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Hantavirus

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https://www.readbyqxmd.com/read/29340460/first-serologic-evidence-of-human-hantavirus-infection-in-alagoas-state-in-northeastern-brazil
#1
José Alfredo Dos Santos-Júnior, Flávio Martins Dos Santos, Patrícia Alves Barros, Nedja Poliane Torres Medeiros, Gilberto Sabino-Santos Júnior, Magliones Carneiro de Lima, Luiz Tadeu Moraes Figueiredo, Alessandra Abel Borges
INTRODUCTION: Hantavirus cardiopulmonary syndrome (HCPS) is rare in Northeastern Brazil. METHODS: Prospective surveillance was conducted over a two-year period in Alagoas State, Northeastern Brazil. The prevalence of anti-hantavirus N-antigen IgM and IgG in human serum samples was determined by enzyme-linked immunosorbent assay testing. RESULTS: High avidity IgG was found in nine of 476 serum samples tested (from 102 patients with clinical manifestations compatible with HCPS, 124 patients with leptospirosis, and 250 healthy rural workers)...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29329512/landscape-and-rodent-community-composition-are-associated-with-risk-of-hemorrhagic-fever-with-renal-syndrome-in-two-cities-in-china-2006-2013
#2
Hong Xiao, Xin Tong, Ru Huang, Lidong Gao, Shixiong Hu, Yapin Li, Hongwei Gao, Pai Zheng, Huisuo Yang, Zheng Y X Huang, Hua Tan, Huaiyu Tian
BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by hantaviruses. Landscape can influence the risk of hantavirus infection for humans, mainly through its effect on rodent community composition and distribution. It is important to understand how landscapes influence population dynamics for different rodent species and the subsequent effect on HFRS risk. METHODS: To determine how rodent community composition influenced human hantavirus infection, we monitored rodent communities in the prefecture-level cities of Loudi and Shaoyang, China, from 2006 to 2013...
January 12, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29310747/population-based-seroprevalence-of-puumala-hantavirus-in-finland-smoking-as-a-risk-factor
#3
F Latronico, S Mäki, H Rissanen, J Ollgren, O Lyytikäinen, O Vapalahti, J Sane
Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome in humans, that is an endemic disease in Finland. We estimated the seroprevalence of PUUV in Finland and explored risk factors and disease associations by using unique survey data with health register linkage. A total of 2000 sera from a nationwide health survey from 2011, representative of the adult population, were screened for PUUV IgG by immunofluorescence assay. We performed statistical analysis adjusting for stratified cluster design and taking into account sampling weights...
January 9, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29299286/a-damped-precipitation-driven-bottom-up-model-for-deer-mouse-population-abundance-in-the-northwestern-united-states
#4
Irene L Gorosito, Richard J Douglass
Small-mammal population densities can be regulated by bottom-up (food availability) and top-down (predation) forces. In 1993, an El Niño Southern Oscillation event was followed by a cluster of human hantavirus with pulmonary syndrome in the southwestern United States. An upward trophic cascade hypothesis was proposed as an explanation for the outbreak: Increased plant productivity as a consequence of El Niño precipitations led to an unusual increase in distribution and abundance of deer mice (Peromyscus maniculatus; reservoir host of Sin Nombre virus)...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29281106/delayed-ifn-type-1-induced-antiviral-state-is-a-potential-factor-for-hfrs-severity
#5
Katarina Resman Rus, Miša Korva, Petra Bogovic, Emil Pal, Franc Strle, Tatjana Avšic-Županc
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia. Interferon (IFN) responses play an important role in HFRS pathogenesis and it is known that the early IFNβ response is delayed by pathogenic hantaviruses. The clinical severity of HFRS caused by Dobrava virus (DOBV) and Puumala virus (PUUV) varies greatly and the aim of our study was to determine whether differences in early activation of the IFN type 1-induced antiviral state influence HFRS severity. Peripheral blood mononuclear cells (PBMCs) from healthy donors and HFRS patients were stimulated with DOBV or PUUV and the expression of selected genes was measured...
December 21, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29273568/hantavirus-gc-induces-long-term-immune-protection-via-lamp-targeting-dna-vaccine-strategy
#6
Dong-Bo Jiang, Jin-Peng Zhang, Lin-Feng Cheng, Guan-Wen Zhang, Yun Li, Zi-Chao Li, Zhen-Hua Lu, Zi-Xin Zhang, Yu-Chen Lu, Lian-He Zheng, Fang-Lin Zhang, Kun Yang
Hemorrhagic fever with renal syndrome (HFRS) occurs widely throughout Eurasia. Unfortunately, there is no effective treatment, and prophylaxis remains the best option against the major pathogenic agent, hantaan virus (HTNV), which is an Old World hantavirus. However, the absence of cellular immune responses and immunological memory hampers acceptance of the current inactivated HFRS vaccine. Previous studies revealed that a lysosome-associated membrane protein 1 (LAMP1)-targeting strategy involving a DNA vaccine based on the HTNV glycoprotein Gn successfully conferred long-term immunity, and indicated that further research on Gc, another HTNV antigen, was warranted...
