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https://www.readbyqxmd.com/read/29765019/relationship-between-circulating-vascular-endothelial-growth-factor-and-its-soluble-receptor-in-patients-with-hemorrhagic-fever-with-renal-syndrome
#1
Emil Pal, Misa Korva, Katarina Resman Rus, Nataša Kejžar, Petra Bogovič, Franc Strle, Tatjana Avšič-Županc
Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2) in HFRS patients infected with Dobrava (DOBV) or Puumala virus (PUUV). VEGF and sVEGFR-2 levels were measured in daily plasma and urine samples of 73 patients with HFRS (58 with PUUV, 15 with DOBV) and evaluated in relation to clinical and laboratory variables...
May 16, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29577655/first-insights-into-puumala-orthohantavirus-circulation-in-a-rodent-population-in-alsace-france
#2
E Monchatre-Leroy, S Murri, G Castel, D Calavas, F Boué, V Hénaux, P Marianneau
In-depth knowledge on the mechanisms that maintain infection by a zoonotic pathogen in an animal reservoir is the key to predicting and preventing transmission to humans. The Puumala orthohantavirus (PUUV), the most prevalent orthohantavirus in Western Europe, causes a mild form of haemorrhagic fever with renal syndrome (HFRS) in humans. In France, this endemic illness affects the north-eastern part of the country. We conducted a 4-year capture-mark-recapture study in a bank vole population, combined with molecular analyses, to explore the epidemiological situation of PUUV in Alsace, a French region where human cases have occurred, but for which no studies have been conducted on this reservoir host...
March 25, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29404206/spatial-and-temporal-patterns-of-human-puumala-virus-puuv-infections-in-germany
#3
Sarah Cunze, Judith Kochmann, Thomas Kuhn, Raphael Frank, Dorian D Dörge, Sven Klimpel
Background: Worldwide, the number of recorded human hantavirus infections as well as the number of affected countries is on the rise. In Europe, most human hantavirus infections are caused by the Puumala virus (PUUV), with bank voles ( Myodes glareolus ) as reservoir hosts. Generally, infection outbreaks have been related to environmental conditions, particularly climatic conditions, food supply for the reservoir species and land use. However, although attempts have been made, the insufficient availability of environmental data is often hampering accurate temporal and spatially explicit models of human hantavirus infections...
2018: PeerJ
https://www.readbyqxmd.com/read/29310747/population-based-seroprevalence-of-puumala-hantavirus-in-finland-smoking-as-a-risk-factor
#4
F Latronico, S Mäki, H Rissanen, J Ollgren, O Lyytikäinen, O Vapalahti, J Sane
Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome in humans, that is an endemic disease in Finland. We estimated the seroprevalence of PUUV in Finland and explored risk factors and disease associations by using unique survey data with health register linkage. A total of 2000 sera from a nationwide health survey from 2011, representative of the adult population, were screened for PUUV IgG by immunofluorescence assay. We performed statistical analysis adjusting for stratified cluster design and taking into account sampling weights...
February 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29281106/delayed-interferon-type-1-induced-antiviral-state-is-a-potential-factor-for-hemorrhagic-fever-with-renal-syndrome-severity
#5
Katarina Resman Rus, Miša Korva, Petra Bogovic, Emil Pal, Franc Strle, Tatjana Avšic-Županc
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia. Interferon (IFN) responses play an important role in HFRS pathogenesis and early IFN-β response is delayed by pathogenic hantaviruses. The severity of HFRS caused by Dobrava virus (DOBV) and Puumala virus (PUUV) varies. Our aim was to determine whether differences in early activation of IFN type 1-induced antiviral state influence HFRS severity. Peripheral blood mononuclear cells (PBMCs) from healthy donors and HFRS patients were stimulated with DOBV or PUUV and expression of selected genes was measured...
March 5, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28986730/acute-hantavirus-infection-presenting-as-haemolytic-uraemic-syndrome-hus-the-importance-of-early-clinical-diagnosis
#6
J Clement, A P K Lee, G A Verpooten, L Laenen, V Vergote, H De Samblanx, Z N Berneman, M Van Ranst, P Maes
The European prototype of hantavirus, Puumala virus (PUUV), isolated from a common wild rodent, the bank vole (Myodes glareolus), causes nephropathia epidemica (NE). NE can perfectly mimic haemolytic-uraemic syndrome (HUS), progressing from an aspecific flu-like syndrome to acute kidney injury with thrombocytopaenia, and presenting with some signs of haemolytic anaemia and/or coagulopathy. Moreover, both NE and HUS can occur in local outbreaks. We report an isolated case of NE, initially referred for plasmapheresis for suspected HUS, although signs of overt haemolysis were lacking...
