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https://www.readbyqxmd.com/read/28433053/the-envelope-proteins-of-the-bunyavirales
#1
Pablo Guardado-Calvo, Félix A Rey
The Bunyavirales Order encompasses nine families of enveloped viruses containing a single-stranded negative-sense RNA genome divided into three segments. The small (S) and large (L) segments encode proteins participating in genome replication in the infected cell cytoplasm. The middle (M) segment encodes the viral glycoproteins Gn and Gc, which are derived from a precursor polyprotein by host cell proteases. Entry studies are available only for a few viruses in the Order, and in each case they were shown to enter cells via receptor-mediated endocytosis...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28418734/bunyaviridae-rdrps-structure-motifs-and-rna-synthesis-machinery
#2
Abdennour Amroun, Stéphane Priet, Xavier de Lamballerie, Gilles Quérat
Bunyaviridae family is the largest and most diverse family of RNA viruses. It has more than 350 members divided into five genera: Orthobunyavirus, Phlebovirus, Nairovirus, Hantavirus, and Tospovirus. They are present in the five continents, causing recurrent epidemics, epizootics, and considerable agricultural loss. The genome of bunyaviruses is divided into three segments of negative single-stranded RNA according to their relative size: L (Large), M (Medium) and S (Small) segment. Bunyaviridae RNA-dependent RNA polymerase (RdRp) is encoded by the L segment, and is in charge of the replication and transcription of the viral RNA in the cytoplasm of the infected cell...
April 18, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28418312/exposure-characteristics-of-hantavirus-pulmonary-syndrome-patients-united-states-1993-2015
#3
Annabelle de St Maurice, Elizabeth Ervin, Mare Schumacher, Hayley Yaglom, Elizabeth VinHatton, Sandra Melman, Ken Komatsu, Jennifer House, Dallin Peterson, Danielle Buttke, Alison Ryan, Del Yazzie, Craig Manning, Paul Ettestad, Pierre Rollin, Barbara Knust
Those at highest risk are persons in occupations with potential for rodent exposure and American Indian women 40--64 years of age.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28411480/hemorrhagic-fever-with-renal-syndrome-in-albania-focus-on-predictors-of-acute-kidney-injury-in-hfrs
#4
Elvana Rista, Arben Pilaca, Ilir Akshija, Ariol Rama, Endri Harja, Edmond Puca, Silvia Bino, Vilma Cadri, Majlinda Kota, Thereska Nestor, Harxhi Arjan
BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is a rodent borne zoonosis, caused by the members of the family Bunyaviridae, genus Hantavirus. The main clinical features of the infection by this virus family are fever, thrombocytopenia and acute kidney injury. OBJECTIVE: The aim of our study was to identify, for the first time, characteristic features of HFRS in the Albanian population. STUDY DESIGN: The study comprised 33 consecutive patients admitted with suspected HFRS from April 2011-April 2016 at one center...
March 31, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28399204/detection-of-a-novel-rickettsia-from-leptotrombidium-scutellare-mites-acari-trombiculidae-from-shandong-of-china
#5
Yuting Huang, Li Zhao, Zhentang Zhang, Miaomiao Liu, Zaifeng Xue, Dongqiang Ma, Xifeng Sun, Yue Sun, Chuanmin Zhou, Xiangrong Qin, Yelei Zhu, Wenqian Li, Hao Yu, Xue-Jie Yu
Leptotrombidium scutellare mites, the vector of Orientia tsutsugamushi, have rarely been reported to associate with Rickettsia species. Three hundred nineteen chiggers were collected from the ears of 32 rodents captured in Huangdao District of Qingdao City, China, in October 2015. The chigger samples were tested for Rickettsia, severe fever with thrombocytopenia syndrome virus, and hantavirus by PCR or RT-PCR amplification. All mites were classified morphologically and molecularly as L. scutellare chiggers...
February 17, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28371451/novel-coronaviruses-astroviruses-adenoviruses-and-circoviruses-in-insectivorous-bats-from-northern-china
#6
H-J Han, H-L Wen, L Zhao, J-W Liu, L-M Luo, C-M Zhou, X-R Qin, Y-L Zhu, M-M Liu, R Qi, W-Q Li, H Yu, X-J Yu
Bats are considered as the reservoirs of several emerging infectious disease, and novel viruses are continually found in bats all around the world. Studies conducted in southern China found that bats carried a variety of viruses. However, few studies have been conducted on bats in northern China, which harbours a diversity of endemic insectivorous bats. It is important to understand the prevalence and diversity of viruses circulating in bats in northern China. In this study, a total of 145 insectivorous bats representing six species were collected from northern China and screened with degenerate primers for viruses belonging to six families, including coronaviruses, astroviruses, hantaviruses, paramyxoviruses, adenoviruses and circoviruses...
April 1, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28368241/seoul-virus-infection-in-humans-france-2014-2016
#7
Jean-Marc Reynes, Damien Carli, Jean-Baptiste Bour, Samir Boudjeltia, Anny Dewilde, Guillaume Gerbier, Timothée Nussbaumer, Véronique Jacomo, Marie-Pierre Rapt, Pierre E Rollin, Alexandra Septfons
We report detection of Seoul virus in 3 patients in France over a 2-year period. These patients accounted for 4 (1.7%) of 434 hantavirus infections reported during this time. More attention should be given to this virus in Europe where surveillance has been focused mostly on Puumala and Dobrava-Belgrade hantaviruses.
