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https://www.readbyqxmd.com/read/28638330/flat-vs-expressive-storytelling-young-children-s-learning-and-retention-of-a-social-robot-s-narrative
#1
Jacqueline M Kory Westlund, Sooyeon Jeong, Hae W Park, Samuel Ronfard, Aradhana Adhikari, Paul L Harris, David DeSteno, Cynthia L Breazeal
Prior research with preschool children has established that dialogic or active book reading is an effective method for expanding young children's vocabulary. In this exploratory study, we asked whether similar benefits are observed when a robot engages in dialogic reading with preschoolers. Given the established effectiveness of active reading, we also asked whether this effectiveness was critically dependent on the expressive characteristics of the robot. For approximately half the children, the robot's active reading was expressive; the robot's voice included a wide range of intonation and emotion (Expressive)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28636413/tea-consumption-is-associated-with-cognitive-impairment-in-older-chinese-adults
#2
Ying-Jie Gu, Chun-Hong He, Su Li, Shu-Yi Zhang, Sheng-Yu Duan, Hong-Peng Sun, Yue-Ping Shen, Yong Xu, Jie-Yun Yin, Chen-Wei Pan
OBJECTIVE: To explore the association between tea consumption and cognitive impairment (CoI). METHODS: 4579 adults (≥60 years) from the Weitang Geratric Diseases Study were assessed for characteristics of tea consumption and cognitive function by administering questionnaires and the Abbreviated Mental Test (AMT), respectively. We divided the subjects into normal cognitive function group (AMT score ≥8) and CoI group (AMT score ≤7).   The association between tea consumption and risk of CoI was determined by logistic regression models...
June 21, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28634154/improving-consensus-scoring-of-crowdsourced-data-using-the-rasch-model-development-and-refinement-of-a-diagnostic-instrument
#3
Christopher John Brady, Lucy Iluka Mudie, Xueyang Wang, Eliseo Guallar, David Steven Friedman
BACKGROUND: Diabetic retinopathy (DR) is a leading cause of vision loss in working age individuals worldwide. While screening is effective and cost effective, it remains underutilized, and novel methods are needed to increase detection of DR. This clinical validation study compared diagnostic gradings of retinal fundus photographs provided by volunteers on the Amazon Mechanical Turk (AMT) crowdsourcing marketplace with expert-provided gold-standard grading and explored whether determination of the consensus of crowdsourced classifications could be improved beyond a simple majority vote (MV) using regression methods...
June 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28615805/free-anteromedial-thigh-perforator-flap-complementing-and-completing-the-anterolateral-thigh-flap
#4
Dushyant Jaiswal, Amol Ghalme, Prabha Yadav, Vinaykant Shankhdhar, Akshay Deshpande
OBJECTIVE: Theobjective of this study was to determine the indications, utility, advantages and surgical approach for the anteromedial thigh (AMT) flap. MATERIALS AND METHODS: We reviewed the records of the patients in whom the AMT flap was used for head and neck reconstruction. We use an anterior approach to harvest the anterolateral thigh (ALT) flap with a non-committal straight line incision. This preserves both ALT and AMT flap territories intact, and further decision is based on the intraoperative anatomy of perforator and pedicle...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28589659/validity-and-reliability-of-abbreviated-mental-test-score-amts-among-older-iranian
#5
Mahshid Foroughan, Lars-Olof Wahlund, Zahra Jafari, Mehdi Rahgozar, Ida G Farahani, Vahid Rashedi
BACKGROUND: Cognitive impairment is common among older people and is associated with increased morbidity and mortality. The main aim of this study was to evaluate the validity of the Persian version of the Abbreviated Mental Test Score (AMTS) as a screening tool for dementia. METHODS: Data were obtained from a cross-sectional study. One hundred and one older adults who were members of Iranian Alzheimer Association and 101 of their siblings were entered into this study by convenient sampling...
June 6, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28586778/autobiographical-memory-in-bipolar-disorder-and-its-link-to-neuropsychological-functioning
#6
Esther Quinlivan, Mattea Dallacker, Babette Renneberg, Elisa Strasser, Jana Fiebig, Thomas J Stamm
OBJECTIVE: The aim of this study was to examine the specificity of autobiographical memory (AM) in bipolar disorder (BD) and to investigate the association between AM and neuropsychological functions. METHOD: Twenty bipolar patients and 22 matched healthy controls (HCs) were included in this study. AM was assessed with an extended version of the Autobiographical Memory Test (AMT) including rejection cue words. A neuropsychological test battery was used to examine verbal memory, executive functions, and attention...
June 7, 2017: Psychopathology
https://www.readbyqxmd.com/read/28577267/cognitive-training-in-alzheimer-s-disease-a-controlled-randomized-study
#7
A R Giovagnoli, V Manfredi, A Parente, L Schifano, S Oliveri, G Avanzini
This controlled randomized single-blind study evaluated the effects of cognitive training (CT), compared to active music therapy (AMT) and neuroeducation (NE), on initiative in patients with mild to moderate Alzheimer's disease (AD). Secondarily, we explored the effects of CT on episodic memory, mood, and social relationships. Thirty-nine AD patients were randomly assigned to CT, AMT, or NE. Each treatment lasted 3 months. Before, at the end, and 3 months after treatment, neuropsychological tests and self-rated scales assessed initiative, episodic memory, depression, anxiety, and social relationships...