January 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28968301/diminished-coagulation-capacity-assessed-by-calibrated-automated-thrombography-during-acute-puumala-hantavirus-infection
#7
Sirpa M Koskela, Lotta Joutsi-Korhonen, Satu M Mäkelä, Heini Huhtala, Antti I Vaheri, Ilkka Pörsti, Jukka T Mustonen, Outi K Laine
: Coagulation abnormalities are associated with Puumala-virus-induced hemorrhagic fever with renal syndrome (PUUV-HFRS). We evaluated the coagulation capacity of plasma during acute PUUV-HFRS by measuring thrombin generation using calibrated automated thrombography (CAT). The study cohort comprised 27 prospectively collected, consecutive, hospital-treated patients with acute PUUV infection. Blood samples were drawn in the acute phase and at the control visit approximately 5 weeks later. To evaluate thrombin generation, the lag time of initiation, endogenous thrombin potential (ETP), and peak and time to peak thrombin concentration were assessed by CAT in platelet poor plasma without corn trypsin inhibitor...
January 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28953448/serological-survey-of-hantavirus-and-flavivirus-among-wild-rodents-in-central-italy
#8
Gian Mario Cosseddu, Giulia Sozio, Fabrizia Valleriani, Annapia Di Gennaro, Ilaria Pascucci, Stefano Gavaudan, Philippe Marianneau, Federica Monaco
Hantaviruses are a group of zoonotic viruses carried by rodents. Puumala virus (PUUV) and Dobrava virus (DOBV) are the causative agents of human hantavirus infections in Europe. Knowledge about hantavirus circulation in Italy is very scarce. West Nile virus (WNV) and Usutu virus (USUV) are emerging neuropathogenic flaviviruses, both endemic in most part of the Italian territories. To monitor the circulation of PUUV, DOBV, WNV, and USUV in natural environment in central Italy, we carried out serological surveillance in wild rodents...
November 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28943870/gastrointestinal-tract-as-entry-route-for-hantavirus-infection
#9
Peter T Witkowski, Casey C Perley, Rebecca L Brocato, Jay W Hooper, Christian Jürgensen, Jörg-Dieter Schulzke, Detlev H Krüger, Roland Bücker
Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and are thought to be transmitted to humans by exposure to aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe. A large proportion of PUUV-infected patients suffer from gastrointestinal symptoms of unclear origin. In this study we demonstrate that PUUV infection can occur via the alimentary tract. Methods: We investigated susceptibility of the human small intestinal epithelium for PUUV infection and analyzed the resistance of virions to gastric juice...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28931451/bank-vole-immunoheterogeneity-may-limit-nephropatia-epidemica-emergence-in-a-french-non-endemic-region
#10
A Dubois, G Castel, S Murri, C Pulido, J-B Pons, L Benoit, A Loiseau, L Lakhdar, M Galan, P Marianneau, N Charbonnel
Ecoevolutionary processes affecting hosts, vectors and pathogens are important drivers of zoonotic disease emergence. In this study, we focused on nephropathia epidemica (NE), which is caused by Puumala hantavirus (PUUV) whose natural reservoir is the bank vole, Myodes glareolus. We questioned the possibility of NE emergence in a French region that is considered to be NE-free but that is adjacent to a NE-endemic region. We first confirmed the epidemiology of these two regions and we demonstrated the absence of spatial barriers that could have limited dispersal, and consequently, the spread of PUUV into the NE-free region...
