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Early onset sepsis

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https://www.readbyqxmd.com/read/29928136/the-diagnostic-utility-of-procalcitonin-interleukin-6-and-interleukin-8-and-hyaluronic-acid-in-the-norwegian-consensus-definition-for-early-onset-neonatal-sepsis-eons-retraction
#1
(no author information available yet)
[This retracts the article on p. 359 in vol. 11, PMID: 29563816.].
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29912095/combined-biomarkers-predict-acute-mortality-among-critically-ill-patients-with-suspected-sepsis
#2
Brendan J Kelly, Ebbing Lautenbach, Irving Nachamkin, Susan E Coffin, Jeffrey S Gerber, Barry D Fuchs, Charles Garrigan, Xiaoyan Han, Warren B Bilker, Jacqueleen Wise, Pam Tolomeo, Jennifer H Han
OBJECTIVES: Sepsis is associated with high early and total in-hospital mortality. Despite recent revisions in the diagnostic criteria for sepsis that sought to improve predictive validity for mortality, it remains difficult to identify patients at greatest risk of death. We compared the utility of nine biomarkers to predict mortality in subjects with clinically suspected bacterial sepsis. DESIGN: Cohort study. SETTING: The medical and surgical ICUs at an academic medical center...
July 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29907848/cerebral-blood-flow-and-serum-neuron-specific-enolase-in-early-onset-neonatal-sepsis
#3
Mohammed S El Shimy, Nehal M El-Raggal, Rania A El-Farrash, Hebatallah A Shaaban, Hanan E Mohamed, Noha M Barakat, Ahmed S Farag, Abeer K El Zohiery, Menat Allah A Shaaban, Dina H Salama
BACKGROUND AND OBJECTIVES: Sepsis leads to systemic inflammatory response with cerebral blood flow (CBF) alteration and blood-brain barrier disruption that contribute to sepsis-associated encephalopathy (SAE). We aimed to evaluate cord blood neuron-specific enolase (cNSE) and CBF in early-onset neonatal sepsis (EONS) as predictors of SAE and to define short-term neurodevelopmental outcomes among survivors. METHODS: cNSE was measured in 200 neonates with antenatal risk factors for EONS, stratified into two groups: sepsis (n = 96) and no-sepsis (n = 104)...
May 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29898454/neonates-at-risk-of-early-onset-sepsis-which-is-the-best-approach
#4
Alberto Berardi, Caterina Spada, Maria Grazia Capretti, Matilde Ciccia, Maria Rita Pulvirenti, Martina Vezzosi, Fabrizio Sandri
No abstract text is available yet for this article.
June 13, 2018: Neonatology
https://www.readbyqxmd.com/read/29895470/validity-of-biomarkers-in-screening-for-neonatal-sepsis-a-single-center-hospital-based-study
#5
Nagwan I Rashwan, Mohammed H Hassan, Zeinab M Mohey El-Deen, Ahmed El-Abd Ahmed
BACKGROUND: The diagnosis of neonatal sepsis still considered to be a challenge for both clinicians and the laboratory due to the non-specific clinical presentations. The present study aimed to compare and assess the diagnostic & prognostic values of C-reactive protein (CRP), high sensitivity CRP (hsCRP), presepsin, interleukin-6 (IL-6) and procalcitonin (PCT) in neonatal sepsis separately and in combination. METHODS: This hospital-based cross-sectional study has been conducted on 168 neonates recruited from the neonatal intensive care unit (NICU) of Qena University Hospitals, Upper Egypt...
