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https://www.readbyqxmd.com/read/28321461/-surgical-treatment-of-metastatic-penile-cancer-what-is-the-scientific-rationale
#1
O W Hakenberg, C Protzel
The treatment of metastases of penile cancer is confined to lymphatic metastases. Limited lymph node metastasis in penile cancer can be cured by radical lymph node surgery if complete removal of all lymph nodes of the region is achieved. Adjuvant chemotherapy is recommended. This approach applies to the regional lymph nodes of the inguinal and pelvic regions. Applying this concept to retroperitoneal lymph node metastases may also be reasonable in selected cases. The individual prognosis depends on the extent of lymphatic spread...
March 20, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28289930/the-importance-of-microvessel-density-in-predicting-cancer-progression-in-patients-with-penile-squamous-cell-carcinoma
#2
Aditi Arora, Ankur Bansal
PURPOSE: To evaluate the role of microvessel density (MVD) in predicting lymph node (LN) metastasis in penile squamous cell carcinoma (PSCC). MATERIALS AND METHODS: Records of 266 patients with PSCC were analyzed. Parameters examined were tumor stage, grade, nodal status, intratumoral and peritumoral MVD. Univariate and multivariate analyses were used to evaluate association between different histopathological variables and MVD. ROC was plotted to derive a prediction model using appropriate cutoff values of the parameters predicting cancer progression...
March 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28286072/organ-sparing-surgery-in-penile-cancer-a-systematic-review
#3
REVIEW
Mohamed H Kamel, Nabil Bissada, Renee Warford, Judy Farias, Rodney Davis
PURPOSE: Although penile cancer (PC) only represents 1% of all male cancers, the traditional treatment of total or subtotal penectomy carries devastating psychological and functional outcomes. Organ sparing surgery (OSS) in PC is an attractive option if it can provide satisfactory cancer control equivocal or near equivocal to standard techniques. In fact, these techniques are meeting increasing acceptance. Accordingly, the need to evaluate these options objectively is crucial in a comprehensive review is timely in order to increase awareness of these procedures, their applicability and provide guidance to the practicing urologist...
March 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28279147/dosimetric-comparison-and-evaluation-of-4-stereotactic-body-radiotherapy-techniques-for-the-treatment-of-prostate-cancer
#4
Jan Seppälä, Sami Suilamo, Mikko Tenhunen, Liisa Sailas, Heli Virsunen, Erna Kaleva, Jani Keyriläinen
PURPOSE: The aim of this study was to compare dosimetric characteristics, monitor unit, and delivery efficiency of 4 different stereotactic body radiotherapy techniques for the treatment of prostate cancer. METHODS: This study included 8 patients with localized prostate cancer. Dosimetric assets of 4 delivery techniques for stereotactic body radiotherapy were evaluated: robotic CyberKnife, noncoplanar intensity-modulated radiotherapy, and 2 intensity-modulated arc therapy techniques (RapidArc and Elekta volumetric-modulated arc therapy)...
April 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28262100/sexual-rehabilitation-after-treatment-for-prostate-cancer-part-2-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm-2015
#5
Andrea Salonia, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Mohit Khera
INTRODUCTION: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer. AIM: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction. METHODS: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016...
March 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28258954/prevalence-and-predicting-factors-for-commonly-neglected-sexual-side-effects-to-external-beam-radiation-therapy-for-prostate-cancer
#6
Anders Frey, Christian Pedersen, Henriette Lindberg, Rasmus Bisbjerg, Jens Sønksen, Mikkel Fode
INTRODUCTION: Changes in sexual function other than erectile dysfunction are sparsely investigated after radiation therapy for prostate cancer. AIM: To investigate orgasmic dysfunction, urinary incontinence during sexual activity, changes in penile morphology, and sensory disturbances in the penis in patients with prostate cancer treated with external-beam radiation therapy (EBRT). METHODS: In February 2015, men treated with EBRT at our center 3 months to 5 years previously (N = 519) received a study-specific questionnaire...
February 28, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28245440/human-papillomavirus-and-the-development-of-different-cancers
#7
Ge Gao, David I Smith
Human papillomaviruses (HPV) are responsible for the development of almost all cervical cancers. HPV is also found in 85% of anal cancer and in 50% of penile, vulvar, and vaginal cancers, and they are increasingly found in a subset of head and neck cancers, i.e., oropharyngeal squamous cell carcinomas (OPSCC). The model for how HPV causes cancer is derived from several decades of study on cervical cancer, and it is just presumed that this model is not only completely valid for cervical cancer but for all other HPV-driven cancers as well...
