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https://www.readbyqxmd.com/read/28614204/human-papillomavirus-hpv-genotypes-in-condylomas-intraepithelial-neoplasia-and-invasive-carcinoma-of-the-penis-using-laser-capture-microdissection-lcm-pcr-a-study-of-191-lesions-in-43-patients
#1
María J Fernández-Nestosa, Nuria Guimerà, Diego F Sanchez, Sofía Cañete-Portillo, Elsa F Velazquez, David Jenkins, Wim Quint, Antonio L Cubilla
Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28612588/analysis-of-knowledge-level-in-brasilian-students-about-human-papillomavirus-infection-and-development-of-penile-cancer
#2
George Kemil Abdalla, Emanuella Francisco Fajardo, Bruno Belmonte Martinelli Gomes, Thiago Mantello Bianco, Ana Karina Marques Salge, Eduardo Elias Vieira de Carvalho, Marlize Moura Dos Reis, Dayana Pousa Siqueira Abrahão, Douglas Reis Abdalla
Introduction: Human papillomavirus (HPV), belonging to the Papovavirida family, is the most prevalent sexually transmitted disease (STD) agent worldwide. In Brazil, it is estimated that there are 3-6 million people infected with HPV. Aim: The aim of this study was to evaluate the knowledge of young male students about penis cancer related to HPV infection. Methods: This exploratory and quantitative study was conducted to analyze answers of 242 male students attending a private college located in Uberaba city, Minas Gerais state, Brazil, during 2015...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28607383/isolation-detection-and-quantification-of-cancer-biomarkers-in-hpv-associated-malignancies
#3
Hakan Inan, Shuqi Wang, Fatih Inci, Murat Baday, Richard Zangar, Sailaja Kesiraju, Karen S Anderson, Brian T Cunningham, Utkan Demirci
Human Papillomavirus (HPV) infection has been recognized as the main etiologic factor in the development of various cancers including penile, vulva, oropharyngeal and cervical cancers. In the development of cancer, persistent HPV infections induce E6 and E7 oncoproteins, which promote cell proliferation and carcinogenesis resulting elevated levels of host antibodies (e.g., anti-HPV16 E7 antibody). Currently, these cancers are clinically diagnosed using invasive biopsy-based tests, which are performed only in centralized labs by experienced clinical staff using time-consuming and expensive tools and technologies...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28595454/predictors-of-adults-knowledge-and-awareness-of-hpv-hpv-associated-cancers-and-the-hpv-vaccine-implications-for-health-education
#4
Kimberly R McBride, Shipra Singh
High human papillomavirus (HPV) prevalence and low HPV vaccine uptake are significant public health concerns. Disparities in HPV-associated cancers and HPV vaccine uptake rates suggest the need for additional research examining factors associated with vaccine acceptance. This study assessed HPV awareness and knowledge and identified sociodemographic characteristics associated with HPV knowledge at the population level. Data from adult men ( n = 1,197) and women ( n = 1,906) who participated in the National Cancer Institute's 2014 Health Information National Trends Survey were analyzed...
June 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28593860/evolving-adoptive-cellular-therapies-in-urological-malignancies
#5
REVIEW
Yien Ning Sophia Wong, Kroopa Joshi, Martin Pule, Karl S Peggs, Charles Swanton, Sergio A Quezada, Mark Linch
Immunotherapies have long been used to treat urological cancers but rarely lead to cure. In the past 5 years, success of immune checkpoint inhibition has led to a resurgence of enthusiasm for immunotherapy in the treatment of solid tumours. Increased understanding of tumour immune biology, technological advancements of gene transfer and cell culture, and improved clinical infrastructures for routine delivery of cell products, has made cell-based immunotherapeutics a real prospect for cancer therapy. These scientific and clinical activities, attempting to exploit the innate and adaptive immune systems for therapeutic gain, are well exemplified by the urological malignancies of renal, bladder, prostate, and penile cancer, a group of anatomically localised diseases, each with a distinct biology and different immunotherapeutic challenges...
