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https://www.readbyqxmd.com/read/28346398/sirtuin-1-sirt1-overexpression-in-baf3-cells-contributes-to-cell-proliferation-promotion-apoptosis-resistance-and-pro-inflammatory-cytokine-production
#1
Qian Wang, Chao Yan, Miaomiao Xin, Li Han, Yunqing Zhang, Mingshu Sun
BACKGROUND B lymphocyte hyperactivity is a main characteristic of systemic lupus erythematosus (SLE), and B lymphocytes play a prominent pathogenic role in the development and progression of SLE. The aim of this study was to investigate the role of Sirtuin 1 (Sirt1) in B lymphocytes. MATERIAL AND METHODS Mouse B lymphocytes BaF3 was transfected with Sirt1 vector or shRNA against Sirt1. Then the transfected cells viability and apoptosis were respectively determined by MTT assay and flow cytometry. In addition, the mRNA levels of three pro-inflammatory cytokines and p53 were detected by RT-PCR...
March 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28345779/sacral-neuromodulation-for-detrusor-hyperactivity-with-impaired-contractility
#2
Derek B Hennessey, Nathan Hoag, Johan Gani
INTRODUCTION: Detrusor hyperactivity with impaired contractility (DHIC) is a challenging condition to manage. Sacral neuromodulation (SNM) is a proven treatment modality for both the individual aspects of DHIC. To date, data reporting the outcome of SNM for DHIC are lacking. MATERIALS AND METHODS: Consecutive patients undergoing SNM for DHIC were followed prospectively, from April 2013 to October 2016. Patient demographics, bladder diaries, subjective response rates, ICIQ-OAB, and PGI-I scores were recorded...
March 27, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28345734/-restless-legs-syndrome-in-patients-diagnosed-with-attention-deficit-hyperactivity-disorder
#3
C Castano-De la Mota, N Moreno-Acero, R Losada-Del Pozo, V Soto-Insuga, A Perez-Villena, C Rodriguez-Fernandez, F Martin-Del Valle, M Pons-Rodriguez
INTRODUCTION: Restless legs syndrome (RLS) is a common neurological disease. RLS has been linked to various psychiatric disorders, especially with attention deficit hyperactivity disorder (ADHD). AIMS: The main objective was to describe the frequency of RLS in pediatric patients diagnosed with ADHD. Secondary objectives of the study were describe other sleep disorders in ADHD patients. PATIENTS AND METHODS: A multicentre prospective study was conducted in nine Spanish centers...
April 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28345402/clinical-and-functional-correlates-of-processing-speed-in-pediatric-attention-deficit-hyperactivity-disorder-a-systematic-review-and-meta-analysis
#4
Nathan E Cook, Ellen B Braaten, Craig B H Surman
It is well established that processing speed is negatively impacted in children and adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD). Unfortunately, exactly how processing speed vulnerabilities manifest in daily functioning has not been well established. To support clinical care of youth with ADHD, it is important to better understand the functional consequences and relevant outcomes associated with processing speed deficits. This systematic review and meta-analysis sought to identify the association between processing speed and clinical or functional correlates among children or adolescents diagnosed with ADHD...
March 27, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28345387/multimodal-treatment-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-6-month-follow-up
#5
Nezla S Duric, Jørg Assmus, Doris Gundersen, Alisa Duric Golos, Irene B Elgen
BACKGROUND: Different treatment approaches aimed at reducing attention-deficit/hyperactivity disorder (ADHD) core symptoms are available. However, factors such as intolerance, side-effects, lack of efficacy, high new technology costs, and placebo effect have spurred on an increasing interest in alternative or complementary treatment. AIM: The aim of this study is to explore efficacy of multimodal treatment consisting of standard stimulant medication (methylphenidate) and neurofeedback (NF) in combination, and to compare it with the single treatment in 6-month follow-up in ADHD children and adolescents...
