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https://www.readbyqxmd.com/read/29333918/modified-second-stage-hughes-tarsoconjunctival-reconstruction-for-lower-eyelid-defects
#1
Shruti Aggarwal, Christopher T Shah, Maria Kirzhner
To describe a novel technique utilizing an amniotic membrane graft (AMT) to create the mucocutaneous portion of the lower eyelid margin in a modified Hughes eyelid reconstruction for secondary revision or prevention of a hyperemic, hypertrophic conjunctival margin with excessive discharge. This was a retrospective, non-comparative interventional study. Thirty consecutive patients who underwent a modified Hughes reconstruction were included. The first step of the reconstruction was performed in a standard fashion using a tarsoconjunctival flap from the ipsilateral upper eyelid...
January 15, 2018: Orbit
https://www.readbyqxmd.com/read/29328790/hospital-stay-and-blood-transfusion-in-elderly-patients-with-hip-fractures
#2
Efthymios Iliopoulos, Sohail Yousaf, Hazel Watters, Arshad Khaleel
Neck of femur (NOF) fractures in elderly patients are the most frequent condition which an orthopaedic surgeon confronts nowadays. The incidence of these fractures is increasing as the population continues to age. These patients absorb the majority of the resources in the hospitals, as their healthcare demands are increased. This study included all patients who were admitted to our hospital between January and October 2015 following a neck of femur fracture. A total of 336 patients were included (72.3% female)...
December 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29323112/signaling-ammonium-across-membranes-through-an-ammonium-sensor-histidine-kinase
#3
Tobias Pflüger, Camila F Hernández, Philipp Lewe, Fabian Frank, Haydyn Mertens, Dmitri Svergun, Manfred W Baumstark, Vladimir Y Lunin, Mike S M Jetten, Susana L A Andrade
Sensing and uptake of external ammonium is essential for anaerobic ammonium-oxidizing (anammox) bacteria, and is typically the domain of the ubiquitous Amt/Rh ammonium transporters. Here, we report on the structure and function of an ammonium sensor/transducer from the anammox bacterium "Candidatus Kuenenia stuttgartiensis" that combines a membrane-integral ammonium transporter domain with a fused histidine kinase. It contains a high-affinity ammonium binding site not present in assimilatory Amt proteins. The levels of phosphorylated histidine in the kinase are coupled to the presence of ammonium, as conformational changes during signal recognition by the Amt module are transduced internally to modulate the kinase activity...
January 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29304759/a-novel-compound-heterozygous-variant-identified-in-gldc-gene-in-a-chinese-family-with-non-ketotic-hyperglycinemia
#4
Yiming Lin, Zhenzhu Zheng, Wenjia Sun, Qingliu Fu
BACKGROUND: Non-ketotic hyperglycinemia (NKH) is a rare, devastating autosomal recessive disorder of glycine metabolism with a very poor prognosis. Currently, few studies have reported genetic profiling of Chinese NKH patients. This study aimed to identify the genetic mutations in a Chinese family with NKH. METHODS: A Chinese family of Han ethnicity, with three siblings with NKH was studied. Sanger sequencing and multiplex ligation-dependent probe amplification combined with SYBR green real-time quantitative PCR was used to identify potential mutations in the GLDC, AMT and GCSH genes...
January 5, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29300369/corrigendum-the-genetic-basis-of-classic-nonketotic-hyperglycinemia-due-to-mutations-in-gldc-and-amt
#5
Curtis R Coughlin, Michael A Swanson, Kathryn Kronquist, Cécile Acquaviva, Tim Hutchin, Pilar Rodríguez-Pombo, Marja-Leena Väisänen, Elaine Spector, Geralyn Creadon-Swindell, Ana M Brás-Goldberg, Elisa Rahikkala, Jukka S Moilanen, Vincent Mahieu, Gert Matthijs, Irene Bravo-Alonso, Celia Pérez-Cerdá, Magdalena Ugarte, Christine Vianey-Saban, Gunter H Scharer, Johan L K Van Hove
This corrects the article DOI: 10.1038/gim.2016.74.
