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Viscosupplementation

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https://www.readbyqxmd.com/read/28641954/interventional-rheumatology-the-competence-of-brazilian-rheumatologists
#1
Aline Teixeira de Landa, Jamil Natour, Rita Nely Vilar Furtado
OBJECTIVES: Describe Brazilian rheumatologists's competence in interventional rheumatology; assess the association between this ability and demographic and training variables. METHODS: A cross-sectional study with 500 Brazilian rheumatologists. Participants were assessed by self-administered questionnaire consisting of demographics, training, practice in office and knowledge in interventional rheumatology data. RESULTS: 463 participants had their data analyzed...
June 19, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28577705/nonoperative-options-for-management-of-articular-cartilage-disease
#2
REVIEW
Sourav K Poddar, Luke Widstrom
Nonoperative options for articular cartilage injury are pervasive but have not shown to be curative. Recommendations for low-impact exercise and weight loss provide benefit and are a foundation for the treatment of osteoarthritis. Judicious use of NSAIDs and acetaminophen can be appropriate for pain management. Topical NSAIDs may be a treatment option with fewer side effects than its oral counterpart. Additionally, viscosupplementation injections are useful for mild to moderate knee osteoarthritis, whereas short-term pain relief is provided by intra-articular corticosteroid injections...
July 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28554494/effects-of-a-viscosupplementation-therapy-on-rabbit-menisci-in-an-anterior-cruciate-ligament-transection-model-of-osteoarthritis
#3
A Levillain, H Magoariec, C Boulocher, A Decambron, V Viateau, T Hoc
The aim of this study was to evaluate the morphological, microstructural, and mechanical effects of a viscosupplementation therapy on rabbit menisci at an early stage of osteoarthritis (OA). Anterior cruciate ligament transection (ACLT) was performed in twelve male New-Zealand White rabbits on the right knee joint. Six of these twelve rabbits received a mono intra-articular injection of high molecular weight hyaluronic acid (HA) two weeks after ACLT. Six additional healthy rabbits served as controls. Medial menisci were removed from all right knees (n=18) six weeks after ACLT and were graded macroscopically...
May 17, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28549430/reduction-of-the-serum-levels-of-a-specific-biomarker-of-cartilage-degradation-coll2-1-by-hyaluronic-acid-kartilage%C3%A2-cross-compared-to-placebo-in-painful-knee-osteoarthritis-patients-the-epikart-study-a-pilot-prospective-comparative-randomized-double-blind
#4
Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette, François Rannou
BACKGROUND: Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few clinical studies have focused on its effects on biologicals markers of cartilage metabolism. In this study, we assessed the effect of an intra-articular injection of a reticulated hyaluronic acid compound on the level of a specific biomarker of type II collagen degradation...
May 26, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28545178/hylan-gf-20-viscosupplementation-in-the-treatment-of-symptomatic-osteoarthritis-of-the-knee-clinical-effect-survivorship-at-5-years
#5
Tarek Boutefnouchet, Guru Puranik, Esther Holmes, Karl M Bell
Purpose: Controversies remain surrounding the choice of hyaluronic acid products and patient selection. A study was conducted to report the long-term survivorship of intra-articular injection effect of high molecular weight hyaluronic preparation hylan GF-20 (Synvisc-One) for patients with symptomatic knee osteoarthritis. Materials and Methods: A retrospective observational analysis of a single therapeutic series was carried out. The analysis was conducted to determine therapeutic effect survivorship taking arthroplasty and any other surgical interventions as endpoint results...
June 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28450242/modulating-carbohydrate-based-hydrogels-as-viscoelastic-lubricant-substitute-for-articular-cartilages
#6
Gesmi Milcovich, Filipe E Antunes, Rossella Farra, Gabriele Grassi, Mario Grassi, Fioretta Asaro
Viscosupplementation is a therapeutic approach for osteoarthritis treatment, where the synovial fluid, the natural lubricant of the joints, is replaced by viscoelastic solutions with rheological properties comparable or better than the starting material. This study presents the development of an innovative platform for viscosupplementation, based on the optimization of polysaccharide-based colloidal hydrogel, aiming to reduce on-site enzyme degradation and enhance the possibility of hyaluronic acid substitution with alternative biomaterials...
April 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28429341/hyalone%C3%A2-in-the-treatment-of-symptomatic-hip-oa-data-from-the-antiage-register-seven-years-of-observation
#7
A Migliore, U Massafra, B Frediani, E Bizzi, E Sinelnikov Yzchaki, G Gigliucci, M Cassol, S Tormenta
OBJECTIVE: Several studies on knee osteoarthritis suggest that the intra-articular administration of hyaluronic acid products may be a relevant option in the management of patients with persistent pain. The aim of this study is to report the data of efficacy of US-guided HyalOne®/Hyalubrix® 60 injections in a large population of patients with hip osteoarthritis, repeated at least 2 times per year for up to seven years. PATIENTS AND METHODS: This is a prospective, post-marketing, cohort study...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28397753/hip-arthropathy-in-haemophilia
#8
Christian Carulli, Anna Rosa Rizzo, Massimo Innocenti
Hip arthropathy in haemophilic patients is disabling for hip and other common target joints. Even if bleedings in the hip are not frequent, femoroacetabular alterations may affect the functional ability of patients at a very young age. A haematologic prophylaxis combined with an adequate lifestyle and regular and low-traumatic physical activity are the keys to preventing such arthropathy. In the early stages of arthropathy, anti-inflammatory drugs and physical therapy may be sufficient to limit its progression...
