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https://www.readbyqxmd.com/read/29434310/recombinant-ifn-%C3%AE-from-the-bank-vole-myodes-glareolus-a-novel-tool-for-research-on-rodent-reservoirs-of-zoonotic-pathogens
#1
Francesca Torelli, Steffen Zander, Heinz Ellerbrok, Georg Kochs, Rainer G Ulrich, Christian Klotz, Frank Seeber
Rodent species like Myodes glareolus and Microtus spp. are natural reservoirs for many zoonotic pathogens causing human diseases and are gaining increasing interest in the field of eco-immunology as candidate animal models. Despite their importance the lack of immunological reagents has hampered research in these animal species. Here we report the recombinant production and functional characterization of IFN-γ, a central mediator of host's innate and adaptive immune responses, from the bank vole M. glareolus...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29404206/spatial-and-temporal-patterns-of-human-puumala-virus-puuv-infections-in-germany
#2
Sarah Cunze, Judith Kochmann, Thomas Kuhn, Raphael Frank, Dorian D Dörge, Sven Klimpel
Background: Worldwide, the number of recorded human hantavirus infections as well as the number of affected countries is on the rise. In Europe, most human hantavirus infections are caused by the Puumala virus (PUUV), with bank voles (Myodes glareolus) as reservoir hosts. Generally, infection outbreaks have been related to environmental conditions, particularly climatic conditions, food supply for the reservoir species and land use. However, although attempts have been made, the insufficient availability of environmental data is often hampering accurate temporal and spatially explicit models of human hantavirus infections...
2018: PeerJ
https://www.readbyqxmd.com/read/29396672/copper-influence-on-bank-vole-s-myodes-glareolus-sexual-behavior
#3
Agata Miska-Schramm, Joanna Kapusta, Małgorzata Kruczek
The impact of human activity on the environment has led to a steady increase of the amounts of copper in the ecosystems. This element accumulates in plants and water, potentially exposing rodents to its harmful effects. In industrial districts, a decrease in the density of small rodent populations has been observed. This decline may be caused by many factors, including mortality, decreased fertility, or impaired sexual behavior. The decline in the reproductive abilities of small rodents after copper exposure was demonstrated in our previous work (Miska-Schramm A, Kruczek M, Kapusta J, Ecotoxicology 23:1546-1554, 2014)...
February 2, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29385212/recombinant-prpsc-shares-structural-features-with-brain-derived-prpsc-insights-from-limited-proteolysis
#4
Alejandro M Sevillano, Natalia Fernández-Borges, Neelam Younas, Fei Wang, Saioa R Elezgarai, Susana Bravo, Ester Vázquez-Fernández, Isaac Rosa, Hasier Eraña, David Gil, Sonia Veiga, Enric Vidal, Melissa L Erickson-Beltran, Esteban Guitián, Christopher J Silva, Romolo Nonno, Jiyan Ma, Joaquín Castilla, Jesús R Requena
Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the β-strands and connecting loops that make up the PrPSc solenoid. Using high resolution SDS-PAGE followed by epitope analysis, and mass spectrometry, we identified positions ~116/118, 133-134, 141, 152-153, 162, 169 and 179 (murine numbering) as Proteinase K (PK) cleavage sites in PrPSc. Such sites likely define loops and/or borders of β-strands, helping us to predict the threading of the β-solenoid...
January 31, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29335561/sub-%C3%A3-ngstr%C3%A3-m-cryo-em-structure-of-a-prion-protofibril-reveals-a-polar-clasp
#5
Marcus Gallagher-Jones, Calina Glynn, David R Boyer, Michael W Martynowycz, Evelyn Hernandez, Jennifer Miao, Chih-Te Zee, Irina V Novikova, Lukasz Goldschmidt, Heather T McFarlane, Gustavo F Helguera, James E Evans, Michael R Sawaya, Duilio Cascio, David S Eisenberg, Tamir Gonen, Jose A Rodriguez
The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-ångström-resolution structure of a protofibril formed by a wild-type segment from the β2-α2 loop of the bank vole prion protein. The structure of this protofibril reveals a stabilizing network of hydrogen bonds that link polar zippers within a sheet, producing motifs we have named 'polar clasps'.
