keyword
MENU ▼
Read by QxMD icon Read
search

Bank vole

keyword
https://www.readbyqxmd.com/read/27892798/transmissibility-of-gerstmann-str%C3%A3-ussler-scheinker-syndrome-in-rodent-models-new-insights-into-the-molecular-underpinnings-of-prion-infectivity
#1
Romolo Nonno, Michele Angelo Di Bari, Umberto Agrimi, Laura Pirisinu
Prion diseases, or transmissible spongiform encephalopathies, have revealed the bewildering phenomenon of transmissibility in neurodegenerative diseases. Hence, the experimental transmissibility of prion-like neurodegenerative diseases via template directed misfolding has become the focus of intense research. Gerstmann-Sträussler-Scheinker disease (GSS) is an inherited prion disease associated with mutations in the prion protein gene. However, with the exception of a few GSS cases with P102L mutation characterized by co-accumulation of protease-resistant PrP core (PrP(res)) of ∼21 kDa, attempts to transmit to rodents GSS associated to atypical misfolded prion protein with ∼8 kDa PrP(res) have been unsuccessful...
November 28, 2016: Prion
https://www.readbyqxmd.com/read/27880822/isolation-of-a-defective-prion-mutant-from-natural-scrapie
#2
Ilaria Vanni, Sergio Migliore, Gian Mario Cosseddu, Michele Angelo Di Bari, Laura Pirisinu, Claudia D'Agostino, Geraldina Riccardi, Umberto Agrimi, Romolo Nonno
It is widely known that prion strains can mutate in response to modification of the replication environment and we have recently reported that prion mutations can occur in vitro during amplification of vole-adapted prions by Protein Misfolding Cyclic Amplification on bank vole substrate (bvPMCA). Here we exploited the high efficiency of prion replication by bvPMCA to study the in vitro propagation of natural scrapie isolates. Although in vitro vole-adapted PrPSc conformers were usually similar to the sheep counterpart, we repeatedly isolated a PrPSc mutant exclusively when starting from extremely diluted seeds of a single sheep isolate...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27858312/isolation-and-complete-genome-characterization-of-novel-reassortant-orthoreovirus-from-common-vole-microtus-arvalis
#3
Enikő Fehér, Gábor Kemenesi, Miklós Oldal, Kornélia Kurucz, Renáta Kugler, Szilvia L Farkas, Szilvia Marton, Győző Horváth, Krisztián Bányai, Ferenc Jakab
A novel mammalian orthoreovirus (MRV) strain was isolated from the lung tissue of a common vole (Microtus arvalis) with Tula hantavirus infection. Seven segments (L1-L3, M2-M3, S2, and S4) of the Hungarian MRV isolate MORV/47Ma/06 revealed a high similarity with an MRV strain detected in bank vole (Myodes glareolus) in Germany. The M1 and S3 segment of the Hungarian isolate showed the closest relationship with the sequence of a Slovenian human and a French murine isolate, respectively. The highest nucleotide and amino acid identity values were above 90 and 95% in all of the comparisons to the reference sequences in GenBank, except for the S1 with a maximum of 69...
November 17, 2016: Virus Genes
https://www.readbyqxmd.com/read/27854567/metagenomic-evaluation-of-bacteria-from-voles
#4
Katja A Koskela, Laura Kalin-Mänttäri, Heidi Hemmilä, Teemu Smura, Paula M Kinnunen, Jukka Niemimaa, Heikki Henttonen, Simo Nikkari
Voles (Arvicolinae, Rodentia) are known carriers of zoonotic bacteria such as Bartonella spp. and Francisella tularensis. However, apart from F. tularensis, the bacterial microbiome of voles has not previously been determined in Finland and rarely elsewhere. Therefore, we studied liver samples from 61 voles using 16S ribosomal RNA gene PCR analysis, followed by Sanger sequencing. Twenty-three of these samples were also studied with tag-encoded pyrosequencing. The samples originated from 21 field voles (Microtus agrestis), 37 tundra voles (Microtus oeconomus), and 3 bank voles (Myodes glareolus)...
