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https://www.readbyqxmd.com/read/29665877/the-impact-of-2015-nhsn-catheter-associated-urinary-tract-infection-cauti-definition-change-on-central-line-associated-bloodstream-infection-clabsi-rates-and-clabsi-prevention-efforts-at-an-academic-medical-center
#1
Sonali D Advani, Rachael A Lee, Martha Long, Mariann Schmitz, Bernard C Camins
The 2015 changes in the catheter-associated urinary tract infection definition led to an increase in central line-associated bloodstream infections (CLABSIs) and catheter-related candidemia in some health systems due to the change in CLABSI attribution. However, our rates remained unchanged in 2015 and further declined in 2016 with the implementation of new vascular-access guidelines.Infect Control Hosp Epidemiol 2018;1-3.
April 18, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29665727/changes-in-central-line-associated-bloodstream-infection-rates-among-children-with-immune-compromised-conditions-an-11-year-review
#2
Lauri A Linder, Cheryl Gerdy, Yeonjung Jo, Andrew Wilson
This article describes changes in central line-associated bloodstream infection (CLABSI) rates among common causative organisms over an 11-year period on a pediatric inpatient unit prior to and following CLABSI reduction strategies. The setting for this descriptive cohort design study was a 32-bed inpatient unit in a tertiary pediatric hospital serving children with immune compromised conditions, including cancer and recipients of hematopoietic stem cell and solid organ transplants. Between January 2006 and December 2016, 265 CLABSIs involving 189 patients were reported...
April 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29661634/assessing-patient-risk-of-central-line-associated-bacteremia-via-machine-learning
#3
Cole Beeler, Lana Dbeibo, Kristen Kelley, Levi Thatcher, Douglas Webb, Amadou Bah, Patrick Monahan, Nicole R Fowler, Spencer Nicol, Alisa Judy-Malcolm, Jose Azar
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) contribute to increased morbidity, length of hospital stay, and cost. Despite progress in understanding the risk factors, there remains a need to accurately predict the risk of CLABSIs and, in real time, prevent them from occurring. METHODS: A predictive model was developed using retrospective data from a large academic healthcare system. Models were developed with machine learning via construction of random forests using validated input variables...
April 13, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29659627/n6-methyladenosine-modification-and-the-ythdf2-reader-protein-play-cell-type-specific-roles-in-lytic-viral-gene-expression-during-kaposi-s-sarcoma-associated-herpesvirus-infection
#4
Charles Hesser, John Karijolich, Dan Dominissini, Chuan He, Britt A Glaunsinger
Methylation at the N6 position of adenosine (m6A) is a highly prevalent and reversible modification within eukaryotic mRNAs that has been linked to many stages of RNA processing and fate. Recent studies suggest that m6A deposition and proteins involved in the m6A pathway play a diverse set of roles in either restricting or modulating the lifecycles of select viruses. Here, we report that m6A levels are significantly increased in cells infected with the oncogenic human DNA virus Kaposi's sarcoma-associated herpesvirus (KSHV)...
April 16, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29650343/safety-efficacy-and-management-of-subcutaneous-treprostinil-infusions-in-the-treatment-of-severe-pediatric-pulmonary-hypertension
#5
Marilyne Levy, Maria-Jesus Del Cerro, Sophie Nadaud, Karunakar Vadlamudi, Elizabeth Colgazier, Jeff Fineman, Damien Bonnet, Ian Adatia
BACKGROUND: Continuous intravenous epoprostenol was the first treatment approved for pulmonary arterial hypertension (PAH) but administration through a central venous line carries risks of thrombosis and sepsis, particularly in children. We sought to evaluate the safety, efficacy and management of subcutaneous (SC) treprostinil in children with PAH. METHODS: Fifty-six children (median age 65, range 1-200 months) were treated with SC treprostinil. Clinical status, echocardiography, NT-proBNP, and site pain and infection were evaluated...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29649549/bloodstream-infections-in-cancer-patients-risk-factors-associated-with-mortality
#6
Beda Islas-Muñoz, Patricia Volkow-Fernández, Cynthia Ibanes-Gutiérrez, Alberto Villamar-Ramírez, Diana Vilar-Compte, Patricia Cornejo-Juárez
OBJECTIVE: The aim of this study was to evaluate the clinical characteristics and risk factors associated with mortality in cancer patients with bloodstream infections (BSI), analyzing multidrug resistant bacteria (MDRB). METHODS: We conducted a prospective observational study at a cancer referral center from August 2016 to July 2017, which included all BSI. RESULTS: 4,220 patients were tested with blood cultures; 496 were included. Mean age was 48 years...
