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https://www.readbyqxmd.com/read/28711639/skin-permeability-enhancement-by-bacillus-subtilis-alkaline-protease-application-to-transdermal-drug-delivery
#1
Mohamed I Nounou, Taha I Zaghloul, Nehal A Ahmed, Amira A Eid, Labiba K El-Khordagui
Enzymes may offer great potentials in topical pharmaceutical applications provided that treatment conditions are controlled for efficacy and safety. In this study, the effect of alkaline protease produced by recombinant Bacillus subtilis cells on the ex-vivo permeability of rabbit ear skin was investigated under different conditions of enzyme activity (5-60 units) and exposure time (15-60min). Data for transepidermal water loss (TEWL) and permeation of a hydrophilic dye, rhodamine B (Rb), indicated biphasic activity-dependent and exposure time-dependent skin permeability...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28710657/bioenhancement-of-morality
#2
EDITORIAL
Bert Gordijn, Henk Ten Have
No abstract text is available yet for this article.
July 14, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28694767/development-of-a-new-rutin-nanoemulsion-and-its-application-on-prostate-carcinoma-pc3-cell-line
#3
Mohammad Ahmad, - Sahabjada, Juber Akhtar, Arshad Hussain, - Badaruddeen, Md Arshad, Anuradha Mishra
Biological effects of rutin bioactive are limited due to its poor oral bioavailability and its degradation in aqueous environments. For the purpose of bioenhancement, different nanoemulsion systems of rutin were developed by aqueous titration method using water as dispersion media. The nanoemulsion systems were characterized for surface morphology, droplet size, polydispersity index, zeta potential, in vitro release profile and the formulations were optimized. The anticancer potential of optimized nanoemulsion was evaluated by cells viability (MTT) assay, nuclear condensation, and ROS activity using human prostate cancer (PC3) cell line...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28680077/facilitation-of-phosphorus-uptake-in-maize-plants-by-mycorrhizosphere-bacteria
#4
Fabio Battini, Mette Grønlund, Monica Agnolucci, Manuela Giovannetti, Iver Jakobsen
A major challenge for agriculture is to provide sufficient plant nutrients such as phosphorus (P) to meet the global food demand. The sufficiency of P is a concern because of it's essential role in plant growth, the finite availability of P-rock for fertilizer production and the poor plant availability of soil P. This study investigated whether biofertilizers and bioenhancers, such as arbuscular mycorrhizal fungi (AMF) and their associated bacteria could enhance growth and P uptake in maize. Plants were grown with or without mycorrhizas in compartmented pots with radioactive P tracers and were inoculated with each of 10 selected bacteria isolated from AMF spores...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28591594/oleanolic-bioenhancer-coloaded-chitosan-modified-nanocarriers-attenuate-breast-cancer-cells-by-multimode-mechanism-and-preserve-female-fertility
#5
Monika Sharma, Shweta Sharma, Vikas Sharma, Komal Sharma, Santosh Kumar Yadav, Pankaj Dwivedi, Satish Agrawal, Sarvesh Kumar Paliwal, Anil Kumar Dwivedi, Jagdamba Prasad Maikhuri, Gopal Gupta, Prabhat Ranjan Mishra, Ajay Kumar Singh Rawat
Addressing multidrug resistant stage of breast cancer is an impediment for chemotherapy. Moreover, breast cancer chemotherapy has potential enduring confrontations i.e. related toxicity including effect on fertility of young female patients. The co-delivery of polyphenolic bio-enhancers with oleanolic acid in chitosan coated PLGA nanoparticles was designed for oral delivery with enhanced antitumor effect consecutively preserving the female fertility. The optimized oleanolic- bio-enhancer nano formulation CH-OA-B-PLGA with particle size was 342...
