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Urothelial cancer

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https://www.readbyqxmd.com/read/29777711/uca1-confers-paclitaxel-resistance-to-ovarian-cancer-through-mir-129-abcb1-axis
#1
Junrong Wang, Cong Ye, Junbao Liu, Yubo Hu
Increasing evidence has demonstrated the involvement of dysregulated long non-coding RNAs (lncRNAs) in chemoresistance acting as potential oncogenes or tumor suppressors in various cancers. Nevertheless, the profound molecular mechanisms of lncRNAs in ovarian cancer (OC) chemoresistance is not well elucidated. The objective of this work was to investigate the role and molecular mechanisms of urothelial carcinoma associated 1 (UCA1) in paclitaxel (PTX) resistance in OC. Our results indicated that UCA1 was significantly up-regulated in PTX-resistant OC cells (SKOV3/PTX and HeyA-8/PTX) compared with their parental cells (SKOV3 and HeyA-8)...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29776013/prognostic-pathologic-factors-in-radical-cystectomy-after-neoadjuvant-chemotherapy
#2
Fadi Brimo, Michelle R Downes, Tamara Jamaspishvili, David Berman, Guliz A Barkan, Daniel Athanazio, Schuharazad Abro, Kash Visram, Asli Yilmaz, Shraddha Solanki, Elan Hahn, Robert Siemens, Wassim Kassouf, Kiril Trpkov
We undertook a systematic evaluation of the prognostic value of numerous histologic factors in 165 radical cystectomies (RC) of patients with invasive urothelial carcinoma who underwent surgery after neoadjuvant chemotherapy (NAC). Tumor regression grade (TRG) and therapy-related stromal and epithelial changes were also recorded. Locally advanced disease (≥pT2 and/or pN+) was present in 64% of patients, 22% had no evidence of residual carcinoma (pT0+pN0) and 28% had no evidence of residual muscle invasive carcinoma (≤pT1+N0)...
May 18, 2018: Histopathology
https://www.readbyqxmd.com/read/29772615/-a-case-of-renal-pelvic-cancer-with-acquired-hemophilia-and-leukemoid-reaction
#3
Daiki Ikarashi, So Omori, Wataru Izumida, Yasuyuki Nakamura, Masakazu Abe, Takashi Ujiie, Wataru Obara
A 71-year-old man was referred to us with a right renal mass that was discovered by computed tomography (CT) examination for acquired hemophilia and leukemoid reaction. He presented with persistent low-grade fever and purpura on the lower legs caused by acquired hemophilia. Contrastenhanced CT scan showed a right renal tumor 6.0×7.4 cm in diameterwith inhomogeneous enhancement. The result of his urine cytology was negative. After improvement of his coagulation by treatment with immunosuppressants and steroids, he underwent open nephrectomy...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29767328/a-placebo-controlled-efficacy-study-of-the-intravesical-immunomodulators-tmx-101-and-tmx-202-in-an-orthotopic-bladder-cancer-rat-model
#4
Johannes Falke, Christina A Hulsbergen-van de Kaa, Roberto Maj, Egbert Oosterwijk, J Alfred Witjes
PURPOSE: TMX-101 and TMX-202 are formulations of toll-like receptor 7 (TLR-7) agonists, under investigation for the treatment of urothelial carcinoma. Our goal was to evaluate the efficacy of intravesical instillations of TMX-101 or TMX-202 in an orthotopic bladder cancer rat model. METHODS: Four groups of 14 rats received an instillation with isogenic AY-27 tumor cells on day 0, starting tumor development. On day 2 and 5, the rats were treated with an intravesical instillation of TMX-101 0...
May 16, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29765141/polyoma-virus-associated-carcinomas-of-the-urologic-tract-a-clinicopathologic-and-molecular-study
#5
Deepika Sirohi, Charlie Vaske, Zack Sanborn, Steven C Smith, Michelle D Don, Kathryn G Lindsey, Scot Federman, Mahesha Vankalakunti, Jamie Koo, Shikha Bose, Mariza de Peralta-Venturina, Jessica van Ziffle, James P Grenert, Steve Miller, Charles Chiu, Mahul B Amin, Jeffry P Simko, Bradley A Stohr, Daniel J Luthringer
In recent years, there has been increased interest in carcinomas of the urologic tract, that demonstrate association with the polyoma virus BK arising in immunosuppressed individuals, though the nature of this association is uncertain. To begin to understand this phenomenon, we reviewed the clinical, morphological, and immunohistochemical features of 11 carcinomas of the urologic tract, mainly urothelial (N = 9) and collecting duct carcinomas (N = 2), occurring during immunosuppression, and expressing polyoma virus T-antigen by immunohistochemistry...
