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https://www.readbyqxmd.com/read/28107842/mentha-spicata-as-natural-analgesia-for-treatment-of-pain-in-osteoarthritis-patients
#1
REVIEW
Mohaddese Mahboubi
Osteoarthritis, as the major cause of chronic musculoskeletal pain, impacts people aged 45 and above. The first line analgesic treatments have reported minimal short term effects. The use of essential oils as pain killer has increased, recently. Mentha spicata, or spearmint essential oil is famous due to its anti-flatulence effects, but one less known biological activity of spearmint is its analgesic activity. The aim of our study was to confirm the analgesic effects of M. spicata essential oil. In this review, we evaluated the articles on analgesic activities of M...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28104696/systematic-characterization-of-human-testis-specific-actin-capping-protein-%C3%AE-3-as-a-possible-biomarker-for-male-infertility
#2
T Soda, Y Miyagawa, N Ueda, K Takezawa, H Okuda, S Fukuhara, K Fujita, H Kiuchi, M Uemura, Y Okamoto, A Tsujimura, H Tanaka, N Nonomura
STUDY QUESTION: Is actin capping protein (CP) β3 involved in human spermatogenesis and male infertility? SUMMARY ANSWER: Human CPβ3 (hCPβ3) is expressed in testis, changes its localization dynamically during spermatogenesis, and has some association with male infertility. WHAT IS KNOWN ALREADY: The testis-specific α subunit of CP (CPα3) was previously identified in human, and mutations in the cpα3 gene in mouse were shown to induce malformation of the sperm head and male infertility...
January 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28099657/quality-of-life-and-treatment-adherence-in-hypertensive-patients-systematic-review-with-meta-analysis
#3
Ana Célia Caetano de Souza, José Wicto Pereira Borges, Thereza Maria Magalhães Moreira
OBJECTIVE: To verify the effects of antihypertensive treatment (pharmacological and non-pharmacological) on the health-related quality of life of individuals with hypertension. METHODS: We conducted a systematic review with meta-analysis using the following databases: IBECS, LILACS, SciELO, Medline, Cochrane, Science Direct, Scopus and the Brazilian Capes Theses and Dissertations Database. The statistical analysis was performed using Review Manager, version 5.2...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28097909/administration-of-ketamine-for-unipolar-and-bipolar-depression
#4
Christoph Kraus, Ulrich Rabl, Thomas Vanicek, Laura Carlberg, Ana Popovic, Marie Spies, Lucie Bartova, Gregor Gryglewski, Konstantinos Papageorgiou, Rupert Lanzenberger, Matthäus Willeit, Dietmar Winkler, Janusz K Rybakowski, Siegfried Kasper
OBJECTIVE: Clinical trials demonstrated that ketamine exhibits rapid antidepressant efficacy when administered in subanaesthetic dosages. We reviewed currently available literature investigating efficacy, response rates and safety profile. METHODS: Twelve studies investigating unipolar, seven on bipolar depression were included after search in medline, scopus and web of science. RESULTS: Randomized, placebo-controlled or open-label trials reported antidepressant response rates after 24 h on primary outcome measures at 61%...
January 18, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28093828/a-systematic-review-on-ethnomedicines-of-anti-cancer-plants
#5
REVIEW
Akash Tariq, Sehrish Sadia, Kaiwen Pan, Ihteram Ullah, Sakina Mussarat, Feng Sun, Olatunji Olusanya Abiodun, Altanzagas Batbaatar, Zilong Li, Dagang Song, Qinli Xiong, Riaz Ullah, Suliman Khan, Buddha Bahadur Basnet, Brawin Kumar, Rabiul Islam, Muhammad Adnan
Cancer is a serious health problem and the second leading cause of death around the globe. Present review is an attempt to provide utmost information based on ethno-pharmacological and toxicological aspects of anti-cancer plants of the world. A total of 276 articles published in English journals and containing maximum ethnomedicinal information were reviewed using several data sources such as; Google scholar, Web of Science, Scopus, PubMed and floras of different countries. A total of 199 anti-cancer plants were recorded in present review and results indicated that traditional medicines are mostly being use in developing countries for cancer treatment...
