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Crystal arthropathy

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https://www.readbyqxmd.com/read/29672810/advanced-imaging-in-the-diagnosis-of-gout-and-other-crystal-arthropathies
#1
James Teh, Fiona McQueen, Iris Eshed, Athena Plagou, Andrea Klauser
In recent years significant advances have been made in imaging techniques. Dual-energy computed tomography has revolutionized the ability to detect and quantify gout. The key ultrasound features of gout have been defined. Magnetic resonance imaging is an excellent modality for demonstrating the extent and severity of crystal arthropathies, but the findings may be nonspecific. This article summarizes the use of advanced imaging techniques in the diagnosis and assessment of gout and other crystal arthropathies...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29547895/gout-state-of-the-art-after-a-decade-of-developments
#2
Tristan Pascart, Frédéric Lioté
This review article summarizes the relevant English literature on gout from 2010 through April 2017. It emphasizes that the current epidemiology of gout indicates a rising prevalence worldwide, not only in Western countries but also in Southeast Asia, in close relationship with the obesity and metabolic syndrome epidemics. New pathogenic mechanisms of chronic hyperuricaemia focus on the gut (microbiota, ABCG2 expression) after the kidney. Cardiovascular and renal comorbidities are the key points to consider in terms of management...
March 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29531789/knee-joint-synovitis-study-of-correlations-and-diagnostic-performances-of-ultrasonography-compared-with-histopathology
#3
Aurélie Najm, Carl Orr, Lorna Gallagher, Monika Biniecka, Emeline Gaigneux, Benoit Le Goff, Ursula Fearon, Douglas J Veale
Objectives: Ultrasonography (US) is a fast, available and low-cost imaging tool used for detecting knee synovitis. Our aims were to assess the relationship between US and histology findings in appraising levels of inflammation and vascularity in the knee joint in subjects with inflammatory arthropathies; to determine whether differences exist in the appraisal between varying knee compartments and to compare US performances compared with gold standard histology for knee synovitis detection...
2018: RMD Open
https://www.readbyqxmd.com/read/29524120/a-beacon-in-the-dark-canakinumab-a-new-therapeutic-perspective-in-chronic-tophaceous-gout
#4
Daniela Marotto, Antonella De Santis, Donatella Chessa, Davide Firinu, Stefano Del Giacco
Gout is the most common form of arthritis in adults. It is often associated with other comorbidities, which contraindicate the use of conventional therapies. The discovery of the role of interleukin-1β (IL-1β) in orchestrating the monosodium urate crystal-induced inflammatory response offered new therapeutic prospects to refractory patients, or to those in whom standard therapies are contraindicated. This paper describes a clinical case of a 65-year-old man with chronic tophaceous gouty arthropathy and subintrant flares, who had comorbidities contraindicating the use of conventional gout therapies-to which he did not respond-who was treated with canakinumab, a monoclonal selective inhibitor of IL-1β...
March 9, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29465359/socio-economic-inequalities-in-occurrence-and-health-care-costs-in-rheumatic-and-musculoskeletal-diseases-results-from-a-spanish-population-based-study-including-1-9-million-persons
#5
Polina Putrik, Sofia Ramiro, Juan F Orueta, Andras Keszei, Edurne Alonso Moran, Roberto Nuño Solinis, Annelies Boonen
OBJECTIVES: To explore and compare the impact of socio-economic deprivation on the occurrence of the major rheumatic and musculoskeletal diseases (RMDs) and health care costs. METHODS: Data on diagnoses, socio-demographics and health care costs of the entire adult population of the Basque Country (Spain) was used. Area deprivation index included five categories (1 to 5 (most deprived)). Cost categories included primary and specialist care, emergency room, hospitalisations, and drug prescriptions...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29194109/crystalline-arthropathy-and-bone-health
#6
Ian Chang, David Gazeley
PURPOSE OF REVIEW: The purpose of this review is to provide insight on the proposed association between crystal arthritis and bone health. Crystal arthritis is the most common type of inflammatory arthritis, and fractures contribute to significant morbidity and mortality, therefore, the relationship between the two is of clinical importance. RECENT FINDINGS: There have been variable findings regarding hyperuricemia, low bone density and risk of fracture. A recent systematic review and meta-analysis of available literature showed a correlation between increased serum uric acid and lower risk of fracture...
March 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29183711/mixed-crystal-arthropathy-of-the-wrist-the-contribution-of-imaging-in-the-diagnostic-approach
#7
Nikita Khmelinskii, Joaquim Polido-Pereira
No abstract text is available yet for this article.
