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Skeletal muscle hypertrophy

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https://www.readbyqxmd.com/read/28926107/fenofibrate-reverses-changes-induced-by-high-fat-diet-on-metabolism-in-mice-muscle-and-visceral-adipocytes
#1
Flávia de Toledo Frias, Karina Cunha E Rocha, Mariana de Mendonça, Gilson Massahiro Murata, Hygor Nunes Araujo, Luís Gustavo Oliveira de Sousa, Érica de Souza, Sandro Massao Hirabara, Nayara de Carvalho Leite, Everardo Magalhães Carneiro, Rui Curi, Leonardo Reis Silveira, Alice Cristina Rodrigues
The effect of fenofibrate on the metabolism of skeletal muscle and visceral white adipose tissue of diet-induced obese (DIO) mice was investigated. C57BL/6J male mice were fed either a control or high-fat diet for eight weeks. Fenofibrate (50 mg/Kg b.w., daily) was administered by oral gavage during the last two weeks of the experimental period. Insulin-stimulated glucose metabolism in soleus muscles, glucose tolerance test, insulin tolerance test, indirect calorimetry, lipolysis of visceral white adipose tissue, expression of miR-103-3p in adipose tissue and miR-1a, miR-133a/b, miR-206, let7b-5p, miR-23b-3p, miR-29-3p, miR-143-3p in soleus muscle, genes related to glucose and fatty acid metabolism in adipose tissue and soleus muscle, and proteins (phospho-AMPKα2, Pgc1α, Cpt1b), intramuscular lipid staining, and activities of fatty acid oxidation enzymes in skeletal muscle were investigated...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28917653/human-il6-stimulates-bovine-satellite-cell-proliferation-through-a-signal-transducer-and-activator-of-transcription-3-stat3-dependent-mechanism
#2
A M Brandt, J M Kania, B M Reinholt, S E Johnson
Bovine satellite cell (bSC) myogenesis and skeletal muscle hypertrophy occur through the orchestrated actions of multiple autocrine and paracrine growth factors. Intimate to the bSC niche is IL6, a dual-purpose cytokine with proinflammatory and mitogenic properties. The objective of the experiment was to examine the effects of IL6 on proliferation and differentiation of bSC in vitro. Treatment of primary bSC cultures with recombinant bovine IL6 (bIL6) failed to alter myogenesis owing to the absence of intracellular signal transduction...
August 31, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28904016/lncrna-ak017368-promotes-proliferation-and-suppresses-differentiation-of-myoblasts-in-skeletal-muscle-development-by-attenuating-the-function-of-mir-30c
#3
Tingting Liang, Bo Zhou, Lei Shi, Han Wang, Qingpo Chu, Feilong Xu, Yuan Li, Ruonan Chen, Chunyan Shen, Allan P Schinckel
Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in biologic and pathologic processes, including myogenesis. We found that lncRNA AK017368 is highly expressed in skeletal muscle cells. Functional analyses showed that overexpression of AK017368 promoted proliferation and restrained differentiation of myoblasts; whereas inhibition of AK017368 had completely opposite effects in vitro In mice, knockdown of AK017368 promoted muscle hypertrophy in vivo RNA molecules of AK017368 acted mechanistically as competing endogenous RNAs to target micro-RNA (miR)-30c, which was supported by the results of bioinformatics analyses and dual-luciferase reporter assays...
