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https://www.readbyqxmd.com/read/28225198/adjunctive-steroid-therapy-versus-antibiotics-alone-for-acute-endophthalmitis-after-intraocular-procedure
#1
REVIEW
Carole H Kim, Monica F Chen, Anne L Coleman
BACKGROUND: Endophthalmitis refers to severe infection within the eye that involves the aqueous humor or vitreous humor, or both, and threatens vision. Most cases of endophthalmitis are exogenous (i.e. due to inoculation of organisms from an outside source), and most exogenous endophthalmitis is acute and occurs after an intraocular procedure. The mainstay of treatment is emergent administration of broad-spectrum intravitreous antibiotics. Due to their anti-inflammatory effects, steroids in conjunction with antibiotics have been proposed to be beneficial in endophthalmitis management...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28225095/high-index-hk0-faceted-platinum-concave-nanocubes-with-enhanced-peroxidase-like-activity-for-an-ultrasensitive-colorimetric-immunoassay-of-the-human-prostate-specific-antigen
#2
Zhuangqiang Gao, Shuzhen Lv, Mingdi Xu, Dianping Tang
Developing simple, high-efficiency non-enzyme bioassays is of great importance for modern analytical systems, but remains a significant challenge. One promising route is to utilize highly efficient nanocatalysts with the exposure of active crystal facets. Herein, we for the first time propose a novel colorimetric immunoassay for the ultrasensitive detection of the human prostate-specific antigen (PSA) based on using a unique type of nanolabel - high-index {hk0} faceted platinum concave nanocubes (HIF-Pt-CNCs)...
February 22, 2017: Analyst
https://www.readbyqxmd.com/read/28219375/state-of-the-art-in-anti-cancer-mabs
#3
REVIEW
S M Chiavenna, J P Jaworski, A Vendrell
Following Milstein's discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making of them a therapeutic option for many cancer types in the current clinical practice. Today, mAbs are being developed to target different molecules with different mechanisms of action and its target potential is unlimited. However, this huge and fast growing new field needs to be organized to better understand the treatment options we have to confront different cancer diseases...
February 20, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28216196/hypericum-perforatum-st-john-s-wort-beyond-depression-a-therapeutic-perspective-for-pain-conditions
#4
REVIEW
Nicoletta Galeotti
ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum perforatum L. (Hypericaceae), popularly called St. John's wort (SJW), has a rich historical background being one of the oldest used and most extensively investigated medicinal herbs. Many bioactivities and applications of SJW are listed in popular and in scientific literature, including antibacterial, antiviral, anti-inflammatory. In the last three decades many studies focused on the antidepressant activity of SJW extracts. However, several studies in recent years also described the antinociceptive and analgesic properties of SJW that validate the traditional uses of the plant in pain conditions...
February 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28214544/can-functional-magnetic-resonance-imaging-studies-help-with-the-optimization-of-health-messaging-for-lifestyle-behavior-change-a-systematic-review
#5
REVIEW
Maxine E Whelan, Paul S Morgan, Lauren B Sherar, Mark W Orme, Dale W Esliger
Unhealthy behaviors, including smoking, poor nutrition, excessive alcohol consumption, physical inactivity and sedentary lifestyles, are global risk factors for non-communicable diseases and premature death. Functional magnetic resonance imaging (fMRI) offers a unique approach to optimize health messages by examining how the brain responds to information relating to health. Our aim was to systematically review fMRI studies that have investigated variations in brain activation in response to health messages relating to (i) smoking; (ii) alcohol consumption; (iii) physical activity; (iv) diet; and (v) sedentary behavior...
February 15, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28201967/dipeptidyl-peptidase-4-inhibitor-induced-angioedema-an-overlooked-and-potentially-lethal-adverse-drug-reaction
#6
Susanne Irene Scott, Michelle Fog Andersen, Lise Aagaard, Christian Von Buchwald, Eva Rye Rasmussen
Introduction Angioedema is a potentially fatal adverse drug reaction of some medications, as swellings of the upper airways can cause death by asphyxiation. Angiotensin converting enzyme-inhibitors are widely known to cause angioedema but less is known about the association between dipeptidyl peptidase-4 inhibitors (gliptins) and angioedema. Dipeptidyl peptidase-4 inhibitors are anti-diabetic drugs used to improve glycaemic control. They, as a class effect, inadvertently affect the degradation of the vasoactive kinins bradykinin and substance P, both of which can cause angioedema due to vasodilatation and increase in vascular permeability in the capillaries...
