by replacing the native glutamic acid at the Kex2 cleavage site with the other 19 natural amino acids and the addition of mammalian signal sequence to the yeast signal sequence, and the co-expression of single chaperones, multiple chaperones or helper proteins that aid in recombinant protein folding...
December 13, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29235181/fuzheng-huayu-capsule-as-an-adjuvant-treatment-for-hbv-related-cirrhosis-a-systematic-review-and-meta-analysis
#4
REVIEW
Tao Wang, Xuelin Zhou, Honghong Liu, Jiabo Wang, Ping Zhang, Yun Zhu, Kun Li, Shizhang Wei, Haotian Li, Lifu Wang, Ruilin Wang, Yanling Zhao
Fuzheng Huayu (FZHY) capsule, a formulated traditional Chinese medicine product with 6 Chinese herbs, is widely used for HBV-related cirrhosis as an adjuvant treatment. However, the efficacy of FZHY capsule for HBV-induced cirrhosis did not be comprehensively proved by systematic analysis. Our current analysis was aimed to assess the efficacy and safety of FZHY capsule by an evidence-based method. Databases, including China National Knowledge Infrastructure, Wangfang, VIP medicine information system, Pubmed, Embase, and Cochrane Library, were searched, and the randomized controlled trials of FZHY capsule were used for the treatment of HBV-associated liver cirrhosis...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29233714/bi-layered-nanocomposite-bandages-for-controlling-microbial-infections-and-overproduction-of-matrix-metalloproteinase-activity
#5
J Anjana, Annapoorna Mohandas, S Seethalakshmy, Maneesha K Suresh, Riju Menon, Raja Biswas, R Jayakumar
Chronic diabetic wounds is characterised by increased microbial contamination and overproduction of matrix metalloproteases that would degrade the extracellular matrix. A bi-layer bandage was developed, that promotes the inhibition of microbial infections and matrix metalloprotease (MMPs) activity. Bi-layer bandage containing benzalkonium chloride loaded gelatin nanoparticles (BZK GNPs) in chitosan-Hyaluronic acid (HA) as a bottom layer and sodium alendronate containing chitosan as top layer was developed. We hypothesized that the chitosan-gelatin top layer with sodium alendronate could inhibit the MMPs activity, whereas the chitosan-HA bottom layer with BZK GNPs (240±66nm) would enable the elimination of microbes...
December 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29232404/antioxidant-antiapoptotic-and-amino-acid-balance-regulating-activities-of-1-7-dihydroxy-3-4-8-trimethoxyxanthone-against-dimethylnitrosamine-induced-liver-fibrosis
#6
Xi-Yuan Zheng, Xin Zhao, Ying-Fan Yang, Han-Jie Jiang, Wan Li, Yi Sun, Xiao-Ping Pu
Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injury which could be caused by viral, autoimmune, drugs, and so on. Unfortunately, there was no effective therapy available for liver fibrosis in clinic. In this study, we identified the anti-fibrotic effects of 1,7-dihydroxy-3,4,8-trimethoxyxanthone (ZYC-1) on the dimethylnitrosamine (DMN)-induced rat model. ZYC-1 was isolated from Swertia punicea Hemsl and was administrated to DMN-induced rat model. ZYC decreased the hyaluronic acid (HA), type IV collagen (CIV) and hydroxyproline (Hyp) levels and inhibited the expression of α smooth muscle actin (α-SMA) and transforming growth factor beta 1 (TGF-1β)...
2017: PloS One
https://www.readbyqxmd.com/read/29232242/prediction-of-posthepatectomy-liver-failure-proposed-by-the-international-study-group-of-liver-surgery-residual-liver-function-estimation-with-99mtc-galactosyl-human-serum-albumin-scintigraphy
#7
Yoichi Mizutani, Toshinori Hirai, Shigeki Nagamachi, Atsushi Nanashima, Koichi Yano, Kazuhiro Kondo, Masahide Hiyoshi, Naoya Imamura, Tamasa Terada
PURPOSE: The International Study Group of Liver Surgery (ISGLS) proposed a definition and grading system for posthepatectomy liver failure (PHLF). We evaluated the usefulness of residual liver function estimation using Tc-galactosyl human serum albumin (Tc-GSA) for the prediction of PHLF. METHODS: Patients with liver tumors (n = 136) and scheduled for hepatectomy underwent Tc-GSA scintigraphy. Based on their imaging data, the maximal GSA removal rate (GSA-Rmax)was calculated using multicompartment analysis...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29231289/a-cell-friendly-window-for-the-interaction-of-cells-with-hyaluronic-acid-poly-l-lysine-multilayers
#8
Narayanan Madaboosi, Katja Uhlig, Stephan Schmidt, Anna S Vikulina, Helmuth Möhwald, Claus Duschl, Dmitry Volodkin
Polyelectrolyte multilayers assembled from hyaluronic acid (HA) and poly-l-lysine (PLL) are most widely studied showing excellent reservoir characteristics to host molecules of diverse nature; however, thick (HA/PLL)n films are often found cell repellent. By a systematic study of the adhesion and proliferation of various cells as a function of bilayer number "n" a correlation with the mechanical and chemical properties of films is developed. The following cell lines have been studied: mouse 3T3 and L929 fibroblasts, human foreskin primary fibroblasts VH-Fib, human embryonic kidney HEK-293, human bone cell line U-2-OS, Chinese hamster ovary CHO-K and mouse embryonic stem cells...
