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https://www.readbyqxmd.com/read/27695261/high-performance-thin-layer-chromatography-method-development-validation-and-simultaneous-quantification-of-four-compounds-identified-in-standardized-extracts-of-orthosiphon-stamineus
#1
Suzana Hashim, Hooi Kheng Beh, Mohamad Shahrul Ridzuan Hamil, Zhari Ismail, Amin Malik Shah Abdul Majid
CONTEXT: Orthosiphon stamineus is a medicinal herb widely grown in Southeast Asia and tropical countries. It has been used traditionally as a diuretic, abdominal pain, kidney and bladder inflammation, gout, and hypertension. AIMS: This study aims to develop and validate the high-performance thin layer chromatography (HPTLC) method for quantification of rosmarinic acid (RA), 3'-hydroxy-5,6,7,4'-tetramethoxyflavone (TMF), sinensitin (SIN) and eupatorin (EUP) found in ethanol, 50% ethanol and water extract of O...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27619237/discovery-of-stable-non-opioid-dynorphin-a-analogues-interacting-at-the-bradykinin-receptors-for-the-treatment-of-neuropathic-pain
#2
Sara M Hall, Lindsay LeBaron, Cyf Ramos-Colon, Chaoling Qu, Jennifer Yanhua Xie, Frank Porreca, Josephine Lai, Yeon Sun Lee, Victor J Hruby
Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown that the neuroexcitatory effects are mediated through bradykinin (BK) receptors and that intrathecal (i.th.) administration of our lead ligand 1, [des-Arg(7)]-Dyn A-(4-11), which shows good binding affinity (IC50 = 150 nM) at the BK receptors, blocks Dyn A-induced hyperalgesia in naïve animals and reverses thermal and tactile hypersensitivities in a dose-dependent manner in nerve-injured animals...
September 27, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27261709/comparison-of-radiofrequency-targeted-vertebral-augmentation-with-balloon-kyphoplasty-for-the-treatment-of-vertebral-compression-fractures-2-year-results
#3
Rahel Bornemann, Tom R Jansen, Koroush Kabir, Peter H Pennekamp, Brit Stüwe, Dieter C Wirtz, Robert Pflugmacher
STUDY DESIGN: A retrospective study. OBJECTIVES: Evaluation of safety and effectiveness of radiofrequency-targeted vertebral, augmentation (RF-TVA) in comparison to balloon kyphoplasty (BK) for the treatment of, acute painful vertebral compression fractures (VCF) on the basis of matched pairs. SUMMARY OF BACKGROUND: Vertebroplasty and balloon kyphoplasty are the common surgical interventions for the, treatment of VCF. Both are effective and safe, but pose some risks such as adjacent, fractures and cement leakage...
June 3, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27241733/bk-channels-in-microglia-are-required-for-morphine-induced-hyperalgesia
#4
Yoshinori Hayashi, Saori Morinaga, Jing Zhang, Yasushi Satoh, Andrea L Meredith, Takahiro Nakata, Zhou Wu, Shinichi Kohsaka, Kazuhide Inoue, Hiroshi Nakanishi
Although morphine is a gold standard medication, long-term opioid use is associated with serious side effects, such as morphine-induced hyperalgesia (MIH) and anti-nociceptive tolerance. Microglia-to-neuron signalling is critically involved in pain hypersensitivity. However, molecules that control microglial cellular state under chronic morphine treatment remain unknown. Here we show that the microglia-specific subtype of Ca(2+)-activated K(+) (BK) channel is responsible for generation of MIH and anti-nociceptive tolerance...
2016: Nature Communications
https://www.readbyqxmd.com/read/27238267/bk-channels-in-the-central-nervous-system
#5
C Contet, S P Goulding, D A Kuljis, A L Barth
Large conductance Ca(2+)- and voltage-activated K(+) (BK) channels are widely distributed in the postnatal central nervous system (CNS). BK channels play a pleiotropic role in regulating the activity of brain and spinal cord neural circuits by providing a negative feedback mechanism for local increases in intracellular Ca(2+) concentrations. In neurons, they regulate the timing and duration of K(+) influx such that they can either increase or decrease firing depending on the cellular context, and they can suppress neurotransmitter release from presynaptic terminals...
