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Viscosupplementation

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https://www.readbyqxmd.com/read/28328935/intra-articular-hyaluronic-acid-in-the-management-of-knee-osteoarthritis-pharmaco-economic-study-from-the-perspective-of-the-national-health-insurance-system
#1
Thierry Thomas, Françoise Amouroux, Patrice Vincent
INTRODUCTION: Pharmaco-economic data on the management of knee osteoarthritis (OA) with intra articular hyaluronic acid (IA HA) viscosupplementation is limited. We contrasted IA HA with non-steroidal anti-inflammatory drugs (NSAIDs). METHODS: Observational, prospective and multicenter study comparing treatments of knee OA costs and efficacy with either NSAIDs alone, or hyaluronic acid (Arthrum H 2%®), during a 6-month follow-up period. The investigators were pharmacists who recorded data on disease, drug consumption and healthcare circuit...
2017: PloS One
https://www.readbyqxmd.com/read/28326422/late-hemorrhagic-pseudoseptic-arthritis-encountered-during-total-knee-arthroplasty-due-to-hyaluronic-acid-viscosupplementation
#2
Jeremy M Korsh, William Paul Bassett, Donald R Polakoff
Osteoarthritis (OA) is the most common form of arthritis and affects approximately one-third of people in the United Sates aged 65 years and older. Since 2013, the American Academy of Orthopaedic Surgeons has not been able to recommended using hyaluronic acid for patients with symptomatic OA of the knee. Subsequent publications have also cautioned against the use of viscosupplementation based on lack of efficacy and the potential for harm. We present a case of late hemorrhagic pseudoseptic arthritis encountered during TKA due to hyaluronic acid viscosupplementation...
December 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28326213/a-fatal-sepsis-caused-by-hyaluronate-knee-injection-how-much-the-medical-history-and-the-informed-consent-might-be-important
#3
F Manfreda, G Rinonapoli, A Nardi, P Antinolfi, A Caraffa
The incidence of Osteoarthritis (OA) is gradually increasing worldwide due to two main reasons: longer life expectation and increased functional demand. Several treatment options have been proposed for this disease. Conservative treatment has the goal to improve the quality of life, reduce pain, and prevent the progression of the disease. Hyaluronate viscosupplementation is one of the most used infiltrative treatments for OA, but, despite its common use, clinical efficacy is still under question. Though adverse reactions for this medical option are actually rare, septic arthritis is a very scaring complication...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28304363/knee-viscosupplementation-cost-effectiveness-analysis-between-stabilized-hyaluronic-acid-in-a-single-injection-versus-five-injections-of-standard-hyaluronic-acid
#4
Francisco J Estades-Rubio, Alvaro Reyes-Martín, Victor Morales-Marcos, Mercedes García-Piriz, Juan J García-Vera, Macarena Perán, Juan A Marchal, Elvira Montañez-Heredia
Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score greater than 7, with a homogeneous distribution of age, sex, BMI, and duration of disease, were included in this study...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28293455/viscosupplementation-of-the-knee-three-cases-of-acute-pseudoseptic-arthritis-with-painful-and-irritating-complications-and-a-literature-review
#5
Murat Aydın, Murat Arıkan, Güray Toğral, Onur Varış, Güle Aydın
