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Barrett's esophagus

Xiaodun Li, Sam Kleeman, Sally B Coburn, Carlo Fumagalli, Juliane Perner, Sriganesh Jammula, Ruth M Pfeiffer, Linda Orzolek, Haiping Hao, Philip R Taylor, Ahmad Miremadi, Núria Galeano-Dalmau, Pierre Lao-Sirieix, Maria Tennyson, Shona MacRae, Michael B Cook, Rebecca C Fitzgerald
BACKGROUND & AIMS: MicroRNA (miRNA) is highly stable in biospecimens and provides tissue-specific profiles, making it a useful biomarker of carcinogenesis. We aimed to discover a set of miRNAs that could accurately discriminate Barrett's esophagus (BE) from normal esophageal tissue and to test its diagnostic accuracy when applied to samples collected by a non-invasive esophageal cell sampling device. METHODS: We analyzed miRNA expression profiles of 2 independent sets of esophageal biopsy tissues collected during endoscopy from 38 patients with BE and 26 patients with normal esophagus (controls) using Agilent microarray and Nanostring counter assays...
June 12, 2018: Gastroenterology
Ernst J Kuipers, Manon C Spaander
Barrett's esophagus (BE) is a very common condition. We have obtained fairly profound knowledge of the natural history of this condition. This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent to use their clinical data has improved our knowledge to the benefit of these same and other patients. The prevalence of BE increases with age both in men and in women. This increase starts at a younger age in men than in women. The incidence of high-grade dysplasia and cancer in BE depends on segment length, gender, and age...
June 15, 2018: Digestive Diseases and Sciences
Arvind J Trindade, Sumant Inamdar, Divyesh V Sejpal
No abstract text is available yet for this article.
September 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Mimi C Tan, Kavin A Kanthasamy, Allison G Yeh, Daniel Kil, Lisa Pompeii, Xiaoying Yu, Hashem B El-Serag, Aaron P Thrift
BACKGROUND & AIMS: Radiofrequency ablation (RFA) is effective treatment for Barrett's esophagus (BE). However, some patients have recurrence after complete eradication of intestinal metaplasia (CEIM). We investigated the incidence of and factors associated with BE recurrence, with or without neoplasia, after RFA and CEIM using data from the national Veterans Affairs (VA) healthcare system. METHODS: We performed a retrospective cohort study of Veterans with BE treated by RFA from 2005 through 2016 with follow-up endoscopy...
June 11, 2018: Clinical Gastroenterology and Hepatology
Maham Hayat, Sultan Mahmood, John T Maple
A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. An upper endoscopy performed at our medical center found multiple semi-pedunculated esophageal polyps between 18-24 cm from the incisors (Figure A)...
June 11, 2018: Clinical Gastroenterology and Hepatology
Tarek Sawas, Prasad G Iyer, Mouaz Alsawas, Cary C Cotton, Cadman L Leggett, M Hassan Murad, Kenneth K Wang, Nicholas J Shaheen, David A Katzka
BACKGROUND: Endoscopic eradication therapy (EET) is highly effective in treating dysplastic Barrett's esophagus (BE). Current surveillance intervals after complete remission of intestinal metaplasia (CRIM) are based on expert opinion. We performed a meta-analysis to compare BE detection in the first year to the subsequent ones METHODS: We searched MEDLINE, EMBASE, Scopus and Cochrane Central Register of Controlled Trials through 1 August 2017 for studies reporting IM and neoplasia detection after CRIM...
June 14, 2018: American Journal of Gastroenterology
Prasad G Iyer, William R Taylor, Michele L Johnson, Ramona L Lansing, Kristyn A Maixner, Tracy C Yab, Julie A Simonson, Mary E Devens, Seth W Slettedahl, Douglas W Mahoney, Calise K Berger, Patrick H Foote, Thomas C Smyrk, Kenneth K Wang, Herbert C Wolfsen, David A Ahlquist
BACKGROUND: Minimally invasive methods have been described to detect Barrett's esophagus (BE), but are limited by subjectivity and suboptimal accuracy. We identified methylated DNA markers (MDMs) for BE in tissue and assessed their accuracy on whole esophagus brushings and capsule sponge samples. METHODS: Step 1: Unbiased whole methylome sequencing was performed on DNA from BE and normal squamous esophagus (SE) tissue. Discriminant MDM candidates were validated on an independent patient cohort (62 BE cases, 30 controls) by quantitative methylation specific PCR (qMSP)...