November 17, 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27815157/excretion-and-measurement-of-corticosterone-and-testosterone-metabolites-in-bank-voles-myodes-glareolus
#5
Saana Sipari, Hannu Ylönen, Rupert Palme
The bank vole is a commonly used model species in behavioral and ecophysiological studies. Thus, presenting a validated method for noninvasive monitoring of corticosterone and testosterone secretion is of high relevance. Here, we evaluated the effect of time of day and an ACTH challenge test on measured fecal corticosterone (FCM) and testosterone (FTM) metabolites in both sexes. Furthermore, we performed radiometabolism experiments for both steroids and sexes to study metabolism and excretion of (3)H-corticosterone and (3)H-testosterone...
November 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27806736/validation-of-the-puumala-virus-rapid-field-test-for-bank-voles-in-germany
#6
D Reil, C Imholt, U M Rosenfeld, S Drewes, S Fischer, E Heuser, R Petraityte-Burneikiene, R G Ulrich, J Jacob
Puumala virus (PUUV) causes many human infections in large parts of Europe and can lead to mild to moderate disease. The bank vole (Myodes glareolus) is the only reservoir of PUUV in Central Europe. A commercial PUUV rapid field test for rodents was validated for bank-vole blood samples collected in two PUUV-endemic regions in Germany (North Rhine-Westphalia and Baden-Württemberg). A comparison of the results of the rapid field test and standard ELISAs indicated a test efficacy of 93-95%, largely independent of the origin of the antigens used in the ELISA...
November 3, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27782121/de-novo-transcriptome-assembly-facilitates-characterisation-of-fast-evolving-gene-families-mhc-class-i-in-the-bank-vole-myodes-glareolus
#7
M Migalska, A Sebastian, M Konczal, P Kotlík, J Radwan
The major histocompatibility complex (MHC) plays a central role in the adaptive immune response and is the most polymorphic gene family in vertebrates. Although high-throughput sequencing has increasingly been used for genotyping families of co-amplifying MHC genes, its potential to facilitate early steps in the characterisation of MHC variation in nonmodel organism has not been fully explored. In this study we evaluated the usefulness of de novo transcriptome assembly in characterisation of MHC sequence diversity...
October 26, 2016: Heredity
https://www.readbyqxmd.com/read/27694145/a-borrelia-afzelii-infection-increases-larval-tick-burden-on-myodes-glareolus-rodentia-cricetidae-and-nymphal-body-weight-of-ixodes-ricinus-acari-ixodidae
#8
Gilian van Duijvendijk, Wouter van Andel, Manoj Fonville, Gerrit Gort, Joppe W Hovius, Hein Sprong, Willem Takken
Several microorganisms have been shown to manipulate their host or vector to enhance their own transmission. Here we examined whether an infection with Borrelia afzelii affects its transmission between its bank vole (Myodes glareolus, Schreber, 1780) host and tick vector. Captive-bred bank voles were inoculated with B. afzelii or control medium, after which host preference of Ixodes ricinus L. nymphs was determined in a Y-tube olfactometer. Thereafter, infected and uninfected bank voles were placed in a semifield arena containing questing larvae to measure larval tick attachment...
September 30, 2016: Journal of Medical Entomology
https://www.readbyqxmd.com/read/27687699/the-effect-of-aluminum-exposure-on-reproductive-ability-in-the-bank-vole-myodes-glareolus
#9
Agata Miska-Schramm, Joanna Kapusta, Małgorzata Kruczek
Human impact on the environment is steadily increasing the amounts of aluminum in the ecosystems. This element accumulates in plants and water, potentially exposing herbivores to its harmful effect. In heavily polluted sites, a decrease in the density of small rodent populations has been observed. This decline may be caused by many factors, including decreased fertility. The aim of the presented research was to determine how aluminum, administered at concentrations similar to those recorded in industrial districts (Al I = 3 mg/l, Al II = 200 mg/l), affects the reproductive abilities of small rodents...
