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https://www.readbyqxmd.com/read/28804005/performance-assessment-of-the-saps-ii-and-sofa-scoring-systems-in-hanta-virus-hemorrhagic-fever-with-renal-syndrome
#1
Zhenjun Yu, Ni Zhou, Ali Li, Jie Chen, Huazhong Chen, Zebao He, Fei Yan, Haihong Zhao, Jiansheng Zhu
BACKGROUND: Hemorrhagic Fever with Renal Syndrome (HFRS), caused by the hantavirus, is a natural infectious disease characterized by fever, hemorrhage and renal damage. China is the most severely endemic area for HFRS in the world. In recent years, critical scoring systems based on quantitative classification have become an important clinical tool for predicting and evaluating the prognosis of critical illness, and provide guidelines for clinical practice. METHODS: The sample comprised 384 patients with HFRS treated in the Taizhou Hospital from January 2006 to February 2017...
August 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28794221/revised-time-scales-of-rna-virus-evolution-based-on-spatial-information
#2
Moritz Saxenhofer, Vanessa Weber de Melo, Rainer G Ulrich, Gerald Heckel
The time scales of pathogen evolution are of major concern in the context of public and veterinary health, epidemiology and evolutionary biology. Dating the emergence of a pathogen often relies on estimates of evolutionary rates derived from nucleotide sequence data. For many viruses, this has yielded estimates of evolutionary origins only a few hundred years in the past. Here we demonstrate through the incorporation of geographical information from virus sampling that evolutionary age estimates of two European hantaviruses are severely underestimated because of pervasive mutational saturation of nucleotide sequences...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28762841/haematuria-is-a-marker-for-the-severity-of-acute-kidney-injury-but-does-not-associate-with-thrombocytopenia-in-acute-puumala-hantavirus-infection
#3
Tuula K Outinen, Paula Mantula, Outi K Laine, Ilkka Pörsti, Antti Vaheri, Satu M Mäkelä, Jukka Mustonen
BACKGROUND: Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome characterized by thrombocytopenia, capillary leakage and acute kidney injury (AKI) with proteinuria and haematuria. Although the typical histologic lesion is acute tubulointerstitial nephritis, the amount of glomerular proteinuria predicts the severity of upcoming AKI. Here, we studied the associations of haematuria and proteinuria with the severity of emerging AKI, thrombocytopenia and markers of coagulation and fibrinolysis in PUUV infection...
August 1, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28747170/spatial-prediction-and-validation-of-zoonotic-hazard-through-micro-habitat-properties-where-does-puumala-hantavirus-hole-up
#4
Hussein Khalil, Gert Olsson, Magnus Magnusson, Magnus Evander, Birger Hörnfeldt, Frauke Ecke
BACKGROUND: To predict the risk of infectious diseases originating in wildlife, it is important to identify habitats that allow the co-occurrence of pathogens and their hosts. Puumala hantavirus (PUUV) is a directly-transmitted RNA virus that causes hemorrhagic fever in humans, and is carried and transmitted by the bank vole (Myodes glareolus). In northern Sweden, bank voles undergo 3-4 year population cycles, during which their spatial distribution varies greatly. METHODS: We used boosted regression trees; a technique inspired by machine learning, on a 10 - year time-series (fall 2003-2013) to develop a spatial predictive model assessing seasonal PUUV hazard using micro-habitat variables in a landscape heavily modified by forestry...
July 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28734140/deregulation-of-levels-of-angiopoietin-1-and-angiopoietin-2-is-associated-with-severe-courses-of-hantavirus-infection
#5
Christian Nusshag, Anja Osberghaus, Alexandra Baumann, Paul Schnitzler, Martin Zeier, Ellen Krautkrämer
BACKGROUND: Hantavirus disease is characterized by endothelial dysfunction. Angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) play a key role in the control of capillary permeability. Ang-1 is responsible for maintenance of cell-to-cell contacts whereas Ang-2 destabilizes monolayers. An imbalance of Ang-1 and Ang-2 levels results in enhanced permeability and capillary leakage. OBJECTIVES: To analyze the involvement of angiopoietins in hantavirus-induced disruption of endothelia, we measured the levels of Ang-1 and Ang-2 in hantavirus infection...
