keyword
https://read.qxmd.com/read/38523427/factors-associated-with-respiratory-failure-after-open-ventral-hernia-repair-an-evaluation-of-the-nsqip-database
#1
JOURNAL ARTICLE
William R Lorenz, Alexis M Holland, Brittany S Mead, Gregory T Scarola, Vedra A Augenstein, B Todd Heniford
An analysis of ACS-NSQIP open ventral hernia repair (OVHR) data (2017-2019) was performed. Respiratory failure (RF) occurred in 643 patients (1%) and not in 63,213 (99%) (nRF). Respiratory failure patients were older (63.7 vs 57 years, P < .001) and more comorbid: insulin-dependent diabetes (14.7% vs 5.8%, P < .001), COPD (19.4% vs 5.2%, P < .001), BMI (36.0 vs 32.8, P < .001), and current tobacco use (24.9% vs 17.6%, P < .001). Respiratory failure patients had greater ASA scores (ASA 3: 63...
March 24, 2024: American Surgeon
https://read.qxmd.com/read/38517625/the-changes-in-abdominal-wall-muscles-following-incisional-hernia-wall-reconstruction
#2
JOURNAL ARTICLE
Z Wang, X Wang, C Wang, Y Zhao
PURPOSE: The objective of incisional hernia surgery is to achieve the restoration of abdominal wall anatomical and physiological functions. This study aims to investigate the impact of abdominal wall reconstruction on abdominal muscle alterations by measuring the preoperative and postoperative changes in abdominal wall muscles in patients undergoing incisional hernia repair. METHODS: For patients undergoing open incisional hernia abdominal wall reconstruction, preoperative and postoperative abdominal CT scans were analyzed at a minimum of 3 months post-surgery...
March 22, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38510330/mesh-strip-repair-for-midline-ventral-hernias-a-case-series
#3
JOURNAL ARTICLE
Benjamin A Sarac, Paige Hackenberger, Jeffrey E Janis
BACKGROUND: Polypropylene mesh strip repair is a novel method of hernia closure. Currently, there is limited representation in the literature regarding both the reproducibility of this method and its outcomes. The present study sought to analyze a second institution's experience with fascial closure using the mesh strip technique with long-term follow-up. METHODS: A retrospective review of all patients undergoing abdominal wall reconstruction by the senior author was performed...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38507174/achieving-fascial-closure-with-preoperative-botulinum-toxin-injections-in-abdominal-wall-reconstruction-outcomes-from-a-high-volume-center
#4
JOURNAL ARTICLE
Lucas Fair, Steven G Leeds, Syed Harris Bokhari, Simon Esteva, Tanner Mathews, Gerald O Ogola, Marc A Ward, Bola Aladegbami
Preoperative injection of Botulinum Toxin A (Botox) has been described as an adjunctive therapy to facilitate fascial closure of large hernia defects in abdominal wall reconstruction (AWR). The purpose of this study was to evaluate the impact of Botox injections on fascial closure and overall outcomes to further validate its role in AWR. A prospectively maintained database was retrospectively reviewed to identify all patients undergoing AWR at our institution between January 2014 and March 2022. Patients who did and did not receive preoperative Botox injections were analyzed and compared...
March 20, 2024: Updates in Surgery
https://read.qxmd.com/read/38505988/diverse-thermal-desorption-combined-with-self-aspirating-corona-discharge-ionization-for-direct-mass-spectrometry-analysis-of-complex-samples
#5
JOURNAL ARTICLE
Qinhao Shi, Xiaohua Yu, Shuang Sun, Weilong Wu, Wenyan Shi, Quan Yu
The thermal desorption (TD) technique is widely employed in modern mass spectrometry to facilitate the detection of non-volatile analytes. In this study, we developed a compact TD device based on a small resistance wire and coupled it with a self-aspirating corona discharge ionization (CDI) source to conduct direct MS analysis of various liquid and solid samples. Due to its small size and low heat capacity, the temperature of the TD module can be flexibly and rapidly modulated by controlling the power sequence...
