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https://www.readbyqxmd.com/read/28518021/endemic-hantavirus-in-field-voles-northern-england
#1
Anna G Thomason, Michael Begon, Janette E Bradley, Steve Paterson, Joseph A Jackson
We report a PCR survey of hantavirus infection in an extensive field vole (Microtus agrestis) population present in the Kielder Forest, northern England. A Tatenale virus-like lineage was frequently detected (≈17% prevalence) in liver tissue. Lineages genetically similar to Tatenale virus are likely to be endemic in northern England.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28505175/structural-insights-into-reptarenavirus-cap-snatching-machinery
#2
Maria Rosenthal, Nadja Gogrefe, Dominik Vogel, Juan Reguera, Bianka Rauschenberger, Stephen Cusack, Stephan Günther, Sophia Reindl
Cap-snatching was first discovered in influenza virus. Structures of the involved domains of the influenza virus polymerase, namely the endonuclease in the PA subunit and the cap-binding domain in the PB2 subunit, have been solved. Cap-snatching endonucleases have also been demonstrated at the very N-terminus of the L proteins of mammarena-, orthobunya-, and hantaviruses. However, a cap-binding domain has not been identified in an arena- or bunyavirus L protein so far. We solved the structure of the 326 C-terminal residues of the L protein of California Academy of Sciences virus (CASV), a reptarenavirus, by X-ray crystallography...
May 15, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28504470/hemorrhagic-fever-with-renal-syndrome-caused-by-hantaan-virus-infection-in-4-pregnant-chinese-women
#3
Fanpu Ji, Wenxuan Zhao, Hailing Liu, Hongbo Zheng, Shengbang Wang, Caini He, Wenjun Wang, Ruijuan Zhang, Dan Bai, Changyin Tian, Wenxue Zhao, Hong Deng
Hantavirus infection during pregnancy can influence both maternal and fetal outcomes. Here, we describe four cases of hemorrhagic fever with renal syndrome (HFRS) in pregnant Chinese women. The HFRS put these women at increased risk for severe illness, despite the patients' symptomologies in the onset phase were similar to those observed in non-pregnant HFRS patients, such as fever, headache, nausea and thrombocytopenia. Pregnant women appeared to have a more severe status, presenting with severe complications, such as hypervolemia and pulmonary edema...
May 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28468076/-recombinant-expression-of-hantaan-virus-protein-n-with-application-of-western-blot-in-detecting-anti-hantavirus-antibody
#4
P P Yao, F Xu, Y S Sun, Z R Yang, Y Zhang, M Yue, H P Zhu
Objective: S gene of hantavirus(HV) was expressed in insect cells by genetic engineering technology. The expression product of S gene was used as antigen to detect anti-HV specific antibody IgG in serum. Methods: Gene encoding NP of the strain HV-Z10 was amplified by PCR and then its eukaryotic expression system rBAC-Z10S-TN was constructed by using the routine genetic engineering method. SDS-PAGE was applied to measure the expression of rNP.Ion-exchange plus Ni-NTA-affinity chromatography was performed to purify the recombinant product...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28463210/hantavirus-pulmonary-syndrome-in-tucum%C3%A3-n-province-associated-to-an-unexpected-viral-genotype
#5
Matías Ciancaglini, Carla M Bellomo, Clara L Torres Cabreros, Daniel Alonso, Sabrina C Bassi, Ayelén A Iglesias, Valeria P Martínez
We describe the characterization of the viral genotype involved in the first case of hantavirus pulmonary syndrome reported in Tucumán, a Northwestern province of Argentina. A 23-year-old woman, with no record of travel history and previously diagnosed with an antiphospholipid syndrome, died after 11 days of severe cardiopulmonary insufficiency. Among the four endemic regions of hantavirus pulmonary syndrome in Argentina, the Northwest Region has the highest incidence, exceeding 50% of all reported cases in the country...