January 4, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29299240/carbon-isotopes-of-c3-herbs-correlate-with-temperature-on-removing-the-influence-of-precipitation-across-a-temperature-transect-in-the-agro-pastoral-ecotone-of-northern-china
#6
Xian-Zhao Liu, Yong Zhang, Zhen-Guo Li, Teng Feng, Qing Su, Yan Song
Plant δ13C-temperature (δ-T) relation has been established in many systems and is often used as paleotemperature transfer function. However, it is still unclear about the exact contributions of temperature variation to plant 13C discrimination because of covariation between temperature and precipitation (aridity), which reduces confidence in reconstruction of paleoclimate. In this study, we measured carbon isotope composition (δ13C) of 173 samples of C3 perennial herbs from 22 sites across a temperature gradient along the 400 mm isohyet in the farming-pastoral zone of North China...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29261637/amino-acid-pet-imaging-of-the-early-metabolic-response-during-tumor-treating-fields-ttfields-therapy-in-recurrent-glioblastoma
#7
Edit Bosnyák, Geoffrey R Barger, Sharon K Michelhaugh, Natasha L Robinette, Alit Amit-Yousif, Sandeep Mittal, Csaba Juhász
Tumor-treating fields (TTFields) therapy is a relatively new treatment approach for malignant gliomas. We evaluated if amino acid PET can detect an objective metabolic response to TTFields therapy in recurrent glioblastomas. PET scanning with alpha[C-11]-methyl-L-tryptophan (AMT) before and 2 to 3 months after the start of TTFields treatment showed an interval decrease of tryptophan uptake in the whole tumor (2 patients) or in a portion of the tumor (1 patient). These data demonstrate that TTFields therapy can induce an early metabolic response in recurrent glioblastoma, and this treatment response can be detected by amino acid PET...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29260110/surgical-treatment-outcome-of-medically-refractory-huge-giant-papillary-conjunctivitis
#8
Yien Lai, Gangadhara Sundar, Manotosh Ray
Purpose: To compare the surgical outcome of excision of giant papillae with and without amniotic membrane in a patient with bilateral medically refractory giant papillary conjunctivitis (GPC). Observations: 27-year-old Chinese lady presented with bilateral itchy eyes, discomfort and fullness of upper lids for past two years. She was a long-term contact lens user but stopped completely 2 years ago. Not a known atopic, she had unusually large giant papillae involving both upper tarsal conjunctiva...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29258807/the-intensity-of-continuous-theta-burst-stimulation-but-not-the-waveform-used-to-elicit-motor-evoked-potentials-influences-its-outcome-in-the-human-motor-cortex
#9
Takuya Sasaki, Satoshi Kodama, Naohiko Togashi, Yuichiro Shirota, Yusuke Sugiyama, Shin-Ichi Tokushige, Satomi Inomata-Terada, Yasuo Terao, Yoshikazu Ugawa, Masashi Hamada
BACKGROUND: Responses to continuous theta burst stimulation (cTBS) applied to the human primary motor cortex are highly variable between individuals. However, little is known about how to improve the after-effects of cTBS by adjusting the protocol characteristics. OBJECTIVE: We examined whether current directions adopted in the measurement of cortical motor excitability indexed as motor evoked potentials (MEPs) affect the responses to cTBS. We also tested whether the stimulus intensity of cTBS influences the after-effects...
December 15, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29246900/gene-therapy-with-adeno-associated-virus-vector-5-human-factor-ix-in-adults-with-hemophilia-b
#10
Wolfgang Miesbach, Karina Meijer, Michiel Coppens, Peter Kampmann, Robert Klamroth, Roger Schutgens, Marco Tangelder, Giancarlo Castaman, Joachim Schwäble, Halvard Bonig, Erhard Seifried, Federica Cattaneo, Christian Meyer, Frank W G Leebeek
Hemophilia B gene therapy aims to ameliorate bleeding risk and provide endogenous factor IX (FIX) activity/synthesis through a single treatment, eliminating the requirement for FIX concentrate. AMT-060 combines an adeno-associated virus-5 (AAV5) vector with a liver-specific promoter driving expression of a codon-optimized wild-type human FIX gene. This multi-national, open-label study included ten adults with hemophilia B (FIX ≤2% of normal) and severe-bleeding phenotype. No participants tested positive for AAV5-neutralizing antibodies using a green-fluorescent protein-based assay and all 10 were enrolled...
