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https://www.readbyqxmd.com/read/28325024/balance-quality-assessment-as-an-early-indicator-of-physical-frailty-in-older-people
#1
Aly Chkeir, Doha Safieddine, D Bera, M Collart, J L Novella, M Drame, David J Hewson, Jacques Duchene
Frailty is an increasingly common geriatric condition that results in an increased risk of adverse health outcomes such as falls. The most widely-used means of detecting frailty is the Fried phenotype, which includes several objective measures such as grip strength and gait velocity. One method of screening for falls is to measure balance, which can be done by a range of techniques including the assessment of the Centre of Pressure (CoP) during a balance assessment. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that can evaluate balance quality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324961/an-elementary-model-for-exploring-the-pathogenesis-of-depression
#2
D A Irosh P Fernando
A preliminary model for exploring the pathogenesis of depression that involves genetic and environmental factors is described using a system of linear differential equation. The influence of environmental factors essentially involves random life events, which are modelled using a stochastic differential equation. Different scenarios, including the trajectory of the pathogenesis of depression and immunity, are described by model simulation.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324881/optic-radiation-tractography-and-visual-field-deficits-in-laser-interstitial-thermal-therapy-for-amygdalohippocampectomy-in-patients-with-mesial-temporal-lobe-epilepsy
#3
Dali Yin, John A Thompson, Cornelia Drees, Steven G Ojemann, Lidia Nagae, Victoria S Pelak, Aviva Abosch
BACKGROUND/AIMS: Laser interstitial thermal therapy (LITT) has become an alternative to open-resective surgery for refractory mesial temporal lobe epilepsy (MTLE). Occurrence of visual field defects (VFDs) following open surgery for MTLE is reported at 52-100%. We examined the rate of VFDs following LITT for amygdalohippocampectomy (AHE) and correlated the occurrence of VFDs with damage to the optic radiations, assessed by diffusion tensor tractography (DTI). METHODS: We performed a retrospective analysis of 5 patients who underwent LITT-AHE for medically refractory MTLE...
March 22, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28324753/error-augmentation-feedback-for-lateral-weight-shifting
#4
Kevin O'Brien, Charles R Crowell, James Schmiedeler
This study examines the effect of error augmentation of center of pressure (CoP) visual feedback on the performance of a lateral weight shifting task. Error augmentation emphasizes deviations from a standard CoP trajectory generated from existing data of over 2000 weight shifts collected with young, healthy subjects. Thirty-six subjects completed nine lateral weight shifting sessions, of which four were training sessions between each of the five testing sessions. Half of the subjects received error augmentation feedback during the training sessions, while the other half received the unaltered, control feedback...
March 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28324611/automated-analysis-of-intracellular-dynamic-processes
#5
Yao Yao, Ihor Smal, Ilya Grigoriev, Maud Martin, Anna Akhmanova, Erik Meijering
The study of intracellular dynamic processes is of fundamental importance for understanding a wide variety of diseases and developing effective drugs and therapies. Advanced fluorescence microscopy imaging systems nowadays allow the recording of virtually any type of process in space and time with super-resolved detail and with high sensitivity and specificity. The large volume and high information content of the resulting image data, and the desire to obtain objective, quantitative descriptions and biophysical models of the processes of interest, require a high level of automation in data analysis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28323708/fenestrated-screws-augmented-with-pmma-increase-the-pullout-strength-of-sacral-pedicle-screws
#6
Matthew Colman, Jonathan Pond, Kent Bachus, Brandon D Lawrence, William R Spiker, Darrel S Brodke
STUDY DESIGN: Biomechanics. OBJECTIVE: The objective of this study was to compare the fixation in osteoporotic specimens of a bicortical sacral pedicle screw to the following constructs: a unicortical solid screw augmented with polymethylmethacrylate (PMMA) (TRACT), a unicortical fenestrated screw augmented with PMMA (FEN), and a bicortical screw/sacral alar screw combination (PED/ALA). SUMMARY OF BACKGROUND DATA: Rigid posterior sacral fixation of osteoporotic spines is problematic due to poor bone quality...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323704/minimizing-pedicle-screw-pullout-risks-a-detailed-biomechanical-analysis-of-screw-design-and-placement
#7
Rohan-Jean Bianco, Pierre-Jean Arnoux, Eric Wagnac, Jean-Marc Mac-Thiong, Carl-Éric Aubin
STUDY DESIGN: Detailed biomechanical analysis of the anchorage performance provided by different pedicle screw designs and placement strategies under pullout loading. OBJECTIVE: To biomechanically characterize the specific effects of surgeon-specific pedicle screw design parameters on anchorage performance using a finite element model. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation is commonly used in the treatment of spinal pathologies...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323642/a-bayesian-approach-for-three-dimensional-markerless-tumor-tracking-using-kv-imaging-during-lung-radiotherapy
#8
Chun-Chien Shieh, Vincent Caillet, Michelle Dunbar, Paul J Keall, Jeremy T Booth, Nicholas Hardcastle, Carol Haddad, Thomas Eade, Ilana Feain
The ability to monitor tumor motion without implanted markers can potentially enable broad access to more accurate and precise lung radiotherapy. A major challenge is that kilovoltage (kV) imaging based methods are rarely able to continuously track the tumor due to the inferior tumor visibility on 2D kV images. Another challenge is the estimation of 3D tumor position based on only 2D imaging information. The aim of this work is to address both challenges by proposing a Bayesian approach for markerless tumor tracking for the first time...
