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https://www.readbyqxmd.com/read/28214088/a-case-of-seropositive-autoimmune-autonomic-ganglionopathy-with-diffuse-esophageal-spasm
#1
Nobutoshi Morimoto, Sakuma Takahashi, Tomoki Inaba, Motonori Takamiya, Yasuhiko Kageyama, Mizuki Morimoto, Yoshiaki Takahashi, Hirotake Nishimura, Shunya Nakane, Koji Abe
Autoimmune autonomic ganglionopathy (AAG) is an immune-mediated disorder that leads to various autonomic failures associated with anti-ganglionic acetylcholine receptor antibodies (anti-gAChR-Abs). Diffuse esophageal spasm (DES) is an uncommon esophageal motility disorder. We herein report the case of a 68-year-old woman with DES as a partial symptom of AAG. She presented with chronic esophageal transit failure, constipation, and numbness of the hands and feet, Adie's pupil, thermal hypoalgesia, and decreased deep tendon reflexes...
February 14, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28208779/proof-of-concept-of-integrated-load-measurement-in-3d-printed-structures
#2
Michaël Hinderdael, Zoé Jardon, Margot Lison, Dieter De Baere, Wim Devesse, Maria Strantza, Patrick Guillaume
Currently, research on structural health monitoring systems is focused on direct integration of the system into a component or structure. The latter results in a so-called smart structure. One example of a smart structure is a component with integrated strain sensing for continuous load monitoring. Additive manufacturing, or 3D printing, now also enables such integration of functions inside components. As a proof-of-concept, the Fused Deposition Modeling (FDM) technique was used to integrate a strain sensing element inside polymer (ABS) tensile test samples...
February 9, 2017: Sensors
https://www.readbyqxmd.com/read/28202613/the-activating-human-nk-cell-receptor-kir2ds2-recognizes-a-%C3%AE-2-microglobulin-independent-ligand-on-cancer-cells
#3
Lavanya Thiruchelvam-Kyle, Sigurd E Hoelsbrekken, Per C Saether, Elisabeth Gyllensten Bjørnsen, Daniela Pende, Sigbjørn Fossum, Michael R Daws, Erik Dissen
The functions of activating members of the killer cell Ig-like receptor (KIR) family are not fully understood, as the ligands for these receptors are largely unidentified. In this study, we report that KIR2DS2 reporter cells recognize a ligand expressed by cancer cell lines. All cancer targets recognized by KIR2DS2 were also recognized by KIR2DL2 and KIR2DL3 reporters. Trogocytosis of membrane proteins from the cancer targets was observed with responding reporter cells, indicating the formation of KIR2DS2 ligand-specific immunological synapses...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28188247/neurodegeneration-enhances-the-development-of-arthritis
#4
Stefanie C Lang, Ulrike Harre, Pavitra Purohit, Katharina Dietel, Deborah Kienhöfer, Jonas Hahn, Wolfgang Baum, Martin Herrmann, Georg Schett, Dirk Mielenz
The prevalence of neurodegenerative disease and arthritis increases with age. Despite both processes being associated with immune activation and inflammation, little is known about the mechanistic interactions between neurodegenerative disease and arthritis. In this article, we show that tau-transgenic (tau-tg) mice that develop neurodegenerative disease characterized by deposition of tau tangles in the brain are highly susceptible to developing arthritis. Already at steady-state conditions, tau-tg mice exhibit peripheral immune activation that is manifested by higher numbers of granulocytes, plasmablasts, and inflammatory Ly6C(hi) CCR2(+) monocytes, as well as increased levels of proinflammatory cytokines, such as TNF-α and IL-17...
