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https://www.readbyqxmd.com/read/29050227/identification-of-two-novel-biomarkers-of-rectal-carcinoma-progression-and-prognosis-via-co-expression-network-analysis
#1
Min Sun, Taojiao Sun, Zhongshi He, Bin Xiong
mRNA expression profiles provide important insights on a diversity of biological processes involved in rectal carcinoma (RC). Our aim was to comprehensively map complex interactions between the mRNA expression patterns and the clinical traits of RC. We employed the integrated analysis of five microarray datasets and The Cancer Genome Atlas rectal adenocarcinoma database to identify 2118 consensual differentially expressed genes (DEGs) in RC and adjacent normal tissue samples, and then applied weighted gene co-expression network analysis to parse DEGs and eight clinical traits in 66 eligible RC samples...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050194/update-on-the-pathophysiology-and-management-of-anorectal-disorders
#2
REVIEW
Tanisa Patcharatrakul, Satish S C Rao
Anorectal disorders are common and present with overlapping symptoms. They include several disorders with both structural and functional dysfunction(s). Because symptoms alone are poor predictors of the underlying pathophysiology, a diagnosis should only be made after evaluating symptoms and physiologic and structural abnormalities. A detailed history, a thorough physical and digital rectal examination and a systematic evaluation with high resolution and/or high definition three-dimensional (3D) anorectal manometry, 3D anal ultrasonography, magnetic resonance defecography and neurophysiology tests are essential to correctly identify these conditions...
October 23, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29050171/-use-of-prostate-health-index-in-diagnosing-prostate-cancer-in-chinese-men
#3
Y Zhu, B Tang, B Dai, X J Qin, X L Lu, D W Ye
Objective: To investigate the value of prostate health index (PHI) in the diagnosis of prostate cancer in patients with total prostate specific antigen (tPSA) <20 μg/L. Methods: Totally 1 135 patients with tPSA<20 μg/L and prostate biopsy indications at Department of Urology, Fudan University Shanghai Cancer Center from March 2013 to April 2016 were enrolled in this study. They were tested for serum tPSA, free prostate specific antigen and prostate specific antigen isoform 2, from which PHI was calculated...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29049477/association-of-the-addition-of-oral-antibiotics-to-mechanical-bowel-preparation-for-left-colon-and-rectal-cancer-resections-with-reduction-of-surgical-site-infections
#4
Elaine Vo, Nader N Massarweh, Christy Y Chai, Hop S Tran Cao, Nader Zamani, Sherry Abraham, Kafayat Adigun, Samir S Awad
Importance: Surgical site infections (SSIs) after colorectal surgery remain a significant complication, particularly for patients with cancer, because they can delay the administration of adjuvant therapy. A combination of oral antibiotics and mechanical bowel preparation (MBP) is a potential, yet controversial, SSI prevention strategy. Objective: To determine the association of the addition of oral antibiotics to MBP with preventing SSIs in left colon and rectal cancer resections and its association with the timely administration of adjuvant therapy...
