Read by QxMD icon Read

Penile cancer

Clemens Thoma
No abstract text is available yet for this article.
October 18, 2016: Nature Reviews. Urology
Jay P Reddy, Curtis A Pettaway, Lawrence B Levy, Lance C Pagliaro, Pheroze Tamboli, Priya Rao, Isuru Jayaratna, Karen E Hoffman
OBJECTIVE: To identify factors associated with regional recurrence (RR) following lymphadenectomy for penile cancer in order to determine which patients might benefit from adjuvant therapy. MATERIALS/METHODS: Men who underwent lymphadenectomy for penile squamous cell carcinoma from 1977-2014 were identified from an institutional database. Kaplan-Meier curves estimated recurrence-free survival (RFS) calculated from the date of lymphadenectomy. Cox regression models evaluated the association between RFS and patient and tumor characteristics...
October 18, 2016: BJU International
Sean R Williamson, Brett Delahunt, Cristina Magi-Galluzzi, Ferran Algaba, Lars Egevad, Thomas M Ulbright, Satish K Tickoo, John R Srigley, Jonathan I Epstein, Daniel M Berney
Since the last World Health Organization (WHO) Classification scheme for tumours of the urinary tract and male genital organs, there have been a number of advances in the understanding, classification, immunohistochemistry, and genetics of testicular germ cell tumours. The updated 2016 draft classification was discussed at an International Society of Urological Pathology (ISUP) Consultation on Testicular and Penile Cancer. This review addresses the main updates to germ cell tumour classification. Major changes include a pathogenetically derived classification using germ cell neoplasia in situ (GCNIS) as a new name for the precursor lesion, as well as distinction of prepubertal (non-GCNIS-derived) from postpubertal-type tumours (GCNIS-derived), acknowledging the existence of rare benign prepubertal-type teratomas in the postpubertal testis...
October 17, 2016: Histopathology
Arie S Parnham, Maarten Albersen, Varun Sahdev, Michelle Christodoulidou, Raj Nigam, Peter Malone, Alex Freeman, Asif Muneer
BACKGROUND: Penile cancer is a rare malignancy that is confined to the glans in up to four out of five cases. Although descriptions of glansectomy exist, there are no contemporary video explanations or large published single centre series. OBJECTIVE: To show the efficacy and safety of glansectomy and split-thickness skin graft (STSG) reconstruction. DESIGN, SETTING, AND PARTICIPANTS: Data were collected retrospectively for patients identified from surgical theatre diaries between February 2005 and January 2016...
October 13, 2016: European Urology
Varun Sahdev, Maarten Albersen, Michelle Christodoulidou, Arie Parnham, Peter Malone, Raj Nigam, Jamshed Bomanji, Asif Muneer
OBJECTIVES: To review the management and clinical outcomes of uni- or bilateral non-visualization of inguinal lymph nodes following dynamic sentinel lymph node biopsy (DSNB) in patients diagnosed with penile cancer and clinically impalpable inguinal lymph nodes (cN0). An additional objective was to develop an algorithm for the management of patients in which non-visualisation occurs. PATIENTS AND METHODS: This is a retrospective observational study over a period of 4 years comprising 166 patients with penile squamous cell carcinoma undergoing DSNB and followed up for a minimum of 6 months...
October 15, 2016: BJU International
Juan Xing, Somak Roy, Sara E Monaco, Liron Pantanowitz
BACKGROUND: Urinary diversion specimens from patients who undergo radical cystectomy are often submitted for urine cytology to screen for recurrent urothelial carcinoma. The objective of the current study was to investigate the frequency and cytohistologic features of cancer recurrence in diversion urine specimens. METHODS: A 10-year retrospective review of archival urinary diversion specimens was conducted. For abnormal cytology cases, cytology slides were reviewed, and their cytomorphology and available corresponding histopathology were documented...
October 14, 2016: Cancer
O R Brouwer, H G van der Poel, R F Bevers, E J van Gennep, S Horenblas
This review aims to discuss the current state-of-the-art of sentinel node (SN) mapping in urological malignancies. The principles and methodological aspects of lymphatic mapping and SN biopsy in urological malignancies are reviewed. Literature search was restricted to English language. The references of the retrieved articles were examined to identify additional articles. The review also includes meta-analyses published in the past 5 years. SN biopsy for penile cancer is recommended by the European Association of Urology as the preferred staging tool for clinically node-negative patients with at least T1G2 tumours (level of evidence 2a, Grade B)...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
Chengquan Ma, Yaguang Zhou, Sufen Zhou, Kun Zhao, Bingxin Lu, Erlin Sun
BACKGROUND AND AIM: High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in patients with penile cell carcinoma. METHODS: This retrospective research included 72 penile cancer patients with date about their serum fibrinogen value before surgery who undergone either partial or radical penectomy at The 2nd Hospital of Tianjin Medical University between January 2002 to January 2012...
October 11, 2016: Oncotarget
Eileen M Burd, Christina L Dean
Individuals with inherited immunodeficiencies, autoimmune disorders, organ or bone marrow transplantation, or infection with human immunodeficiency virus (HIV) are at increased risk of infection with both low-risk and high-risk human papillomavirus (HPV) types. Chronic immunosuppression provides an environment for persistent HPV infection which carries a higher risk of malignant transformation. Screening guidelines have been developed or advocated for processes that have detectable premalignant lesions, such as anal cancer or cervical cancer...