February 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28187441/neutralization-of-interleukin-9-ameliorates-symptoms-of-allergic-rhinitis-by-reducing-th2-th9-and-th17-responses-and-increasing-the-treg-response-in-a-murine-model
#5
Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Cao
A novel independent Th-cell subset, characterized by high expression of interleukin (IL)-9, has been recognized as the "Th9" subset. Although Th9 cells are important in many diseases, their contribution to allergic rhinitis (AR) remains unclear. We therefore first determined whether Th9 cells were present in a mouse model of AR. We then investigated the their involvement in the distribution of CD4+ T-cell subsets and the symptoms of AR by treating mice with anti-IL-9 antibodies (Abs). Anti-IL-9 Abs were administered intranasally during rechallenge of ovalbumin (OVA)-induced AR in BALB/c mice...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28185743/differential-induction-of-anti-v3-crown-antibodies-with-cradle-and-ladle-binding-modes-in-response-to-hiv-1-envelope-vaccination
#6
Preetha Balasubramanian, Rajnish Kumar, Constance Williams, Vincenza Itri, Shixia Wang, Shan Lu, Ann J Hessell, Nancy L Haigwood, Faruk Sinangil, Keith W Higgins, Lily Liu, Liuzhe Li, Phillipe Nyambi, Miroslaw K Gorny, Maxim Totrov, Arthur Nadas, Xiang-Peng Kong, Susan Zolla-Pazner, Catarina E Hioe
The V3 loop in the HIV envelope gp120 is one of the immunogenic sites targeted by Abs. The V3 crown in particular has conserved structural elements recognized by cross-reactive neutralizing Abs, indicating its potential contribution in protection against HIV. Crystallographic analyses of anti-V3 crown mAbs in complex with the V3 peptides have revealed that these mAbs recognize the conserved sites on the V3 crown via two distinct strategies: a cradle-binding mode (V3C) and a ladle-binding (V3L) mode. However, almost all of the anti-V3 crown mAbs studied in the past were isolated from chronically HIV-infected individuals...
February 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28179413/cause-of-death-and-potentially-avoidable-deaths-in-australian-adults-with-intellectual-disability-using-retrospective-linked-data
#7
Julian Trollor, Preeyaporn Srasuebkul, Han Xu, Sophie Howlett
OBJECTIVES: To investigate mortality and its causes in adults over the age of 20 years with intellectual disability (ID). DESIGN, SETTING AND PARTICIPANTS: Retrospective population-based standardised mortality of the ID and Comparison cohorts. The ID cohort comprised 42 204 individuals who registered for disability services with ID as a primary or secondary diagnosis from 2005 to 2011 in New South Wales (NSW). The Comparison cohort was obtained from published deaths in NSW from the Australian Bureau of Statistics (ABS) from 2005 to 2011...
February 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28176002/dysfunction-of-the-blood-cerebrospinal-fluid-barrier-and-n-methyl-d-aspartate-glutamate-receptor-antibodies-in-dementias
#8
Mandy Busse, Ralf Kunschmann, Henrik Dobrowolny, Jessica Hoffmann, Bernhard Bogerts, Johann Steiner, Thomas Frodl, Stefan Busse
N-Methyl-D-aspartate glutamate receptor (NMDA-R) antibodies (Abs) could play a role in neurodegenerative disorders. Since, in these diseases, NMDA-R Abs were detected in serum, but only sporadic in cerebrospinal fluid (CSF), the origin and impact of the Abs are still unresolved. We examined the presence of NMDA-R Abs in serum and CSF using a cell-based immunofluorescence assay as well as the function of the blood-CSF-barrier (B-CSF-B) by determination of Q albumin (ratio of albumin in CSF and serum) in patients with mild cognitive impairment (MCI; N = 59) and different types of dementia, Alzheimer's disease (AD; N = 156), subcortical ischemic vascular dementia (SIVD; N = 61), and frontotemporal dementia (FTD; N = 34)...
February 8, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28171779/trunk-muscle-activity-during-different-variations-of-the-supine-plank-exercise
#9
Joaquin Calatayud, Jose Casaña, Fernando Martín, Markus D Jakobsen, Juan C Colado, Pedro Gargallo, Álvaro Juesas, Víctor Muñoz, Lars L Andersen
BACKGROUND: Exercises providing neuromuscular challenges of the spinal muscles are desired for core stability, which is important for workers with heavy manual labour as well as people recovering from back pain. PURPOSE: This study evaluated whether using a suspended modality increases trunk muscle activity during unilateral or bilateral isometric supine planks. DESIGN: Cross-sectional. METHODS: Twenty university students participated in this cross-sectional study...
January 31, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28166327/neurological-autoantibody-prevalence-in-epilepsy-of-unknown-etiology
#10
Divyanshu Dubey, Abdulradha Alqallaf, Ryan Hays, Matthew Freeman, Kevin Chen, Kan Ding, Mark Agostini, Steven Vernino
Importance: Autoimmune epilepsy is an underrecognized condition, and its true incidence is unknown. Identifying patients with an underlying autoimmune origin is critical because these patients' condition may remain refractory to conventional antiseizure medications but may respond to immunotherapy. Objective: To determine the prevalence of neurological autoantibodies (Abs) among adult patients with epilepsy of unknown etiology. Design, Setting, and Participants: Consecutive patients presenting to neurology services with new-onset epilepsy or established epilepsy of unknown etiology were identified...