September 29, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27632790/modification-of-nickel-accumulation-in-the-tissues-of-the-bank-vole-myodes-glareolus-by-chemical-and-environmental-factors
#10
Renata Świergosz-Kowalewska, Anita Tokarz
: In a full factorial laboratory experiment, the effects of temperature and two chemical stressors (nickel and chlorpyrifos) on the accumulation of nickel in the liver and kidney of bank voles were studied. The nine-week experiment consisted of three periods: acclimatisation (3 days), intoxication (6 weeks) and elimination (3 weeks). During the main intoxication phase the animals were orally exposed for 42 days to different doses of nickel (Ni) (0, 300 and 800mg/kg food) or chlorpyrifos (CPF) (0, 50 and 350mg/kg food) or a mixture of both chemicals...
September 12, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27576687/n-terminal-prion-protein-peptides-prp-120-144-form-parallel-in-register-%C3%AE-sheets-via-multiple-nucleation-dependent-pathways
#11
Yiming Wang, Qing Shao, Carol K Hall
The prion diseases are a family of fatal neurodegenerative diseases associated with the misfolding and accumulation of normal prion protein (PrP(C)) into its pathogenic scrapie form (PrP(Sc)). Understanding the fundamentals of prion protein aggregation and the molecular architecture of PrP(Sc) is key to unraveling the pathology of prion diseases. Our work investigates the early-stage aggregation of three prion protein peptides, corresponding to residues 120-144 of human (Hu), bank vole (BV), and Syrian hamster (SHa) prion protein, from disordered monomers to β-sheet-rich fibrillar structures...
October 14, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27499001/declining-ecosystem-health-and-the-dilution-effect
#12
Hussein Khalil, Frauke Ecke, Magnus Evander, Magnus Magnusson, Birger Hörnfeldt
The "dilution effect" implies that where species vary in susceptibility to infection by a pathogen, higher diversity often leads to lower infection prevalence in hosts. For directly transmitted pathogens, non-host species may "dilute" infection directly (1) and indirectly (2). Competitors and predators may (1) alter host behavior to reduce pathogen transmission or (2) reduce host density. In a well-studied system, we tested the dilution of the zoonotic Puumala hantavirus (PUUV) in bank voles (Myodes glareolus) by two competitors and a predator...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27498685/multiple-independent-transmission-cycles-of-a-tick-borne-pathogen-within-a-local-host-community
#13
Maude Jacquot, David Abrial, Patrick Gasqui, Severine Bord, Maud Marsot, Sébastien Masseglia, Angélique Pion, Valérie Poux, Laurence Zilliox, Jean-Louis Chapuis, Gwenaël Vourc'h, Xavier Bailly
Many pathogens are maintained by multiple host species and involve multiple strains with potentially different phenotypic characteristics. Disentangling transmission patterns in such systems is often challenging, yet investigating how different host species contribute to transmission is crucial to properly assess and manage disease risk. We aim to reveal transmission cycles of bacteria within the Borrelia burgdorferi species complex, which include Lyme disease agents. We characterized Borrelia genotypes found in 488 infected Ixodes ricinus nymphs collected in the Sénart Forest located near Paris (France)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27439091/bank-voles-accrue-scientific-interest
#14
Gregory D Larsen
No abstract text is available yet for this article.
July 20, 2016: Lab Animal
https://www.readbyqxmd.com/read/27408800/reduced-helminth-parasitism-in-the-introduced-bank-vole-myodes-glareolus-more-parasites-lost-than-gained
#15
Karen C Loxton, Colin Lawton, Peter Stafford, Celia V Holland
Introduced species are often less parasitised compared to their native counterparts and to ecologically similar hosts in the new environment. Reduced parasitism may come about due to both the loss of original parasites and low acquisition of novel parasites. In this study we investigated the intestinal helminth parasites of the introduced bank vole (Myodes glareolus) in Ireland. Results were compared to data from other European studies and to the intestinal helminth fauna of an ecologically similar native rodent in Ireland, the wood mouse (Apodemus sylvaticus)...