2016: International Review of Neurobiology
https://www.readbyqxmd.com/read/26944020/inflammatory-mediator-bradykinin-increases-population-of-sensory-neurons-expressing-functional-t-type-ca-2-channels
#6
Dongyang Huang, Ce Liang, Fan Zhang, Hongchao Men, Xiaona Du, Nikita Gamper, Hailin Zhang
T-type Ca(2+) channels are important regulators of peripheral sensory neuron excitability. Accordingly, T-type Ca(2+) currents are often increased in various pathological pain conditions, such as inflammation or nerve injury. Here we investigated effects of inflammation on functional expression of T-type Ca(2+) channels in small-diameter cultured dorsal root ganglion (DRG) neurons. We found that overnight treatment of DRG cultures with a cocktail of inflammatory mediators bradykinin (BK), adenosine triphosphate (ATP), norepinephrine (NE) and prostaglandin E2 (PGE2) strongly increased the population size of the small-diameter neurons displaying low-voltage activated (LVA, T-type) Ca(2+) currents while having no effect on the peak LVA current amplitude...
April 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26612873/pharmacokinetics-and-safety-of-intravesicular-cidofovir-in-allogeneic-hsct-recipients
#7
Samuel L Aitken, Jian Zhou, Shashank S Ghantoji, Dimitrios P Kontoyiannis, Roy B Jones, Vincent H Tam, Roy F Chemaly
OBJECTIVES: The objective of this study was to evaluate the pharmacokinetics and safety of cidofovir administered via the intravesicular route to patients with haemorrhagic cystitis following allogeneic HSCT (allo-HSCT). METHODS: Patients with gross haematuria and confirmed BK or adenovirus viruria following allo-HSCT were prospectively enrolled in an open-label pharmacokinetic study (ClinicalTrials.gov registration: NCT01816646). Three hours after an oral probenecid dose (2 g), cidofovir (2...
March 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26607257/pharmacological-characterization-of-the-edema-caused-by-vitalius-dubius-theraphosidae-mygalomorphae-spider-venom-in-rats
#8
Thomaz A A Rocha-E-Silva, Alessandra Linardi, Edson Antunes, Stephen Hyslop
Bites by tarantulas (Theraphosidae, Mygalomorphae) in humans can result in mild clinical manifestations such as local pain, erythema, and edema. Vitalius dubius is a medium-sized, nonaggressive theraphosid found in southeastern Brazil. In this work, we investigated the mediators involved in the plasma extravasation caused by V. dubius venom in rats. The venom caused dose-dependent (0.1-100 μg/site) edema in rat dorsal skin. This edema was significantly inhibited by ((S)1-{2-[3(3-4-dichlorophenyl)-1-(3-iso-propoxyphenylacetyl)piperidine-3-yl]ethyl}-4-phenyl-1-azoniabicyclo[2...
January 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/26606297/corneal-tattooing-and-anterior-stromal-puncture-for-treating-symptomatic-bullous-keratopathy
#9
Hsin-Chiung Lin, Yi-Lun Wang, Guang-Wu Chen, Chieh-Hung Yen
PURPOSE: To investigate the efficacy of corneal tattooing, through anterior stromal puncture (ASP), for managing painful bullous keratopathy (BK). METHODS: This retrospective, case-controlled, consecutive case series study was performed at a university-based referral clinic. Patients with painful BK who underwent corneal tattooing with Chinese ink between 2007 and 2013 were included in analyses. Patients diagnosed with symptomatic BK who only underwent ASP during the same period were included as a control group...
March 2016: Cornea
https://www.readbyqxmd.com/read/26571430/update-on-urinary-tract-markers-in-interstitial-cystitis-bladder-pain-syndrome
#10
REVIEW
Bogdan Grigorescu, Kenneth Powers, George Lazarou
Interstitial cystitis (IC)/painful bladder syndrome/bladder pain syndrome (BPS) is a chronic hypersensory condition of unknown etiology. Moreover, the optimal modality for diagnosing IC remains disputed. Several urinary markers have been investigated that may have potential utility in the diagnosis or confirmation of IC/BPS. Thus, inflammatory mediators, proteoglycans, urinary hexosamines, proliferative factors, nitric oxide (NO), BK polyomavirus family, and urothelial proinflammatory gene analysis have been found to correlate with varying degrees with the clinical diagnosis or cystoscopic findings in patients with IC/BPS...
