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https://www.readbyqxmd.com/read/28929714/-extending-traceability-of-malignant-testicular-tumours-using-hospital-discharge-records-an-experience-in-veneto-region-northern-italy
#1
Mario Saugo, Giuseppe Mastrangelo, Gianstefano Blengio, Gianferruccio Righetto
OBJECTIVES: validation of codes of hospital discharge records (SDO) for identification of new cases of malignant testicular tumour in the Veneto Region (Northern Italy). DESIGN: record linkage between the regional archive of SDO and the archive of the Veneto Tumour Registry (VTR). SETTING AND PARTICIPANTS: extraction of cases from SDO source with ICD-9-CM 186 code for diagnosis and 62.3-62.4 codes for surgical procedure, and from VTR database using ICD-O-3 C62 code for site and 9060-9062, 9064-9066, 9070, 9071, 9080-9083, 9085, 9100, 9101 codes for morphology, with 5th digit behaviour code equal to "/3"...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28926831/multiparameter-investigation-of-a-46-xx-46-xy-tetragametic-chimeric-phenotypical-male-patient-with-bilateral-scrotal-ovotestes-and-ovulatory-activity
#2
Yolande van Bever, Katja P Wolffenbuttel, Hennie T Brüggenwirth, Eric Blom, Annelies de Klein, Bert H J Eussen, Florijn van der Windt, Sabine E Hannema, Arianne B Dessens, Lambert C J Dorssers, Katharina Biermann, Remko Hersmus, Yolanda B de Rijke, Leendert H J Looijenga
We report on an adult male initially presenting with gynecomastia and a painless scrotal mass without additional genital anomalies. Hyperpigmentation of the skin following the Blaschko's lines was identified. He underwent gonadectomy because of suspected cancer. Histological analyses revealed an ovotestis with ovulatory activity confirmed by immunohistochemistry with multiple markers. Karyotyping of cultured peripheral blood lymphocytes and a buccal smear revealed a 46,XX/46,XY chimeric constitution with different percentages...
September 20, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28918178/using-imaging-to-predict-treatment-response-in-genitourinary-malignancies
#3
REVIEW
Amir H Lebastchi, Matthew J Watson, Christopher M Russell, Arvin K George, Alon Z Weizer, Baris Turkbey
CONTEXT: Over the previous2 decades, there have been numerous advancements in the diagnostic evaluation, therapeutic management, and postoperative assessment of genitourinary malignancies. OBJECTIVE: To present a review of current and novel imaging modalities and their utility in the assessment of therapeutic response in the systemic management of renal, testicular, and prostate cancers. EVIDENCE ACQUISITION: A PubMed/Medline search of the current published literature inclusive of prospective and retrospective original research, systematic reviews, and meta-analyses was conducted evaluating imaging modalities for renal cell carcinoma, prostate cancer, and testicular cancer...
