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https://www.readbyqxmd.com/read/29332566/stimuli-responsive-nanoparticles-for-controlled-anti-cancer-drug-release
#1
Qi Tang, Bing Yu, Lilong Gao, Hailin Cong, Na Song, Chenghao Lu
Conventional drugs used for cancer chemotherapy have severe toxic side effects and show individually varied therapeutic responses. The convergence of nanotechnology, biology, material science and pharmacy offers a perspective strategy for cancer chemotherapy. Nanoparticles loaded with anti-cancer drug have been designed to overcome the limitations associated with conventional drugs, several nanomedicines have been approved by FDA and shown good performances in clinical practice. However, the therapeutic efficacies cannot be enhanced...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29332417/-concise-history-of-toxicology-from-empiric-knowledge-to-science
#2
Anna Tompa, Péter Balázs
Toxicology is a science of poisonings by xenobiotics and endogenous physiological changes. Its empiric roots may be traced back to the emerging of the human race because the most important pledge of our predecessors' survival was the differentiation between eatable and poisonous plants and animals. In the course of social evolution, there were three main fields of using poisons: 1) hunting and warfare, 2) to settle social tensions by avoiding military conflicts through hiding strategy of eliminating enemies by toxic substances, 3) medicines applied first as anti-poisons and later by introducing strong substances to defeat diseases, but paradoxically active euthanasia is also a part of the whole story...
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29331315/ethnobotany-phytochemistry-and-pharmacology-of-arctotis-arctotoides-l-f-o-hoffm-a-review
#3
REVIEW
Md Moshfekus Saleh-E-In, Johannes Van Staden
ETHNOPHARMACOLOGICAL RELEVANCE: Arctotis arctotoides (Asteraceae) is part of the genus Arctotis. Arctotis is an African genus of approximately 70 species that occur widely in the African continent with diverse medicinal values. This plant is used for the treatment of indigestion and catarrh of the stomach, epilepsy, topical wounds and skin disorders among the ethnic groups in South Africa and reported to have a wide spectrum of pharmacological properties. AIM OF THE REVIEW: The aim of the present review is to appraise the botany, traditional uses, phytochemistry, pharmacological potential, analytical methods and safety issues of A...
January 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29325127/inhibiting-trophoblast-par-1-overexpression-suppresses-sflt-1-induced-anti-angiogenesis-and-abnormal-vascular-remodeling-a-possible-therapeutic-approach-for-preeclampsia
#4
Yin Zhao, YanFang Zheng, XiaoXia Liu, QingQing Luo, Di Wu, XiaoPing Liu, Li Zou
STUDY QUESTION: Is it possible to improve vascular remodeling by inhibiting the excessive expression of protease activated receptor 1 (PAR-1) in trophoblast of abnormal placenta? SUMMARY ANSWER: Inhibition of trophoblast PAR-1 overexpression may promote placental angiogenesis and vascular remodeling, offering an alternative therapeutic approach for preeclampsia. WHAT IS KNOWN ALREADY: PAR-1 is high-affinity receptor of thrombin. Thrombin increases sFlt-1 secretion in trophoblast via the activation of PAR-1...
January 9, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29319217/the-science-behind-skin-care-moisturizers
#5
REVIEW
Zoe D Draelos
Moisturizers provide functional skin benefits, such as making the skin smooth and soft, increasing skin hydration, and improving skin optical characteristics; however, moisturizers also function as vehicles to deliver ingredients to the skin. These ingredients may be vitamins, botanical antioxidants, peptides, skin-lightening agents, botanical anti-inflammatories, or exfoliants. This discussion covers the science of moisturizers.
January 10, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29317888/antileishmanial-activity-of-lavandula-angustifolia-and-rosmarinus-officinalis-essential-oils-and-nano-emulsions-on-leishmania-major-mrho-ir-75-er
#6
Azar Shokri, Majid Saeedi, Mahdi Fakhar, Katayoun Morteza-Semnani, Masoud Keighobadi, Saeed Hosseini Teshnizi, Hamid Reza Kelidari, Siamak Sadjadi
Background: The aim of present study was to evaluate antileishmanial effects of Lavandula angustifolia (L. angustifolia) and Rosmarinus officinalis (R. officinalis) medicinal plants essential oils and nano-emulsions on Leishmania major (L. major). Methods: The present study was performed in Leishmaniasis Reference Lab at Mazandaran University of Medical Sciences, Iran during 2016-2017. The IC50 values were calculated in both the promastigote and amastigote stages in J774 macrophage in comparison with meglumine antimoniate (MA) as positive control...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29316318/a-perspective-review-on-the-materials-and-mechanisms-of-photo-assisted-chemical-reactions-under-light-and-dark-can-it-be-called-as-day-night-photocatalysis
#7
Sakar Mohan, Nguyen Chinh-Chien, Vu Manh-Hiep, Trong-On Do
The photo-assisted catalytic reaction, conventionally known as photocatalysis, is blooming into the field of energy and environmental applications. It is widely known that the discovery of TiO2-assited photochemical reactions has led to achieve several unique applications such as degradation of pollutants in water and air, hydrogen production through water splitting, fuel conversion, cancer treatment, anti-bacterial activity, self-cleaning glasses and concrete, etc. These multifaceted applications of this phenomenon can be enriched and expanded further if this process is equipped with more tools and functions...