April 8, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28392718/single-arm-open-label-study-of-durolane-nasha-nonanimal-hyaluronic-acid-for-the-treatment-of-osteoarthritis-of-the-thumb
#9
Eloisa Velasco, Mª Victoria Ribera, Joan Pi
INTRODUCTION: Osteoarthritis of the trapeziometacarpal (TMC) joint of the thumb - also known as rhizarthrosis - is painful and has a significant impact on quality of life. Intra-articular injection of hyaluronic acid may potentially meet the need for effective, minimally invasive intervention in patients not responding adequately to initial treatment. We aimed to confirm the safety and effectiveness of viscosupplementation with Durolane (NASHA nonanimal hyaluronic acid) in rhizarthrosis...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28372297/chitosan-a-promising-polymer-for-cartilage-repair-and-viscosupplementation
#10
Fanny Comblain, Guillem Rocasalbas, Sandrine Gauthier, Yves Henrotin
Osteoarthritis (OA) is a painful, degenerative and inflammatory disease that affects the entire synovial joints. Nowadays, no cure exists, and the pharmacological treatments are limited to symptoms alleviation. There is a need for a new efficient and safe treatment. Viscosupplementation is a process that aims to restore the normal rheological properties of synovial fluid. For the past years, hyaluronic acid was usually used but this molecule has some limitations including the short residency time in joint cavity...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28328935/intra-articular-hyaluronic-acid-in-the-management-of-knee-osteoarthritis-pharmaco-economic-study-from-the-perspective-of-the-national-health-insurance-system
#11
Thierry Thomas, Françoise Amouroux, Patrice Vincent
INTRODUCTION: Pharmaco-economic data on the management of knee osteoarthritis (OA) with intra articular hyaluronic acid (IA HA) viscosupplementation is limited. We contrasted IA HA with non-steroidal anti-inflammatory drugs (NSAIDs). METHODS: Observational, prospective and multicenter study comparing treatments of knee OA costs and efficacy with either NSAIDs alone, or hyaluronic acid (Arthrum H 2%®), during a 6-month follow-up period. The investigators were pharmacists who recorded data on disease, drug consumption and healthcare circuit...
2017: PloS One
https://www.readbyqxmd.com/read/28326422/late-hemorrhagic-pseudoseptic-arthritis-encountered-during-total-knee-arthroplasty-due-to-hyaluronic-acid-viscosupplementation
#12
Jeremy M Korsh, William Paul Bassett, Donald R Polakoff
Osteoarthritis (OA) is the most common form of arthritis and affects approximately one-third of people in the United Sates aged 65 years and older. Since 2013, the American Academy of Orthopaedic Surgeons has not been able to recommended using hyaluronic acid for patients with symptomatic OA of the knee. Subsequent publications have also cautioned against the use of viscosupplementation based on lack of efficacy and the potential for harm. We present a case of late hemorrhagic pseudoseptic arthritis encountered during TKA due to hyaluronic acid viscosupplementation...
