Philip A Leighton, Kathryn Ching, Kevin Reynolds, Christine N Vuong, Baisen Zeng, Yulei Zhang, Abheepsa Gupta, Jacqueline Morales, Gerry Sann Rivera, Devendra B Srivastava, Robyn Cotter, Darlene Pedersen, Ellen Collarini, Shelley Izquierdo, Marie-Cecile van de Lavoir, William Harriman
H chain-only Igs are naturally produced in camelids and sharks. Because these Abs lack the L chain, the Ag-binding domain is half the size of a traditional Ab, allowing this type of Ig to bind to targets in novel ways. Consequently, the H chain-only single-domain Ab (sdAb) structure has the potential to increase the repertoire and functional range of an active humoral immune system. The majority of vertebrates use the standard heterodimeric (both H and L chains) structure and do not produce sdAb format Igs...
April 17, 2024: Journal of Immunology