keyword
https://read.qxmd.com/read/38536951/attention-deficit-hyperactivity-disorder-in-children-ages-5-17-years-united-states-2020-2022
#1
JOURNAL ARTICLE
Cynthia Reuben, Nazik Elgaddal
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common mental disorders of childhood (1). It is characterized by a pattern of inattention, impulsivity, or hyperactivity that leads to functional impairment experienced in multiple settings (2). Symptoms of ADHD occur during childhood, and many children continue to have symptoms and impairment through adolescence and into adulthood (3). This report describes the percentage of children and adolescents ages 5-17 years who had ever been diagnosed with ADHD from the 2020-2022 National Health Interview Survey (NHIS)...
March 2024: NCHS Data Brief
https://read.qxmd.com/read/38536491/no-evidence-for-a-causal-contribution-of-bioavailable-testosterone-to-adhd-in-sex-combined-and-sex-specific-two-sample-mendelian-randomization-studies
#2
JOURNAL ARTICLE
Lars Dinkelbach, Triinu Peters, Corinna Grasemann, Johannes Hebebrand, Anke Hinney, Raphael Hirtz
The higher prevalence of attention-deficit/hyperactivity disorder (ADHD) in males raises the question of whether testosterone is implicated in ADHD risk. However, cross-sectional studies did not identify an association between ADHD and testosterone levels. Mendelian randomization (MR) studies can overcome limitations inherent to association studies, especially of reverse causation and residual confounding. In the current study, sex-combined and sex-specific two-sample MR analyses were conducted to address whether testosterone has a causal influence on ADHD risk...
March 27, 2024: European Child & Adolescent Psychiatry
https://read.qxmd.com/read/38536448/arterial-spin-labelling-magnetic-resonance-imaging-and-perfusion-patterns-in-neurocognitive-and-other-mental-disorders-a-systematic-review
#3
REVIEW
Rita Ferreira, António J Bastos-Leite
We reviewed 33 original research studies assessing brain perfusion, using consensus guidelines from a "white paper" issued by the International Society for Magnetic Resonance in Medicine Perfusion Study Group and the European Cooperation in Science and Technology Action BM1103 ("Arterial Spin Labelling Initiative in Dementia"; https://www.cost.eu/actions/BM1103/ ). The studies were published between 2011 and 2023 and included participants with subjective cognitive decline plus; neurocognitive disorders, including mild cognitive impairment (MCI), Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), dementia with Lewy bodies (DLB) and vascular cognitive impairment (VCI); as well as schizophrenia spectrum disorders, bipolar and major depressive disorders, autism spectrum disorder, attention-deficit/hyperactivity disorder, panic disorder and alcohol use disorder...
March 27, 2024: Neuroradiology
https://read.qxmd.com/read/38536438/-parental-strain-inattention-hyperactivity-symptoms-and-parent-reported-adhd-in-children-and-adolescents-results-of-the-kiggs-study
#4
JOURNAL ARTICLE
Laura Neuperdt, Ann-Kristin Beyer, Stephan Junker, Elvira Mauz, Heike Hölling, Robert Schlack
BACKGROUND: A child's attention deficit hyperactivity disorder (ADHD) is associated with strain for the parents. In turn, psychosocial parental strain is associated with higher probabilities for the occurrence of inattention/hyperactivity symptoms (IHS) in their children. The aim of this paper is to assess the association between parental strain, IHS, and a parent-reported ADHD diagnosis of the children. METHODOLOGY: Based on data from n = 4596 participants of the KiGGS cohort (wave 2: 2014-2017), the type and extent of parental strain was set in relation to IHS and an ADHD diagnosis of the child in cross-sectional analysis...
March 27, 2024: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://read.qxmd.com/read/38534873/adhd-aid-aiding-tool-for-detecting-children-s-attention-deficit-hyperactivity-disorder-via-eeg-based-multi-resolution-analysis-and-feature-selection
#5
JOURNAL ARTICLE
Omneya Attallah
The severe effects of attention deficit hyperactivity disorder (ADHD) among adolescents can be prevented by timely identification and prompt therapeutic intervention. Traditional diagnostic techniques are complicated and time-consuming because they are subjective-based assessments. Machine learning (ML) techniques can automate this process and prevent the limitations of manual evaluation. However, most of the ML-based models extract few features from a single domain. Furthermore, most ML-based studies have not examined the most effective electrode placement on the skull, which affects the identification process, while others have not employed feature selection approaches to reduce the feature space dimension and consequently the complexity of the training models...