March 1, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28225964/penile-squamous-cell-carcinoma-a-review-of-the-literature-and-case-report-treated-with-mohs-micrographic-surgery
#8
Elizabeth Marchionne, Caroline Perez, Andrea Hui, Amor Khachemoune
The majority of penile carcinoma is squamous cell carcinoma. Although uncommon in the United States, it represents a larger proportion of cancers in the underdeveloped world. Invasive squamous cell carcinoma may arise from precursor lesions or de novo , and has been associated with lack of circumcision and HPV infection. Early diagnosis is imperative as lymphatic spread is associated with a poor prognosis. Radical surgical treatment is no longer the mainstay, and penile sparing treatments now are often used, including Mohs micrographic surgery...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28224100/early-infant-male-circumcision-systematic-review-risk-benefit-analysis-and-progress-in-policy
#9
Brian J Morris, Sean E Kennedy, Alex D Wodak, Adrian Mindel, David Golovsky, Leslie Schrieber, Eugenie R Lumbers, David J Handelsman, John B Ziegler
AIM: To determine whether recent evidence-based United States policies on male circumcision (MC) apply to comparable Anglophone countries, Australia and New Zealand. METHODS: Articles in 2005 through 2015 were retrieved from PubMed using the keyword "circumcision" together with 36 relevant subtopics. A further PubMed search was performed for articles published in 2016. Searches of the EMBASE and Cochrane databases did not yield additional citable articles. Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28217933/cytology-of-the-neovagina-in-transgender-women-and-individuals-with-congenital-or-acquired-absence-of-a-natural-vagina
#10
A Grosse, C Grosse, D Lenggenhager, B Bode, U Camenisch, P Bode
OBJECTIVE: The primary objective of this study was to describe the cytological findings of bowel and (penile) skin-lined neovaginas in patients with gender dysphoria (GD) and individuals with a congenital or acquired absence of a natural vagina. The secondary objective was to correlate the cytological findings with clinical characteristics such as oestrogen replacement therapy (ERT). METHODS: A retrospective review of an institutional pathology archive over a 15-year-period was performed to identify cytological samples of neovaginal vaults...
February 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28212473/-five-year-survival-analysis-in-patients-with-penile-cancer
#11
Álvaro José Montiel-Jarquín, Antonio Jesús Contreras-Díaz, Eduardo Vázquez-Cruz, Marco Antonio Chopin-Gazga, María Socorro Romero-Figueroa, Ivet Etchegaray-Morales, Ivan Alvarado-Ortega
BACKGROUND: Short-term survival of penile cancer is poor. The objective was to describe the 5-years penile cancer survival. METHODS: Retrospective cohort study. We included patients with penile cancer managed surgically from 2010 to 2014. Descriptive statistics were used for socio-demographic variables and the Kaplan-Meier estimator for survival function. RESULTS: We studied 22 patients with a mean age of 64.95 years and a time of evolution of 25 months after the diagnosis...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28178116/genital-human-papillomavirus-infection-in-indian-hiv-seropositive-men-who-have-sex-with-men
#12
Anantharam Raghavendran, Alexandra L Hernandez, Shelly Lensing, Manu Gnanamony, Rajiv Karthik, Murgesan Sivasubramanian, Rajesh Kannangai, Priya Abraham, Dilip Mathai, Joel M Palefsky
BACKGROUND: The incidence of penile cancer in Indian men is high. Little is known about genital human papillomavirus (HPV) infection in Indian HIV-seropositive men who have sex with men (MSM), a population that may be at particularly high risk for genital HPV infection and, potentially, penile cancer. In this study, we assessed the prevalence and risk factors for genital HPV infection in this population. DESIGN AND METHODS: Three hundred HIV-seropositive MSM were recruited from 2 clinical sites in India...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28175934/investigating-the-role-of-spect-ct-in-dynamic-sentinel-lymph-node-biopsy-for-penile-cancers
#13
Ziauddin Zia Saad, Savvas Omorphos, Sofia Michopoulou, Svetislav Gacinovic, Peter Malone, Raj Nigam, Asif Muneer, Jamshed Bomanji
PURPOSE: Currently, most centres use 2-D planar lymphoscintigraphy when performing dynamic sentinel lymph node biopsy in penile cancer patients with clinically impalpable inguinal nodes. This study aimed to investigate the role of SPECT/CT following 2-D planar lymphoscintigraphy (dynamic and static) in the detection and localization of sentinel lymph nodes in the groin. METHODS: A qualitative (visual) review was performed on planar followed by SPECT/CT lymphoscintigraphy in 115 consecutive patients (age 28-86 years) who underwent injection of (99m)Tc-nanocolloid followed by immediate acquisition of dynamic (20 min) and early static scans (5 min) initially and further delayed static (5 min) images at 120 min followed by SPECT/CT imaging...
