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https://www.readbyqxmd.com/read/28806942/impact-of-inpatient-care-in-emergency-department-on-outcomes-a-quasi-experimental-cohort-study
#1
Aisha Lateef, Soo Hoon Lee, Dale Andrew Fisher, Wei-Ping Goh, Hui Fen Han, Uma Chandra Segara, Tiong Beng Sim, Malcolm Mahadehvan, Khean Teik Goh, Noel Cheah, Aymeric Yt Lim, Phillip H Phan, Reshma A Merchant
BACKGROUND: Hospitals around the world are faced with the issue of boarders in emergency department (ED), patients marked for admission but with no available inpatient bed. Boarder status is known to be associated with delayed inpatient care and suboptimal outcomes. A new care delivery system was developed in our institution where boarders received full inpatient care from a designated medical team, acute medical team (AMT), while still residing at ED. The current study examines the impact of this AMT intervention on patient outcomes...
August 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28800849/rnai-mediated-silencing-of-map-kinase-signalling-genes-fmk1-hog1-and-pbs2-in-fusarium-oxysporum-reduces-pathogenesis-on-tomato-plants
#2
Manish Pareek, Manchikatla Venkat Rajam
Fusarium oxysporum is a soil-borne plant fungal pathogen, and causes colossal losses in several crop plants including tomato. Effective control measures include the use of harmful fungicides and resistant cultivars, but these methods have shown limited success. Conventional methods to validate fungal pathogenic genes are labour intensive. Therefore, an alternative strategy is required to efficiently characterize unknown pathogenic genes. RNA interference (RNAi) has emerged as a potential tool to functionally characterize novel fungal pathogenic genes and also to control fungal diseases...
September 2017: Fungal Biology
https://www.readbyqxmd.com/read/28799218/synergy-and-mechanism-of-action-of-%C3%AE-mangostin-and-ceftazidime-against-ceftazidime-resistant-acinetobacter-baumannii
#3
T Pimchan, D Maensiri, G Eumkeb
To address the resistance of Acinetobacter baumannii to β-lactam antibiotics, combination therapy between different antibiotic classes is increasingly used. The antibacterial activity of α-mangostin (AMT) alone or in combination with ceftazidime (CTZ) was investigated against ceftazidime-resistant A. baumannii DMST 45378 (CRAB). Initial screening showed that A. baumannii strains possessed AmpC β-lactamase (AmpC), Extended-Spectrum Beta-Lactamase (ESBL) and metallo-β-lactamases (MBL). Minimum inhibitory concentrations (MICs) of >800 μg ml(-1) against individual antibiotics...
August 11, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28796101/use-of-the-ipsilateral-anteromedial-thigh-flap-for-immediate-rescue-of-nonviable-anterolateral-thigh-flaps-in-head-and-neck-cancer-reconstruction
#4
Hsu-Tang Cheng, Jin-Yi Tian, Yung-Chang Hsu, Hsin-Han Chen, Sophia Chia-Ning Chang
BACKGROUND: It is not always possible to use the anatomically variable free anterolateral thigh (ALT) flap for reconstructive surgery. An anteromedial thigh (AMT) flap serves as a good alternative, and shares the same vascular pedicle as the ALT flap. METHODS: Of 698 reconstructions performed in 2006 to 2013 following head and neck tumor ablation surgery, ALT flaps were used in 653 patients. Eighteen free AMT flaps were harvested to replace variant nonviable ALT flaps...
August 8, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28747225/epidemiology-and-outcomes-of-people-with-dementia-delirium-and-unspecified-cognitive-impairment-in-the-general-hospital-prospective-cohort-study-of-10-014-admissions
#5
Emma L Reynish, Simona M Hapca, Nicosha De Souza, Vera Cvoro, Peter T Donnan, Bruce Guthrie
BACKGROUND: Cognitive impairment of various kinds is common in older people admitted to hospital, but previous research has usually focused on single conditions in highly-selected groups and has rarely examined associations with outcomes. This study examined prevalence and outcomes of cognitive impairment in a large unselected cohort of people aged 65+ with an emergency medical admission. METHODS: Between January 1, 2012, and June 30, 2013, admissions to a single general hospital acute medical unit aged 65+ underwent a structured specialist nurse assessment (n = 10,014)...
