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https://www.readbyqxmd.com/read/29050112/-clinical-pathologic-characteristics-and-treatment-outcomes-of-19-relapsed-pediatric-b-cell-lymphoma
#1
S Huang, L Jin, J Yang, Y L Duan, M Zhang, C J Zhou, X L Ma, Y H Zhang
Objective: To review the clinical-pathology characteristics of 19 relapsed pediatric mature B cell lymphoma and to find the risk factors for recurrence and the feasible treatment after relapse. Method: Data of 212 pediatric B cell lymphomas cases in Beijing Children's Hospital from January 2006 to June 2015 were collected retrospectively. All the patients were treated according to the B cell lymphoma regimen of Beijing Children's Hospital. During the study period, 19 of 212 cases were relapsed; the clinio-pathological characteristics of relapsed patients before treatment and after relapse were analyzed retrospectively, the treatment outcomes after relapse were summarized and the patients were followed-up...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29048409/maternal-milk-feedings-reduce-sepsis-necrotizing-enterocolitis-and-improve-outcomes-of-premature-infants
#2
J Cortez, K Makker, D F Kraemer, J Neu, R Sharma, M L Hudak
OBJECTIVE: Human milk (donor milk (DM) and/or maternal milk (MM)) feedings protect against late onset sepsis (LOS), necrotizing enterocolitis (NEC) and death. However, DM lacks many anti-infective components of MM. Therefore, we studied exclusive MM feedings to evaluate the full effect of human milk on infectious and other outcomes in premature infants. STUDY DESIGN: All infants born before 33 weeks postmenstrual age (PMA) who received exclusive (>95%) MM or exclusive preterm formula (PF) were included in this prospective investigation...
October 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29046215/prospective-surveillance-of-device-associated-health-care-associated-infection-in-an-intensive-care-unit-of-a-tertiary-care-hospital-in-new-delhi-india
#3
Shilpee Kumar, Poornima Sen, Rajni Gaind, Pardeep Kumar Verma, Poonam Gupta, Prem Rose Suri, Sunita Nagpal, Anil Kumar Rai
BACKGROUND: Surveillance of health care-associated infections (HAIs) plays a key role in the hospital infection control program and reduction of HAIs. In India, most of the surveillance of HAIs is reported from private sector hospitals that do not depict the situation of government sector hospitals. Other studies do not confirm with the Centers for Disease Control and Prevention's (CDC) National Healthcare Safety Network (NHSN) surveillance criterion, or deal with ventilator-associated pneumonia (VAP) instead of ventilator-associated event (VAE)...
October 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29039051/hidden-morbidity-of-ethanol-lock-therapy
#4
Teerin T Meckmongkol, Caitlyn Costanzo, Sean Ciullo, Rajeev Prasad, L Grier Arthur
AIMS: Long-term central venous catheters are essential in sustaining growth and development in patients with intestinal failure (IF). Several strategies have been developed to prevent and treat catheter-related blood stream infections (CRBSIs), including ethanol lock therapy. We sought to evaluate the efficacy of ethanol lock therapy in our IF population. METHOD: This is a retrospective review of IF patients treated with ethanol lock therapy at a single institution from 2006 to 2013...
October 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29031864/bloodstream-infections-following-different-types-of-surgery-in-a-finnish-tertiary-care-hospital-2009-2014
#5
Kirsi Skogberg, Keiju S K Kontula, Asko Järvinen, Outi Lyytikäinen
We evaluated the risk and outcome of bloodstream infections (BSIs) following surgery. BSIs were identified in Helsinki University Hospital during 2009-2014 as part of the national surveillance. Of 711 BSIs identified, 51% were secondary and 49% primary. The rate was highest after cardiovascular surgery (8.7/1000 procedures) and lowest after gynaecologic (1.0/1000). Surgical site infection was the most common source of secondary BSIs (34%) and 45% of primary BSIs were central line-associated. The 28-day case fatality ranged from 0% in gynaecology/obstetrics to 21% in cardiovascular surgery...
October 12, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29031430/leadership-line-care-rounds-application-of-the-engage-educate-execute-and-evaluate-improvement-model-for-the-prevention-of-central-line-associated-bloodstream-infections-in-children-with-cancer
#6
Angie Owings, JoBeth Graves, Sherry Johnson, Craig Gilliam, Mike Gipson, Hana Hakim
To prevent central line-associated bloodstream infections (CLABSIs), leadership line care rounds (LLCRs) used the engage, educate, execute, and evaluate improvement model to audit compliance, identify barriers and opportunities, empower patients and families, and engage leadership. Findings of excellence and improvement opportunities were communicated to unit staff and managers. LLCRs contributed to compliance with CLABSI prevention interventions.