September 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28900124/using-crispr-cas9-mediated-gene-editing-to-further-explore-growth-and-trade-off-effects-in-myostatin-mutated-f4-medaka-oryzias-latipes
#4
Ying-Chun Yeh, Masato Kinoshita, Tze Hann Ng, Yu-Hsuan Chang, Shun Maekawa, Yi-An Chiang, Takashi Aoki, Han-Ching Wang
Myostatin (MSTN) suppresses skeletal muscle development and growth in mammals, but its role in fish is less well understood. Here we used CRISPR/Cas9 to mutate the MSTN gene in medaka (Oryzias latipes) and evaluate subsequent growth performance. We produced mutant F0 fish that carried different frameshifts in the OlMSTN coding sequence and confirmed the heritability of the mutant genotypes to the F1 generation. Two F1 fish with the same heterozygous frame-shifted genomic mutations (a 22 bp insertion in one allele; a 32 bp insertion in the other) were then crossbred to produce subsequent generations (F2~F5)...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878590/enzymatically-modified-isoquercitrin-supplementation-intensifies-plantaris-muscle-fiber-hypertrophy-in-functionally-overloaded-mice
#5
Akiko Kohara, Masanao Machida, Yuko Setoguchi, Ryouichi Ito, Masanori Sugitani, Hiroko Maruki-Uchida, Hiroyuki Inagaki, Tatsuhiko Ito, Naomi Omi, Tohru Takemasa
BACKGROUND: Enzymatically modified isoquercitrin (EMIQ) is produced from rutin using enzymatic hydrolysis followed by treatment with glycosyltransferase in the presence of dextrin to add glucose residues. EMIQ is absorbed in the same way as quercetin, a powerful antioxidant reported to prevent disused muscle atrophy by targeting mitochondria and to have ergogenic effects. The present study investigated the effect of EMIQ on skeletal muscle hypertrophy induced by functional overload. METHODS: In Study 1, 6-week-old ICR male mice were divided into 4 groups: sham-operated control, sham-operated EMIQ, overload-operated control, and overload-operated EMIQ groups...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28869034/plasticity-and-function-of-human-skeletal-muscle-in-relation-to-disuse-and-rehabilitation-influence-of-ageing-and-surgery
#6
Charlotte Suetta
In order to study the influence of disuse and aging on skeletal muscle homeostasis, different human models were employed. Effects of chronic disuse were investigated in elderly patients suffering from uni-lateral hip-osteoarthritis, whereas the effect of short-term disuse (4 and 14 days of unilateral lower limb immobilisation) was assessed in healthy young and old individuals. In summary, chronic muscle disuse in the elderly was associated with marked quantitative as well as qualitative neuromuscular impairments...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28862673/igf-1-attenuates-hypoxia-induced-atrophy-but-inhibits-myoglobin-expression-in-c2c12-skeletal-muscle-myotubes
#7
Eva L Peters, Sandra M van der Linde, Ilse S P Vogel, Mohammad Haroon, Carla Offringa, Gerard M J de Wit, Pieter Koolwijk, Willem J van der Laarse, Richard T Jaspers
Chronic hypoxia is associated with muscle wasting and decreased oxidative capacity. By contrast, training under hypoxia may enhance hypertrophy and increase oxidative capacity as well as oxygen transport to the mitochondria, by increasing myoglobin (Mb) expression. The latter may be a feasible strategy to prevent atrophy under hypoxia and enhance an eventual hypertrophic response to anabolic stimulation. Mb expression may be further enhanced by lipid supplementation. We investigated individual and combined effects of hypoxia, insulin-like growth factor (IGF)-1 and lipids, in mouse skeletal muscle C2C12 myotubes...
September 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28861930/electrical-pulse-stimulation-an-in-vitro-exercise-model-for-the-induction-of-human-skeletal-muscle-cell-hypertrophy-a-proof-of-concept-study
#8
Janelle Tarum, Mattias Folkesson, Philip J Atherton, Fawzi Kadi
Electrical Pulse Stimulation (EPS) of muscle cells has previously been used as an in vitro exercise model. The present study aims to establish an EPS protocol promoting the hypertrophy of human muscle cells, which represents a major physiological endpoint to resistance exercise in humans. We hypothesized that adding a resting period after EPS would be critical for the occurrence of the morphological change. Myoblasts obtained from human muscle biopsies (n = 5) were differentiated into multinucleated myotubes and exposed to 8 h EPS consisting of 2 ms pulses at 12 V with a frequency of 1 Hz...
August 31, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28855249/lncrna-chronos-is-an-aging-induced-inhibitor-of-muscle-hypertrophy
#9
Ronald L Neppl, Chia-Ling Wu, Kenneth Walsh
Skeletal muscle exhibits remarkable plasticity in its ability to modulate its mass in response to the physiologic changes associated with functional use, systemic disease, and aging. Although a gradual loss of muscle mass normally occurs with advancing age, its increasingly rapid progression results in sarcopenia in a subset of individuals. The identities of muscle-enriched, long noncoding RNAs that regulate this process are unknown. Here, we identify a long noncoding RNA, named Chronos, whose expression in muscle is positively regulated with advancing age and negatively regulated during Akt1-mediated growth...