December 19, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29260665/rodent-abundance-and-hantavirus-infection-in-protected-area-east-central-argentina
#7
Malena Maroli, María Victoria Vadell, Paula Padula, Isabel E Gómez Villafañe
We captured 3 hantavirus rodent hosts in Otamendi Natural Reserve, Argentina, during 2007-2012. Hantavirus antibodies were found only in Akodon azarae grass mice, mainly in males and old animals. Higher abundance of this species was associated with warm and rainy weather and high water levels, which peaked after a strong El Niño event.
January 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29215554/pets-purity-and-pollution-why-conventional-models-of-disease-transmission-do-not-work-for-pet-rat-owners
#8
Charlotte Robin, Elizabeth Perkins, Francine Watkins, Robert Christley
In the United Kingdom, following the emergence of Seoul hantavirus in pet rat owners in 2012, public health authorities tried to communicate the risk of this zoonotic disease, but had limited success. To explore this lack of engagement with health advice, we conducted in-depth, semi-structured interviews with pet rat owners and analysed them using a grounded theory approach. The findings from these interviews suggest that rat owners construct their pets as different from wild rats, and by elevating the rat to the status of a pet, the powerful associations that rats have with dirt and disease are removed...
December 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29196828/space-use-and-social-mating-system-of-the-hantavirus-host-oligoryzomys-longicaudatus
#9
Ernesto E Juan, Maria Cecilia Provensal, Andrea R Steinmann
The long-tailed mouse, Oligoryzomys longicaudatus (Cricetidae: Sigmodontinae), is the major host of Andes hantavirus, the etiological agent of hantavirus pulmonary syndrome in the south of Argentina and Chile. Studying the ecology of this species is necessary to understand how Andes hantavirus is maintained in nature. In this study, we examine the home range size and intra- and intersexual overlap degree of male and female O. longicaudatus in order to elucidate the mating system of this species. To our knowledge, this research provides the first documentation, obtained from a specific design, of spacing and mating systems in this species in Argentina...
December 1, 2017: EcoHealth
https://www.readbyqxmd.com/read/29184158/meteorological-factors-affect-the-epidemiology-of-hemorrhagic-fever-with-renal-syndrome-via-altering-the-breeding-and-hantavirus-carrying-states-of-rodents-and-mites-a-9-years-longitudinal-study
#10
Fachun Jiang, Ling Wang, Shuo Wang, Lin Zhu, Liyan Dong, Zhentang Zhang, Bi Hao, Fan Yang, Wenbin Liu, Yang Deng, Yun Zhang, Yajun Ma, Bei Pan, Yalin Han, Hongyan Ren, Guangwen Cao
The incidence of hemorrhagic fever with renal syndrome (HFRS) in Qingdao, China was three times higher than that of the average national level. Here we characterized the epidemiology, ecological determinants and pathogen evolution of HFRS in Qingdao during 2007-2015. In this longitudinal study, a total of 1846 HFRS patients and 41 HFRS-related deaths were reported. HFRS in Qingdao peaked once a year in the fourth quarter. We built a time series generalized additive model, and found that meteorological factors in the previous quarter could accurately predict HFRS occurrence...
November 29, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29183085/pet-rats-infect-daughter-mother-with-hantavirus
#11
Rita Rubin
No abstract text is available yet for this article.
November 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29161828/numerical-solution-of-a-spatio-temporal-gender-structured-model-for-hantavirus-infection-in-rodents
#12
Raimund Bürger, Gerardo Chowell, Elvis Gavilán, Pep Mulet, Luis M Villada
In this article we describe the transmission dynamics of hantavirus in rodents using a spatio-temporal susceptible-exposed-infective-recovered (SEIR) compartmental model that distinguishes between male and female subpopulations [L.J.S. Allen, R.K. McCormack and C.B. Jonsson, Bull. Math. Biol. 68 (2006), 511--524]. Both subpopulations are assumed to differ in their movement with respect to local variations in the densities of their own and the opposite gender group. Three alternative models for the movement of the male individuals are examined...
February 1, 2018: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/29159494/the-nucleocapsid-protein-of-hantaviruses-much-more-than-a-genome-wrapping-protein
#13
REVIEW
Monika Reuter, Detlev H Krüger
The nucleocapsid (N) protein of hantaviruses represents an impressive example of a viral multifunctional protein. It encompasses properties as diverse as genome packaging, RNA chaperoning, intracellular protein transport, DNA degradation, intervention in host translation, and restricting host immune responses. These functions all rely on the capability of N to interact with RNA and other viral and cellular proteins. We have compiled data on the N protein of different hantavirus species together with information of the recently published three-dimensional structural data of the protein...
November 20, 2017: Virus Genes
https://www.readbyqxmd.com/read/29141047/is-species-richness-driving-intra-and-interspecific-interactions-and-temporal-activity-overlap-of-a-hantavirus-host-an-experimental-test
#14
André V Rubio, Ivan Castro-Arellano, James N Mills, Rurik List, Rafael Ávila-Flores, Gerardo Suzán
High species diversity of the potential animal host community for a zoonotic pathogen may reduce pathogen transmission among the most competent host, a phenomenon called the "dilution effect", but the mechanisms driving this effect have been little studied. One proposed mechanism is "encounter reduction" where host species of low-competency decrease contact rates between infected and susceptible competent hosts, especially in directly transmitted diseases. We conducted an experiment in outdoor enclosures in northwestern Mexico where we manipulated rodent assemblages to assess the effect of species richness on the frequency of intra- and interspecific interactions and activity patterns of a hantavirus reservoir host (North American deermouse; Peromyscus maniculatus)...