March 20, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38491173/prognostic-factors-of-renal-cell-cancer-in-elderly-patients-a-population-based-cohort-study
#6
JOURNAL ARTICLE
Heini Pajunen, Thea Veitonmäki, Heini Huhtala, Jussi Nikkola, Antti Pöyhönen, Teemu Murtola
Mortality in renal cell cancer (RCC) is high in the elderly population. Comorbidities have a greater impact on overall prognosis of RCC among elderly patients than in younger patients. All new RCC cases were collected in people over 74 years of age between 1995 and 2018 from the Finnish cancer registry. The comorbidities were identified from the Care Registry for Healthcare. Charlson Comorbidity Index (CCI) was used to evaluate the risk of death based on comorbidities. The overall risk of death was analyzed using the Cox regression model...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38480404/geometric-morphometrics-of-the-wings-of-amazonian-species-of-melipona-illiger-1806-hymenoptera-apidae
#7
JOURNAL ARTICLE
Juliana Stephanie Galaschi-Teixeira, Jamille Costa Veiga, Valria DA Cunha Tavares, Vera Lucia Imperatriz-Fonseca
Identifying and classifying species of stingless Neotropical bees is not a trivial task and requires the help of taxonomists and substantial study and training time. Also, there is a lack of taxonomically useful characters to differentiate among the megadiverse Neotropical group of stingless bees, and to recognize variation. Based on that, we have been testing alternatives to a character-based, efficient taxonomic determination of stingless bees, and herein we performed exploratory analyses of wing shape variation using geometric morphometrics...
January 25, 2024: Zootaxa
https://read.qxmd.com/read/38474891/discussion-on-the-discreteness-of-the-attenuation-parameters-of-the-peak-particle-velocity-induced-by-blasting
#8
JOURNAL ARTICLE
Zhaowei Yang, Yingguo Hu, Meishan Liu, Peng Li, Erlei Yao, Chenyang Ma
The research on the attenuation law of blasting vibration has become the foundation and precondition of the effective control of blasting vibration damage. Aiming at the characteristics of low frequency, low velocity, and strong amplitude of the R wave, an improved wave component separation method based on R wave suppression is proposed. Combined with the measured vibration signals of a field test, the attenuation parameters of different types of waves in the propagation process of blasting seismic waves are studied...
February 20, 2024: Sensors
https://read.qxmd.com/read/38467335/identification-of-structural-origins-of-complex-charge-heterogeneity-in-therapeutic-ace2fc-fusion-protein-facilitated-by-free-flow-isoelectric-focusing
#9
JOURNAL ARTICLE
Lingyu Wang, Hai Wu, Ting Cao, Hongyang Li, Pengcheng Shen, Lihong Lu, Zhongli Zhang
Fc Fusion protein represents a versatile molecular platform with considerable potential as protein therapeutics of which the charge heterogeneity should be well characterized according to regulatory guidelines. Angiotensin-converting enzyme 2 Fc fusion protein (ACE2Fc) has been investigated as a potential neutralizing agent to various coronaviruses, including the lingering SARS-CoV-2, as this coronavirus must bind to ACE2 to allow for its entry into host cells. ACE2Fc, an investigational new drug developed by Henlius (Shanghai China), has passed the Phase I clinical trial, but its huge amount of charge isoforms and complicated charge heterogeneity posed a challenge to charge variant investigation in pharmaceutical development...
March 9, 2024: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/38429399/maximizing-mesh-mileage-evaluating-the-long-term-performance-of-a-novel-hybrid-mesh-for-ventral-hernia-repair
#10
JOURNAL ARTICLE
G J Spurzem, R C Broderick, J Z Li, B J Sandler, S Horgan, G R Jacobsen
PURPOSE: The objective of this study is to evaluate the safety and long-term outcomes of GORE Synecor™ in ventral hernia repair (VHR). METHODS: This retrospective, single-center case review analyzed outcomes in patients who underwent VHR with Synecor from May 2016 to December 2022. Primary outcomes were hernia recurrence and mesh infection rates. Secondary outcomes were 30-day morbidity, 30-day mortality, 30-day readmission, re-operation, surgical-site infection (SSI) and occurrence (SSO) rates, and occurrences requiring intervention (SSOI)...
