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https://www.readbyqxmd.com/read/28591594/oleanolic-bioenhancer-coloaded-chitosan-modified-nanocarriers-attenuate-breast-cancer-cells-by-multimode-mechanism-and-preserve-female-fertility
#1
Monika Sharma, Shweta Sharma, Vikas Sharma, Komal Sharma, Santosh Kumar Yadav, Pankaj Dwivedi, Satish Agrawal, Sarvesh Kumar Paliwal, Anil Kumar Dwivedi, Jagdamba Prasad Maikhuri, Gopal Gupta, Prabhat Ranjan Mishra, Ajay Kumar Singh Rawat
Addressing multidrug resistant stage of breast cancer is an impediment for chemotherapy. Moreover, breast cancer chemotherapy has potential enduring confrontations i.e. related toxicity including effect on fertility of young female patients. The co-delivery of polyphenolic bio-enhancers with oleanolic acid in chitosan coated PLGA nanoparticles was designed for oral delivery with enhanced antitumor effect consecutively preserving the female fertility. The optimized oleanolic- bio-enhancer nano formulation CH-OA-B-PLGA with particle size was 342...
June 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28541169/imagining-moral-bioenhancement-practices-drawing-inspiration-from-moral-education-public-health-ethics-and-forensic-psychiatry
#2
Jona Specker, Maartje H N Schermer
In this article, we consider contexts or domains in which (future) moral bioenhancement interventions possibly or most likely will be implemented. By looking closely at similar or related existing practices and their relevant ethical frameworks, we hope to identify ethical considerations that are relevant for evaluating potential moral bioenhancement interventions. We examine, first, debates on the proper scope of moral education; second, proposals for identifying early risk factors for antisocial behaviour; and third, the difficult balancing of individual freedom and third party concerns in (forensic) psychiatry...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541168/commentary-moral-bioenhancement-worthy-of-the-name
#3
Robert Sparrow
No abstract text is available yet for this article.
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541167/would-we-even-know-moral-bioenhancement-if-we-saw-it
#4
Harris Wiseman
The term "moral bioenhancement" conceals a diverse plurality encompassing much potential, some elements of which are desirable, some of which are disturbing, and some of which are simply bland. This article invites readers to take a better differentiated approach to discriminating between elements of the debate rather than talking of moral bioenhancement "per se," or coming to any global value judgments about the idea as an abstract whole (no such whole exists). Readers are then invited to consider the benefits and distortions that come from the usual dichotomies framing the various debates, concluding with an additional distinction for further clarifying this discourse qua explicit/implicit moral bioenhancement...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541166/moral-bioenhancement-and-free-will-continuing-the-debate
#5
Vojin Rakić
This article continues and expands differences I have with Ingmar Persson and Julian Savulescu concerning issues of moral bioenhancement and free will. They have criticized my conception of voluntary moral bioenhancement, claiming that it ignores the extent to which freedom is a matter of degree. Here, I argue that freedom as a political concept (or as one that is analogous to a political concept) is indeed scalar in nature, but that freedom of the will is to be understood as a threshold concept and therefore not as subject to degree...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541165/is-it-desirable-to-be-able-to-do-the-undesirable-moral-bioenhancement-and-the-little-alex-problem
#6
Michael Hauskeller
It has been argued that moral bioenhancement is desirable even if it would make it impossible for us to do what is morally required. Others find this apparent loss of freedom deplorable. However, it is difficult to see how a world in which there is no moral evil can plausibly be regarded as worse than a world in which people are not only free to do evil, but also where they actually do it, which would commit us to the seemingly paradoxical view that, under certain circumstances, the bad can be better than the good...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541163/commentary-freedom-means-self-awareness-and-self-control-bioenhancement-can-help
#7
James Hughes
No abstract text is available yet for this article.
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28447878/development-of-novel-amisulpride-loaded-liquid-self-nanoemulsifying-drug-delivery-systems-via-dual-tackling-of-its-solubility-and-intestinal-permeability
#8
Wael Gamal, Rania H Fahmy, Magdy I Mohamed
OBJECTIVE: The aim of the current investigation was at enhancing the oral biopharmaceutical behavior; solubility and intestinal permeability of amisulpride (AMS) via development of liquid self-nanoemulsifying drug delivery systems (L-SNEDDS) containing bioenhancing excipients. METHODS: The components of L-SNEDDS were identified via solubility studies and emulsification efficiency tests, and ternary phase diagrams were constructed to identify the efficient self-emulsification regions...