February 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28166057/proton-therapy-of-prostate-cancer-by-anterior-oblique-beams-implications-of-setup-and-anatomy-variations
#14
M Moteabbed, A Trofimov, G C Sharp, Y Wang, A L Zietman, J A Efstathiou, H-M Lu
Proton therapy of prostate by anterior beams could offer an attractive option for treating patients with hip prosthesis and limiting the high-dose exposure to the rectum. We investigated the impact of setup and anatomy variations on the anterior-oblique (AO) proton plan dose, and strategies to manage these effects via range verification and adaptive delivery. Ten patients treated by bilateral (BL) passive-scattering proton therapy (79.2 Gy in 44 fractions) who underwent weekly verification CT scans were selected...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28142148/role-of-the-common-fragile-sites-in-cancers-with-a-human-papillomavirus-etiology
#15
Ge Gao, David I Smith
High-risk human papillomaviruses (HPVs) are known to be associated with different anogenital cancers including cervical, anal, penile, and vaginal cancers. They are also found to be responsible for the dramatic increases in oropharyngeal squamous cell carcinoma (OPSCC) observed in the United States and Europe. The model for how high-risk HPVs induce cancer formation comes from studies of cervical cancer which usually involves integration of the HPV into the human genome and subsequent changes due to induced chromosomal instability...
February 1, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28127185/veil-surgical-steps
#16
REVIEW
S K Raghunath, H Nagaraja, N Srivatsa
Inguinal lymphadenectomy remains the standard of care for metastatic nodal disease in cases of penile, urethral, vulval and vaginal cancers. Outcomes, including cure rates and overall and progression-free survivals, have progressively improved in these diseases with extending criteria to offer inguinal lymph node dissection for patients 'at-risk' for metastasis or loco-regional recurrence. Hence, despite declining incidence of advanced stages of these cancers, many patients will still need to undergo lymphadenectomy for optimal oncological outcomes...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28124520/should-routine-neonatal-circumcision-be-a-policy-to-prevent-penile-cancer-opinion-no
#17
EDITORIAL
Dominic H Tang, Philippe E Spiess
No abstract text is available yet for this article.
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28124519/should-routine-neonatal-circumcision-be-a-police-to-prevent-penile-cancer-opinion-yes
#18
EDITORIAL
Antonio Augusto Ornellas, Paulo Ornellas
No abstract text is available yet for this article.
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28122331/integrative-mirna-and-mrna-analysis-in-penile-carcinomas-reveals-markers-and-pathways-with-potential-clinical-impact
#19
Hellen Kuasne, Mateus C Barros-Filho, Ariane Busso-Lopes, Fábio A Marchi, Maisa Pinheiro, Juan J M Muñoz, Cristovam Scapulatempo-Neto, Eliney F Faria, Gustavo C Guimarães, Ademar Lopes, José C S Trindade-Filho, Maria Aparecida C Domingues, Sandra A Drigo, Silvia R Rogatto
Penile carcinoma (PeCa) is an important public health issue in poor and developing countries, and has only recently been explored in terms of genetic and epigenetic studies. Integrative data analysis is a powerful method for the identification of molecular drivers involved in cancer development and progression. miRNA and mRNA expression profiles followed by integrative analysis were investigated in 23 PeCa and 12 non-neoplastic penile tissues (NPT). Expression levels of eight miRNAs and 10 mRNAs were evaluated in the same set of samples used for microarray and in a validation set of cases (PeCa = 36; NPT = 27)...
January 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28118628/expression-and-clinical-significance-of-sox9-in-renal-cell-carcinoma-bladder-cancer-and-penile-cancer
#20
Yue-Ping Wan, Ming Xi, Hui-Chan He, Song Wan, Wei Hua, Zhao-Chang Zen, Yuan-Ling Liu, Yu-Lin Zhou, Ru-Jun Mo, Yang-Jia Zhuo, Hong-Wei Luo, Fu-Neng Jiang, Wei-De Zhong
BACKGROUND: Novel molecular markers are important diagnostic tools for the assessment of cancer progression and evaluation of effectiveness of the treatment. SOX9, a key regulator of developmental processes, is overexpressed in various neoplasms, such as prostate, breast, and colorectal cancers. However, the utilization of SOX9 as a biomarker for other urological cancers has not yet been investigated. METHODS: In the present study, paired patient tissue microarrays were analyzed by immunohistochemistry, and the SOX9 protein expression was quantitated as immunoreactive scores in patients with renal cell carcinoma (RCC), bladder cancer (BCa), and penile cancer (PC)...
2017: Oncology Research and Treatment
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