May 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29764095/clinical-outcomes-in-a-cohort-of-patients-with-t1-high-grade-urothelial-bladder-cancer-not-receiving-intravesical-bacillus-calmette-guerin-a-15-year-experience
#6
S A S Goonewardena, U Jayarajah, S N Kuruppu, H M K B Herath, D M H Fernando, K Vickneswaran
No abstract text is available yet for this article.
March 31, 2018: Ceylon Medical Journal
https://www.readbyqxmd.com/read/29763719/small-cell-carcinoma-of-the-urinary-bladder-a-clinicopathologic-and-immunohistochemical-analysis-of-81-cases
#7
Gang Wang, Li Xiao, Miao Zhang, Ashish M Kamat, Arlene Siefker-Radtke, Colin P Dinney, Bogdan Czerniak, Charles C Guo
Small cell carcinoma (SmCC) of the bladder is a rare disease. We retrospectively studied a large series of bladder SmCC from a single institution. The patients included 69 men and 12 women with a mean age of 68years. Most bladder SmCC were presented at advanced stage with tumors invading the muscularis propria and beyond (n=77). SmCC was pure in 27 cases and mixed with other histologic types in 54 cases, including urothelial carcinoma (UC) (n=32), UC in situ (n=26), glandular (n=14), micropapillary (n=4), sarcomatoid (n=4), and squamous (n=3), and plasmacytoid (n=1) features...
May 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29762827/upregulation-of-long-non-coding-rna-hnf1a-as1-is-associated-with-poor-prognosis-in-urothelial-carcinoma-of-the-bladder
#8
Y-H Wang, Y-H Liu, Y-J Ji, Q Wei, T-B Gao
OBJECTIVE: Long noncoding RNAs (lncRNAs) play important roles in the pathogenesis of bladder cancer. A recent study reported that lncRNA HNF1A-AS1 (HNF1A-AS1) was upregulated in urothelial carcinoma of the bladder (UCB) and served as a tumor promoter. However, the clinical significance of HNF1A-AS1 in the prognosis of patients with UCB was poorly understood. This work was designed to investigate the relationship between HNF1A-AS1 expression level and the prognosis of UCB. PATIENTS AND METHODS: Relative expression levels of HNF1A-AS1 in UCB tissues were determined by qRT-PCR...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29762824/long-noncoding-rna-uca1-promotes-cell-proliferation-migration-and-invasion-of-human-leukemia-cells-via-sponging-mir-126
#9
M-D Sun, Y-Q Zheng, L-P Wang, H-T Zhao, S Yang
OBJECTIVE: Acute myeloid leukemia (AML) is a bone marrow malignancy. Long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) plays an important role in several cancers. However, the role of lncRNA UCA1 in AML remained unclear. MATERIALS AND METHODS: LncRNA UCA1 expressions in different cell lines were determined by RT-PCR. In human myelogenous leukemia (ML) cell lines K562 and HL60, effects of lncRNA UCA1 knockdown on cell viability, migration, invasion, and apoptosis were assessed, respectively...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29761225/pathological-characteristics-and-prognostic-indicators-of-different-histopathological-types-of-urinary-bladder-cancer-following-radical-cystectomy-in-a-large-single-center-egyptian-cohort
#10
Jeremy W Martin, Simone L Vernez, Yair Lotan, Ahmed Abdelhalim, Rahul Dutta, Ahmed Shokeir, Hassan Abol-Enein, Ahmed Mosbah, Mohamed Ghoneim, Ramy F Youssef
OBJECTIVE: To evaluate differences in pathological features and prognostics across four bladder cancer histopathological types: urothelial carcinoma (UC), urothelial carcinoma with variant histology (UCV), squamous cell carcinoma (SCC) and adenocarcinoma (ADC), utilizing a large cohort of radical cystectomy (RC) patients. METHODS: A retrospective analysis of patients who underwent RC at a single institution in Egypt between 1997 and 2004 was performed. Kaplan-Meier and multivariable analyses were performed to evaluate the prognostic significance of pathological features including tumor stage, grade, lymphovascular invasion (LVI), and lymph node (LN) involvement in the different subtypes on disease-free survival (DFS)...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29757570/incidence-and-treatment-of-malignant-tumors-of-the-genitourinary-tract-in-renal-transplant-recipients
#11
Juan Manuel Ochoa-López, Bernardo Gabilondo-Pliego, Sylvain Collura-Merlier, Jaime O Herrera-Cáceres, Mariano Sotomayor de Zavaleta, Francisco Tomás Rodríguez-Covarrubias, Guillermo Feria-Bernal, Fernando Gabilondo-Navarro, Ricardo Alonso Castillejos-Molina
PURPOSE: To provide data of the incidence and management of common urological malignancies in renal transplant recipients. MATERIALS AND METHODS: We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A descriptive analysis of the sample was performed. RESULTS: Among 1256 consecutive RTR a total of 88 patients developed malignancies (7%). There were 18 genitourinary tumors in the 16 patients (20.45% of all malignant neoplasms), incidence of 1...