March 2018: Parasitology
https://www.readbyqxmd.com/read/28835498/structural-transitions-of-the-conserved-and-metastable-hantaviral-glycoprotein-envelope
#11
Ilona Rissanen, Robert Stass, Antra Zeltina, Sai Li, Jussi Hepojoki, Karl Harlos, Robert J C Gilbert, Juha T Huiskonen, Thomas A Bowden
Hantaviruses are zoonotic pathogens that cause severe hemorrhagic fever and pulmonary syndrome. The outer membrane of the hantavirus envelope displays a lattice of two glycoproteins, Gn and Gc, which orchestrate host cell recognition and entry. Here, we describe the crystal structure of the Gn glycoprotein ectodomain from the Asiatic Hantaan virus (HTNV), the most prevalent pathogenic hantavirus. Structural overlay analysis reveals that the HTNV Gn fold is highly similar to the Gn of Puumala virus (PUUV), a genetically and geographically distinct and less pathogenic hantavirus found predominantly in northeastern Europe, confirming that the hantaviral Gn fold is architecturally conserved across hantavirus clades...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28815001/serogrouping-and-seroepidemiology-of-north-european-hantaviruses-using-a-novel-broadly-targeted-synthetic-nucleoprotein-antigen-array
#12
Bengt Rönnberg, Olli Vapalahti, Marco Goeijenbier, Chantal Reusken, Åke Gustafsson, Jonas Blomberg, Åke Lundkvist
Introduction: Hantaviruses are globally distributed zoonotic pathogens. Great diversity and high antigenic cross-reactivity makes diagnosis by traditional methods cumbersome. Materials and methods: 'Megapeptides', 119-120-mers from the amino terminus of the nucleoprotein of 16 hantaviruses, representing the four major branches of the hantavirus phylogenetic tree, were utilized in a novel IgG-based hantavirus suspension multiplex immunoassay (HSMIA) for detection of past hantavirus infections in 155 North European human samples...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/28770071/dampening-of-population-cycles-in-voles-affects-small-mammal-community-structure-decreases-diversity-and-increases-prevalence-of-a-zoonotic-disease
#13
Frauke Ecke, David G Angeler, Magnus Magnusson, Hussein Khalil, Birger Hörnfeldt
Long-term decline and depression of density in cyclic small rodents is a recent widespread phenomenon. These observed changes at the population level might have cascading effects at the ecosystem level. Here, we assessed relationships between changing boreal landscapes and biodiversity changes of small mammal communities. We also inferred potential effects of observed community changes for increased transmission risk of Puumala virus (PUUV) spread, causing the zoonotic disease nephropatica epidemica in humans...
July 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28762841/haematuria-is-a-marker-for-the-severity-of-acute-kidney-injury-but-does-not-associate-with-thrombocytopenia-in-acute-puumala-hantavirus-infection
#14
Tuula K Outinen, Paula Mantula, Outi K Laine, Ilkka Pörsti, Antti Vaheri, Satu M Mäkelä, Jukka Mustonen
BACKGROUND: Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome characterized by thrombocytopenia, capillary leakage and acute kidney injury (AKI) with proteinuria and haematuria. Although the typical histologic lesion is acute tubulointerstitial nephritis, the amount of glomerular proteinuria predicts the severity of upcoming AKI. Here, we studied the associations of haematuria and proteinuria with the severity of emerging AKI, thrombocytopenia and markers of coagulation and fibrinolysis in PUUV infection...
August 1, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28747170/spatial-prediction-and-validation-of-zoonotic-hazard-through-micro-habitat-properties-where-does-puumala-hantavirus-hole-up
#15
Hussein Khalil, Gert Olsson, Magnus Magnusson, Magnus Evander, Birger Hörnfeldt, Frauke Ecke
BACKGROUND: To predict the risk of infectious diseases originating in wildlife, it is important to identify habitats that allow the co-occurrence of pathogens and their hosts. Puumala hantavirus (PUUV) is a directly-transmitted RNA virus that causes hemorrhagic fever in humans, and is carried and transmitted by the bank vole (Myodes glareolus). In northern Sweden, bank voles undergo 3-4 year population cycles, during which their spatial distribution varies greatly. METHODS: We used boosted regression trees; a technique inspired by machine learning, on a 10 - year time-series (fall 2003-2013) to develop a spatial predictive model assessing seasonal PUUV hazard using micro-habitat variables in a landscape heavily modified by forestry...