December 15, 2017: Blood
https://www.readbyqxmd.com/read/29246208/when-it-just-won-t-go-away-oral-artemisinin-monotherapy-in-nigeria-threatening-lives-threatening-progress
#11
Chinazo Ujuju, Jennifer Anyanti, Paul N Newton, Godwin Ntadom
BACKGROUND: Oral artemisinin monotherapy (AMT), an important contributor to multi-drug resistant malaria, has been banned in Nigeria. While oral AMT has scarcely been found for several years now in other malaria-endemic countries, availability has persisted in Nigeria's private sector. In 2015, the ACTwatch project conducted a nationally representative outlet survey. Results from the outlet survey show the extent to which oral AMT prevails in Nigeria's anti-malarial market, and provide key product information to guide strategies for removal...
December 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29233707/phylogenetic-characterization-of-transporter-proteins-in-the-cnidarian-dinoflagellate-symbiosis
#12
Ashley E Sproles, Nathan L Kirk, Sheila A Kitchen, Clinton A Oakley, Arthur R Grossman, Virginia M Weis, Simon K Davy
Metabolic exchange between cnidarians and their symbiotic dinoflagellates is central to maintaining their mutualistic relationship. Sugars are translocated to the host, while ammonium and nitrate are utilized by the dinoflagellates (Symbiodinium spp.). We investigated membrane protein sequences of each partner to identify potential transporter proteins that move sugars into cnidarian cells and nitrogen products into Symbiodinium cells. We examined the facilitated glucose transporters (GLUT), sodium/glucose cotransporters (SGLT), and aquaporin (AQP) channels in the cnidarian host as mechanisms for sugar uptake, and the ammonium and high-affinity nitrate transporters (AMT and NRT2, respectively) in the algal symbiont as mechanisms for nitrogen uptake...
December 9, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29232014/mutations-of-the-glycine-cleavage-system-genes-possibly-affect-the-negative-symptoms-of-schizophrenia-through-metabolomic-profile-changes
#13
Akane Yoshikawa, Fumichika Nishimura, Aya Inai, Yosuke Eriguchi, Masaki Nishioka, Atsuhiko Takaya, Mamoru Tochigi, Yoshiya Kawamura, Tadashi Umekage, Kayoko Kato, Tsukasa Sasaki, Yoshiaki Ohashi, Kazuya Iwamoto, Kiyoto Kasai, Chihiro Kakiuchi
AIM: Hypofunction of N-methyl-D-aspartate receptors (NMDARs) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional defects cause nonketotic hyperglycinemia (NKH), the atypical phenotype of which presents psychiatric symptoms similar to SCZ. Here, we examined the involvement of GCS in SCZ. METHODS: First, to identify the rare variants and the exonic deletions, we re-sequenced all the coding exons and the splice sites of four GCS genes (GLDC, AMT, GCSH, DLD) in 474 patients with SCZ and 475 controls and performed multiplex ligation-dependent probe amplification (MLPA) analysis in SCZ...
December 12, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29215795/uterine-caesarean-closure-techniques-affect-ultrasound-findings-and-maternal-outcomes-a-systematic-review-and-meta-analysis
#14
S I Stegwee, I P M Jordans, L F van der Voet, P M van de Ven, J C F Ket, C B Lambalk, C J M de Groot, W J K Hehenkamp, J A F Huirne
BACKGROUND: Caesarean section (CS) rates are rising globally. Long-term adverse outcomes after CS might be reduced when the optimal uterine closure technique becomes evident. OBJECTIVE: To determine the effect of uterine closure techniques after CS on maternal and ultrasound outcomes. SEARCH STRATEGY: Literature search in electronic databases. SELECTION CRITERIA: Randomised controlled trials (RCTs) or prospective cohort studies that evaluated uterine closure techniques and reported on ultrasound findings, perioperative or long-term outcomes...