January 15, 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29248947/variation-of-metallothionein-i-and-ii-gene-expression-in-the-bank-vole-clethrionomys-glareolus-under-environmental-zinc-and-cadmium-exposure
#6
Magdalena Mikowska, Barbara Dziublińska, Renata Świergosz-Kowalewska
The main idea of the study was to assess how environmental metal pollution activates defence responses at transcription levels in the tissues of bank voles (Clethrionomys glareolus). For this purpose, the metallothioneine (MT) genes expression (a well known biomarker of exposure and response to various metals) was measured. The real-time PCR method was used for relative quantification of metallothionein I and metallothionein II expressions in the livers, kidneys and testes of bank voles from six populations exposed to different contaminants, mainly zinc, cadmium and iron...
December 16, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29237850/stabilizing-selection-on-microsatellite-allele-length-at-arginine-vasopressin-1a-receptor-and-oxytocin-receptor-loci
#7
Phillip C Watts, Eva R Kallio, Esa Koskela, Eija Lonn, Tapio Mappes, Mikael Mokkonen
The loci arginine vasopressin receptor 1a (avpr1a) and oxytocin receptor (oxtr) have evolutionarily conserved roles in vertebrate social and sexual behaviour. Allelic variation at a microsatellite locus in the 5' regulatory region of these genes is associated with fitness in the bank vole Myodes glareolus Given the low frequency of long and short alleles at these microsatellite loci in wild bank voles, we used breeding trials to determine whether selection acts against long and short alleles. Female bank voles with intermediate length avpr1a alleles had the highest probability of breeding, while male voles whose avpr1a alleles were very different in length had reduced probability of breeding...
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29169405/atypical-creutzfeldt-jakob-disease-with-prp-amyloid-plaques-in-white-matter-molecular-characterization-and-transmission-to-bank-voles-show-the-m1-strain-signature
#8
Marcello Rossi, Daniela Saverioni, Michele Di Bari, Simone Baiardi, Afina Willemina Lemstra, Laura Pirisinu, Sabina Capellari, Annemieke Rozemuller, Romolo Nonno, Piero Parchi
Amyloid plaques formed by abnormal prion protein (PrPSc) aggregates occur with low frequency in Creutzfeldt-Jakob disease, but represent a pathological hallmark of three relatively rare disease histotypes, namely variant CJD, sporadic CJDMV2K (methionine/valine at PRNP codon 129, PrPSc type 2 and kuru-type amyloid plaques) and iatrogenic CJDMMiK (MM at codon 129, PrPSc of intermediate type and kuru plaques). According to recent studies, however, PrP-amyloid plaques involving the subcortical and deep nuclei white matter may also rarely occur in CJDMM1 (MM at codon 129 and PrPSc type 1), the most common CJD histotype...
November 23, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29151870/elevated-mitochondrial-genome-variation-after-50-generations-of-radiation-exposure-in-a-wild-rodent
#9
Robert J Baker, Benjamin Dickins, Jeffrey K Wickliffe, Faisal A A Khan, Sergey Gaschak, Kateryna D Makova, Caleb D Phillips
Currently, the effects of chronic, continuous low dose environmental irradiation on the mitochondrial genome of resident small mammals are unknown. Using the bank vole (Myodes glareolus) as a model system, we tested the hypothesis that approximately 50 generations of exposure to the Chernobyl environment has significantly altered genetic diversity of the mitochondrial genome. Using deep sequencing, we compared mitochondrial genomes from 131 individuals from reference sites with radioactive contamination comparable to that present in northern Ukraine before the 26 April 1986 meltdown, to populations where substantial fallout was deposited following the nuclear accident...
September 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29129019/genetic-characterization-of-bank-vole-virus-bavv-a-new-paramyxovirus-isolated-from-kidneys-of-bank-voles-in-russia
#10
Sergey Alkhovsky, Alexander Butenko, Aykaz Eremyan, Alexey Shchetinin
A genome of bank vole virus (BaVV), isolated from kidney tissues of bank voles (Myodes glareolus) in Russia in 1973, was sequenced. The genomic organization of BaVV (3'-N-P/V/C-M-F-G-L-5', 16,992 nt in length; GenBank accession number MF943130) is most similar to that of Mossman virus (MoV) and Nariva virus (NarPV), two ungrouped paramyxoviruses isolated from rodents in Australia and Trinidad, respectively. The proteins of BaVV have the highest level of sequence identity (ranging from 23-28% for G protein to 66-73% for M protein) to proteins of MoV and NarPV...