March 27, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28344653/characterization-of-a-de-novo-ssmc-17-detected-in-a-girl-with-developmental-delay-and-dysmorphic-features
#6
Lana Stavber, Sara Bertok, Jernej Kovač, Marija Volk, Luca Lovrečić, Tadej Battelino, Tinka Hovnik
BACKGROUND: The majority of small supernumerary marker chromosome cases arise de novo and their frequency in newborns is 0.04%. We report on a girl with developmental delay and dysmorphic features with a non-mosaic de novo sSMC that originated from the pericentric region of q arm in chromosome 17. CASE PRESENTATION: The girl presented with developmental delay, speech delay, myopia, mild muscle hypotonia, hypoplasia of orbicular muscle, poor concentration, and hyperactivity...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/28344567/does-hunger-contribute-to-socioeconomic-gradients-in-behavior
#7
Daniel Nettle
Recent research has uncovered many examples of socioeconomic gradients in behavior and psychological states. As yet there is no theoretical consensus on the nature of the causal processes that produce these gradients. Here, I present the hunger hypothesis, namely the claim that part of the reason that people of lower socioeconomic position behave and feel as they do is that they are relatively often hungry. The hunger hypothesis applies in particular to impulsivity-hyperactivity, irritability-aggression, anxiety, and persistent narcotic use, all of which have been found to show socioeconomic gradients...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28343454/adhd-patients-fail-to-maintain-task-goals-in-face-of-subliminally-and-consciously-induced-cognitive-conflicts
#8
K Gohil, A Bluschke, V Roessner, A-K Stock, C Beste
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) patients have been reported to display deficits in action control processes. While it is known that subliminally and consciously induced conflicts interact and conjointly modulate action control in healthy subjects, this has never been investigated for ADHD. METHOD: We investigated the (potential) interaction of subliminally and consciously triggered response conflicts in children with ADHD and matched healthy controls using neuropsychological methods (event-related potentials; ERPs) to identify the involved cognitive sub-processes...
March 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28342214/real-time-fmri-neurofeedback-in-adolescents-with-attention-deficit-hyperactivity-disorder
#9
Analucia A Alegria, Melanie Wulff, Helen Brinson, Gareth J Barker, Luke J Norman, Daniel Brandeis, Daniel Stahl, Anthony S David, Eric Taylor, Vincent Giampietro, Katya Rubia
Attention Deficit Hyperactivity Disorder (ADHD) is associated with poor self-control, underpinned by inferior fronto-striatal deficits. Real-time functional magnetic resonance neurofeedback (rtfMRI-NF) allows participants to gain self-control over dysregulated brain regions. Despite evidence for beneficial effects of electrophysiological-NF on ADHD symptoms, no study has applied the spatially superior rtfMRI-NF neurotherapy to ADHD. A randomized controlled trial tested the efficacy of rtfMRI-NF of right inferior prefrontal cortex (rIFG), a key region that is compromised in ADHD and upregulated with psychostimulants, on improvement of ADHD symptoms, cognition, and inhibitory fMRI activation...
March 25, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28341729/vitamin-d-deficiency-and-diabetes
#10
REVIEW
Michael J Berridge
Vitamin D deficiency has been linked to the onset of diabetes. This review summarizes the role of Vitamin D in maintaining the normal release of insulin by the pancreatic beta cells (β-cells). Diabetes is initiated by the onset of insulin resistance. The β-cells can overcome this resistance by releasing more insulin, thus preventing hyperglycaemia. However, as this hyperactivity increases, the β-cells experience excessive Ca(2+) and reactive oxygen species (ROS) signalling that results in cell death and the onset of diabetes...