January 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/26491241/recurrent-rates-and-risk-factors-associated-with-recurrent-painful-bullous-keratopathy-after-primary-phototherapeutic-keratectomy
#11
Ngamjit Kasetsuwan, Kanokorn Sakpisuttivanit, Usanee Reinprayoon, Vilavun Puangsricharern
OBJECTIVE: To assess the recurrent rate, mean survival time, and risk factors associated with recurrent painful bullous keratopathy (BK) after primary treatment with phototherapeutic keratectomy. METHODS: Medical records from 72 patients (72 eyes) who had phototherapeutic keratectomy for painful BK were evaluated. Data for sex, age, duration of BK, associated ocular and systemic diseases (hypertension, diabetes mellitus, ischemic heart disease, asthma, dyslipidemia, and rheumatoid arthritis), frequency and degree of pain (grade 1-3), visual acuity, corneal thickness, intraocular pressure, and laser setting were extracted and analyzed...
2015: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26318494/a-possible-anti-inflammatory-mechanism-of-ethyl-acetate-extracts-of-teucrium-stocksianum-bioss
#12
Syed Muhammad Mukarram Shah
BACKGROUND: Teucrium stocksianum (T. stocksianum) is one of the important members of the genus Teucrium which contains numerous biologically active compounds. Traditionally, it is used for the treatment of fever, pain, as expectorant and blood purifier. Researchers are trying to discover plants origin, novel and safe remedies for the management of various ailments. The present study was aimed to determine the possible anti-inflammatory mechanism of ethyl acetate extract of T. stocksianum...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26311432/small-conductance-calcium-activated-potassium-sk-channels-in-the-amygdala-mediate-pain-inhibiting-effects-of-clinically-available-riluzole-in-a-rat-model-of-arthritis-pain
#13
Jeremy M Thompson, Guangchen Ji, Volker Neugebauer
BACKGROUND: Arthritis pain is an important healthcare issue with significant emotional and affective consequences. Here we focus on potentially beneficial effects of activating small-conductance calcium-activated potassium (SK) channels in the amygdala, a brain center of emotions that plays an important role in central pain modulation and processing. SK channels have been reported to regulate neuronal activity in the central amygdala (CeA, output nucleus). We tested the effects of riluzole, a clinically available drug for the treatment of amyotrophic lateral sclerosis, for the following reasons...
2015: Molecular Pain
https://www.readbyqxmd.com/read/26311398/hyaluronan-modulates-trpv1-channel-opening-reducing-peripheral-nociceptor-activity-and-pain
#14
Rebeca Caires, Enoch Luis, Francisco J Taberner, Gregorio Fernandez-Ballester, Antonio Ferrer-Montiel, Endre A Balazs, Ana Gomis, Carlos Belmonte, Elvira de la Peña
Hyaluronan (HA) is present in the extracellular matrix of all body tissues, including synovial fluid in joints, in which it behaves as a filter that buffers transmission of mechanical forces to nociceptor nerve endings thereby reducing pain. Using recombinant systems, mouse-cultured dorsal root ganglia (DRG) neurons and in vivo experiments, we found that HA also modulates polymodal transient receptor potential vanilloid subtype 1 (TRPV1) channels. HA diminishes heat, pH and capsaicin (CAP) responses, thus reducing the opening probability of the channel by stabilizing its closed state...
2015: Nature Communications
https://www.readbyqxmd.com/read/26297549/bioactive-peptides-derived-from-natural-proteins-with-respect-to-diversity-of-their-receptors-and-physiological-effects
#15
REVIEW
Masaaki Yoshikawa
We have found various bioactive peptides derived from animal and plant proteins, which interact with receptors for endogenous bioactive peptides such as opioids, neurotensin, complements C3a and C5a, oxytocin, and formyl peptides etc. Among them, rubiscolin, a δ opioid peptide derived from plant RuBisCO, showed memory-consolidating, anxiolytic-like, and food intake-modulating effects. Soymorphin, a μ opioid peptide derived from β-conglycinin showed anxiolytic-like, anorexigenic, hypoglycemic, and hypotriglyceridemic effects...