October 11, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29030929/infection-prevention-in-pediatric-anesthesia-practice
#7
REVIEW
Lizabeth D Martin, Michael Kallile, Siri Kanmanthreddy, Danielle M Zerr
Healthcare-associated infections are an important source of morbidity and mortality in pediatric patients. Anesthesiologists have a unique role in infection prevention. Hand hygiene and anesthesia workspace decontamination decrease infection rates in surgical patients. Standard protocols exist for insertion and handling of central lines, arterial lines, and regional procedures, which should be strictly adhered to in order to prevent infectious complications. Temperature control and timely administration of antibiotics contribute to the prevention of surgical site infections...
November 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29026536/implementation-of-central-line-associated-bloodstream-infection-prevention-bundles-in-a-surgical-intensive-care-unit-using-peer-tutoring
#8
Sang-Won Park, Suhui Ko, Hye-Sun An, Ji Hwan Bang, Woo-Young Chung
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) can be prevented through well-coordinated, multifaceted programs. However, implementation of CLABSI prevention programs requires individualized strategies for different institutional situations, and the best strategy in resource-limited settings is uncertain. Peer tutoring may be an efficient and effective method that is applicable in such settings. METHODS: A prospective intervention was performed to reduce CLABSIs in a surgical intensive care unit (SICU) at a tertiary hospital...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29020436/short-course-versus-long-course-intravenous-therapy-with-the-same-antibiotic-for-severe-community-acquired-pneumonia-in-children-aged-two-months-to-59-months
#9
REVIEW
Zohra S Lassi, Aamer Imdad, Zulfiqar A Bhutta
BACKGROUND: Pneumonia is a leading cause of childhood mortality from infectious disease, responsible for an estimated 1.3 million deaths annually in children under five years of age, many of which are in low-income countries. The World Health Organization recommends intravenous antibiotics for five days as first-line treatment for children with severe pneumonia. Although controversy exists regarding the specific clinical features used to diagnose pneumonia, the criteria for diagnosis of severe pneumonia are better defined and are widely used to triage children for referral and second-line therapy...
October 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29020307/follow-up-blood-cultures-in-gram-negative-bacteremia-are-they-needed
#10
Christina N Canzoneri, Bobak J Akhavan, Zehra Tosur, Pedro E Alcedo Andrade, Gabriel M Aisenberg
Background: Bloodstream infections remain a major cause of morbidity and mortality. Gram-negative bacilli (GNB) bacteremia is typically transient and usually resolves rapidly after the initiation of appropriate antibiotic therapy and source control. The optimal duration of treatment and utility of follow-up blood cultures (FUBC) have not been studied in detail. Currently, the management of Gram-negative bacteremia is determined by clinical judgment. To investigate the value of repeat blood cultures, we analyzed 500 episodes of bacteremia to determine frequency of FUBC and identify risk factors for persistent bacteremia...
July 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28991817/the-moderating-role-of-hospital-size-on-the-relationship-between-patient-experience-and-patient-safety
#11
Geoffrey A Silvera
OBJECTIVES: Previous examinations of the relationship between patient experience and patient safety initiatives find that higher patient experience evaluations correspond to reduced incidence of adverse events. Little is known, however, about the impact of hospital organizational characteristics on this relationship. The purpose of this study is to examine the degree to which hospital size moderates the relationship between patient experience and patient safety. METHODS: A lagged cross-sectional ordinary least squares regression tests a hypothesis of a diminishing effect of hospital size on the relationship between patient evaluations of their interpersonal care experience and hospital's central-line associated bloodstream infection (CLABSI) is tested on a sample of 1740 US hospitals using data compiled from Hospital Compare and the American Hospital Association...