March 1, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38427113/outcomes-of-complex-abdominal-wall-reconstruction-in-patients-with-connective-tissue-disorders-a-single-center-experience
#11
JOURNAL ARTICLE
N Messer, A S Prabhu, B T Miller, D M Krpata, L R A Beffa, S E Phillips, C C Petro, S M Maskal, R C Ellis, S Figueiredo, A Fafaj, M J Rosen
INTRODUCTION: Individuals diagnosed with connective tissue disorders (CTD) are known to be predisposed to incisional hernia formation. However, there is a scarcity of data on outcomes for these patients undergoing hernia repair. We sought to describe our outcomes in performing abdominal wall reconstructions in these complex patients. METHODS: Adult patients with CTD undergoing open, elective, posterior component separation with permanent synthetic mesh at our institution from January 2018 to October 2022 were queried from a prospectively collected database in the Abdominal Core Health Quality Collaborative...
March 1, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38413051/projection-based-two-sample-inference-for-sparsely-observed-multivariate-functional-data
#12
JOURNAL ARTICLE
Salil Koner, Sheng Luo
Modern longitudinal studies collect multiple outcomes as the primary endpoints to understand the complex dynamics of the diseases. Oftentimes, especially in clinical trials, the joint variation among the multidimensional responses plays a significant role in assessing the differential characteristics between two or more groups, rather than drawing inferences based on a single outcome. We develop a projection-based two-sample significance test to identify the population-level difference between the multivariate profiles observed under a sparse longitudinal design...
February 27, 2024: Biostatistics
https://read.qxmd.com/read/38381782/multiscale-flow-for-robust-and-optimal-cosmological-analysis
#13
JOURNAL ARTICLE
Biwei Dai, Uroš Seljak
We propose Multiscale Flow, a generative Normalizing Flow that creates samples and models the field-level likelihood of two-dimensional cosmological data such as weak lensing. Multiscale Flow uses hierarchical decomposition of cosmological fields via a wavelet basis and then models different wavelet components separately as Normalizing Flows. The log-likelihood of the original cosmological field can be recovered by summing over the log-likelihood of each wavelet term. This decomposition allows us to separate the information from different scales and identify distribution shifts in the data such as unknown scale-dependent systematics...
February 27, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38372372/abdominal-wall-tension-and-early-outcomes-after-posterior-component-separation-with-transversus-abdominis-release-does-a-tension-free-closure-really-matter
#14
JOURNAL ARTICLE
Benjamin T Miller, Ryan Ellis, Sara M Maskal, Clayton C Petro, David M Krpata, Ajita S Prabhu, Lucas Ra Beffa, Chao Tu, Michael J Rosen
BACKGROUND: Ventral hernias result in fibrosis of the lateral abdominal wall muscles, increasing tension on fascial closure. Little is known about the effect of abdominal wall tension on outcomes after abdominal wall reconstruction. We aimed to identify an association between abdominal wall tension and early postoperative outcomes in patients who underwent posterior components separation (PCS) with transversus abdominis release (TAR). STUDY DESIGN: Using a proprietary, sterilizable tensiometer, the tension needed to bring the anterior fascial elements to the midline of the abdominal wall during PCS with TAR were recorded...
February 19, 2024: Journal of the American College of Surgeons
https://read.qxmd.com/read/38367096/comparison-of-open-and-endoscopic-posterior-component-separation-with-transversus-abdominis-release-a-propensity-score-matched-study
#15
JOURNAL ARTICLE
G B Ivakhov, A A Kalinina, A V Andriyashkin, S M Titkova, K M Loban, N S Glagolev, A V Sazhin
BACKGROUND: Posterior component separation with transversus abdominis release (TAR) is considered to be the optimal technique for large incisional ventral hernia repair. Endoscopic TAR (eTAR) that gets all the benefits of minimally invasive surgery (MIS) gives a possibility to enhance results of the treatment. The aim of our study was to make the comparison between open and endoscopic TAR procedures with an emphasis on frequency and severity of postoperative complications in comparable groups...
February 17, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38358365/experimental-observation-of-a-peculiar-effect-in-electron-paramagnetic-resonance-spectra-for-nitroxides-undergoing-fast-spin-exchange-emission
#16
JOURNAL ARTICLE
Barney L Bales, Miroslav Peric, Robert N Schwartz
We report the experimental observation of an EPR spectral manifestation of spin exchange frequencies, ω ex , larger than the 15 N hyperfine separation, A 0 , predicted 50 years ago but previously not observed. For spectra with ω ex / γA 0 < 1, where γ is the gyromagnetic ratio of the electron, the spectrum consists of two "normal" spin modes each with one absorption and one dispersion component separated by A abs < A 0 . A abs decreases with ω ex . In stark contrast, when ω ex / γA 0 > 1, the spectrum consists of two absorption spin modes, one of which is negative (emissive)...