June 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28589730/variation-in-genital-human-papillomavirus-infection-prevalence-and-vaccination-coverage-among-men-and-women-in-the-usa
#6
Jasmine J Han, Christopher M Tarney, John Song
Human papillomavirus (HPV) is the most common sexually transmitted infection that causes majority of anogenital and oropharyngeal cancers. Prophylactic HPV vaccine is available for the primary prevention of cancer and HPV transmission. Here, we are going to discuss the variation of HPV prevalence, HPV vaccination coverage and potential risk factors of men and women, retrieved from the cross-sectional study of the National Health Nutrition Examination Survey, a representative sample of noninstitutionalized, civilian residents in the USA...
June 7, 2017: Future Oncology
https://www.readbyqxmd.com/read/28579068/the-impact-of-age-on-urethroplasty-success
#7
Mya Levy, Ronak A Gor, Alex J Vanni, Kristian Stensland, Bradley A Erickson, Jeremy B Myers, Bryan B Voelzke, Thomas G Smith, Benjamin N Breyer, Christopher McClung, Nejd F Alsikafi, Yunhua Fan, Sean P Elliott
OBJECTIVE: To determine if age is an independent predictor of surgical success in patients undergoing urethroplasty. Urethroplasty performed by excision and primary anastomosis depends on vascular collateralization. Successful augmented urethroplasty depends on graft neovascularization. Older patients have more comorbid conditions including peripheral vascular disease associated with reduced penile blood flow. MATERIALS AND METHODS: A retrospective review of urethroplasties from 11 institutions...
June 1, 2017: Urology
https://www.readbyqxmd.com/read/28578871/subclassification-of-pn3-staging-systems-for-penile-cancer-proposal-for-modification-of-the-current-tnm-classification
#8
Zhiyong Li, Shengjie Guo, Zhiming Wu, Hui Han, Zaishang Li, Yanjun Wang, Dong Chen, Jieping Chen, Chuangzhong Deng, Zike Qin, Zhuowei Liu, Yonghong Li, Kai Yao, Fanjian Zhou
OBJECTIVE: To validate the clinical and prognostic significance of our proposed pN3 subclassification in penile cancer. MATERIALS AND METHODS: A retrospective analysis of 509 patients with penile cancer undergoing partial, total penectomy or inguinal lymphadenectomy or pelvic lymphadenectomy at Sun Yat-sen University Cancer Center was reevaluated by pathologists. pN3 stage was subclassified into pN3a (extranodal extension of any inguinal lymph node [LN] metastasis only) and pN3b (pelvic LN metastasis)...
May 31, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28567234/penile-inflammatory-skin-disorders-and-the-preventive-role-of-circumcision
#9
REVIEW
Brian J Morris, John N Krieger
Penile inflammatory skin conditions such as balanitis and posthitis are common, especially in uncircumcised males, and feature prominently in medical consultations. We conducted a systematic review of the medical literature on PubMed, EMBASE, and Cohrane databases using keywords "balanitis," "posthitis," "balanoposthitis," "lichen sclerosus," "penile inflammation," and "inflammation penis," along with "circumcision," "circumcised," and "uncircumcised." Balanitis is the most common inflammatory disease of the penis...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28564634/more-precise-prediction-in-chinese-patients-with-penile-squamous-cell-carcinoma-protein-kinase-ck2%C3%AE-catalytic-subunit-ck2%C3%AE-as-a-poor-prognosticator
#10
Zai-Shang Li, Chuang-Zhong Deng, Yun-Lin Ye, Kai Yao, Sheng-Jie Guo, Jie-Ping Chen, Yong-Hong Li, Zi-Ke Qin, Zhuo-Wei Liu, Bin Wang, Qi Zhao, Peng Chen, Qi-Wu Mi, Xiao-Feng Chen, Hui Han, Fang-Jian Zhou
PURPOSE: In this study, we assess the CK2α expression in human penile squamous cell carcinoma (SCC) and its clinical significance. METHODS: A total of 157 human penile SCC tissue samples were immunohistochemically analyzed. In addition, 12 human penile SCC and adjacent normal tissues were examined for CK2α protein and mRNA expression by Western blotting and real-time quantitative PCR, respectively. Survival was analyzed using the Kaplan-Meier test and the log-rank test...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28561704/new-developments-and-challenges-in-rare-genitourinary-tumors-non-urothelial-bladder-cancers-and-squamous-cell-cancers-of-the-penis
