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Simone Miranda da Costa, José Luís Passos Cordeiro, Elizabeth Ferreira Rangel
BACKGROUND: Leishmaniasis represents an important public health problem in Brazil. The continuous process of urbanization and expansion of human activities in forest areas impacts natural habitats, modifying the ecology of some species of Leishmania, as well as its vectors and reservoirs and, consequently, changes the epidemiological pattern that contributes to the expansion of American cutaneous leishmaniasis in Brazil. Here, we discuss Lutzomyia (Nyssomyia) whitmani, the main vector of ACL, transmitting two dermotropic Leishmania species including Leishmania (Viannia) braziliensis and Leishmania (V...
March 7, 2018: Parasites & Vectors
Zaida Rentería-Solís, Marta Kołodziej-Sobocińska, Katharina Riehn
Alaria spp. mesocercariae are commonly found in wild boar and other omnivorous mammals. In Europe, the number of cases presenting Alaria mesocercariae infections has been on the rise in the last years. From October to December 2016, samples of muscle from tongue, neck, and mandibular regions were collected from 1 Eurasian badger (Meles meles) and 14 wild boars (Sus scrofa) hunted in the Białowieża Forest, north-eastern Poland. Using the Alaria migration technique (AMT), Alaria mesocercariae were isolated and morphologically identified in one badger and one wild boar...
March 3, 2018: Parasitology Research
Zhigang Yin, Yuehua Hu, Wei Sun, Chenyang Zhang, Jianyong He, Zhijie Xu, Jingxiang Zou, Changping Guan, Chen Hu Zhang, Qingjun Guan, Shangyong Lin
In the present study, a novel compound 4-Amino-5-mercapto-1,2,4-triazole was first synthesized and its selective adsorption mechanism on the surface of chalcopyrite was comprehensively investigated using UV-vis spectra, Zeta potential, Fourier Transform Infrared Spectroscopy(FTIR), X-ray Photoelectron Spectroscopy Measurements(XPS), and Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and first principle calculations. The experimental and computational results consistently demonstrated that AMT would chemisorb onto the chalcopyrite surface by the formation of a five-membered chelate ring...
February 28, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Jamshed Haneef, Renu Chadha, Vijay Gupta, Sanjay K Mandal
The present work highlights a novel polymorph (form II) of ambrisentan (AMT), a selective endothelin type A (ETA) receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). Form II was isolated by solution crystallization and characterised by differential scanning calorimetry, powder X-ray diffraction, solution calorimetry and aqueous solubility. The single crystal X-ray diffraction shows that it crystallizes in monoclinic system with space group P21/c different from the form I (commercial form)...
February 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
P Huntsman, J M Skeaff, M Pawlak, R Beaudoin
The transformation/dissolution protocol (T/DP) for metals and sparingly soluble metal compounds was applied to determine the transformation/dissolution (T/D) characteristics of yellow tungsten trioxide, WO3; blue tungsten oxide, WOx (x taken as 2.9); tungsten disulphide, WS2; tungsten metal, W; three samples of tungsten carbide, WC; sodium tungstate, Na2WO4 · 2H2O; ammonium paratungstate (APT), (NH4)10(H2W12O42) · 4H2O; and ammonium metatungstate (AMT), (NH4)6(H2W12O40) · 3H2O. The T/D data were used to derive aquatic hazard classification outcomes under the UN GHS and EU CLP schemes by comparing the data with selected acute and chronic ecotoxicity reference values (ERVs) of 31 and 3...
February 21, 2018: Integrated Environmental Assessment and Management
Raed Behbehani, Hussain Adnan, Abdullah Abu Al-Hassan, Ali Al-Salahat, Raed Alroughani
BACKGROUND: Multiple sclerosis is an inflammatory demyelinating disease characterized by progressive axonal loss affecting mainly the inner retinal layers. Optical coherence tomography (OCT) provides in-vivo quantification of the retinal layers and allows measuring progressive retinal changes. Our objective was to assess the longitudinal changes in the retina using spectral domain OCT (SDOCT) and to identify independent predictors affecting retinal thinning in MS patients. METHODS: A prospective study in a tertiary care MS center was conducted to study the longitudinal retinal changes in MS patients...
February 11, 2018: Multiple Sclerosis and related Disorders
Jing Zhong, Bowen Wang, Saiqun Li, Yuqing Deng, Haixiang Huang, Ling Chen, Jin Yuan
Fungal keratitis is a severe and common ocular infectious disease. The present study evaluated the efficiency of full-thickness conjunctival flap covering surgery with amniotic membrane transplantation (FCCS + AMT) as a transitional surgery for severe fungal keratitis. A total of 17 patients with severe fungal keratitis without corneal perforation underwent FCCS + AMT between January 2010 and December 2015. The pathogenic factors, preoperative diagnosis and postoperative prognosis of FCCS + AMT at 3 months were evaluated...
