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Andrew Swayne, Linda Tjoa, Simon Broadley, Sasha Dionisio, David Gillis, Leslie Jacobson, Mark R Woodhall, Andrew McNabb, Daniel Schweitzer, Ben Tsang, Angela Vincent, Sarosh R Irani, Richard Wong, Patrick Waters, Stefan Blum
INTRODUCTION: Antibodies to glycine receptors (GlyR-Abs) were first defined in progressive encephalopathy with rigidity and myoclonus (PERM), but subsequently identified in other clinical presentations. We aimed to assess the clinical associations of all patients identified with GlyR-Abs in Queensland, Australia between April 2014 to May 2017, and compared these to cases reported in the literature. METHODS: A literature review identified the clinical features of all published GlyR-Ab positive cases through online databases...
June 15, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ngoc A Nguyen, Christopher C Bowland, Amit K Naskar
The article presents different mechanical, thermal and rheological data corresponding to the morphological formation within various renewable lignin-based composites containing acrylonitrile butadiene styrene (ABS), acrylonitrile butadiene rubber (NBR41, 41 mol% nitrile content), and carbon fibers (CFs). The data of 3D-printing properties and morphology of 3D-printed layers of selected lignin-based composites are revealed. This data is related to our recent research article entitled "A general method to improve 3D-printability and inter-layer adhesion in lignin-based composites" (Nguyen et al...
August 2018: Data in Brief
Hairul Hisham Bin Hamzah, Oliver Keattch, Derek Covill, Bhavik Anil Patel
Additive manufacturing also known as 3D printing is being utilised in electrochemistry to reproducibly develop complex geometries with conductive properties. In this study, we explored if the electrochemical behavior of 3D printed acrylonitrile butadiene styrene (ABS)/carbon black electrodes was influenced by printing direction. The electrodes were printed in both horizontal and vertical directions. The horizsontal direction resulted in a smooth surface (HPSS electrode) and a comparatively rougher surface (HPRS electrode) surface...
June 14, 2018: Scientific Reports
Maximilian Koblischke, Karin Stiasny, Stephan W Aberle, Stefan Malafa, Georgios Tschouchnikas, Julia Schwaiger, Michael Kundi, Franz X Heinz, Judith H Aberle
Zika virus (ZIKV) has recently caused explosive outbreaks in Pacific islands, South- and Central America. Like with other flaviviruses, protective immunity is strongly dependent on potently neutralizing antibodies (Abs) directed against the viral envelope protein E. Such Ab formation is promoted by CD4 T cells through direct interaction with B cells that present epitopes derived from E or other structural proteins of the virus. Here, we examined the extent and epitope dominance of CD4 T cell responses to capsid (C) and envelope proteins in Zika patients...
2018: Frontiers in Immunology
Chun-Pin Chiang, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Andy Sun
BACKGROUND/PURPOSE: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA+ RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs- RAS/BD) patients. METHODS: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA+ RAS/BD patients, 41 Abs- RAS/BD patients, and 126 healthy control subjects...
June 10, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Xiujie Gao, Yingfen Wen, Jian Wang, Wenxin Hong, Chunlin Li, Lingzhai Zhao, Chibiao Yin, Xia Jin, Fuchun Zhang, Lei Yu
BACKGROUND: Zika virus (ZIKV) had spread rapidly in the past few years in southern hemisphere where dengue virus (DENV) had caused epidemic problems for over half a century. The high degree of cross-reactivity of Envelope (E) protein specific antibody responses between ZIKV and DENV made it challenging to perform differential diagnosis between the two infections using standard ELISA method for E protein. METHODS: Using an IgG capture ELISA, we investigated the kinetics of nonstructural protein 1 (NS1) antibody response during natural ZIKV infection and the cross-reactivity to NS1 proteins using convalescent sera obtained from patients infected by either DENV or ZIKV...
June 14, 2018: BMC Infectious Diseases
Jennifer I Lai, Deeptak Verma, Chris Bailey-Kellogg, Margaret E Ackerman
Structure-based approaches to antigen design utilize insights from antibody (Ab):antigen interactions and a refined understanding of protective Ab responses to engineer novel antigens presenting epitopes with conformations relevant to eliciting or discovering protective humoral responses. For human immunodeficiency virus-1 (HIV-1), one model of protection is provided by broadly neutralizing Abs (bnAbs) against epitopes present in the closed prefusion trimeric conformation of HIV-1 envelope glycoprotein, such as the variable loops 1-2 (V1V2) apex...
