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Urothelial cancer

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https://www.readbyqxmd.com/read/28212060/pembrolizumab-as-second-line-therapy-for-advanced-urothelial-carcinoma
#1
Joaquim Bellmunt, Ronald de Wit, David J Vaughn, Yves Fradet, Jae-Lyun Lee, Lawrence Fong, Nicholas J Vogelzang, Miguel A Climent, Daniel P Petrylak, Toni K Choueiri, Andrea Necchi, Winald Gerritsen, Howard Gurney, David I Quinn, Stéphane Culine, Cora N Sternberg, Yabing Mai, Christian H Poehlein, Rodolfo F Perini, Dean F Bajorin
Background Patients with advanced urothelial carcinoma that progresses after platinum-based chemotherapy have a poor prognosis and limited treatment options. Methods In this open-label, international, phase 3 trial, we randomly assigned 542 patients with advanced urothelial cancer that recurred or progressed after platinum-based chemotherapy to receive pembrolizumab (a highly selective, humanized monoclonal IgG4κ isotype antibody against programmed death 1 [PD-1]) at a dose of 200 mg every 3 weeks or the investigator's choice of chemotherapy with paclitaxel, docetaxel, or vinflunine...
February 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28210516/immunohistochemical-investigation-of-her-akt-mtor-pathway-and-cellular-adhesion-molecules-in-urothelial-carcinomas
#2
Nikolaos Koletsas, Triantafyllia Koletsa, Spyros Choidas, Konstantinos Anagnostopoulos, Stavros Touloupidis, Thomas Zaramboukas, Georgia Raptou, Nikolaos Papadopoulos, Maria Lambropoulou
Background. Several investigators have suggested the possibility that the expression of both EGFR and HER2 could be utilized for molecularly targeted therapy in urinary bladder cancer. We tried to evaluate the expression of HER2 and EGFR and activation of the AKT/PTEN/mTOR pathway in urothelial carcinomas and if there is any association between them and cellular adhesion molecules (CAMs). Materials and Methods. Forty-one paraffin-embedded urothelial cancer tissue blocks were collected. Immunostains for HER2, EGFR, MIB1, phospho-AKT, PTEN, phospho-mTOR, e-cadherin, p-cadherin, and b-catenin were performed on tissue microarrays sections...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28207636/association-between-pretransplant-cancer-and-survival-in-kidney-transplant-recipients
#3
Dag Olav Dahle, Tom Grotmol, Torbjørn Leivestad, Anders Hartmann, Karsten Midtvedt, Anna V Reisæter, Geir Mjøen, Hege K Pihlstrøm, Hege Næss, Hallvard Holdaas
BACKGROUND: Kidney transplantation in recipients with a previous malignancy is often deferred 2-5 years after cancer treatment due to fear of cancer recurrence. In Norway, the required waiting period has been 1 year. METHODS: We compared patient and graft survival of recipients with pretransplant cancer to the outcomes of matched recipients without such cancer (comparators) using Cox regression. RESULTS: From 1963 to 2010, 377 of 5867 recipients (6...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28207504/unusual-presentation-of-direct-intraperitoneal-metastases-complicated-with-massive-ascites-from-plasmacytoid-variant-of-bladder-cancer-and-adenocarcinoma-of-colon-a-case-report-and-literature-review
#4
Yu-Hua Shao, Chien-Chang Kao, Shou-Hung Tang, Tai-Lung Cha, Chih-Wei Tsao, En Meng, Dah-Shyong Yu, Guang-Huan Sun, Sheng-Tang Wu
BACKGROUND: Plasmacytoid urothelial carcinoma (PUC) is a distinct variant of urinary bladder cancer, with a high propensity for invasion and poor prognosis. These tumors occur most commonly in male patients with the age of reported cases ranging from 46 to 87 years. CASE REPORT: We present a case of a 74-year-old male patient having massive ascites and bilateral lower leg edema. Colonoscopy showed a 3-cm lesion in the sigmoid colon and an edematous nonpapillary tumor was found by cystoscopy in the bladder...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28203296/incorporating-vegf-targeted-therapy-in-advanced-urothelial-cancer
#5
REVIEW
Sujata Narayanan, Sandy Srinivas
Patients with relapsed or refractory urothelial carcinoma (UC) have poor prognosis coupled with few options for systemic treatment. The role of angiogenesis in the evolution of cancers has been established, and studies have shown that it plays a key role in the pathogenesis of UC. Many targeted agents have been used in phase I-II trials for the treatment of UC, with encouraging but modest results. Recently, studies combining angiogenesis inhibitors with other chemotherapeutic agents were able to achieve objective responses higher than most commonly used second-line therapies in UC...