September 13, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28904904/scrotal-reconstruction-and-testicular-prosthetics
#4
REVIEW
Jacob W Lucas, Kyle M Lester, Andrew Chen, Jay Simhan
Scrotal surgery encompasses a wide-variety of surgical techniques for an even wider variety of indications. In this manuscript, we review our indications, techniques, and pit-falls for various reconstructive scrotal surgeries as-well-as surgical tips for placement of testicular prostheses. Penoscrotal webbing (PSW) is an abnormal, often-problematic distal insertion of scrotal skin onto the ventral penile shaft. There are several effective and straightforward techniques used to revise this condition, which include simple scrotoplasty, single- or double-Z-plasty, or the VY-flap scrotoplasty...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28903372/myosin-va-plays-essential-roles-in-maintaining-normal-mitosis-enhancing-tumor-cell-motility-and-viability
#5
Yan-Ruide Li, Ai Zhong, Han Dong, Lu-Han Ni, Fu-Qing Tan, Wan-Xi Yang
Myosin Va, a member of Class V myosin, functions in organelle motility, spindle formation, nuclear morphogenesis and cell motility. The purpose of this study is to explore the expression and localization of myosin Va in testicular cancer and prostate cancer, and its specific roles in tumor progression including cell division, migration and proliferation. We detected myosin Va in testicular and prostate tumor tissues using sqRT-PCR, western blot, and immunofluorescence. Tumor samples showed an increased expression of myosin Va, abnormal actin and myosin Va distribution...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902733/131i-whole-body-scan-incidental-uptake-due-to-spermatocele
#6
Domenico Albano, Federica Motta, Carla Baronchelli, Silvia Lucchini, Francesco Bertagna
A 46-year-old man with papillary thyroid cancer post total thyroidectomy was referred for post radioiodine (I) whole-body scan. Whole-body images revealed intense I uptake in the bed thyroid and a focal abnormal uptake in the testicular area. Subsequent SPECT/CT demonstrated that the focal uptake corresponded to the left epididymis, and the pathology report revealed a spermatocele with no immunohistochemical features for thyroid tissue. Many cases of unexpected radioiodine uptake have been reported, and spermatocele could be counted for another possibility of incidental I uptake despite an unclear mechanism...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28902521/identification-of-novel-protein-expression-changes-following-cisplatin-treatment-and-application-to-combination-therapy
#7
Amy L Stark, Ashraf G Madian, Sawyer W Williams, Vincent Chen, Claudia Wing, Ronald J Hause, Lida Anita To, Amy L Gill, Jamie L Myers, Lidija K Gorsic, Mark F Ciaccio, Kevin P White, Richard B Jones, M Eileen Dolan
Determining the effect of chemotherapeutic treatment on changes in protein expression can provide important targets for overcoming resistance. Due to challenges in simultaneously measuring large numbers of proteins, a paucity of data exists on global changes. To overcome these challenges, we utilized microwestern arrays that allowed us to measure the abundance and modification state of hundreds of cell signaling and transcription factor proteins in cells following drug exposure. HapMap lymphoblastoid cell lines (LCLs) were exposed to cisplatin, a chemotherapeutic agent commonly used to treat testicular, head and neck, non-small cell lung, and gynecological cancers...
September 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28900777/an-exploration-of-genotype-phenotype-link-between-peutz-jeghers-syndrome-and-stk11-a-review
#8
REVIEW
Julian Daniell, John-Paul Plazzer, Anuradha Perera, Finlay Macrae
Peutz-Jeghers Syndrome (PJS) is an autosomal dominant hereditary polyposis syndrome. Clinical features include hamartomatous polyps, mucocutaneous pigmentation and an increased predisposition towards developing malignancy. Variants in STK11, a tumour suppressor gene, located on Chromosome 19, predispose to PJS. Peutz-Jeghers Syndrome is associated with increased rates of malignancy, particularly gastrointestinal. However, PJS is also associated with increased gynaecological, testicular and thyroid papillary malignancy...
September 12, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28900475/serum-biomarkers-to-predict-risk-of-testicular-and-penile-cancer-in-amoris
#9
Arunangshu Ghoshal, Hans Garmo, Rhonda Arthur, Niklas Hammar, Ingmar Jungner, Håkan Malmström, Mats Lambe, Göran Walldius, Mieke Van Hemelrijck
PURPOSE: To evaluate the association between commonly measured serum biomarkers of inflammation and penile and testicular cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. MATERIALS AND METHODS: A total of 205,717 subjects had baseline measurements of C-reactive protein, albumin, and haptoglobin. The association between quartiles and dichotomised values of inflammatory markers and penile and testicular cancer risk were analysed by using multivariate Cox proportional hazard models...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28893722/parental-occupational-exposure-to-organic-solvents-and-testicular-germ-cell-tumors-in-their-offspring-nord-test-study
#10
Charlotte Le Cornet, Béatrice Fervers, Eero Pukkala, Tore Tynes, Maria Feychting, Johnni Hansen, Kayo Togawa, Karl-Christian Nordby, Susanne Oksbjerg Dalton, Sanni Uuksulainen, Pernilla Wiebert, Torill Woldbæk, Niels E Skakkebæk, Ann Olsson, Joachim Schüz
BACKGROUND: Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development in utero. OBJECTIVES: We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring. METHODS: This registry-based case control study included TGCT cases aged 14-49 y (n=8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden...