December 12, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29230638/application-of-the-sodium-hyaluronate-cntf-scaffolds-in-repairing-adult-rat-spinal-cord-injury-and-facilitating-neural-network-formation
#9
Yabin Xie, Wei Song, Wen Zhao, Yudan Gao, Junkui Shang, Peng Hao, Zhaoyang Yang, Hongmei Duan, Xiaoguang Li
The present study aimed to explore the potential of the sodium hyaluronate-CNTF (ciliary neurotrophic factor) scaffold in activating endogenous neurogenesis and facilitating neural network re-formation after the adult rat spinal cord injury (SCI). After completely cutting and removing a 5-mm adult rat T8 segment, a sodium hyaluronate-CNTF scaffold was implanted into the lesion area. Dil tracing and immunofluorescence staining were used to observe the proliferation, differentiation and integration of neural stem cells (NSCs) after SCI...
December 6, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29229249/enzyme-mediated-tissue-adhesive-hydrogels-for-meniscus-repair
#10
Su-Hwan Kim, Young-Hyeon An, Hwan D Kim, Kyungmin Kim, Sang-Hyuk Lee, Hyun-Gu Yim, Byung-Gee Kim, Nathaniel S Hwang
Meniscus tissues have limited regenerative capacity once damaged. The treatment options for the meniscus tissue regeneration have been limited to arthroscopic meniscectomy or surgical interventions. The injectable hydrogels based system would provide an alternative to the conventional meniscus therapy by providing a minimally invasive treatment alternative. Here we utilized enzyme-based approaches to fabricate tissue adhesive hydrogels for meniscus repair. Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking in vitro and in vivo...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29228816/ingestion-of-an-oral-hyaluronan-solution-improves-skin-hydration-wrinkle-reduction-elasticity-and-skin-roughness-results-of-a-clinical-study
#11
Imke Göllner, Werner Voss, Ulrike von Hehn, Susanne Kammerer
Intake of oral supplements with the aim of a cutaneous antiaging effect are increasingly common. Hyaluronic acid (HA) is a promising candidate, as it is the key factor for preserving tissue hydration. In our practice study, we evaluated the effect of an oral HA preparation diluted in a cascade-fermented organic whole food concentrate supplemented with biotin, vitamin C, copper, and zinc (Regulatpro Hyaluron) on skin moisture content, elasticity, skin roughness, and wrinkle depths. Twenty female subjects with healthy skin in the age group of 45 to 60 years took the product once daily for 40 days...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29226501/drop-on-drop-multimaterial-3d-bioprinting-realized-by-peroxidase-mediated-cross-linking
#12
Shinji Sakai, Kohei Ueda, Enkhtuul Gantumur, Masahito Taya, Makoto Nakamura
A cytocompatible inkjet bioprinting approach that enables the use of a variety of bioinks to produce hydrogels with a wide range of characteristics is developed. Stabilization of bioinks is caused by horseradish peroxidase (HRP)-catalyzed cross-linking consuming hydrogen peroxide (H2 O2 ). 3D cell-laden hydrogels are fabricated by the sequential dropping of a bioink containing polymer(s) cross-linkable through the enzymatic reaction and H2 O2 onto droplets of another bioink containing the polymer, HRP, and cells...
December 11, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29224214/facial-swelling-and-foreign-body-granulomatous-reaction-to-hyaluronic-acid-filler-in-the-setting-of-neratinib
#13
Brian P Hibler, Bernice Y Yan, Michael A Marchetti, Shabnam Momtahen, Klaus J Busam, Anthony M Rossi
Cosmetic injection of dermal fillers is common, with late complications increasingly recognized. Herein, we report a granulomatous reaction to hyaluronic acid filler occurring during the use of neratinib. A woman in her fifties, with metastatic adenocarcinoma of unknown primary involving the skin and bones, was referred for new-onset facial swelling. Notable past medical history included progression of disease on carboplatin/paclitaxel and a hemithyroidectomy for papillary thyroid cancer. This article is protected by copyright...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29223366/therapeutic-efficacy-and-safety-of-umbilical-cord-mesenchymal-stem-cell-transplantation-for-liver-cirrhosis-in-chinese-population-a-meta-analysis
#14
Weiwei Sang, Benji Lv, Ke Li, Yan Lu
BACKGROUND AND OBJECTIVE: Mesenchymal stem cells transfusion has been considered as a promising option for liver cirrhosis (LC). The aim of this study was to systematically evaluate the efficacy and safety of umbilical cord mesenchymal stem cells (UMSC) combined with traditional supportive therapy (TST) for the treatment of patients with LC. METHODS: Data was extracted from clinical trials published on Web of Science, PubMed, EMBASE, Cochrane Library, Wanfang and CNKI database...
