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https://www.readbyqxmd.com/read/29334543/seminoma-metastatic-to-the-orbit
#1
Jonathan J Dutton, Alan D Proia
PURPOSE: Seminomas are solid tumors in young men, but which rarely metastasize to the orbit. The authors review the known literature on seminoma metastatic to the orbit, and describe an additional case in a 33-year-old man. METHODS: A literature search was performed on the MEDLINE database using keywords "seminoma," "testicular germ-cell tumors," "testicular cancer," "testicular neoplasm," "orbital metastasis," and "germ-cell neoplasms." RESULTS: Malignant neoplasms of the testis account for only 1% of cancers in men...
January 12, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29333356/metachronous-testicular-cancer-after-orchiectomy-a-rare-case
#2
Ersan Arda, Basri Cakiroglu, Gizem Cetin, Ilkan Yuksel
Testicular cancer represents approximately 1% of all cancers diagnosed in males. The prevalence of bilateral testicular germ cell tumor cases varies from 1% to 5%. Intratubular germ cell neoplasia (ITGCN) is a precursor for almost all testicular germ cell tumors (TGCT) and is one of the highest risks of developing contralateral testicular cancer. The radical orchiectomy is still preferred for the treatment of testicular cancer. However, in some cases like solitary testis, bilateral cancer or if the tumor size is under 30% percent of the testicular extent, organ-sparing surgery can be an option...
November 9, 2017: Curēus
https://www.readbyqxmd.com/read/29329231/development-of-a-cytocompatible-scaffold-from-pig-immature-testicular-tissue-allowing-human-sertoli-cell-attachment-proliferation-and-functionality
#3
Maxime Vermeulen, Federico Del Vento, Francesca de Michele, Jonathan Poels, Christine Wyns
Cryopreservation of immature testicular tissue before chemo/radiotherapy is the only option to preserve fertility of cancer-affected prepubertal boys. To avoid reintroduction of malignant cells, development of a transplantable scaffold by decellularization of pig immature testicular tissue (ITT) able to support decontaminated testicular cells could be an option for fertility restoration in these patients. We, therefore, compared decellularization protocols to produce a cytocompatible scaffold. Fragments of ITT from 15 piglets were decellularized using three protocols: sodium dodecyl sulfate (SDS)-Triton (ST), Triton-SDS-Triton (TST) and trypsin 0...
January 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29325693/updates-in-the-eighth-edition-of-the-tumor-node-metastasis-staging-classification-for-urologic-cancers
#4
REVIEW
Gladell P Paner, Walter M Stadler, Donna E Hansel, Rodolfo Montironi, Daniel W Lin, Mahul B Amin
The Tumor-Node-Metastasis (TNM) classification on cancer staging, jointly developed by the American Joint Commission on Cancer (AJCC) and the Union for International Cancer Control (UICC), has been updated to its 8th edition with two contemporaneous versions published by the AJCC and UICC. While the goal of the AJCC and UICC is to have identical TNM staging systems, differences exist between these two publications including in the staging of urologic cancers. Among several new facets in the AJCC staging manual, a select few of greater import include an expanded section on imaging, presentation of levels of evidence for significant changes, and endorsement of risk assessment models that pass the AJCC quality criteria such as in prostate cancer...
January 8, 2018: European Urology
https://www.readbyqxmd.com/read/29325584/adenomatoid-tumor-of-the-testis-mimicking-malignant-testicular-cancer-on-multiparametric-ultrasound
#5
Renate Pichler, Gennadi Tulchiner, Fabian Steinkohl, Afschin Soleiman, Wolfgang Horninger, Isabel Maria Heidegger, Friedrich Aigner
BACKGROUND: Adenomatoid tumor is one of the most common histological subtypes of paratesticular cancer arising from the epididymis. In very rare cases, these tumors appear as intratesticular lesions originating in the tunica albuginea, representing a diagnostic challenge. CASE PRESENTATION: We present a case of a 51-year-old man with a small (0.9 cm) hyperechoic lesion of the left testicle mimicking testicular cancer on multiparametric ultrasound. The lesion was localized in the peripheral zone, confirming vascularization and increased stiffness on contrast-enhanced ultrasound and real-time elastography...
January 11, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29310185/re-multi-institutional-assessment-of-adverse-health-outcomes-among-north-american-testicular-cancer-survivors-after-modern-cisplatin-based-chemotherapy
#6
https://www.readbyqxmd.com/read/29309804/experimental-models-of-testicular-development-and-function-using-human-tissue-and-cells
#7
REVIEW
Melissa Tharmalingam, Anne Jorgensen, Rod T Mitchell
The mammalian testis has two main roles, production of gametes for reproduction and synthesis of steroid- and peptide hormones for masculinization. These processes are tightly regulated and involve complex interactions between a number of germ and somatic cell-types that comprise a unique microenvironment known as the germ stem cell niche. In humans, failure of normal testicular development or function is associated with susceptibility to a variety of male reproductive disorders including disorders of sex development, infertility and testicular cancer...