January 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28090735/high-throughput-protein-targeted-biomolecular-detection-using-frequency-domain-faraday-rotation-spectroscopy
#6
Richard J Murdock, Shawn A Putnam, Soumen Das, Ankur Gupta, Elyse D Z Chase, Sudipta Seal
A clinically relevant magneto-optical technique (fd-FRS, frequency-domain Faraday rotation spectroscopy) for characterizing proteins using antibody-functionalized magnetic nanoparticles (MNPs) is demonstrated. This technique distinguishes between the Faraday rotation of the solvent, iron oxide core, and functionalization layers of polyethylene glycol polymers (spacer) and model antibody-antigen complexes (anti-BSA/BSA, bovine serum albumin). A detection sensitivity of ≈10 pg mL(-1) and broad detection range of 10 pg mL(-1) ≲ cBSA ≲ 100 µg mL(-1) are observed...
January 16, 2017: Small
https://www.readbyqxmd.com/read/28089818/notochordal-cell-derived-conditioned-medium-nccm-protects-human-nucleus-pulposus-cells-from-stress-induced-apoptosis
#7
Arne Mehrkens, Ajay Matta, M Zia Karim, Sarah Kim, Michael G Fehlings, Stefan Schaeren, W Mark Erwin
BACKGROUND CONTEXT: Degenerative Disc Disease (DDD) remains without an effective therapy and presents a costly burden to society. PURPOSE: Based upon prior reports concerning the effects of notochordal cell conditioned medium (NCCM) upon disc cells, we performed a proof of principle study to determine whether NCCM could reduce cytotoxic stress induced apoptosis in human disc nucleus pulpous (NP) cells. STUDY DESIGN/SETTING: 'in vitro' fundamental/basic science study METHODS: NP cells derived from 15 patients undergoing spinal surgery were treated with interleukin 1β (IL-1β) and Fas ligand (FasL) or etoposide in the presence of NCCM...
January 9, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28075157/visual-occlusion-during-minimally-invasive-surgery-a-contemporary-review-of-methods-to-reduce-laparoscopic-and-robotic-lens-fogging-and-other-sources-of-optical-loss
#8
Todd Galvin Manning, Marlon Perera, Daniel Christidis, Ned Kinnear, Shannon McGrath, Richard O'Beirne, Paul Zotov, Damien M Bolton, Nathan Lawrentschuk
Background Maintenance of optimal vision during minimally invasive surgery is crucial to maintaining operative awareness, efficiency and safety. Hampered vision is commonly caused by laparoscopic lens fogging (LLF) which has prompted the development of various anti-fogging fluids and warming devices. However, limited comparative evidence exists in contemporary literature. Despite technological advancements there remains no consensus as to superior methods to prevent LLF or restore visual acuity once LLF has occurred...
January 11, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28072758/how-to-escape-the-immune-response-what-tumours-have-to-teach-to-transplant-immunologists
#9
Guillaume Claisse, Olivier Thaunat, Christiane Mousson, Kathryn J Wood, Gérard Rifle, Christophe Mariat
Recent progress in deciphering the mechanisms underlying the concepts of tumor immunosurveillance and immunoevasion has opened new opportunities for the development of effective anti-tumor therapies. Transplant physicians and immunologists have much to learn from those direct clinical translations of basic science. The 2016 Beaune Seminar in Transplant research brought together researchers from both fields to explore and discuss significant advances in cancer biology, immunotherapies and their potential impacts for the management of cancer in transplant recipients...
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28070260/relationship-between-bone-density-and-biochemical-markers-of-bone-among-two-groups-taking-carbamazepine-and-sodium-valproate-for-epilepsy-in-comparison-with-healthy-individuals-in-yazd
#10
Abolghasem Rahimdel, Ali Dehghan, Mahboubeh Abolhassani Moghadam, Ali Mellat Ardekani
INTRODUCTION: Chronic antiepileptic therapy has been associated with metabolic bone diseases including osteomalacia and osteoporosis. The aim of this study was to determine frequency of changes in biochemical and bone mineral density (BMD) in adults receiving valproaic acid (VPA) & carbamazepine (CBZ). METHODS: In a cross sectional study evaluating adults (age 20-50 y) epileptic patients receiving valproic acid or carbamazepine for at least 2 years. This study was conducted from May 2014 to May 2015 in Shahid Sadoughi Hospital of Yazd University of Medical Science, Yazd, Iran...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28065792/the-analgesic-effects-of-oxytocin-in-the-peripheral-and-central-nervous-system
#11
Qing Xin, Bo Bai, Wenyan Liu
Pain is a ubiquitously unpleasant feeling among humans as well as many animal species often caused by actual and potential tissue damage. However, it is absolutely crucial for our survival in many ways. Acute pain can signal the presence of danger or life-threatenting events, which help escape noxious stimuli. By contrast, when pain becomes chronic or persistent, it becomes an encumbrance and exerts deleterious effects to the body and mind, often co-occured with anxiety and depression. Additionaly, chronic pain is more or less an economic burden for the patients because it requires immediate medical treatments and seriously hinders pepople in their work...