December 7, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29173278/comparison-of-the-in-vitro-anthelmintic-effects-of-acacia-nilotica-and-acacia-raddiana
#15
Geneviève Zabré, Adama Kaboré, Balé Bayala, Luciana M Katiki, Lívio Martins Costa-Júnior, Hamidou H Tamboura, Adrien M G Belem, Adibe L Abdalla, Vincent Niderkorn, Hervé Hoste, Helder Louvandini
Gastrointestinal nematodes are a major threat to small ruminant rearing in the Sahel area, where farmers traditionally use bioactive plants to control these worms, including Acacia nilotica and Acacia raddiana. The main aim of this study was to screen the potential anthelmintic properties of aqueous and acetone extracts of leaves of these two plants based on three in vitro assays: (1) the egg hatch inhibition assay (EHA); (2) the larvae exsheathment inhibition assay (LEIA) using Haemonchus contortus as a model; and (3) an adult mortality test (AMT) applied on Caenorhabditis elegans...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29170974/comparative-proteomic-analysis-of-amnion-membrane-transplantation-and-cross-linking-treatments-in-an-experimental-alkali-injury-model
#16
Sevgi Subasi, Ozgul Altintas, Murat Kasap, Nil Guzel, Gurler Akpinar, Suleyman Karaman
PURPOSE: In this study, by using a two-dimensional (2D) electrophoresis-based experimental approach, we aimed at understanding the nature of alkali injuries and the underlying mechanisms. A secondary aim was to compare the effects of cross-linking (CXL) and amnion membrane transplantation (AMT) on corneal protein compositions at the end of the early repair phase after injured with alkali. METHOD: The right corneas of 24 rabbits were injured with a 1 N solution of NaOH...
November 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29133641/simultaneous-use-of-amniotic-membrane-and-mitomycin-c-in-trabeculectomy-for-primary-glaucoma
#17
RANDOMIZED CONTROLLED TRIAL
Usha Yadava, Kirti Jaisingh, Sonal Dangda, Prolima Thacker, Kirti Singh, Yashpal Goel
PURPOSE: This study aimed to propose the role of amniotic membrane transplantation (AMT) as an additional modulator in primary Mitomycin C (MMC)-augmented trabeculectomy. METHODS: This was a randomized prospective interventional study. Forty eyes of 39 adult patients with uncontrolled primary glaucoma were randomly divided into two equal groups. Control group underwent trabeculectomy augmented with MMC while the study group underwent additional AMT. Patients were followed up for 12 months and outcomes measured were intraocular pressure (IOP), need for additional intervention, and bleb morphology...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29132016/children-s-representation-of-abstract-relations-in-relational-array-match-to-sample-tasks
#18
Jean-Rémy Hochmann, Arin S Tuerk, Sophia Sanborn, Rebecca Zhu, Robert Long, Meg Dempster, Susan Carey
Five experiments compared preschool children's performance to that of adults and of non-human animals on match to sample tasks involving 2-item or 16-item arrays that varied according to their composition of same or different items (Array Match-to-Sample, AMTS). They establish that, like non-human animals in most studies, 3- and 4-year-olds fail 2-item AMTS (the classic relational match to sample task introduced into the literature by Premack, 1983), and that robust success is not observed until age 6. They also establish that 3-year-olds, like non-human animal species, succeed only when they are able to encode stimuli in terms of entropy, a property of an array (namely its internal variability), rather than relations among the individuals in the array (same vs...
November 10, 2017: Cognitive Psychology
https://www.readbyqxmd.com/read/29098940/nitrogen-and-phosphorus-removal-processes-under-different-aeration-strength-in-principal-type-tank-of-alternate-multiple-tanks-system-and-process-control
#19
Zheqin Dai, Xiwu Lu, Zhaoqian Jing
The Alternate multiple tanks (AMT) system was originated by Southeast University to meet pressing requirements of new highly-compact sewage treatment with cost-effective balance and automated management. DO and ORP as economic monitoring indicators are closely linked to nutrients variations and controlling strategy. Thus this paper was to investigate the N and P periodic variations and removal mechanisms under different aeration strengths in scope of principal-type tank in AMT, and the relationship between nutrients and DO, ORP...
November 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29068239/a-phytophthora-palmivora-extracellular-cystatin-like-protease-inhibitor-targets-papain-to-contribute-to-virulence-on-papaya
#20
Rebecca Gumtow, Dongliang Wu, Janice Uchida, Miaoying Tian
Papaya fruits, stems and leaves are rich in papain, a cysteine protease that has been shown to mediate plant defense against pathogens and insects. Yet the oomycete Phytophthora palmivora is a destructive pathogen that infects all parts of papaya plants, suggesting that it has evolved cysteine protease inhibitors to inhibit papain to enable successful infection. Out of five putative cystatin-like extracellular protease inhibitors (PpalEPICs) from P. palmivora transcriptomic sequence data, PpalEPIC8 appeared to be unique to P...
October 25, 2017: Molecular Plant-microbe Interactions: MPMI
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