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Central line infection

Suparna Bagchi, Jennifer Watkins, Daniel A Pollock, Jonathan R Edwards, Katherine Allen-Bridson
BACKGROUND: Numerous state health departments (SHDs) have validated central line-associated bloodstream infection (CLABSI) data, and results from these studies provide important insights into the accuracy of CLABSI reporting to the National Healthcare Safety Network (NHSN) and remediable shortcomings in adherence to the CLABSI definition and criteria. METHODS: State CLABSI validation results were obtained from peer-reviewed publications, reports on SHD Web sites, and via personal communications with the SHD health care-associated infections coordinator...
June 11, 2018: American Journal of Infection Control
Karina Sichieri, Luciana Inaba Senyer Iida, Isa Rodrigues da Silveira Cabral de Menezes, Paulo Carlos Garcia, Talita Raquel Santos, Emília Peres, Gilcéria Tochika Shimoda, Flávia de Oliveira Motta Maia, Silvia Regina Secoli, Vilanice Alves de Araújo Püschel
OBJECTIVES: This implementation project aimed to identify the current practice in regards to central venous catheters (CVCs) maintenance to improve knowledge amongst nursing staff and to assess increased compliance with evidence-based best practice. INTRODUCTION: Central venous catheters are considered an important therapeutic resource for the administration of fluids, drugs, blood, collection of blood samples and hemodynamic monitoring. Despite the benefits, catheter use is associated with complications such as primary infection of the catheter-related bloodstream...
June 2018: JBI Database of Systematic Reviews and Implementation Reports
Angela O Eni, Oghenevwairhe P Efekemo, Mojisola G Soluade, Segun I Popoola, Aderemi A Atayero
Cassava mosaic disease (CMD) is one of the most economically important viral diseases of cassava, an important staple food for over 800 million people in the tropics. Although several Cassava mosaic virus species associated with CMD have been isolated and characterized over the years, several new super virulent strains of these viruses have evolved due to genetic recombination between diverse species. In this data article, field survey data collected from 184 cassava farms in 12 South Western and North Central States of Nigeria in 2015 are presented and extensively explored...
August 2018: Data in Brief
E Eviatar, Y Golan, H Gavriel
OBJECTIVE: To describe a newly observed frontal sinus anatomical variant, the fronto-septal rostrum. METHODS: Consecutive sinus computed tomography scans performed during 2013 were reviewed. The fronto-septal rostrum was defined as a mucosa-lined air space formed in the attachment of the most upper bony nasal septum and the central floor of the frontal sinuses. RESULTS: The study included 400 computed tomography scans from 189 women (47.3 per cent) and 211 men (52...
May 2018: Journal of Laryngology and Otology
Lambert M Felix, Seamus Grundy, Stephen J Milan, Ross Armstrong, Haley Harrison, Dave Lynes, Sally Spencer
BACKGROUND: Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation of the smaller airways and associated with a mortality rate greater than twice that of the general population. Antibiotics serve as front-line therapy for managing bacterial load, but their use is weighed against the development of antibiotic resistance. Dual antibiotic therapy has the potential to suppress infection from multiple strains of bacteria, leading to more successful treatment of exacerbations, reduced symptoms, and improved quality of life...
June 11, 2018: Cochrane Database of Systematic Reviews
Pramod Pharande, Kwee B Lindrea, John Smyth, Margaret Evans, Kei Lui, Srinivas Bolisetty
AIM: Late-onset sepsis (LOS) is a frequent and important cause of morbidity and mortality in newborn infants admitted to neonatal intensive care units (NICUs). The objective of this study is to evaluate the impact of various infection control quality measures introduced as a bundle on the trends of the LOS in a NICU. METHODS: This was a prospective quality improvement study involving all neonates admitted to a NICU over a 15-year period between 2002 and 2016. The main focus areas of the bundle included collaborative team effort, hand hygiene, education, central line insertion and maintenance bundles and parenteral nutrition...
June 11, 2018: Journal of Paediatrics and Child Health
Anne F Voor In 't Holt, Onno K Helder, Margreet C Vos, Laura Schafthuizen, Sandra Sülz, Agnes van den Hoogen, Erwin Ista
No abstract text is available yet for this article.