January 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28065518/membranous-nephropathy-integrating-basic-science-into-improved-clinical-management
#12
REVIEW
Daniel C Cattran, Paul E Brenchley
Idiopathic membranous nephropathy (INM) remains a common cause of the nephrotic syndrome in adults. The autoimmune nature of IMN was clearly delineated in 2009 with the identification of the glomerular-deposited IgG to be a podocyte receptor, phospholipase A2 receptor (PLA2R) in 70% to 75% of cases. This anti-PLA2R autoantibody, predominantly the IgG4 subclass, has been quantitated in serum using an enzyme-linked immunosorbent assay and has been used to aid diagnosis and monitor response to immunosuppressive therapy...
January 5, 2017: Kidney International
https://www.readbyqxmd.com/read/28061902/disposal-practices-of-unused-and-expired-pharmaceuticals-among-general-public-in-kabul
#13
Mohammadk Bashaar, Vijay Thawani, Mohamed Azmi Hassali, Fahad Saleem
BACKGROUND: Most of the medicine users remain unaware about the disposal of unused or expired medicines. The aim of this study was to know the disposal practices of unused and expired medicines among the general public in Kabul. METHODS: This was a descriptive, cross-sectional survey, conducted through face-to-face interviews using prevalidated structured questionnaire. Returned questionnaires were double-checked for accuracy. Statistical Package for Social Science (SPSS) version 23 was used for statistical analysis...
January 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28044941/design-synthesis-and-biological-evaluation-of-a-phenyl-butyric-acid-derivative-n-4-chlorophenyl-4-phenylbutanamide-a-hdac6-inhibitor-with-anti-proliferative-activity-on-cervix-cancer-and-leukemia-cells
#14
Rodríguez-Fonseca Rolando Alberto, Sixto-López Yudibeth, Fragoso-Vázquez M Jonathan, Flores-Mejía Raúl, Cabrera-Pérez Laura Cristina, Vázquez-Moctezuma Ismael, Rosales-Hernández Martha Cecilia, Bello Martiniano, M Martínez-Archundia, Trujillo-Ferrara José Guadalupe, Becerra-Martínez Elvia, Correa-Basurto José
The epigenetic regulation of genes in cancer could be targeted by inhibiting Histone deacetylase 6 (HDAC6), an enzyme involved in several types of cancer such as lymphoma, leukemia, ovarian cancer, etc. Through in silico methods, a set of Phenyl butyric acid derivatives with possible HDAC6 inhibitory activity were designed, rendering monophenylamides and biphenylamides using tubacin (HDAC6 selective inhibitor) as reference. The target compounds were submitted to theoretical ADMET analyses and their binding properties on different HDAC6 conformers were evaluated through docking calculations...
January 2, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28038955/traditional-chinese-medicine-for-pulmonary-fibrosis-therapy-progress-and-future
#15
REVIEW
Liu-Cheng Li, Lian-Di Kan
ETHNOPHARMACOLOGICAL RELEVANCE: Pulmonary fibrosis (PF) is a chronic, debilitating and often lethal lung disorder. Despite the molecular mechanisms of PF are gradually clear with numerous researchers' efforts, few effective drugs have been developed to reverse human PF or even halt the chronic progression to respiratory failure. Traditional Chinese medicine (TCM), the main component of the medical practice used for more than 5000 years especially in China, often exerts wider action spectrum than previously attempted options in treating human diseases...