October 2017: Quality Management in Health Care
https://www.readbyqxmd.com/read/28989500/prospective-multicentre-study-in-intensive-care-units-in-five-cities-from-the-kingdom-of-saudi-arabia-impact-of-the-international-nosocomial-infection-control-consortium-inicc-multidimensional-approach-on-rates-of-central-line-associated-bloodstream-infection
#12
Hail M Al-Abdely, Areej Dhafer Alshehri, Victor Daniel Rosenthal, Yassir Khidir Mohammed, Weam Banjar, Pablo Wenceslao Orellano, Abdullah Mufareh Assiri, Nahla Moustafa Abedel Kader, Hessa Abdullah Al Enizy, Diaa Abdullah Mohammed, Duaa Khalil Al-Awadi, Analen Fabros Cabato, Maria Wasbourne, Randa Saliya, Rosita Gasmin Aromin, Evangelina Balon Ubalde, Hanan Hanafy Diab, Modhi Abdullah Alkamaly, Nawal Mohammed Alanazi, Ibtesam Yahia Hassan Assiry, Apsia Musa Molano, Celia Flores Baldonado, Mohamed Al-Azhary, Sharifa Al Atawi, Apsia Musa Molano, Fatima Mohammad Al Adwani, Arlu Marie Casuyon Pahilanga, Raslan Nakhla, Fatma Mohammad Al Adwani, Deepa Sasithran Nair, Grace Sindayen, Annalyn Amor Malificio, Najla Jameel Helali, Haya Barjas Al Dossari, Ashraf Kelany, Abdulmajid Ghowaizi Algethami, Leigh Yanne, Avigail Tan, Sheema Babu, Shatha Mohammad Abduljabbar, Syed Zahid Bukhari, Roaa Hasan Basri, Jeyashri Jaji Mushtaq, Hala Rushdi, Abdullah Abdulaziz Turkistani, Jerlie Mae Gonzales Celiz, Mohammed Abdullah Al Raey, Ibrahim Am Al-Zaydani Asiri, Saeed Ali Aldarani, Elizabeth Laungayan Cortez, Nadia Lynette Demaisip, Misbah Rehman Aziz, Ali Omer Abdul Aziz, Batool Al Manea, Eslam Samy, Mervat Al-Dalaton, Mohammed Jkedeb Alaliany
OBJECTIVE: To analyse the impact of the International Nosocomial Infection Control Consortium (INICC) Multidimensional Approach (IMA) and INICC Surveillance Online System (ISOS) on central line-associated bloodstream infection (CLABSI) rates in five intensive care units (ICUs) from October 2013 to September 2015. DESIGN: Prospective, before-after surveillance study of 3769 patients hospitalised in four adult ICUs and one paediatric ICU in five hospitals in five cities...
January 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/28985843/total-parenteral-nutrition-in-patients-following-pancreaticoduodenectomy-lessons-from-1184-patients
#13
Cullen E Worsh, Talar Tatarian, Awinder Singh, Michael J Pucci, Jordan M Winter, Charles J Yeo, Harish Lavu
BACKGROUND: Total parenteral nutrition (TPN) has historically been used conservatively in the management of patients after pancreaticoduodenectomy (PD). Herein, we evaluate the indications for and outcomes associated with TPN use in a high-volume pancreatic surgery center. MATERIALS AND METHODS: We retrospectively queried our institution's pancreatic surgery database for patients who received TPN after PD from 2006 through 2015. RESULTS: Of 1184 patients who underwent PD, 232 (19...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28968560/human-b-cells-fail-to-secrete-type-i-interferons-upon-cytoplasmic-dna-exposure
#14
Anna M Gram, Chenglong Sun, Sanne L Landman, Timo Oosenbrug, Hester J Koppejan, Mark J Kwakkenbos, Rob C Hoeben, Søren R Paludan, Maaike E Ressing
Most cells are believed to be capable of producing type I interferons (IFN I) as part of an innate immune response against, for instance, viral infections. In macrophages, IFN I is potently induced upon cytoplasmic exposure to foreign nucleic acids. Infection of these cells with herpesviruses leads to triggering of the DNA sensors interferon-inducible protein 16 (IFI16) and cyclic GMP-AMP (cGAMP) synthase (cGAS). Thereby, the stimulator of interferon genes (STING) and the downstream molecules TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are sequentially activated culminating in IFN I secretion...
September 29, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28967509/skin-antisepsis-with-0-05-sodium-hypochlorite-before-central-venous-catheter-insertion-in-neonates-a-2-year-single-center-experience
#15
Matilde Ciccia, Roksana Chakrokh, Dario Molinazzi, Angela Zanni, Patrizia Farruggia, Fabrizio Sandri
AIM: The study reports a 2-year single-center experience of the practice of skin antisepsis using a 0.05% sodium hypochlorite solution before central venous catheter placement in neonates. METHODS: Eligible subjects included any hospitalized neonate who needed a central line for at least 48 hours. Infants were excluded if they had a generalized or localized skin disorder. An ad hoc Excel (Microsoft Corp, Redmond, WA) file was used to record the data from each patient...
