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https://www.readbyqxmd.com/read/29774860/importation-of-human-seoul-virus-infection-to-germany-from-indonesia
#1
Jörg Hofmann, Sabrina Weiss, Martin Kuhns, Annekathrin Zinke, Heike Heinsberger, Detlev H Kruger
Seoul hantavirus-associated hemorrhagic fever with renal syndrome cases are rare outside Asia and have not yet been found in Germany. We report clinical and molecular evidence for a Seoul virus infection in a patient in Germany. The infection was most likely acquired during a stay in Sulawesi, Indonesia.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29774841/novel-focus-of-sin-nombre-virus-in-peromyscus-eremicus-mice-death-valley-national-park-california-usa
#2
Joseph E Burns, Marco E Metzger, Sharon Messenger, Curtis L Fritz, Inger-Marie E Vilcins, Barryett Enge, Lawrence R Bronson, Vicki L Kramer, Renjie Hu
The deer mouse (Peromyscus maniculatus) is the primary reservoir for Sin Nombre virus (SNV) in the western United States. Rodent surveillance for hantavirus in Death Valley National Park, California, USA, revealed cactus mice (P. eremicus) as a possible focal reservoir for SNV in this location. We identified SNV antibodies in 40% of cactus mice sampled.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29770103/outbreak-of-seoul-virus-among-rats-and-rat-owners-united-states-and-canada-2017
#3
J L Kerins, S E Koske, J Kazmierczak, C Austin, K Gowdy, A Dibernardo
What is already known about this topic?: ​: Seoul virus, a type of hantavirus, is carried by Norway rats. Humans become infected through contact with virus shed in rat urine or droppings, or inhalation of virus particles in dust from contaminated bedding. Infected rats do not develop disease, but humans can experience symptoms ranging from mild influenza-like illness to severe disease with kidney failure and death. Although infections have been previously reported in humans after contact with wild rats, Seoul virus infections had not been reported in pet rats in the United States or Canada...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29765019/relationship-between-circulating-vascular-endothelial-growth-factor-and-its-soluble-receptor-in-patients-with-hemorrhagic-fever-with-renal-syndrome
#4
Emil Pal, Misa Korva, Katarina Resman Rus, Nataša Kejžar, Petra Bogovič, Franc Strle, Tatjana Avšič-Županc
Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2) in HFRS patients infected with Dobrava (DOBV) or Puumala virus (PUUV). VEGF and sVEGFR-2 levels were measured in daily plasma and urine samples of 73 patients with HFRS (58 with PUUV, 15 with DOBV) and evaluated in relation to clinical and laboratory variables...
May 16, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29764527/an-outbreak-of-haemorrhagic-fever-with-renal-syndrome-linked-with-mountain-recreational-activities-in-zagreb-croatia-2017
#5
Z Lovrić, B Kolarić, M L Kosanović Ličina, M Tomljenović, O Đaković Rode, K Danis, B Kaić, V Tešić
In 2017 Zagreb faced the largest outbreak of haemorrhagic fever with renal syndrome (HFRS) to date. We investigated to describe the extent of the outbreak and identify risk factors for infection. We compared laboratory-confirmed cases of Hantavirus infection in Zagreb residents with the onset of illness after 1 January 2017, with individually matched controls from the same household or neighbourhood. We calculated adjusted matched odds ratios (amOR) using conditional logistic regression. During 2017, 104 cases were reported: 11-81 years old (median 37) and 71% (73) male...
May 16, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29751873/acute-viral-hepatitis-beyond-a-b-and-c
#6
REVIEW
Venancio Avancini Ferreira Alves
From the standpoint of the surgical pathologist "hepatitis" is defined as the set of histologic patterns of lesions found in livers infected by hepatotropic viruses, by non-hepatotrophic viruses leading to liver inflammation in the context of systemic infection, or due to an autoimmune disease, drug, or toxin involving the liver. This article is centered on the histologic patterns of injury in acute viral hepatitis, encompassing the hepatotropic viruses A, B, C, D, and E and the "icteric hemorrhagic fevers" (dengue, hantavirus, yellow fever)...
June 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29743115/geographical-distribution-and-relative-risk-of-anjozorobe-virus-thailand-orthohantavirus-infection-in-black-rats-rattus-rattus-in-madagascar
#7
Vololoniaina Raharinosy, Marie-Marie Olive, Fehivola Mandanirina Andriamiarimanana, Soa Fy Andriamandimby, Jean-Pierre Ravalohery, Seta Andriamamonjy, Claudia Filippone, Danielle Aurore Doll Rakoto, Sandra Telfer, Jean-Michel Heraud
BACKGROUND: Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavirus (THAIV), was recently discovered from rodents in Anjozorobe-Angavo forest in Madagascar. To assess the circulation of hantavirus at the national level, we carried out a survey of small terrestrial mammals from representative regions of the island and identified environmental factors associated with hantavirus infection...