April 30, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29757495/a-20-year-and-46-000-specimen-journey-to-paris-reveals-the-influence-of-reporting-systems-and-passive-peer-feedback-on-pathologist-practice-patterns
#12
Christopher J VandenBussche, Derek B Allison, Mohit Gupta, Syed Z Ali, Dorothy L Rosenthal
BACKGROUND: An important goal of The Paris System for Reporting Urinary Cytology (TPS) is to reduce unnecessary atypical diagnoses given to urinary tract cytology (UTC) specimens. Since implementation of TPS at the study institution in 2016, the institutional atypical rate has declined only slightly. The authors speculated that TPS might not have had an immediate impact because several faculty members were involved in TPS committees and because TPS contains elements that already had been integrated into institutional practice...
May 14, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29752514/overall-survival-in-patients-with-residual-disease-after-radical-cystectomy-and-neoadjuvant-chemotherapy
#13
Izak Faiena, Amirali Salmasi, Neil Mendhiratta, Andrew T Lenis, Aydin Pooli, Alexandra Drakaki, Kiran Gollapudi, Jeremy Blumberg, Allan J Pantuck, Karim Chamie
BACKGROUND: Neoadjuvant chemotherapy (NAC) has been shown to improve survival in patients with urothelial carcinoma (UC). However, there are a subset of patients who do not respond or progress despite systemic treatment. METHODS: Data from the National Cancer Database on patients who underwent a radical cystectomy (RC) with or without NAC from 2006 to 2013 were abstracted. Covariates were balanced using inverse probability weighting methods. The primary outcome of overall survival in patients with residual disease by stage was evaluated using 90-day conditional landmark analysis and Cox proportional hazards modeling...
May 11, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29750666/pd-l1-immunohistochemistry-assay-concordance-in-urothelial-carcinoma-of-the-bladder-and-hypopharyngeal-squamous-cell-carcinoma
#14
Anjelica Hodgson, Elzbieta Slodkowska, Achim Jungbluth, Stanley K Liu, Danny Vesprini, Danny Enepekides, Kevin Higgins, Nora Katabi, Bin Xu, Michelle R Downes
Programmed death ligand-1 (PD-L1) immunohistochemistry is used to guide treatment decisions regarding the use of checkpoint immunotherapy in the management of urothelial carcinoma of the bladder and hypopharyngeal (HP) squamous cell carcinoma. With increasing PD-L1 testing options, a need has arisen to assess the analytical comparability of diagnostic assays in order to develop a more sustainable testing strategy. Using tissue microarrays, PD-L1 expression in tumor cells (TCs) and immune cells (ICs) was manually scored in 197 cases and 27 cases of bladder and HP cancer, respectively...
May 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29748795/role-of-lncrnas-as-prognostic-markers-of-hepatic-cancer-and-potential-therapeutic-targeting-by-s-adenosylmethionine-via-inhibiting-pi3k-akt-signaling-pathways
#15
Kadry M Sadek, Mohamed A Lebda, Nasr E Nasr, Sherif M Nasr, Yasser El-Sayed
Hepatic cancer (HCC) is a well-identified dilemma throughout the world, and hence, the molecular mechanisms and strategy for preventive protection against this malignancy are critical. S-adenosylmethionine (SAM) is a unique methyl granter in vast reactions, including DNA methylation, and secures the genome against hypomethylation, which is a hallmark of tumors. Consequently, SAM may control the rate of gene expression. The objective of this investigation was to evaluate the expression of long noncoding RNAs (lncRNAs) transcript involved in hepatic tumorigenesis, including additional coding CEBPA (ecCEBPA) and urothelial carcinoma related 1 (UCA1), antioxidant enzymes transcripts, and relevant signaling pathway in diethylnitrosamine (DEN)-prompted HCC along with their conceivable targeting by SAM at different stages of HCC in rats...