July 27, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28739371/trans-biome-diversity-in-australian-grass-specialist-lizards-diplodactylidae-strophurus
#6
Rebecca J Laver, Stuart V Nielsen, Dan F Rosauer, Paul M Oliver
Comparisons of biodiversity patterns within lineages that occur across major climate gradients and biomes, can provide insights into the relative roles that lineage history, landscape and climatic variation, and environmental change have played in shaping regional biotas. In Australia, while there has been extensive research into the origins and patterns of diversity in the Australian Arid Zone (AAZ), how diversity is distributed across this biome and the Australian Monsoonal Tropics (AMT) to the north, has been less studied...
July 21, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28717059/pharmacological-effects-of-a-vitamin-k1-2-3-epoxide-reductase-vkor-inhibitor-3-acetyl-5-methyltetronic-acid-on-cisplatin-induced-fibrosis-in-rats
#7
Masashi Uchida, Tomoya Miyoshi, Yohei Miyamoto
Cisplatin (CDDP) is a chemotherapeutic agent that is widely used in the treatment of lymphomas and solid malignancies. However, its clinical usage is limited by its severe side effects in the kidneys. Glomerular and tubular injuries in the kidneys commonly progress to interstitial fibrosis and, ultimately, the end stage of renal failure. We previously reported that 3-acetyl-5-methyltetronic acid (AMT) had inhibitory effects on rat renal vitamin K1 2,3-epoxide reductase (VKOR) in vitro and also suppressed mesangial cell proliferation and, consequently, the formation of fibrosis via the vitamin K-dependent activation of the growth arrest-specific 6 (Gas6)/Axl pathway in anti-Thy-1 glomerulonephritis (Thy-1 GN) in rats...
July 16, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28714825/quadriceps-and-patient-reported-function-in-acl-reconstructed-patients-a-principal-component-analysis
#8
Grant E Norte, Jay N Hertel, Susan A Saliba, David R Diduch, Joseph M Hart
CONTEXT: Assessment of physical function for individuals after ACL reconstruction (ACL-R) is complex and warrants the use of diverse evaluation strategies. To maximize the efficiency of assessment, there is a need to identify tests that provide the most meaningful information about this population. OBJECTIVE: To investigate underlying constructs of quadriceps muscle function that uniquely describe aspects of performance in patients after ACL-R, and establish clinical thresholds for measures able to classify patients with and without ACL-R...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28704317/comparison-of-collagen-cross-linking-and-amniotic-membrane-transplantation-in-an-experimental-alkali-burn-rabbit-model
#9
Sevgi Subasi, Ozgul Altintas, Melda Yardimoglu, Yusufhan Yazir, Suleyman Karaman, Selenay Furat Rencber, Kubra Kavram
PURPOSE: To compare the effects of collagen cross-linking (CXL) and amniotic membrane transplantation (AMT) on acute corneal alkali burns. METHODS: After establishment of an alkali burn model, 32 rabbits were divided into 4 groups: control group, AMT group, CXL group, and AMT + CXL (combined) group. Clinical parameters, including epithelial wound, opacity, ulceration, and neovascularization, were evaluated on postinjury days 1, 7, 14, and 18. Histological parameters were examined in hematoxylin/eosin (H&E) and Masson trichrome-stained corneal sections...
July 11, 2017: Cornea
https://www.readbyqxmd.com/read/28702912/the-sugarcane-herbicide-ametryn-induces-oxidative-stress-and-developmental-abnormalities-in-zebrafish-embryos
#10
Monica A M Moura, Rhaul Oliveira, Claudio M Jonsson, Inês Domingues, Amadeu M V M Soares, António J A Nogueira
Ametryn (AMT) is one of the most widely used herbicides in tropical sugarcane crops, the main culture of São Paulo State, Brazil. It is known as a diffuse pollutant, being found in surface water and sediment of water bodies adjacent to the crop fields. In the present study, the toxicity of AMT to zebrafish (Danio rerio) embryos was evaluated using developmental and biochemical endpoints. At the biochemical level, lactate dehydrogenase responded at the lowest concentration tested (4 μg L(-1)) indicating a high demand of energy required to cope with the stress condition...
