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Penile cancer

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https://www.readbyqxmd.com/read/28522287/patterns-of-regional-lymphadenectomy-for-clinically-node-negative-patients-with-penile-carcinoma-analysis-from-the-national-cancer-database-from-1998-to-2012
#1
Juan Chipollini, Dominic H Tang, Pranav Sharma, Adam S Baumgarten, Philippe E Spiess
PURPOSE: Evidence supports upfront regional lymphadenectomy (rND) when primary penile tumors exhibit high-risk features and negative inguinal adenopathy (cN0). We sought to analyze trends in the utilization of early rND as well as assess factors associated with its use and survival outcomes using a nationwide cancer registry database. PATIENT AND METHODS: The National Cancer Database was queried for patients with clinically nonmetastatic penile carcinoma and available nodal status who underwent rND from 1998 to 2012...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28509699/penis-transplantation-first-us-experience
#2
Curtis L Cetrulo, Kai Li, Harry M Salinas, Matthew D Treiser, Ilse Schol, Glen W Barrisford, Francis J McGovern, Adam S Feldman, Michael T Grant, Cigdem Tanrikut, Jeffrey H Lee, Richard J Ehrlichman, Paul W Holzer, Garry M Choy, Raymond W Liu, Zhi Yang Ng, Alexandre G Lellouch, Josef M Kurtz, William G Austen, Jonathan M Winograd, Branko Bojovic, Kyle R Eberlin, Ivy A Rosales, Robert B Colvin, Dicken S C Ko
OBJECTIVE: We describe the first successful penis transplant in the United States in a patient with a history of subtotal penectomy for penile cancer. BACKGROUND: Penis transplantation represents a new paradigm in restoring anatomic appearance, urine conduit, and sexual function after genitourinary tissue loss. To date, only 2 penis transplants have been performed worldwide. METHODS: After institutional review board approval, extensive medical, surgical, and radiological evaluations of the patient were performed...
May 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28499559/identifying-psychosocial-distress-and-stressors-using-distress-screening-instruments-in-patients-with-localized-and-advanced-penile-cancer
#3
Désirée Louise Dräger, Chris Protzel, Oliver W Hakenberg
BACKGROUND: We examined the effects of treatment on the psychological well-being of patients with localized or advanced penile cancer using screening questionnaires to determine the consecutive need for psychosocial care. Penile cancer is a rare, but highly aggressive, malignancy. The psychological stress of patients with penile cancer arises from the cancer diagnosis per se and the corresponding consequences of treatment. In addition, cancer-specific distress results (eg, fear of metastasis, progression, relapse, death)...
April 21, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28493019/surgical-treatment-of-advanced-penile-cancer
#4
Ke Zhang, Xiang Wan, Huan Xu, Wenzhi Li, Juan Zhou, Ming-Xi Xu, Hai-Jun Yao, Zhong Wang
PURPOSE: To evaluate the therapeutic effect of surgery in patients with advanced penile cancer, who have a dismal prognosis. PATIENTS AND METHODS: Between September 2007 and July 2015, we treated 12 patients with surgical therapy. RESULTS: The median follow-up period for all the patients was 16 months (range 4-60 months). The outcome and concomitant symptoms were analyzed, and the survival rates were calculated. Three of the patients are currently alive...