February 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28165927/is-3d-printing-safe-analysis-of-the-thermal-treatment-of-thermoplastics-abs-pla-pet-and-nylon
#11
Szymon Wojtyła, Piotr Klama, Tomasz Baran
The fast development of low-cost desktop three-dimensional (3D) printers has made those devices widely accessible for goods manufacturing at home. However, is it safe? Users may belittle the effects or influences of pollutants (organic compounds and ultrafine particles) generated by the devices in question. Within the scope of this study, the authors attempt to investigate thermal decomposition of the following commonly used, commercially available thermoplastic filaments: acrylonitrile-butadiene-styrene (ABS), polylactic acid (PLA), polyethylene terephthalate (PET), and nylon...
February 6, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28164554/evaluation-of-a-modified-roche-enzymatic-ammonia-method-for-roche-cobas-6000-c501-module-automated-platform-when-5-%C3%A2%C2%B5l-improves-performance
#12
Christian Vassena, Marco Casati, Gabriele Sala, Vittoria Perlangeli, Sara Montagnese, Silvia Ippolito, Lucia Carati
BACKGROUND: We evaluated a modified Roche NH3L method developed by our group that significantly reduced the error flag "> ABS (> Absorbance)" on the COBAS 6000 (c501 module) automated platform. METHODS: Our study was finalized to validate the NH3L open method on COBAS 6000 (c501 module) with imprecision and correlation tests. In addition, the NH3L open method was evaluated for determination of lower limit of blank (LoB), lower limit of detection (LoD), and accuracy...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164137/immune-responses-to-tissue-restricted-nonmajor-histocompatibility-complex-antigens-in-allograft-rejection
#13
REVIEW
Ankit Bharat, T Mohanakumar
Chronic diseases that result in end-stage organ damage cause inflammation, which can reveal sequestered self-antigens (SAgs) in that organ and trigger autoimmunity. The thymus gland deletes self-reactive T-cells against ubiquitously expressed SAgs, while regulatory mechanisms in the periphery control immune responses to tissue-restricted SAgs. It is now established that T-cells reactive to SAgs present in certain organs (e.g., lungs, pancreas, and intestine) are incompletely eliminated, and the dysregulation of peripheral immuneregulation can generate immune responses to SAgs...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28161337/thermal-behavior-of-vehicle-plastic-blends-contained-acrylonitrile-butadiene-styrene-abs-in-pyrolysis-using-tg-ftir
#14
Guicai Liu, Yanfen Liao, Xiaoqian Ma
As important plastic blends in End-of-Life vehicles (ELV), pyrolysis profiles of ABS/PVC, ABS/PA6 and ABS/PC were investigated using thermogravimetric-Fourier transform infrared spectrometer (TG-FTIR). Also, CaCO3 was added as plastic filler to discuss its effects on the pyrolysis of these plastics. The results showed that the interaction between ABS and PVC made PVC pyrolysis earlier and HCl emission slightly accelerated. The mixing of ABS and PA6 made their decomposition temperature closer, and ketones in PA6 pyrolysis products were reduced...
February 1, 2017: Waste Management
https://www.readbyqxmd.com/read/28156181/formation-of-multimeric-antibodies-for-self-delivery-of-active-monomers
#15
Yaron Dekel, Yossy Machluf, Tal Gefen, Gennady Eidelshtein, Alexander Kotlyar, Yaron Bram, Ehud Shahar, Farah Reslane, Elina Aizenshtein, Jacob Pitcovski
Proteins and peptides have been used as drugs for almost a century. Technological advances in the past 30 years have enabled the production of pure, stable proteins in vast amounts. In contrast, administration of proteins based on their native active conformation (and thus necessitating the use of subcutaneous injections) has remained solely unchanged. The therapeutic anti-HER2 humanized monoclonal immunoglobulin (IgG) Trastuzumab (Herceptin) is a first line of the treatment for breast cancer. Chicken IgY is a commercially important polyclonal antibody (Ab)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28150581/a-novel-mother-to-child-htlv-1-transmission-model-for-investigating-the-role-of-maternal-anti-htlv-1-antibodies-using-orally-infected-mother-rats
#16
Yuji Murakami, Atsuhiko Hasegawa, Satomi Ando, Reiko Tanaka, Takao Masuda, Yuetsu Tanaka, Mari Kannagi
Human T-cell leukemia virus type 1 (HTLV-1) is a human retrovirus that is a causative agent of adult T-cell leukemia/lymphoma (ATL) and mainly transmitted from an infected mother to her child via breastfeeding. Such an HTLV-1 infection during childhood is believed to be a risk factor for ATL development. Although it has been suggested that an increased proviral load (PVL), a higher titer of antibody (Ab) in the infected mother, and prolonged breastfeeding are associated with an increased risk of mother-to-child transmission (MTCT), the mechanisms underlying MTCT of HTLV-1 remain largely unknown...
