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https://www.readbyqxmd.com/read/28943870/gastrointestinal-tract-as-entry-route-for-hantavirus-infection
#1
Peter T Witkowski, Casey C Perley, Rebecca L Brocato, Jay W Hooper, Christian Jürgensen, Jörg-Dieter Schulzke, Detlev H Krüger, Roland Bücker
Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and are thought to be transmitted to humans by exposure to aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe. A large proportion of PUUV-infected patients suffer from gastrointestinal symptoms of unclear origin. In this study we demonstrate that PUUV infection can occur via the alimentary tract. Methods: We investigated susceptibility of the human small intestinal epithelium for PUUV infection and analyzed the resistance of virions to gastric juice...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28943728/short-peptide-epitope-design-from-hantaviruses-causing-hfrs
#2
Sathish Sankar, Mageshbabu Ramamurthy, Balaji Nandagopal, Gopalan Sridharan
Several genotypes of the hantavirus cause hemorrhagic fever with renal syndrome (HFRS) and is an important public health problem worldwide. There is now growing interest to develop subunit vaccines especially focused to elicit cytotoxic T lymphocyte responses which are important against viral infection. We identified candidate T-cell epitopes that bind to Class I HLA supertypes towards identifying potential subunit vaccine entity. These epitopes are conserved in all 5 hantavirus genotypes of HFRS (Hantaan, Dobrava- Belgrade, Seoul, Gou virus and Amur)...
2017: Bioinformation
https://www.readbyqxmd.com/read/28931451/bank-vole-immunoheterogeneity-may-limit-nephropatia-epidemica-emergence-in-a-french-non-endemic-region
#3
A Dubois, G Castel, S Murri, C Pulido, J-B Pons, L Benoit, A Loiseau, L Lakhdar, M Galan, P Marianneau, N Charbonnel
Ecoevolutionary processes affecting hosts, vectors and pathogens are important drivers of zoonotic disease emergence. In this study, we focused on nephropathia epidemica (NE), which is caused by Puumala hantavirus (PUUV) whose natural reservoir is the bank vole, Myodes glareolus. We questioned the possibility of NE emergence in a French region that is considered to be NE-free but that is adjacent to a NE-endemic region. We first confirmed the epidemiology of these two regions and we demonstrated the absence of spatial barriers that could have limited dispersal, and consequently, the spread of PUUV into the NE-free region...
September 21, 2017: Parasitology
https://www.readbyqxmd.com/read/28930019/hantavirus-pulmonary-syndrome-caused-by-maripa-virus-in-french-guiana-2008-2016
#4
Séverine Matheus, Hatem Kallel, Claire Mayence, Laetitia Bremand, Stéphanie Houcke, Dominique Rousset, Vincent Lacoste, Benoit de Thoisy, Didier Hommel, Anne Lavergne
We report 5 human cases of hantavirus pulmonary syndrome found during surveillance in French Guiana in 2008-2016; of the 5 patients, 4 died. This pathogen should continue to be monitored in humans and rodents in effort to reduce the occurrence of these lethal infections in humans stemming from ecosystem disturbances.
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28904194/a-distinct-mechanism-for-the-formation-of-the-ribonucleoprotein-complex-of-the-tomato-spotted-wilt-virus
#5
Yu Guo, Baocheng Liu, Zhenzhen Ding, Guobang Li, Meizi Liu, Dantong Zhu, Yuna Sun, Shishang Dong, Zhiyong Lou
The tomato spotted wilt virus (TSWV) belongs to the Tospovirus genus of the Bunyaviridae family and represents the sole plant-infecting group within bunyavirus. TSWV encodes a nucleocapsid protein (N) which encapsidates the RNA genome to form a ribonucleoprotein complex (RNP). In addition, the N has multiple roles during the infection of plant cells. Here, we report the crystal structure of the full-length TSWV N. The N features a body domain consisting of an N- and C-lobe. These lobes clamp a positively charged groove which may constitute the RNA binding site...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28895058/a-neuropathic-pain-syndrome-associated-with-hantavirus-infection
#6
Dustin Anderson, Grayson Beecher, Christopher Power, Lindsay Bridgland, Douglas W Zochodne
Hantaviruses are a group of single-stranded RNA viruses of the Bunyaviridae family. "New World" hantaviruses cause hantavirus cardiopulmonary syndrome (HCPS) in North America. HCPS carries with it significant mortality and those patients who survive the disease are often left with substantial morbidity. Neurologic complications of hantavirus infections are rare, with only sparse cases of central nervous system involvement having been documented in the literature. To our knowledge, there are no reports of hantavirus infection contributing to peripheral nervous system dysfunction...