May 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28487750/penile-melanoma-a-20-year-analysis-of-six-patients-at-the-national-cancer-institute-of-peru-lima
#5
Andres Guevara Jabiles, Edilberto Yabar Del Mar, Gilmer Arcenio Diaz Perez, Fernando Quiroa Vera, Luis Meza Montoya, Carlos Manuel Morante Deza
Melanoma of the urogenital tract is extremely rare, accounting for less than 0.1% of melanoma cases. The global literature currently describes only 220 cases of penile melanoma, most commonly located on the glans penis. RESULTS: Penile melanoma accounts for 0.7% of penile cancers and 0.18% of melanoma cases. The average patient age for the six cases we reviewed was 44.5 years. Three of these cases (50%) involved ulceration, one case (16.7%) involved lymphovascular invasion, and three cases (50%) involved mitosis ≥ 1 mm(2) (0...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28486384/human-papillomavirus-hpv-genotypes-in-condylomas-intraepithelial-neoplasia-and-invasive-carcinoma-of-the-penis-using-laser-capture-microdissection-lcm-pcr-a-study-of-191-lesions-in-43-patients
#6
María J Fernández-Nestosa, Nuria Guimerà, Diego F Sanchez, Sofía Cañete-Portillo, Elsa F Velazquez, David Jenkins, Wim Quint, Antonio L Cubilla
Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia (12 lesions, 10 patients), flat lesions (12 lesions, 5 patients), condylomas (26 lesions, 7 patients), penile intraepithelial neoplasia (PeIN) (115 lesions, 43 patients), and invasive squamous cell carcinomas (26 lesions, 26 patients). HPV was detected by whole-tissue section and LCM-PCR...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28483482/-sexual-consequences-after-treatment-of-prostate-cancer-inquiry-among-members-of-the-association-nationale-des-malades-du-cancer-de-la-prostate
#7
D Girier, A Chevrot, P Costa, R Thuret, A Faix, A Mestre, S Droupy
INTRODUCTION: Complications of prostate cancer treatments are responsible of a lower quality of life. We evaluated the prevalence and the perceptions of sexual consequences of prostate cancer treatments. MATERIALS AND METHODS: A retrospective self-administered questionnaire was sent to all the members of the Association Nationale des Malades du Cancer de la Prostate (ANAMACAP). All the answers were analyzed. RESULTS: 226 questionnaires were analyzed, the average age was 67...
May 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28476381/unusual-asymptomatic-presentation-of-bladder-cancer-metastatic-to-the-penis
#8
Francesca Giunchi, Francesco Vasuri, Vagnoni Valerio, Ilaria Montagnani, Federico Nelli, Michelangelo Fiorentino, Maria Rosaria Raspollini
Penile metastasis is an extremely rare event and mainly originate from primary pelvic tumor sites such us urinary bladder, gastro-intestinal tract and prostate and more rarely from respiratory system, bone tumors and melanoma. Here we describe the unusual presentation of two bladder urothelial cancer metastatic to the penis with no relevant clinical symptoms. Namely, a 69 years-old man with a warthy lesions of the foreskin and the glans misunderstood for a condylomata that at histological and immunohistochemical analysis showed a bladder urothelial carcinoma; and a 71 years-old man with reddish skin lesion of the glans, a previous history of bladder and urethral carcinoma and histological pagetoid spread of urothelial cancer to the glans...
December 2, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28460994/erectile-dysfunction-treatment-following-radical-cystoprostatectomy-analysis-of-a-nationwide-insurance-claims-database
#9
Meera R Chappidi, Max Kates, Nikolai A Sopko, Gregory A Joice, Jeffrey J Tosoian, Phillip M Pierorazio, Trinity J Bivalacqua
INTRODUCTION: To improve care for patients after radical cystoprostatectomy (RCP), focus on survivorship issues such as sexual function needs to increase. Previous studies have demonstrated the burden of erectile dysfunction (ED) after RCP to be as high as 89%. AIM: To determine the rates of ED treatment use (phosphodiesterase type 5 inhibitors, injectable therapies, urethral suppositories, vacuum erection devices, and penile prosthetics) in patients with bladder cancer before and after RCP to better understand current patterns of care...