May 11, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28356492/the-moral-bioenhancement-of-psychopaths
#9
Elvio Baccarini, Luca Malatesti
We argue that the mandatory moral bioenhancement of psychopaths is justified as a prescription of social morality. Moral bioenhancement is legitimate when it is justified on the basis of the reasons of the recipients. Psychopaths expect and prefer that the agents with whom they interact do not have certain psychopathic traits. Particularly, they have reasons to require the moral bioenhancement of psychopaths with whom they must cooperate. By adopting a public reason and a Kantian argument, we conclude that we can justify to a psychopath being the recipient of mandatory moral bioenhancement because he has a reason to require the application of this prescription to other psychopaths...
March 29, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28300281/moral-hard-wiring-and-moral-enhancement
#10
Ingmar Persson, Julian Savulescu
We have argued for an urgent need for moral bioenhancement; that human moral psychology is limited in its ability to address current existential threats due to the evolutionary function of morality to maximize cooperation in small groups. We address here Powell and Buchanan's novel objection that there is an 'inclusivist anomaly': humans have the capacity to care beyond in-groups. They propose that 'exclusivist' (group-based) morality is sensitive to environmental cues that historically indicated out-group threat...
March 16, 2017: Bioethics
https://www.readbyqxmd.com/read/28224392/investigation-of-need-of-natural-bioenhancer-for-a-metabolism-susceptible-drug-raloxifene-in-a-designed-self-emulsifying-drug-delivery-system
#11
Poonam Singh Thakur, Narinder Singh, Abhay T Sangamwar, Arvind Kumar Bansal
Bioenhancers can increase the bioavailability of metabolism susceptible drugs. The present study was designed to understand the impact of bioenhancer on permeability and bioavailability of a biopharmaceutical drug disposition classification system (BDDCS) class II drug raloxifene (RLX). RLX undergoes extensive first pass metabolism by UGT enzymes in gastrointestinal tract (GIT) and has an oral bioavailability of about 2%. Self-emulsifying drug delivery system (SEDDS) of RLX was developed using a designed approach and this formulation was loaded with reported bioenhancers: quercetin and piperine...
February 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27976272/resveratrol-as-a-bioenhancer-to-improve-anti-inflammatory-activities-of-apigenin
#12
S K Ha
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27917247/moral-blindness-the-gift-of-the-god-machine
#13
John Harris
The continuing debate between Persson and Savulescu and myself over moral enhancement concerns two dimensions of a very large question. The large question is: what exactly makes something a moral enhancement? This large question needs a book length study and this I provide in my How to be Good, Oxford 2016. (JH 2016). In their latest paper Moral Bioenhancement, Freedom and Reason take my book as their point of departure and the first dimension of the big question they address is one that emphasizes a distinction, not highlighted in their original 2008 paper, between a moral enhancement that will ensure an improvement in morality and one that will simply make people more motivated to be moral...
2016: Neuroethics
https://www.readbyqxmd.com/read/27917246/moral-bioenhancement-freedom-and-reason
#14
Ingmar Persson, Julian Savulescu
In this paper we reply to the most important objections to our advocacy of moral enhancement by biomedical means - moral bioenhancement - that John Harris advances in his new book How to be Good. These objections are to effect that such moral enhancement undercuts both moral reasoning and freedom. The latter objection is directed more specifically at what we have called the God Machine, a super-duper computer which predicts our decisions and prevents decisions to perpertrate morally atrocious acts. In reply, we argue first that effective moral bioenhancement presupposes moral reasoning rather than undermines it...