September 11, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28894346/high-resolution-computed-tomography-findings-in-hantavirus-pulmonary-syndrome
#7
EDITORIAL
Felipe von Ranke
No abstract text is available yet for this article.
July 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28873024/serological-survey-of-zoonotic-viruses-in-invasive-and-native-commensal-rodents-in-senegal-west-africa
#8
Christophe A Diagne, Nathalie Charbonnel, Heikki Henttonen, Tarja Sironen, Carine Brouat
Increasing studies on rodent-borne diseases still highlight the major role of rodents as reservoirs of numerous zoonoses of which the frequency is likely to increase worldwide as a result of accelerated anthropogenic changes, including biological invasions. Such a situation makes pathogen detection in rodent populations important, especially in the context of developing countries characterized by high infectious disease burden. Here, we used indirect fluorescent antibody tests to describe the circulation of potentially zoonotic viruses in both invasive (Mus musculus domesticus and Rattus rattus) and native (Mastomys erythroleucus and Mastomys natalensis) murine rodent populations in Senegal (West Africa)...
September 5, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28856421/co-circulation-of-araraquara-and-juquitiba-hantavirus-in-brazilian-cerrado
#9
Alexandro Guterres, Renata Carvalho de Oliveira, Jorlan Fernandes, Renata Malachini Maia, Bernardo Rodrigues Teixeira, Flávio César Gomes Oliveira, Cibele Rodrigues Bonvicino, Paulo Sergio D'Andrea, Carlos Guerra Schrago, Elba Regina Sampaio de Lemos
Hantavirus cardiopulmonary syndrome is an emerging serious disease in the Americas, transmitted from wild rodents to humans through inhalation of aerosol containing virus. Herein, we characterized two distinct hantaviruses circulating in rodent species form Central Plateau, Midwestern region of Brazil in the Cerrado (savanna-like) biome, an area characterized by small trees and grasses adapted to climates with long dry periods. In this study, we identified the co-circulation of the Araraquara virus and a possible new lineage of the Juquitiba virus (JUQV) in Oligoryzomys nigripes...
August 31, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28835498/structural-transitions-of-the-conserved-and-metastable-hantaviral-glycoprotein-envelope
#10
Ilona Rissanen, Robert Stass, Antra Zeltina, Sai Li, Jussi Hepojoki, Karl Harlos, Robert J C Gilbert, Juha T Huiskonen, Thomas A Bowden
Hantaviruses are zoonotic pathogens with a near-global distribution that can cause severe hemorrhagic fever and pulmonary syndrome. The outer membrane of the hantavirus envelope displays a lattice of two glycoproteins, Gn and Gc, which orchestrate host cell recognition and entry. Here, we describe the crystal structure of the Gn glycoprotein ectodomain from the Asiatic Hantaan virus (HTNV), the most prevalent pathogenic hantavirus. Structural overlay analysis reveals that the HTNV Gn fold is highly similar to the Gn of Puumala virus (PUUV), a genetically and geographically distinct and less pathogenic hantavirus found predominantly in North-Eastern Europe, confirming that the hantaviral Gn fold is architecturally conserved across hantavirus clades...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28835374/low-affinity-binding-in-cis-to-p2y2r-mediates-force-dependent-integrin-activation-during-hantavirus-infection
#11
Virginie Bondu, Chenyu Wu, Wenpeng Cao, Peter C Simons, Jennifer Gillette, Jieqing Zhu, Laurie Erb, X Frank Zhang, Tione Buranda
Pathogenic hantaviruses bind to the Plexin Semaphorin Integrin (PSI) domain of inactive, β3 integrins. Previous studies have implicated a cognate cis interaction between the bent conformation β5/β3 integrins and an RGD sequence in the first extracellular loop of P2Y2R (Erb et al., 2001). With single-molecule atomic force microscopy, we show a cognate interaction between (RGD)P2Y2R and an AFM tip decorated with recombinant αIIbβ3 integrins expressed on cell membranes. Mutation of the RGD sequence to RGE in the P2Y2R removes this interaction...