April 28, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28459145/clinicopathologic-characteristics-and-treatment-outcomes-of-penile-cancer
#10
Jong Kil Nam, Dong Hoon Lee, Sung Woo Park, Sung Chul Kam, Ki Soo Lee, Tae Hyo Kim, Taek Sang Kim, Cheol Kyu Oh, Hyun Jun Park, Tae Nam Kim
PURPOSE: The aim of this study was to assess the clinicopathologic characteristics of penile cancer, including patterns of therapy, oncologic results, and survival. MATERIALS AND METHODS: Between January 2005 and July 2015, 71 patients at 6 institutions who had undergone penectomy or penile biopsy were enrolled. Their medical records were reviewed to identify the mode of therapy, pathology reports, and cancer-specific survival (CSS) rate. RESULTS: Clinicopathologic and outcome information was available for 52 male patients (mean age, 64...
April 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28450202/minimally-invasive-inguinal-lymphadenectomy-in-the-management-of-penile-carcinoma
#11
Christopher M Russell, Simpa S Salami, Adam Niemann, Alon Z Weizer, Scott A Tomlins, Todd M Morgan, Jeffrey S Montgomery
OBJECTIVE: To report and analyze the outcomes of endoscopic inguinal lymph node dissection (E-ILND), inclusive of video endoscopic ILND (VEIL) and robotic-assisted ILND (RAIL) approaches, in the largest reported series to date. MATERIALS AND METHODS: We retrospectively identified men with penile cancer who underwent E-ILND. Nodal resection volume, peri-operative parameters, and post-operative complications were assessed and analyzed. A subset analysis of complications by tumor and operative characteristics was performed to determine the impact of these variables on complication rates...
April 24, 2017: Urology
https://www.readbyqxmd.com/read/28424278/detection-of-hpv-subtypes-by-mass-spectrometry-in-ffpe-tissue-specimens-a-reliable-tool-for-routine-diagnostics
#12
Mark Kriegsmann, Petra Wandernoth, Katharina Lisenko, Rita Casadonte, Rémi Longuespée, Norbert Arens, Jörg Kriegsmann
AIMS: Human papilloma virus (HPV) infection is a causative agent for approximately 5% of all new cancer cases in humans. The virus is detected in cervical, anal, vaginal, penile, vulvar and head and neck cancers and has prognostic implications. Thus, test systems are required to detect high-risk but also low-risk HPV subtypes with high specificity and sensitivity in a time-effective and cost-effective manner. In the present study we developed a new mass spectrometry (MS)-based test system for the detection of HPV infections in formalin-fixed paraffin-embedded (FFPE) tissue samples...
May 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28411892/advanced-penile-cancer-with-iliac-lymph-node-involvement-treated-with-radiation-and-concurrent-gemcitabine
#13
A Lapierre, O Riou, A Fléchon, N Mottet, D Azria
Penile cancer is a rare entity with only 2000 new cases a year in the United States. Even though early stage penile cancer has an excellent prognosis, patients with positive pelvic lymph nodes have an overall 5-year survival rate under 10%. There is no consensus for the management of pelvic node-positive patients, although most guidelines are in favour of pelvic lymph node dissection for patients with two or more positive nodes, followed by adjuvant chemotherapy. We describe here the case of a patient with numerous metastatic lymph nodes at diagnosis, treated with chemoradiation (66Gy with concurrent gemcitabine) after failure of first-line chemotherapy and still alive and disease-free 7 years after diagnosis...
April 12, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28403538/human-papillomavirus-epstein-barr-virus-and-methylation-status-of-p16-ink4a-in-penile-cancer
#14
L A Afonso, F N Carestiato, A A Ornellas, P Ornellas, W M Rocha, T I Cordeiro, D C Lisboa, G Alves, Smb Cavalcanti
Little is known about penile carcinogenesis. The aim of this study was to evaluate the prevalence of HPV and EBV, and the methylation status of p16(ink4a) in penile cancer samples, and to contribute to the understanding of the mechanisms responsible for penile cancer development. HPV DNA was detected in 63.6% of 122 cases, with HPV16 being the most prevalent type. EBV DNA was detected in 47.7%, with EBV-1 being the most prevalent type. HPV/EBV co-infections were found in 27.3% of the cases. Hypermethylation in p16(ink4a) was detected in 64...