September 26, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28966490/care-bundle-approach-to-reduce-device-associated-infections-in-a-tertiary-care-teaching-hospital-south-india
#16
Suman Susan Prakash, Deepashree Rajshekar, Anusha Cherian, Apurba Sankar Sastry
CONTEXT: The care bundle approach is a set of evidence-based practices that when performed collectively and reliably have been shown to improve the patient outcome. AIMS: To evaluate the impact of the bundle care approach on reducing device-associated infections (DAIs). SETTINGS AND DESIGN: The study was conducted at a tertiary care hospital, South India. The study period was from January 2016 to September 2016 which was divided into three phases, each comprising 3 months...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28966069/biotimer-assay-a-reliable-and-rapid-method-for-the-evaluation-of-central-venous-catheter-microbial-colonization
#17
Luigi Rosa, Antimo Cutone, Monica Coletti, Maria Stefania Lepanto, Mellani Scotti, Piera Valenti, Giammarco Raponi, Maria Cristina Ghezzi, Francesca Berlutti
Adherent bacteria and biofilm frequently colonize central venous catheters (CVCs). CVC colonization is correlated to infections and particularly to bloodstream ones. The classical microbiological methods to determine of CVC colonization are not fully reliable and are time-consuming. BioTimer Assay (BTA) is a biological method already used to count bacteria adherent to abiotic surfaces and biofilm without sample manipulation. BTA employs specific reagents whose color changed according to bacterial metabolism...
September 29, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28958153/does-surveillance-bias-influence-the-validity-of-measures-of-inpatient-complications-a-systematic-review
#18
Liang Chen, Jeffrey A Chan, Elaine Alligood, Amy K Rosen, Ann M Borzecki
Surveillance bias may threaten the accuracy of inpatient complication measures. A systematic literature review was conducted to examine whether surveillance bias influences the validity of selected Patient Safety Indicator- and health care associated infection-related measures. Ten venous thromboembolism (VTE) articles were identified: 7 trauma related, 3 postoperative, and 1 central line-associated bloodstream infection (CLABSI) article. Nine VTE articles found positive associations between deep vein thrombosis imaging and VTE diagnoses...
September 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28951581/acute-graft-versus-host-disease-of-the-gut-considerations-for-the-gastroenterologist
#19
REVIEW
Steven Naymagon, Leonard Naymagon, Serre-Yu Wong, Huaibin Mabel Ko, Anne Renteria, John Levine, Jean-Frederic Colombel, James Ferrara
Haematopoietic stem cell transplantation (HSCT) is central to the management of many haematological disorders. A frequent complication of HSCT is acute graft-versus-host disease (GVHD), a condition in which immune cells from the donor attack healthy recipient tissues. The gastrointestinal system is among the most common sites affected by acute GVHD, and severe manifestations of acute GVHD of the gut portends a poor prognosis in patients after HSCT. Acute GVHD of the gastrointestinal tract presents both diagnostic and therapeutic challenges...
September 27, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28951444/quantitative-analysis-of-proteome-modulations-in-alveolar-epithelial-type-ii-cells-in-response-to-pulmonary-aspergillus-fumigatus-infection
#20
Pegah Seddigh, Thilo Bracht, Valerie Molinier-Frenkel, Flavia Castellano, Olaf Kniemeyer, Marc Schuster, Juliane Weski, Anja Hasenberg, Andreas Kraus, Gernot Poschet, Thomas Hager, Dirk Theegarte, Christiane Opitz, Axel A Brakhage, Barbara Sitek, Mike Hasenberg, Matthias Gunzer
The ubiquitous mold Aspergillus fumigatus threatens immunosuppressed patients as inducer of lethal invasive aspergillosis. A. fumigatus conidia are airborne and reach the alveoli, where they encounter alveolar epithelial cells (AEC). Previous studies reported the importance of the surfactant-producing AEC II during A. fumigatus infection via in vitro experiments using cell lines. We established a negative isolation protocol yielding untouched primary murine AEC II with a purity >90 %, allowing ex vivo analyses of the cells, which encountered the mold in vivo...
September 26, 2017: Molecular & Cellular Proteomics: MCP
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