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https://www.readbyqxmd.com/read/27893841/seroprevalence-of-cutaneous-human-papillomaviruses-and-the-risk-of-external-genital-lesions-in-men-a-nested-case-control-study
#1
Shams Rahman, Dana E Rollison, Christine M Pierce Campbell, Tim Waterboer, Angelika Michel, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Wei Wang, Amy R Borenstein, Anna R Giuliano
BACKGROUND: A variety of cutaneous human papillomaviruses (HPV) are detectable in genital epithelial lesions in men and non-melanoma skin cancer patients. It remains unclear whether these viruses are associated causally with skin lesions. To date, no study has prospectively examined the association between cutaneous HPV seropositivity and development of external genital lesions (EGLs) in men. OBJECTIVES: To examine the association between seropositivity to cutaneous HPV types and the risk of subsequent development of EGLs...
2016: PloS One
https://www.readbyqxmd.com/read/27887019/first-case-of-penile-metastasis-following-abdominoperineal-resection-with-vram-flap-reconstruction
#2
Andrei A Kozan, Adrian M Smith, David W Ilsley, Nicholas Rhodes
Penile metastases are rare in colorectal cancer. We report the first case of such a recurrence in a patient who had undergone an extralevator abdominoperineal resection with vertical rectus abdominis myocutaneous flap perineal reconstruction. The patient was treated with curative intent by total penectomy.
November 24, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27881522/prevalence-of-papillomavirus-in-brazil-a-systematic-review-protocol
#3
Verônica Colpani, Augusto Bacelo Bidinotto, Maicon Falavigna, Silvana Pereira Giozza, Adele Schwartz Benzaken, Cristina Pimenta, Ana Goretti Kalume Maranhão, Carla Magda Allan Santos Domingues, Luciano Serpa Hammes, Eliana M Wendland
INTRODUCTION: Human papillomavirus (HPV) infection is a cause of premalignant and malignant cancer in the lower genital and digestive tracts. In Brazil, there have been no prevalence studies that included a nationwide sample, and the prevalence of HPV has not been determined in many regions. METHODS: We will search the EMBASE, LILACS, MEDLINE, Web of Science and SciELO databases and previously published review articles to identify original research articles assessing HPV prevalence of the perineal (cervical, penile and anal) and oral areas...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27872007/the-role-of-pde5-inhibitors-and-the-no-cgmp-pathway-in-cancer
#4
REVIEW
Taylor C Peak, Ashley Richman, Serap Gur, Faysal A Yafi, Wayne J G Hellstrom
INTRODUCTION: Phosphodiesterase 5 (PDE5) inhibitors (PDE5i) have been used clinically for the treatment of erectile dysfunction, acting on the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling pathway. Simultaneously, researchers have elucidated the roles that this pathway plays in the regulation of cell proliferation, tumor development, and progression. As a result, our knowledge of PDE5i and cancer biology has expanded and provides an integration that holds great promise for some, but concern for others...
January 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27864120/epidermal-growth-factor-receptor-as-an-adverse-survival-predictor-in-squamous-cell-carcinoma-of-the-penis
#5
Alice Muglia Thomaz da Silva Amancio, Isabela Werneck da Cunha, José Ivanildo Neves, Josiane da Silva Quetz, Dirce Maria Carraro, Rafael Malagoli Rocha, Stenio Cássio Zequi, Antonio Leopoldo Cubilla, Francisco Paulo da Fonseca, Ademar Lopes, Maria do Perpétuo Socorro Saldanha da Cunha, Marcos Venício Alves Lima, José Vassallo, Gustavo Cardoso Guimarães, Fernando Augusto Soares
Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted therapy in PC patients, although there is no test that provides accurate patient selection. The aim of the present study was to evaluate the prognostic value of EGFR gene and protein status in tumor samples from patients with primary penile squamous cell carcinoma (SCC)...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27862230/penile-compression-clamps-a-model-of-the-internal-mechanical-state-of-penile-soft-tissues
#6
Ayelet Levy, Mandy Fader, Daniel Bader, Amit Gefen
AIMS: Prostate cancer is the most frequently diagnosed male cancer and urinary incontinence represents a major consequence following surgery. Penile compression clamps (PCCs) which externally occlude the urethra may be used to manage the incontinence. Despite potential complication of PCCs, such as deformation-inflicted tissue damage, to date, there are no reported biomechanical criteria for design of PCCs, in terms of quantitative parameters for evaluating the safety-versus-efficacy of existing or future designs...
