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https://www.readbyqxmd.com/read/29785317/a-rare-case-of-penile-metastases-as-a-harbinger-of-primary-pulmonary-adenosquamous-carcinoma
#1
Partha Hota, Tejas N Patel, Xiaofeng Zhao, Carrie Schneider, Omar Agosto
Although lung cancer has a high propensity for distant metastatic disease, penile metastases from primary lung neoplasms are considered particularly rare. A 71-year-old male presented to our hospital with a rapidly enlarging hard palpable penile mass. MR imaging demonstrated two penile masses centered in the left and right corpus cavernosa. Subsequent CT imaging revealed a spiculated pulmonary mass in the right upper lobe with PET/CT, MRI, and surgical exploration, demonstrating evidence of metastases to the left adrenal gland, right subscapularis muscle, brain, and small bowel...
2018: Case Reports in Radiology
https://www.readbyqxmd.com/read/29782301/lymphangioma-circumscriptum-post-radiotherapy-for-penile-cancer-treated-with-co%C3%A2-laser
#2
Dietmar Schulz, Andreas Lein, Ancuta Proca Nicula, Katrin Schierle, Caius Solovan
Lymphangioma circumscriptum (LC) is a rare, benign condition, predominantly characterized by the malformation of lymphatic skin vessels. Its onset may be congenital or due to secondary causes such as radiotherapy, infections, or surgical procedures. We present the case of a 55-year-old patient with a pathologic history of squamous cell carcinoma of the penis followed by radical penectomy. Due to metastasis to the locoregional lymph nodes, the entire affected area was subsequently treated with radiation therapy, receiving a total dose of 55...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29776329/convaq-a-web-tool-for-copy-number-variation-based-association-studies
#3
Simon Jonas Larsen, Luisa Matos do Canto, Silvia Regina Rogatto, Jan Baumbach
BACKGROUND: Copy number variations (CNVs) are large segments of the genome that are duplicated or deleted. Structural variations in the genome have been linked to many complex diseases. Similar to how genome-wide association studies (GWAS) have helped discover single-nucleotide polymorphisms linked to disease phenotypes, the extension of GWAS to CNVs has aided the discovery of structural variants associated with human traits and diseases. RESULTS: We present CoNVaQ, an easy-to-use web-based tool for CNV-based association studies...
May 18, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29753463/de-novo-urologic-malignancies-in-renal-transplant-recipients
#4
H Antunes, E Tavares-da-Silva, R Oliveira, J Carvalho, B Parada, C Bastos, A Figueiredo
BACKGROUND: Immunosuppressed organ transplant patients have an elevated risk of malignancies. The aim of this study was to determine the incidence of urologic malignancies in renal transplant recipients, as well as to evaluate their monitoring, treatment, and outcomes. METHODS: We conducted a retrospective single-center study of 2897 renal transplants between January 1987 and December 2016. Recipients presenting with de novo urologic malignancies were evaluated...
March 10, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29743937/epidemiologic-and-economic-burden-of-hpv-diseases-in-spain-implication-of-additional-5-types-from-the-9-valent-vaccine
#5
Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull, Nuria Perulero
Background: A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related diseases in Spain is consistent with that reported in European and global studies. The aim of the present study was to estimate the annual direct costs associated to the following HPV-related diseases: genital warts, high grade precancerous lesions and cancer of cervix, vulva, vagina, anus and penis and head and neck cancer, caused by genotypes included in the nonavalent (9vHPV) and quadrivalent vaccines (4vHPV), in Spanish men and women...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29731917/the-analysis-of-human-papillomavirus-dna-in-penile-cancer-tissue-by-in-situ-hybridization
#6
Daiji Takamoto, Takashi Kawahara, Jun Kasuga, Takeshi Sasaki, Masahiro Yao, Yasushi Yumura, Hiroji Uemura
Primary penile cancer is a rare disease. Higher incidence rates occur in underdeveloped countries. Many studies have suggested an association between human papillomavirus (HPV) infection and penile cancer. Although HPV can affect the squamous epithelium of the male genitalia similarly to the female genital tract, the association between penile cancer and HPV remains unclear. In the present study, the HPV gene expression was examined in penile cancer tissue using in situ hybridization (ISH). The present study included 41 cases in which penectomy was performed and 3 cases in which tumor resection was performed to treat pathologically-diagnosed penile cancer at Yokohama City University Medical Center, and its 7 affiliated hospitals between April 1990 and March 2010...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29731428/three-piece-inflatable-penile-prosthesis-placement-following-pelvic-radiation-technical-considerations-and-contemporary-outcomes
#7
Jeffrey Loh-Doyle, Mukul B Patil, Zein Nakhoda, Nima Nassiri, Wesley Yip, Kevin Wayne, Leo Doumanian, Stuart D Boyd
BACKGROUND: Pelvic radiation is a known risk factor for the development and progression of erectile dysfunction. When medical therapy fails, the 3-piece inflatable penile prosthesis (IPP) can offer patients a definitive treatment option. Because of radiation-induced vascular changes and tissue fibrosis, a careful surgical approach is necessary to avoid intraoperative complications and attain successful outcomes. Despite its widespread use in prostate cancer treatment, there are no contemporary studies examining the effects that pelvic radiation can have on 3-piece IPP placement and device survival...