June 30, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28881930/appendix-9-testicular-seminoma-and-non-seminoma-eupdate-published-online-29-june-2017-www-esmo-org-guidelines-genitourinary-cancers
#11
J Oldenburg, A Horwich
No abstract text is available yet for this article.
July 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28881587/mgmt-and-calca-promoter-methylation-are-associated-with-poor-prognosis-in-testicular-germ-cell-tumor-patients
#12
Camila Maria da Silva Martinelli, André van Helvoort Lengert, Flavio Mavignier Cárcano, Eduardo Caetano Albino Silva, Mariana Brait, Luiz Fernando Lopes, Daniel Onofre Vidal
Testicular germ cell tumors (TGCT) represent the second main cause of cancer-related death in young men. Despite high cure rates, refractory disease results in poor prognosis. Epigenetic reprogramming occurs during the development of seminomas and non-seminomas. Understanding the molecular and genetic basis of these tumors would represent an important advance in the search for new TGCT molecular markers. Hence the frequency of methylation of a gene panel (VGF, MGMT, ADAMTS1, CALCA, HOXA9, CDKN2B, CDO1 and NANOG) was evaluated in 72 primary TGCT by quantitative methylation specific PCR...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28876425/concomitant-testicular-infection-by-zika-virus-and-schistosoma-mansoni-in-a-brazilian-young-boy
#13
Leonardo Souza Alves, Cesar Estanislau, Lucio Barreto, Francisco Batista, Nivaldo Toppa
Sumary The identification of a escrotal mass without pain or report of trauma should be investigated to rule out scrotal cancer. We report the case of a young Brazilian boy who underwent orchiectomy after magnetic resonance imaging (MRI) and duplex scan (DS) indicating a high possibility of cancer. Blood exams ruled out the possibility of cancer. Testicular biopsy was not indicated. After surgery the diagnostic was extensive orchiepididymitis by Schistosoma. In endemic areas orchiepididymis by Schistosoma should be investigate to avoid unnecessary surgeries...
June 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28871003/association-between-rassf1a-promoter-methylation-and-testicular-germ-cell-tumor-a-meta-analysis-and-a-cohort-study
#14
Dora Markulin, Aleksandar Vojta, Ivana Samaržija, Marija Gamulin, Ivona Bečeheli, Irena Jukić, Čedomir Maglov, Vlatka Zoldoš, Aleksandra Fučić
BACKGROUND: The RAS association domain family protein 1a (RASSF1A) is a prominent tumor suppressor gene showing altered promoter methylation in testicular germ cell tumors (TGCT). RASSF1A promoter hypermethylation might represent an early event in TGCT tumorigenesis. We investigated whether the RASSF1A promoter methylation in peripheral blood of TGCT patients can be associated with testicular cancer risk. MATERIALS AND METHODS: Following a meta-analysis, we performed a cohort study including 32 testicular cancer patients and 32 healthy controls...
September 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28866371/no-longer-any-role-for-routine-follow-up-chest-x-rays-in-men-with-stage-i-germ-cell-cancer
#15
H De La Pena, A Sharma, C Glicksman, J Joseph, M Subesinghe, Z Traill, C Verrill, M Sullivan, J Redgwell, E Bataillard, E Pintus, N Dallas, A Gogbashian, M Tuthill, A Protheroe, M Hall
Following radical orchidectomy for testicular cancer, most patients undergo protocolled surveillance to detect tumour recurrences rather than receive adjuvant chemotherapy. Current United Kingdom national and most international guidelines recommend that patients require a chest x-ray (CXR) and serum tumour markers at each follow-up visit as well as regular CT scans; there is however, variation among cancer centres with follow-up protocols. Seminomas often do not cause tumour marker elevation; therefore, CT scans are the main diagnostic tool for detecting relapse...