May 12, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29888926/features-and-outcomes-of-immunoglobulin-therapy-in-patients-with-good-syndrome-at-thailand-s-largest-tertiary-referral-hospital
#6
Torpong Thongngarm, Adhiratha Boonyasiri, Panitan Pradubpongsa, Nattaporn Tesavibul, Tauangtham Anekpuritanang, Piyawut Kreetapirom, Mongkhon Sompornrattanaphan
BACKGROUND: Good syndrome (GS) is an adult-onset immunodeficiency characterized by coexisting thymoma and hypogammaglobulinemia. Clinical course after treatment with intravenous immunoglobulin (IVIg) has rarely been reported. OBJECTIVE: To investigate and report the clinical course and outcomes of GS patients after treatment with IVIg at Thailand's largest national tertiary referral hospital METHODS: This retrospective chart review included patients diagnosed with GS and treated with IVIg during the 1 January 2005 to 31 December 2015 study period...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29888426/differential-response-to-renal-replacement-therapy-in-neonatal-onset-inborn-errors-of-metabolism
#7
Francesco Porta, Licia Peruzzi, Roberto Bonaudo, Silvia Pieretti, Marta Busso, Enrico Cocchi, Alessandra Conio, Veronica Pagliardini, Marco Spada
Severe urea cycle defects (UCDs), organic acidemias (OAs), and maple syrup urine disease (MSUD) are life-threatening disorders presenting in the first days of life. Renal replacement therapy (RRT) is an emergency option in affected newborns, mostly performed as ultima ratio. We report our 10-year experience using emergency RRT in newborns with UCDs, OAs, and MSUD. Twelve newborns (8 with UCDs, 2 with methylmalonic acidemia, and 2 with MSUD) underwent emergency RRT. The overall survival rate to RRT was 58.3%...
June 10, 2018: Nephrology
https://www.readbyqxmd.com/read/29886794/mean-platelet-volume-in-preterm-a-predictor-of-early-onset-neonatal-sepsis
#8
Hebatallah A Shaaban, Nesma Safwat
BACKGROUND: Early onset sepsis (EOS) is potentially life-threatening problem especially in preterm. EOS diagnosis is challenging due to its nonspecific signs and laboratory tests. Mean platelet volume (MPV) has been used as predictor of many inflammatory diseases. OBJECTIVES: To assess the correlation between serial MPV measurement and EOS occurrence in preterm infants and to determine MPV effectiveness in combination with C reactive protein (CRP) to diagnose EOS and mortality prediction...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29875143/the-microbiome-and-metabolome-of-preterm-infant-stool-are-personalized-and-not-driven-by-health-outcomes-including-necrotizing-enterocolitis-and-late-onset-sepsis
#9
Stephen Wandro, Stephanie Osborne, Claudia Enriquez, Christine Bixby, Antonio Arrieta, Katrine Whiteson
The assembly and development of the gut microbiome in infants have important consequences for immediate and long-term health. Preterm infants represent an abnormal case for bacterial colonization because of early exposure to bacteria and frequent use of antibiotics. To better understand the assembly of the gut microbiota in preterm infants, fecal samples were collected from 32 very low birth weight preterm infants over the first 6 weeks of life. Infant health outcomes included health, late-onset sepsis, and necrotizing enterocolitis (NEC)...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29795204/neonatal-sepsis-leads-to-early-rise-of-rare-serum-bile-acid-tauro-omega-muricholic-acid-tomca
#10
Evelyn Zöhrer, Katharina Meinel, Günter Fauler, Victor Aguiriano Moser, Theresa Greimel, Joachim Zobl, Axel Schlagenhauf, Jörg Jahnel
BACKGROUND: We investigated 'rare' bile acids (BA) as potential markers in septic neonates. METHODS: 'Rare' (C-6 hydroxylated BA) and 'classical' BA were determined in 102 neonates using high-performance liquid chromatography-high-resolution mass spectrometry (HPLC-HRMS). Four groups according to maturity (full term, FT vs. preterm, PT) and septic status (early-onset neonatal sepsis, EOS vs. CTR; non-septic controls) were formed: FT-CTR; (n = 47), PT-CTR (n = 22), FT-EOS (n = 20), PT-EOS (n = 13)...