March 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28323583/pilots-attention-distributions-between-chasing-a-moving-target-and-a-stationary-target
#9
Wen-Chin Li, Chung-San Yu, Graham Braithwaite, Matthew Greaves
INTRODUCTION: Attention plays a central role in cognitive processing; ineffective attention may induce accidents in flight operations. The objective of the current research was to examine military pilots' attention distributions between chasing a moving target and a stationary target. METHOD: In the current research, 37 mission-ready F-16 pilots participated. Subjects' eye movements were collected by a portable head-mounted eye-tracker during tactical training in a flight simulator...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28323555/influence-of-dopamine-related-genes-on-neurobehavioral-recovery-after-traumatic-brain-injury-during-early-childhood
#10
Amery Treble-Barna, Shari L Wade, Lisa J Martin, Valentina Pilipenko, Keith Owen Yeates, H Gerry Taylor, Brad G Kurowski
The present study examined the association of dopamine-related genes with short- and long-term neurobehavioral recovery, as well as neurobehavioral recovery trajectories over time, in children who had sustained early childhood traumatic brain injuries (TBI) relative to children who had sustained orthopedic injuries (OI). Participants were recruited from a prospective, longitudinal study evaluating outcomes of children who sustained a TBI (n = 68) or OI (n = 72) between the ages of 3 and 7 years. Parents completed ratings of child executive function and behavior at the immediate post-acute period (0-3 months after injury); 6, 12, and 18 months after injury; and an average of 3...
March 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28323517/differences-in-adolescent-emotion-regulation-and-impulsivity-a-group-comparison-study-of-school-based-recovery-students
#11
Beth S Russell, Anne Thompson Heller, Morica Hutchison
BACKGROUND: Recovery high schools (RHS) vary in organization and operating philosophy, but are designed to support the unique needs of students struggling with substance use disorders (SUD). Previous research on youth risk taking behaviors suggests emotion regulation is a key predictor of outcomes. Specifically, the ability to respond in adaptive rather than maladaptive ways is often associated with challenges of impulsivity, poor distress tolerance, and adolescent substance use. OBJECTIVES: The current study considers data from RHS students in order to answer research questions concerning impulsivity and emotion regulation of youth working to change their risk trajectories in comparison to group of typically developing youth...
March 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28320056/health-related-quality-of-life-in-an-inception-cohort-of-children-with-juvenile-idiopathic-arthritis-a-longitudinal-analysis
#12
Kiem Oen, Jaime Guzman, Brenden Dufault, Lori B Tucker, Natalie J Shiff, Karen Watanabe Duffy, Jennifer J Y Lee, Brian M Feldman, Roberta A Berard, Paul Dancey, Adam M Huber, Rosie Scuccimarri, David A Cabral, Kimberly A Morishita, Suzanne E Ramsey, Alan M Rosenberg, Gilles Boire, Susanne M Benseler, Bianca Lang, Kristin Houghton, Paivi M Miettunen, Gaëlle Chédeville, Deborah M Levy, Alessandra Bruns, Heinrike Schmeling, Elie Haddad, Rae S M Yeung, Ciarán M Duffy
OBJECTIVES: To describe changes in health-related quality of life (HRQL) over time in children with juvenile idiopathic arthritis (JIA), relative to other outcomes; to identify predictors of unfavourable HRQL trajectories. METHODS: Children with JIA in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort were included. The Juvenile Arthritis Quality of Life Questionnaire (JAQQ, a standardized instrument), health-related Quality of My Life (HRQoML, an instrument based on personal valuations) and JIA core variables were completed serially...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28319851/-31-p-dephased-13-c-detected-redor-for-nmr-crystallography-at-natural-isotopic-abundance
#13
Alexander I Greenwood, Mary C Clay, Chad M Rienstra
Typically, the process of NMR-based structure determination relies on accurately measuring a large number of internuclear distances to serve as restraints for simulated annealing calculations. In solids, the rotational-echo double-resonance (REDOR) experiment is a widely used approach to determine heteronuclear dipolar couplings corresponding to distances usually in the range of 1.5-8Å. A challenge in the interpretation of REDOR data is the degeneracy of symmetric subunits in an oligomer or equivalent molecules in a crystal lattice, which produce REDOR trajectories that depend explicitly on two or more distances instead of one...