July 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28682914/multiple-pedicled-flaps-cover-for-large-defects-following-resection-of-malignant-tumors-with-partition-concept
#11
Chenyang Ji, Ruiting Li, Grace Shen, Jinming Zhang, Weiqiang Liang
Large defects after skin malignant tumors resection were difficult to repair. We introduced a partition concept, in which the large defects were divided into several subunits, and each subunit was repaired by a certain pedicled flap to achieve a complete coverage.Between May 2012 and Oct 2016, 8 patients with skin malignant tumors underwent radical resection. Prior to surgery, the dimension of the potential defect after tumor ablation was estimated and outlined. After evaluation, the partition concept was applied and the defects were divided into several subunits...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28667402/phylogenetic-structural-and-functional-characterization-of-amt3-1-an-ammonium-transporter-induced-by-mycorrhization-among-model-grasses
#12
Sally Koegel, Delphine Mieulet, Sefer Baday, Odile Chatagnier, Moritz F Lehmann, Andres Wiemken, Thomas Boller, Daniel Wipf, Simon Bernèche, Emmanuel Guiderdoni, Pierre-Emmanuel Courty
In the arbuscular mycorrhizal (AM) symbiosis, plants satisfy part of their nitrogen (N) requirement through the AM pathway. In sorghum, the ammonium transporters (AMT) AMT3;1, and to a lesser extent AMT4, are induced in cells containing developing arbuscules. Here, we have characterized orthologs of AMT3;1 and AMT4 in four other grasses in addition to sorghum. AMT3;1 and AMT4 orthologous genes are induced in AM roots, suggesting that in the common ancestor of these five plant species, both AMT3;1 and AMT4 were already present and upregulated upon AM colonization...
June 30, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/28666237/excitability-of-the-masseter-inhibitory-reflex-after-high-frequency-rtms-over-the-motor-cortex-a-study-in-healthy-humans
#13
Congcong Cui, Yuhan Song, Xiao Fan, Qian Guo, Jijun Wang, Weicai Liu
OBJECTIVE: We aimed to investigate the influence of high frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex on excitability of the masseter inhibitory reflex (MIR) in healthy subjects. Our goal in conducting this study was to obtain a better understanding of the subcortical and cortical networks related to the excitability of the central masticatory pathway. METHODS: Twenty healthy volunteers participated in this study. MIRs were evaluated both before and after high frequency rTMS to elicit motor evoked potentials (MEPs) using single- and double-shock techniques over the motor cortex...
June 17, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28638330/flat-vs-expressive-storytelling-young-children-s-learning-and-retention-of-a-social-robot-s-narrative
#14
Jacqueline M Kory Westlund, Sooyeon Jeong, Hae W Park, Samuel Ronfard, Aradhana Adhikari, Paul L Harris, David DeSteno, Cynthia L Breazeal
Prior research with preschool children has established that dialogic or active book reading is an effective method for expanding young children's vocabulary. In this exploratory study, we asked whether similar benefits are observed when a robot engages in dialogic reading with preschoolers. Given the established effectiveness of active reading, we also asked whether this effectiveness was critically dependent on the expressive characteristics of the robot. For approximately half the children, the robot's active reading was expressive; the robot's voice included a wide range of intonation and emotion (Expressive)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28636413/tea-consumption-is-associated-with-cognitive-impairment-in-older-chinese-adults
#15
Ying-Jie Gu, Chun-Hong He, Su Li, Shu-Yi Zhang, Sheng-Yu Duan, Hong-Peng Sun, Yue-Ping Shen, Yong Xu, Jie-Yun Yin, Chen-Wei Pan
OBJECTIVE: To explore the association between tea consumption and cognitive impairment (CoI). METHODS: 4579 adults (≥60 years) from the Weitang Geratric Diseases Study were assessed for characteristics of tea consumption and cognitive function by administering questionnaires and the Abbreviated Mental Test (AMT), respectively. We divided the subjects into normal cognitive function group (AMT score ≥8) and CoI group (AMT score ≤7).   The association between tea consumption and risk of CoI was determined by logistic regression models...