February 15, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38342140/use-of-botulinum-toxin-type-a-in-the-prehabilitation-of-abdominal-wall-musculature-for-hernia-repair-a-consensus-proposal
#17
JOURNAL ARTICLE
Pous Serrano Salvador, Bueno Lledó José, García Pastor Providencia, Carreño Saenz Omar, Pareja Ibars Victoria, Bonafé Diana Santiago, Gea Moreno Alba Maria, Jesús Martínez-Hoed
The prehabilitation of the abdominal wall through the infiltration of botulinum toxin type A, which induces temporary chemical denervation ("chemical component separation") in the lateral abdominal musculature, is a common practice in units specialized in abdominal wall surgery. However, its use for this indication is currently off-label. The main objective of this article is to describe a consensus proposal regarding indications, contraindications, dosages employed, potential side effects, administration method, and measurement of possible outcomes...
February 9, 2024: Cirugia española
https://read.qxmd.com/read/38286880/outcomes-of-posterior-component-separation-with-transversus-abdominis-release-for-repair-of-abdominally-based-breast-reconstruction-donor-site-hernias
#18
JOURNAL ARTICLE
C M McLaughlin, K C Montelione, C Tu, X Candela, E Pauli, A S Prabhu, D M Krpata, C C Petro, S Rosenblatt, M J Rosen, C M Horne
PURPOSE: Abdominally based autologous breast reconstruction (ABABR) is common after mastectomy, but carries a risk of complex abdominal wall hernias. We report experience with posterior component separation (PCS) and transversus abdominis release (TAR) with permanent synthetic mesh repair of ABABR-related hernias. METHODS: Patients at Cleveland Clinic Foundation and Penn State Health were identified retrospectively. Outcomes included postoperative complications, hernia recurrence, and patient-reported outcomes (PROs): Hernia Recurrence Inventory, HerQLes Summary Score, Patient-Reported Outcome Measurement Information System (PROMIS) Pain Intensity 3a Survey, and the Decision Regret Scale (DRS)...
January 29, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38284557/chir-98014-a-gsk-3%C3%AE-inhibitor-protects-against-triptolide-lipopolysaccharide-induced-hepatotoxicity-by-mitochondria-dependent-apoptosis-inhibition
#19
JOURNAL ARTICLE
Shaoyun Zhou, Ruohan Cheng, Yue Zhang, Yihan Jiang, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Triptolide (TP) is a remarkable anti-inflammatory and immunosuppressive component separated from Tripterygium wilfordii Hook. F. However, its hepatotoxicity limits its application in the clinical. Our group has proposed a new perspective on TP-induced hepatotoxicity, in which TP enhances liver hypersensitivity upon lipopolysaccharide (LPS) stimulation. Because the cause of the disease is unknown, there is currently no uniform treatment available. In this study, we attempted to determine whether the GSK-3β-JNK pathway affects liver damage and its regulatory mechanism in response to TP/LPS costimulation...
January 29, 2024: Chemical Research in Toxicology
https://read.qxmd.com/read/38279012/comprehensive-metabolome-characterization-and-comparison-between-two-sources-of-dragon-s-blood-by-integrating-liquid-chromatography-mass-spectrometry-and-chemometrics
#20
JOURNAL ARTICLE
Jia Lou, Xiao-Yan Xu, Bei Xu, Hong-da Wang, Xue Li, He Sun, Xin-Yuan Zheng, Jun Zhou, Ya-Dan Zou, Hong-Hua Wu, Yue-Fei Wang, Wen-Zhi Yang
Dragon's Blood (DB) serves as a precious Chinese medicine facilitating blood circulation and stasis dispersion. Daemonorops draco (D. draco; Qi-Lin-Jie) and Dracaena cochinchinensis (D. cochinchinenesis; Long-Xue-Jie) are two reputable plant sources for preparing DB. This work was designed to comprehensively characterize and compare the metabolome differences between D. draco and D. cochinchinenesis, by integrating liquid chromatography/mass spectrometry and untargeted metabolomics analysis. Offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (2D-LC/IM-QTOF-MS), by utilizing a powerful hybrid scan approach, was elaborated for multicomponent characterization...
January 27, 2024: Analytical and Bioanalytical Chemistry
keyword
keyword
31293
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.