#11
Jeanny B Aragon-Ching, Lance C Pagliaro
The diagnosis and treatment of rare genitourinary tumors is inherently challenging. The Rare Diseases Act of 2002 initially defined a rare disorder as one that affects fewer than 200,000 Americans. The lack of widely available clinical guidelines, limited research funding, and inaccessible clinical trials often lead to difficulty with treatment decisions to guide practitioners in rendering effective care for patients with rare genitourinary cancers. This article will discuss basic tenets of diagnosis and treatment as well as recent developments and clinical trials in rare non-urothelial bladder cancers and penile squamous cell cancers...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28538494/committee-opinion-no-704-summary-human-papillomavirus-vaccination
#12
(no author information available yet)
Human papillomavirus (HPV) is associated with anogenital cancer (including cervical, vaginal, vulvar, penile, and anal), oropharyngeal cancer, and genital warts. The HPV vaccination significantly reduces the incidence of anogenital cancer and genital warts. Despite the benefits of HPV vaccines, only 41.9% of girls in the recommended age group, and only 28.1% of males in the recommended age group have received all recom-mended doses. Compared with many other countries, HPV vaccination rates in the United States are unacceptably low...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28533650/extensive-visceral-calcification-demonstrated-on-99m-tc-mdp-bone-scan-in-patient-with-carcinoma-penis-and-hypercalcemia-of-malignancy
#13
Sunny J Gandhi, Bhavdeep Rabadiya
Hypercalcemia is a common life-threatening complication associated with several malignancies. Parathyroid-related peptide has been shown to cause hypercalcemia in several solid tumors but rarely in penile cancer. We report a case of penile cancer with hypercalcemia causing metastatic visceral calcification in lungs, liver, and stomach detected on bone scan without significant abnormalities on CT scan.
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28522287/patterns-of-regional-lymphadenectomy-for-clinically-node-negative-patients-with-penile-carcinoma-analysis-from-the-national-cancer-database-from-1998-to-2012
#14
Juan Chipollini, Dominic H Tang, Pranav Sharma, Adam S Baumgarten, Philippe E Spiess
PURPOSE: Evidence supports upfront regional lymphadenectomy (rND) when primary penile tumors exhibit high-risk features and negative inguinal adenopathy (cN0). We sought to analyze trends in the utilization of early rND as well as assess factors associated with its use and survival outcomes using a nationwide cancer registry database. PATIENT AND METHODS: The National Cancer Database was queried for patients with clinically nonmetastatic penile carcinoma and available nodal status who underwent rND from 1998 to 2012...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28509699/penis-transplantation-first-us-experience
#15
Curtis L Cetrulo, Kai Li, Harry M Salinas, Matthew D Treiser, Ilse Schol, Glen W Barrisford, Francis J McGovern, Adam S Feldman, Michael T Grant, Cigdem Tanrikut, Jeffrey H Lee, Richard J Ehrlichman, Paul W Holzer, Garry M Choy, Raymond W Liu, Zhi Yang Ng, Alexandre G Lellouch, Josef M Kurtz, William G Austen, Jonathan M Winograd, Branko Bojovic, Kyle R Eberlin, Ivy A Rosales, Robert B Colvin, Dicken S C Ko
OBJECTIVE: We describe the first successful penis transplant in the United States in a patient with a history of subtotal penectomy for penile cancer. BACKGROUND: Penis transplantation represents a new paradigm in restoring anatomic appearance, urine conduit, and sexual function after genitourinary tissue loss. To date, only 2 penis transplants have been performed worldwide. METHODS: After institutional review board approval, extensive medical, surgical, and radiological evaluations of the patient were performed...