June 21, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28634154/improving-consensus-scoring-of-crowdsourced-data-using-the-rasch-model-development-and-refinement-of-a-diagnostic-instrument
#16
Christopher John Brady, Lucy Iluka Mudie, Xueyang Wang, Eliseo Guallar, David Steven Friedman
BACKGROUND: Diabetic retinopathy (DR) is a leading cause of vision loss in working age individuals worldwide. While screening is effective and cost effective, it remains underutilized, and novel methods are needed to increase detection of DR. This clinical validation study compared diagnostic gradings of retinal fundus photographs provided by volunteers on the Amazon Mechanical Turk (AMT) crowdsourcing marketplace with expert-provided gold-standard grading and explored whether determination of the consensus of crowdsourced classifications could be improved beyond a simple majority vote (MV) using regression methods...
June 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28615805/free-anteromedial-thigh-perforator-flap-complementing-and-completing-the-anterolateral-thigh-flap
#17
Dushyant Jaiswal, Amol Ghalme, Prabha Yadav, Vinaykant Shankhdhar, Akshay Deshpande
OBJECTIVE: Theobjective of this study was to determine the indications, utility, advantages and surgical approach for the anteromedial thigh (AMT) flap. MATERIALS AND METHODS: We reviewed the records of the patients in whom the AMT flap was used for head and neck reconstruction. We use an anterior approach to harvest the anterolateral thigh (ALT) flap with a non-committal straight line incision. This preserves both ALT and AMT flap territories intact, and further decision is based on the intraoperative anatomy of perforator and pedicle...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28589659/validity-and-reliability-of-abbreviated-mental-test-score-amts-among-older-iranian
#18
Mahshid Foroughan, Lars-Olof Wahlund, Zahra Jafari, Mehdi Rahgozar, Ida G Farahani, Vahid Rashedi
BACKGROUND: Cognitive impairment is common among older people and is associated with increased morbidity and mortality. The main aim of this study was to evaluate the validity of the Persian version of the Abbreviated Mental Test Score (AMTS) as a screening tool for dementia. METHODS: Data were obtained from a cross-sectional study. One hundred and one older adults who were members of Iranian Alzheimer Association and 101 of their siblings were entered into this study by convenient sampling...
June 6, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28586778/autobiographical-memory-in-bipolar-disorder-and-its-link-to-neuropsychological-functioning
#19
Esther Quinlivan, Mattea Dallacker, Babette Renneberg, Elisa Strasser, Jana Fiebig, Thomas J Stamm
OBJECTIVE: The aim of this study was to examine the specificity of autobiographical memory (AM) in bipolar disorder (BD) and to investigate the association between AM and neuropsychological functions. METHOD: Twenty bipolar patients and 22 matched healthy controls (HCs) were included in this study. AM was assessed with an extended version of the Autobiographical Memory Test (AMT) including rejection cue words. A neuropsychological test battery was used to examine verbal memory, executive functions, and attention...
June 7, 2017: Psychopathology
https://www.readbyqxmd.com/read/28577267/cognitive-training-in-alzheimer-s-disease-a-controlled-randomized-study
#20
A R Giovagnoli, V Manfredi, A Parente, L Schifano, S Oliveri, G Avanzini
This controlled randomized single-blind study evaluated the effects of cognitive training (CT), compared to active music therapy (AMT) and neuroeducation (NE), on initiative in patients with mild to moderate Alzheimer's disease (AD). Secondarily, we explored the effects of CT on episodic memory, mood, and social relationships. Thirty-nine AD patients were randomly assigned to CT, AMT, or NE. Each treatment lasted 3 months. Before, at the end, and 3 months after treatment, neuropsychological tests and self-rated scales assessed initiative, episodic memory, depression, anxiety, and social relationships...
August 2017: Neurological Sciences
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