April 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28401957/contemporary-management-of-patients-with-penile-cancer-and-lymph-node-metastasis
#15
REVIEW
Andrew Leone, Gregory J Diorio, Curtis Pettaway, Viraj Master, Philippe E Spiess
Penile cancer is a rare disease that causes considerable physical and psychological patient morbidity, especially at advanced stages. Patients with low-stage nodal metastasis can achieve durable survival with surgery alone, but those with extensive locoregional metastasis have overall low survival. Contemporary management strategies for lymph node involvement in penile cancer aim to minimize the morbidity associated with traditional radical inguinal lymphadenectomy through appropriate risk stratification while optimizing oncological outcomes...
April 11, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28400857/estimation-of-the-overall-burden-of-cancers-precancerous-lesions-and-genital-warts-attributable-to-9-valent-hpv-vaccine-types-in-women-and-men-in-europe
#16
Susanne Hartwig, Jean Lacau St Guily, Géraldine Dominiak-Felden, Laia Alemany, Silvia de Sanjosé
BACKGROUND: In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital warts. We estimated the annual number of new cases of these diseases attributable to 9-valent HPV vaccine types in women and men in Europe. METHODS: The annual number of new cancers of the cervix, vulva, vagina, anus, penis, and selected head and neck sites in the population of the European Medicines Agency territory was estimated based on age-specific incidence rates extracted from Cancer Incidence in 5 Continents, Volume X and Eurostat population data for 2015...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28400085/distinguishing-failure-to-cure-from-complication-after-penile-prosthesis-implantation
#17
Miguel Pineda, Arthur L Burnett
BACKGROUND: A successful penile prosthesis implantation (PPI) surgery can be defined by outcomes beyond the absence of complications. AIM: To introduce the concept of failure to cure (FTC) in the context of PPI to more accurately gauge postoperative outcomes after PPI. METHODS: Consecutive patients from our sexual function registry who underwent PPI from January 2011 to December 2013 were analyzed. Demographics, previous treatment of erectile dysfunction, comorbidities, social history, postoperative problems (POPs), and surgical outcomes were tabulated...
April 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28394540/-penile-cancer
#18
A V Govorov, S V Smirnova, N V Vorob'ev, P V Shegai
No abstract text is available yet for this article.
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28387325/hpv-negative-penile-squamous-cell-carcinoma-disruptive-mutations-in-the-tp53-gene-are-common
#19
Karl Kashofer, Elke Winter, Iris Halbwedl, Andrea Thueringer, Marisa Kreiner, Stefan Sauer, Sigrid Regauer
The majority of penile squamous cell carcinomas is caused by transforming human papilloma virus (HPV) infection. The etiology of HPV-negative cancers is unclear, but TP53 mutations have been implicated. Archival tissues of 108 invasive squamous cell carcinoma from a single pathology institution in a low-incidence area were analyzed for HPV-DNA and p16(ink4a) overexpression and for TP53 mutations by ion torrent next-generation sequencing. Library preparation failed in 32/108 squamous cell carcinomas. Institutional review board approval was obtained...
April 7, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28381390/the-possible-role-of-davinci%C3%A2-robot-for-patients-with-vulval-carcinoma-undergoing-inguinal-lymph-node-dissection
#20
Christos Iavazzo, Paraskevi Evangelia Iavazzo, Ioannis D Gkegkes
Inguinal lymph node dissection represents the gold standard of treatment for patients with vulval carcinoma. The application of minimally invasive techniques, such as the robotics, in the surgical treatment of gynaecological cancer, reduced the rate of postoperative complications, having an important impact on the quality of patients' life. Robotic inguinal lymph node dissection is a safe and oncologically effective but expensive and time consuming approach in patients with penile cancer or melanoma. However, it is related with less postoperative complications especially less lymphocele or lymphoedema rates and can improve the patients' quality of life minimising the cost for health systems...
April 6, 2017: Journal of the Turkish German Gynecological Association
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