October 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049220/the-association-between-ccnd1-g870a-polymorphism-and-colorectal-cancer-risk-a-meta-analysis
#5
Mei Xie, Fen Zhao, Xiaoling Zou, Shuai Jin, Shaoquan Xiong
BACKGROUND: CyclinD1 (CCND1) is a key cell cycle regulatory protein. A large number of epidemiological studies have assessed the potential correlation between the CCND1 G870A polymorphism and the risk of colorectal cancer (CRC), but their findings have been inconsistent. To obtain a more precise understanding of the association between the G870A polymorphism in the CCND1 gene and the CRC risk, we conducted a more comprehensive meta-analysis. METHODOLOGY: We searched PubMed, Ovid, Springer, Weipu, China National Knowledge Infrastructure (CNKI), and Wanfang databases, covering all publications (the last search was updated on January 10, 2017)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049009/seroepidemiology-of-coxsackievirus-b5-in-infants-and-children-in-jiangsu-province-china
#6
Fan Gao, Lianlian Bian, Xiaotian Hao, Yalin Hu, Xin Yao, Shiyang Sun, Pan Chen, Ce Yang, Ruixiao Du, Jingxin Li, Fengcai Zhu, Qunying Mao, Zhenglun Liang
Coxsackievirus B5 (CV-B5) is associated with various human diseases such as viral encephalitis, aseptic meningitis, paralysis, herpangina, and hand, foot and mouth disease (HFMD). However, there is currently no effective vaccine against CV-B5.The seroepidemiologic characteristics of CV-B5 remained unknown. A cohort study was carried out in 176 participants aged 6-35 months from January 2012 to January 2014. The serum samples were collected and tested for CV-B5 neutralizing antibodies (NtAbs) four times during these two years...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048575/microrna-binding-site-polymorphisms-in-genes-involved-in-colorectal-cancer-etiopathogenesis-and-their-impact-on-disease-prognosis
#7
Michaela Schneiderova, Alessio Naccarati, Barbara Pardini, Fabio Rosa, Cornelia Di Gaetano, Katerina Jiraskova, Alena Opattova, Miroslav Levy, Karel Veskrna, Veronika Veskrnova, Tomas Buchler, Stefano Landi, Pavel Vodicka, Veronika Vymetalkova
According to the Vogelstein's model of colorectal carcinogenesis, genetic variations in highly penetrant genes may be involved in the colorectal cancer (CRC) pathogenesis. Similarly, aberrant function and/or altered expression of microRNAs (miRNAs) often occur in CRC. In this context, polymorphisms in miRNA-binding sites (miRSNPs) may affect miRNA/target gene interaction, resulting in differential mRNA/protein expression and increased susceptibility to common diseases. To explore this phenomenon, we have mined the 3' untranslated regions (3'UTRs) of genes known to be frequently mutated in CRC to search for miRSNPs and tested their association with CRC risk and clinical outcome...
October 17, 2017: Mutagenesis
https://www.readbyqxmd.com/read/29048285/high-level-fosfomycin-resistance-in-vancomycin-resistant-enterococcus-faecium
#8
Yan Guo, Adam D Tomich, Christi L McElheny, Vaughn S Cooper, Amelia Tait-Kamradt, Minggui Wang, Fupin Hu, Louis B Rice, Nicolas Sluis-Cremer, Yohei Doi
Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29048263/capture-and-immobilization-of-african-wolves-canis-lupaster-in-the-ethiopian-highlands
#9
Tariku Mekonnen Gutema, Anagaw Atickem, Alemayehu Lemma, Afework Bekele, Claudio Sillero-Zubiri, Dietmar Zinner, Wenche Kristin Farstad, Jon M Arnemo, Nils C Stenseth
We captured 14 individual African wolves (Canis lupaster) a total of 16 times in the Ethiopian Highlands in April 2015 and March 2016 by using rubber-lined foothold traps and immobilized them with dexmedetomidine-ketamine. Traps were baited with sheep meat and surveyed every 2 h. Capture efficiency (number of captures per number of visits) was 0.94, and capture rate (number of captures per number of trap nights) was 0.24. Trapped wolves were immobilized with 0.025 mg/kg dexmedetomidine and 8-10 mg/kg ketamine on the basis of respective estimated body mass...
October 19, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29048218/radiotherapy-for-patients-with-resected-tumor-deposit-positive-colorectal-cancer-a-surveillance-epidemiology-and-end-results-based-population-study
#10
Laxmi B Chavali, Adana A M Llanos, Jing-Ping Yun, Stephanie M Hill, Xiang-Lin Tan, Lanjing Zhang
CONTEXT: - According to the American Joint Committee on Cancer's Cancer Staging Manual, 7th edition, TNM classification, tumor deposit (TD)-positive colorectal cancers (CRCs) are classified as N1c. The effects of radiotherapy and the effects of the updated American Joint Committee on Cancer 7th edition TNM N1c classification for patients with TD-positive CRC are unclear. OBJECTIVE: - To investigate outcomes of radiotherapy in patients with resected TD-positive CRC...