August 30, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28846563/temporal-response-of-angiogenesis-and-hypertrophy-to-resistance-training-in-young-men
#10
Tanya M Holloway, Tim Snijders, Janneau van Kranenburg, Luc Jc van Loon, Lex B Verdijk
While endurance exercise training promotes angiogenesis and improves metabolic health, the effect of resistance training on this process is less well defined. We hypothesised that capillarization would increase proportionally, and concurrently, with muscle fiber hypertrophy in response to resistance training in young men. METHODS: In this double blind, randomized control trial, 36 males (22 ± 1 y) were randomized to placebo or protein supplementation, and participated in 12-wk of resistance training...
August 25, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28843510/an-alternative-model-for-studying-age-associated-metabolic-complications-senescence-accelerated-mouse-prone-8
#11
Hung-Wen Liu, Yin-Ching Chan, Chu-Chun Wei, Yun-An Chen, Ming-Fu Wang, Sue-Joan Chang
Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. The short-lived strain SAMP8 and two long-lived strains SAM resistant 1 (SAMR1) mice and C57BL/6 mice at 12 (young) and 40weeks old (old) were used in the present study. Glucose tolerance test, histology and signaling pathways involved in lipid metabolism in adipose tissue and liver and key components of insulin signaling pathway in the skeletal muscle were determined in these three strains...
August 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28841254/functional-capacity-in-a-rat-model-of-heart-failure-impact-of-myocardial-infarction-size
#12
Vítor Scotta Hentschke, Lucas Capalonga, Douglas Dalcin Rossato, Júlia Luíza Perini, Jadson Pereira Alves, Edson Quagliotto, Giuseppe Potrick Stefani, Marlus Karsten, Mauro Pontes, Pedro Dal Lago
Oxygen uptake (VO2 ) and exercise tolerance in rats classified by myocardial infarction (MI) size are underexplored. The aim of this study was to evaluate VO2 /carbon dioxide production (VCO2 ) and exercise tolerance in rats that have undergone MI. Fourteen weeks after MI or sham surgery, rats underwent an integrated approach to left ventricular function and VO2 /VCO2 , exercise tolerance and skeletal muscle weight evaluation. Based on MI size determination, rats were assigned to sham operated controls (Sham, n = 12), small myocardial infarction (SMI, n = 8), and large myocardial infarction (LMI, n = 5) groups...
August 25, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28841247/heart-bound-adiponectin-not-serum-adiponectin-inversely-correlates-with-cardiac-hypertrophy-in-stroke-prone-spontaneously-hypertensive-rats
#13
Takao Inoue, Kumiko Takemori, Nobuyuki Mizuguchi, Masatomo Kimura, Takaaki Chikugo, Man Hagiyama, Azusa Yoneshige, Tatsufumi Mori, Osamu Maenishi, Takashi Kometani, Tatsuki Itoh, Takao Satou, Akihiko Ito
The inverse correlation between circulating adiponectin concentration and hypertension or cardiac hypertrophy is still controversial. In addition to circulating adiponectin, adiponectin is also bound to tissues such as the heart and skeletal muscle. In this study, we investigated the relationship of serum adiponectin and heart-bound adiponectin to hypertension and cardiac hypertrophy. Four types of hypertensive rats presenting different blood pressure levels were used at different ages: normotensive Wistar-Kyoto rats (WKY); two sub-strains (strains C and B2, having low and high blood pressure, respectively) of spontaneously hypertensive rats (SHR); and stroke-prone SHR (SHRSP)...
August 25, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28838540/microrna-dysregulation-in-aging-and-pathologies-of-the-skeletal-muscle
#14
Rachel McCormick, Katarzyna Goljanek-Whysall
Skeletal muscle is one of the biggest organs of the body with important mechanistic and metabolic functions. Muscle homeostasis is controlled by environmental, genetic, and epigenetic factors. Indeed, MiRNAs, small noncoding RNAs robust regulators of gene expression, have and have been shown to regulate muscle homeostasis on several levels: through controlling myogenesis, muscle growth (hypertrophy) and atrophy, as well as interactions of muscle with other tissues. Given the large number of MiRNA target genes and the important role of MiRNAs in most physiological processes and various diseases, MiRNAs may have an enormous potential as therapeutic targets against numerous disorders, including pathologies of muscle...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28811636/mussel-inspired-polynorepinephrine-functionalized-electrospun-polycaprolactone-microfibers-for-muscle-regeneration
#15
Ying Liu, Guoqiang Zhou, Zhu Liu, Mengyu Guo, Xiumei Jiang, Mehmet Berat Taskin, Zhongyang Zhang, Jing Liu, Jinglong Tang, Ru Bai, Flemming Besenbacher, Menglin Chen, Chunying Chen
Electrospun scaffolds with excellent mechanical properties, high specific surface area and a commendable porous network are widely used in tissue engineering. Improving the hydrophilicity and cell adhesion of hydrophobic substrates is the key point to enhance the effectiveness of electrospun scaffolds. In this study, polycaprolactone (PCL) fibrous membranes with appropriate diameter were selected and coated by mussel-inspired poly norepinephrine (pNE). And norepinephrine is a catecholamine functioning as a hormone and neurotransmitter in the human brain...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811294/dihydrocapsiate-improved-age-associated-impairments-in-mice-by-increasing-energy-expenditure
#16
Kana Ohyama, Katsuya Suzuki
Metabolic dysfunction is associated with aging and results in age-associated chronic diseases, including type 2 diabetes mellitus, cardiovascular disease, and stroke. Hence, there has been a focus on increasing energy expenditure in aged populations to protect them from age-associated diseases. Dihydrocapsiate (DCT) is a compound that belongs to the capsinoid family. Capsinoids are capsaicin analogs that are found in non-pungent peppers and increase whole-body energy expenditure. However, their effect on energy expenditure has been reported only in young populations, and to date the effectiveness of DCT in increasing energy expenditure in aged populations has not been investigated...
