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https://www.readbyqxmd.com/read/28631213/the-constitutive-protease-release-by-primary-human-acute-myeloid-leukemia-cells
#1
Maria Honnemyr, Øystein Bruserud, Annette K Brenner
INTRODUCTION: Acute myeloid leukemia (AML) cells show constitutive release of matrix metalloproteases and their inhibitors. We now investigated this constitutive release of protease/protease regulators associated with carcinogenesis (ADAM12, uPA, cystatin B), angiogenesis (serpin E1, uPA, CD147), cancer cell migration (uPA, cystatin C), coagulation (ADAM TS13, serpin C1), inflammation (fetuin A, caspase 1, cystatin C), monocytic differentiation (CFD) or regulation of hematopoiesis (neutrophil elastase)...
June 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28630003/effects-of-mild-calorie-restriction-on-lipid-metabolism-and-inflammation-in-liver-and-adipose-tissue
#2
Chan Yoon Park, Soyoung Park, Min Soo Kim, Hye-Kyeong Kim, Sung Nim Han
Calorie restriction (CR) has been reported to improve lipid metabolism and to decrease inflammatory diseases. However, most existing CR models use 30-50% calorie reduction, which is hard to achieve in humans. We investigated the effects of mild CR on lipid metabolism and inflammatory responses. Male C57BL/6 mice were fed control diet (10% kcal fat, Control) or high fat diet (60% kcal fat, HFD) ad libitum or reduced amount of control diet to achieve 15% CR for 16 wks. Body weights, white adipose tissue weights, liver triacylglycerol levels, and serum fetuin-A levels were lower in CR than in the Control...
June 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28622050/serum-and-aqueous-humor-levels-of-fetuin-a-in-pseudoexfoliation-syndrome
#3
Nilay Yuksel, Tamer Takmaz, Ummuhani Ozel Turkcu, Merve Ergin, Hasan Altinkaynak, Ayse Bilgihan
PURPOSE: To evaluate serum and aqueous humor levels of fetuin-A in patients with pseudoexfoliation syndrome (PEXS) in comparison with those of age- and sex-matched healthy subjects. MATERIALS AND METHODS: This prospective study included 25 patients with PEXS and 25 control subjects who were undergoing cataract surgery without any systemic or ocular disease. Aqueous humor and serum fetuin-A levels were measured with enzyme-linked immunosorbent assay method. RESULTS: The mean age of the PEXS group (14 males, 11 females, n = 25) was 57...
June 16, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28621339/hepatokines-linking-nonalcoholic-fatty-liver-disease-and-insulin-resistance
#4
REVIEW
Ruth C R Meex, Matthew J Watt
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver disease and is present in up to ∼70% of individuals who are overweight. NAFLD is also associated with hypertriglyceridaemia and low levels of HDL, glucose intolerance, insulin resistance and type 2 diabetes mellitus. Hepatic steatosis is a strong predictor of the development of insulin resistance and often precedes the onset of other known mediators of insulin resistance. This sequence of events suggests that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as skeletal muscle...
June 9, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28590116/facile-and-selective-enrichment-of-intact-sialoglycopeptides-using-graphitic-carbon-nitride
#5
Mo Zhang, Yujie Liu, Dan Zhang, Tianjing Chen, Zhili Li
Combining powerful selectivity, high stability, convenient operation, mild condition, and eco-friendliness, a novel graphitic carbon nitride (g-C3N4) based enrichment method of intact sialoglycopeptides (SGs) was developed. The intact SGs could be simply enriched and separated from protein tryptic digests by hydrogen bonding without damage of glycan structures due to the specific structure of g-C3N4. By optimizing the enrichment and elution conditions, 45 and 38 of SGs were detected from the tryptic digests of bovine fetuin and transferrin, respectively...