June 2, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28530213/-the-model-of-perioperative-risk-assessment-in-elderly-patients-interim-analysis
#8
Izabela Grabowska, Lucyna Ścisło, Szymon Pietruszka, Elzbieta Walewska, Agata Paszko, Benita Siarkiewicz, Piotr Richter, Andrzej Budzyński, Antoni M Szczepanik
Demographic changes in contemporary society require implementation of proper perioperative care of elderly patients due to an increased risk of perioperative complications in this group. Preoperative assessment of health status identifies risks and enables preventive interventions, improving outcomes of surgical treatment. The Comprehensive Geriatric Assessment contains numerous diagnostic tests and consultations, which is expensive and difficult to use in everyday practice. The development of a simplified model of perioperative assessment of elderly patients will help identifying the group of patients who require further diagnostic workup...
April 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28529635/synthesis-of-5-18-f-fluoro-%C3%AE-methyl-tryptophan-new-trp-based-pet-agents
#9
Benjamin C Giglio, Haiyang Fei, Mengzhe Wang, Hui Wang, Liu He, Huijuan Feng, Zhanhong Wu, Hongjian Lu, Zibo Li
Indoleamine 2,3-dioxygenase (IDO1) plays a special role in the biology of various cancer types, because it breaks down the essential amino acid tryptophan for immune cell activation. Upregulation of IDO1 significantly correlates with the number of various T cell types in tumor tissues in melanoma and other cancers, suggesting that IDO expression is linked with effective and ineffective ('exhausted') immune response in cancer. Based on the reported IDO inhibitors (α-Methylated and indole-N-methylated tryptophan (Trp)), here we report the synthesis of potential IDO1 imaging agents through direct introduction of (18)F into the tryptophan aromatic ring...
2017: Theranostics
https://www.readbyqxmd.com/read/28515601/quality-indicators-compliance-survey-in-indian-intensive-care-units
#10
Munta Kartik, Palepu B N Gopal, Rahul Amte
CONTEXT: The quality of health care and outcomes of Intensive Care Unit (ICU) have been a major subject of discussion in the past decade. Quality indicators in ICUs maintain an order of uniformity and standard care of delivery across ICUs. AIMS: In this study, we tried to analyze the percentage compliance of quality indicators in ICU across our country. METHODS: Four hundred complete questionnaire forms were collected in two stages by means of conducting a survey and through email responses to the survey questionnaire...
April 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28510495/fatigue-in-younger-and-older-drivers-effectiveness-of-an-alertness-maintaining-task
#11
Woojin Song, Fu L Woon, Alice Doong, Carol Persad, Louis Tijerina, Pooja Pandit, Carol Cline, Bruno Giordani
OBJECTIVE: The aim of this study was to examine the effects of an alertness maintaining task (AMT) in older, fatigued drivers. BACKGROUND: Fatigue during driving increases crash risk, and previous research suggests that alertness and driving in younger adults may be improved using a secondary AMT during boring, fatigue-eliciting drives. However, the potential impact of an AMT on driving has not been investigated in older drivers whose ability to complete dual tasks has been shown to decline and therefore may be negatively affected with an AMT in driving...
May 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28499834/n-stearoyltyrosine-protects-primary-cortical-neurons-against-oxygen-glucose-deprivation-induced-apoptosis-through-inhibiting-anandamide-inactivation-system
#12
Heng-Jing Cui, Sha Liu, Rui Yang, Guo-Hui Fu, Yang Lu
N-stearoylthrosine (NST), a synthesized anandamide (AEA) analogue, plays a neuroprotective role in neurodegenerative diseases and cerebrovascular diseases. Several studies have demonstrated that the endocannabinoids systems (ECS) are involved in the neuroprotective effects against cerebral ischemic injury. Oxygen-glucose deprivation (OGD)-induced neuronal injury elevated the levels of endocannabinoids and activated ECS. This research was conducted to investigate the neuroprotective effect of NST against OGD-induced neuronal injury in cultured primary cortical neurons and the potential mechanism involved...
May 9, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28492281/c-elegans-chromosomes-connect-to-centrosomes-by-anchoring-into-the-spindle-network
#13
Stefanie Redemann, Johannes Baumgart, Norbert Lindow, Michael Shelley, Ehssan Nazockdast, Andrea Kratz, Steffen Prohaska, Jan Brugués, Sebastian Fürthauer, Thomas Müller-Reichert
The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the first large-scale serial electron tomography of whole mitotic spindles in early C. elegans embryos with live-cell imaging to reconstruct all microtubules in 3D and identify their plus- and minus-ends. We classify them as kinetochore (KMTs), spindle (SMTs) or astral microtubules (AMTs) according to their positions, and quantify distinct properties of each class. While our light microscopy and mutant studies show that microtubules are nucleated from the centrosomes, we find only a few KMTs directly connected to the centrosomes...