August 23, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28815001/serogrouping-and-seroepidemiology-of-north-european-hantaviruses-using-a-novel-broadly-targeted-synthetic-nucleoprotein-antigen-array
#12
Bengt Rönnberg, Olli Vapalahti, Marco Goeijenbier, Chantal Reusken, Åke Gustafsson, Jonas Blomberg, Åke Lundkvist
Introduction: Hantaviruses are globally distributed zoonotic pathogens. Great diversity and high antigenic cross-reactivity makes diagnosis by traditional methods cumbersome. Materials and methods: 'Megapeptides', 119-120-mers from the amino terminus of the nucleoprotein of 16 hantaviruses, representing the four major branches of the hantavirus phylogenetic tree, were utilized in a novel IgG-based hantavirus suspension multiplex immunoassay (HSMIA) for detection of past hantavirus infections in 155 North European human samples...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/28804005/performance-assessment-of-the-saps-ii-and-sofa-scoring-systems-in-hanta-virus-hemorrhagic-fever-with-renal-syndrome
#13
Zhenjun Yu, Ni Zhou, Ali Li, Jie Chen, Huazhong Chen, Zebao He, Fei Yan, Haihong Zhao, Jiansheng Zhu
BACKGROUND: Hemorrhagic Fever with Renal Syndrome (HFRS), caused by the hantavirus, is a natural infectious disease characterized by fever, hemorrhage and renal damage. China is the most severely endemic area for HFRS in the world. In recent years, critical scoring systems based on quantitative classification have become an important clinical tool for predicting and evaluating the prognosis of critical illness, and provide guidelines for clinical practice. METHODS: The sample comprised 384 patients with HFRS treated in the Taizhou Hospital from January 2006 to February 2017...
August 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28794221/revised-time-scales-of-rna-virus-evolution-based-on-spatial-information
#14
Moritz Saxenhofer, Vanessa Weber de Melo, Rainer G Ulrich, Gerald Heckel
The time scales of pathogen evolution are of major concern in the context of public and veterinary health, epidemiology and evolutionary biology. Dating the emergence of a pathogen often relies on estimates of evolutionary rates derived from nucleotide sequence data. For many viruses, this has yielded estimates of evolutionary origins only a few hundred years in the past. Here we demonstrate through the incorporation of geographical information from virus sampling that evolutionary age estimates of two European hantaviruses are severely underestimated because of pervasive mutational saturation of nucleotide sequences...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28762841/haematuria-is-a-marker-for-the-severity-of-acute-kidney-injury-but-does-not-associate-with-thrombocytopenia-in-acute-puumala-hantavirus-infection
#15
Tuula K Outinen, Paula Mantula, Outi K Laine, Ilkka Pörsti, Antti Vaheri, Satu M Mäkelä, Jukka Mustonen
BACKGROUND: Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome characterized by thrombocytopenia, capillary leakage and acute kidney injury (AKI) with proteinuria and haematuria. Although the typical histologic lesion is acute tubulointerstitial nephritis, the amount of glomerular proteinuria predicts the severity of upcoming AKI. Here, we studied the associations of haematuria and proteinuria with the severity of emerging AKI, thrombocytopenia and markers of coagulation and fibrinolysis in PUUV infection...
August 1, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28747170/spatial-prediction-and-validation-of-zoonotic-hazard-through-micro-habitat-properties-where-does-puumala-hantavirus-hole-up
#16
Hussein Khalil, Gert Olsson, Magnus Magnusson, Magnus Evander, Birger Hörnfeldt, Frauke Ecke
BACKGROUND: To predict the risk of infectious diseases originating in wildlife, it is important to identify habitats that allow the co-occurrence of pathogens and their hosts. Puumala hantavirus (PUUV) is a directly-transmitted RNA virus that causes hemorrhagic fever in humans, and is carried and transmitted by the bank vole (Myodes glareolus). In northern Sweden, bank voles undergo 3-4 year population cycles, during which their spatial distribution varies greatly. METHODS: We used boosted regression trees; a technique inspired by machine learning, on a 10 - year time-series (fall 2003-2013) to develop a spatial predictive model assessing seasonal PUUV hazard using micro-habitat variables in a landscape heavily modified by forestry...
