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https://www.readbyqxmd.com/read/29924454/prognostic-impact-of-doublecortin-like-kinase-1-expression-in-locally-advanced-rectal-cancer-treated-with-preoperative-chemoradiotherapy
#1
Yuzo Harada, Shinsuke Kazama, Teppei Morikawa, Shigenobu Emoto, Koji Murono, Manabu Kaneko, Kazuhito Sasaki, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hiroaki Nozawa, Soichiro Ishihara, Toshiaki Watanabe
Preoperative chemoradiotherapy (CRT) is a standard therapy for locally advanced rectal cancer; however, the response varies depending on cases. Therefore, CRT-response predictors need to be elucidated. Cancer stem cells (CSCs), comprising a small part of tumors, are associated with tumor progression and recurrence due to their self-renewal and proliferation abilities. Doublecortin-like kinase 1 (DCLK1) is one of the several putative CSC markers; however, the clinical impact of its expression in rectal cancer has not been evaluated...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29923484/3d-mri-segmentation-and-3d-circumferential-resection-margin-evaluation-for-a-standard-rectal-cancer-assessment
#2
L Lorenzon, F Bini, M Quatrale, A Biondi, R Persiani, M Di Pietropaolo, F Landolfi, E Iannicelli, F Marinozzi, G Balducci, D D'Ugo
AIM: Recent studies focused on rectal cancer suggested that a 3D imaging segmentation obtained from MRI data could contribute in the definition of the circumferential resection margin (CRM) and in the assessment of the tumor regression following neo-adjuvant treatments. Here, we propose a method for defining and visualizing the circumferential margins using 3D MRI segmentation; this methodology was tested in a clinical study comparing 3D CRM assessment vs standard MRI imaging. PATIENTS AND METHODS: MRI scans performed before neo-adjuvant treatments were selected and reviewed...
May 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29923482/comparison-of-outcomes-following-intersphincteric-resection-vs-low-anterior-resection-for-low-rectal-cancer-a-systematic-review
#3
REVIEW
P Ursi, A Santoro, A Gemini, A Arezzo, D Pironi, C Renzi, R Cirocchi, F M Di Matteo, A Maturo, V D'Andrea, J Sagar
BACKGROUND: Low Rectal Anterior Resection (LAR) is challenging when anal canal mucosa and/or internal sphincter are involved by very low tumors. In these cases, Intersphincteric resection (ISR) with the removal of the internal sphincter is designed to increase the distal margin of resection, thus preserving the external sphincter and pubo-rectalis muscle complex. Aim is to compare results after ISR with those of LAR, including subgroup analysis of open, laparoscopic and robotic ISR. METHODS: Studies published from January 1991 to January 2017 describing ISR and comparing results with LAR in adults were included irrespective of the technique...
May 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29922520/magnetic-resonance-guided-inter-fraction-monitoring-opens-doors-to-delivering-safer-reirradiation-an-illustrative-case-report-and-discussion
#4
Rebecca Levin-Epstein, Minsong Cao, Percy Lee, Michael L Steinberg, James Lamb, Ann C Raldow
Locoregional recurrence in the pelvis after definitive treatment for rectal cancer can lead to significant morbidity. Furthermore, the toxicity associated with reirradiation may also negatively impact the quality of life and even survival. Here we present the case of a 39-year-old male with locoregionally recurrent rectal cancer in a left pelvic sidewall lymph node, treated with stereotactic magnetic resonance (MR)-guided ablative radiotherapy after previously receiving long-course chemoradiation that had already exceeded ideal bowel dose constraints...
April 14, 2018: Curēus
https://www.readbyqxmd.com/read/29921296/acquired-factor-xii-deficiency-following-transanal-excision-of-rectal-lesion-by-transanal-minimally-invasive-surgery-tamis-a-case-report-and-literature-review
#5
Maria Rita Cozzi, Andrea Lauretta, Roberto Vettori, Agostino Steffan
BACKGROUND: Local excision (LE) is currently one of the most effective methods used in cases of large benign polyps, not suitable for endoscopic treatment, or early-stage neoplasms. LE is also alternative to anterior rectal resection in selected patients suffering from major comorbidities and limits for major abdominal procedure. Furthermore, LE results in less pain, reduced impact on bowel function, shorter duration of hospital stay, and lower rates of morbidity, mortality and stoma creation...