2017: PloS One
https://www.readbyqxmd.com/read/29133028/evolution-and-postglacial-colonization-of-seewis-hantavirus-with-sorex-araneus-in-finland
#15
Jiaxin Ling, Teemu Smura, Daniel Tamarit, Otso Huitu, Liina Voutilainen, Heikki Henttonen, Antti Vaheri, Olli Vapalahti, Tarja Sironen
Hantaviruses have co-existed with their hosts for millions of years. Seewis virus (SWSV), a soricomorph-borne hantavirus, is widespread in Eurasia, ranging from Central Siberia to Western Europe. To gain insight into the phylogeography and evolutionary history of SWSV in Finland, lung tissue samples of 225 common shrews (Sorex araneus) trapped from different parts of Finland were screened for the presence of SWSV RNA. Forty-two of the samples were positive. Partial small (S), medium (M) and large (L) segments of the virus were sequenced, and analyzed together with all SWSV sequences available in Genbank...
November 10, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29129538/pneumonia-in-the-tropics-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#16
REVIEW
Mohd Basri Mat Nor, Guy A Richards, Steve McGloughlin, Pravin R Amin
The aetiology of community acquired pneumonia varies according to the region in which it is acquired. This review discusses those causes of CAP that occur in the tropics and might not be readily recognizable when transplanted to other sites. Various forms of pneumonia including the viral causes such as influenza (seasonal and avian varieties), the coronaviruses and the Hantavirus as well as bacterial causes, specifically the pneumonic form of Yersinia pestis and melioidosis are discussed.
November 3, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29077702/a-lethal-disease-model-for-new-world-hantaviruses-using-immunosuppressed-syrian-hamsters
#17
Valentijn Vergote, Lies Laenen, Bert Vanmechelen, Marc Van Ranst, Erik Verbeken, Jay W Hooper, Piet Maes
BACKGROUND: Hantavirus, the hemorrhagic causative agent of two clinical diseases, is found worldwide with variation in severity, incidence and mortality. The most lethal hantaviruses are found on the American continent where the most prevalent viruses like Andes virus and Sin Nombre virus are known to cause hantavirus pulmonary syndrome. New World hantavirus infection of immunocompetent hamsters results in an asymptomatic infection except for Andes virus and Maporal virus; the only hantaviruses causing a lethal disease in immunocompetent Syrian hamsters mimicking hantavirus pulmonary syndrome in humans...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29070692/the-post-fusion-structure-of-the-heartland-virus-gc-glycoprotein-supports-taxonomic-separation-of-the-bunyaviral-families-phenuiviridae-and-hantaviridae
#18
Yaohua Zhu, Yan Wu, Yan Chai, Jianxun Qi, Ruchao Peng, Wen-Hai Feng, George Fu Gao
Heartland virus (HRTV) is an emerging human pathogen that belongs to the newly defined family Phenuiviridae, order Bunyavirales Gn and Gc are two viral surface glycoproteins encoded by the M segment and are required for early events during infection. HRTV delivers its genome into the cytoplasm by fusion of the viral envelope and endosomal membranes under low pH conditions. Here, we describe the crystal structure of HRTV Gc in its post-fusion conformation. The structure shows that Gc displays a typical class II fusion protein conformation, and the overall structure is identical to severe fever with thrombocytopenia syndrome virus (SFTSV) Gc, which also belongs to the Phenuiviridae family...
October 25, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29063892/hantavirus-and-tuberculosis-co-infection-in-an-indian-child
#19
Someshwar Chate, Ira Shah, Hiren Doshi
Hantaviruses are a group of antigenically distinct viruses carried out in rodents and insectivores. Humans are accidental hosts and get infected by aerosols generated from contaminated urine, faeces and saliva of infected rodents. Hantaviruses are identified as aetiological agents of two human diseases, haemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Hantavirus causing pulmonary renal disease has rarely been reported in children in India. Hantavirus infection is uncommon under the age of 12 years...
July 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29029730/assessing-the-diversity-of-rodent-borne-viruses-exploring-of-high-throughput-sequencing-and-classical-amplification-sequencing-approaches
#20
Stephan Drewes, Petra Straková, Jan F Drexler, Jens Jacob, Rainer G Ulrich
Rodents are distributed throughout the world and interact with humans in many ways. They provide vital ecosystem services, some species are useful models in biomedical research and some are held as pet animals. However, many rodent species can have adverse effects such as damage to crops and stored produce, and they are of health concern because of the transmission of pathogens to humans and livestock. The first rodent viruses were discovered by isolation approaches and resulted in break-through knowledge in immunology, molecular and cell biology, and cancer research...
2017: Advances in Virus Research
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