June 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28541169/imagining-moral-bioenhancement-practices-drawing-inspiration-from-moral-education-public-health-ethics-and-forensic-psychiatry
#6
Jona Specker, Maartje H N Schermer
In this article, we consider contexts or domains in which (future) moral bioenhancement interventions possibly or most likely will be implemented. By looking closely at similar or related existing practices and their relevant ethical frameworks, we hope to identify ethical considerations that are relevant for evaluating potential moral bioenhancement interventions. We examine, first, debates on the proper scope of moral education; second, proposals for identifying early risk factors for antisocial behaviour; and third, the difficult balancing of individual freedom and third party concerns in (forensic) psychiatry...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541168/commentary-moral-bioenhancement-worthy-of-the-name
#7
Robert Sparrow
No abstract text is available yet for this article.
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541167/would-we-even-know-moral-bioenhancement-if-we-saw-it
#8
Harris Wiseman
The term "moral bioenhancement" conceals a diverse plurality encompassing much potential, some elements of which are desirable, some of which are disturbing, and some of which are simply bland. This article invites readers to take a better differentiated approach to discriminating between elements of the debate rather than talking of moral bioenhancement "per se," or coming to any global value judgments about the idea as an abstract whole (no such whole exists). Readers are then invited to consider the benefits and distortions that come from the usual dichotomies framing the various debates, concluding with an additional distinction for further clarifying this discourse qua explicit/implicit moral bioenhancement...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541166/moral-bioenhancement-and-free-will-continuing-the-debate
#9
Vojin Rakić
This article continues and expands differences I have with Ingmar Persson and Julian Savulescu concerning issues of moral bioenhancement and free will. They have criticized my conception of voluntary moral bioenhancement, claiming that it ignores the extent to which freedom is a matter of degree. Here, I argue that freedom as a political concept (or as one that is analogous to a political concept) is indeed scalar in nature, but that freedom of the will is to be understood as a threshold concept and therefore not as subject to degree...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541165/is-it-desirable-to-be-able-to-do-the-undesirable-moral-bioenhancement-and-the-little-alex-problem
#10
Michael Hauskeller
It has been argued that moral bioenhancement is desirable even if it would make it impossible for us to do what is morally required. Others find this apparent loss of freedom deplorable. However, it is difficult to see how a world in which there is no moral evil can plausibly be regarded as worse than a world in which people are not only free to do evil, but also where they actually do it, which would commit us to the seemingly paradoxical view that, under certain circumstances, the bad can be better than the good...
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28541163/commentary-freedom-means-self-awareness-and-self-control-bioenhancement-can-help
#11
James Hughes
No abstract text is available yet for this article.
July 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28447878/development-of-novel-amisulpride-loaded-liquid-self-nanoemulsifying-drug-delivery-systems-via-dual-tackling-of-its-solubility-and-intestinal-permeability
#12
Wael Gamal, Rania H Fahmy, Magdy I Mohamed
OBJECTIVE: The aim of the current investigation was at enhancing the oral biopharmaceutical behavior; solubility and intestinal permeability of amisulpride (AMS) via development of liquid self-nanoemulsifying drug delivery systems (L-SNEDDS) containing bioenhancing excipients. METHODS: The components of L-SNEDDS were identified via solubility studies and emulsification efficiency tests, and ternary phase diagrams were constructed to identify the efficient self-emulsification regions...
September 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28356492/the-moral-bioenhancement-of-psychopaths
#13
Elvio Baccarini, Luca Malatesti
We argue that the mandatory moral bioenhancement of psychopaths is justified as a prescription of social morality. Moral bioenhancement is legitimate when it is justified on the basis of the reasons of the recipients. Psychopaths expect and prefer that the agents with whom they interact do not have certain psychopathic traits. Particularly, they have reasons to require the moral bioenhancement of psychopaths with whom they must cooperate. By adopting a public reason and a Kantian argument, we conclude that we can justify to a psychopath being the recipient of mandatory moral bioenhancement because he has a reason to require the application of this prescription to other psychopaths...
March 29, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28300281/moral-hard-wiring-and-moral-enhancement
#14
Ingmar Persson, Julian Savulescu
We have argued for an urgent need for moral bioenhancement; that human moral psychology is limited in its ability to address current existential threats due to the evolutionary function of morality to maximize cooperation in small groups. We address here Powell and Buchanan's novel objection that there is an 'inclusivist anomaly': humans have the capacity to care beyond in-groups. They propose that 'exclusivist' (group-based) morality is sensitive to environmental cues that historically indicated out-group threat...