May 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28490757/transcriptome-and-metabolite-analysis-identifies-nitrogen-utilization-genes-in-tea-plant-camellia-sinensis
#14
Wei Li, Fen Xiang, Micai Zhong, Lingyun Zhou, Hongyan Liu, Saijun Li, Xuewen Wang
Applied nitrogen (N) fertilizer significantly increases the leaf yield. However, most N is not utilized by the plant, negatively impacting the environment. To date, little is known regarding N utilization genes and mechanisms in the leaf production. To understand this, we investigated transcriptomes using RNA-seq and amino acid levels with N treatment in tea (Camellia sinensis), the most popular beverage crop. We identified 196 and 29 common differentially expressed genes in roots and leaves, respectively, in response to ammonium in two tea varieties...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28482134/adipocyte-myofibroblast-transition-as-a-possible-pathophysiological-step-in-androgenetic-alopecia
#15
LETTER
Ilja L Kruglikov, Philipp E Scherer
Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
June 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28473764/paired-associative-stimulation-targeting-the-tibialis-anterior-muscle-using-either-mono-or-biphasic-transcranial-magnetic-stimulation
#16
Natalie Mrachacz-Kersting, Andrew J T Stevenson
Paired associative stimulation (PAS) protocols induce plastic changes within the motor cortex. The objectives of this study were to investigate PAS effects targeting the tibialis anterior (TA) muscle using a biphasic transcranial magnetic stimulation (TMS) pulse form and, to determine whether a reduced intensity of this pulse would lead to significant changes as has been reported for hand muscles using a monophasic TMS pulse. Three interventions were investigated: (1) suprathreshold PAbi-PAS (n = 11); (2) suprathreshold PAmono-PAS (n = 11) where PAS was applied using a biphasic or monophasic pulse form at 120% resting motor threshold (RMT); (3) subthreshold PAbi-PAS (n = 10) where PAS was applied as for (1) at 95% active motor threshold (AMT)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28472731/online-test-purchased-new-psychoactive-substances-in-5-different-european-countries-a-snapshot-study-of-chemical-composition-and-price
#17
Tibor Markus Brunt, Amanda Marie Atkinson, Thomas Nefau, Magali Martinez, Emmanuel Lahaie, Artur Malzcewski, Martin Pazitny, Vendula Belackova, Simon D Brandt
BACKGROUND: New psychoactive substances (NPS) are on offer worldwide online, in order to shed light on the purity and price of these substances in the European Union, a research collaboration was set up involving France, United Kingdom (UK), the Netherlands, Czech Republic and Poland. METHODS: Per country, around 10 different NPS were test purchased from different webshops. Then, chemical analysis of NPS was done with according reference standards to identify and quantify the contents...
May 1, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28470139/reduced-specificity-and-enhanced-subjective-experience-of-future-thinking-in-ageing-the-influence-of-avoidance-and-emotion-regulation-strategies
#18
Sabrina Jumentier, Catherine Barsics, Martial Van der Linden
Future thinking in older adults is characterised by a lack of specificity of imagined events and by an equal or even higher subjective experience, compared to younger adults. We considered whether this lack of specificity stemmed partly from the avoidance of a somewhat disturbing future and then examined the extent to which certain types of emotion-regulation strategies, namely positive reappraisal and positive refocusing, contributed to the subjective experience of future thinking. Middle-aged and older adults completed an adapted version of the AMT, in which temporal distance and cue word valence were manipulated, thus resulting in future conditions assumed to represent varying degrees of discomfort...
May 4, 2017: Memory
https://www.readbyqxmd.com/read/28462797/d-glyceric-aciduria-does-not-cause-nonketotic-hyperglycinemia-a-historic-co-occurrence
#19
Michael A Swanson, Stephanie M Garcia, Elaine Spector, Kathryn Kronquist, Geralyn Creadon-Swindell, Melanie Walter, Ernst Christensen, Johan L K Van Hove, Jörn Oliver Sass
Historically, d-glyceric aciduria was thought to cause an uncharacterized blockage to the glycine cleavage enzyme system (GCS) causing nonketotic hyperglycinemia (NKH) as a secondary phenomenon. This inference was reached based on the clinical and biochemical results from the first d-glyceric aciduria patient reported in 1974. Along with elevated glyceric acid excretion, this patient exhibited severe neurological symptoms of myoclonic epilepsy and absent development, and had elevated glycine levels and decreased glycine cleavage system enzyme activity...
April 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28450179/amniotic-membrane-transplants-in-the-pediatric-population
#20
Mariam S Ahmad, Garett S Frank, Eric M Hink, Alan G Palestine, Darren G Gregory, Emily A McCourt
PURPOSE: To investigate the indications for and results of amniotic membrane transplantation (AMT) for the treatment of ocular disease in pediatric patients at a single institution. METHODS: The medical records of patients <18 years of age who underwent AMT for ocular disease between January 1, 2003, and September 1, 2015, were reviewed retrospectively. Patients were determined to have reached a clinical endpoint if there was resolution of the ocular condition being treated after AMT placement, no additional surgery required for treatment of the ocular condition, and no active disease at most recent follow-up...
April 24, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
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