2017: Medicina
https://www.readbyqxmd.com/read/28448595/hantavirus-surveillance-and-genetic-diversity-targeting-small-mammals-at-camp-humphreys-a-us-military-installation-and-new-expansion-site-republic-of-korea
#6
Heung-Chul Kim, Won-Keun Kim, Terry A Klein, Sung-Tae Chong, Peter V Nunn, Jeong-Ah Kim, Seung-Ho Lee, Jin Sun No, Jin-Won Song
Small mammal surveillance was conducted (2008-2010, 2012) at Camp (Cp) Humphreys, a US Army installation and new expansion site, Republic of Korea (ROK), to identify hemorrhagic fever with renal syndrome health threats to US military/civilian populations during its ongoing expansion phase. Small mammals were collected using Sherman live capture traps and transported to Korea University where they were euthanized, tissues removed, and assayed to determine hantavirus IgG antibody-positive and hantavirus-positive rates by RT-PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28447136/-environmental-health-relevance-of-airborne-microorganisms-in-ambient-and-indoor-air
#7
REVIEW
Sandra M Walser, Bernhard Brenner, Stefanie Heinze, Regine Szewzyk, Eike Wolter, Caroline E W Herr
Airborne microorganisms occur ubiquitously in the ambient air. Besides allergic and irritative-toxic effects, they can cause infections after inhalation. Occupational studies have shown that an increased incidence of respiratory diseases is found in adequately exposed workers. In addition to respiratory diseases, severe systemic infections can also occur in particular cases, such as in the case of a hantavirus infection that is recognized as an occupational disease. In studies from environmental medicine, respiratory diseases have also been observed in residents living in the vicinity of livestock facilities and evaporative cooling towers...
April 26, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28433053/the-envelope-proteins-of-the-bunyavirales
#8
Pablo Guardado-Calvo, Félix A Rey
The Bunyavirales Order encompasses nine families of enveloped viruses containing a single-stranded negative-sense RNA genome divided into three segments. The small (S) and large (L) segments encode proteins participating in genome replication in the infected cell cytoplasm. The middle (M) segment encodes the viral glycoproteins Gn and Gc, which are derived from a precursor polyprotein by host cell proteases. Entry studies are available only for a few viruses in the Order, and in each case they were shown to enter cells via receptor-mediated endocytosis...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28418734/bunyaviridae-rdrps-structure-motifs-and-rna-synthesis-machinery
#9
Abdennour Amroun, Stéphane Priet, Xavier de Lamballerie, Gilles Quérat
Bunyaviridae family is the largest and most diverse family of RNA viruses. It has more than 350 members divided into five genera: Orthobunyavirus, Phlebovirus, Nairovirus, Hantavirus, and Tospovirus. They are present in the five continents, causing recurrent epidemics, epizootics, and considerable agricultural loss. The genome of bunyaviruses is divided into three segments of negative single-stranded RNA according to their relative size: L (Large), M (Medium) and S (Small) segment. Bunyaviridae RNA-dependent RNA polymerase (RdRp) is encoded by the L segment, and is in charge of the replication and transcription of the viral RNA in the cytoplasm of the infected cell...
April 18, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28418312/exposure-characteristics-of-hantavirus-pulmonary-syndrome-patients-united-states-1993-2015
#10
Annabelle de St Maurice, Elizabeth Ervin, Mare Schumacher, Hayley Yaglom, Elizabeth VinHatton, Sandra Melman, Ken Komatsu, Jennifer House, Dallin Peterson, Danielle Buttke, Alison Ryan, Del Yazzie, Craig Manning, Paul Ettestad, Pierre Rollin, Barbara Knust
Those at highest risk are persons in occupations with potential for rodent exposure and American Indian women 40--64 years of age.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28411480/hemorrhagic-fever-with-renal-syndrome-in-albania-focus-on-predictors-of-acute-kidney-injury-in-hfrs
#11
Elvana Rista, Arben Pilaca, Ilir Akshija, Ariol Rama, Endri Harja, Edmond Puca, Silvia Bino, Vilma Cadri, Majlinda Kota, Thereska Nestor, Harxhi Arjan
BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is a rodent borne zoonosis, caused by the members of the family Bunyaviridae, genus Hantavirus. The main clinical features of the infection by this virus family are fever, thrombocytopenia and acute kidney injury. OBJECTIVE: The aim of our study was to identify, for the first time, characteristic features of HFRS in the Albanian population. STUDY DESIGN: The study comprised 33 consecutive patients admitted with suspected HFRS from April 2011-April 2016 at one center...