August 2016: Microbiology Spectrum
Philippe E Spiess
No abstract text is available yet for this article.
November 2016: Urologic Clinics of North America
Samir S Taneja
No abstract text is available yet for this article.
November 2016: Urologic Clinics of North America
Michael Bickell, Jonathan Beilan, Jared Wallen, Lucas Wiegand, Rafael Carrion
This article reviews the most up-to-date surgical treatment options for the reconstructive management of patients with penile, urethral, and scrotal cancer. Each organ system is examined individually. Techniques and discussion for penile cancer reconstruction include Mohs surgery, glans resurfacing, partial and total glansectomy, and phalloplasty. Included in the penile cancer reconstruction section is the use of penile prosthesis in phalloplasty patients after penectomy, tissue engineering in phallic regeneration, and penile transplantation...
November 2016: Urologic Clinics of North America
Jonathan H Huang, Matt Broggi, Adeboye O Osunkoya, Viraj A Master
Primary scrotal cancer is a rare urologic malignancy with various histologic subtypes. Management and outcomes are not designed optimally. Surgical excision is the recommended treatment for localized scrotal cancer, with assessment of the margins for disease. Closure of the defect can be performed with primary closure, skin grafts, flaps, or by secondary intention. Analysis of outcomes suggests that high-risk scrotal cancer may have a worse prognosis compared with penile cancer, and low-risk scrotal cancer may have a comparable prognosis...
November 2016: Urologic Clinics of North America
Shilpa Gupta, Guru Sonpavde
Penile squamous cell carcinoma (PSCC) is a rare cancer, but is more common in developing countries. Locally advanced and metastatic PSCC is associated with significant morbidity and mortality, with the prognosis remaining extremely poor. The authors searched PubMed and published abstracts for metastatic PSCC studies to describe emerging therapies. Multimodality treatment using chemotherapy, radiation, and consolidative surgery are standard of care. Utilizing anti-EGFR therapies and novel immunotheraputic approaches may help improve outcomes in PSCC...
November 2016: Urologic Clinics of North America
Praful Ravi, Lance C Pagliaro
A multimodal approach to therapy is increasingly used in treating men with advanced penile cancer. Adjuvant chemotherapy improves outcomes in chemotherapy-naïve men with node-positive positive disease, and neoadjuvant chemotherapy can downstage bulky nodal disease sufficiently to permit surgery and has the potential to offer durable long-term survival. However, there remain several unanswered questions in this field, and international collaboration in the form of clinical trials is required to optimize treatment and improve survival in men with advanced penile cancer...
November 2016: Urologic Clinics of North America
Pranav Sharma, Homayoun Zargar, Philippe E Spiess
Lymphadenectomy (LND) for locally advanced penile cancer is often necessary in patients with suspected disease within the inguinal or pelvic lymph nodes because the results of systemic therapy are somewhat marginal. It has utility in staging, disease prognosis, and treatment in certain men because early dissection of involved lymph nodes improves survival. Despite its mainstay in the management of this disease, inguinal and pelvic lymph node dissection can be associated with significant postoperative complications and patient morbidity...
November 2016: Urologic Clinics of North America
S Horenblas, S Minhas
Penile cancer is a rare genitourinary malignancy. Lymph node involvement is the single most important factor determining survival in these patients, and those patients with occult disease are difficult to identify on conventional cross-sectional imaging. Until recently, lymph node sampling (eg, lymphadenectomy) has been the diagnostic modality of choice in the detection of micrometastasis. More recently, several novel molecular and minimally invasive diagnostic techniques have been developed, which have been demonstrated to decrease the false-negative and -positive results of conventional imaging and lymphadenectomy...
November 2016: Urologic Clinics of North America
Juanita Crook
Squamous cell cancer of the penis is a radiocurable malignancy all too often managed solely by partial or total penectomy. Effective management of the primary tumor while preserving penile morphology and function is a priority. External radiotherapy and brachytherapy have a role to play in the definitive management of the primary tumor. Surgical nodal staging remains a cornerstone of management because it is the strongest predictor of survival, and inguinal status determines pelvic management. Postoperative radiotherapy of the regional nodes for high-risk pathology is indicated...
November 2016: Urologic Clinics of North America
Tharani Mahesan, Paul K Hegarty, Nicolas A Watkin
Penile-preserving surgery offers a revolutionary alternative to more traditional radical surgery. It offers better sexual, functional, and psychological results and evidence suggests it achieves this without sacrificing oncological outcomes. We examined the evolving nature of such surgeries, addressing controversies such as safe margins and survival outcomes and discussing more conventional techniques, including laser. At our UK center, we treat a high volume of penile cancer and here, based on such experience, we describe our glans resurfacing, glansectomy, and partial penectomy techniques; their application by disease stage; and the limitations of such surgeries...
November 2016: Urologic Clinics of North America
Gregory J Diorio, Anna R Giuliano
Penile cancer is a rare and devastating disease, especially at advanced stages. The etiology of penile cancer is multifactorial with multiple established risk factors including infection with the human papillomavirus (HPV). Approximately 40% of penile cancers are attributable to HPV, although the literature describing HPV as a prognostic factor is mixed. The pathogenesis of HPV infection as well as vaccination practices may provide valuable therapeutic agents to treat this rare and difficult disease.
November 2016: Urologic Clinics of North America
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"