Chaohui Bao, Tingting Tan, Shan Wang, Chenxu Gao, Chang Lu, Siyue Yang, Yizhu Diao, Lulu Jiang, Duohui Jing, Liye Chen, Haitao Lv, Hai Fang
Cross-disease genome-wide association studies (GWASs) unveil pleiotropic loci, mostly situated within the non-coding genome, each of which exerts pleiotropic effects across multiple diseases. However, the challenge "W-H-W" (namely, whether, how, and in which specific diseases pleiotropy can inform clinical therapeutics) calls for effective and integrative approaches and tools. We here introduce a pleiotropy-driven approach specifically designed for therapeutic target prioritization and evaluation from cross-disease GWAS summary data, with its validity demonstrated through applications to two systems of disorders (neuropsychiatric and inflammatory)...
April 15, 2024: Cell Rep Methods