June 12, 2018: American Journal of Gastroenterology
Seth A Gross, Michael S Smith, Vivek Kaul
Background: Barrett's esophagus (BE) and esophageal dysplasia (ED) are frequently missed during screening and surveillance esophagoscopy because of sampling error associated with four-quadrant random forceps biopsy (FB). Aim: The aim of this article is to determine if wide-area transepithelial sampling with three-dimensional computer-assisted analysis (WATS) used adjunctively with FB can increase the detection of BE and ED. Methods: In this multicenter prospective trial, patients screened for suspected BE and those with known BE undergoing surveillance were enrolled...
May 2018: United European Gastroenterology Journal
Zhensheng Wang, Nicholas J Shaheen, David C Whiteman, Lesley A Anderson, Thomas L Vaughan, Douglas A Corley, Hashem B El-Serag, Joel H Rubenstein, Aaron P Thrift
OBJECTIVES: Epidemiological studies of Helicobacter pylori infection and risk of Barrett's esophagus (BE) have reported conflicting results. We examined the association between H. pylori infection and BE and sought to determine whether the association is mediated by gastroesophageal reflux disease (GERD) and to identify potential effect modifiers. METHODS: We used individual level data from 1308 patients with BE (cases), 1388 population-based controls, and 1775 GERD controls in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)...
June 8, 2018: American Journal of Gastroenterology
Heather Klavan, Michael B Russell, Jared Macklin, Edwin Lee, Harry R Aslanian, Thiruvengadam Muniraj
No abstract text is available yet for this article.
June 4, 2018: Disease-a-month: DM
L C Duits, E Klaver, A Bureo Gonzalez, D F Boerwinkel, F J W Ten Kate, G J A Offerhaus, S L Meijer, M Visser, C A Seldenrijk, K K Krishnadath, E J Schoon, Bas L A M Weusten, Rosalie C Mallant-Hent, Roos E Pouw, Jacques J G H M Bergman
Patient selection is suboptimal in most studies focused on identifying biological markers for neoplastic progression in Barrett's esophagus (BE). This study aims to describe a stringently selected community-based case-control cohort of non-dysplastic BE (NDBE) patients who progressed to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) and BE patients who never progressed to be used for future biomarker studies. We identified all patients referred for endoscopic work-up of BE neoplasia at three tertiary referral centers for treatment of BE neoplasia between 2000 and 2013...
June 4, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Hala El-Zimaity, Vincenzo Di Pilato, Maria Novella Ringressi, Iva Brcic, Shanmugarajah Rajendra, Rupert Langer, Bastian Dislich, Monika Tripathi, Maha Guindi, Robert Riddell
Risk factors for esophageal cancer include genetic factors (such as tylosis) and infectious agents. A variety of organisms have been implicated in esophageal carcinogenesis, either directly or indirectly. In this review, we explore the normal esophageal flora and how it may be controlled, and also the variety of organisms that may affect esophageal carcinogenesis, either directly or indirectly. The organisms with potential direct effects in squamous cell carcinoma include human papillomavirus (HPV), Epstein-Barr virus, and polyoma viruses...
May 31, 2018: Annals of the New York Academy of Sciences
Hanan M Garalla, Nantaporn Lertkowit, Laszlo Tiszlavicz, Zita Reisz, Chris Holmberg, Rob Beynon, Deborah Simpson, Akos Varga, Jothi Dinesh Kumar, Steven Dodd, David Mark Pritchard, Andrew R Moore, András I Rosztóczy, Tibor Wittman, Alec Simpson, Graham J Dockray, Andrea Varro
Matrix metalloproteinase (MMP)-7, unlike many MMPs, is typically expressed in epithelial cells. It has been linked to epithelial responses to infection, injury, and tissue remodeling including the progression of a number of cancers. We have now examined how MMP-7 expression changes in the progression to esophageal adenocarcinoma (EAC), and have studied mechanisms regulating its expression and its functional significance. Immunohistochemistry revealed that MMP-7 was weakly expressed in normal squamous epithelium adjacent to EAC but was abundant in epithelial cells in both preneoplastic lesions of Barrett's esophagus and EAC particularly at the invasive front...