March 24, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28341321/reprint-of-repeated-adolescent-activity-based-anorexia-influences-central-estrogen-signaling-and-adulthood-anxiety-like-behaviors-in-rats
#11
Tien-Jui Lee, Kimberly P Kinzig
Anorexia nervosa (AN) typically presents in adolescence and is highly comorbid with anxiety and depression, which often persist after elimination of AN symptomology. The activity-based anorexia (ABA) paradigm allows for evaluation of behavioral and neuroendocrine consequences of AN-like behaviors, including voluntary anorexia, hyperactivity, and disruption of the hypothalamic-pituitary-gonadal (HPG) and the hypothalamic pituitary adrenal (HPA) axis. Because ABA in adolescent females results in increased anxiety-like behavior in adulthood and the estrogen signaling system has been shown to play a role in anxiety and food intake, we investigated the role of ovarian hormones in adolescent ABA-treated rats, and long-term effects of mid- and late adolescent ABA exposure on behavior and estrogen signaling...
March 21, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28341090/transient-isolated-lower-bulbar-palsy-with-elevated-serum-anti-gm1-and-anti-gd1b-antibodies-during-aripiprazole-treatment
#12
Tae Hwan Han, Do Yeon Kim, Dong Woo Park, Jin-Hwa Moon
BACKGROUND: Transient bulbar palsy without involvement of the facial or extraocular muscles is a rare presentation. It is considered a form of cranial polyneuropathy, a variant of Guillain-Barré syndrome that is related to the autoimmune mechanisms induced by preceding infections or vaccinations. However, drug-induced cranial polyneuropathy has not previously been reported. We describe a boy with isolated bulbar palsy and positive serum antiganglioside antibodies during aripiprazole treatment...
January 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28339895/does-parental-health-mediate-the-relationship-between-parental-uninsurance-and-insured-children-s-health-outcomes-evidence-from-a-u-s-national-survey
#13
Ilhom Akobirshoev, Diana Bowser, Susan L Parish, Cindy Thomas, Sara S Bachman
Although the United States has made great strides in ensuring near universal health care access for children, the health insurance coverage gap between children and their parents remains high. This study analyzed aggregated data from the 2006-2013 National Health Interview Survey to investigate the direct relationships between parental uninsurance and children's health outcomes. Authors explored how parental health mediates the relationship between parents' health and children's health outcomes. Results suggest that insured children of uninsured parents have worse health status and are at higher risk of asthma, attention-deficit/hyperactivity disorder, developmental delays, learning disabilities, and mental disabilities compared with insured children of insured parents...
March 2, 2017: Health & Social Work
https://www.readbyqxmd.com/read/28339635/the-impact-of-zonisamide-on-the-development-and-course-of-alcohol-dependence-in-rabbits-a-pharmaco-eeg-study
#14
Agata Krupa-Burtnik, Ewa Zwierzynska, Anna Kordala, Boguslawa Pietrzak
Aims: Zonisamide is a new anti-epileptic drug whose mechanism of action is associated with neurotransmission systems also involved in the pathogenesis of addiction. Recently, the role of memory processes and the hippocampus (Hp) is underlined in dependence. In our previous study, we determined that zonisamide decreases changes in hippocampal bioelectric activity induced by a single dose of ethanol. Methods: This study uses a pharmaco-EEG method to examine the impact of zonisamide on the development and course of alcohol dependence in rabbits...
February 17, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28339495/microrna-expression-profiles-identify-disease-specific-alterations-in-systemic-lupus-erythematosus-and-primary-sj%C3%A3-gren-s-syndrome
#15
Ji-Qing Chen, Gábor Papp, Szilárd Póliska, Krisztina Szabó, Tünde Tarr, Bálint László Bálint, Péter Szodoray, Margit Zeher
The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological disturbances in autoimmune diseases...
2017: PloS One
https://www.readbyqxmd.com/read/28339122/mortality-risk-in-a-nationwide-cohort-of-individuals-with-tic-disorders-and-with-tourette-syndrome
#16
Sandra M Meier, Søren Dalsgaard, Preben B Mortensen, James F Leckman, Kerstin J Plessen
BACKGROUND: Few studies have investigated mortality risk in individuals with tic disorders. METHODS: We thus measured the risk of premature death in individuals with tic disorders and with Tourette syndrome in a prospective cohort study with 80 million person-years of follow-up. We estimated mortality rate ratios and adjusted for calendar year, age, sex, urbanicity, maternal and paternal age, and psychiatric disorders to compare individuals with and without tic disorders...