February 14, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28195724/a-drug-of-such-damned-nature-challenges-and-opportunities-in-translational-platinum-drug-research
#7
Dorian M Cheff, Matthew D Hall
The platinum-based anti-cancer agents cisplatin, carboplatin and oxaliplatin, represent a spectacular translational science achievement. The basic research observations that led to the discovery of Pt complexes as DNA-binding agents that elicit cell arrest, the pre-clinical tumor regression studies, and the inorganic medicinal chemistry that led to clinical implementation of effective platinum complexes in the clinic, have fueled multi-disciplinary research into platinum-based drugs. While the successes are clear and the research activity continues, a significant window of time has passed since a new Pt drug has been approved for clinical use...
February 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28194545/to-stop-the-erosion-of-hope-the-dmard-category-and-the-place-of-semantics-in-modern-rheumatology
#8
Jonas Kure Buer
The category of disease-modifying anti-rheumatic drugs (DMARDs) emerged in the 1970s to describe drugs capable of altering the long-term destructive course of arthritis. It became a core concept in rheumatology's reorientation towards pharmaceuticals in the late twentieth century. By examining the earliest use of the term "disease-modifying" in scientific publications, this paper identifies the drugs that the category described when it first emerged. Leaning on systematic reviews of each of these drugs towards the end of their career in rheumatology, it then establishes that posterity would not recognize any of these early DMARDs as capable of altering the long-term course of the disease...
February 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28194178/role-of-helicobacter-pylori-eradication-therapy-on-platelet-recovery-in-chronic-immune-thrombocytopenic-purpura
#9
Khan Sheema, Ujjan Ikramdin, Naz Arshi, Naz Farah, Sheikh Imran
Background. Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys native platelets. In this condition an autoantibody is generated against a platelet antigen. ITP affects women more often than men and is more common in children than adults. Objective. To assess the effect of Helicobacter pylori eradication therapy (HPET) on platelet count in Helicobacter pylori associated chronic immune thrombocytopenic purpura (chronic ITP) in adult. Materials and Methods. It is an interventional prospective study conducted at Liaquat University of Medical and Health Sciences, Jamshoro, from 2014 to 2015...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28192672/smart-nanostructures-for-cargo-delivery-uncaging-and-activating-by-light
#10
Mahdi Karimi, Parham Sahandi Zangabad, Soodeh Baghaee-Ravari, Mahdi Ghazizadeh, Hamed Mirshekari, Michael R Hamblin
Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, etc. Among drug delivery systems (DDSs), smart nanocarriers that can respond to specific stimuli in their local environment represent a growing field. Nanoplatforms that can be activated by an external application of light, can be used for a wide variety of photo-activated therapies, (especially light-triggered DDSs) relying on photo-isomerization, photo-crosslinking/uncrosslinking, photo-reduction, etc...
February 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28190465/butein-in-health-and-disease-a-comprehensive-review
#11
REVIEW
Ganesan Padmavathi, Nand Kishor Roy, Devivasha Bordoloi, Frank Arfuso, Srishti Mishra, Gautam Sethi, Anupam Bishayee, Ajaikumar B Kunnumakkara
BACKGROUND: The risk of suffering from many chronic diseases seems to have made no improvement despite the advancement in medications available in the modern world. Moreover, the use of synthetic chemicals as medications has proved to worsen the scenario due to the various adverse side effects associated with them. PURPOSE: Extensive research on natural medicines provides ample evidence on the safety and efficacy of phytochemicals and nutraceuticals against diverse chronic ailments...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28178363/ranolazine-for-stable-angina-pectoris
#12
REVIEW
Carlos A Salazar, Juan E Basilio Flores, Liz E Veramendi Espinoza, Jhon W Mejia Dolores, Diego E Rey Rodriguez, César Loza Munárriz
BACKGROUND: Stable angina pectoris is a chronic medical condition with significant impact on mortality and quality of life; it can be macrovascular or microvascular in origin. Ranolazine is a second-line anti-anginal drug approved for use in people with stable angina. However, the effects of ranolazine for people with angina are considered to be modest, with uncertain clinical relevance. OBJECTIVES: To assess the effects of ranolazine on cardiovascular and non-cardiovascular mortality, all-cause mortality, quality of life, acute myocardial infarction incidence, angina episodes frequency and adverse events incidence in stable angina patients, used either as monotherapy or as add-on therapy, and compared to placebo or any other anti-anginal agent...
February 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28170093/topical-treatments-for-blepharokeratoconjunctivitis-in-children
#13
REVIEW
Michael O'Gallagher, Catey Bunce, Melanie Hingorani, Frank Larkin, Stephen Tuft, Annegret Dahlmann-Noor
BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and conjunctiva, and control of ocular surface inflammation...