April 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29624084/recent-developments-in-interferon-based-therapies-for-multiple-sclerosis
#7
Laura Dumitrescu, Cris S Constantinescu, Radu Tanasescu
Multiple sclerosis (MS) is a chronic and disabling immune-mediated disease of the central nervous system. Beta-interferons are the first approved and still the most widely used first-line disease-modifying treatment in MS. Areas covered: Here we focus on recent developments in pharmacology and delivery systems of beta-interferons, and discuss their place within current state of the art therapeutic approaches. We briefly review the clinical trials for classical and PEGylated formulations, emphasizing effectiveness, safety concerns, and tolerability...
April 6, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29620619/enews-tool-to-prevent-central-line-associated-bloodstream-infection
#8
Theresa Morrison
No abstract text is available yet for this article.
April 2018: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29619366/targeting-endoplasmic-reticulum-and-or-mitochondrial-ca-2-fluxes-as-therapeutic-strategy-for-hcv-infection
#9
Rosella Scrima, Claudia Piccoli, Darius Moradpour, Nazzareno Capitanio
Chronic hepatitis C is characterized by metabolic disorders and by a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that can in the long term lead to liver cirrhosis and hepatocellular carcinoma. Several lines of evidence suggest that mitochondrial dysfunctions play a central role in these processes. However, how these dysfunctions are induced by the virus and whether they play a role in disease progression and neoplastic transformation remains to be determined...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29619341/right-carotid-cutaneous-fistula-and-right-carotid-pseudoaneurysm-formation-secondary-to-a-chronically-infected-polyethylene-terephthalate-patch
#10
W T Hillman Terzian, Samuel Schadt, Sharvil U Sheth
Carotid endarterectomy (CEA) remains the treatment for significant carotid stenosis and stroke prevention. Approximately 100,000 CEAs are performed in the United States every year. Randomized trials have demonstrated an advantage of patch carotid angioplasty over primary closure. Complications from patches include thrombosis, transient ischemic attack, stroke, restenosis, pseudoaneurysm (PA), and infection. PA after CEA is rare, with a reported average of 0.37% of cases. We describe an unusual case of PA after polyethylene terephthalate (PTFE) patching for CEA...
January 2018: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29619323/bacteremia-caused-by-cellulosimicrobium-in-a-bone-marrow-transplant-patient-a-case-report-and-literature-review
#11
Jose Armando Gonzales Zamora, Nicholas Camps
Background: Cellulosimicrobium sp. is a ubiquitous gram-positive bacillus that was formerly known as Oerskovia. This bacterium is found in soil and decaying plant material and is rarely associated with infections in humans. Case report: We report the case of a 44 year-old woman with history of bone marrow transplant that developed Cellulosimicrobium sp. bacteremia secondary to a central line infection. She was admitted with presumed sepsis. Blood cultures from central line and periphery revealed the growth of gram-positive rods that were further identified as Cellulosimicrobium sp ...
2018: IDCases
https://www.readbyqxmd.com/read/29619322/-burkholderia-multivorans-a-rare-yet-emerging-cause-of-bacterial-meningitis
#12
Diego P Peralta, Aymara Y Chang, Angie Ariza-Hutchinson, Catherine A Ho
Burkholderia multivorans is a member of the Burkholderia cepacia complex. Although it is usually associated with infections in patients with cystic fibrosis, chronic granulomatous disease, and immunosuppression, central nervous infections are not commonly reported. Moreover, management of these infections is difficult due to multiple mechanisms of bacterial resistance to antimicrobial agents. We report a 55-year-old-man who developed Burkholderia multivorans meningitis after two episodes of central line-associated bloodstream infections...
2018: IDCases
https://www.readbyqxmd.com/read/29618972/an-inflammation-centric-view-of-neurological-disease-beyond-the-neuron
#13
REVIEW
Stephen D Skaper, Laura Facci, Morena Zusso, Pietro Giusti
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious. While inflammation per se may not cause disease, it contributes importantly to disease pathogenesis across both the peripheral (neuropathic pain, fibromyalgia) and central [e...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29615158/reduction-in-central-line-associated-bloodstream-infections-in-a-nicu-practical-lessons-for-its-achievement-and-sustainability
#14
Judith A Hawes, Kyong-Soon Lee
Central venous catheters are commonly used for the provision of parenteral nutrition and medications for critically ill neonates in the NICU. However, central line-associated bloodstream infections (CLABSIs) are a major complication associated with their use and remain an important cause of nosocomial sepsis in NICUs. Central line-associated bloodstream infection has shifted from being an expected routine complication of central line use to an adverse event now evaluated as a critical event with the goal of identifying root causes so future CLABSI events are prevented...