August 31, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28854068/practice-makes-perfect-the-rest-of-the-story-in-testicular-cancer-as-a-model-curable-neoplasm
#16
Torgrim Tandstad, Christian K Kollmannsberger, Bruce J Roth, Claudio Jeldres, Silke Gillessen, Karim Fizazi, Siamak Daneshmand, William T Lowrance, Nasser H Hanna, Costantine Albany, Richard Foster, Gabriella Cohn Cedermark, Darren R Feldman, Thomas Powles, Mark A Lewis, Peter Scott Grimison, Douglas Bank, Christopher Porter, Peter Albers, Maria De Santis, Sandy Srinivas, George J Bosl, Craig R Nichols
No abstract text is available yet for this article.
August 30, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28851333/a-gonadotropin-releasing-hormone-antagonist-reduces-serum-adrenal-androgen-levels-in-prostate-cancer-patients
#17
Yoshiyuki Miyazawa, Yoshitaka Sekine, Takahiro Syuto, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
BACKGROUND: Adrenal androgens play an important role in the development of castration-resistant prostate cancer therapeutics. The effect of gonadotropin-releasing hormone (GnRH) antagonists on adrenal androgens has not been studied sufficiently. We measured testicular and adrenal androgen levels in patients treated with a GnRH antagonist. METHODS: This study included 47 patients with histologically proven prostate cancer. All of the patients were treated with the GnRH antagonist degarelix...
August 29, 2017: BMC Urology
https://www.readbyqxmd.com/read/28846983/indian-propolis-ameliorates-the-mitomycin-c-induced-testicular-toxicity-by-reducing-dna-damage-and-elevating-the-antioxidant-activity
#18
Sandhya Kumari, Guruprasad Nayak, Sonu T Lukose, Sneha Guruprasad Kalthur, Nandini Bhat, Aswathi R Hegde, Srinivas Mutalik, Guruprasad Kalthur, Satish Kumar Adiga
Development of excellent curative therapy for most of the malignancies has resulted in a growing population of cancer survivors who are at increased risk for a variety of health problems including infertility. Therefore, fertility preservation has become an important issue during cancer treatment in recent years. Combination therapy with natural agents such as vitamins, antioxidants, dietary supplements, and plant products are considered as an attractive option to mitigate normal tissue toxicity imparted by chemotherapy...
August 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28845050/preservation-of-fertility-or-ovarian-function-in-patients-with-breast-cancer-or-gynecologic-and-internal-malignancies
#19
Angrit Stachs, Steffi Hartmann, Bernd Gerber
Because of the efficacy of systemic therapies, neoplasias which occur in pediatric and adolescent patients and in young adults have high cure rates. This means that fulfilling their wish to have children has become a more pressing concern, particularly among young women with malignant tumors. Premature ovarian failure is also a not insignificant problem as it has a lasting detrimental effect on quality of life. Every oncology patient who may potentially wish to have children should be informed about their options for preserving fertility prior to starting treatment...
August 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28842431/testicular-cells-exhibit-similar-molecular-responses-to-cigarette-smoke-condensate-ex-vivo-and-in-vivo
#20
Prabagaran Esakky, Deborah A Hansen, Andrea M Drury, Paul Felder, Andrew Cusumano, Kelle H Moley
Male exposure to cigarette smoke is associated with seminal defects and with congenital anomalies and childhood cancers in offspring. In mice, paternal exposure to cigarette smoke condensate (CSC) causes molecular defects in germ cells and phenotypic effects in their offspring. Here we used an ex vivo testicular explant model and in vivo exposure to determine the concentration at which CSC impairs spermatogenesis and offspring development. We explanted testis tissue at postnatal day (P)5.5 and cultured it until P11...
August 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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