June 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28561948/identification-of-fucosylated-fetuin-a-as-a-potential-biomarker-for-cholangiocarcinoma
#6
Lucy Betesh, Mary Ann Comunale, Mengjun Wang, Hongyan Liang, Julie Hafner, Aykan Karabudak, Nasra H Giama, Catherine D Moser, Eiji Miyoshi, Lewis R Roberts, Timothy M Block, Anand Mehta
CLINICAL RELEVANCE: Cholangiocarcinoma is a cancer of bile duct cells for which no effective biomarker exists. Tumor masses are often not identifiable by imaging modalities as a result of the location of the tumor in the hilum of the liver or within the bile ducts. Because of the problems with obtaining a definitive tissue diagnosis, treatment and management decisions for patients with biliary strictures that may be malignant are difficult. The work presented here highlights the potential role of fucosylated fetuin-A as a biomarker of cholangiocarcinoma and may help in the early detection of this deadly cancer...
May 31, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28554965/fetuin-a-aggravates-lipotoxicity-in-podocytes-via-interleukin-1-signaling
#7
Jana M Orellana, Kapil Kampe, Friederike Schulze, Jonas Sieber, Andreas W Jehle
Sterile inflammation is considered critical in the pathogenesis of diabetic nephropathy (DN). Here we show that Fetuin-A (FetA) or lipopolysaccharide (LPS) exacerbate palmitic acid-induced podocyte death, which is associated with a strong induction of monocyte chemoattractant protein-1 (MCP-1) and keratinocyte chemoattractant (KC). Moreover, blockage of TLR4 prevents MCP-1 and KC secretion and attenuates podocyte death induced by palmitic acid alone or combined with FetA. In addition, inhibition of interleukin-1 (IL-1) signaling by anakinra, a recombinant human IL-1Ra, or a murinized anti-IL-1β antibody attenuates the inflammatory and ultimate cell death response elicited by FetA alone or combined with palmitic acid...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28551118/synthesis-of-hydrazide-functionalized-hydrophilic-polymer-hybrid-graphene-oxide-for-highly-efficient-n-glycopeptide-enrichment-and-identification-by-mass-spectrometry
#8
Haihong Bai, Yiting Pan, Cong Guo, Xinyuan Zhao, Bingquan Shen, Xinghe Wang, Zeyuan Liu, Yuanguo Cheng, Weijie Qin, Xiaohong Qian
Protein N-glycosylation is one of the most important post-translational modifications, participating in many key biological and pathological processes. Large-scale and precise identification of N-glycosylated proteins and peptides is especially beneficial for understanding their biological functions and for discovery of new clinical biomarkers and therapeutic drug targets. However, protein N-glycosylation is microheterogeneous and low abundant in living organisms, therefore specific enrichment of N-glycosylated proteins/peptides before mass spectrometry analysis is a prerequisite...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28536464/the-protective-effect-of-human-renal-sinus-fat-on-glomerular-cells-is-reversed-by-the-hepatokine-fetuin-a
#9
R Wagner, J Machann, M Guthoff, P P Nawroth, S Nadalin, M A Saleem, N Heyne, A Königsrainer, F Fend, F Schick, A Fritsche, N Stefan, H-U Häring, E Schleicher, D I Siegel-Axel
Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF. To study effects of the crosstalk between fetuin-A, RSF and kidney, human renal sinus fat cells (RSFC) were isolated and cocultured with human endothelial cells (EC) or podocytes (PO). RSFC caused downregulation of proinflammatory and upregulation of regenerative factors in cocultured EC and PO, indicating a protective influence of RFSC...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28535451/a-novel-carbohydrate-labeling-method-utilizing-transfer-hydrogenation-mediated-reductive-amination
#10
Zsuzsanna Kovács, Gábor Papp, Henrietta Horváth, Ferenc Joó, András Guttman
One of the most frequently used high-resolution glycan analysis methods in the biopharmaceutical and biomedical fields is capillary electrophoresis with laser-induced fluorescence (CE-LIF) detection. Glycans are usually labeled by reductive amination with a charged fluorophore containing a primary amine, which reacts with the aldehyde group at the reducing end of the glycan structures. In this reaction, first a Schiff base is formed that is reduced to form a stable conjugate by a hydrogenation reagent, such as sodium cyanoborohydride...