March 31, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28399204/detection-of-a-novel-rickettsia-from-leptotrombidium-scutellare-mites-acari-trombiculidae-from-shandong-of-china
#12
Yuting Huang, Li Zhao, Zhentang Zhang, Miaomiao Liu, Zaifeng Xue, Dongqiang Ma, Xifeng Sun, Yue Sun, Chuanmin Zhou, Xiangrong Qin, Yelei Zhu, Wenqian Li, Hao Yu, Xue-Jie Yu
Leptotrombidium scutellare mites, the vector of Orientia tsutsugamushi, have rarely been reported to associate with Rickettsia species. Three hundred nineteen chiggers were collected from the ears of 32 rodents captured in Huangdao District of Qingdao City, China, in October 2015. The chigger samples were tested for Rickettsia, severe fever with thrombocytopenia syndrome virus, and hantavirus by PCR or RT-PCR amplification. All mites were classified morphologically and molecularly as L. scutellare chiggers...
May 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28371451/novel-coronaviruses-astroviruses-adenoviruses-and-circoviruses-in-insectivorous-bats-from-northern-china
#13
H-J Han, H-L Wen, L Zhao, J-W Liu, L-M Luo, C-M Zhou, X-R Qin, Y-L Zhu, M-M Liu, R Qi, W-Q Li, H Yu, X-J Yu
Bats are considered as the reservoirs of several emerging infectious disease, and novel viruses are continually found in bats all around the world. Studies conducted in southern China found that bats carried a variety of viruses. However, few studies have been conducted on bats in northern China, which harbours a diversity of endemic insectivorous bats. It is important to understand the prevalence and diversity of viruses circulating in bats in northern China. In this study, a total of 145 insectivorous bats representing six species were collected from northern China and screened with degenerate primers for viruses belonging to six families, including coronaviruses, astroviruses, hantaviruses, paramyxoviruses, adenoviruses and circoviruses...
April 1, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28368241/seoul-virus-infection-in-humans-france-2014-2016
#14
Jean-Marc Reynes, Damien Carli, Jean-Baptiste Bour, Samir Boudjeltia, Anny Dewilde, Guillaume Gerbier, Timothée Nussbaumer, Véronique Jacomo, Marie-Pierre Rapt, Pierre E Rollin, Alexandra Septfons
We report detection of Seoul virus in 3 patients in France over a 2-year period. These patients accounted for 4 (1.7%) of 434 hantavirus infections reported during this time. More attention should be given to this virus in Europe where surveillance has been focused mostly on Puumala and Dobrava-Belgrade hantaviruses.
June 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28340538/development-of-high-throughput-screening-assay-for-antihantaviral-therapeutics
#15
Anuradha Roy, Mohammad A Mir
Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. There is no treatment for hantavirus diseases at present. Therapeutic intervention during early stages of viral infection can improve the outcome of this zoonotic viral illness. The interaction between an evolutionary conserved sequence at the 5' terminus of hantaviral genomic RNA and hantavirus nucleocapsid protein plays a critical role in the hantavirus replication cycle. This unique interaction is a novel target for therapeutic intervention of hantavirus disease...
March 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28332927/leptospira-spp-in-small-mammals-from-areas-with-low-and-high-human-hantavirus-incidences-in-south-west-germany
#16
Anna Obiegala, Christoph Albrecht, Maysaa Dafalla, Stephan Drewes, Carolin Oltersdorf, Hendrik Turni, Christian Imholt, Jens Jacob, Christiane Wagner-Wiening, Rainer G Ulrich, Martin Pfeffer
INTRODUCTION: Leptospirosis is caused by Leptospira spp. and is considered the most widespread zoonotic disease worldwide. It mimics nephropathia epidemica in humans, a disease mainly caused by Puumala hantavirus (PUUV). Small mammals are reservoirs for Leptospira spp. and PUUV. Seewis virus (SWSV) is a shrew-borne hantavirus with unknown pathogenicity. The objective of this study was to estimate the prevalence for Leptospira spp. and the frequency of Leptospira-hantavirus co-infections in small mammals collected at locations with high and low incidences in humans...