Acute pseudoseptic arthritis is a very rare complication that is associated with intra-articular hyaluronic acid injections, which normally involve minimal risk. The most common adverse events that are caused by hyaluronic acid injections are inflammatory reactions or flares at the injection site. In this study, we described three cases of acute pseudoseptic arthritis that was caused by hyaluronic acid; the symptoms in these cases were reminiscent of acute septic arthritis. Moreover, we performed a literature review on pseudoseptic arthritis following hyaluronic acid injections to determine the manner in which this condition can be described, diagnosed, and treated...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28291178/comparison-of-single-intra-articular-injection-of-novel-hyaluronan-hya-joint-plus-with-synvisc-one-for-knee-osteoarthritis-a-randomized-controlled-double-blind-trial-of-efficacy-and-safety
#6
Shu-Fen Sun, Chien-Wei Hsu, Huey-Shyan Lin, I-Hsiu Liou, Yin-Han Chen, Chia-Ling Hung
BACKGROUND: Viscosupplementation has been widely used for the treatment of knee osteoarthritis. Because we found no well-controlled trial comparing single-injection regimens of hyaluronan for knee osteoarthritis, we compared the efficacy and safety of a single intra-articular injection of a novel cross-linked hyaluronan (HYA-JOINT Plus) with a single injection of Synvisc-One in patients with knee osteoarthritis. METHODS: In a prospective, randomized, controlled, double-blind trial with a 6-month follow-up, 132 patients with knee osteoarthritis (Kellgren-Lawrence grade 2 or 3) were randomized to receive 1 intra-articular injection of 3 mL of HYA-JOINT Plus (20 mg/mL) (n = 66) or 6 mL of Synvisc-One (8 mg/mL) (n = 66)...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28238583/intra-articular-knee-injections-before-total-knee-arthroplasty-outcomes-and-complication-rates
#7
Brent A Kokubun, Gregory C Manista, P Maxwell Courtney, Sean M Kearns, Brett R Levine
BACKGROUND: The relationship between intra-articular injections and complication rates after total knee arthroplasty (TKA) remains controversial. This study's purpose was to determine the relationship between the number and timing of intra-articular injections with complications and outcomes after TKA from a single surgeon's database. METHODS: We retrospectively reviewed a series of 442 patients who underwent primary TKA from 2008-2015. Patient demographics, comorbidities, number and timing of ipsilateral intra-articular injections, and preoperative and postoperative functional outcome scores were recorded...
February 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28128473/obesity-and-radiological-severity-are-associated-with-viscosupplementation-failure-in-patients-with-knee-osteoarthritis
#8
Florent Eymard, Xavier Chevalier, Thierry Conrozier
Viscosupplementation (VS) is still controversial. One of the key points is the lack of well-identified factors of response. We aimed to identify clinical and radiological factors associated with lack of relevant response after intra-articular (IA) hyaluronic acid (HA) injections in symptomatic knee osteoarthritis patients. A post hoc analysis of the HAV-2012 trial, a controlled, multicentre, double-blind, randomized, non-inferiority trial comparing 3 weekly IA injections of HA (HAnox-M or BioHA) for symptomatic tibiofemoral OA was performed...
January 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28117254/prospective-evaluation-of-intra-articular-sodium-hyaluronate-injection-in-the-ankle
#9
Evelyn P Murphy, Mark Curtin, Niall P McGoldrick, Gerard Thong, Stephen R Kearns
Viscosupplementation by injection of hyaluronic acid into the ankle can be used to provide pain relief and to delay the need for surgery in patients with osteoarthritis of the ankle. In the present investigation, we prospectively evaluated 50 consecutive patients (25 males and 25 females) undergoing a 3-injection protocol of sodium hyaluronate viscosupplementation in the ankle from January 2014 to January 2015. The Foot and Ankle Outcomes Score was used to compare the patients' pre- and post-treatment opinions about their ankle problems...