May 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28529199/can-fetuin-a-be-a-marker-for-insulin-resistance-and-poor-glycemic-control-in-children-with-type-1-diabetes-mellitus
#11
Ülkü Gül Sıraz, Murat Doğan, Nihal Hatipoğlu, Sabahttin Muhtaroğlu, Selim Kurtoğlu
OBJECTIVE: Backgroud Metabolic impairment in Type 1 Diabetes Mellitus (DM) with poor glycemic control causes insulin resistance, Non-Alcoholic Fatty Liver Disease (NAFLD) and atherosclerosis; thus, increased Carotid-intima media thickness (CIMT). The Fetuin-A has protective effect in cardiovascular disorders, which is increased in hepatosteatosis. We aimed to investigate reliability of Fetuin-A levels in early detection of diabetic complications in children with T1DM and to identify a cut-off value that may show poor metabolic control...
May 22, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28505081/isolation-of-rice-bran-lectins-and-characterization-of-their-unique-behavior-in-caco-2-cells
#12
Hajime Nakata, Ching Yu Lin, Maryam Abolhassani, Tomohisa Ogawa, Hiroaki Tateno, Jun Hirabayashi, Koji Muramoto
Rice bran lectins, named as RBA1 and RBA2, were isolated from Oryza sativa in two chromatography steps: affinity chromatography and cation-exchange chromatography. RBA1 was found to be composed of a covalently linked heterodimer of 20- and 12-kDa subunits, and RBA2 was a noncovalently linked dimer of 12-kDa subunits. Both RBA1 and RBA2 bound to desialylated complex glycoproteins such as fetuin, α1-acid glycoprotein, and transferrin, and agalactosylated complex glycoproteins such as agalacto fetuin, agalacto-α1-acid glycoprotein, and agalacto-transferrin, in addition to chitooligosacchrides...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28502901/neuraminidase-activity-of-blue-eye-disease-porcine-rubulavirus-specificity-affinity-and-inhibition-studies
#13
Gerardo Santos-López, María T Borraz-Argüello, Luis Márquez-Domínguez, Juan Carlos Flores-Alonso, Humberto Ramírez-Mendoza, Bernard Priem, Sébastien Fort, Verónica Vallejo-Ruiz, Julio Reyes-Leyva, Irma Herrera-Camacho
Porcine rubulavirus (PorPV), also known as La Piedad Michoacan Virus (LPMV) causes encephalitis and reproductive failure in newborn and adult pigs, respectively. The hemagglutinin-neuraminidase (HN) glycoprotein is the most exposed and antigenic of the virus proteins. HN plays central roles in PorPV infection; i.e., it recognizes sialic acid-containing cell receptors that mediate virus attachment and penetration; in addition, its neuraminidase (sialic acid releasing) activity has been proposed as a virulence factor...
May 6, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28500919/kinetics-of-circulating-fetuin-a-may-predict-mortality-independently-from-adiponectin-high-molecular-weight-adiponectin-and-prognostic-factors-in-critically-ill-patients-with-sepsis-a-prospective-study
#14
Irene Karampela, Evangelia Kandri, Georgios Antonakos, Evangelos Vogiatzakis, Gerasimos Socrates Christodoulatos, Athina Nikolaidou, George Dimopoulos, Apostolos Armaganidis, Maria Dalamaga
PURPOSE: Fetuin-A and adiponectin, major hepatokine and adipokine respectively, have been implicated in systematic inflammation. Our aim was to jointly investigate whether kinetics of circulating fetuin-A, adiponectin and its isoform HMWA predict 28-day mortality in sepsis. MATERIALS AND METHODS: In a prospective study, serum fetuin-A, adiponectin and HMWA were determined in 102 ICU patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age and gender...