June 19, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29921291/urethra-sparing-stereotactic-body-radiotherapy-for-prostate-cancer-how-much-can-the-rectal-wall-dose-be-reduced-with-or-without-an-endorectal-balloon
#6
Angèle Dubouloz, Michel Rouzaud, Lev Tsvang, Wilko Verbakel, Mikko Björkqvist, Nadine Linthout, Joana Lencart, Juan María Pérez-Moreno, Zeynep Ozen, Lluís Escude, Thomas Zilli, Raymond Miralbell
BACKGROUND: This is a dosimetric comparative study intended to establish appropriate low-to-intermediate dose-constraints for the rectal wall (Rwall ) in the context of a randomized phase-II trial on urethra-sparing stereotactic body radiotherapy (SBRT) for prostate cancer. The effect of plan optimization on low-to-intermediate Rwall dose and the potential benefit of an endorectal balloon (ERB) are investigated. METHODS: Ten prostate cancer patients, simulated with and without an ERB, were planned to receive 36...
June 19, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29920909/a-qualitative-study-of-the-development-of-a-multidisciplinary-case-conference-review-methodology-to-reduce-involved-margins-in-pelvic-exenteration-surgery-for-recurrent-rectal-cancer
#7
Gabrielle H van Ramshorst, Sarah 'o Shannassy, Wendy E Brown, James G Kench, Michael J Solomon
AIM: Pelvic exenteration surgery remains the only curative option for recurrent rectal cancer. Microscopically involved surgical margins (R1) are associated with a higher risk of local recurrence and decreased survival. Our study aimed to develop a post hoc multidisciplinary case conference review and investigate its potential for identifying areas for improvement. METHOD: Patients who underwent pelvic exenteration surgery for recurrent rectal cancer with R1 resections at a tertiary referral center between April 2014- January 2016 were retrospectively reviewed from a prospectively maintained database...
June 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29920380/transvaginal-treatment-of-anterior-and-apical-genital-prolapses-using-an-ultra-lightweight-mesh-restorelle%C3%A2-direct-fixtm-a-retrospective-study-on-feasibility-and-morbidity
#8
Philippe Ferry, Pauline Bertherat, Anne Gauthier, Richard Villet, Francesco Del Piano, David Hamid, Hervé Fernandez, Pierre-Louis Broux, Delphine Salet-Lizée, Etienne Vincens, Pierre Ntshaykolo, Philippe Debodinance, Philippe Pocholle, Yannick Thirouard, Renaud de Tayrac
Vaginal mesh safety information is limited, especially concerning single incision techniques using ultra lightweight meshes for the treatment of anterior pelvic organ prolapse (POP). Objective To determine the intraoperative and postoperative complication rates after anterior POP repair involving an ultralight mesh (19kg/m2 ): Restorelle® Direct Fix™. Methods A case series of 218 consecutive patients, operated on between January 2013 and December 2016 in ten tertiary and secondary care centres, was retrospectively analysed...
June 16, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29920143/molecular-characterization-of-carbapenem-resistant-acinetobacter-baumannii-in-the-intensive-care-unit-of-uruguay-s-university-hospital-identifies-the-first-rmtc-gene-in-the-species
#9
Inés Bado, Romina Papa-Ezdra, Jose F Delgado-Blas, Micaela Gaudio, Claudia Gutiérrez, Nicolás F Cordeiro, Virginia García-Fulgueiras, Lucía Araújo Pirez, Verónica Seija, Julio C Medina, Gloria Rieppi, Bruno Gonzalez-Zorn, Rafael Vignoli
Carbapenem-resistant Acinetobacter baumannii (CRAB) infections are an increasing concern in intensive care units (ICUs) worldwide. The combination of carbapenemases and 16S rRNA-methyltransferases (16S-RMTases) further reduces the therapeutic options. OXA-carbapenemase/A. baumannii clone tandems in Latin America have already been described; however, no information exists in this region regarding the occurrence of 16S-RMTases in this microorganism. In addition, the epidemiology of A. baumannii in ICUs and its associated resistance profiles are poorly understood...