January 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/28198599/impact-of-a-bladder-cuff-excision-during-radical-nephroureterectomy-on-cancer-specific-survival-in-the-patients-with-upper-tract-urothelial-cancer-in-korea-a-retrospective-multi-institutional-study
#6
Yun-Sok Ha, Jae-Wook Chung, Seock H Choi, Jun N Lee, Bum S Kim, Tae-Hwan Kim, Eun S Yoo, Tae G Kwon, Seok-Soo Byun, Young D Choi, Ho W Kang, Seok J Yun, Wun-Jae Kim, Hyun T Kim
BACKGROUND: Radical nephroureterectomy (RNU) with bladder cuff excision (BCE) is the surgical principle adopted for the treatment of upper tract urothelial cancers (UTUCs). However, not all RNUs are performed with BCE. We quantified the prognostic impact of RNU with BCE on cancer-specific survival (CSS) in a large patient population. METHODS: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathological parameters of patients who underwent RNU with and without BCE were compared...
February 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28197393/preclinical-efficacy-and-safety-of-the-ty21a-vaccine-strain-for-intravesical-immunotherapy-of-non-muscle-invasive-bladder-cancer
#7
Sonia Domingos-Pereira, Valérie Cesson, Mathieu F Chevalier, Laurent Derré, Patrice Jichlinski, Denise Nardelli-Haefliger
Intravesical Bacillus-Calmette-Guérin (BCG) immunotherapy can reduce recurrence/progression of non-muscle-invasive bladder cancer (NMIBC), although significant adverse events and treatment failure argue for alternative options. Here, we examined whether another attenuated live vaccine, Vivotif/Ty21a, used since more than 30 y against typhoid fever, may be safely used intravesically to improve bladder-tumor treatment. Mice-bearing MB49 orthotopic bladder-tumors treated with intravesical Ty21a or BCG were compared for survival and bacteria recovery...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28195647/molecular-classification-of-urothelial-carcinoma-global-mrna-classification-versus-tumour-cell-phenotype-classification
#8
Gottfrid Sjödahl, Pontus Eriksson, Fredrik Liedberg, Mattias Höglund
Global mRNA expression analysis is efficient for phenotypic profiling of tumours and has been used to define molecular subtypes for almost every major tumour type. A key limitation is that most tumours are communities of both tumour and non-tumour cells. This problem is particularly pertinent when analysing advanced invasive tumours, known to induce major changes and responses in both the tumour and the surrounding tissue. To identify bladder cancer tumour-cell phenotypes and compare classification by tumour-cell phenotype with classification by global gene expression analysis, we analysed 307 advanced bladder cancers (cystectomised) both by genome gene expression analysis and by immunohistochemistry using antibodies for 28 proteins...
February 13, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28193625/deep-sequencing-of-urinary-rnas-for-bladder-cancer-molecular-diagnostics
#9
Mandy L Y Sin, Kathleen E Mach, Rahul Sinha, Fan Wu, Dharati Trivedi, Emanuela Altobelli, Kristin C Jensen, Debashis Sahoo, Ying Lu, Joseph C Liao
PURPOSE: The majority of bladder cancer patients present with localized disease and are managed by transurethral resection. However, the high rate of recurrence necessitates lifetime cystoscopic surveillance. Developing a sensitive and specific urine-based test would significantly improve bladder cancer screening, detection, and surveillance. EXPERIMENTAL DESIGN: RNA-seq was used for biomarker discovery to directly assess the gene expression profile of exfoliated urothelial cells in urine derived from bladder cancer patients (n=13) and controls (n=10)...