May 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28491059/elucidation-of-the-role-of-3-hydroxy-fatty-acids-in-cryptococcus-amoeba-interactions
#15
Uju L Madu, Adepemi O Ogundeji, Carolina H Pohl, Jacobus Albertyn, Olihile M Sebolai
We previously reported that 3-hydroxy fatty acids promoted the survival of cryptococcal cells when acted upon by amoebae. To expand on this, the current study sought to explain how these molecules may protect cells. Our data suggest that 3-hydroxy fatty acids may subvert the internalization of cryptococcal cells via suppression of the levels of a fetuin A-like amoebal protein, which may be important for enhancing phagocytosis. Additionally, we show that an acapsular strain (that is devoid of 3-hydroxy fatty acids) was protected against the effects of hydrogen peroxide when exogenous 3-hydroxy fatty acids were present, but not in the absence of 3-hydroxy fatty acids...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28472687/purification-characterization-and-biological-significance-of-mannose-binding-lectin-from-dioscorea-bulbifera-bulbils
#16
Mamta Sharma, Vishwanathreddy Hotpet, Sindhura B R, Kamalanathan A S, Bale M Swamy, Shashikala R Inamdar
Dioscorea bulbifera or air potato has been used as a folk remedy to treat cancer. A mannose binding lectin from bulbils of D. bulbifera was purified in a single step by affinity chromatography on mucin coupled Sepharose 4B column, determined by its fine sugar specificity by glycan array analysis and studied for its clinical potential in cancer and HIV research. SDS-PAGE showed that lectin is a monomer of Mr 24kDa. DBL agglutinated only rabbit erythrocytes and was inhibited by mucin, asialomucin, fetuin, asialofetuin and transferrin but not by any monosaccharides...
May 1, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28469399/a-novel-biomarker-panel-to-identify-steroid-resistance-in-childhood-idiopathic-nephrotic-syndrome
#17
Michael R Bennett, LaTawnya Pleasant, Christopher Haffner, Qing Ma, Wendy D Haffey, Jun Ying, Michael Wagner, Kenneth D Greis, Prasad Devarajan
Idiopathic nephrotic syndrome (NS) is the most common glomerular disorder of childhood. Response to initial treatment with corticosteroids is an indicator of prognosis, as resistant patients often present more progressive disease. In this cross-sectional pilot study, we set out to discover a panel of noninvasive biomarkers that could distinguish steroid-resistant nephrotic syndrome (SRNS) from steroid-sensitive nephrotic syndrome (SSNS). Information gleaned from such a panel could yield more individualized treatment plans and prevent unnecessary steroid exposure in patients unlikely to respond...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28457217/the-role-of-fetuin-a-and-electrolytes-in-the-etiology-of-sialolithiasis
#18
Hasan Demirhan, Muhammet Yıldız, Özlem Önerci Çelebi, Şehide Baz, Berrin Berçik İnal, Özgür Yiğit
Objective The aim of this study was to investigate serum and saliva fetuin-A, protein, and electrolyte levels in patients with sialolithiasis. Study Design Prospective randomized controlled study. Setting Tertiary center. Subjects and Methods Twenty patients with recurrent sialadenitis secondary to submandibular salivary gland stones and 20 asymptomatic healthy volunteers without salivary gland stones were included in the study. Bimanual palpation and ultrasonography were performed in the patient and control groups...
May 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28452126/plasma-proteome-of-buffaloes
#19
Leticia Gomes de Pontes, Nayara Rodrigues Vieira Cavassan, Luciana Curtolo de Barros, Rui Seabra Ferreira Junior, Benedito Barraviera, Lucilene Delazari Dos Santos
The proteomic approach has aroused the interest of veterinary medicine researchers, especially regarding the production of biopharmaceuticals and diagnosis of diseases in farm animals. Water buffaloes have gained prominence in the world economy due to the quality of their milk, meat and leather, in addition to being an important donor of blood components. This work aimed to identify and characterize the proteins present in the blood plasma of Murrah buffaloes (Bubalus bubalis) through 2D-electrophoresis, in gel protein digestion followed by mass spectrometry technique and for albumin depletion, in solution protein digestion followed by shotgun analysis...
April 28, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28444098/the-cerebrospinal-fluid-in-multiple-sclerosis-far-beyond-the-bands
#20
Renan Barros Domingues, Gustavo Bruniera Peres Fernandes, Fernando Brunale Vilela de Moura Leite, Charles Peter Tilbery, Rodrigo Barbosa Thomaz, Gisele Sampaio Silva, Cristóvão Luis Pitangueira Mangueira, Carlos Augusto Senne Soares
The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers have emerged in the context of multiple sclerosis. The search for new biomarkers reflect the need of a better evaluation of disease activity, disease progression, and treatment efficiency...
January 2017: Einstein
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