May 2018: Physiological Reports
Fatemeh G Amlashi, Xuemei Wang, Raquel E Davila, Dipen M Maru, Manoop S Bhutani, Jeffrey H Lee, Brian R Weston, Dilsa Mizrak Kaya, Maria Vassilakopoulou, Kazuto Harada, Mariela A Blum Murphy, David C Rice, Wayne L Hofstetter, Marta Davila, Quynh-Nhu Nguyen, Jaffer A Ajani
INTRODUCTION: Barrett's esophagus (BE) may be present in patients with esophageal adenocarcinoma (EAC) after bimodality therapy (BMT). There is no specific guidance for follow-up of these patients with regard to the presence of BE or dysplasia. In this study, we assessed the outcomes of patients who, after BMT, had BE and those who did not. METHOD: Patients with EAC who had BMT were identified and analyzed retrospectively in two groups, with and without BE. We compared patient characteristics and outcome variables (local, distant, and no recurrence)...
May 29, 2018: Oncology
Yash Choksi, Michael F Vaezi
Analysis of the esophageal microbiome remains a new field of research. Two hypothesis-generating papers published in the current issue of the Journal go beyond characterizing the esophageal microbiome in Barrett's esophagus or eosinophilic esophagitis (EoE). Snider et al. suggest that the salivary microbiome can be used as a screening tool for Barrett's esophagus, and Arias et al. demonstrates abnormal expression of Toll-like receptors and innate immune effector proteins in patients with active EoE. We discuss these findings, raise fundamental questions about microbiome studies, and offer ideas for future studies...
May 29, 2018: Clinical and Translational Gastroenterology
Marek Kollar, Julius Spicak, Eva Honsova, Jana Krajciova, Zuzana Vackova, Jan Martinek
Probe-based confocal laser endomicroscopy (pCLE) enables realtime histopathological assessment during endoscopic procedures to evaluate epithelial and subepithelial structures with a 1000x magnification. It may be used in various localizations not only in the digestive tract, but its role in clinical practice is still a matter of discussion. The main advantages of pCLE compared to standard biopsies may be: (1) realtime diagnosis, (2) which may be done by the endoscopist and (3) a larger evaluated area compared to standard biopsies...
May 25, 2018: Minerva Chirurgica
Jana Krajciova, Zuzana Vackova, Julius Spicak, Jan Martinek
Barrett's esophagus (BE) is a premalignant condition associated with increased risk of developing esophageal adenocarcinoma. In the past, BE patients with high-grade intraepithelial neoplasia (IEN) or early adenocarcinoma (EAC) were indicated for esophagectomy. With the recent advance in endoscopy, endoscopic techniques have surpassed esophagectomy in the treatment of Barrett's esophagus related neoplasia (BORN) and minimized the treatment-related morbidity. Patients with IEN are candidates for endoscopic treatment - endoscopic mucosal resection (ER) of visible lesions and/or ablation therapy of flat Barrett's mucosa...
May 25, 2018: Minerva Chirurgica
H Ece Arslan Ozcan, Turgut Anuk, Ozkan Ozden
PURPOSE: Barrett's esophagus is one of the main risk factors for increased incidence of esophageal adenocarcinoma. In this study, we studied protein expression levels and cellular localizations of MUC-1, MUC-2, MUC-5AC, CK7, and cytoplasmic p27 to assess the relationship between the expression of each of these proteins and the disease progression on endoscopic biopsies. MATERIALS AND METHODS: Immunohistochemical analyses were performed using antibodies produced against MUC-1, MUC-2, MUC-5AC, CK7, and p27...
May 23, 2018: Advances in Medical Sciences
D C Steinemann, P C Müller, A-C Schwarz, A Zerz, G R Linke, B P Müller-Stich
Laparoscopic transgastric stapler-assisted mucosectomy (SAM) has been described for minimally invasive circumferential en bloc resection of Barrett's esophagus (BE). Conceivably long-term disease control might be achieved by adding antireflux surgery after resection of BE by SAM. The aim of this study was to assess the feasibility of combined SAM and fundoplication in one laparoscopic procedure in six pigs. Furthermore, the competence of the gastroesophageal junction (GEJ) was assessed at baseline, after SAM, and after subsequent laparoscopic fundoplication...
May 21, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Yun-Cang Wang, Zhi-Qiang Wang, Yong Yuan, Tao Ren, Peng-Zhi Ni, Long-Qi Chen
Objective: To explore the role of Notch signaling in the development of Barrett's esophagus. Methods: Patients with esophagectomy and gastric interposition were recruited as a human model of gastroesophageal reflux disease. The expressions of Notch signaling genes in normal esophagus from surgical specimen and columnar metaplasia in the esophageal remnant after esophagectomy were evaluated by real time quantitative Polymerase Chain Reaction (RT-qPCR) and immunohistochemistry (IHC)...
2018: Canadian Journal of Gastroenterology & Hepatology
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