March 20, 2024: Biomimetics
https://read.qxmd.com/read/38534804/cannabis-use-and-its-impact-on-mental-health-in-youth-in-australia-and-the-united-states-a-scoping-review
#6
REVIEW
Aayush Baral, Fahad Hanna, Ritesh Chimoriya, Kritika Rana
Cannabis is a widely used substance among the youth population, with an estimated 2.8% currently smoking cannabis. Its popularity is growing due to the perception of its harmless nature and lack of dependence. However, this increase in use has been linked to mental health issues, especially since its partial decriminalisation in some part of the United States and Australia. The objective of this scoping review was to investigate the mental health impact of cannabis use among young people in Australia and the United States...
February 29, 2024: Epidemiologia (Basel)
https://read.qxmd.com/read/38534343/the-exon-junction-complex-factor-rbm8a-in-glial-fibrillary-acid-protein-expressing-astrocytes-modulates-locomotion-behaviors
#7
JOURNAL ARTICLE
Shravan Asthana, Jennifer Mott, Mabel Tong, Zifei Pei, Yingwei Mao
The role of RNA Binding Motif Protein 8a (RBM8A), an exon junction complex (EJC) component, in neurodevelopmental disorders has been increasingly studied for its crucial role in regulating multiple levels of gene expression. It regulates mRNA splicing, translation, and mRNA degradation and influences embryonic development. RBM8A protein is expressed in both neurons and astrocytes, but little is known about RBM8A's specific role in glial fibrillary acid protein (GFAP)-positive astrocytes. To address the role of RBM8A in astrocytes, we generated a conditional heterozygous knockout (KO) mouse line of Rbm8a in astrocytes using a GFAP-cre line...
March 13, 2024: Cells
https://read.qxmd.com/read/38534337/phosphorylations-and-acetylations-of-cytochrome-c-control-mitochondrial-respiration-mitochondrial-membrane-potential-energy-ros-and-apoptosis
#8
REVIEW
Paul T Morse, Tasnim Arroum, Junmei Wan, Lucynda Pham, Asmita Vaishnav, Jamie Bell, Lauren Pavelich, Moh H Malek, Thomas H Sanderson, Brian F P Edwards, Maik Hüttemann
Cytochrome c (Cyt c ) has both life-sustaining and cellular death-related functions, depending on subcellular localization. Within mitochondria, Cyt c acts as a single electron carrier as part of the electron transport chain (ETC). When released into the cytosol after cellular insult, Cyt c triggers the assembly of the apoptosome, committing the cell to intrinsic apoptosis. Due to these dual natures, Cyt c requires strong regulation by the cell, including post-translational modifications, such as phosphorylation and acetylation...
March 12, 2024: Cells
https://read.qxmd.com/read/38534136/coming-to-terms-with-our-racecar-brains-academic-mothers-experiencing-adult-diagnosis-of-adhd
#9
JOURNAL ARTICLE
Emily T Cripe, Sarah Symonds LeBlanc, Meike Eilert, Kimberly Bernhardt
This collaborative autoethnography explores the experiences of women academics and mothers who received late diagnoses of Attention Deficit Hyperactivity Disorder (ADHD). Due to the historical underdiagnosis of women, little research has focused on this specific demographic. We shed light on how ADHD presents in women, interweaving our stories with extant literature and emphasizing the need to understand this demographic's experiences better. This piece discusses our process of seeking diagnosis and treatment, the communicative disenfranchisement we faced, and the stigma associated with ADHD...
March 27, 2024: Health Communication
https://read.qxmd.com/read/38533143/propofol-sedation-in-pediatric-upper-endoscopy-a-study-of-pharmacodynamics-and-the-effects-of-gastroenterologists-anesthesiologists-and-supervised-participants-on-the-procedure-time-and-sedation-time
#10
JOURNAL ARTICLE
Ahila Manivannan, Shailender Madani, Michael Woodall, George McKelvey, Sharon Kemper
Background and aims Propofol combined with fentanyl is a commonly used sedative for pediatric upper endoscopies (UEs). The primary aim was to study the association between propofol dose and procedure and sedation time. The secondary aims were to assess the pharmacodynamics of propofol use with fentanyl and evaluate if gastroenterologists' and anesthesiologists' years of experience or the presence of supervised participants (such as students, residents, and fellows) have any influence on the procedure and sedation time...