February 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28166914/role-of-anti-tubercular-treatment-for-positive-endometrial-aspirate-dna-pcr-reproductive-outcome-in-infertile-patients-in-indian-setting-a-randomized-trial
#14
A Kriplani, A Bahadur, V Kulshrestha, N Agarwal, S Singh, U B Singh
AIMS: The aim of the study was to determine the effect of anti-tubercular therapy (ATT) versus no ATT on reproductive outcome in patients with positive endometrial aspirate DNA-PCR for tuberculosis. SETTINGS AND DESIGN: Department of Obstetrics and Gynecology in collaboration with the Department of Microbiology at the All India Institute of Medical Sciences, New Delhi, India. METHODS AND MATERIALS: This prospective randomized study was conducted on 100 women in the reproductive age group with primary or secondary infertility, attending the Gynecology OPD at AIIMS...
January 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28163985/reflux-and-voice-disorders-have-we-established-causality
#15
G Todd Schneider, Michael F Vaezi, David O Francis
A trend of attributing abnormal voice changes to reflux has gained momentum among medical professionals over the last few decades. Evidence supporting the connection between reflux and voice and the use of anti-reflux medication in patients with dysphonia is conflicting and deserves careful examination. In the current health care environment, it is important that medical decisions be based on science rather than anecdote and practice patterns. The goal of this review is to investigate the evidence linking reflux and voice changes...
September 2016: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/28163971/solving-the-puzzle-what-is-behind-our-forefathers-anti-inflammatory-remedies
#16
REVIEW
Javier Rodriguez Villanueva, Jorge Martín Esteban, Laura Rodríguez Villanueva
Inflammation is a ubiquitous host response in charge of restoring normal tissue structure and function but is a double-edged sword, as the uncontrolled or excessive process can lead to the injury of host cells, chronic inflammation, chronic diseases, and also neoplastic transformation. Throughout history, a wide range of species has been claimed to have anti-inflammatory effects worldwide. Among them, Angelica sinensis, Tropaeolum majus, Castilleja tenuiflora, Biophytum umbraculum, to name just a few, have attracted the scientific and general public attention in the last years...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28163699/a-systematic-review-of-in-vitro-and-in-vivo-activities-of-anti-toxoplasma-drugs-and-compounds-2006-2016
#17
REVIEW
Mahbobeh Montazeri, Mehdi Sharif, Shahabeddin Sarvi, Saeed Mehrzadi, Ehsan Ahmadpour, Ahmad Daryani
The currently available anti-Toxoplasma agents have serious limitations. This systematic review was performed to evaluate drugs and new compounds used for the treatment of toxoplasmosis. Data was systematically collected from published papers on the efficacy of drugs/compounds used against Toxoplasma gondii (T. gondii) globally during 2006-2016. The searched databases were PubMed, Google Scholar, Science Direct, ISI Web of Science, EBSCO, and Scopus. One hundred and eighteen papers were eligible for inclusion in this systematic review, which were both in vitro and in vivo studies...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28155599/a-critical-review-of-the-characterization-of-polyphenol-protein-interactions-and-of-their-potential-use-for-improving-food-quality
#18
Maria Rosa Perez-Gregorioa, Jesús Simal-Gándarab
BACKGROUND: Interest in protein-phenol interactions in biological systems has grown substantially in recent decades. METHODS: The interest has focused largely on food systems in response to reports on the prominent roles of phenolic compounds in nutrition and health. RESULTS: Phenolic compounds can have both favourable and adverse nutritional effects. Polyphenols are widely known for their antioxidant, anti-inflammatory, anticancer and antiaging properties; however, they have also been ascribed anti-nutritional effects resulting from interactions with some proteins and enzymes...
February 2, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28154787/survivors-solidarity-and-attachment-in-the-immediate-aftermath-of-the-typhoon-haiyan-philippines
#19
Andrea Bartolucci, Michele Magni
INTRODUCTION: Anti-social behavior and self-preservation are often assumed to be normal responses to threats and disasters; on the contrary, decades of research and empirical studies in social sciences showed that pro-social behaviors are frequently common and that solidarity is the typical response to a variety of threats. The main objective of this study is to investigate and describe survivors' behavior, especially solidarity, according to the presence of familiar persons and to the perception of physical danger, elaborating the framework of Mawson's social attachment theory...
January 9, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28151524/-from-popularization-to-participation-communicating-science-in-the-knowledge-society
#20
Antonio Scalari
Vaccines are among the scientific topics that draw most interest in the public sphere. The discussion, however, can produce polarization, eventually becoming a controversy between "supporters of science" and "antiscience people". The aggressiveness of some anti-vaxxers, and their resistance to scientific evidence, can induce the belief that the confrontation is worthless, because many think that the top-down approach is the only one that can be used. The premise of this approach is that the gap of information is the main barrier between the scientific community and the society...
2017: Recenti Progressi in Medicina
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