February 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28188048/prognostic-value-of-leptin-receptor-overexpression-in-upper-tract-urothelial-carcinomas-in-taiwan
#10
Yi-Chen Lee, Wen-Jeng Wu, Hui-Hui Lin, Wei-Ming Li, Chun-Nung Huang, Wei-Chi Hsu, Lin-Li Chang, Ching-Chia Li, Hsin-Chih Yeh, Chien-Feng Li, Hung-Lung Ke
OBJECTIVES: Leptin and its receptor (LEPR) are key players in the regulation of energy balance and body weight control and act as a growth factor for specific organs in both normal and disease states. However, LEPR accumulation may be involved in carcinogenesis, progression, and metastasis in many cancers. This study evaluated the clinical significance of LEPR expression in upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: LEPR expression was examined in 110 tissue samples from patients with UTUC, using immunohistochemistry, and an analysis was performed to identify evidence of association between LEPR expression and different clinicopathologic variables...
January 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28185084/-schistosomose-urog%C3%A3-nitale-et-cancer
#11
A Berry, X Iriart, J Fillaux, J-F Magnaval
The existence of a link between urinary schistosomiasis (US) and bladder carcinoma was first suspected by C. Goebel in 1905. In 1911, A.R Ferguson, who was a professor of Pathology and Microbiology at the Faculty of Medicine in Cairo, published a more detailed survey from 40 autopsies, and reported a likely association of bladder carcinoma with granulomas caused by US. Subsequently, published results from several studies reinforced Ferguson's hypothesis. Moreover, in most countries where US was endemic, association of high prevalence of bladder carcinoma with US had been pointed out...
February 10, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28183696/nivolumab-gets-fda-nod-for-bladder-cancer
#12
(no author information available yet)
The FDA has granted accelerated approval to nivolumab for patients with locally advanced or metastatic urothelial carcinoma whose disease has progressed on platinum chemotherapy. This is the second PD-1-targeting agent in less than a year to get the agency's nod for bladder cancer.
February 9, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28182725/prognostic-implications-of-preoperative-anemia-in-urothelial-carcinoma-a-meta-analysis
#13
Fei Luo, Ya-Shen Wang, Yan-Hui Su, Zhi-Hua Zhang, Hong-Hong Sun, Jian Li
The prognostic significance of preoperative anemia (PA) has been identified in various malignancies. However, its predictive role in urothelial carcinoma (UC) remains controversial. The aim of this study was to investigate the prognostic value of PA in UC patients. We performed a meta-analysis of the association between PA and survival outcome in UC patients. Electronic databases were searched up to June 30, 2016. Study characteristics and prognostic data were extracted from each included study. Cancer-specific survival (CSS), recurrence-free survival (RFS), and overall survival (OS) were pooled using hazard ratio (HR) with corresponding 95% confidence intervals (CI)...
2017: PloS One
https://www.readbyqxmd.com/read/28182321/detection-and-oncological-effect-of-circulating-tumour-cells-in-patients-with-variant-urothelial-carcinoma-histology-treated-with-radical-cystectomy
#14
Armin Soave, Sabine Riethdorf, Roland Dahlem, Sarah Minner, Lars Weisbach, Oliver Engel, Margit Fisch, Klaus Pantel, Michael Rink
OBJECTIVES: To investigate for the presence of circulating tumour cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes. PATIENTS AND METHODS: We prospectively collected data of 188 patients with UCB treated with RC without neoadjuvant chemotherapy. Pathological specimens were meticulously reviewed for pure and variant UCB histology. Preoperatively collected blood samples (7...