March 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28338919/genetic-overlap-between-schizophrenia-and-developmental-psychopathology-longitudinal-and-multivariate-polygenic-risk-prediction-of-common-psychiatric-traits-during-development
#17
Michel G Nivard, Suzanne H Gage, Jouke J Hottenga, Catharina E M van Beijsterveldt, Abdel Abdellaoui, Meike Bartels, Bart M L Baselmans, Lannie Ligthart, Beate St Pourcain, Dorret I Boomsma, Marcus R Munafò, Christel M Middeldorp
BACKGROUND: Several nonpsychotic psychiatric disorders in childhood and adolescence can precede the onset of schizophrenia, but the etiology of this relationship remains unclear. We investigated to what extent the association between schizophrenia and psychiatric disorders in childhood is explained by correlated genetic risk factors. METHODS: Polygenic risk scores (PRS), reflecting an individual's genetic risk for schizophrenia, were constructed for 2588 children from the Netherlands Twin Register (NTR) and 6127 from the Avon Longitudinal Study of Parents And Children (ALSPAC)...
March 11, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28337802/the-snf1-activating-kinase-sak1-is-a-key-regulator-of-metabolic-adaptation-and-in-vivo-fitness-of-candida-albicans
#18
Bernardo Ramírez-Zavala, Austin Mottola, Julia Haubenreißer, Sabrina Schneider, Stefanie Allert, Sascha Brunke, Knut Ohlsen, Bernhard Hube, Joachim Morschhäuser
The metabolic flexibility of the opportunistic fungal pathogen Candida albicans is important for colonisation and infection of different host niches. Complex regulatory networks, in which protein kinases play central roles, link metabolism and other virulence-associated traits, such as filamentous growth and stress resistance, and thereby control commensalism and pathogenicity. By screening a protein kinase deletion mutant library that was generated in the present work using an improved SAT1 flipper cassette, we found that the previously uncharacterised kinase Sak1 is a key upstream activator of the protein kinase Snf1, a highly conserved regulator of nutrient stress responses that is essential for viability in C...
March 23, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28337734/diffusion-tensor-imaging-dti-findings-in-adult-civilian-military-and-sport-related-mild-traumatic-brain-injury-mtbi-a-systematic-critical-review
#19
Breton Michael Asken, Steven T DeKosky, James R Clugston, Michael S Jaffee, Russell M Bauer
This review seeks to summarize diffusion tensor imaging (DTI) studies that have evaluated structural changes attributed to the mechanisms of mild traumatic brain injury (mTBI) in adult civilian, military, and athlete populations. Articles from 2002 to 2016 were retrieved from PubMed/MEDLINE, EBSCOhost, and Google Scholar, using a Boolean search string containing the following terms: "diffusion tensor imaging", "diffusion imaging", "DTI", "white matter", "concussion", "mild traumatic brain injury", "mTBI", "traumatic brain injury", and "TBI"...
March 24, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28336561/mice-lacking-the-inhibitory-collagen-receptor-lair-1-exhibit-a-mild-thrombocytosis-and-hyperactive-platelets
#20
Christopher W Smith, Steven G Thomas, Zaher Raslan, Pushpa Patel, Maxwell Byrne, Marie Lordkipanidzé, Danai Bem, Linde Meyaard, Yotis A Senis, Steve P Watson, Alexandra Mazharian
OBJECTIVE: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a collagen receptor that belongs to the inhibitory immunoreceptor tyrosine-based inhibition motif-containing receptor family. It is an inhibitor of signaling via the immunoreceptor tyrosine-based activation motif-containing collagen receptor complex, glycoprotein VI-FcRγ-chain. It is expressed on hematopoietic cells, including immature megakaryocytes, but is not detectable on platelets. Although the inhibitory function of LAIR-1 has been described in leukocytes, its physiological role in megakaryocytes and in particular in platelet formation has not been explored...
March 23, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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