January 5, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29309588/transmembrane-bax-inhibitor-motif-6-tmbim6-protects-against-cisplatin-induced-testicular-toxicity
#8
Hyun-Kyoung Kim, Raj Kumar Yadav, Kashi Raj Bhattarai, Han-Wool Jung, Hyung-Ryong Kim, Han-Jung Chae
STUDY QUESTION: Is the Transmembrane BAX Inhibitor Motif-6 (TMBIM6) involved in the molecular mechanism by which cisplatin causes reproductive toxicity? SUMMARY ANSWER: TMBIM6 protects against cisplatin-induced testicular toxicity through up-regulation of heme oxygenase-1 (HO-1),-which maintains the levels of steroidogenic enzymes by decreaseing oxidative stress in the endoplasmic reticulum (ER). WHAT IS KNOWN ALREADY: Testosterone production is highly suppressed as a main complication of cisplatin (cis-diamminedichloroplatinum) anticancer therapy...
January 4, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29309304/the-significance-of-spermatic-cord-involvement-by-testicular-germ-cell-tumors-should-we-be-staging-discontinuous-invasion-from-involved-lymphovascular-spaces-differently-from-direct-extension
#9
Joseph M Sanfrancesco, Karen E Trevino, Huiping Xu, Thomas M Ulbright, Muhammad T Idrees
The recent 8th edition of the American Joint Committee on Cancer (AJCC) staging manual had multiple changes concerning how pathologists should stage germ cell tumors (GCTs) of the testis. A significant one concerns the impact of different types of spermatic cord involvement, specifically direct tumor extension versus discontinuous involvement by invasion through lymphovascular spaces. We compared clinicopathologic findings and outcome data between 2 cohorts with these findings to evaluate the validity of the change in the AJCC 8th edition manual...
January 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29307603/an-x-linked-agammaglobulinemia-contiguous-gene-syndrome-with-metachronous-coprimary-testicular-cancers
#10
Marcus Shaker, Ting-Jia Lorigiano, Alexandra Lucas, Sergey Devitskiy, Youdinghuan Chen, Brock Christensen
No abstract text is available yet for this article.
January 4, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29307404/male-infertility-a-biomarker-of-individual-and-familial-cancer-risk
#11
REVIEW
Brent M Hanson, Michael L Eisenberg, James M Hotaling
Associations between male infertility and cancer are gaining clinical attention. Relationships between infertility and cancer have traditionally been studied in women, but recent work has focused on the male component of reproduction. Infertile men are at an elevated risk to develop various malignancies later in life, primarily genitourinary malignancies such as testicular and prostate cancer. Rates of testicular and high-grade prostate cancer in infertile men appear to be at least double the risk in the general population...
January 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29301513/testicular-self-examination-among-bahir-dar-university-students-application-of-integrated-behavioral-model
#12
Hordofa Gutema, Yamrot Debela, Bizuayehu Walle, Kidist Reba, Habtamu Wondiye
BACKGROUND: Though the incidence of Testicular cancer among young is rising, little attention is given to promoting testicular self-examination which is recommended for its early prevention in developing countries. This study aimed to assess testicular self-examination and associated factors among Bahir Dar University students using integrated behavioral model. METHODS: Cross sectional study was conducted among Bahir Dar University students in September, 2016. Systematic sampling technique was used to select 884 participants...
January 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29295694/molecular-mechanisms-of-resistance-in-testicular-germ-cell-tumors-clinical-implications
#13
Katarina Kalavska, Vincenza Conteduca, Ugo De Giorgi, Michal Mego
Testicular germ cell tumors (TGCTs) represent the most common malignancy in men aged 15-35. Due to these tumors' biological and clinical characteristics, they can serve as an appropriate system for studying molecular mechanisms associated with cisplatin-based treatment resistance. This review describes treatment resistance from clinical and molecular viewpoints. Cisplatin resistance is determined by various biological mechanisms, including the modulation of the DNA repair capacity of cancer cells, alterations to apoptotic cell death pathways, deregulation of gene expression pathways, epigenetic alterations and insufficient DNA binding...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29289361/the-pathobiology-of-primary-testicular-diffuse-large-b-cell-lymphoma-implications-for-novel-therapies
#14
REVIEW
David D W Twa, Anja Mottok, Kerry J Savage, Christian Steidl
Primary testicular lymphomas (PTL) are the most prevalent type of testicular cancer arising in men over the age of 60. PTL accounts for approximately 1-2% of all non-Hodgkin lymphomas and most present with localized disease but despite this, outcome is poor. The majority of cases represent an extranodal manifestation of diffuse large B-cell lymphoma (DLBCL), known as primary testicular DLBCL (PT-DLBCL). Gene expression profiling has established that over 75% of PT-DLBCLs resemble the activated B-cell-like (ABC) or non-germinal center subtype of nodal DLBCL...