February 28, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28319757/interaction-driver-bicyclist-on-rural-roads-effects-of-cross-sections-and-road-geometric-elements
#14
Francesco Bella, Manuel Silvestri
The interaction of motorists and bicyclists, particularly during passing maneuvers, is cited as one of the primary causes of bicyclist fatalities. This paper reports the results of a driving simulator study, which sought to analyze the effects that three cross-section configurations of a two-lane rural road and four geometric elements of the road have on driver behavior, during the interaction with a cyclist. A two-lane rural road, about 11km long, was designed and implemented in an advanced-interactive driving simulator...
March 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28319752/energy-drink-use-frequency-among-an-international-sample-of-people-who-use-drugs-associations-with-other-substance-use-and-well-being
#15
Amy Peacock, Raimondo Bruno, Jason Ferris, Adam Winstock
OBJECTIVE: The study aims were to identify: i.) energy drink (ED), caffeine tablet, and caffeine intranasal spray use amongst a sample who report drug use, and ii.) the association between ED use frequency and demographic profile, drug use, hazardous drinking, and wellbeing. METHOD: Participants (n=74,864) who reported drug use completed the online 2014 Global Drug Survey. They provided data on demographics, ED use, and alcohol and drug use, completed the Alcohol Use Disorders Identification Test (AUDIT) and Personal Wellbeing Index (PWI), and reported whether they wished to reduce alcohol use...
February 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28319691/trajectories-of-maternal-depressive-symptoms-in-the-early-childhood-period-and-family-wide-clustering-of-risk
#16
Sheri Madigan, Mark Wade, André Plamondon, Jennifer M Jenkins
BACKGROUND: Previous research on individual differences in the course of maternal depressive symptoms has yielded inconsistent findings, with significant variation in the number and pattern of trajectories identified. In addition, missing from the literature is a comprehensive examination of predictors and longitudinal consequences of particular depression trajectories. METHOD: Participants in this study included a community cohort of 501 women assessed for depression using the Center for Epidemiologic Depression Scale at infant age 2, 18, 36, and 54 months...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28319562/translating-biomarkers-from-research-to-clinical-use-in-pediatric-neurocritical-care-focus-on-traumatic-brain-injury-and-cardiac-arrest
#17
Andrew J Prout, Michael S Wolf, Ericka L Fink
PURPOSE OF REVIEW: Traumatic brain injury (TBI) and cardiac arrest are important causes of morbidity and mortality in children. Improved diagnosis and outcome prognostication using validated biomarkers could allow clinicians to better tailor therapies for optimal efficacy. RECENT FINDINGS: Contemporary investigation has yielded plentiful biomarker candidates of central nervous system (CNS) injury, including macromolecules, genetic, inflammatory, oxidative, and metabolic biomarkers...
March 17, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28319256/cancer-in-adolescents-and-young-adults-who-remains-at-risk-of-poor-social-functioning-over-time
#18
Olga Husson, Bradley J Zebrack, Christine Aguilar, Brandon Hayes-Lattin, Steve Cole
BACKGROUND: The objective of the current study was to examine social functioning among adolescents and young adults (AYAs) within the first 2 years after a cancer diagnosis and compare their scores with population norms and identify trajectories of social functioning over time and its correlates. METHODS: A multicenter, longitudinal study was conducted among 215 AYA patients with cancer aged 14 to 39 years. A total of 141 patients completed a self-report measure of social functioning within the first 4 months of diagnosis and again at 12 months and 24 months later...
March 20, 2017: Cancer
https://www.readbyqxmd.com/read/28318797/early-symptom-trajectories-as-predictors-of-treatment-outcome-for-citalopram-versus-placebo
#19
Sigal Zilcha-Mano, Steven P Roose, Patrick J Brown, Bret R Rutherford
OBJECTIVES: The high percentage of failed clinical trials for anti-depressant medications, especially in elderly populations, obscures the fact that some patients may benefit greatly from treatment. Early detection of patients who may benefit most from antidepressant medication may improve treatment decisions. We examined whether depressed patients in a large clinical trial exhibit distinct trajectories of early symptom change that predict differential response to medication or placebo...
February 3, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28318473/the-developmental-trajectory-of-perceived-stress-mediates-the-relations-between-distress-tolerance-and-internalizing-symptoms-among-youth
#20
Julia W Felton, Anne N Banducci, Julia M Shadur, Ryan Stadnik, Laura MacPherson, Carl W Lejuez
The current study examines the relation between distress tolerance, perceived stress, and internalizing symptoms across adolescence. Participants included 331 youth, ages 10 to 14 at the first wave of the study, assessed annually over 5 years. A latent growth curve approach was used to test three research questions, including whether perceived stress would increase across adolescence, whether distress tolerance (as measured by a behavioral task) would predict changes in perceived stress, and whether changes in perceived stress would mediate the relation between distress tolerance and internalizing symptoms...
March 20, 2017: Development and Psychopathology
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