November 25, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28886220/anti-inflammatory-effects-of-polyphenols-in-arthritis
#8
REVIEW
Francesca Oliviero, Anna Scanu, Yessica Zamudio-Cuevas, Leonardo Punzi, Paolo Spinella
Polyphenols have been extensively investigated with regard to their antioxidant, anti-inflammatory, and immunomodulant properties in many inflammatory chronic conditions. The aim of this review is to summarise how these compounds can modulate the inflammatory pathways which characterise the most prevalent arthropathies including osteoarthritis, rheumatoid arthritis and crystal-induced arthritis. Among polyphenols, epigallocatechin gallate, carnosol, hydroxytyrosol, curcumin, resveratrol, kaempferol and genistein have been the most widely investigated in arthritis...
September 8, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28774457/conventional-radiology-in-crystal-arthritis-gout-calcium-pyrophosphate-deposition-and-basic-calcium-phosphate-crystals
#9
REVIEW
Thibaut Jacques, Paul Michelin, Sammy Badr, Michelangelo Nasuto, Guillaume Lefebvre, Neal Larkman, Anne Cotten
This article reviews the main radiographic features of crystal deposition diseases. Gout is linked to monosodium urate crystals. Classic radiographic features include subcutaneous tophi, large and well-circumscribed paraarticular bone erosions, and exuberant bone hyperostosis. Calcium pyrophosphate deposition (CPPD) can involve numerous structures, such as hyaline cartilages, fibrocartilages, or tendons. CPPD arthropathy involves joints usually spared by osteoarthritis. Basic calcium phosphate deposits are periarticular or intraarticular...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28692451/the-value-of-musculoskeletal-ultrasound-in-geriatric-care-and-rehabilitation
#10
Büşra Can, Murat Kara, Özgür Kara, Zekeriya Ülger, Walter R Frontera, Levent Özçakar
The WHO reports that one of the major chronic conditions affecting the elderly worldwide is musculoskeletal disorders that are associated with long-term pain and disability. Considering the healthcare needs of the elderly (i.e. comprehensive, accessible, efficient) and the advantages of ultrasound (US) use (patient-friendly, convenient, cost-effective, and does not require exposure to radiation or magnetic fields), there seems to be a 'gap' in the actual clinical practice. In this paper, we aimed to highlight the potential value of US imaging in the management of the elderly with a wide spectrum of musculoskeletal conditions (degenerative/rheumatic joint diseases, falls/trauma, nursing care, peripheral nerve problems, sarcopenia, and interventions)...
December 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28588495/a-brief-history-of-il-1-and-il-1-ra-in-rheumatology
#11
Jean-Michel Dayer, Francesca Oliviero, Leonardo Punzi
The history of what, in 1979, was called interleukin-1 (IL-1), orchestrator of leukocyte inter-communication, began many years before then, initially by the observation of fever induction via the endogenous pyrogen (EP) (1974) and then in rheumatology on the role in tissue destruction in rheumatoid diseases via the induction of collagenase and PGE2 in human synovial cells by a mononuclear cell factor (MCF) (1977). Since then, the family has exploded to presently 11 members as well as many membrane-bound and soluble receptor forms...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28459425/milwaukee-shoulder-syndrome
#12
Hale Ersoy, Stephen J Pomeranz
Milwaukee shoulder syndrome (MSS) is a rare, rapidly destructive arthropathy associated with calcium hydroxyapatite crystal deposition. This condition is a combination of rotator cuff tear, osteoarthritic changes, noninflammatory joint effusion containing crystals, synovial hyperplasia, cartilage and subchondral bone destruction, and multiple osteochondral loose bodies. This article discusses pathophysiology, clinical presentation, differential considerations, and magnetic resonance imaging findings of MSS.
December 0: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/28457098/crystal-induced-arthropathy-in-elderly-patients-hospitalized-for-acute-conditions
#13
Andrew Villion, Zeev Arinzon, Jacob Feldman, Oded Kimchi, Yitshal Berner
BACKGROUND: Arthritis and arthralgia are painful symptoms experienced by many elderly patients during hospitalization. Crystal-induced arthritis (CIA) is one of the most common causes of arthritis worldwide and represents the most common cause of acute arthritis in the elderly. OBJECTIVES: To determine the incidence of both acute new onset or acute exacerbation of CIA among elderly patients hospitalized due to an acute medical illness. METHODS: This study comprised 85 patients...