July 11, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28727744/climate-change-and-sugarcane-expansion-increase-hantavirus-infection-risk
#6
Paula Ribeiro Prist, María Uriarte, Katia Fernandes, Jean Paul Metzger
Hantavirus Cardiopulmonary Syndrome (HCPS) is a disease caused by Hantavirus, which is highly virulent for humans. High temperatures and conversion of native vegetation to agriculture, particularly sugarcane cultivation can alter abundance of rodent generalist species that serve as the principal reservoir host for HCPS, but our understanding of the compound effects of land use and climate on HCPS incidence remains limited, particularly in tropical regions. Here we rely on a Bayesian model to fill this research gap and to predict the effects of sugarcane expansion and expected changes in temperature on Hantavirus infection risk in the state of São Paulo, Brazil...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28724455/a-seroprevalence-study-to-determine-the-frequency-of-hantavirus-infection-in-people-exposed-to-wild-and-pet-fancy-rats-in-england
#7
J M Duggan, R Close, L McCann, D Wright, M Keys, N McCarthy, T Mannes, A Walsh, A Charlett, T J G Brooks
Recent cases of acute kidney injury due to Seoul hantavirus infection from exposure to wild or pet fancy rats suggest this infection is increasing in prevalence in the UK. We conducted a seroprevalence study in England to estimate cumulative exposure in at-risk groups with contact with domesticated and wild rats to assess risk and inform public health advice. From October 2013 to June 2014, 844 individual blood samples were collected. Hantavirus seroprevalence amongst the pet fancy rat owner group was 34.1% (95% CI 23·9-45·7%) compared with 3·3% (95% CI 1·6-6·0) in a baseline control group, 2·4% in those with occupational exposure to pet fancy rats (95% CI 0·6-5·9) and 1·7% with occupational exposure to wild rats (95% CI 0·2-5·9)...
September 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28721632/detection-and-characterization-of-three-zoonotic-viruses-in-wild-rodents-and-shrews-from-shenzhen-city-china
#8
Bo Wang, Chun-Lin Cai, Bei Li, Wei Zhang, Yan Zhu, Wei-Hong Chen, Fei Zhuo, Zheng-Li Shi, Xing-Lou Yang
Diverse species of rodents and shrews, which are abundant worldwide, harbor a variety of viruses; some of these are closely related to human viruses and possess zoonotic potential. Previously studies have demonstrated that the mammarenavirus and hantavirus carried by rodents or shrews could cause diseases in human population. To determine the distribution of zoonotic viruses in Shenzhen city, the major city in southern China with a high population density, we analyzed 225 rodents (Rattus norvegicus and Rattus flavipectus) and 196 shrews (Suncus murinus) from urban and rural districts for the presence of mammarenavirus, hantavirus, and hepatitis E virus (HEV) by RT-PCR targeting the conserved regions...
July 17, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28720142/comparison-of-serological-assays-to-titrate-hantaan-and-seoul-hantavirus-specific-antibodies
#9
Weihong Li, Shouchun Cao, Quanfu Zhang, Jiandong Li, Shuo Zhang, Wei Wu, Jing Qu, Chuan Li, Mifang Liang, Dexin Li
BACKGROUND: Hantaan and Seoul viruses, in the Hantavirus genus, are known to cause hemorrhagic fever with renal syndrome (HFRS). The plaque reduction neutralization test (PRNT), as conventional neutralization test for hantaviruses, is laborious and time-consuming. Alternatives to PRNT for hantaviruses are required. METHODS: In this study, the methods for Hantaan and Seoul viruses serological typing including microneutralization test (MNT), pseudoparticle neutralization test (PPNT) and immunofluorescence assay based on viral glycoproteins (IFA-GP) were developed and compared with PRNT using a panel of 74 sera including 44 convalescent sera of laboratory confirmed HFRS patients and 30 patients sera of non-hantavirus infection...