October 2015: Peptides
https://www.readbyqxmd.com/read/26267004/molecular-mechanisms-of-pain-in-crystal-induced-arthritis
#16
REVIEW
R Ramonda, F Oliviero, P Galozzi, P Frallonardo, M Lorenzin, A Ortolan, A Scanu, L Punzi
Crystal-induced arthritis (CIA) is characterized by an intense inflammatory reaction triggered by the deposition of monosodium urate, calcium pyrophosphate, and basic calcium phosphate crystals in articular and periarticular tissues. Severe, acute pain constitutes the most important clinical symptom in patients affected by these diseases. Pain along with redness, warmness, swelling, and stiffness in the affected joint arises abruptly in gout and disappears when the acute phase of the attack resolves. While an acute joint attack caused by calcium pyrophosphate crystals can mimic a gout flare, basic calcium phosphate crystal arthritis gives rise to a series of clinical manifestations, the most severe of which are calcific periarthritis, mostly asymptomatic, and a highly destructive arthritis known as Milwaukee shoulder syndrome, which is characterized by painful articular attacks...
February 2015: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/26234483/afferent-fibers-involved-in-the-bradykinin-induced-cardiovascular-reflexes-from-the-ovary-in-rats
#17
Sae Uchida, Fusako Kagitani, Harumi Hotta
Bleeding or rupture of the ovary often accompanies ovarian cysts and causes severe pain and autonomic responses such as hypotension. It would be expected that ovarian afferents contribute to cardiovascular responses induced by ovarian failure. The present study examined cardiovascular responses to noxious chemical stimulation of the ovary by bradykinin, an algesic substance released by tissue damage, and explored the role of ovarian afferents in the ovarian-cardiovascular responses in anesthetized rats. Non-pregnant adult rats were anesthetized with pentobarbital and artificially ventilated...
December 2015: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/26229319/ketamine-versus-magnesium-sulfate-with-caudal-bupivacaine-block-in-pediatric-inguinoscrotal-surgery-a-prospective-randomized-observer-blinded-study
#18
Waleed S H Farrag, Abdelrady S Ibrahim, Mostafa Galal Mostafa, Adel Kurkar, Ahmad A Elderwy
INTRODUCTION: Possible approaches for postoperative analgesia after pediatric inguinoscrotal surgery are caudal block by bupivacaine/ketamine (BK) and bupivacaine/magnesium sulfate (BM). AIM: The purpose of the following study is to compare the analgesic efficacy and safety of ketamine and magnesium sulfate in combination with bupivacaine for caudal blockade in pediatric patients after inguinoscrotal operations. MATERIALS AND METHODS: Patients randomly received one of the two solutions for caudal epidural injection after induction of general anesthesia...
July 2015: Urology Annals
https://www.readbyqxmd.com/read/26221618/blockade-of-non-opioid-excitatory-effects-of-spinal-dynorphin-a-at-bradykinin-receptors
#19
Yeon Sun Lee, Sara M Hall, Cyf Ramos-Colon, Michael Remesic, David Rankin, Todd W Vanderah, Frank Porreca, Josephine Lai, Victor J Hruby
Dynorphin A (Dyn A) is an endogenous opioid ligand that possesses neuroinhibitory (antinociceptive) effects via μ, δ, and κ opioid receptors. However, under chronic pain conditions, up-regulated spinal Dyn A can also interact with bradykinin receptors (BRs) to promote hyperalgesia through a neuroexcitatory(pronociceptive) effect. These excitatory effects cannot be blocked by an opioid antagonist, and thus are non-opioid in nature. On the basis of the structural dissimilarity between Dyn A and endogenous BR ligands, bradykinin(BK) and kallidin (KD), Dyn A's interaction with BRs could not be predicted, and provided an opportunity to identify a novel potential neuroexcitatory target...
2015: Receptors & Clinical Investigation
https://www.readbyqxmd.com/read/26157044/activation-of-mas-oncogene-related-g-protein-coupled-receptors-inhibits-neurochemical-alterations-in-the-spinal-dorsal-horn-and-dorsal-root-ganglia-associated-with-inflammatory-pain-in-rats
#20
Dongmei Wang, Peizhong Wang, Jianping Jiang, Qingqin Lv, Xueai Zeng, Yanguo Hong
Mas oncogene-related G protein-coupled receptor C (MrgC) is unequally expressed in sensory ganglia and has been shown to modulate pathologic pain. This study investigated the mechanism underlying the effect of MrgC receptors on inflammatory pain. Intrathecal administration of the selective MrgC receptor agonist bovine adrenal medulla 8-22 (BAM8-22) (30 nmol) inhibited complete Freund's adjuvant-evoked hyperalgesia. This was associated with the inhibition of protein kinase C-γ and phosphorylated extracellular signal-regulated protein kinase in the spinal cord and/or dorsal root ganglia (DRG)...
September 2015: Journal of Pharmacology and Experimental Therapeutics
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