October 19, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29048208/an-innovative-technique-of-transurethral-seminal-vesiculoscopy-with-ultrasonic-lithotripter-for-severe-persistent-hematospermia
#11
Wei Zhang, Guang'an Xiao, Shenfei Qin, Amanda B Reed-Maldonado, Jian Xu, Guanghua Chen, Lei Wang, Tie Zhou
BACKGROUND AND PURPOSE: Transurethral seminal vesiculoscopy (TSV) provides an efficient approach to diagnose and treat the hematospermia but still need further improvement in manipulation and corresponding instruments. In this study, we develop an innovative technique with ultrasonic lithotripter (EMS) to treat severe, persistent hematospermia. PATIENTS AND METHODS: Data of patients who underwent TSV with or without ultrasonic lithotripter between May 2012 and December 2015 was reviewed...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29047422/mycoplasma-genitalium-infection-in-adults-reporting-sexual-contact-with-infected-partners-australia-2008-2016
#12
Josephine B Slifirski, Lenka A Vodstrcil, Christopher K Fairley, Jason J Ong, Eric P F Chow, Marcus Y Chen, Timothy R H Read, Catriona S Bradshaw
Data on the likelihood of Mycoplasma genitalium infection in sexual contacts, particularly for men who have sex with men (MSM), are needed to form an evidence base for guidelines. We conducted a cross-sectional analysis of patients attending a sexual health clinic in Melbourne, Victoria, Australia, during 2008-2016. We calculated the proportion of contacts with M. genitalium infection and determined factors associated with infection. Among those patients reporting sexual contact with an M. genitalium-infected person, 48...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29047070/predictive-factors-for-lymph-node-metastasis-and-prognostic-factors-for-survival-in-rectal-neuroendocrine-tumors
#13
Beonghoon Sohn, Yoomin Kwon, Seung-Bum Ryoo, Inho Song, Yoon-Hye Kwon, Dong Woon Lee, Sang Hui Moon, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park
INTRODUCTION: Neuroendocrine tumors have malignant potential, and lymph node metastasis can occur. This study aimed to identify predictive factors of lymph node metastasis and prognostic factors for survival in rectal neuroendocrine tumors. METHODS: Sixty-four patients underwent endoscopic or surgical treatment for rectal NET. The data on these patients were collected in our database prospectively and reviewed retrospectively. RESULTS: Transanal excision was performed in 28 (43...
October 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29046951/time-trends-in-colorectal-cancer-early-postoperative-mortality-a-french-25-year-population-based-study
#14
Sylvain Manfredi, Valérie Jooste, Caroline Gay, Jean Faivre, Antoine Drouillard, Anne-Marie Bouvier
BACKGROUND: Postoperative mortality after resection of colorectal cancer is an important issue. The aim of this study was to assess early postoperative mortality in a well-defined French population. METHODS: Data on 30- and 90-day postoperative mortality after resection for colorectal cancer were extracted from the digestive cancer registry of Burgundy. Time trends of postoperative mortality between 1989 and 2013 were described for the large population. Case-control studies (death within 30 or 90 days = cases, alive at 90 days = controls) focused on the association between postoperative mortality and surgical approach, obesity and other comorbidities over the last [2010-2013] period, using conditional logistic regressions...
October 19, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29046927/fdg-pet-ct-radiomics-for-predicting-the-outcome-of-locally-advanced-rectal-cancer
#15
Pierre Lovinfosse, Marc Polus, Daniel Van Daele, Philippe Martinive, Frédéric Daenen, Mathieu Hatt, Dimitris Visvikis, Benjamin Koopmansch, Frédéric Lambert, Carla Coimbra, Laurence Seidel, Adelin Albert, Philippe Delvenne, Roland Hustinx
PURPOSE: The aim of this study was to investigate the prognostic value of baseline (18)F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC underwent (18)F-FDG PET/CT before treatment. Maximum and mean standard uptake values (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), histogram-intensity features, as well as 11 local and regional textural features, were evaluated...