February 2024: Curēus
https://read.qxmd.com/read/38532986/a-theory-of-the-neural-mechanisms-underlying-negative-cognitive-bias-in-major-depression
#11
JOURNAL ARTICLE
Yuyue Jiang
The widely acknowledged cognitive theory of depression, developed by Aaron Beck, focused on biased information processing that emphasizes the negative aspects of affective and conceptual information. Current attempts to discover the neurological mechanism underlying such cognitive and affective bias have successfully identified various brain regions associated with severally biased functions such as emotion, attention, rumination, and inhibition control. However, the neurobiological mechanisms of how individuals in depression develop this selective processing toward negative is still under question...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38532901/a-6-year-old-with-childhood-absence-epilepsy-and-motor-hyperactivity
#12
JOURNAL ARTICLE
Stéphane Auvin
A case study of a child with childhood absence epilepsy and hyperactivity introduces the discussion around the psychiatric diagnosis, differential considerations, and pharmacologic treatment options for ADHD/hyperactivity in children with epilepsy. Most of the time, ADHD in children with epilepsy is an inattentive form. The assessment emphasizes the need to differentiate ADHD symptoms from other psychiatric comorbidities. This is also crucial to evaluate when symptoms emerged, their impact on daily life, and if it could be a potential medication side effect...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38532736/prediction-of-internalizing-and-externalizing-symptoms-in-late-childhood-from-attention-deficit-hyperactivity-disorder-symptoms-in-early-childhood
#13
JOURNAL ARTICLE
Agnieszka Mlodnicka, Maxwell Mansolf, Aruna Chandran, Izzuddin M Aris, Catrina A Calub, Shaikh Ahmad, Allison Shapiro, David Cochran, Bibiana Restrepo, Rebecca Schmidt, Irva Hertz-Picciotto, Deborah Bennett, Diane R Gold, T Michael O'Shea, Leslie Leve, Julie B Schweitzer
Limited analyses based on national samples have assessed whether early attention-deficit/hyperactivity disorder (ADHD) symptoms predict later internalizing and externalizing symptoms in youth and the influence of sex and pubertal timing on subsequent psychiatric symptoms. This study analyzed data ( n = 2818) from the Environmental influences on Child Health Outcomes Program national cohort. Analyses used data from early childhood (mean age = 5.3 years) utilizing parent-reported ADHD symptoms to predict rates of internalizing and externalizing symptoms from late childhood/adolescence (mean age = 11...
March 27, 2024: Development and Psychopathology
https://read.qxmd.com/read/38532343/phenome-wide-causal-associations-between-osteoarthritis-and-other-complex-traits-through-the-latent-causal-variable-analysis
#14
JOURNAL ARTICLE
Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhihong Li
BACKGROUND: Individuals with osteoarthritis present with comorbidities, and the potential causal associations remain incompletely elucidated. The present study undertook a large-scale investigation about the causality between osteoarthritis and variable traits, using the summary-level data of genome-wide association studies (GWAS). METHODS: The present study included the summary-level GWS data of knee osteoarthritis, hip osteoarthritis, hip or knee osteoarthritis, hand osteoarthritis, and other 1355 traits...
March 26, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38532040/light-cannabis-use-and-the-adolescent-brain-an-8-years-longitudinal-assessment-of-mental-health-cognition-and-reward-processing
#15
JOURNAL ARTICLE
Inês Macedo, Tiago O Paiva, Rita Pasion, Laura Daedelow, Andreas Heinz, Ana Magalhães, Tobias Banaschewski, Arun L W Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Nathalie Holz, Juliane H Fröhner, Michael N Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Fernando Barbosa
RATIONALE: For decades, cannabis has been the most widely used illicit substance in the world, particularly among youth. Research suggests that mental health problems associated with cannabis use may result from its effect on reward brain circuit, emotional processes, and cognition. However, findings are mostly derived from correlational studies and inconsistent, particularly in adolescents. OBJECTIVES AND METHODS: Using data from the IMAGEN study, participants (non-users, persistent users, abstinent users) were classified according to their cannabis use at 19 and 22 years-old...