May 9, 2018: Virology Journal
https://www.readbyqxmd.com/read/29713899/global-diversity-and-distribution-of-hantaviruses-and-their-hosts
#8
REVIEW
Matthew T Milholland, Iván Castro-Arellano, Gerardo Suzán, Gabriel E Garcia-Peña, Thomas E Lee, Rodney E Rohde, A Alonso Aguirre, James N Mills
Rodents represent 42% of the world's mammalian biodiversity encompassing 2,277 species populating every continent (except Antarctica) and are reservoir hosts for a wide diversity of disease agents. Thus, knowing the identity, diversity, host-pathogen relationships, and geographic distribution of rodent-borne zoonotic pathogens, is essential for predicting and mitigating zoonotic disease outbreaks. Hantaviruses are hosted by numerous rodent reservoirs. However, the diversity of rodents harboring hantaviruses is likely unknown because research is biased toward specific reservoir hosts and viruses...
April 30, 2018: EcoHealth
https://www.readbyqxmd.com/read/29706488/corrigendum-to-phylogenetic-analysis-of-a-newfound-bat-borne-hantavirus-supports-a-laurasiatherian-host-association-for-ancestral-mammalian-hantaviruses-infect-genet-evol-41-2016-113-119
#9
Peter T Witkowski, Jan F Drexler, René Kallies, Martina Ličková, Silvia Bokorová, Gael D Maganga, Tomáš Szemes, Eric M Leroy, Detlev H Krüger, Christian Drosten, Boris Klempa
No abstract text is available yet for this article.
April 26, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29666240/urbanization-prolongs-hantavirus-epidemics-in-cities
#10
Huaiyu Tian, Shixiong Hu, Bernard Cazelles, Gerardo Chowell, Lidong Gao, Marko Laine, Yapin Li, Huisuo Yang, Yidan Li, Qiqi Yang, Xin Tong, Ru Huang, Ottar N Bjornstad, Hong Xiao, Nils Chr Stenseth
Urbanization and rural-urban migration are two factors driving global patterns of disease and mortality. There is significant concern about their potential impact on disease burden and the effectiveness of current control approaches. Few attempts have been made to increase our understanding of the relationship between urbanization and disease dynamics, although it is generally believed that urban living has contributed to reductions in communicable disease burden in industrialized countries. To investigate this relationship, we carried out spatiotemporal analyses using a 48-year-long dataset of hemorrhagic fever with renal syndrome incidence (HFRS; mainly caused by two serotypes of hantavirus in China: Hantaan virus and Seoul virus) and population movements in an important endemic area of south China during the period 1963-2010...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29649524/hantavirus-lectures-in-geography
#11
Dieter Stürchler
No abstract text is available yet for this article.
April 9, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29608398/a-high-throughput-flow-cytometry-screen-identifies-molecules-that-inhibit-hantavirus-cell-entry
#12
Tione Buranda, Catherine Gineste, Yang Wu, Virginie Bondu, Dominique Perez, Kaylin R Lake, Bruce S Edwards, Larry A Sklar
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which infects more than 200,000 people worldwide. Sin Nombre virus (SNV) and Andes virus (ANDV) cause the most severe form of HCPS, with case fatality ratios of 30%-40%. There are no specific therapies or vaccines for SNV. Using high-throughput flow cytometry, we screened the Prestwick Chemical Library for small-molecule inhibitors of the binding interaction between UV-inactivated and fluorescently labeled SNVR18 particles, and decay-accelerating factor (DAF) expressed on Tanoue B cells...
April 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29587642/guillain-barre-syndrome-associated-with-hemorrhagic-fever-with-renal-syndrome-in-china-a-case-report
#13
Jie Jiao, Lei Wu, Jianyuan Yin, Xiaojiao Quan, Wei Chen, Jie Hu
BACKGROUND: We describe a case of Guillain-Barre syndrome (GBS) associated with hemorrhagic fever with renal syndrome. To our knowledge, only five cases of GBS associated with Hantavirus infection have been reported so far. CASE PRESENTATIONS: A 62-year-old man presented intermittent fever, chill and oliguria. According to remarkable leukocytosis, atypical lymphocytes, thrombocytopenia and former dwelling in hemorrhagic fever-endemic area, he was suspected as hemorrhagic fever with renal syndromeand certified with positive Hantavirus IgG...