June 19, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29920142/control-comparison-of-the-new-endowrist-and-traditional-laparoscopic-staplers-for-anterior-rectal-resection-with-the-da-vinci-xi
#10
Simone Guadagni, Gregorio Di Franco, Desirée Gianardi, Matteo Palmeri, Cristina Ceccarelli, Matteo Bianchini, Niccolò Furbetta, Giovanni Caprili, Cristiano D'Isidoro, Andrea Moglia, Franca Melfi, Piero Buccianti, Franco Mosca, Luca Morelli
BACKGROUND: A new robotic stapler for the da Vinci Xi® is directly controlled by the surgeon at the console and equipped with EndoWrist® technology. We evaluated operative and short-term results of the first patients who underwent anterior rectal resection for cancer with the da Vinci Xi and new staplers, and compared the results with those of a comparable group treated with traditional laparoscopic staplers. METHODS: From December 2015 to December 2017, 25 patients underwent anterior rectal resection for cancer with robotic EndoWrist staplers (EndoWrist group)...
June 19, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29917237/the-extracellular-matrix-glycoprotein-tenascin-x-regulates-peripheral-sensory-and-motor-neurones
#11
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R Tough, Paulo Watanabe, Eduardo J A Araujo, Sahar D Mohammed, Jean-Marie Delalande, David C Bulmer, S Mark Scott, Helen M Cox, Nicol C Voermans, Qasim Aziz, L Ashley Blackshaw
The extracellular matrix (ECM) is not only an integral structural molecule, but is also critical for a wide range of cellular functions. The glycoprotein tenascin-X (TNX) predominates in the ECM of tissues like skin and regulates tissue structure through anti-adhesive interactions with collagen. Monogenic TNX deficiency causes painful joint hypermobility and skin hyperelasticity, symptoms characteristic of hypermobility-Ehlers Danlos Syndrome (hEDS). hEDS patients also report consistently increased visceral pain and gastrointestinal (GI) dysfunction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29916919/uterine-corpus-metastasis-from-rectal-adenocarcinoma-detected-using-18f-fdg-pet-ct
#12
Hongxi Wang, Minggang Su, Futao Cui, Xia Wu, Rong Tian
We report an unusual case of uterine corpus metastasis from rectal adenocarcinoma detected using F-FDG PET/CT. A 47-year-old woman was diagnosed with rectal adenocarcinoma and treated with surgery and radiochemotherapy 3 years ago. During follow-up, she presented with lower abdomen pain and elevated tumor markers, but ultrasonography findings were unremarkable. We performed an F-FDG PET/CT scan, which showed intense F-FDG avidity in the myometrium of the uterine corpus. Uterine corpus metastasis was suspected, and complementary MRI and diagnostic curettage histopathology confirmed uterine metastasis from rectal adenocarcinoma...
June 19, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29916871/a-multicenter-matched-comparison-of-transanal-and-robotic-total-mesorectal-excision-for-mid-and-low-rectal-adenocarcinoma
#13
Lawrence Lee, Borja de Lacy, Marcos Gomez Ruiz, Alexander Sender Liberman, Matthew R Albert, John R T Monson, Antonio Lacy, Seon Hahn Kim, Sam B Atallah
OBJECTIVE: To compare the quality of surgical resection of transanal total mesorectal excision (TA-TME) and robotic total mesorectal excision (R-TME). BACKGROUND: Both TA-TME and R-TME have been advocated to improve the quality of surgery for rectal cancer below 10 cm from the anal verge, but there are little data comparing TA-TME and R-TME. METHODS: Data of patients undergoing TA-TME or R-TME for rectal cancer below 10 cm from the anal verge and a sphincter-saving procedure from 5 high-volume rectal cancer referral centers between 2011 and 2017 were obtained...
June 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29916491/a-novel-endoscopic-technique-to-obtain-rectal-biopsy-specimens-in-children-with-suspected-hirschsprung-s-disease
#14
Zaheer Nabi, Radhika Chavan, Upender Shava, Anuradha Sekharan, D Nageshwar Reddy
No abstract text is available yet for this article.