May 3, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29730734/robotic-assisted-inguinal-lymphadenectomy-a-systematic-review
#8
REVIEW
Ioannis D Gkegkes, Evelyn Eleni Minis, Christos Iavazzo
BACKGROUND: Lymphadenectomy represents the standard treatment for various types of cancer. The introduction of robotics in lymph node dissection may have an important impact on post-lymphadenectomy complications. METHODS: A systematic literature review was performed. RESULTS: In our review, robotic inguinal lymphadenectomy was performed on 51 patients. Penile squamous cell carcinoma was the most common histological type of the primary neoplasia...
May 5, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29730280/impact-of-database-quality-in-knowledge-based-treatment-planning-for-prostate-cancer
#9
Phillip D H Wall, Robert L Carver, Jonas D Fontenot
PURPOSE: This article investigates dose-volume prediction improvements in a common knowledge-based planning (KBP) method using a Pareto plan database compared with using a conventional, clinical plan database. METHODS AND MATERIALS: Two plan databases were created using retrospective, anonymized data of 124 volumetric modulated arc therapy (VMAT) prostate cancer patients. The clinical plan database (CPD) contained planning data from each patient's clinically treated VMAT plan, which were manually optimized by various planners...
March 13, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29723462/-prevention-and-treatment-of-erectile-dysfunction-after-prostatectomy-an-update
#10
REVIEW
Peng Xu, Yin-Huai Wang
Prostate cancer has the highest incidence among malignant tumors of the urinary system in China. Radical prostatectomy (RP) is the most effective treatment for localized prostate cancer with a good long-term prognosis. Erectile dysfunction (ED) is a common complication after RP, which seriously affects the patient's quality of life. With the rising incidence and early diagnosis of prostate cancer, the proportion of young cases of RP is increasing, and so is the importance of the treatment of post-RP ED. The restoration of erectile function after RP is closely related to the timing of penile rehabilitation as well as to pre- and intra-operative measures such as surgical strategies and methods...
July 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29703686/risks-and-benefits-of-adjuvant-radiotherapy-after-inguinal-lymphadenectomy-in-node-positive-penile-cancer-a-systematic-review-by-the-european-association-of-urology-penile-cancer-guidelines-panel
#11
REVIEW
Richard Robinson, Lorenzo Marconi, Ekelechi MacPepple, Oliver W Hakenberg, Nick Watkin, Yuhong Yuan, Thomas Lam, Steven MacLennan, Temitope E Adewuyi, Alberto Coscione, Suks S Minhas, Eva M Compérat, Andrea Necchi
CONTEXT: Management of men with penile squamous cell carcinoma (PSCC) who have high-risk features following radical inguinal lymphadenectomy (ILND) remains controversial. European Association of Urology guidelines state that adjuvant inguinal radiotherapy (AIRT) is "not generally recommended". Despite this, many centres continue to offer AIRT to a subset of men. OBJECTIVE: To undertake a systematic review of the evidence on AIRT in node-positive men with PSCC...
April 24, 2018: European Urology
https://www.readbyqxmd.com/read/29696442/the-best-of-both-worlds-a-hybrid-approach-for-optimal-pre-and-intraoperative-identification-of-sentinel-lymph-nodes
#12
G H KleinJan, E van Werkhoven, N S van den Berg, M B Karakullukcu, H J M A A Zijlmans, J A van der Hage, B A van de Wiel, T Buckle, W M C Klop, S Horenblas, R A Valdés Olmos, H G van der Poel, F W B van Leeuwen
PURPOSE: Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how fluorescence-guidance can help realize improvements beyond the current state-of-the-art in sentinel node (SN) biopsy procedures, use of the hybrid tracer indocyanine green (ICG)-99m Tc-nancolloid was evaluated in a large cohort of patients. PATIENTS AND METHODS: A prospective trial was conducted (n = 501 procedures) in a heterogeneous cohort of 495 patients with different malignancies (skin malignancies, oral cavity cancer, penile cancer, prostate cancer and vulva cancer)...
April 25, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29684963/-penile-metastasis-from-invasive-bladder-carcinoma-diagnosed-by-needle-biopsy-a-case-report-and-literature-review
#13
Shunsuke Hori, Yozo Mitsui, Kuri Suzuki, Koichi Nakajima, Naobumi Tochigi, Kazutoshi Shibuya
A 62-year-old man presented to our hospital with the chief complaint of continuous penile pain and swelling for 4 months. Computed tomography and magnetic resonance imaging showed an invasive bladder tumor with penile, bone, and lymph node metastases. Needle biopsies of the bladder and penile lesions were obtained, and histological evaluation of these specimens revealed urothelial carcinoma, findings which are consistent with invasive bladder cancer with penile metastasis. After several therapeutic options were discussed with the patient, he decided toundergogeneral chemotherapy...