August 2018: International Journal of Nursing Studies
Ashraf Kharrat, Amish Jain
Central venous lines (CVLs) are a crucial component of life-sustaining therapy in the neonatal intensive care unit (NICU), providing necessary medication, hydration, and parental nutrition. However, CVLs are not without complications, which commonly include infections, infiltration and thrombosis (1). Effusions are among the rarer, but more dramatic and potentially lethal complications of CVLs. This article is protected by copyright. All rights reserved.
June 9, 2018: Acta Paediatrica
Joshua Wolf, Tom G Connell, Kim J Allison, Li Tang, Julie Richardson, Kristen Branum, Eloise Borello, Jeffrey E Rubnitz, Aditya H Gaur, Hana Hakim, Yin Su, Sara M Federico, Francoise Mechinaud, Randall T Hayden, Paul Monagle, Leon J Worth, Nigel Curtis, Patricia M Flynn
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) affect about 25% of children with cancer, and treatment failure is common. Adjunctive ethanol lock therapy might prevent treatment failure but high-quality evidence is scarce. We evaluated ethanol lock therapy as treatment and secondary prophylaxis for CLABSI in children with cancer or haematological disorders. METHODS: This randomised, double-blind, placebo-controlled superiority trial, with two interim futility and efficacy analyses (done when the first 46 and 92 evaluable participants completed study requirements), was done at two paediatric hospitals in the USA and Australia...
June 5, 2018: Lancet Infectious Diseases
Dominic Wichmann, Cristina E Belmar Campos, Stephan Ehrhardt, Timo Kock, Claudia Weber, Holger Rohde, Stefan Kluge
BACKGROUND: Central line-associated bloodstream infections (CLABSI) are a major source of sepsis in modern intensive care medicine. Some years ago bundle interventions have been introduced to reduce CLABSI. The use of checklists may be an additional tool to improve the effect of these bundles even in highly specialized institutions. In this study we investigate if the introduction of a checklist reduces the frequency of CLABSI. METHODS: During the study period from October 2011 to September 2012, we investigated the effect of implementing a checklist for the placement of central venous lines (CVL)...
June 8, 2018: BMC Infectious Diseases
Elizabeth A Duffy, Margaret Rabatin
No abstract text is available yet for this article.
2018: AACN Advanced Critical Care
Nguyen Viet Hung, Phan Thi Hang, Victor D Rosenthal, Le Thi Anh Thu, Le Thi Thu Nguyet, Ngo Quy Chau, Truong Anh Thu, Dinh Pham Phuong Anh, Tran Thi My Hanh, Tran Thi Thuy Hang, Dang Thi Van Trang, Nguyen Phuc Tien, Vo Thi Hong Thoa, Đao Quang Minh
OBJECTIVE: The aim of the study was to report the results of the International Nosocomial Infection Control Consortium (INICC) study conducted from May 2008 to March 2015. METHODS: A device-associated healthcare-acquired infection surveillance study in three adult intensive care units (ICUs) and 1 neonatal ICU from 4 hospitals in Vietnam using U.S. the Centers for Disease Control and Prevention's National Healthcare Safety Network (CDC/NHSN) definitions and criteria as well as INICC methods...
June 4, 2018: Journal of Patient Safety
J Chandra, L Long, N Isham, P K Mukherjee, G DiSciullo, K Appelt, M A Ghannoum
Central line associated bloodstream infections (CLABSIs) are increasingly recognized to be associated with intralumenal microbial biofilms, and effective measures for the prevention and treatment of BSI remain lacking. This report evaluates a new commercially developed antimicrobial catheter lock solution (ACL) containing trimethoprim (5 mg/ml) and ethanol (25%) and calcium Ethylenediaminetetraacetic acid (CA-EDTA) 3% for activity against bacterial and fungal biofilms using in vitro and in vivo (rabbit) catheter biofilm models...
June 4, 2018: Antimicrobial Agents and Chemotherapy
Jacob Moell, Anna Svenningsson, Margareta Af Sandeberg, Magnus Larsson, Mats Heyman, Arja Harila-Saari, Anna Nilsson
AIM: This study examined the clinical characteristics of central line associated blood stream infections occurring within 30 days after insertion versus later infections in paediatric cancer patients, and the subsequent risk for premature catheter removal. METHODS: This was a retrospective study of children aged 0-18 years who were diagnosed with cancer from 2013-2014 at the Astrid Lindgren Children Hospital, Sweden. Clinical and microbiology data for each patient was collected for 365 days after the central venous catheter was inserted...