February 1, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28149820/comparison-of-the-hemostatic-effects-of-oxidized-cellulose-and-calcium-alginate-in-an-experimental-animal-model-of-hepatic-parenchymal-bleeding
#17
Mustafa Erman Dorterler, Harun Resit Ayangil, Cüneyt Turan, Kemal Deniz
BACKGROUND: Despite all recent developments, bleeding is still one of the main causes of increasing morbidity and mortality following both trauma and elective hepatic surgery. The main goal of treatment is stop the bleeding immediately. In this study, the hemostatic and histopathological effects of Ankaferd blood stopper (ABS), oxidized cellulose (OC), and calcium alginate (CA) were compared in an experimental liver injury. MATERIALS AND METHODS: Forty Wistar albino rats were randomly divided into four groups of ten animals each, receiving 0...
October 2016: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28147230/multimodal-and-polymorphic-interactions-between-anillin-and-actin-their-implications-for-cytokinesis
#18
Silvana Jananji, Cristina Risi, Indeewari K S Lindamulage, Louis-Philippe Picard, Robert Van Sciver, Guillaume Laflamme, Abe Albaghjati, Gilles R X Hickson, Benjamin H Kwok, Vitold E Galkin
Cytokinesis of animal cells requires the assembly of a contractile ring, which promotes daughter cell splitting. Anillin is a conserved scaffold protein involved in organizing the structural components of the contractile ring including filamentous actin (F-actin), myosin, and septins and in forming the subsequent midbody ring. Like other metazoan homologs, Drosophila anillin contains a conserved domain that can bind and bundle F-actin, but the importance and molecular details of its interaction with F-actin remain unclear...
January 29, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28144875/development-of-plastic-disks-containing-flame-retardants-for-elucidating-changes-in-their-concentrations-due-to-simulated-weathering-and-the-application-of-these-disks-to-weathering-tests
#19
Nobuyasu Hanari, Takamitsu Otake, Nobuyasu Itoh, Ayaka Wada, Masaki Ohata
Flame retardants (FRs) are useful because they can prevent combustion and delay the spread of fire after the ignition on commercial products containing plastics. However, such commercial products could be a primary source of environmental contamination with FRs. Plastic disks containing FRs were prepared to elucidate changes in the concentrations of the FRs after weathering tests. Acrylonitrile-butadiene-styrene (ABS) and polycarbonate (PC) resin were separately kneaded with a combination of three organic FRs [Dechlorane plus (DP), tetrabromobisphenol A (TBBPA), and triphenyl phosphate (TPhP)] and one inorganic FR [antimony trioxide (Sb2O3)]...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28142299/tgf-%C3%AE-1-protects-intestinal-integrity-and-influences-smads-and-mapk-signal-pathways-in-ipec-j2-after-tnf-%C3%AE-challenge
#20
Kan Xiao, Shuting Cao, Lefei Jiao, Zehe Song, Jianjun Lu, Caihong Hu
The aim of this study was to investigate the protective effects of TGF-β1 on intestinal epithelial barrier, as well as canonical Smad and MAPK signal pathways involved in these protection processes by a IPEC-J2 model stimulated with TNF-α. IPEC-J2 monolayers were treated without or with TNF-α in the absence or presence of TGF-β1. The results showed that TGF-β1 pretreatment ameliorated TNF-α-induced intestinal epithelial barrier disturbances as indicated by decrease of transepithelial electrical resistance (TER) and increase of paracellular permeability...
January 1, 2017: Innate Immunity
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