January 8, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29308958/medically-unexplained-physical-symptoms-misunderstood-and-wrongly-treated-a-semiotic-perspective-on-chronic-pain
#8
Kari Irene H Busvold, Hilde Bondevik
Medically unexplained physical symptoms (MUPS) are a significant and increasing health issue in the western world. Chronic pain constitutes a considerable element of these symptoms, and the lack of a biomedical explanation of their cause challenges the clinical encounter. The limitations of biomedicine become evident in these encounters and expose the need for an expanded understanding of body and symptom. Semiotics, as an anti-dualistic meta-theory, closes the gap between natural science and the humanities and views the human body in an evolutionary and existential perspective...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29306937/the-effects-of-stress-and-meditation-on-the-immune-system-human-microbiota-and-epigenetics
#9
Ayman Mukerji Househam, Christine Tara Peterson, Deepak Chopra
Context • Globally, more than 25% of individuals are affected by anxiety and depression disorders. Meditation is gaining popularity in clinical settings and its treatment efficacy is being studied for a wide array of psychological and physiological ailments. An exploration of stress physiology is an essential precursor to delineation of the mechanisms underlying the beneficial effects of meditation practices. Objective • The review outlines a model of interconnected physiological processes that might support the continued inclusion and expansion of meditation in the treatment of diverse medical conditions and to investigate the role that gut microbiota may play in realizing well-being through meditation...
October 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/29306011/adaptation-of-human-gut-microbiota-to-bariatric-surgeries-in-morbidly-obese-patients-a-systematic-review
#10
Hanieh-Sadat Ejtahed, Pooneh Angoorani, Shirin Hasani-Ranjbar, Seyed-Davar Siadat, Nasrin Ghasemi, Bagher Larijani, Ahmad-Reza Soroush
BACKGROUND: Bariatric surgeries have turned to be a popular therapeutic option for morbid obesity nowadays. Gut microbiota is supposed to be responsible as a part of the bariatric surgeries success. In this systematic review, we detailed the human studies which investigated the effect of different bariatric surgeries on the composition of gut microbiota. METHODS: We did a comprehensive search in PubMed, Web of Science, and Scopus for all clinical trials and longitudinal observational studies documented up to December 2015...
January 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29305107/five-threads-how-u-shaped-thinking-weaves-together-dogs-men-selenium-and-prostate-cancer-risk
#11
REVIEW
David J Waters, Emily C Chiang
Prostate cancer is one of the leading causes of cancer-related mortality among men living in developed countries, making the development of safe, practical approaches to prostate cancer risk reduction a high research priority. The relationship between prostate cancer risk and selenium, an essential nutrient required for a number of metabolically important enzymes including glutathione peroxidases, has been investigated, but a satisfactory integration of results has proven elusive. Dogs, like men, naturally develop prostate cancer during aging, providing an appropriate context to study the effects of selenium supplementation on the dysregulation of homeostasis that drives cancer development within the aging prostate...
January 2, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29303338/enhanced-control-of-transient-raman-scattering-using-buffered-hydrogen-in-hollow-core-photonic-crystal-fibers
#12
P Hosseini, D Novoa, A Abdolvand, P St J Russell
Many reports on stimulated Raman scattering in mixtures of Raman-active and noble gases indicate that the addition of a dispersive buffer gas increases the phase mismatch to higher-order Stokes and anti-Stokes sidebands, resulting in a preferential conversion to the first few Stokes lines, accompanied by a significant reduction in the Raman gain due to collisions with gas molecules. Here we report that, provided the dispersion can be precisely controlled, the effective Raman gain in a gas-filled hollow-core photonic crystal fiber can actually be significantly enhanced when a buffer gas is added...
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29299877/cocoa-flavanol-supplementation-and-exercise-a-systematic-review
#13
REVIEW
Lieselot Decroix, Danusa Dias Soares, Romain Meeusen, Elsa Heyman, Cajsa Tonoli
BACKGROUND: Cocoa flavanols (CFs) have antioxidant and anti-inflammatory capacities and can improve vascular function. It has recently been suggested that CF intake may improve exercise performance and recovery. This systematic review aimed to evaluate the literature on the effects of CF intake on exercise performance and recovery and exercise-induced changes in vascular function, cognitive function, oxidative stress, inflammation, and metabolic parameters. METHODS: Two electronic databases (Pubmed and Web of Science) were searched for studies examining the combination of CF intake and exercise in humans (up to 28 March 2017)...