December 6, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29222545/coefficient-of-friction-between-carboxymethylated-hyaluronic-acid-based-polymer-films-and-the-ocular-surface
#15
Jourdan Colter, Barbara Wirostko, Brittany Coats
Purpose: Hyaluronic acid-based polymer films are emerging as drug-delivery vehicles for local and continuous drug administration to the eye. The highly lubricating hyaluronic acid increases comfort, but displaces films from the eye, reducing drug exposure and efficacy. Previous studies have shown that careful control of the surface interaction of the film with the eye is critical for improved retention. Methods: In this study, the frictional interaction of a carboxymethylated, hyaluronic acid-based polymer (CMHA-S) with and without methylcellulose was quantified against ovine and human sclera at three axial loads (0...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29220165/photo-triggered-n2-generating-submicron-particles-for-selective-killing-of-cancer-cells
#16
Huiying Li, Wenbo Zhang, Ning He, Weijun Tong, Changyou Gao
Killing of cancer cells by applying mechanical disruption is an appealing emerging strategy for cancer treatment in recent years. In this study, photo-responsive submicron particles based on diazo-resin (DZR) which are able to release N2 under UV irradiation were prepared through a polyamine-salt aggregation method. After surface modification with hyaluronic acid (HA), the particles could be internalized selectively by cancer cells and mainly located in lysosomes after 6 h incubation. The viability of cancer cells decreased obviously after co-cultured with photo-responsive particles and UV irradiation due to the integrity damage of lysosomes by photo-triggered N2 generation and the subsequential increased reactive oxygen species...
December 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29219792/-unilateral-blindness-following-a-non-surgical-rhinoplasty-with-filler
#17
L W Schelke, M Fick, L J van Rijn, T Decates, P J Velthuis, F Niessen
BACKGROUND: A rare but known adverse event following a cosmetic filler treatment is unilateral blindness. In the Netherlands, this complication has not been reported in a patient before. CASE DESCRIPTION: A 26-year-old woman developed unilateral blindness after undergoing a cosmetic treatment of the dorsum nasi in which hyaluronic acid was used as filler. The blindness was caused by backflow of the filler via the ophthalmic artery into the carotid internal artery...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29219244/-click-on-plga-peg-and-hyaluronic-acid-gaining-access-to-anti-leishmanial-pentamidine-bioconjugates
#18
Angela Scala, Anna Piperno, Nicola Micale, Placido G Mineo, Antonio Abbadessa, Roberta Risoluti, Germano Castelli, Federica Bruno, Fabrizio Vitale, Antonio Cascio, Giovanni Grassi
Pentamidine (Pent), an antiparasitic drug used for the treatment of visceral leishmaniasis, has been modified with terminal azide groups and conjugated to two different polymer backbones (PLGA-PEG [PP] copolymer and hyaluronic acid [HA]) armed with alkyne end-groups. The conjugation has been performed by Copper Catalyzed Azido Alkyne Cycloaddition (CuAAC) using CuSO4 /sodium ascorbate as metal source. The novel PP-Pent and HA-Pent bioconjugates are proposed, respectively, as non-targeted and targeted drug delivery systems against Leishmania infections...
December 8, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29219021/review-of-the-mechanism-of-action-for-supartz-fx-in-knee-osteoarthritis
#19
Roy D Altman, Vinod Dasa, Jun Takeuchi
Objective Summarize the biologic effects of Supartz FX for knee osteoarthritis (OA), the first worldwide clinically approved intra-articular (IA) hyaluronic acid (HA) product. Design To determine the mechanism of action from preclinical and clinical studies, a literature search was conducted of Supartz FX using academic databases from 1987 to 2016. Articles on Supartz FX that deal with its mechanisms of action were extracted, categorized, and reviewed. Results Supartz FX has 2 potential mechanisms of action: (1) biomechanical: IA Supartz FX directly improves the viscoelasticity and lubrication of synovial fluid; (2) physiologic: IA Supartz FX penetrates synovium and cartilage tissues to reach HA receptors on the surface of synoviocytes and chondrocytes...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29218478/the-rejuvenating-effect-and-tolerability-of-an-auto-cross-linked-hyaluronic-acid-on-d%C3%A3-colletage-a-pilot-prospective-study
#20
Andrea Alessandrini, Kseniya Tretyakova
BACKGROUND: A novel auto-cross-linked hyaluronic acid formulation (HA-ACP) has been proposed as a treatment for skin rejuvenation. This prospective pilot study aims to assess its tolerability and performance in the treatment of skin aging of the décolletage. METHODS: Fifteen women (mean age 49.0 ± 8.0  (range 30-65)) who complained about the appearance of their décolletage were prospectively enrolled and treated with three sets of HA-ACP (IAL-SYSTEM ACP®) intradermal injections, administered three weeks apart...
December 7, 2017: Aesthetic Plastic Surgery
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