July 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28734140/deregulation-of-levels-of-angiopoietin-1-and-angiopoietin-2-is-associated-with-severe-courses-of-hantavirus-infection
#16
Christian Nusshag, Anja Osberghaus, Alexandra Baumann, Paul Schnitzler, Martin Zeier, Ellen Krautkrämer
BACKGROUND: Hantavirus disease is characterized by endothelial dysfunction. Angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) play a key role in the control of capillary permeability. Ang-1 is responsible for maintenance of cell-to-cell contacts whereas Ang-2 destabilizes monolayers. An imbalance of Ang-1 and Ang-2 levels results in enhanced permeability and capillary leakage. OBJECTIVES: To analyze the involvement of angiopoietins in hantavirus-induced disruption of endothelia, we measured the levels of Ang-1 and Ang-2 in hantavirus infection...
September 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28664467/phylogenetic-analysis-of-puumala-virus-strains-from-central-europe-highlights-the-need-for-a-full-genome-perspective-on-hantavirus-evolution
#17
Róbert Szabó, Lukáš Radosa, Martina Ličková, Monika Sláviková, Marta Heroldová, Michal Stanko, Milan Pejčoch, Anja Osterberg, Lies Laenen, Susanne Schex, Rainer G Ulrich, Sandra Essbauer, Piet Maes, Boris Klempa
Puumala virus (PUUV), carried by bank voles (Myodes glareolus), is the medically most important hantavirus in Central and Western Europe. In this study, a total of 523 bank voles (408 from Germany, 72 from Slovakia, and 43 from Czech Republic) collected between the years 2007-2012 were analyzed for the presence of hantavirus RNA. Partial PUUV genome segment sequences were obtained from 51 voles. Phylogenetic analyses of all three genome segments showed that the newfound strains cluster with other Central and Western European PUUV strains...
December 2017: Virus Genes
https://www.readbyqxmd.com/read/28585306/circulation-and-diagnostics-of-puumala-virus-in-norway-nephropatia-epidemica-incidence-and-rodent-population-dynamics
#18
Natacha Milhano, Lars Korslund, Magnus Evander, Clas Ahlm, Kirsti Vainio, Susanne G Dudman, Åshild Andreassen
Hantaviruses pose a public health concern worldwide causing haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Puumala virus (PUUV) is the most prevalent hantavirus in Central and Northern Europe, and causes a mild form of HFRS, also known as nephropathia epidemica (NE). In nature, the main host of PUUV is the bank vole (Myodes glareolus), and transmission to humans occurs through inhalation of aerosols from rodent excreta. Nephropathia epidemica is particularly prevalent in Nordic countries, however, few studies of PUUV have been performed in Norway...
August 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28567209/modelling-human-puumala-hantavirus-infection-in-relation-to-bank-vole-abundance-and-masting-intensity-in-the-netherlands
#19
Arno Swart, Dick L Bekker, Miriam Maas, Ankje de Vries, Roan Pijnacker, Chantal B E M Reusken, Joke W B van der Giessen
This paper deals with modelling the relationship between human Puumala hantavirus (PUUV) infection, the abundance and prevalence of infection of the host (the bank vole), mast, and temperature. These data were used to build and parametrise generalised regression models, and parametrise them using datasets on these factors pertaining to the Netherlands. The performance of the models was assessed by considering their predictive power. Models including mast and monthly temperature performed well, and showed that mast intensity influences vole abundance and hence human exposure for the following year...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/28396283/experimental-infections-of-wild-bank-voles-myodes-glareolus-from-nephropatia-epidemica-endemic-and-non-endemic-regions-revealed-slight-differences-in-puumala-virological-course-and-immunological-responses
#20
Adélaïde Dubois, Guillaume Castel, Séverine Murri, Coralie Pulido, Jean-Baptiste Pons, Laure Benoit, Anne Loiseau, Latifa Lakhdar, Maxime Galan, Nathalie Charbonnel, Philippe Marianneau
In Europe, the occurrence of nephropathia epidemica (NE), a human disease caused by Puumala virus (PUUV), exhibits considerable geographical heterogeneity despite the continuous distribution of its reservoir, the bank vole Myodes glareolus. To better understand the causes of this heterogeneity, wild voles sampled in two adjacent NE endemic and non-endemic regions of France were infected experimentally with PUUV. The responses of bank voles to PUUV infection, based on the levels of anti-PUUV IgG and viral RNA, were compared...
May 2, 2017: Virus Research
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