March 2018: Experimental and Therapeutic Medicine
Hanqing Guo, Nu Wang, Tami R McDonald, Anke Reinders, John M Ward
Plant ammonium transporters in the AMT/MEP/Rh superfamily have only been previously characterized in flowering plants (angiosperms). Plant AMT1s are electrogenic, while plant AMT2s are electroneutral and MEP and Rh transporters in other organisms are electroneutral. We analyzed the transport function of MpAMT1;2 from the basal land plant Marchantia polymorpha, a liverwort. MpAMT1;2 was shown to localize to the plasma membrane in Marchantia gametophyte thallus by stable transformation using a C-terminal citrine fusion...
February 12, 2018: Plant & Cell Physiology
Heng-Dao Lin, Li-Sung Hsu, Chih-Ching Chien, Ssu-Ching Chen
Ametrym (AMT) is the most widely used herbicide and frequently detected in the aquatic environment. AMT also represent a potential health risk to aquatic organisms and animals, including humans. However, little data are available on their toxicity to zebrafish (Danio rerio). The aim of the present study was to evaluate the toxicological effects of AMT exposure on zebrafish embryos. In the acute toxicity test, 6 hpf embryos were exposed to various concentrations of AMT for 24 or 48 h. The results indicated that AMT induced malformation in larvae...
February 10, 2018: Environmental Toxicology
Tom J Barry, Keisuke Takano, Yannick Boddez, Filip Raes
OBJECTIVE/BACKGROUND: Sleep can have an important influence on memory. However, it is unclear whether there is any relation between sleep quality and the specificity with which autobiographical memories are retrieved, a key factor associated with vulnerability for, and the presence of, depression and other psychiatric diagnoses. The present study provides the first investigation of the association between sleep quality and autobiographical memory specificity. PARTICIPANTS AND METHOD: Fifty-four unselected community participants completed the Autobiographical Memory Test (AMT) to assess memory specificity, while subjective and objective measures of total sleep time and sleep onset latency were provided through a daily diary and an actigraphy wristwatch worn for a week...
February 9, 2018: Behavioral Sleep Medicine
Anna Kańtoch, Barbara Gryglewska, Jadwiga Wójkowska-Mach, Piotr Heczko, Tomasz Grodzicki
BACKGROUND: The prevalence of cardiovascular diseases among nursing home residents is high but little is known whether pharmacologic therapy recommended by actual medication guidelines is followed by facility's staff. AIM: To evaluate the adherence to actual guidelines for treatment of cardiovascular diseases among older adult residents of long-term care (LTC) facilities. MATERIAL AND METHODS: The cross-sectional study was performed from December 2009 to November 2010 among 189 elderly residents aged ≥60 years in 3 LTC facilities in Poland: 1 long-term care hospital (LTCH) and 2 nursing homes (NHs)...
February 2, 2018: Journal of the American Medical Directors Association
Tobias Röck, Karl Ulrich Bartz-Schmidt, Daniel Röck
RATIONALE: Amniotic membrane transplantation (AMT) has been performed therapeutically in humans for over 100 years. In recent 2 decades AMTs have been used increasingly and successfully to treat various types of ophthalmic indications. PATIENT CONCERNS: An 83-year-old man was referred to our eye hospital with a refractory neurotrophic deep corneal ulcer of the left eye. DIAGNOSES: The best-corrected visual acuity of the left eye was 0.5 (0...
December 2017: Medicine (Baltimore)
Dirk Weihrauch, Garett Joseph, Patrick Allen
Invertebrates employ a variety of ammonia excretion strategies to facilitate their survival in diverse aquatic environments, including freshwater, seawater and the water film surrounding soil particles. Various environmental properties set innate challenges for an organism's ammonia excretory capacity. These include the availability of NaCl and the respective ion-permeability of the organism's transport epithelia, and the buffering capacity of their immediate surrounding medium. To this end, some transporters seem to be conserved in the excretory process...
January 29, 2018: Journal of Experimental Biology
Sneha Paul, Anunay Samanta
G-Quadruplex DNA has been a recent target for the anti-cancer agents and its binding interactions with small molecules, often used as anti-cancer drugs, have become an important area of research. Considering that psoralens have long been studied in the context of duplex DNA, but very little is known about its potential as a G-Quadruplex binder and its excited state interaction with the latter has not been explored, we have studied herein the binding of a planar water soluble psoralen derivative, 4'-aminomethyl-4,5',8-trimethyl psoralen (AMT), with the 22-mer human telomeric G-quadruplex forming sequence, AGGG(TTAGGG)3, labeled here as (hTel22), and investigate the consequences of photo-excitation of AMT by calorimetric and spectroscopic techniques...