June 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28340538/development-of-high-throughput-screening-assay-for-antihantaviral-therapeutics
#8
Anuradha Roy, Mohammad A Mir
Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. There is no treatment for hantavirus diseases at present. Therapeutic intervention during early stages of viral infection can improve the outcome of this zoonotic viral illness. The interaction between an evolutionary conserved sequence at the 5' terminus of hantaviral genomic RNA and hantavirus nucleocapsid protein plays a critical role in the hantavirus replication cycle. This unique interaction is a novel target for therapeutic intervention of hantavirus disease...
March 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28332927/leptospira-spp-in-small-mammals-from-areas-with-low-and-high-human-hantavirus-incidences-in-south-west-germany
#9
Anna Obiegala, Christoph Albrecht, Maysaa Dafalla, Stephan Drewes, Carolin Oltersdorf, Hendrik Turni, Christian Imholt, Jens Jacob, Christiane Wagner-Wiening, Rainer G Ulrich, Martin Pfeffer
INTRODUCTION: Leptospirosis is caused by Leptospira spp. and is considered the most widespread zoonotic disease worldwide. It mimics nephropathia epidemica in humans, a disease mainly caused by Puumala hantavirus (PUUV). Small mammals are reservoirs for Leptospira spp. and PUUV. Seewis virus (SWSV) is a shrew-borne hantavirus with unknown pathogenicity. The objective of this study was to estimate the prevalence for Leptospira spp. and the frequency of Leptospira-hantavirus co-infections in small mammals collected at locations with high and low incidences in humans...
March 23, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28319945/glomerular-proteinuria-predicts-the-severity-of-acute-kidney-injury-in-puumala-hantavirus-induced-tubulointerstitial-nephritis
#10
Paula S Mantula, Tuula K Outinen, Jan P G Clement, Heini S A Huhtala, Ilkka H Pörsti, Antti Vaheri, Jukka T Mustonen, Satu M Mäkelä
BACKGROUND: Puumala virus (PUUV)-induced hemorrhagic fever with renal syndrome is common in many European countries. The typical renal histologic lesion is acute tubulointerstitial nephritis. We examined the type and kinetics of urine protein excretion and prognostic significance of proteinuria for the severity of acute kidney injury (AKI) in acute PUUV infection. METHODS: The amount of dipstick albuminuria at hospital admission was analyzed in 205 patients with acute PUUV infection...
March 21, 2017: Nephron
https://www.readbyqxmd.com/read/28315705/estimation-of-main-diversification-time-points-of-hantaviruses-using-phylogenetic-analyses-of-complete-genomes
#11
Guillaume Castel, Noël Tordo, Alexander Plyusnin
Because of the great variability of their reservoir hosts, hantaviruses are excellent models to evaluate the dynamics of virus-host co-evolution. Intriguing questions remain about the timescale of the diversification events that influenced this evolution. In this paper we attempted to estimate the first ever timing of hantavirus diversification based on thirty five available complete genomes representing five major groups of hantaviruses and the assumption of co-speciation of hantaviruses with their respective mammal hosts...
March 16, 2017: Virus Research
https://www.readbyqxmd.com/read/28295052/dynamic-circulation-and-genetic-exchange-of-a-shrew-borne-hantavirus-imjin-virus-in-the-republic-of-korea
#12
Seung-Ho Lee, Won-Keun Kim, Jin Sun No, Jeong-Ah Kim, Jin Il Kim, Se Hun Gu, Heung-Chul Kim, Terry A Klein, Man-Seong Park, Jin-Won Song
Hantaviruses (family Bunyaviridae) are enveloped negative-sense tripartite RNA viruses. The natural hosts of hantaviruses include rodents, shrews, moles, and bats. Imjin virus (MJNV) is a shrew-borne hantavirus identified from the Ussuri white-toothed shrews (Crocidura lasiura) in the Republic of Korea (ROK) and China. We have isolated MJNV and determined its prevalence and molecular diversity in Gyeonggi province, ROK. However, the distribution and phylogeography of MJNV in other regions of ROK remain unknown...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28287930/detection-of-imjin-virus-and-seoul-virus-in-crocidurine-shrews-in-shandong-province-china
#13
Xi-Feng Sun, Li Zhao, Zhen-Tang Zhang, Miao-Miao Liu, Zai-Feng Xue, Hong-Ling Wen, Dong-Qiang Ma, Yu-Ting Huang, Yue Sun, Chuan-Min Zhou, Li-Mei Luo, Jian-Wei Liu, Wen-Qian Li, Hao Yu, Xue-Jie Yu
INTRODUCTION: Recently, hantaviruses have been discovered in insectivores in Europe, Asia, Africa, and North America. Imjin virus (MJNV) was first isolated from the lung tissues of Ussuri white-toothed shrew (Crocidura lasiura) from South Korea in 2009. We aim to detect the species and prevalence of insectivore- and rodent-borne hantaviruses in shrews and rodents. MATERIALS AND METHODS: Shrews and rodents were captured in Jiaonan County of Shandong Province, China, in 2014...