March 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29681264/predictors-of-lymph-node-status-in-penile-cancer-high-quality-administrative-datasets-give-us-insight-into-what-s-happening-in-our-own-backyard
#14
Luke T Lavallée
No abstract text is available yet for this article.
April 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29666004/biallelic-tp53-gain-of-function-mutations-in-rapidly-progressing-solid-tumors
#15
Christopher M Sande, Brian Chang, Varun Monga, Aaron D Bossler, Deqin Ma
Recent studies are discovering TP53 mutations with gain of function (GOF) properties that promote tumorigenesis via a variety of mechanisms. To our knowledge, all reported compound mutations are allelic. We identified two patients with biallelic GOF TP53 mutations in their tumors and a third with allelic compound variants. The correlation with p53 expression was also examined. Genomic DNA was extracted from formalin-fixed, paraffin-embedded tissue and mutational analysis was performed using Ion AmpliSeq™Cancer HotSpot Panel V2...
April 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29662627/analysis-of-the-pi3k-akt-mtor-pathway-in-penile-cancer-evaluation-of-a-therapeutically-targetable-pathway
#16
Anthony Adimonye, Elzbieta Stankiewicz, Sakunthala Kudahetti, Giorgia Trevisan, Brendan Tinwell, Cathy Corbishley, Yong-Jie Lu, Nick Watkin, Daniel Berney
Objectives: To determine whether phosphatidylinositol-4,5-bisphosphate 3- kinase, catalytic subunit alpha (PIK3CA) copy number gain is common and could prove a useful marker for the activation status of the PI3K-AKT-mTOR pathway in penile squamous cell carcinoma (PSCC). Methods: Fresh frozen tissue and archival blocks were collected from 24 PSCC patients with 15 matched normal penile epithelium (NPE) tissue from St George's Hospital. PIK3CA mutational and copy number status (CNS) was assessed via Sanger sequencing and fluorescence in-situ hybridisation, respectively...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29656798/a-comparative-study-of-two-types-of-organ-sparing-surgeries-for-early-stage-penile-cancer-wide-local-excision-vs-partial-penectomy
#17
Xiang Wan, Dachao Zheng, Chong Liu, Huan Xu, Minkai Xie, Juan Zhou, Hai-Jun Yao, Zhong Wang
INTRODUCTION: Till date, there have been few reports of comparative studies on the outcomes of these different treatment modalities. In this study, we have aimed to comparatively evaluate the quality-of-life parameters, including sexual function, urinary function, and health-related quality of life (HRQOL), in patients with early stage penile cancers who underwent two different organ-sparing surgeries. MATERIAL AND METHODS: From March 2012 to March 2015, we enrolled 15 patients with early stage penile cancers who underwent either wide local excision or partial penectomy as organ-sparing surgical treatments...
April 3, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29604228/a-study-into-the-association-between-local-recurrence-rates-and-surgical-resection-margins-in-organ-sparing-surgery-for-penile-squamous-cell-cancer
#18
Denosshan Sri, Arunan Sujenthiran, Wayne Lam, Janice Minter, Brendan E Tinwell, Catherine M Corbishley, Tet Yap, Davendra M Sharma, Benjamin E Ayres, Nick W Watkin
BACKGROUND: Organ sparing surgery (OSS) in the treatment of penile squamous cell cancer (SCCp) is well established. A 5 mm margin has previously been considered oncologically safe. OBJECTIVE: To evaluate the significance of close surgical margins in OSS and clinico-pathological factors that may influence local recurrence. PATIENTS AND METHODS: At our tertiary referral centre, between March 2001 and September 2012, 332 patients treated with OSS for SCCp had clear surgical margins...
March 31, 2018: BJU International
https://www.readbyqxmd.com/read/29589134/the-relationship-between-hpv-status-and-chemoradiotherapy-in-the-locoregional-control-of-penile-cancer
#19
Zhigang Yuan, Arash O Naghavi, Dominic Tang, Youngchul Kim, Kamran A Ahmed, Jasreman Dhillon, Anna R Giuliano, Philippe E Spiess, Peter A Johnstone
BACKGROUND: Penile cancer (PeCa) is a rare, aggressive malignancy often associated with the human papillomavirus (HPV). The practice of a personalized risk-adapted approach is not yet established. This study is to assess the relationship between HPV tumor status and chemoradiotherapy (CRT) in PeCa locoregional control (LRC). METHODS: We retrospectively identified patients with HPV status who were diagnosed with squamous cell carcinoma of the penis and treated with surgical resection between 1999 and 2016...
March 27, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29581680/sexuality-in-surgically-treated-carcinoma-penis-patients-and-their-partners
#20
Gajanan S Bhat, Girish Nelivigi, Vijayakumar Barude, Anuradha Shastry
Most common treatment offered to carcinoma penis patients is surgery. This results in not only mutilation of the genitals but also affects their sexuality. The treating physician fails to address the issue due to the paucity of the data in this regard. Hence, we decided to evaluate sexuality in these patients after surgical treatment for penile cancer. Most of the times, their partners also face problems of sex and sexuality, regarding which there is no literature. Hence, we decided to include their partners also in the study...
February 2018: Indian Journal of Surgery
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