November 15, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27854558/the-association-between-unwanted-sexual-experiences-and-early-onset-cervical-cancer-and-precancer-by-age-25-a-case-control-study
#7
Yasmin Leela Jayasinghe, Victoria Sasongko, Rachel Wenrui Lim, Sonia Regina Grover, Sepehr N Tabrizi, Elya E Moore, Susan Donath, Suzanne Marie Garland
BACKGROUND: We examined the association between unwanted sexual experiences and cervical cancer, cervical intraepithelial neoplasia 3, adenocarcinoma in situ, diagnosed ≤25 years of age. METHODS: A case-control study of women ≤55 years who attended gynecological hospitals in Australia between 1983 and 2007. Cases were ≤25 years when diagnosed with disease, control group 1 were "older women" >25 years at diagnosis; control group 2 were "well women" ≤25 years attending preventive health clinics...
November 17, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27853841/sentinel-node-biopsy-and-lymphatic-mapping-in-penile-and-prostate-cancer
#8
H G van der Poel, P Meershoek, N Grivas, G KleinJan, F W B van Leeuwen, S Horenblas
BACKGROUND: Nodal metastases are linked to poor outcome in men with penile or prostate cancer. Early detection and resection are important for staging and for the prognosis. However, lymphadenectomy is associated with morbidity and may miss metastases when performed solely on the basis of anatomical templates. METHODS: In this article we describe the technique and benefits of sentinel node biopsy (SNB) and provide a review of the literature. RESULTS: Dynamic sentinel node techniques using both radioactive and optical (hybrid) tracers have been proven effective in penile cancer...
November 16, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27846930/-ccafu-french-national-guidelines-2016-2018-on-penile-cancer
#9
P Sèbe, L Ferretti, P-H Savoie, N Morel-Journel, A Fléchon, T Murez, L Rocher, P Camparo, A Méjean, X Durand
INTRODUCTION: The aim of this work is to establish guidelines proposed by the external genital organ group of the CCAFU for the diagnosis, treatment and follow-up of penile cancer. MATERIAL AND METHODS: The multidisciplinary working party studied 2013 guidelines exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The most common histological type is squamous cell carcinoma...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27824248/robot-assisted-lymphadenectomy-in-urology-pelvic-retroperitoneal-and-inguinal-a-systematic-review
#10
Giovannalberto Pini, Surena F Matin, Nazareno Suardi, Mihir Desai, Inderbir Gill, James Porter, Robert J Stein, Rene Sotelo, Franco Gaboardi, Francesco Porpiglia
Lymph node dissection represents an essential surgical step in the treatment of the most commonly treated urological cancers. The introduction of robotic surgery has lead to the possibility of treating these diseases with a minimally invasive surgical approach, but the surgical principles of open surgery need to be carefully respected in order to achieve comparable oncological results. Therefore, the robotic approach to urological cancers must include a carefully performed lymph node dissection when indicated...
November 8, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27822104/the-danish-national-penile-cancer-quality-database
#11
REVIEW
Jakob Kristian Jakobsen, Buket Öztürk, Mette Søgaard
AIM OF DATABASE: The Danish National Penile Cancer Quality database (DaPeCa-data) aims to improve the quality of cancer care and monitor the diagnosis, staging, and treatment of all incident penile cancer cases in Denmark. The aim is to assure referral practice, guideline adherence, and treatment and development of the database in order to enhance research opportunities and increase knowledge and survival outcomes of penile cancer. STUDY POPULATION: The DaPeCa-data registers all patients with newly diagnosed invasive squamous cell carcinoma of the penis in Denmark since June 2011...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27818285/down-regulation-of-microrna-146a-is-associated-with-high-risk-human-papillomavirus-infection-and-epidermal-growth-factor-receptor-overexpression-in-penile-squamous-cell-carcinoma
#12
Elektra Peta, Rocco Cappellesso, Giulia Masi, Alessandro Sinigaglia, Marta Trevisan, Angela Grassi, Barbara Di Camillo, Elisa Vassarotto, Ambrogio Fassina, Giorgio Palù, Luisa Barzon
Dysregulation of host microRNA expression has been involved in the development and progression of human papillomavirus (HPV)-related tumors. Analysis of miR-146a expression in a series of 59 penile squamous cell carcinomas (PSCCs) showed that its levels were lower in high-risk HPV-positive than in HPV-negative PSCCs and inversely correlated with expression of epidermal growth factor receptor (EGFR), a known target for miR-146a. Analysis of genotype distribution for rs2910164, a common functional polymorphism of miR-146a, did not identify correlations with miR-146a levels and EGFR expression in PSCCs...