October 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29046790/intraluminal-rectal-cancer-metastasis-to-the-small-bowel-an-extremely-rare-case-report
#16
Paraskevas Stamopoulos, Nikolaos Machairas, Stylianos Kykalos, Afrodite Nonni, Gregory Kouraklis, Georgios C Sotiropoulos
Prolonged survival in patients suffering from colorectal cancer (CRC) may lead to the emergence of rare metastatic sites that are not well-documented in the literature. We herein describe a very rare case of an intraluminal small intestinal metastasis in a patient with previously resected CRC. A 71-year-old Caucasian male patient with a history of rectosigmoid junction cancer was initially treated with anterior resection. The tumor was classified as pT3pN0 (0/26) M0, stage II. Eighteen months after the primary surgery, local recurrence was detected in the presacral region, and the patient received combined image-guided radiotherapy and chemotherapy...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046789/a-retrospective-study-of-late-adverse-events-in-proton-beam-therapy-for-prostate-cancer
#17
Hirokazu Makishima, Hitoshi Ishikawa, Keiichi Tanaka, Yutaro Mori, Masashi Mizumoto, Kayoko Ohnishi, Teruhito Aihara, Nobuyoshi Fukumitsu, Toshiyuki Okumura, Hideyuki Sakurai
The efficacy and safety of proton beam therapy (PBT) were retrospectively evaluated in 111 consecutive patients with prostate cancer who underwent definitive PBT between 2008 and 2012. Following exclusion of 18 patients due to treatment suspension, loss to follow-up, and histology, the analysis included 93 patients with a median age of 68 years (range, 49-81 years). A total of 7, 32 and 54 prostate cancer patients were classified as low-, intermediate- and high-risk, respectively, as follows: High-risk, T≥3a or prostate-specific antigen (PSA) ≥20 ng/ml or Gleason Score ≥8; low-risk, T ≤2b and PSA≤10 ng/ml and Gleason Score=6; intermediate-risk, all other combinations...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29045351/awareness-and-implementation-of-the-2014%C3%A2-espghan-naspghan-guideline-for-childhood-functional-constipation
#18
Ilan J N Koppen, M H Vriesman, M M Tabbers, C Di Lorenzo, M A Benninga
OBJECTIVE: To assess if physicians approach children with functional constipation according to the 2014 ESPGHAN/NASPGHAN guideline. METHODS: We invited pediatricians and pediatric gastroenterologists in the Netherlands and the U.S. to participate in this anonymous survey using a self-developed questionnaire containing 19 multiple-choice questions concerning evaluation and treatment of children with constipation. RESULTS: We included 328 physicians (67% from the U...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29045260/encopresis-plus
#19
DePorres Cormier, Marie Reilly, Amy Young, Marilyn Augustyn
Dexter is a 12-year-old boy who presents with his maternal grandmother for follow-up to primary care for secondary encopresis. Dexter presented, 18 months ago, with a 3-month history of secondary encopresis. At that time, a comprehensive assessment revealed functional constipation resulting in encopresis. Dexter's symptoms resolved with a combination of medication management and behavioral strategies; laxatives were discontinued 12 months ago.Dexter's grandmother reports that for the past 6 months, her grandson developed encopresis once again...
October 17, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29045026/feasibility-of-laparoscopic-surgery-after-stent-insertion-for-obstructive-colorectal-cancer
#20
Hideharu Shimizu, Ryoto Yamazaki, Hideo Ohtsuka, Itaru Osaka, Kunio Takuma, Yasuhiro Morita
INTRODUCTION: A growing number of patients with obstructive colorectal cancer are being treated with self-expanding metallic stents (SEMS) followed by laparoscopic resection. The aim of this study was to assess the feasibility of stent insertion and laparoscopic surgery for obstructive colorectal cancer and to compare these outcomes to regular laparoscopic surgery for non-obstructive colorectal cancer. METHODS: We retrospectively analyzed the outcomes of patients with a malignant colonic obstruction who underwent SEMS placement followed by elective laparoscopic resection...
October 17, 2017: Asian Journal of Endoscopic Surgery
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