May 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29748589/prognostic-impact-of-tumor-infiltrating-lymphocytes-on-patients-with-metastatic-urothelial-carcinoma-receiving-platinum-based-chemotherapy
#16
Hui-Shan Huang, Harvey Yu-Li Su, Pei-Hsu Li, Po-Hui Chiang, Cheng-Hua Huang, Chien-Hsu Chen, Meng-Che Hsieh
The impact of tumor infiltrating lymphocytes (TILs) on survival was confirmed in various cancer types. Our study aims to investigate the prognostic role of TILs on survival in patients with metastatic urothelial carcinoma (mUC) receiving platinum based chemotherapy. Patients who were diagnosed to have pathologically proved mUC between 1997 and 2016 and received palliative chemotherapy with platinum based regimen were recruited into our study. Kaplan-Meier curves and Cox regression analysis were constructed for overall survival (OS)...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29748098/multi-institutional-evaluation-of-the-prognostic-significance-of-ezh2-expression-in-high-grade-upper-tract-urothelial-carcinoma
#17
Nirmish Singla, Laura-Maria Krabbe, Ahmet M Aydin, Vandana Panwar, Solomon L Woldu, Yuval Freifeld, Christopher G Wood, Jose A Karam, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan, Aditya Bagrodia, Payal Kapur, Vitaly Margulis
PURPOSE: Enhancer of zeste homolog 2 is a methyltransferase encoded by the EZH2 gene, whose role in upper tract urothelial carcinoma (UTUC) is poorly understood. We sought to evaluate the prognostic value of EZH2 expression in UTUC. METHODS: We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy for high-grade UTUC from 1990 to 2008. Immunohistochemistry for EZH2 was performed on tissue microarrays. Percentage of staining was evaluated, and the discriminative value of EZH2 was tested, with EZH2 positivity defined as>20% staining present...
May 7, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29747777/mir-429-expression-in-bladder-cancer-and-its-correlation-with-tumor-behavior-and-clinical-outcome
#18
Chia-Lun Wu, Jar-Yi Ho, Shun-Hsing Hung, Dah-Shyong Yu
We previously showed that microRNA-429 (miR-429) played an important role in epithelial-mesenchymal transition (EMT) of urothelial cell carcinoma of the bladder. We herein evaluated the expression of miR-429 in bladder cancer and its potential relevance to clinicopathological characteristics and patient survival. Relative expression levels of miR-429 in surgical bladder cancer tissue specimens obtained from 76 patients with bladder cancer were measured by chromogenic in situ hybridization. miR-429 expression was significantly higher in specimens from alive patients than expired patients in both of 5-year overall survival (OS) (0...
June 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29745927/-new-endovesical-chemotherapy-drugs-and-application-vehicles
#19
Emilio Rios González, Luis Martínez-Piñeiro
Urothelial bladder cancer is a very prevalent disease. At the time of diagnosis 70-80% of the cases present as non muscle invasive tumors. These tumors present a high recurrence and progression rates despite intravesical treatment with Bacille Calmette-Guerin and mitomycin C. Moreover, bladder conditions such as its wall impermeability and the fact that intravesical drugs are constantly being diluted by urine and eliminated do not favor the efficacy of intravesical treatment. This review analyzes new intravesical drugs such as gemcitabine or taxanes with promising results as alternative to the usual treatments or after their failure...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745925/-mechanism-of-action-of-intravesical-bcg-biological-bases-and-clinical-applicability
#20
Joaquín A Carballido, María Rodríguez Monsalve
The therapeutic approaches developed around immune system modulation find the therapeutic contribution of intravesical Bacillus Calmette Guerin (BCG) for transitional cell bladder cancer an unquestionable example as a proof of concept of antitumor immunotherapy since more than 30 years ago. Intravesical immunotherapy for urothelial carcinomas is considered with periodic intravesical instillations schedules, and the one with longer historic development and wider diffusion is BCG in the form of suspension. BCG is a unique strain obtained from Mycobacterium bovis at the end of the first third of the XX century and represents the historically most successful immunotherapeutic modality of all tumors with a high level body of evidence...
May 2018: Archivos Españoles de Urología
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