December 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28034354/recombinant-activated-factor-vii-eptacog-alfa-activated-novoseven-%C3%A2-in-patients-with-rare-congenital-bleeding-disorders-a-systematic-review-on-its-use-in-surgical-procedures
#16
Matteo Nicola Dario Di Minno, Pasquale Ambrosino, Veronika A Myasoedova, Manuela Amato, Itala Ventre, Elena Tremoli, Alessandro Di Minno
In the absence of definite guidelines in the area, we have carried a systemic review to provide a thorough overview concerning the efficacy and safety of recombinant activated factor VII (rFVIIa, NovoSeven®, Novo Nordisk A/S, Bagsværd, Denmark) in patients with Glanzmann's thrombasthenia (GT) and FVII deficiency, undergoing surgical procedures. PubMed, Web of Science, Scopus and EMBASE databases was employed for the search. Three multicenter registries were identified: the Glanzmann's Thrombasthenia Registry (GTR), the Seven Treatment Evaluation Registry (STER), and a German post-marketing surveillance registry (the WIRK study)...
December 30, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28031836/pulmonary-alveolar-proteinosis-a-case-report-and-world-literature-review
#17
Armando J Huaringa, Wassem H Francis
Pulmonary alveolar proteinosis (PAP) is a lung disorder which was first described in 1958 by Rosen et al. and is indeed rare disease with a prevalence of 0.1 per 100,000 individuals. PAP is characterized by abnormal accumulation of pulmonary surfactant in the alveolar space, which impairs gas exchange leading to a severe hypoxemia. Pulmonary surfactant is an insoluble proteinaceous material that is rich in lipids and stains positive with periodic acid-Schiff (PAS). The most common type of PAP is the so-called autoimmune or idiopathic type...
November 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28027557/pathological-personality-development-after-the-chornobyl-disaster-and-the-anti-terrorist-operation
#18
K M Loganovsky, M V Gresko
: Objective of the study was to determine pathological changes of the personality of the clean up workers (liquida tors) of the Chornobyl accident and the participants in the anti terrorist operation (ATO) in Eastern Ukraine and radiation threat perception assessment.Design, object and methods. The cross sectional and retrospective assessments of the clean up workers of the Chornobyl accident (n = 185), evacuees from the Chornobyl Exclusion Zone (n = 112) from the randomized sample of individuals who are registered in the Clinical and epidemiological registry (CER) of the State Institution «National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine» [NRCRM] and partici pants of the ATO in Eastern Ukraine (n = 62) who underwent treatment and rehabilitation in the Department of Radiation Psychoneurology of the NRCRM Clinic have been done...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/28026910/participatory-policy-making-by-dairy-producers-to-reduce-anti-microbial-use-on-farms
#19
L van Dijk, A Hayton, D C J Main, A Booth, A King, D C Barrett, H J Buller, K K Reyher
Pressures for more responsible use of anti-microbial (AM) medicines in food animals are likely to increase from policymakers and the food industry, including retailers. To address this challenge, participatory approaches to welfare interventions and disease prevention may also be necessary alongside more conventional regulatory measures. This article describes the process of enabling groups of dairy producers to use a participatory policy making approach to develop an AM stewardship policy. The policy includes measures agreed to by all producers for more responsible use of AMs, whilst maintaining or improving dairy herd health and welfare...
December 27, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28026086/identification-of-serum-protein-markers-for-early-diagnosis-of-pregnancy-in-buffalo
#20
Lukumoni Buragohain, Trilok Nanda, Arnab Ghosh, Mayukh Ghosh, Rajesh Kumar, Sunil Kumar, Sambhu Sharan Gupta, Arpita Bharali, Ashok K Mohanty, Inderjeet Singh, Ashok Kumar Balhara
Improper or delayed pregnancy diagnosis has significant impact over animal production, particularly in buffaloes which inherently suffer from several reproductive inefficiencies. Thus the present study has undertaken to identify serum protein markers pertaining to early pregnancy diagnosis in buffaloes. Serum samples were collected from 10 pregnant Murrah Buffalo heifers at weekly intervals from days 0-35 post-artificial insemination and from 12 inseminated non-pregnant cyclic buffalo heifers on days 0, 7, 14 and 21...
December 27, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
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