February 9, 2017: BJU International
https://www.readbyqxmd.com/read/28179333/liver-metastasis-of-urothelial-carcinoma-with-hepatoid-features-an-unusual-morphological-finding
#15
Paul Friedman, Jin-Ping Lai
Bladder cancer comprises of many well-known variants and divergent histologies, both of urothelial and adenocarcinomatous type. Extrahepatic tumors with features that resemble hepatocellular carcinoma, often referred to as hepatoid adenocarcinomas, have been described in many different organs, and are aggressive and prognostically unfavorable. Hepatoid features of bladder cancer are unusual and rarely reported. We report a unique case of a metastatic lesion to the liver consisting of a urothelial carcinoma with hepatoid features, a tumor that likely falls within the hepatoid adenocarcinoma spectrum...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178718/urothelial-carcinoma-with-squamous-differentiation-is-associated-with-high-tumor-stage-and-pelvic-lymph-node-metastasis
#16
Yunguang Liu, Marilyn M Bui, Bo Xu
BACKGROUND: Squamous differentiation occurs in up to 20% of urothelial carcinoma cases and is thought to be an unfavorable prognostic factor. METHODS: Data from urothelial carcinoma in patients treated with cystectomy from 2002 to 2014 at Roswell Park Cancer Institute were retrospectively reviewed. A 2-tier system was adopted for stage analysis. T1 and T2 disease were grouped in organ-confined and low-stage categories, whereas T3 and T4 disease were grouped in high-stage categories...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28174011/prognostic-role-of-neutrophil-to-lymphocyte-ratio-based-markers-during-pre-and-postadjuvant-chemotherapy-in-patients-with-advanced-urothelial-carcinoma-of-upper-urinary-tract
#17
Minyong Kang, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
PURPOSE: The aim of the present study was to assess the prognostic significance of neutrophil-to-lymphocyte ratio (NLR)-based markers before and after adjuvant chemotherapy (ACH) in patients with urothelial carcinoma of the upper urinary tract (UTUC) undergoing radical nephroureterectomy (RNU) and ACH. MATERIALS AND METHODS: The data from 112 patients with advanced UTUC who had undergone first-line ACH after RNU from 1994 to 2012 were reviewed. After excluding 22 patients, the clinicopathologic data for 90 patients were analyzed, in particular, the NLR and derived NLR (dNLR) preoperatively and before and after ACH...
January 12, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28169993/the-evolving-genomic-landscape-of-urothelial-carcinoma
#18
REVIEW
Alexander P Glaser, Damiano Fantini, Ali Shilatifard, Edward M Schaeffer, Joshua J Meeks
Survival of patients with urothelial carcinoma (including bladder cancer and upper tract urothelial carcinoma) is limited by our current approaches to staging, surgery, and chemotherapy. Large-scale, next-generation sequencing collaborations, such as The Cancer Genome Atlas, have already identified drivers and vulnerabilities of urothelial carcinoma. This disease has a high degree of mutational heterogeneity and a high frequency of somatic mutations compared with other solid tumours, potentially resulting in an increased neoantigen burden...
February 7, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28168374/non-contrast-magnetic-resonance-imaging-for-bladder-cancer-fused-high-b-value-diffusion-weighted-imaging-and-t2-weighted-imaging-helps-evaluate-depth-of-invasion
#19
Minsu Lee, Su-Jin Shin, Young Taik Oh, Dae Chul Jung, Nam Hoon Cho, Young Deuk Choi, Sung Yoon Park
OBJECTS: To investigate the utility of fused high b value diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI) for evaluating depth of invasion in bladder cancer. METHODS: We included 62 patients with magnetic resonance imaging (MRI) and surgically confirmed urothelial carcinoma in the urinary bladder. An experienced genitourinary radiologist analysed the depth of invasion (T stage <2 or ≥2) using T2WI, DWI, T2WI plus DWI, and fused DWI and T2WI (fusion MRI)...
February 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28166762/clasp2-is-involved-in-the-emt-and-early-progression-after-transurethral-resection-of-the-bladder-tumor
#20
Bisong Zhu, Lin Qi, Sulai Liu, Wentao Liu, Zhenyu Ou, Minfeng Chen, Longfei Liu, Xiongbing Zu, Jun Wang, Yuan Li
BACKGROUND: Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localizes to the distal ends of microtubules and regulate microtubule dynamics. We speculated that it might be involved in the epithelial-mesenchymal transition (EMT) and progression of bladder cancer (BC). METHODS: Western blotting and RT-PCR were used to detect the changes at protein and mRNA levels in BC cell lines. Cell proliferation, clonogenic formation, wound healing and chamber invasion assay were used to investigate the abilities of cellular proliferation, migration and invasion...
February 6, 2017: BMC Cancer
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