January 3, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29299431/a-review-on-botanicals-with-wound-healing-activity-for-pemphigus-vulgaris-perspective-of-traditional-persian-medicine-and-conventional-medicine
#14
REVIEW
Fatemeh Atarzadeh, Amir Mohammad Jaladat, Babak Daneshfard, Ladan Dastgheib, Mohammad Kamalinejad, Gholamreza Amin
Objective: As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Accordingly, we aimed to assess the treatment options suggested by traditional Persian medicine (TPM) and compare them with current findings. Materials and Methods: We studied the main clinical and pharmaceutical textbooks of TPM (Kitāb al-hāwīfī al-tibb, the Canon of Medicine, Eksir-e-Aazam, Tuhfat al-mu'minīn, Makhzan al-adviyah (focusing on the skin chapter and respective herbal remedies for the inflamed skin and ulcers...
November 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29288248/effect-of-conjugated-linoleic-acid-on-blood-inflammatory-markers-a-systematic-review-and-meta-analysis-on-randomized-controlled-trials
#15
REVIEW
Fahimeh Haghighatdoost, B Fatemeh Nobakht M Gh
BACKGROUND/OBJECTIVES: Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid with attractive biological activities. Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models. However, the effects of CLA treatment on the inflammatory markers in humans are controversial. Therefore, the objective of this study was to perform a systematic review and meta-analysis on controlled clinical trials (RCT) assessing the effects of CLA supplementation on the circulating inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)...
December 29, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29276113/ayurveda-and-the-science-of-aging
#16
REVIEW
Rammohan V Rao
Since time immemorial, humanity has been concerned with developing and preserving youthful vigor, and extending longevity by stopping or delaying the aging process. By 2030, one in five of the world population will be over 65 years old. Longevity and old age are accompanied with a variety of health challenges and population studies indicate that the elderly will use between three to five times more healthcare services compared to the younger population. Modern medicine has made a great deal of progress in understanding the aging process and in controlling age-associated health issues including heart attacks, strokes, diabetes, cancer, senility, and arthritis...
December 21, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29259944/the-comparison-of-sensitivity-and-specificity-of-elisa-based-microneutralization-test-with-hemagglutination-inhibition-test-to-evaluate-neutralizing-antibody-against-influenza-virus-h1n1
#17
Ahmad Tavakoli, Farhad Rezaei, Gazal Sadat Fatemi Nasab, Fatemeh Adjaminezhad-Fard, Zahra Noroozbabaei, Talat Mokhtari-Azad
Background: The most common serological assay to measure anti-influenza antibodies is hemagglutination inhibition (HI) assay. Recently, neutralizing antibodies against influenza virus infection or vaccination can also be detected using microneutralization assays and occasionally, have greater sensitivity than the standard HI assays. The study aimed to compare the sensitivity and specificity of ELISA-based microneutralization (microNT-ELISA) and conventional HI assays in order to detect influenza H1N1 virus antibodies...
December 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29250323/strategies-for-prevention-of-gastrointestinal-cancers-in-developing-countries-a-systematic-review
#18
Ahmad Zia Shams, Ulrike Haug
Background: Gastrointestinal cancers account for one third of total cancer incidence and mortality in developing countries. To date, there is no systematic synthesis of evidence regarding strategies to prevent gastrointestinal cancers in developing countries. We aimed to provide a systematic overview of studies evaluating strategies for prevention or early detection of the three most common gastrointestinal cancers (gastric, liver and colorectal cancer) in developing countries. Methods: We searched MEDLINE, Web of Science and WHO Global Index Medicus databases for relevant articles published until October 2016 using combinations of the search terms "gastrointestinal", "digestive system", "gastric", "liver", "colorectal", "cancer", "prevention", "early detection" and "developing country" (including names)...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29248538/enzyme-targeting-strategies-for-prevention-and-treatment-of-cancer-implications-for-cancer-therapy
#19
REVIEW
Mohammad Hassan Baig, Mohd Adil, Rosina Khan, Surendar Dhadi, Khurshid Ahmad, Gulam Rabbani, Tufail Bashir, Mohammad Azhar Imran, Fohad Mabood Husain, Eun Ju Lee, Mohammad Amjad Kamal, Inho Choi
Extensive growth of cancer in humans is a major cause of death. Numerous studies are being conducted to improve the early diagnosis, prevention, and treatment of cancer. Recent technological advancements in medical science and research indicate molecular target therapy holds much promise in cancer treatment. In the past, therapeutic and diagnostic targeting of non-glycolytic and glycolytic enzymes in cancer have been successful, and discoveries of biomarker enzymes in cancer hold promise for therapeutic treatments...
December 14, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29247497/the-prevalence-of-antibody-responses-against-staphylococcus-aureus-antigens-in-patients-with-atopic-dermatitis-a-systematic-review-and-meta-analysis
#20
REVIEW
J de Wit, J E E Totté, F J M van Buchem, S G M A Pasmans
Staphylococcus (S.) aureus plays a role in the pathogenesis of atopic dermatitis (AD), possibly via the expression of various virulence antigens. An altered antibody response towards these antigens might contribute to inflammation. We aimed to provide an overview of the varying prevalences and odds of antibody responses against S. aureus antigens in AD patients. Data were systematically obtained from Embase, Medline, Web of Science, Scopus, Cochrane, PubMed and Google Scholar (up to February 12th 2016). We selected all original observational and experimental studies assessing anti-staphylococcal antibodies in serum of AD patients...
December 16, 2017: British Journal of Dermatology
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