November 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27813383/tumor-histologic-grade-is-the-most-important-prognostic-factor-in-patients-with-penile-cancer-and-clinically-negative-lymph-nodes-not-submitted-to-regional-lymphadenectomy
#13
Giuliano Amorim Aita, Stênio de Cássio Zequi, Walter Henriques da Costa, Gustavo Cardoso Guimarães, Fernando Augusto Soares, Thais Safranov Giuliangelis
INTRODUCTION: The presence and extension of inguinal lymph node metastasis are the main prognostic factors in patients with penile cancer. Physical exam and image exams are not adequate to evaluate inguinal lymph nodes and many patients are submitted to non-therapeutic lymphadenectomies. However, it is known that not all patients with clinically or histologically negative inguinal lymph nodes evolve favorably. CASUISTIC AND METHODS: the authors evaluated the clinical and pathologic characteristics of 163 patients with penile carcinoma and clinically negative inguinal lymph nodes followed for three or more years and their impact on global survival (GS) and cancer-specific survival (CSS) in the 10-year follow-up...
November 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27813379/penile-cancer-the-importance-to-predict-lymph-node-metastasis
#14
EDITORIAL
Luciano A Favorito
No abstract text is available yet for this article.
November 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27797359/penile-cancer-welcome-changes-in-disease-management-and-remaining-challenges
#15
Ben Ayres, Nick Watkin
No abstract text is available yet for this article.
October 31, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27792895/a-case-report-of-a-complete-degloving-injury-of-the-penile-skin
#16
Helena Aineskog, Fredrik Huss
INTRODUCTION: Male genital degloving injuries are unusual and rarely caused by animal bite. Usually patients attend health care immediately if bitten in the genital area. Prophylactic antibiotics is routinely used (Gomes et al., 2000). A penile degloving usually begins just proximal of the coronal line and progress down to the base of the shaft. Deep erectile tissue and the spermatic cord are seldom damaged and the endogenous skin of glans usually survives (Brown and Fryer, 1957; Morey et al...
October 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27792850/volume-outcome-relationship-in-penile-cancer-treatment-a-population-based-patterns-of-care-and-outcomes-study-from-australia
#17
Manish I Patel, Yuigi Yuminaga, Albert Bang, Nathan Lawrentschuk, Timothy Skyring, David P Smith
OBJECTIVES: To study the patterns of care of penile cancer diagnosed in the state of New South Wales (NSW) over a 10 year period and determine factors that are associated with differences in survival. PATIENTS AND METHODS: All invasive penile cancer diagnosed between 2001 and 2009 in NSW, Australia, were identified from the Central Cancer Registry. Records of treatment from the Admitted Patient Data Collection and deaths from the Registry of Births Deaths and Marriages were electronically linked...
October 2016: BJU International
https://www.readbyqxmd.com/read/27785442/dr-arthur-l-burnett-surgical-treatment-for-penile-cancer
#18
Lucine M Gao
No abstract text is available yet for this article.
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27784002/next-generation-sequencing-and-its-applications-in-hpv-associated-cancers
#19
Musaffe Tuna, Christopher I Amos
Approximately 18% of all human cancers have a viral etiology, and human papillomavirus (HPV) has been identified as one of the most prevalent viruses that plays causative role in nearly all cervical cancers and, in addition, in subset of head and neck, anal, penile and vulvar cancers. The recent introduction of next generation sequencing (NGS) and other 'omics' approaches have resulted in comprehensive knowledge on the pathogenesis of HPV-driven tumors. Specifically, these approaches have provided detailed information on genomic HPV integration sites, disrupted genes and pathways, and common and distinct genetic and epigenetic alterations in different human HPV-associated cancers...
October 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27772624/human-papillomavirus-in-kidney-transplant-recipients
#20
REVIEW
Peter V Chin-Hong
Human papillomavirus (HPV) is a common infection in kidney transplant recipients. HPV causes cervical, anal, vulvar, vaginal, penile and head and neck cancers. Kidney transplant recipients have a disproportionate burden of disease given prolonged immunosuppression. Given the long pre-invasive state of precancer lesions such as cervical intraepithelial neoplasia (CIN) and anal intraepithelial neoplasia (AIN) most HPV-cancers are preventable with screening and targeted treatment of disease. Pre-transplant vaccination of age-eligible kidney transplant recipients is otherwise ideal...
September 2016: Seminars in Nephrology
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