March 13, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28249631/expansion-of-spatial-and-host-range-of-puumala-virus-in-sweden-an-increasing-threat-for-humans
#14
O Borg, M Wille, P Kjellander, U A Bergvall, P-E Lindgren, J Chirico, Å Lundkvist
Hantaviruses are globally distributed and cause severe human disease. Puumala hantavirus (PUUV) is the most common species in Northern Europe, and the only hantavirus confirmed to circulate in Sweden, restricted to the northern regions of the country. In this study, we aimed to further add to the natural ecology of PUUV in Sweden by investigating prevalence, and spatial and host species infection patterns. Specifically, we wanted to ascertain whether PUUV was present in the natural reservoir, the bank vole (Myodes glareolus) further south than Dalälven river, in south-central Sweden, and whether PUUV can be detected in other rodent species in addition to the natural reservoir...
March 2, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28245831/puumala-hantavirus-infections-in-bank-vole-populations-host-and-virus-dynamics-in-central-europe
#15
Daniela Reil, Ulrike M Rosenfeld, Christian Imholt, Sabrina Schmidt, Rainer G Ulrich, Jana A Eccard, Jens Jacob
BACKGROUND: In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010-2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies...
February 28, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28237172/hantavirus-retinitis-and-concurrent-hemorrhagic-fever-with-renal-syndrome
#16
Yanna Cao, Xingping Zhao, Junhui Yi, Renhong Tang, Shaobo Lei
No abstract text is available yet for this article.
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28229289/clinical-aspects-of-hantavirus-infections-in-bulgaria
#17
I Christova, M Pishmisheva, I Trifonova, N Vatev, M Stoycheva, M Tiholova, D Igova, M Baev, R Karagyaurova, U Prokopova
BACKGROUND: Hantaviruses cause two distinct human diseases: hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe and hantavirus pulmonary syndrome (HPS) in America. In Europe, mainly Puumala, Dobrava and Seoul viruses cause HFRS. A total of 23 cases of HFRS were detected in Bulgaria over a 2‑year period 2013-2014. The aim of the study was to present epidemiology, clinical manifestations and laboratory findings of these patients. METHODS: Patients with HFRS were diagnosed using PCR, ELISA and immunoblotting tests...
February 22, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28228923/rodent-species-distribution-and-hantavirus-seroprevalence-in-residential-and-forested-areas-of-sarawak-malaysia
#18
Nur Elfieyra Syazana Hamdan, Yee Ling Ng, Wei Bin Lee, Cheng Siang Tan, Faisal Ali Anwarali Khan, Yee Ling Chong
Rodents belong to the order Rodentia, which consists of three families in Borneo (i.e., Muridae, Sciuridae and Hystricidae). These include rats, mice, squirrels, and porcupines. They are widespread throughout the world and considered pests that harm humans and livestock. Some rodent species are natural reservoirs of hantaviruses (Family: Bunyaviridae) that can cause zoonotic diseases in humans. Although hantavirus seropositive human sera were reported in Peninsular Malaysia in the early 1980s, information on their infection in rodent species in Malaysia is still lacking...
January 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28217934/population-dynamics-of-wild-rodents-induce-stochastic-fadeouts-of-a-zoonotic-pathogen
#19
Giorgio Guzzetta, Valentina Tagliapietra, Sarah E Perkins, Heidi C Hauffe, Piero Poletti, Stefano Merler, Annapaola Rizzoli
Stochastic processes play an important role in the infectious disease dynamics of wildlife, especially in species subject to large population oscillations. Here, we study the case of a free ranging population of yellow-necked mice (Apodemus flavicollis) in northern Italy, where circulation of Dobrava-Belgrade hantavirus (DOBV) has been detected intermittently since 2001, until an outbreak emerged in 2010. We analysed the transmission dynamics of the recent outbreak using a computational model that accounts for seasonal changes of the host population and territorial behaviour...
February 19, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28202761/the-long-noncoding-rna-neat1-exerts-anti-hantaviral-effects-by-acting-as-a-positive-feedback-for-rig-i-signaling
#20
Hongwei Ma, Peijun Han, Wei Ye, Hesong Chen, Xuyang Zheng, Linfeng Cheng, Liang Zhang, Lan Yu, Xing'an Wu, Zhikai Xu, Yingfeng Lei, Fanglin Zhang
Hantavirus infection, which causes zoonotic diseases with a high mortality rate in humans, has long been a global public health concern. Over the past decades, accumulating evidence suggests that long noncoding RNAs (lncRNAs) play key regulatory roles in innate immunity. However, the involvement of host lncRNAs in hantaviral control remains uncharacterized. In this study, we identified the lncRNA, NEAT1, as a vital antiviral modulator. NEAT1 was dramatically upregulated after Hantaan virus (HTNV) infection, whereas its downregulation in vitro or in vivo delayed host innate immune responses and aggravated HTNV replication...
February 15, 2017: Journal of Virology
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