June 12, 2018: Protein Engineering, Design & Selection: PEDS
Yuan-Chin Hsieh, Hsin-Ell Wang, Wen-Wei Lin, Steve R Roffler, Ta-Chun Cheng, Yu-Cheng Su, Jia-Je Li, Chao-Cheng Chen, Chun-Han Huang, Bing-Mae Chen, Jaw-Yuan Wang, Tian-Lu Cheng, Fang-Ming Chen
Rationale: Increasing frequency of human exposure to PEG-related products means that healthy people are likely to have pre-existing anti-PEG antibodies (pre-αPEG Ab). However, the influence of pre-αPEG Abs on the pharmacokinetics (PK) and therapeutic efficacy of LipoDox is unknown. Methods: We generated two pre-αPEG Ab mouse models. First, naïve mice were immunized with PEGylated protein to generate an endogenous αPEG Ab titer (endo αPEG). Second, monoclonal αPEG Abs were passively transferred (αPEG-PT) into naïve mice to establish a αPEG titer...
2018: Theranostics
Sanjesh Tiwari, Anuradha Patel, Sheo Mohan Prasad
The present study was undertaken to evaluate the metal toxicity alleviating effects of kinetin (KN, 10 nM) on growth, photosynthetic pigments and photochemistry of PS II in the cyanobacterium Nostoc muscorum exposed to chromium (CrVI ) stress (100 and 150 µM). Chromium declined growth, photosynthetic pigments (chlorophyll a, phycocyanin and carotenoids), photosynthetic oxygen evolution rate and parameters of fluorescence kinetics (ϕP0 , FV /F0 , ϕE0 , Ψ0 and PIABS except F0 /FV ) in concentration dependent manner, while stimulating effects on respiration, energy flux parameters (ABS/RC, TR0 /RC, ET0 /RC and DI0 /RC), oxidative stress biomarkers i...
June 8, 2018: Ecotoxicology and Environmental Safety
Marie Godar, Kim Deswarte, Karl Vergote, Michael Saunders, Hans de Haard, Hamida Hammad, Christophe Blanchetot, Bart N Lambrecht
BACKGROUND: Asthma is a chronic inflammatory airway disease in which innate and adaptive immune cells act together to cause eosinophilic inflammation, goblet cell metaplasia (GCM) and bronchial hyperreactivity (BHR). In clinical trials employing biologicals against interleukin (IL)-4Rα or IL-5, only a subset of moderate-to-severe asthmatics responded favorably, suggesting that distinct pathophysiological mechanisms are at play in subgroups of patients, called endotypes. However, the effect of multiple cytokine blockade using bispecific antibodies (Ab) has not been tested...
June 8, 2018: Journal of Allergy and Clinical Immunology
Victor Defagó
Introducción: La incorporación de la Clínica y la Imagenología permiten una mejor comprensión de la Anatomía. El objetivo de este trabajo es desarrollar un prototipo rápido en material sintético que replique detalles anatómicos para ser utilizado en la docencia y el entrenamiento quirúrgico en Pediatría.Material y Método: Presentación de caso: Paciente de un año de edad con síndrome de dificultad respiratoria. En el examen endoscópico se halló una compresión traqueal distal. La angiotomografía confirmó la presencia de una malformación vascular...
October 10, 2017: Revista de la Facultad de Ciencias Médicas
Mohammadamin Tajgardoon, Michael M Wagner, Shyam Visweswara, Richard K Zimmerman
Computer simulation is the only method available for evaluating vaccination policy for rare diseases or emergency use of new vaccines. The most realistic simulation of vaccination policy is agent-based simulation (ABS) in which agents have similar socio-demographic characteristics to a population of interest. Currently, analysts use published information about vaccine efficacy (VE) as the probability that a vaccinated agent develops immunity; however, VE trials typically report only a single overall VE, or VE conditioned on one covariate (e...
2018: AMIA Summits on Translational Science Proceedings
Megumi Nukui, Hisashi Kawawaki, Takeshi Inoue, Ichiro Kuki, Shin Okazaki, Kiyoko Amo, Masao Togawa, Junichi Ishikawa, Hiroshi Rinka, Masashi Shiomi
OBJECTIVES: Acute encephalopathy has been observed with acute brain swelling (ABS) that is characterized by rapid progression to whole-brain swelling. The objective of this study was to describe the clinical characteristics of ABS. METHODS: We encountered four patients with ABS and retrospectively investigated their clinical data with a medical chart review. RESULTS: Three patients had seizure clustering or status epilepticus in the clinical course...
June 7, 2018: Brain & Development
Hun Soo Jang, Gi-Gwan Kim, Seong Hyeon Kang, Yeongmin Kim, Jung Il Yoo, Seonggwang Yoo, Kun-Kook Kim, Changsoo Jung, Heung Cho Ko
A method for transforming planar electronic devices into 3D structures under mechanically mild and stable conditions is demonstrated. This strategy involves diffusion control of acetone as a plasticizer into a spatially designed acrylonitrile butadiene styrene (ABS) framework to both laminate membrane-type electronic devices and transform them into a desired 3D shape. Optical, mechanical, and electrical analysis reveals that the plasticized region serves as a damper and even reflows to release the stress of fragile elements, for example, an Au interconnect electrode in this study, below the ultimate stress point...