May 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29792059/pitfalls-in-the-diagnosis-of-meningitis-in-neonates-and-young-infants-the-role-of-lumbar-puncture
#11
Luca Bedetti, Lucia Marrozzini, Alessandro Baraldi, Elisabetta Spezia, Lorenzo Iughetti, Laura Lucaccioni, Alberto Berardi
Meningitis occurs frequently in neonates and can lead to a number of acute, severe complications and long-term disabilities. An early diagnosis of neonatal meningitis is essential to reduce mortality and to improve outcomes. Initial clinical signs of meningitis are often subtle and frequently overlap with those of sepsis, and current haematologic tests do not distinguish sepsis from meningitis. Thus, lumbar puncture remains the gold standard for the diagnosis of meningitis in infants, and this procedure is recommended in clinical guidelines...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29791315/incidence-of-early-onset-sepsis-in-infants-born-to-women-with-clinical-chorioamnionitis
#12
Tara M Randis, Madeline Murguia Rice, Leslie Myatt, Alan T N Tita, Kenneth J Leveno, Uma M Reddy, Michael W Varner, John M Thorp, Brian M Mercer, Mara J Dinsmoor, Susan M Ramin, Marshall W Carpenter, Philip Samuels, Anthony Sciscione, Jorge E Tolosa, George Saade, Yoram Sorokin
OBJECTIVE: To determine the frequency of sepsis and other adverse neonatal outcomes in women with a clinical diagnosis of chorioamnionitis. METHODS: We performed a secondary analysis of a multi-center placebo-controlled trial of vitamins C/E to prevent preeclampsia in low risk nulliparous women. Clinical chorioamnionitis was defined as either the "clinical diagnosis" of chorioamnionitis or antibiotic administration during labor because of an elevated temperature or uterine tenderness in the absence of another cause...
May 23, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29788474/umbilical-cord-blood-transplantation-corrects-very-early-onset-inflammatory-bowel-disease-in-chinese-patients-with-il10ra-associated-immune-deficiency
#13
Kaiyue Peng, Xiaowen Qian, Zhiheng Huang, Junping Lu, Yuhuan Wang, Ying Zhou, Huijun Wang, Bingbing Wu, Ying Wang, Lingli Chen, Xiaowen Zhai, Ying Huang
Background: Hematopoietic stem cell transplantation is considered the only curative therapy for very early-onset inflammatory bowel disease with specific immune defects, such as interleukin-10 receptor deficiency. We performed reduced-intensity conditioning before umbilical cord blood transplantation in patients with interleukin-10 receptor-A deficiency. Methods: We enrolled 9 very early-onset inflammatory bowel disease patients with typical manifestations. We diagnosed the patients with interleukin-10 receptor-A deficiency by whole-exome sequencing...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29786145/pilot-study-demonstrates-that-placental-histology-can-provide-an-additional-tool-for-diagnosing-early-onset-neonatal-sepsis
#14
J M A Ykema, E J D'Haens, M Havenith, J van Eyck, R A van Lingen, M A C Hemels
AIM: We explored whether placental histology could help to diagnose early-onset neonatal sepsis (EONS), guide clinical decision-making 48 hours after birth and reduce antibiotic use. METHODS: This study comprised 109 infants born at less than 32 weeks of gestation, who were admitted to the neonatal intensive care unit of Isala, Zwolle, The Netherlands, between January 2013 and December 2013. EONS was defined as clinical symptoms plus raised serial C-reactive protein >10 mg/L and a positive (proven EONS) or a negative (suspected EONS) blood culture...
May 22, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29781085/effect-of-hypothermia-treatment-on-gentamicin-pharmacokinetics-in-neonates-with-hypoxic-ischaemic-encephalopathy-a-systematic-review-and-meta-analysis
#15
REVIEW
D W Choi, J H Park, S Y Lee, S H An
WHAT IS KNOWN AND OBJECTIVE: Hypothermia is the current standard therapy for asphyxiated neonates with hypoxic-ischaemic encephalopathy (HIE). Gentamicin is used for the empirical treatment of early-onset neonatal sepsis. We investigated the influence of hypothermia treatment on gentamicin pharmacokinetics and suggested the appropriate dosing recommendations for gentamicin in neonates with HIE receiving hypothermia treatment. METHODS: We searched studies published until February 2017 in MEDLINE using PubMed, EMBASE and the Cochrane Library...