August 15, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28811140/divergent-effects-of-resistance-training-and-anabolic-steroid-on-the-postsynaptic-region-of-different-skeletal-muscles-of-aged-rats
#17
Walter Krause Neto, Wellington de Assis Silva, Adriano Polican Ciena, Carlos Alberto Anaruma, Eliane Florencio Gama
This study aimed to analyze the effects of resistance training associated with testosterone administration in the neuromuscular junction (NMJ) postsynaptic region of different skeletal muscle types of aged rats. Wistar rats were divided into: SEI - 20-months-old control, SEF - 24-months-old control, T - 20-months-old with testosterone, S - 20-months-old resistance trained and ST - 20-months-old with resistance training associated with testosterone propionate. All groups were submitted to familiarization and maximum load carrying testing (MLCT)...
August 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28810121/comparative-proteomic-and-transcriptomic-analysis-of-follistatin-induced-skeletal-muscle-hypertrophy
#18
Caroline Barbé, Fabrice Bray, Marine Gueugneau, Stéphanie Devassine, Pascale Lause, Caroline Tokarski, Christian Rolando, Jean-Paul Thissen
Skeletal muscle, the most abundant body's tissue, plays vital roles in locomotion and metabolism. Myostatin is a negative regulator of skeletal muscle mass. In addition to increase muscle mass, Myostatin inhibition impacts on muscle contractility and energy metabolism. To decipher the mechanisms of action of the Myostatin inhibitors, we used proteomic and transcriptomic approaches to investigate the changes induced in skeletal muscles of transgenic mice overexpressing Follistatin, a physiological Myostatin inhibitor...
August 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28809625/microstructural-changes-of-tensor-fasciae-latae-and-gluteus-medius-muscles-following-total-hip-arthroplasty-a-prospective-trial
#19
M Pumberger, P VON Roth, B Preininger, M Mueller, C Perka, T Winkler
PURPOSE OF THE STUDY Although total hip arthroplasty (THA) is one of the most successful orthopedic operations, the soft tissue trauma towards the periarticular musculature during surgical approaches remains a critical concern. However, the actual microstructural proof of muscle trauma on the level of the myofiber due to the surgical approach has never been claimed. MATERIAL AND METHODS Patients undergoing THA were prospectively enrolled and either operated by a direct lateral (DL) or a anterolateral minimally invasive approach (ALMI)...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28782600/mir-18a-induces-myotubes-atrophy-by-down-regulating-igfi
#20
Chuncheng Liu, Meng Wang, Min Chen, Kuo Zhang, Lijie Gu, Qiuyan Li, Zhengquan Yu, Ning Li, Qingyong Meng
Muscle atrophy occurs when there is a net loss of muscle mass, leading to a change in the balance between protein synthesis and protein degradation. Igf1 is important for protein synthesis in muscle cells and can induce local skeletal muscle hypertrophy and attenuate age-related skeletal muscle atrophy via the PI3K/Akt pathway in mice, consequently restoring and improving muscle mass and strength. In this study, we show that miR-18a expression is down-regulated during C2C12 myoblast differentiation and mouse tibialis anterior muscle postnatal development...
August 4, 2017: International Journal of Biochemistry & Cell Biology
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