November 11, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29079088/seasonal-shift-of-diet-in-bank-voles-explains-trophic-fate-of-anthropogenic-osmium
#11
Frauke Ecke, Åsa M M Berglund, Ilia Rodushkin, Emma Engström, Nicola Pallavicini, Dieke Sörlin, Erik Nyholm, Birger Hörnfeldt
Diet shifts are common in mammals and birds, but little is known about how such shifts along the food web affect contaminant exposure. Voles are staple food for many mammalian and avian predators. There is therefore a risk of transfer of contaminants accumulated in voles within the food chain. Osmium is one of the rarest earth elements with osmium tetroxide (OsO4) as the most toxic vapor-phase airborne contaminant. Anthropogenic OsO4 accumulates in fruticose lichens that are important winter food of bank voles (Myodes glareolus)...
October 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29035861/the-molecular-identification-of-calodium-hepaticum-in-the-wild-brown-rat-rattus-norvegicus-in-poland
#12
Katarzyna Buńkowska-Gawlik, Agnieszka Perec-Matysiak, Klaudia Burzyńska, Joanna Hildebrand
Calodium hepaticum is a parasitic nematode found primarily in rodents but known to infect numerous other mammal species, and causing in humans the hepatic calodiasis. Herein, we present the first finding of C. hepaticum in Rattus norvegicus in Poland. In this study, we have used the combined pepsin-HCl digestion and molecular techniques to detect C. hepaticum infection in the liver. The results confirm the usefulness of molecular approaches for investigating the biology and epidemiology of C. hepaticum. Additionally in this study, the parts of the small subunit rRNA (18S rRNA) gene of Aonchotheca annulosa from bank vole, Aonchotheca erinacei and Eucoleus sp...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28986730/acute-hantavirus-infection-presenting-as-haemolytic-uraemic-syndrome-hus-the-importance-of-early-clinical-diagnosis
#13
J Clement, A P K Lee, G A Verpooten, L Laenen, V Vergote, H De Samblanx, Z N Berneman, M Van Ranst, P Maes
The European prototype of hantavirus, Puumala virus (PUUV), isolated from a common wild rodent, the bank vole (Myodes glareolus), causes nephropathia epidemica (NE). NE can perfectly mimic haemolytic-uraemic syndrome (HUS), progressing from an aspecific flu-like syndrome to acute kidney injury with thrombocytopaenia, and presenting with some signs of haemolytic anaemia and/or coagulopathy. Moreover, both NE and HUS can occur in local outbreaks. We report an isolated case of NE, initially referred for plasmapheresis for suspected HUS, although signs of overt haemolysis were lacking...
January 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28978309/soluble-polymorphic-bank-vole-prion-proteins-induced-by-co-expression-of-quiescin-sulfhydryl-oxidase-in-e-coli-and-their-aggregation-behaviors
#14
Romany Abskharon, Johnny Dang, Ameer Elfarash, Zerui Wang, Pingping Shen, Lewis S Zou, Sedky Hassan, Fei Wang, Hisashi Fujioka, Jan Steyaert, Mentor Mulaj, Witold K Surewicz, Joaquín Castilla, Alexandre Wohlkonig, Wen-Quan Zou
BACKGROUND: The infectious prion protein (PrP(Sc) or prion) is derived from its cellular form (PrP(C)) through a conformational transition in animal and human prion diseases. Studies have shown that the interspecies conversion of PrP(C) to PrP(Sc) is largely swayed by species barriers, which is mainly deciphered by the sequence and conformation of the proteins among species. However, the bank vole PrP(C) (BVPrP) is highly susceptible to PrP(Sc) from different species. Transgenic mice expressing BVPrP with the polymorphic isoleucine (109I) but methionine (109M) at residue 109 spontaneously develop prion disease...
October 4, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28931606/asparagine-and-glutamine-ladders-promote-cross-species-prion-conversion
#15
Timothy D Kurt, Patricia Aguilar-Calvo, Lin Jiang, José A Rodriguez, Nazilla Alderson, David S Eisenberg, Christina J Sigurdson
Prion transmission between species is governed in part by primary sequence similarity between the infectious prion aggregate, PrP(Sc), and the cellular prion protein of the host, PrP(C) A puzzling feature of prion formation is that certain PrP(C) sequences, such as that of bank vole, can be converted by a remarkably broad array of different mammalian prions, whereas others, such as rabbit, show robust resistance to cross-species prion conversion. To examine the structural determinants that confer susceptibility or resistance to prion conversion, we systematically tested over 40 PrP(C) variants of susceptible and resistant PrP(C) sequences in a prion conversion assay...