December 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28326213/a-fatal-sepsis-caused-by-hyaluronate-knee-injection-how-much-the-medical-history-and-the-informed-consent-might-be-important
#13
F Manfreda, G Rinonapoli, A Nardi, P Antinolfi, A Caraffa
The incidence of Osteoarthritis (OA) is gradually increasing worldwide due to two main reasons: longer life expectation and increased functional demand. Several treatment options have been proposed for this disease. Conservative treatment has the goal to improve the quality of life, reduce pain, and prevent the progression of the disease. Hyaluronate viscosupplementation is one of the most used infiltrative treatments for OA, but, despite its common use, clinical efficacy is still under question. Though adverse reactions for this medical option are actually rare, septic arthritis is a very scaring complication...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28304363/knee-viscosupplementation-cost-effectiveness-analysis-between-stabilized-hyaluronic-acid-in-a-single-injection-versus-five-injections-of-standard-hyaluronic-acid
#14
COMPARATIVE STUDY
Francisco J Estades-Rubio, Alvaro Reyes-Martín, Victor Morales-Marcos, Mercedes García-Piriz, Juan J García-Vera, Macarena Perán, Juan A Marchal, Elvira Montañez-Heredia
Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score greater than 7, with a homogeneous distribution of age, sex, BMI, and duration of disease, were included in this study...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28293455/viscosupplementation-of-the-knee-three-cases-of-acute-pseudoseptic-arthritis-with-painful-and-irritating-complications-and-a-literature-review
#15
Murat Aydın, Murat Arıkan, Güray Toğral, Onur Varış, Güle Aydın
Acute pseudoseptic arthritis is a very rare complication that is associated with intra-articular hyaluronic acid injections, which normally involve minimal risk. The most common adverse events that are caused by hyaluronic acid injections are inflammatory reactions or flares at the injection site. In this study, we described three cases of acute pseudoseptic arthritis that was caused by hyaluronic acid; the symptoms in these cases were reminiscent of acute septic arthritis. Moreover, we performed a literature review on pseudoseptic arthritis following hyaluronic acid injections to determine the manner in which this condition can be described, diagnosed, and treated...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28291178/comparison-of-single-intra-articular-injection-of-novel-hyaluronan-hya-joint-plus-with-synvisc-one-for-knee-osteoarthritis-a-randomized-controlled-double-blind-trial-of-efficacy-and-safety
#16
RANDOMIZED CONTROLLED TRIAL
Shu-Fen Sun, Chien-Wei Hsu, Huey-Shyan Lin, I-Hsiu Liou, Yin-Han Chen, Chia-Ling Hung
BACKGROUND: Viscosupplementation has been widely used for the treatment of knee osteoarthritis. Because we found no well-controlled trial comparing single-injection regimens of hyaluronan for knee osteoarthritis, we compared the efficacy and safety of a single intra-articular injection of a novel cross-linked hyaluronan (HYA-JOINT Plus) with a single injection of Synvisc-One in patients with knee osteoarthritis. METHODS: In a prospective, randomized, controlled, double-blind trial with a 6-month follow-up, 132 patients with knee osteoarthritis (Kellgren-Lawrence grade 2 or 3) were randomized to receive 1 intra-articular injection of 3 mL of HYA-JOINT Plus (20 mg/mL) (n = 66) or 6 mL of Synvisc-One (8 mg/mL) (n = 66)...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28238583/intra-articular-knee-injections-before-total-knee-arthroplasty-outcomes-and-complication-rates
#17
Brent A Kokubun, Gregory C Manista, P Maxwell Courtney, Sean M Kearns, Brett R Levine
BACKGROUND: The relationship between intra-articular injections and complication rates after total knee arthroplasty (TKA) remains controversial. This study's purpose was to determine the relationship between the number and timing of intra-articular injections with complications and outcomes after TKA from a single surgeon's database. METHODS: We retrospectively reviewed a series of 442 patients who underwent primary TKA from 2008-2015. Patient demographics, comorbidities, number and timing of ipsilateral intra-articular injections, and preoperative and postoperative functional outcome scores were recorded...
February 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28128473/obesity-and-radiological-severity-are-associated-with-viscosupplementation-failure-in-patients-with-knee-osteoarthritis
#18
Florent Eymard, Xavier Chevalier, Thierry Conrozier
Viscosupplementation (VS) is still controversial. One of the key points is the lack of well-identified factors of response. We aimed to identify clinical and radiological factors associated with lack of relevant response after intra-articular (IA) hyaluronic acid (HA) injections in symptomatic knee osteoarthritis patients. A post hoc analysis of the HAV-2012 trial, a controlled, multicentre, double-blind, randomized, non-inferiority trial comparing 3 weekly IA injections of HA (HAnox-M or BioHA) for symptomatic tibiofemoral OA was performed...
January 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28117254/prospective-evaluation-of-intra-articular-sodium-hyaluronate-injection-in-the-ankle
#19
Evelyn P Murphy, Mark Curtin, Niall P McGoldrick, Gerard Thong, Stephen R Kearns
Viscosupplementation by injection of hyaluronic acid into the ankle can be used to provide pain relief and to delay the need for surgery in patients with osteoarthritis of the ankle. In the present investigation, we prospectively evaluated 50 consecutive patients (25 males and 25 females) undergoing a 3-injection protocol of sodium hyaluronate viscosupplementation in the ankle from January 2014 to January 2015. The Foot and Ankle Outcomes Score was used to compare the patients' pre- and post-treatment opinions about their ankle problems...
March 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28092250/-osteoarthrosis-implementation-of-current-diagnostic-and-therapeutic-algorithms
#20
Gilberto Meza-Reyes, Jorge Aldrete-Velasco, Rolando Espinosa-Morales, Fernando Torres-Roldán, Alejandro Díaz-Borjón, Manuel Robles-San Román
In the modern world, among the different clinical presentations of osteoarthritis, gonarthrosis and coxarthrosis exhibit the highest prevalence. In this paper, the characteristics of osteoarthritis and the different scales of assessment and classification of this pathology are exposed, to provide an exhibition of current evidence generated around diagnostic algorithms and treatment of osteoarthritis, with emphasis set out in the knee and hip, as these are the most frequent; a rational procedure for monitoring patients with osteoarthritis based on characteristic symptoms and the severity of the condition is also set...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
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