June 4, 2018: Acta Paediatrica
Victor Emmanuel Viana Geddes, Anibal Silva de Oliveira, Amilcar Tanuri, Eurico Arruda, Marcelo Ribeiro-Alves, Renato Santana Aguiar
Oropouche Virus is the etiological agent of an arbovirus febrile disease that affects thousands of people and is widespread throughout Central and South American countries. Although isolated in 1950's, still there is scarce information regarding the virus biology and its prevalence is likely underestimated. In order to identify and elucidate interactions with host cells factors and increase the understanding about the Oropouche Virus biology, we performed microRNA (miRNA) and target genes screening in human hepatocarcinoma cell line HuH-7...
May 29, 2018: PLoS Neglected Tropical Diseases
Song Hong, Yi Liu, Huazhang Xiong, Dongfeng Cai, Qinghong Fan
Eukaryotic translation initiation factor 3H subunit (EIF3H) is a member of the EIF3 family and exhibits a central role in translation initiation in higher eukaryotes. Although EIF3H expression is upregulated in numerous tumour types, its potential role in human osteosarcoma (OS) has not yet been investigated. In the present study, it was demonstrated that EIF3H mRNA expression was upregulated in the human OS cell lines Saos-2 and U2OS. A recombinant lentivirus harbouring short hairpin RNA targeting EIF3H was constructed and successfully infected human OS Saos-2 and U2OS cells, resulting in 95% downregulated EIF3H expression compared with the respective control groups...
June 2018: Experimental and Therapeutic Medicine
Julien Thézé, Tony Li, Louis du Plessis, Jerome Bouquet, Moritz U G Kraemer, Sneha Somasekar, Guixia Yu, Mariateresa de Cesare, Angel Balmaseda, Guillermina Kuan, Eva Harris, Chieh-Hsi Wu, M Azim Ansari, Rory Bowden, Nuno R Faria, Shigeo Yagi, Sharon Messenger, Trevor Brooks, Mars Stone, Evan M Bloch, Michael Busch, José E Muñoz-Medina, Cesar R González-Bonilla, Steven Wolinsky, Susana López, Carlos F Arias, David Bonsall, Charles Y Chiu, Oliver G Pybus
The Zika virus (ZIKV) epidemic in the Americas established ZIKV as a major public health threat and uncovered its association with severe diseases, including microcephaly. However, genetic epidemiology in some at-risk regions, particularly Central America and Mexico, remains limited. We report 61 ZIKV genomes from this region, generated using metagenomic sequencing with ZIKV-specific enrichment, and combine phylogenetic, epidemiological, and environmental data to reconstruct ZIKV transmission. These analyses revealed multiple independent ZIKV introductions to Central America and Mexico...
May 15, 2018: Cell Host & Microbe
Marla Clifton, Stephen M Kralovic, Loretta A Simbartl, Lisa Minor, Rachael Hasselbeck, Tina Martin, Gary A Roselle
Nursing homes present a unique challenge for implementing infection prevention and control practices while striving to maintain a home-like environment. Medical devices such as urinary catheters and central venous catheters have become a part of nursing home care but can predispose residents to associated infections. Because evidence-based prevention bundles were implemented, catheter-associated urinary tract infections (CAUTIs) and central line-associated bloodstream infections (CLABSIs) were monitored in all U...
May 24, 2018: American Journal of Infection Control
Linda Connor
PURPOSE: To describe knowledge, values, and implementation of evidence-based practice (EBP) and use of two National Patient Safety Goals-Central Line Associated Blood Stream Infections (CLABSI) and Surgical Site Infections (SSI)-between nurses working in Magnet® versus non-Magnet® designated hospitals. BACKGROUND: There is a gap in the literature concerning nurses' understanding of EBP and how EBP guidelines are used in practice and if guidelines are being used as intended...
May 22, 2018: Journal of Pediatric Nursing
Eiman Gaid, Abdullah Assiri, Scott McNabb, Weam Banjar
Healthcare-associated infections (HAIs) including device-associated HAI (DA-HAI) are a serious patient safety issue in hospitals worldwide, affecting 5-10% of hospitalized patients and deadly for patients in intensive care units (ICUs). (Vincent, 2003; Al-Tawfiq et al., 2013; Hu et al., 2013). DA-HAIs account for up to 23% of HAIs in ICUs and about 40% of all hospital infections (i.e. central line-associated blood stream infections [CLABSI], ventilator-associated pneumonia [VAP], and catheter-associated urinary tract infections [CAUTI])...
March 2018: Journal of Epidemiology and Global Health
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