May 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28319945/glomerular-proteinuria-predicts-the-severity-of-acute-kidney-injury-in-puumala-hantavirus-induced-tubulointerstitial-nephritis
#17
Paula S Mantula, Tuula K Outinen, Jan P G Clement, Heini S A Huhtala, Ilkka H Pörsti, Antti Vaheri, Jukka T Mustonen, Satu M Mäkelä
BACKGROUND: Puumala virus (PUUV)-induced hemorrhagic fever with renal syndrome is common in many European countries. The typical renal histologic lesion is acute tubulointerstitial nephritis. We examined the type and kinetics of urine protein excretion and prognostic significance of proteinuria for the severity of acute kidney injury (AKI) in acute PUUV infection. METHODS: The amount of dipstick albuminuria at hospital admission was analyzed in 205 patients with acute PUUV infection...
March 21, 2017: Nephron
https://www.readbyqxmd.com/read/28315705/estimation-of-main-diversification-time-points-of-hantaviruses-using-phylogenetic-analyses-of-complete-genomes
#18
Guillaume Castel, Noël Tordo, Alexander Plyusnin
Because of the great variability of their reservoir hosts, hantaviruses are excellent models to evaluate the dynamics of virus-host co-evolution. Intriguing questions remain about the timescale of the diversification events that influenced this evolution. In this paper we attempted to estimate the first ever timing of hantavirus diversification based on thirty five available complete genomes representing five major groups of hantaviruses and the assumption of co-speciation of hantaviruses with their respective mammal hosts...
March 16, 2017: Virus Research
https://www.readbyqxmd.com/read/28295052/dynamic-circulation-and-genetic-exchange-of-a-shrew-borne-hantavirus-imjin-virus-in-the-republic-of-korea
#19
Seung-Ho Lee, Won-Keun Kim, Jin Sun No, Jeong-Ah Kim, Jin Il Kim, Se Hun Gu, Heung-Chul Kim, Terry A Klein, Man-Seong Park, Jin-Won Song
Hantaviruses (family Bunyaviridae) are enveloped negative-sense tripartite RNA viruses. The natural hosts of hantaviruses include rodents, shrews, moles, and bats. Imjin virus (MJNV) is a shrew-borne hantavirus identified from the Ussuri white-toothed shrews (Crocidura lasiura) in the Republic of Korea (ROK) and China. We have isolated MJNV and determined its prevalence and molecular diversity in Gyeonggi province, ROK. However, the distribution and phylogeography of MJNV in other regions of ROK remain unknown...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28287930/detection-of-imjin-virus-and-seoul-virus-in-crocidurine-shrews-in-shandong-province-china
#20
Xi-Feng Sun, Li Zhao, Zhen-Tang Zhang, Miao-Miao Liu, Zai-Feng Xue, Hong-Ling Wen, Dong-Qiang Ma, Yu-Ting Huang, Yue Sun, Chuan-Min Zhou, Li-Mei Luo, Jian-Wei Liu, Wen-Qian Li, Hao Yu, Xue-Jie Yu
INTRODUCTION: Recently, hantaviruses have been discovered in insectivores in Europe, Asia, Africa, and North America. Imjin virus (MJNV) was first isolated from the lung tissues of Ussuri white-toothed shrew (Crocidura lasiura) from South Korea in 2009. We aim to detect the species and prevalence of insectivore- and rodent-borne hantaviruses in shrews and rodents. MATERIALS AND METHODS: Shrews and rodents were captured in Jiaonan County of Shandong Province, China, in 2014...
March 13, 2017: Vector Borne and Zoonotic Diseases
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