2016: Neuroethics
https://www.readbyqxmd.com/read/27853890/neuroprotective-potential-of-curcumin-in-combination-with-piperine-against-6-hydroxy-dopamine-induced-motor-deficit-and-neurochemical-alterations-in-rats
#15
Shamsher Singh, Puneet Kumar
AIM AND OBJECTIVE: 6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the antioxidant, neuromodulatory and neuroprotective mechanisms. MATERIALS AND METHODS: Hemi-Parkinson's rat model was developed with intranigral infusion of 6-OHDA (8 μg/2 μl, once, unilaterally), treatment with CMN (25 and 50 mg/kg) and combination of PP (2...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/27805329/role-of-risorine-in-the-treatment-of-drug-susceptible-pulmonary-tuberculosis-a-pilot-study
#16
Agam Vora, Sanjay Patel, Kamlesh Patel
OBJECTIVE: To study the efficacy and tolerability of Risorine Capsule (A fixed dose combination of Rifampicin 200 mg + INH 300 mg + Piperine 10 mg) therapy in the treatment of drug-susceptible pulmonary tuberculosis patients who developed GI intolerance with standard WHO anti TB regimen. METHODS: 33 patients with pulmonary tuberculosis were treated with one Risorine kit, daily consisting of one capsule of Risorine, one tablet of ethambutol (800 mg) and two tablets of Pyrazinamide 750 mg each, for first two months of therapy...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27783266/bringing-curcumin-to-the-clinic-in-cancer-prevention-a-review-of-strategies-to-enhance-bioavailability-and-efficacy
#17
Rama I Mahran, Magda M Hagras, Duxin Sun, Dean E Brenner
Curcumin is widely available, inexpensive spice that has been used in ancient folk medicine for millennia, especially in India. Curcumin has the pharmacological properties that slow or reverse cellular proliferation and enhance apoptosis and differentiation associated with a diverse array of molecular effects. Despite its effective anticarcinogenesis properties, curcumin's poor solubility, instability, and extensive metabolism result in poor oral bioavailability. Strategies to enhance curcumin delivery include encapsulating or incorporating curcumin in a nanoparticle or microparticle drug delivery system, synthesizing more stable curcumin analogs that resist metabolism while retaining curcumin's pharmacological properties, and adding another natural product that has bioenhancing properties to curcumin or combination of two of these strategies...
January 2017: AAPS Journal
https://www.readbyqxmd.com/read/27558776/climate-change-cooperation-and-moral-bioenhancement
#18
Toby Handfield, Pei-Hua Huang, Robert Mark Simpson
The human faculty of moral judgement is not well suited to address problems, like climate change, that are global in scope and remote in time. Advocates of 'moral bioenhancement' have proposed that we should investigate the use of medical technologies to make human beings more trusting and altruistic and hence more willing to cooperate in efforts to mitigate the impacts of climate change. We survey recent accounts of the proximate and ultimate causes of human cooperation in order to assess the prospects for bioenhancement...
August 24, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27392772/optimization-design-of-isradipine-loaded-solid-lipid-nanobioparticles-using-rutin-by-taguchi-methodology
#19
Vikash Kumar, Rajeev Kharb, Hema Chaudhary
Our research objective was to optimize and design nano-biosystem of Isradipine (IDP) via novel bioenhancer (Rutin) loaded solid-lipid nanobioparticles (ANbp) using Taguchi design (TgD) methodology. Firstly, preliminary screening of solid lipid nanoparticles (SLNps) formulation core factors (A, B & C; Lipoid's, poly-acid, sonication time respectively at fixed dose of model drug were assessed on entrapment efficiency & particle size; R1 & R2) by performed experimentally of three factor three levels orthogonal L27 array...
November 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27343364/use-of-a-non-covalent-cell-penetrating-peptide-strategy-to-enhance-the-nasal-delivery-of-interferon-beta-and-its-pegylated-form
#20
Yuko Iwase, Noriyasu Kamei, El-Sayed Khafagy, Mitsuko Miyamoto, Mariko Takeda-Morishita
The conjugation of therapeutic proteins to polyethylene glycol (PEG) is known as PEGylation. It improves their retention in the body and reduces the frequency of injections. Development of noninvasive delivery systems for biopharmaceuticals can improve the patients' quality of life. The present study aimed to evaluate the cell-penetrating peptides (CPPs), which act as bioenhancers, for the nasal delivery of protein drug interferon beta (IFN-β) and its PEGylated form (PEG-IFN-β). The ability of CPPs to enhance the nasal mucosal absorption of unmodified IFN-β was assessed in rats...
August 20, 2016: International Journal of Pharmaceutics
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