July 18, 2017: Virology Journal
https://www.readbyqxmd.com/read/28719302/a-fatal-hantavirus-pulmonary-syndrome-misdiagnosed-as-dengue-an-investigation-into-the-first-reported-case-in-rio-de-janeiro-state-brazil
#10
Renata Carvalho de Oliveira, Alexandro Guterres, Bernardo Rodrigues Teixeira, Jorlan Fernandes, João Marcos Penna Júnior, Reynaldo de Jesus Oliveira Júnior, Liana Strecht Pereira, João Bosco Júnior, Patrícia Soares Meneguete, Cristina Maria Giordano Dias, Cibele Rodrigues Bonvicino, Paulo Sérgio D'Andrea, Elba Regina Sampaio de Lemos
We report the results of an investigation into a fatal case of hantavirus pulmonary syndrome (HPS) in Rio de Janeiro State, Brazil, where the disease had not been reported previous to 2015. Following the notification of an HPS case, serum samples were collected from the household members and work contacts of the HPS patient and tested for antibody to hantaviruses. Seroprevalence of 22% (10/45) was indicated for hantavirus out of 45 human samples tested. Blood and tissue samples were collected from 72 rodents during fieldwork to evaluate the prevalence of hantavirus infection, by using enzyme-linked immunosorbent assay IgG, and to characterize the rodent hantavirus reservoir(s), by reverse transcription polymerase chain reaction and sequencing...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28714801/muleshoe-virus-and-other-hantaviruses-associated-with-neotomine-or-sigmodontine-rodents-in-texas
#11
Mary Louise Milazzo, Maria N B Cajimat, Martin H Richter, Robert D Bradley, Charles F Fulhorst
The broad objective of this study was to increase our knowledge of Muleshoe virus and other hantaviruses associated with cricetid rodents in Texas. Anti-hantavirus antibody was found in 38 (3.2%) of 1171 neotomine rodents and 6 (1.8%) of 332 sigmodontine rodents from 10 Texas counties; hantaviral RNA was detected in 23 (71.9%) of 32 antibody-positive rodents. Analyses of nucleocapsid protein gene sequences indicated Muleshoe virus infection in four hispid cotton rats (Sigmodon hispidus) from northern Texas; Bayou virus, three Texas marsh oryzomys (Oryzomys texensis) from the Gulf Coast; Limestone Canyon virus, five brush mice (Peromyscus boylii) from western Texas; and Sin Nombre virus-five Texas mice (P...
July 17, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28708900/serum-levels-of-interleukin-6-are-linked-to-the-severity-of-the-disease-caused-by-andes-virus
#12
Jenniffer Angulo, Constanza Martínez-Valdebenito, Claudia Marco, Héctor Galeno, Eliecer Villagra, Lilian Vera, Natalia Lagos, Natalia Becerra, Judith Mora, Andrea Bermúdez, Janepsy Díaz, Marcela Ferrés, Marcelo López-Lastra
Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circulating cytokines were determined by a Bead-Based Multiplex assay coupled with Luminex detection technology, in order to compare 43 serum samples of healthy controls and 43 samples of ANDV-infected patients that had been categorized according to the severity of disease...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28703073/persistence-of-immune-responses-to-vaccine-against-haemorrhagic-fever-with-renal-syndrome-in-healthy-adults-aged-16-60-years-results-from-an-open-label2-year-follow-up-study
#13
Yuan Zheng, Bu-Yu Zhou, Jing Wei, Yi Xu, Jian-Hua Dong, Lu-Yuan Guan, Ping Ma, Peng-Bo Yu, Jing-Jun Wang
BACKGROUND: Approximately 2 million doses of vaccine against haemorrhagic fever with renal syndrome (HFRS) have been used annually in China. However, there were limited studies focused on persistence of immune responses to HFRS vaccine in healthy adults. A phase 4, multicentre, open trial has been undertaken to assess antibody persistence after HFRS vaccination of healthy adolescents and adults aged 16-60 years. METHODS: The vaccine was administered as a three-dose series at 0, 2 weeks and 6 months, including two primary doses and one booster dose...
July 13, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28696305/interannual-cycles-of-hantaan-virus-outbreaks-at-the-human-animal-interface-in-central-china-are-controlled-by-temperature-and-rainfall
#14
Huaiyu Tian, Pengbo Yu, Bernard Cazelles, Lei Xu, Hua Tan, Jing Yang, Shanqian Huang, Bo Xu, Jun Cai, Chaofeng Ma, Jing Wei, Shen Li, Jianhui Qu, Marko Laine, Jingjun Wang, Shilu Tong, Nils Chr Stenseth, Bing Xu
Hantavirus, a rodent-borne zoonotic pathogen, has a global distribution with 200,000 human infections diagnosed annually. In recent decades, repeated outbreaks of hantavirus infections have been reported in Eurasia and America. These outbreaks have led to public concern and an interest in understanding the underlying biological mechanisms. Here, we propose a climate-animal-Hantaan virus (HTNV) infection model to address this issue, using a unique dataset spanning a 54-y period (1960-2013). This dataset comes from Central China, a focal point for natural HTNV infection, and includes both field surveillance and an epidemiological record...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28685549/analysis-of-hemorrhagic-fever-with-renal-syndrome-and-its-pathogenic-gene-sequence-based-on-geographic-information-system
#15
Z Tang, X J Xu, X J He, Z S Liang, W B Liang, Y Li, K Gao
This study analyzed the temporal-spatial distribution characteristics, epidemiological characteristics and gene sequences of hemorrhagic fever with renal syndrome (HFRS) in Guangxi, with the intention of providing a theoretical and technical support for the prevention of HFRS. A map of the incidence of HFRS of different cities in Guangxi was drawn up using the Geographic Information System (GIS) to investigate the epidemiological characteristics and infection source of HFRS between 2013 and 2016. Guangxi has a low incidence of HFRS, and autumn and winter are the main high-incidence seasons...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28681802/globally-emerging-hantaviruses-an-overview
#16
REVIEW
Sara Chandy, Dilip Mathai
Hantaviruses are known to cause haemorrhagic fever with renal syndrome in Eurasia and hantavirus cardiopulmonary syndrome in the Americas. They are globally emerging pathogens as newer serotypes are routinely being reported. This review discusses hantavirus biology, clinical features and pathogenesis of hantavirus disease, its diagnostics, distribution and mammalian hosts. Hantavirus research in India is also summarised.