December 20, 2017: Blood Reviews
https://www.readbyqxmd.com/read/29288790/satisfaction-with-testicular-prosthesis-after-radical-orchiectomy
#15
Thomas G Clifford, Madeleine L Burg, Brian Hu, Jeffrey Loh-Doyle, Cory M Hugen, Jie Cai, Hooman Djaladat, Kevin Wayne, Siamak Daneshmand
OBJECTIVES: To determine patient satisfaction with testicular prostheses (TP) for testicular cancer. Reconstruction represents an important part of surgical oncology, yet placement of TP following orchiectomy is infrequently performed. Improved data on patient satisfaction with TP would help in counseling patients with testicular cancer. METHODS: Forty patients who underwent orchiectomy and TP placement for testicular cancer participated in a survey that was blinded to the providers in an outpatient clinic (2012-2014) to evaluate TP satisfaction...
December 27, 2017: Urology
https://www.readbyqxmd.com/read/29279691/recurrent-masses-after-testicular-cancer-growing-teratoma-syndrome-a-case-report-and-review-of-the-literature
#16
Fanny Priod, Francis Lorge, Marcelo Di Gregorio, Michaël V Dupont, Marie-Cécile Nollevaux, Laurence Faugeras, Georges Lawson, Philippe Eucher, Lionel D'Hondt
Background: Growing teratoma syndrome is a rare syndrome that affects patients with nonseminomatous germ-cell tumors (NSGCTs). It is characterized by recurrent growing masses that appear during or after chemotherapy in the presence of normal levels of tumor markers. Histological examination is the only way to confirm the diagnosis. Case Presentation: We present the case of a 36-year-old man who developed recurrent masses after curative treatment for NSGCT of the testicle...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29279100/long-term-toxicity-of-the-treatment-for-germ-cell-cancer-a-review
#17
REVIEW
P Maroto, G Anguera, C Martin
Testicular germ-cell cancer (GCC) is a curable disease. Stage I patients are mostly cured by surgery alone. For those with good prognosis advanced disease, radiotherapy in some patients with stage II Seminoma and chemotherapy for all other patients, are responsible for 95% of long-term survivors. Unfortunately, despite this high level of curability, overall survival has been reported lower for those patients receiving either radiotherapy or chemotherapy versus patients treated by surgery alone. Long-term survivors face a higher incidence of second neoplasms, and a higher risk of cardiovascular disease and metabolic syndrome than expected...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29276802/comparison-of-tissue-stiffness-using-shear-wave-elastography-in-men-with-normal-testicular-tissue-testicular-microlithiasis-and-testicular-cancer
#18
Malene Roland Pedersen, Henrik Møller, Palle Jørn Sloth Osther, Peter Vedsted, René Holst, Søren Rafael Rafaelsen
Objectives: To compare elastography measurements in men with normal testicular tissue, testicular microlithiasis and testicular cancer. Methods: A total of 248 consecutive patients were included. All men provided written informed consent. Testicular stiffness was assessed using shear wave elastography (SWE). Three SWE velocity measurements were assessed in each testicle. The patients were divided into three groups; men with normal testicular tissue (n=130), men with testicular microlithiasis (n=99) and men with testicular cancer (n=19)...
September 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/29259484/semen-cryopreservation-as-an-oncofertility-treatment-in-122-japanese-men-with-cancer-a-decade-long-study
#19
Hideyuki Kobayashi, Koji Tamura, Toshihiro Tai, Koichi Nagao, Koichi Nakajima
Purpose: Oncofertility is a subspecialty that is concerned with helping patients with cancer preserve their ability to have children in the future. For men, sperm banking is an established way to preserve fertility. The aim was to determine the prefreeze semen characteristics and reproductive outcomes according to cancer type for men who chose semen cryopreservation. Methods: The records of 122 men with cancer who requested semen cryopreservation at the authors' hospital from 2006 to 2015 were reviewed...
October 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29259474/fertility-preservation-of-patients-with-testicular-cancer
#20
REVIEW
Itsuto Hamano, Shingo Hatakeyama, Chikara Ohyama
Background: Testicular cancer (TC) is one of the most common malignancies in young men of reproductive age. Although TC is a curable malignancy with a high survival rate, its treatment requires various cytotoxic modalities and negatively impacts spermatogenesis; therefore, the fertility preservation of patients with TC has been studied. Methods: In order to give an overview of fertility preservation in patients with TC, the literature was reviewed. Original and review articles were identified and examined on the basis of PubMed database searches...
July 2017: Reproductive Medicine and Biology
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