March 27, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29567745/complete-genome-sequences-of-a-hantavirus-isolate-from-new-york
#14
L K McMullan, C G Albariño, T G Ksiazek, S T Nichol, C F Spiropoulou
We report here the complete genome sequences for all three segments of the New York hantavirus (New York 1). This is the first reported L segment sequence for hantaviruses maintained in Peromyscus spp. endemic to the eastern United States and Canada.
March 22, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29563720/a-nonfatal-case-of-dobrava-hantavirus-hemorrhagic-fever-with-renal-syndrome-combined-with-hantavirus-cardiopulmonary-syndrome
#15
Shemsedin Dreshaj, Lindita Ajazaj, Nderim Hasani, Bahrije Halili, Albina Ponosheci, Xhevat Jakupi
Among hantaviruses (HTNV), 22 are known as pathogenic for humans. HTNV can cause two clinical entities: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome or hantavirus cardiopulmonary syndrome (HCPS). In most countries of Eastern Europe as well as in Kosovo, HTNV infection is presented mainly as HFRS. Here, we report a 20-year-old man with HFRS and HCPS caused by Dobrava hantavirus strain, successfully treated in Intensive Care Unit of Infectious Diseases Clinic, University Clinical Center of Kosovo...
January 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29488118/involvement-of-cd8-t-cells-in-the-development-of-renal-hemorrhage-in-a-mouse-model-of-hemorrhagic-fever-with-renal-syndrome
#16
Kenta Shimizu, Kumiko Yoshimatsu, Midori Taruishi, Yoshimi Tsuda, Jiro Arikawa
Hemorrhagic fever with renal syndrome (HFRS) is caused by hantavirus infection. Although host immunity is thought to be involved in the pathogenesis of HFRS, the mechanism remains to be elucidated. A mouse model of HFRS, which showed renal hemorrhage similar to that seen in patients, has been developed previously. In this study, we aimed to clarify whether CD4+ and CD8+ T cells are involved in the development of renal hemorrhage in the mouse model. At 2 days before virus inoculation, CD4+ or CD8+ T cells in 6-week-old BALB/c mice were depleted by administration of antibodies...
February 27, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29450213/differential-regulation-of-pai-1-in-hantavirus-cardiopulmonary-syndrome-and-hemorrhagic-fever-with-renal-syndrome
#17
Carla Bellomo, Miša Korva, Anna Papa, Satu Mäkelä, Jukka Mustonen, Tatjana Avšič-Županc, Antti Vaheri, Valeria P Martinez, Tomas Strandin
We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29446472/hantavirus-induced-cardiopulmonary-syndrome-a-public-health-concern
#18
REVIEW
Sibghat T Llah, Sheema Mir, Sumaiya Sharif, Salman Khan, Mohammed A Mir
Hantavirus cardiopulmonary syndrome is characterized by pulmonary capillary leakage and alveolar flooding, resulting in 50% mortality due to fulminant hypoxic respiratory failure. In addition, depression of cardiac function ensues, which complicates the picture with cardiogenic shock. Early diagnosis and appropriate use of extracorporeal membrane oxygenation (ECMO) are amongst the lifesaving interventions in this fatal illness. However, a recent case report demonstrates that implementation of high volume continuous hemofilteration along with protective ventilation reverses the cardiogenic shock within few hours in hantavirus infected patients...
June 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29437551/parallel-survey-of-two-widespread-renal-syndrome-causing-zoonoses-leptospira-spp-and-hantavirus-in-urban-environment-hungary
#19
Kornélia Kurucz, Mónika Madai, Dominika Bali, Dávid Hederics, Győző Horváth, Gábor Kemenesi, Ferenc Jakab
Rodents are important reservoir hosts for several zoonotic pathogens that cause significant morbidity and mortality in humans. Among others, leptospirosis is one of the most widespread zoonotic diseases worldwide and has the similar clinical manifestation with hantavirus infection in humans. Despite the fact that both pathogens have great epidemiological significance in Europe, no epizootiological data exist for urbanized areas so far. Therefore, this study was conducted to investigate the occurrence and prevalence of Leptospira spp...
April 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29428460/severe-hantavirus-disease-in-children
#20
Tamara K Dzagurova, Evgeniy A Tkachenko, Aydar A Ishmukhametov, Mariya V Balovneva, Boris Klempa, Detlev H Kruger
BACKGROUND: Very recently, a novel European hantavirus, Sochi virus, has been discovered which causes severe courses of hantavirus disease with a case fatality rate of about 15 percent. OBJECTIVES: We aimed to study to which extent and with which clinical severity children were affected by Sochi virus infection. STUDY DESIGN: Sochi virus infection of patients was confirmed by molecular, serological, and epizoonotic studies. Clinical and laboratory parameters were analyzed for the age group of up to 15 years (n = 6) in comparison to all older patients (n = 56)...
April 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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