March 16, 2017: Bioethics
https://www.readbyqxmd.com/read/28224392/investigation-of-need-of-natural-bioenhancer-for-a-metabolism-susceptible-drug-raloxifene-in-a-designed-self-emulsifying-drug-delivery-system
#15
Poonam Singh Thakur, Narinder Singh, Abhay T Sangamwar, Arvind Kumar Bansal
Bioenhancers can increase the bioavailability of metabolism susceptible drugs. The present study was designed to understand the impact of bioenhancer on permeability and bioavailability of a biopharmaceutical drug disposition classification system (BDDCS) class II drug raloxifene (RLX). RLX undergoes extensive first pass metabolism by UGT enzymes in gastrointestinal tract (GIT) and has an oral bioavailability of about 2%. Self-emulsifying drug delivery system (SEDDS) of RLX was developed using a designed approach and this formulation was loaded with reported bioenhancers: quercetin and piperine...
February 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27976272/resveratrol-as-a-bioenhancer-to-improve-anti-inflammatory-activities-of-apigenin
#16
S K Ha
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27917247/moral-blindness-the-gift-of-the-god-machine
#17
John Harris
The continuing debate between Persson and Savulescu and myself over moral enhancement concerns two dimensions of a very large question. The large question is: what exactly makes something a moral enhancement? This large question needs a book length study and this I provide in my How to be Good, Oxford 2016. (JH 2016). In their latest paper Moral Bioenhancement, Freedom and Reason take my book as their point of departure and the first dimension of the big question they address is one that emphasizes a distinction, not highlighted in their original 2008 paper, between a moral enhancement that will ensure an improvement in morality and one that will simply make people more motivated to be moral...
2016: Neuroethics
https://www.readbyqxmd.com/read/27917246/moral-bioenhancement-freedom-and-reason
#18
Ingmar Persson, Julian Savulescu
In this paper we reply to the most important objections to our advocacy of moral enhancement by biomedical means - moral bioenhancement - that John Harris advances in his new book How to be Good. These objections are to effect that such moral enhancement undercuts both moral reasoning and freedom. The latter objection is directed more specifically at what we have called the God Machine, a super-duper computer which predicts our decisions and prevents decisions to perpertrate morally atrocious acts. In reply, we argue first that effective moral bioenhancement presupposes moral reasoning rather than undermines it...
2016: Neuroethics
https://www.readbyqxmd.com/read/27853890/neuroprotective-potential-of-curcumin-in-combination-with-piperine-against-6-hydroxy-dopamine-induced-motor-deficit-and-neurochemical-alterations-in-rats
#19
Shamsher Singh, Puneet Kumar
AIM AND OBJECTIVE: 6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the antioxidant, neuromodulatory and neuroprotective mechanisms. MATERIALS AND METHODS: Hemi-Parkinson's rat model was developed with intranigral infusion of 6-OHDA (8 μg/2 μl, once, unilaterally), treatment with CMN (25 and 50 mg/kg) and combination of PP (2...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/27805329/role-of-risorine-in-the-treatment-of-drug-susceptible-pulmonary-tuberculosis-a-pilot-study
#20
Agam Vora, Sanjay Patel, Kamlesh Patel
OBJECTIVE: To study the efficacy and tolerability of Risorine Capsule (A fixed dose combination of Rifampicin 200 mg + INH 300 mg + Piperine 10 mg) therapy in the treatment of drug-susceptible pulmonary tuberculosis patients who developed GI intolerance with standard WHO anti TB regimen. METHODS: 33 patients with pulmonary tuberculosis were treated with one Risorine kit, daily consisting of one capsule of Risorine, one tablet of ethambutol (800 mg) and two tablets of Pyrazinamide 750 mg each, for first two months of therapy...
November 2016: Journal of the Association of Physicians of India
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