August 2016: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/27401229/genomic-response-to-selection-for-predatory-behavior-in-a-mammalian-model-of-adaptive-radiation
#16
Mateusz Konczal, Paweł Koteja, Patrycja Orlowska-Feuer, Jacek Radwan, Edyta T Sadowska, Wiesław Babik
If genetic architectures of various quantitative traits are similar, as studies on model organisms suggest, comparable selection pressures should produce similar molecular patterns for various traits. To test this prediction, we used a laboratory model of vertebrate adaptive radiation to investigate the genetic basis of the response to selection for predatory behavior and compare it with evolution of aerobic capacity reported in an earlier work. After 13 generations of selection, the proportion of bank voles (Myodes [=Clethrionomys] glareolus) showing predatory behavior was five times higher in selected lines than in controls...
September 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/27400975/evolutionary-conflict-between-maternal-and-paternal-interests-integration-with-evolutionary-endocrinology
#17
Mikael Mokkonen, Esa Koskela, Tapio Mappes, Suzanne C Mills
Conflict between mates, as well as conflict between parents and offspring are due to divergent evolutionary interests of the interacting individuals. Hormone systems provide genetically based proximate mechanisms for mediating phenotypic adaptation and maladaptation characteristic of evolutionary conflict between individuals. Testosterone (T) is among the most commonly studied hormones in evolutionary biology, and as such, its role in shaping sexually dimorphic behaviors and physiology is relatively well understood, but its role in evolutionary conflict is not as clear...
August 2016: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/27380876/multi-host-bartonella-parasites-display-covert-host-specificity-even-when-transmitted-by-generalist-vectors
#18
Susan M Withenshaw, Godefroy Devevey, Amy B Pedersen, Andy Fenton
Many parasites infect multiple sympatric host species and there is a general assumption that parasite transmission between co-occurring host species is commonplace. Such between-species transmission could be key to parasite persistence within a disease reservoir and is consequently an emerging focus for disease control. However, while a growing body of theory indicates the potential importance of between-species transmission for parasite persistence, conclusive empirical evidence from natural communities is lacking, and the assumption that between-species transmission is inevitable may therefore be wrong...
July 6, 2016: Journal of Animal Ecology
https://www.readbyqxmd.com/read/27371812/increased-autumn-rainfall-disrupts-predator-prey-interactions-in-fragmented-boreal-forests
#19
Julien Terraube, Alexandre Villers, Léo Poudré, Rauno Varjonen, Erkki Korpimäki
There is a pressing need to understand how changing climate interacts with land-use change to affect predator-prey interactions in fragmented landscapes. This is particularly true in boreal ecosystems facing fast climate change and intensification in forestry practices. Here, we investigated the relative influence of autumn climate and habitat quality on the food-storing behaviour of a generalist predator, the pygmy owl, using a unique dataset of 15850 prey items recorded in western Finland over 12 years. Our results highlighted strong effects of autumn climate (number of days with rainfall and with temperature<0°C) on food-store composition...
July 2, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27350609/towards-authentic-transgenic-mouse-models-of-heritable-prp-prion-diseases
#20
Joel C Watts, Kurt Giles, Matthew E C Bourkas, Smita Patel, Abby Oehler, Marta Gavidia, Sumita Bhardwaj, Joanne Lee, Stanley B Prusiner
Attempts to model inherited human prion disorders such as familial Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker (GSS) disease, and fatal familial insomnia (FFI) using genetically modified mice have produced disappointing results. We recently demonstrated that transgenic (Tg) mice expressing wild-type bank vole prion protein (BVPrP) containing isoleucine at polymorphic codon 109 develop a spontaneous neurodegenerative disorder that exhibits many of the hallmarks of prion disease. To determine if mutations causing inherited human prion disease alter this phenotype, we generated Tg mice expressing BVPrP containing the D178N mutation, which causes FFI; the E200K mutation, which causes familial CJD; or an anchorless PrP mutation similar to mutations that cause GSS...
October 2016: Acta Neuropathologica
keyword
keyword
31309
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"