March 1, 2018: Neonatal Network: NN
https://www.readbyqxmd.com/read/29611399/effect-of-central-line-bundle-compliance-on-central-line-associated-bloodstream-infections
#15
Kyoung Hwa Lee, Nan Hyoung Cho, Su Jin Jeong, Mi Na Kim, Sang Hoon Han, Young Goo Song
PURPOSE: The present study aimed to evaluate the effect of central line (CL) bundle compliance on central line-associated bloodstream infections (CLABSIs) in different departments of the same hospital, including the intensive care unit (ICU) and other departments. MATERIALS AND METHODS: The four components of the CL bundle were hand hygiene, use of maximal sterile barrier precautions, chlorhexidine use, and selection of an appropriate site for venous access. Compliance of the CL bundle and CLABSIs were measured for every department [emergency room (ER), ICU, general ward (GW), and operating room (OR)]...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29610163/recanalization-of-occluded-central-veins-in-a-parenteral-nutrition-dependent-child-with-no-access
#16
Patrick M Sullivan, Russell Merritt, Juan Carlos Pelayo, Frank F Ing
Central venous thromboses are common and pose challenges in the care of chronically ill pediatric patients. Among patients with intestinal failure (most commonly because of short bowel syndrome) who depend on parenteral nutrition, progressive loss of central venous access sites is a potentially fatal complication. We present the case of a 5-year-old girl with parenteral nutrition-dependent short bowel syndrome and no remaining standard central venous access sites despite medical anticoagulation, in whom angioplasty and stent implantations were used to reconstruct chronically occluded central veins...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29604981/global-developments-in-hiv-neurology
#17
Edwina J Wright, Kiran T Thakur, David Bearden, Gretchen L Birbeck
Neurologic conditions associated with HIV remain major contributors to morbidity and mortality, and are increasingly recognized in the aging population on long-standing combination antiretroviral therapy (cART). Importantly, growing evidence suggests that the central nervous system (CNS) serves as a reservoir for viral replication with major implications for human immunodeficiency virus (HIV) eradication strategies. Though there has been major progress in the last decade in our understanding of the pathogenesis, burden, and impact of HIV-associated neurologic conditions, significant scientific gaps remain...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29596237/newscap-central-line-associated-bloodstream-infections-clabsis-in-u-s-hospitals-decreased-50-between-2008-and-2016
#18
(no author information available yet)
No abstract text is available yet for this article.
April 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29592961/lysosome-mediated-plasma-membrane-repair-is-dependent-on-the-small-gtpase-arl8b-and-determines-cell-death-type-in-mycobacterium-tuberculosis-infection
#19
Xavier Michelet, Amit Tuli, Huixian Gan, Carolina Geadas, Mahak Sharma, Heinz G Remold, Michael B Brenner
Mycobacterium tuberculosis is an extremely successful pathogen, and its success is widely attributed to its ability to manipulate the intracellular environment of macrophages. A central phenomenon of tuberculosis pathology enabling immune evasion is the capacity of virulent M. tuberculosis (H37Rv) to induce macrophage necrosis, which facilitates the escape of the mycobacteria from the macrophage and spread of infection. In contrast, avirulent M. tuberculosis (H37Ra) induces macrophage apoptosis, which permits Ag presentation and activation of adaptive immunity...
March 28, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29588187/effect-of-chlorhexidine-baths-on-central-line-associated-bloodstream-infections-in-a-neonatal-intensive-care-unit-in-a-developing-country
#20
D Cleves, J Pino, J A Patiño, F Rosso, J D Vélez, P Pérez
Healthcare-associated infections, especially central line-associated bloodstream infections (CLABSIs) are worrisome in neonates. We describe the impact of chlorhexidine baths on CLABSI rates in a Neonatal Intensive Care Unit in a developing country, through a quasi-experimental study undertaken during a 62-month period, from January 2012 to February 2017, divided in two periods, before and after the implementation of a protocol for chlorhexidine baths in July 2014. The rate of CLABSIs per 1,000 central line-days decreased from 8...
March 24, 2018: Journal of Hospital Infection
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