June 7, 2018: Advanced Materials
Christine Lebrun, Mikael Cohen, Maria Alessandra Rosenthal-Allieri, Saskia Bresch, Sylvia Benzaken, Romain Marignier, Barbara Seitz-Polski, Michel Ticchioni
INTRODUCTION: Neuromyelitis optica spectrum disorders (NMOSD) are identified as a spectrum of inflammatory demyelinating disorders involving the brain, spinal cord and optic nerves. These disorders require early diagnosis and highly active immunosuppressive treatment. Rituximab (RTX) has demonstrated efficacy in limiting relapse in NMOSD when using several administration schedules. We questioned if the CD19+ CD27+ memory B cell count was a more reliable marker to monitor RTX administration than the RTX plasma level and CD19+ B cell count...
June 7, 2018: Neurology and Therapy
Wenli Wu, Jin Shang, Chenyang Tao, Shuai Wang, Xiaoru Hu, Shiyi Zhang, Zhanzheng Zhao
BACKGROUND: The presence of antibodies against phospholipase A2 receptor (PLA2R-Abs) in serum at diagnosis is reported to be related to the rate of spontaneous remission in patients with idiopathic membranous nephropathy (IMN); however, there is still lack of enough samples to illustrate this problem. Here, we conducted a comprehensive meta-analysis to investigate the prognostic value of PLA2R-Abs on spontaneous remission for IMN patients in the absence of immunosuppressive therapy. METHODS: A systematic search of the PubMed, EMBASE, and Cochrane Central databases was performed for relevant original articles published until October 2017...
June 2018: Medicine (Baltimore)
Erik Arntzen, Richard K Nartey, Lanny Fields
In Condition 1, adults learned the baseline relations for the three equivalence classes A1-B1-C1-D1-E1, A2-B2-C2-D2-E2, and A3-B3-C3-D3-E3. Classes contained abstract shapes in the ABS and four preliminary training groups. Each class in the PIC group contained one picture and four abstract shapes. Before class formation for four other groups, preliminary training involved establishing identity (CC) or arbitrary (CX) relations either with or without a delay. Without preliminary training, classes formed with low and high likelihoods in the ABS and PIC groups, respectively...
May 2018: Journal of the Experimental Analysis of Behavior
Sholeh Hamzehzadeh, Samira Touri
The potential of {polyethylene glycol 400 + potassium citrate} aqueous biphasic system (ABS) with ionic liquid (IL) 1-butyl-3-methylimidazolium bromide ([C4 C1 im]Br) as an adjuvant is examined for the extraction of L-phenylalanine (Phe), as a model biomolecule, at different temperatures and system compositions. The binodal curves and liquid-liquid equilibrium data were determined by the addition of 5 wt% IL to investigate its effect on phase diagrams and Phe partition coefficients. The results indicate that binodal curves of systems with and without IL are more deviated from each other with decreasing temperature...
June 7, 2018: Biotechnology Progress
Vijetha Mogilireddy, Matthieu Gras, Nicolas Schaeffer, Helena Passos, Lenka Svecova, Nicolas Papaiconomou, João A P Coutinho, Isabelle Billard
Ionic-liquid-based aqueous biphasic systems (IL-based ABS) have demonstrated exceptional performance in bioseparation processes. However, IL-based ABS are of limited interest for metal extraction as most metals are not stable in their neutral or alkaline pH conditions. In the quest for better extraction systems for metals, the development of IL-based ABS with highly acidic solutions (AcABS), induced by the mixture of a hydrophilic IL ([P44414]Cl), a mineral acid (HCl, HNO3 or H2SO4) and water, opens new possibilities...
June 7, 2018: Physical Chemistry Chemical Physics: PCCP
Tom Stargardt, Christian Eckmann, Emilio Bouza, Gian Maria Rossolini, Gian Maria Grossi
To explore the attitudes of European physicians on adherence and how treatment modalities impact adherence in complicated forms of soft skin and skin structure infections, now referred as acute bacterial skin and skin structures infections (ABSSSI). After literature review, a questionnaire was prepared. Topics focused on (1) the importance of adherence, (2) the importance of administration regimen on adherence, (3) the importance of drug selection on adherence, (4) the importance of complexity on choice of drug for treatment, (5) the role of adherence in drug resistance, and (6) the role of adherence in administration of long-acting antibiotics (ABs)...
June 6, 2018: European Journal of Clinical Microbiology & Infectious Diseases
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