January 27, 2018: Journal of Physical Chemistry. B
Hua-Tao Xie, Ying-Ying Zhang, Dong-Ling Jiang, Jun Wu, Jia-Song Wang, Ming-Chang Zhang
To evaluate the outcome of amniotic membrane transplantation (AMT) after tumor excision followed by topical interferon alfa-2b (IFNα2b) drops for primary ocular surface squamous neoplasia (OSSN). Twelve eyes of 12 patients with a mean age of 66±10y were included. The average follow-up was 23±10mo. All 12 patients had limbal involvement. Smooth ocular surface and transparent cornea were achieved in all cases. No sign of inflammation, neovascularization, symblepharon or recurrence was noted at the last follow-up...
2018: International Journal of Ophthalmology
Abdus Samad Ansari, Brittany B Dennis, Dilip Shah, Winfred Baah
BACKGROUND: Pneumocephalus, illustrated by air in the cranial vault is relatively infrequent and generally associated with neurosurgery, trauma, meningitis and barotrauma. However cases of spontaneous non-traumatic pneumocephalus remain rare. While the relationship between continuous positive airway pressure (CPAP) and atraumatic pneumocephalus has been previously reported, to our knowledge the rare presentation associated with sinus wall osteomyelitis has never been described. We summarize here the case of a 67-year-old woman's acute presentation of Streptococcus salvarius infection after a sudden drop in her consciousness...
January 18, 2018: BMC Emergency Medicine
Shruti Aggarwal, Christopher T Shah, Maria Kirzhner
To describe a novel technique utilizing an amniotic membrane graft (AMT) to create the mucocutaneous portion of the lower eyelid margin in a modified Hughes eyelid reconstruction for secondary revision or prevention of a hyperemic, hypertrophic conjunctival margin with excessive discharge. This was a retrospective, non-comparative interventional study. Thirty consecutive patients who underwent a modified Hughes reconstruction were included. The first step of the reconstruction was performed in a standard fashion using a tarsoconjunctival flap from the ipsilateral upper eyelid...
January 15, 2018: Orbit
Efthymios Iliopoulos, Sohail Yousaf, Hazel Watters, Arshad Khaleel
Neck of femur (NOF) fractures in elderly patients are the most frequent condition which an orthopaedic surgeon confronts nowadays. The incidence of these fractures is increasing as the population continues to age. These patients absorb the majority of the resources in the hospitals, as their healthcare demands are increased. This study included all patients who were admitted to our hospital between January and October 2015 following a neck of femur fracture. A total of 336 patients were included (72.3% female)...
December 2017: Journal of Perioperative Practice
Tobias Pflüger, Camila F Hernández, Philipp Lewe, Fabian Frank, Haydyn Mertens, Dmitri Svergun, Manfred W Baumstark, Vladimir Y Lunin, Mike S M Jetten, Susana L A Andrade
Sensing and uptake of external ammonium is essential for anaerobic ammonium-oxidizing (anammox) bacteria, and is typically the domain of the ubiquitous Amt/Rh ammonium transporters. Here, we report on the structure and function of an ammonium sensor/transducer from the anammox bacterium "Candidatus Kuenenia stuttgartiensis" that combines a membrane-integral ammonium transporter domain with a fused histidine kinase. It contains a high-affinity ammonium binding site not present in assimilatory Amt proteins. The levels of phosphorylated histidine in the kinase are coupled to the presence of ammonium, as conformational changes during signal recognition by the Amt module are transduced internally to modulate the kinase activity...
January 11, 2018: Nature Communications
Yiming Lin, Zhenzhu Zheng, Wenjia Sun, Qingliu Fu
BACKGROUND: Non-ketotic hyperglycinemia (NKH) is a rare, devastating autosomal recessive disorder of glycine metabolism with a very poor prognosis. Currently, few studies have reported genetic profiling of Chinese NKH patients. This study aimed to identify the genetic mutations in a Chinese family with NKH. METHODS: A Chinese family of Han ethnicity, with three siblings with NKH was studied. Sanger sequencing and multiplex ligation-dependent probe amplification combined with SYBR green real-time quantitative PCR was used to identify potential mutations in the GLDC, AMT and GCSH genes...
January 5, 2018: BMC Medical Genetics
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