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28678679/hantavirus-rna-prevalence-in-myomorph-rodents-on-bolshoy-ussuriysky-island-at-the-sino-russian-border
#17
Tingting Lu, Yingqun Fu, Yong Hou, Yu Yang, Lijuan Liu, Huijie Liang, Jun Yang, Dan Jiao, Changqing Ying
OBJECTIVE: To understand the distribution and infection status of hantavirus in Myomorph rodents on Bolshoy Ussuriysky Island (Heixiazi Island) at the Sino-Russian border, and to provide data for the safe development and utilization of Bolshoy Ussuriysky Island. METHODS: In 2013 and 2014, Myomorph rodents were trapped on Bolshoy Ussuriysky Island. Total RNA was extracted from rodent tissue, and it was screened for hantavirus RNA by using reverse transcription-polymerase chain reaction...
August 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28676847/in-cell-western-assays-to-evaluate-hantaan-virus-replication-as-a-novel-approach-to-screen-antiviral-molecules-and-detect-neutralizing-antibody-titers
#18
Hong-Wei Ma, Wei Ye, He-Song Chen, Tie-Jian Nie, Lin-Feng Cheng, Liang Zhang, Pei-Jun Han, Xing-An Wu, Zhi-Kai Xu, Ying-Feng Lei, Fang-Lin Zhang
Hantaviruses encompass rodent-borne zoonotic pathogens that cause severe hemorrhagic fever disease with high mortality rates in humans. Detection of infectious virus titer lays a solid foundation for virology and immunology researches. Canonical methods to assess viral titers rely on visible cytopathic effects (CPE), but Hantaan virus (HTNV, the prototype hantavirus) maintains a relatively sluggish life cycle and does not produce CPE in cell culture. Here, an in-cell Western (ICW) assay was utilized to rapidly measure the expression of viral proteins in infected cells and to establish a novel approach to detect viral titers...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28670025/high-resolution-computed-tomography-findings-in-eight-patients-with-hantavirus-pulmonary-syndrome
#19
Diego de Lacerda Barbosa, Bruno Hochhegger, Arthur Soares Souza, Gláucia Zanetti, Dante Luiz Escuissato, Gustavo de Souza Portes Meirelles, Marcelo Buarque de Gusmão Funari, Edson Marchiori
OBJECTIVE: The purpose of this study was to describe the high-resolution computed tomography (HRCT) findings in patients with hantavirus pulmonary syndrome (HPS). MATERIALS AND METHODS: We retrospectively reviewed HRCT findings from eight cases of HPS. All patients were men, aged 19-70 (mean, 41.7) years. Diagnoses were established by serological test (enzyme-linked immunosorbent assay) in all patients. Two chest radiologists analyzed the images and reached decisions by consensus...
May 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28664467/phylogenetic-analysis-of-puumala-virus-strains-from-central-europe-highlights-the-need-for-a-full-genome-perspective-on-hantavirus-evolution
#20
Róbert Szabó, Lukáš Radosa, Martina Ličková, Monika Sláviková, Marta Heroldová, Michal Stanko, Milan Pejčoch, Anja Osterberg, Lies Laenen, Susanne Schex, Rainer G Ulrich, Sandra Essbauer, Piet Maes, Boris Klempa
Puumala virus (PUUV), carried by bank voles (Myodes glareolus), is the medically most important hantavirus in Central and Western Europe. In this study, a total of 523 bank voles (408 from Germany, 72 from Slovakia, and 43 from Czech Republic) collected between the years 2007-2012 were analyzed for the presence of hantavirus RNA. Partial PUUV genome segment sequences were obtained from 51 voles. Phylogenetic analyses of all three genome segments showed that the newfound strains cluster with other Central and Western European PUUV strains...
June 29, 2017: Virus Genes
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