March 26, 2024: Psychopharmacology
https://read.qxmd.com/read/38531425/adolescent-activity-based-anorexia-has-a-substantial-and-prolonged-impact-on-social-behavior-in-young-adult-female-rats
#16
JOURNAL ARTICLE
Melinda Karth, Kimberly Kinzig
Activity-based anorexia (ABA) is a rodent model of anorexia nervosa (AN) that induces several key components of AN, including voluntary reduction in food intake, reduced body weight, hyperactivity, and alterations to the hypothalamic-pituitary-adrenal (HPA) axis. Previous research has demonstrated persistently increased anxiety-like behavior in the elevated plus maze (EPM), a test measuring avoidance of novel and open areas in adult female rats that experienced ABA during adolescence and are weight-restored in adulthood...
March 24, 2024: Physiology & Behavior
https://read.qxmd.com/read/38531021/neurodevelopmental-and-functional-outcomes-following-in-utero-exposure-to-antiseizure-medication-a-systematic-review
#17
JOURNAL ARTICLE
Eliza Honybun, Emily Cockle, Charles B Malpas, Terence J O'Brien, Frank J Vajda, Piero Perucca, Genevieve Rayner
BACKGROUND AND OBJECTIVES: To undertake a systematic review of the available literature to examine the relationship between prenatal antiseizure medication (ASM) exposure and adverse postnatal neurodevelopmental outcomes, focusing on social, emotional, behavioral, and adaptive domains of human function, and the frequency of neurodevelopmental and psychiatric disorders in ASM-exposed offspring. METHODS: Electronic searches of MEDLINE, PsychINFO, and EMBASE were conducted and limited to studies published between 1990 and 2023 in English...
April 23, 2024: Neurology
https://read.qxmd.com/read/38530314/transitional-neonatal-hypoglycemia-and-adverse-neurodevelopment-in-midchildhood
#18
JOURNAL ARTICLE
Marcia Roeper, Henrike Hoermann, Lisa M Körner, Marvin Sobottka, Ertan Mayatepek, Sebastian Kummer, Thomas Meissner
IMPORTANCE: The circumstances under which neonatal hypoglycemia leads to brain damage remain unclear due to a lack of long-term data on the neurodevelopment of affected children. As a result, diagnostic strategies and treatment recommendations are inconsistent. OBJECTIVE: To evaluate whether the occurrence of severe transitional neonatal hypoglycemia (defined as having at least 1 blood glucose measurement of 30 mg/dL or below) is associated with adverse neurodevelopment in midchildhood...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38530121/gray-matter-volume-associations-in-youth-with-adhd-features-of-inattention-and-hyperactivity-impulsivity
#19
JOURNAL ARTICLE
Gabrielle E Reimann, Hee Jung Jeong, E Leighton Durham, Camille Archer, Tyler M Moore, Fanual Berhe, Randolph M Dupont, Antonia N Kaczkurkin
BACKGROUND: Prior research has shown smaller cortical and subcortical gray matter volumes among individuals with attention-deficit/hyperactivity disorder (ADHD). However, neuroimaging studies often do not differentiate between inattention and hyperactivity/impulsivity, which are distinct core features of ADHD. The present study uses an approach to disentangle overlapping variance to examine the neurostructural heterogeneity of inattention and hyperactivity/impulsivity dimensions. METHODS: We analyzed data from 10,692 9- to 10-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38529904/diagnostic-assessment-of-autism-spectrum-disorder-in-transgender-and-gender-diverse-youth
#20
JOURNAL ARTICLE
Rachel K Greene, Tara M Rutter, Randi A Phelps, Emily K Olsen, Raquel Harmon, Danielle N Moyer
Objective: Higher prevalence of autism spectrum disorder (ASD) diagnosis and associated traits has been observed among transgender and gender diverse (TGD) youth, and the number of TGD youth requesting evaluation for autism is growing. This study explored the demographic and clinical profiles of TGD youth evaluated in a specialty autism clinic. Method: Retrospective autism evaluation results for 41 TGD youth aged 5-18 years and 67 cisgender-matched controls were included in the study. Results: Approximately, half of TGD youth were diagnosed with autism (TGDASD+; n  = 19 vs...
March 26, 2024: Clinical Neuropsychologist
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