March 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28092250/-osteoarthrosis-implementation-of-current-diagnostic-and-therapeutic-algorithms
#10
Gilberto Meza-Reyes, Jorge Aldrete-Velasco, Rolando Espinosa-Morales, Fernando Torres-Roldán, Alejandro Díaz-Borjón, Manuel Robles-San Román
In the modern world, among the different clinical presentations of osteoarthritis, gonarthrosis and coxarthrosis exhibit the highest prevalence. In this paper, the characteristics of osteoarthritis and the different scales of assessment and classification of this pathology are exposed, to provide an exhibition of current evidence generated around diagnostic algorithms and treatment of osteoarthritis, with emphasis set out in the knee and hip, as these are the most frequent; a rational procedure for monitoring patients with osteoarthritis based on characteristic symptoms and the severity of the condition is also set...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28066733/viscosupplementation-with-intra-articular-hyaluronic-acid-for-hip-disorders-a-systematic-review-and-meta-analysis
#11
Eleonora Piccirilli, Francesco Oliva, Mihaela Aconstantinesei Murè, Asmaa Mahmoud, Calogero Foti, Umberto Tarantino, Nicola Maffulli
BACKGROUND: Hip joint diseases are common in adult population and their prevalence increases with age. Osteoarthritis, rheumatoid arthritis and femoroacetabular impingement are the most common chronic diseases in the hip joint. Viscosupplementation with exogenous hyaluronic acid (HA) is one of the most widely used conservative treatment aiming to improve synovial fluid properties and to decrease pain. There is no global consensus on the type of HA, method of injection and frequency, or on its efficacy in hip joint...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28056915/predictors-of-response-to-viscosupplementation-in-patients-with-hip-osteoarthritis-results-of-a-prospective-observational-multicentre-open-label-pilot-study
#12
Florent Eymard, Bernard Maillet, Henri Lellouche, Sylvie Mellac-Ducamp, Olivier Brocq, Damien Loeuille, Xavier Chevalier, Thierry Conrozier
BACKGROUND: To identify predictive factors of response to viscosupplementation (VS) in patients with hip osteoarthritis (HOA). METHODS: Prospective, multicentre, open-label trial, achieved in daily practice conditions. Patients with HOA were treated with a single intra-articular injection of a cross-linked hyaluronic acid combined with mannitol (HAnox-M-XL), using imaging guidance. WOMAC pain and function scores and patient global assessment (PGA) were assessed at baseline and day 90...
January 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28002896/comparing-hybrid-hyaluronic-acid-with-prp-in-end-career-athletes-with-degenerative-cartilage-lesions-of-the-knee
#13
R Papalia, B Zampogna, F Russo, S Vasta, M C Tirindelli, C Nobile, A C Di Martino, G Vadalà, V Denaro
Cartilage lesions are very common causes of chronic knee pain in athletes. Current treatment options consist in conservative strategies, such as viscosupplementation and platelet-rich plasma injections. This randomized controlled trial aims to investigate the effect of intra-articular Hybrid Hyaluronic Acid injections compared to PRP for the treatment of cartilage lesions among athletes at the end of their career. Since March 2015, 48 professional soccer players were randomized into two groups: 24 patients received 3 injections of HHA and 23 patients received 3 intra-articular injections of PRP...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27920810/hyaluronic-acid-in-the-management-of-osteoarthritis-injection-therapies-innovations
#14
Valter Santilli, Marco Paoloni, Massimiliano Mangone, Federica Alviti, Andrea Bernetti
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Viscosupplementation with intra-articular (IA) hyaluronic acid (HA) could be a treatment option in OA, however recommendations made in different international guidelines for the non-surgical management of OA are not always concordant with regard to the role of IA injection therapies. Results from a recent Italian Consensus Conference underline how IA-HA to treat OA represents a widely used therapy in Italy...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27895439/comparison-of-two-different-molecular-weight-intra-articular-injections-of-hyaluronic-acid-for-the-treatment-of-knee-osteoarthritis
#15
I Gigis, E Fotiadis, A Nenopoulos, K Tsitas, I Hatzokos
BACKGROUND: Knee osteoarthritis (OA) is an incurable joint disorder, representing a major public health issue. Among options for symptom control, viscosupplementation with hyaluronic acid (HA) had established usefulness in pain and function improvement of the knee. However, it is not clear which form of HA yields better results. MATERIAL AND METHODS: We compared two HA preparations with high (HMW) or low molecular weight (LMW) in terms of pain control and function improvement using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the visual analog scale (VAS) score in patients with knee OA...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27891055/imaging-guidance-improves-the-results-of-viscosupplementation-with-hanox-m-xl-in-patients-with-ankle-osteoarthritis-results-of-a-clinical-survey-in-50-patients-treated-in-daily-practice
#16
Marie Bossert, Daniel Boublil, Jean-Marc Parisaux, Ana-Maria Bozgan, Emmanuel Richelme, Thierry Conrozier
BACKGROUND: The objective of this survey was to assess retrospectively the interest of performing viscosupplementation using imaging guidance in patients suffering from ankle osteoarthritis (OA). PATIENTS AND METHODS: This is a multicenter retrospective survey using a standardized questionnaire. Fifty patients suffering from ankle OA and treated, in daily clinical practice, with a single intra-articular injection of a novel viscosupplement made of a combination of a non-animal cross-linked hyaluronan and mannitol, HANOX M-XL, were included in the survey...