May 20, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29754879/congenital-pyloric-atresia-nine-new-cases-single-center-experience-of-the-long-term-follow-up-and-the-lessons-learnt-over-a-decade
#16
Monal Kansra, V Shankar Raman, Kamal Kishore, Sanat Khanna, Bipin Puri, Abhishek Sharma
BACKGROUND: Congenital pyloric atresia (CPA) is a rare anomaly with an incidence of 1 in 100,000 live births. Depending on the type of anomaly patients can either present in the neonatal period or later in life with subtle nonspecific signs and symptoms. We present our institute's experience in handling these cases over the last decade and highlight lessons learnt. MATERIALS AND METHODS: We retrospectively reviewed records of patients diagnosed with CPA and managed at our centre between Jan 2006 to June 2016...
April 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29750801/streptococcus-agalactiae-carriage-among-pregnant-women-living-in-rio-de-janeiro-brazil-over-a-period-of-eight-years
#17
Ana Caroline N Botelho, Juliana G Oliveira, Andreia P Damasco, Késia T B Santos, Ana Flávia M Ferreira, Gabriel T Rocha, Penélope S Marinho, Rita B G Bornia, Tatiana C A Pinto, Marco A Américo, Sergio E L Fracalanzza, Lúcia M Teixeira
Group B Streptococcus (GBS) carriage by pregnant women is the primary risk factor for early-onset GBS neonatal sepsis. Intrapartum antibiotic prophylaxis (IAP) can prevent this transmission route, and two main approaches are recommended to base the selection of pregnant women to be submitted to IAP: the risk-based and the culture-based strategies. In Brazil, compliance to such recommendations is poor, and not much is known about GBS carriage. In the present study, 3,647 pregnant women living in Rio de Janeiro State, Brazil, were screened for GBS anogenital colonization, over a period of 8 years (2008-2015)...
2018: PloS One
https://www.readbyqxmd.com/read/29705932/neonatal-thrombocytopenia-causes-and-outcomes-following-platelet-transfusions
#18
Elisabeth Resch, Olesia Hinkas, Berndt Urlesberger, Bernhard Resch
We evaluated the causes for neonatal thrombocytopenia (NT), the duration of NT, and the indications of platelet transfusions (PT) by means of a retrospective cohort study over a 23-year period. Neonates with NT were identified via ICD-10 code D69.6. Of 371 neonates (1.8/1000 live births) with NT, the majority (312; 84.1%) had early onset thrombocytopenia, and 282 (76%) were preterm born. The most frequent causes for NT were early and late onset sepsis and asphyxia. The mean duration of thrombocytopenia was 10...
July 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29703848/should-empiric-antibiotic-therapy-be-withheld-when-aetiology-of-preterm-birth-is-non-infectious-a-protocol-for-a-systematic-review
#19
Joanna Seliga-Siwecka, Mohammed Toseef Ansari, Judy Aschner, Margaret Sampson, Justyna Romańska
INTRODUCTION: Preterm birth (PTB) at <37 weeks of gestation is the leading cause of perinatal morbidity and mortality in developed countries. The traditional approach has been based on the assumption that PTB is primarily a result of intrauterine infection, which triggers preterm labour and puts the newborn at risk of early onset sepsis (EOS). We are currently experiencing a rise in prematurity that results from maternal and fetal diseases unrelated to infection. We have designed a systematic review to assess whether chemoprophylaxis should be withheld when the aetiology of preterm birth is non-infectious...
April 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29691444/adaptive-response-of-neonatal-sepsis-derived-group-b-streptococcus-to-bilirubin
#20
Richard Hansen, Sophie Gibson, Eduardo De Paiva Alves, Mark Goddard, Andrew MacLaren, Anne Marie Karcher, Susan Berry, Elaina S R Collie-Duguid, Emad El-Omar, Mike Munro, Georgina L Hold
Hyperbilirubinemia is so common in newborns as to be termed physiological. The most common bacteria involved in early-onset neonatal sepsis are Streptococcus agalactiae, commonly called Group B Streptococcus (GBS). Whilst previous studies show bilirubin has antioxidant properties and is beneficial in endotoxic shock, little thought has been given to whether bilirubin might have antibacterial properties. In this study, we performed a transcriptomic and proteomic assessment of GBS cultured in the presence/absence of bilirubin...
April 24, 2018: Scientific Reports
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