May 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29915739/awareness-of-colorectal-cancer-among-public-in-asir-region
#15
Mohammad Nassir Al-Sharif, Khalid Ali Fayi, Abdulsalam Ali Alobaidi, Bader Awadh Alshamrani
Introduction: Colorectal cancer (CRC) has different forms of colon cancer or rectal cancer. CRCs are often considered together because they possess many similar features. A severe form of the disease with higher mortality rate increases with increase in age. The most common CRC risk factors include smoking, diabetes, and obesity. This study aims to evaluate the awareness of CRC in a random population of Asir region and to identify the subpopulation that can be recipients of awareness and screening programs...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915399/anatomical-and-functional-features-of-the-internal-rectal-prolapse-with-outlet-obstruction-determined-with-3d-endorectal-ultrasonography-and-high-resolution-anorectal-manometry-an-observational-case-control-study
#16
Luigi Brusciano, Salvatore Tolone, Paolo Limongelli, Gianmattia Del Genio, Federico Messina, Jacopo Martellucci, Mariachiara Lanza Volpe, Antonio Longo, Ludovico Docimo
OBJECTIVES: To investigate correlation between rectal wall thickness (RWT) and anorectal pressures, in obstructed defecation syndrome (ODS) patients caused by internal rectal prolapse. METHODS: ODS patients and healthy volunteers (HVs) underwent 3D endorectal ultrasound (3D-EUS) and high-resolution anorectal manometry (HRAM); RWT, total rectal wall volume (TRWV), pushing endorectal pressure (PEP), recto-anal gradient were determined RESULTS: We enrolled 35 ODS patients and 25 HVs...
June 19, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29914698/physiological-and-perceptual-responses-in-the-elderly-to-simulated-daily-living-activities-in-uk-summer-climatic-conditions
#17
K A M Waldock, M Hayes, P W Watt, N S Maxwell
OBJECTIVES: The elderly population is at an increasingly significant health risk to heat-related illnesses and mortality when compared with younger people in the same conditions. This is due to an increased frequency and severity of heatwaves, attributed to climate change, and reduced ability of elderly individuals to dissipate excess heat. Consequently, most excess deaths and emergency visits during heatwaves occur in people aged more than 65 years. The aim of this investigation was to assess the physiological and perceptual responses of elderly people during exercise sessions equating to activities of daily living in UK summer climatic conditions...
June 15, 2018: Public Health
https://www.readbyqxmd.com/read/29914478/community-understanding-of-the-concept-of-pre-referral-treatment-and-how-this-impacts-on-referral-related-decision-making-following-the-provision-of-rectal-artesunate-a-qualitative-study-in-western-uganda
#18
C E Strachan, A Nuwa, D Muhangi, A P Okui, M E H Helinski, J K Tibenderana
BACKGROUND: Successful pre-referral treatment with rectal artesunate (RA) for suspected severe malaria requires operational linkages between community health workers (CHWs) and referral facilities, acceptance of pre-referral treatment and adherence to referral practices by CHWs and caregivers. This qualitative study investigated how community understanding of the concept of 'pre-referral treatment' is used in referral related decision-making following provision of RA in Uganda. METHODS: Narrative interviews were conducted with 30 caregivers of children under five who received RA within the previous three months and the 30 associated CHWs who provided the treatment...
June 19, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29914474/pharmacokinetics-of-rectal-levetiracetam-as-add-on-treatment-in-dogs-affected-by-cluster-seizures-or-status-epilepticus
#19
Giulia Cagnotti, Rosangela Odore, Giulia Gardini, Stefano Amedeo, Iride Bertone, Giulia Guerriero, Laura Lentini, Elena Dappiano, Antonio D'Angelo
BACKGROUND: Levetiracetam can be used for seizure control alone or in combination with other antiepileptic medications. A previous study achieved the minimum targeted serum drug concentration after rectal administration of levetiracetam in healthy dogs. The purpose of the present study was to determine the pharmacokinetics of rectal LEV in dogs presented for cluster seizures or status epilepticus and potentially in treatment with other anti-epileptic drugs. Furthermore, preliminary information on response to this treatment as add-on to the standard treatment protocol is reported...
June 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29914424/knowledge-attitudes-and-misconceptions-of-italian-healthcare-professionals-regarding-fever-management-in-children
#20
Elena Chiappini, Antonina Marta Cangelosi, Paolo Becherucci, Monica Pierattelli, Luisa Galli, Maurizio de Martino
BACKGROUND: Fever phobia is still a major issue in paediatrics. We report knowledge of a sample of Italian paediatricians performed six years after the release of the Italian guidelines for the management of fever in children (IFG). METHODS: A questionnaire, developed following the IFG recommendations and previously administered to 300 paediatricians in 2012, was proposed to all the paediatricians attending the 2015 National Congress of Practice Paediatrics, held in Florence, Italy...
June 18, 2018: BMC Pediatrics
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