May 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28499559/identifying-psychosocial-distress-and-stressors-using-distress-screening-instruments-in-patients-with-localized-and-advanced-penile-cancer
#16
Désirée Louise Dräger, Chris Protzel, Oliver W Hakenberg
BACKGROUND: We examined the effects of treatment on the psychological well-being of patients with localized or advanced penile cancer using screening questionnaires to determine the consecutive need for psychosocial care. Penile cancer is a rare, but highly aggressive, malignancy. The psychological stress of patients with penile cancer arises from the cancer diagnosis per se and the corresponding consequences of treatment. In addition, cancer-specific distress results (eg, fear of metastasis, progression, relapse, death)...
April 21, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28493019/surgical-treatment-of-advanced-penile-cancer
#17
Ke Zhang, Xiang Wan, Huan Xu, Wenzhi Li, Juan Zhou, Ming-Xi Xu, Hai-Jun Yao, Zhong Wang
PURPOSE: To evaluate the therapeutic effect of surgery in patients with advanced penile cancer, who have a dismal prognosis. PATIENTS AND METHODS: Between September 2007 and July 2015, we treated 12 patients with surgical therapy. RESULTS: The median follow-up period for all the patients was 16 months (range 4-60 months). The outcome and concomitant symptoms were analyzed, and the survival rates were calculated. Three of the patients are currently alive...
May 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28487750/penile-melanoma-a-20-year-analysis-of-six-patients-at-the-national-cancer-institute-of-peru-lima
#18
Andres Guevara Jabiles, Edilberto Yabar Del Mar, Gilmer Arcenio Diaz Perez, Fernando Quiroa Vera, Luis Meza Montoya, Carlos Manuel Morante Deza
Melanoma of the urogenital tract is extremely rare, accounting for less than 0.1% of melanoma cases. The global literature currently describes only 220 cases of penile melanoma, most commonly located on the glans penis. RESULTS: Penile melanoma accounts for 0.7% of penile cancers and 0.18% of melanoma cases. The average patient age for the six cases we reviewed was 44.5 years. Three of these cases (50%) involved ulceration, one case (16.7%) involved lymphovascular invasion, and three cases (50%) involved mitosis ≥ 1 mm(2) (0...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28486384/human-papillomavirus-hpv-genotypes-in-condylomas-intraepithelial-neoplasia-and-invasive-carcinoma-of-the-penis-using-laser-capture-microdissection-lcm-pcr-a-study-of-191-lesions-in-43-patients
#19
María J Fernández-Nestosa, Nuria Guimerà, Diego F Sanchez, Sofía Cañete-Portillo, Elsa F Velazquez, David Jenkins, Wim Quint, Antonio L Cubilla
Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28483482/-sexual-consequences-after-treatment-of-prostate-cancer-inquiry-among-members-of-the-association-nationale-des-malades-du-cancer-de-la-prostate
#20
D Girier, A Chevrot, P Costa, R Thuret, A Faix, A Mestre, S Droupy
INTRODUCTION: Complications of prostate cancer treatments are responsible of a lower quality of life. We evaluated the prevalence and the perceptions of sexual consequences of prostate cancer treatments. MATERIALS AND METHODS: A retrospective self-administered questionnaire was sent to all the members of the Association Nationale des Malades du Cancer de la Prostate (ANAMACAP). All the answers were analyzed. RESULTS: 226 questionnaires were analyzed, the average age was 67...
May 2017: Progrès en Urologie
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