September 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28931451/bank-vole-immunoheterogeneity-may-limit-nephropatia-epidemica-emergence-in-a-french-non-endemic-region
#16
A Dubois, G Castel, S Murri, C Pulido, J-B Pons, L Benoit, A Loiseau, L Lakhdar, M Galan, P Marianneau, N Charbonnel
Ecoevolutionary processes affecting hosts, vectors and pathogens are important drivers of zoonotic disease emergence. In this study, we focused on nephropathia epidemica (NE), which is caused by Puumala hantavirus (PUUV) whose natural reservoir is the bank vole, Myodes glareolus. We questioned the possibility of NE emergence in a French region that is considered to be NE-free but that is adjacent to a NE-endemic region. We first confirmed the epidemiology of these two regions and we demonstrated the absence of spatial barriers that could have limited dispersal, and consequently, the spread of PUUV into the NE-free region...
September 21, 2017: Parasitology
https://www.readbyqxmd.com/read/28878040/glareosin-a-novel-sexually-dimorphic-urinary-lipocalin-in-the-bank-vole-myodes-glareolus
#17
Grace M Loxley, Jennifer Unsworth, Michael J Turton, Alexandra Jebb, Kathryn S Lilley, Deborah M Simpson, Daniel J Rigden, Jane L Hurst, Robert J Beynon
The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleucine ambiguity was completely resolved by metabolic labelling, monitoring the incorporation of dietary deuterated leucine into specific sites in the protein. The predicted mass of the sequenced protein was exactly consonant with the mass of the protein measured in bank vole urine samples, correcting for the formation of two disulfide bonds...
September 2017: Open Biology
https://www.readbyqxmd.com/read/28870264/cryptosporidium-infecting-wild-cricetid-rodents-from-the-subfamilies-arvicolinae-and-neotominae
#18
Brianna L S Stenger, Michaela Horčičková, Mark E Clark, Martin Kváč, Šárka Čondlová, Eakalak Khan, Giovanni Widmer, Lihua Xiao, Catherine W Giddings, Christopher Pennil, Michal Stanko, Bohumil Sak, John M McEvoy
We undertook a study on Cryptosporidium spp. in wild cricetid rodents. Fecal samples were collected from meadow voles (Microtus pennsylvanicus), southern red-backed voles (Myodes gapperi), woodland voles (Microtus pinetorum), muskrats (Ondatra zibethicus) and Peromyscus spp. mice in North America, and from bank voles (Myodes glareolus) and common voles (Microtus arvalis) in Europe. Isolates were characterized by sequence and phylogenetic analyses of the small subunit ribosomal RNA (SSU) and actin genes. Overall, 33·2% (362/1089) of cricetids tested positive for Cryptosporidium, with a greater prevalence in cricetids from North America (50·7%; 302/596) than Europe (12·1%; 60/493)...
September 5, 2017: Parasitology
https://www.readbyqxmd.com/read/28852943/comparative-stylostome-ultrastructure-of-hirsutiella-zachvatkini-trombiculidae-and-trombidium-holosericeum-trombidiidae-larvae
#19
Andrey B Shatrov, Magdalena Felska
Stylostomes (feeding tubes) of Hirsutiella zachvatkini (Schluger) (Trombiculidae), feeding on bank voles [Myodes glareolus (Schreber)], and of Trombidium holosericeum (L.) (Trombidiidae), feeding on larvae of Stenodemini sp. (Heteroptera, Miridae), were studied by TEM methods and on semi-thin sections. The stylostome of H. zachvatkini is a homogeneous structure of low electron density and without strict margins. It extends within the concave host epidermis, undergoing hyperplasia and hyperkeratosis. TEM does not reveal any obvious stratification in the stylostome walls...
August 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28820402/does-signaling-of-estrogen-related-receptors-affect-structure-and-function-of-bank-vole-leydig-cells
#20
P Pawlicki, A Milon, M Zarzycka, J Galas, W Tworzydlo, A Kaminska, L Pardyak, K Lesniak, A Pacwa, B Bilinska, E Gorowska-Wojtowicz, M Kotula-Balak
To get a deeper insight into the function of estrogen-related receptors (ERRs) and dissect underlying mechanism in Leydig cells, ERRs (type α, β and γ) were blocked or activated in testes of adult bank voles (Myodes glareolus) which show seasonal changes in the intratesticular sex hormones level. Both actively reproducing animals (long day conditions; LD) and those with regression of the reproductive system (short day conditions; SD) received intraperitoneal injections of selective ERRα antagonist 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide (XCT 790) or selective ERRβ/ERRγ agonist N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine (DY131) (50 μ/kg bw; six doses every other day)...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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