March 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28405546/arthropathy-in-dermatology-a-comprehensive-review
#14
REVIEW
Soumya Jagadeesan, Padmanabha Shenoy
Dermatology and rheumatology are two specialties that deal with significant overlap. In this context, it is important that the dermatologists acquaint themselves with conditions presenting with arthropathy. As the first step, it is essential to know whether the origin of musculoskeletal symptom is articular or extra-articular; inflammatory or noninflammatory; acute or chronic; oligo- or poly-articular. This will help in narrowing down the differential diagnoses as well as in better correlation with the cutaneous symptoms...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28357052/recent-advances-in-understanding-and-managing-gout
#15
REVIEW
Talia F Igel, Svetlana Krasnokutsky, Michael H Pillinger
Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout and its associated conditions on patient morbidity and mortality. Unfortunately, gout remains under-diagnosed and under-treated in the general community. Despite major advances in treatment strategies, as many as 90% of patients with gout are poorly controlled or improperly managed and their hyperuricemia and recurrent flares continue...
2017: F1000Research
https://www.readbyqxmd.com/read/28356052/the-limitations-of-gram-stain-microscopy-of-synovial-fluid-in-concomitant-septic-and-crystal-arthritis
#16
Paul Stirling, Mohammed Tahir, Henry Dushan Atkinson
BACKGROUND: Rapid diagnosis of septic arthritis from Gram-stain microscopy is limited by an inherent false-negative rate of 25-78%. The presence of concomitant crystal arthritis in 5% of cases represents a particular diagnostic challenge. OBJECTIVE: This study aims to investigate the effects that a concomitant crystal arthropathy have on the ability of Gram-stain microscopy of synovial fluid to diagnose a septic arthritis. METHODS: This is a 12-year retrospective cohort study...
March 29, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28187026/an-algorithmic-approach-to-the-suspected-septic-wrist
#17
REVIEW
Jeffrey R Claiborne, Leslie G Branch, Michael Reynolds, Anthony J Defranzo
An acutely painful, erythematous wrist can be due to a variety of pathologic processes, including crystalline arthropathy, infection, trauma, osteoarthritis, and systemic disease. The broad differential diagnosis of the inflamed wrist and nonspecific clinical findings make accurate diagnosis challenging. There is no published clinical or laboratory criterion that reliably differentiates septic wrist arthritis from a sterile inflammatory arthropathy. For septic joint patients, long-term results are notably poorer in patients with a delay in treatment, therefore establishing evidenced-based guidelines deserves attention...
June 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27902172/is-it-easy-to-clinically-distinguish-inflammatory-arthritis-of-bacterial-origin-from-monoarthritis-attacks-of-gout-disease
#18
O Şahap Atik, Yılmaz Ergişi, Tacettin Ayanoğlu, Mehmet Ali Tokgöz, Erdem Aras Sezgin, Pınar Uyar Göçün
Acute monoarthritis is a common situation in orthopedic emergency where the patient presents with typical inflamed joint. It is hard to clinically distinguish inflammatory arthritis of bacterial origin from monoarthritis attacks of gout disease. If these two situations, which are the most common causes of acute monoarthritis, are misdiagnosed, outcomes might be catastrophic and costly. Synovial fluid analysis is the most reliable method for confirming the diagnosis although it might not always lead to definitive diagnosis...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27803833/coexistent-pseudogout-and-mycobacterium-avium-intracellulare-septic-arthritis-in-a-patient-with-hiv-and-esrd
#19
Wais Afzal, Omer M Wali, Kelly L Cervellione, Bhupinder B Singh, Farshad Bagheri
Pseudogout is a crystal-induced arthropathy characterized by the deposition of calcium pyrophosphate dihydrate (CPPD) crystals in synovial fluid, menisci, or articular cartilage. Although not very common, this entity can be seen in patients with chronic kidney disease (CKD). Septic arthritis due to Mycobacterium avium-intracellulare (MAI) is a rare entity that can affect immunocompromised patients such as those with acquired immunodeficiency syndrome (AIDS) or those who are on immunosuppressive drugs. Here, we describe a 51-year-old female who presented with fever, right knee pain, swelling, warmth, and decreased range of motion for several days...
2016: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/27742018/imaging-in-gout-and-other-crystal-related-arthropathies
#20
REVIEW
Patrick Omoumi, Pascal Zufferey, Jacques Malghem, Alexander So
In this article, the authors consider the manifestations of intraarticular and periarticular crystal deposits. Most cases of crystal deposits are asymptomatic and represent incidental findings at imaging. In symptomatic arthropathies, imaging can play an important role in the diagnosis and assessment of disease progression and the extent of crystal deposits. Conventional radiography is the most common imaging modality. But ultrasound, conventional computerized tomography (CT), dual-energy CT, and MRI play an increasing role...
November 2016: Rheumatic Diseases Clinics of North America
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