2016: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27860135/joint-lavage-followed-by-viscosupplementation-and-triamcinolone-in-patients-with-severe-haemophilic-arthropathy-objective-functional-results
#17
M U Rezende, F R Andrusaitis, R T Silva, E Okazaki, J D A Carneiro, G C Campos, A F Pailo, R Frucchi, T Pasqualin, P R Villaça
INTRODUCTION: Viscosupplementation can improve function in haemophilia patients. Viscosupplementation results can be improved by prior joint lavage and triamcinolone administration. AIM: To objectively assess whether viscosupplementation and associated triamcinolone use in patients with severe haemophilic arthropathy following joint lavage improves force and balance and reduces bleeding events. METHODS: Fourteen patients with haemophilic knee arthritis with and without the involvement of other joints underwent joint lavage and subsequent injections of Hylan G-F20 and triamcinolone into all affected joints...
November 16, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27848271/improvement-in-condition-specific-and-generic-quality-of-life-outcomes-in-patients-with-knee-osteoarthritis-following-single-injection-synvisc-results-from-the-lobras-study
#18
P Kearey, A E Popple, J Warren, T Davis, N Bellamy
OBJECTIVE: To evaluate the effectiveness of viscosupplementation with single-injection hylan G-F20 (Synvisc-One) in knee osteoarthritis (OA), during routine clinical care, in a 52 week observational study. RESEARCH DESIGN AND METHODS: The LOBRAS study involved a 1 year long, multi-center, quasi-experimental, repeated measures, observational study. Consenting patients in Australia fulfilling inclusion/exclusion criteria under the care of a medical specialist in routine clinical practice were enrolled...
March 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27822391/ultrasound-guided-genicular-nerve-thermal-radiofrequency-ablation-for-chronic-knee-pain
#19
Joshua Wong, Nicholas Bremer, Paul D Weyker, Christopher A J Webb
Osteoarthritis (OA) of the knee is one of the most common joint diseases affecting adults in the United States. For elderly patients with multiple medical comorbidities who do not wish to undergo total knee arthroplasty (TKA), lifestyle modification, pharmacologic management, and injections are the mainstay of therapy. Previously, pain management interventions were limited to intra-articular joint injections and viscosupplementation with hyaluronic acid. Fluoroscopic-guided techniques for radiofrequency ablation (RFA) of the genicular nerves have been previously described and a recent cadaveric study suggests that ultrasound-guided genicular nerve blocks can be performed accurately...
2016: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/27814744/hyaluronic-acid-injection-therapy-for-osteoarthritis-of-the-knee-concordant-efficacy-and-conflicting-serious-adverse-events-in-two-systematic-reviews
#20
Claire E O'Hanlon, Sydne J Newberry, Marika Booth, Sean Grant, Aneesa Motala, Margaret A Maglione, John D FitzGerald, Paul G Shekelle
BACKGROUND: The prevalence of knee osteoarthritis (OA)/degenerative joint disease (DJD) is increasing in the USA. Systematic reviews of treatment efficacy and adverse events (AEs) of hyaluronic acid (HA) injections report conflicting evidence about the balance of benefits and harms. We review evidence on efficacy and AEs of intraarticular viscosupplementation with HA in older individuals with knee osteoarthritis and account for differences in these conclusions from another systematic review...
November 4, 2016: Systematic Reviews
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