July 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28734140/deregulation-of-levels-of-angiopoietin-1-and-angiopoietin-2-is-associated-with-severe-courses-of-hantavirus-infection
#17
Christian Nusshag, Anja Osberghaus, Alexandra Baumann, Paul Schnitzler, Martin Zeier, Ellen Krautkrämer
BACKGROUND: Hantavirus disease is characterized by endothelial dysfunction. Angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) play a key role in the control of capillary permeability. Ang-1 is responsible for maintenance of cell-to-cell contacts whereas Ang-2 destabilizes monolayers. An imbalance of Ang-1 and Ang-2 levels results in enhanced permeability and capillary leakage. OBJECTIVES: To analyze the involvement of angiopoietins in hantavirus-induced disruption of endothelia, we measured the levels of Ang-1 and Ang-2 in hantavirus infection...
July 11, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28727744/climate-change-and-sugarcane-expansion-increase-hantavirus-infection-risk
#18
Paula Ribeiro Prist, María Uriarte, Katia Fernandes, Jean Paul Metzger
Hantavirus Cardiopulmonary Syndrome (HCPS) is a disease caused by Hantavirus, which is highly virulent for humans. High temperatures and conversion of native vegetation to agriculture, particularly sugarcane cultivation can alter abundance of rodent generalist species that serve as the principal reservoir host for HCPS, but our understanding of the compound effects of land use and climate on HCPS incidence remains limited, particularly in tropical regions. Here we rely on a Bayesian model to fill this research gap and to predict the effects of sugarcane expansion and expected changes in temperature on Hantavirus infection risk in the state of São Paulo, Brazil...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28724455/a-seroprevalence-study-to-determine-the-frequency-of-hantavirus-infection-in-people-exposed-to-wild-and-pet-fancy-rats-in-england
#19
J M Duggan, R Close, L McCann, D Wright, M Keys, N McCarthy, T Mannes, A Walsh, A Charlett, T J G Brooks
Recent cases of acute kidney injury due to Seoul hantavirus infection from exposure to wild or pet fancy rats suggest this infection is increasing in prevalence in the UK. We conducted a seroprevalence study in England to estimate cumulative exposure in at-risk groups with contact with domesticated and wild rats to assess risk and inform public health advice. From October 2013 to June 2014, 844 individual blood samples were collected. Hantavirus seroprevalence amongst the pet fancy rat owner group was 34.1% (95% CI 23·9-45·7%) compared with 3·3% (95% CI 1·6-6·0) in a baseline control group, 2·4% in those with occupational exposure to pet fancy rats (95% CI 0·6-5·9) and 1·7% with occupational exposure to wild rats (95% CI 0·2-5·9)...
September 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28721632/detection-and-characterization-of-three-zoonotic-viruses-in-wild-rodents-and-shrews-from-shenzhen-city-china
#20
Bo Wang, Chun-Lin Cai, Bei Li, Wei Zhang, Yan Zhu, Wei-Hong Chen, Fei Zhuo, Zheng-Li Shi, Xing-Lou Yang
Diverse species of rodents and shrews, which are abundant worldwide, harbor a variety of viruses; some of these are closely related to human viruses and possess zoonotic potential. Previously studies have demonstrated that the mammarenavirus and hantavirus carried by rodents or shrews could cause diseases in human population. To determine the distribution of zoonotic viruses in Shenzhen city, the major city in southern China with a high population density, we analyzed 225 rodents (Rattus norvegicus and Rattus flavipectus) and 196 shrews (Suncus murinus) from urban and rural districts for the presence of mammarenavirus, hantavirus, and hepatitis E virus (HEV) by RT-PCR targeting the conserved regions...
August 2017: Virologica Sinica
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