keyword
MENU ▼
Read by QxMD icon Read
search

accomplish study

keyword
https://www.readbyqxmd.com/read/29454148/-68-ga-galmydar-biodistribution-and-radiation-dosimetry-studies-in-rodents
#1
Jothilingam Sivapackiam, Richard Laforest, Vijay Sharma
INTRODUCTION: 68 Ga-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. 68 Ga-Galmydar excretes from blood pool quickly, and shows stable retention within rat myocardium in vivo for extended periods, therefore, the agent shows potential to enable myocardial perfusion imaging...
December 1, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29453621/response-preparation-response-selection-difficulty-and-response-outcome-learning
#2
Greg Huffman, Davood G Gozli, Bernhard Hommel, Jay Pratt
Voluntary action control is accomplished through anticipating that action's perceptual outcomes. Some evidence suggests that this is only true when responses are intention-based rather than stimulus-based and that this difference is evidence of different response modes. More recently, however, it has been shown that response-outcome retrieval effects can occur with stimulus-based responses, and that the retrieval depended on response selection efficiency as decreasing the response selection efficiency increased response-outcome retrieval (Gozli et al...
February 16, 2018: Psychological Research
https://www.readbyqxmd.com/read/29453565/sertoli-cell-preparation-for-co-immunoprecipitation
#3
Maria João Freitas, Margarida Fardilha
Most techniques to study protein-protein interactions, gene expression or signal transduction, among others, in Sertoli cells, depend on obtaining a protein extract of such cells. This is accomplished by lysing the Sertoli cells and solubilizing the intracellular proteins. Depending on the purpose of your study, the technique used to lyse and consequently obtain protein extracts from Sertoli cells must be considered. In this chapter, we will focus on how to obtain a protein Sertoli cell extract suitable for co-immunoprecipitation technique...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29452083/tribolium-castaneum-gene-expression-changes-after-paranosema-whitei-infection
#4
Alberto Lopez-Ezquerra, Andreas Mitschke, Erich Bornberg-Bauer, Gerrit Joop
BACKGROUND: Microsporidia are obligate parasites that possess some of the smallest eukaryotic genomes. Several insect species are susceptible to infections by microsporidian parasites. Paranosema whitei frequently infects young larvae of Tribolium castaneum and obligately kills the host whereupon transmission to subsequent hosts is accomplished via spores. P. whitei infection results in developmental arrest of T. castaneum, preventing larvae from pupation. The mechanisms underlying P...
February 13, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29451574/diastereoselective-synthesis-structure-and-reactivity-studies-of-ferrocenyloxazoline-gold-i-and-gold-ii-complexes
#5
Julia Holz, Marta Ayerbe García, Wolfgang Frey, Felix Krupp, René Peters
In the last few decades, gold complexes have demonstrated huge potential for soft Lewis acid catalysis. Despite the intensive research on Au complexes and planar chiral metallacycles, enantiopure ferrocenylgold complexes have - surprisingly - not been reported until the studies presented in this article. Herein, we report the asymmetric synthesis of planar chiral ferrocenyl Au(i) complexes. These dinuclear species form helically chiral ten-membered (NCCCAu) 2 rings stabilized by aurophilic interactions. In supramolecular solid state structures, linear, zigzag or helical Au(i) wires with regular AuAu separations were observed...
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29451362/simultaneous-multiple-ms-binding-assays-for-the-dopamine-norepinephrine-and-serotonin-transporters
#6
Patrick Neiens, Angela De Simone, Georg Höfner, Klaus T Wanner
In this work, we present label-free, mass-spectrometry-based binding assays (MS Binding Assays), targeting the human dopamine, norepinephrine, and serotonin transporters (hDAT, hNET, and hSERT) in simultaneous binding experiments. Using a validated LC-ESI-MS/MS method for quantification of the selective dopamine transporter inhibitor (R,R)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol ((R,R)-D-84), the selective norepinephrine transporter inhibitor (S,S)-reboxetine, and the selective serotonin reuptake inhibitor (S)-citalopram, binding affinities at the three monoamine transporters could be characterized simultaneously in a single binding experiment...
February 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29451225/quality-of-life-among-adolescents-aged-14-to-18-years-with-beta-thalassemia-major-tm-in-qatar
#7
Abdulqadir J Nashwan, Mohamed A Yassin, Ganga Devi J Babu, Sindhumole L K Nair, Izette L Libo-On, Hothaifah A Hijazi, Vincenzo De Sanctis, Ashraf Soliman
BACKGROUND: Thalassemia is a heterogeneous group of inherited disorders of hemoglobin synthesis. It is a common disease in Mediterranean, Southeast Asia, Indian subcontinent, and Middle East countries, including Qatar. PURPOSE: The aim of this study was to assess the quality of life (QOL) among patients aged 14 to 18 years with thalassemia major (TM) in Qatar and correlates their QOL with bio-demographic data of the patients compared to healthy controls. MATERIALS AND METHODS: This cross-sectional study measured the QOL in adolescents with thalassemia major who were attending ambulatory units in a tertiary hospital in Qatar...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29448408/energy-dissipation-in-a-friction-controlled-slide-of-a-body-excited-by-random-motions-of-the-foundation
#8
Sergey Berezin, Oleg Zayats
We study a friction-controlled slide of a body excited by random motions of the foundation it is placed on. Specifically, we are interested in such quantities as displacement, traveled distance, and energy loss due to friction. We assume that the random excitation is switched off at some time (possibly infinite) and show that the problem can be treated in an analytic, explicit, manner. Particularly, we derive formulas for the moments of the displacement and distance, and also for the average energy loss. To accomplish that we use the Pugachev-Sveshnikov equation for the characteristic function of a continuous random process given by a system of SDEs...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447136/individualized-neuropathic-pain-therapy-based-on-phenotyping-are-we-there-yet
#9
Julia Forstenpointner, Jan Otto, Ralf Baron
Patients with the same neuropathic pain disorder may have completely different sensory signs and symptoms yet receive the same medicinal treatment. New concepts suggest that patient stratification according to their pain mechanisms, reflected in their sensory phenotype, could be promising to implement an individualized therapy in neuropathic pain. Retrospective classification of patients according to their sensory phenotype showed predictive validity and reliability for treatment response in certain subgroups of patients...
March 2018: Pain
https://www.readbyqxmd.com/read/29446991/fluid-structure-interaction-modeling-of-aneurysmal-arteries-under-steady-state-and-pulsatile-blood-flow-a-stability-analysis
#10
Mohammadali Sharzehee, Seyed Saeid Khalafvand, Hai-Chao Han
Tortuous aneurysmal arteries are often associated with a higher risk of rupture but the mechanism remains unclear. The goal of this study was to analyze the buckling and post-buckling behaviors of aneurysmal arteries under pulsatile flow. To accomplish this goal, we analyzed the buckling behavior of model carotid and abdominal aorta with aneurysms by utilizing fluid-structure interaction (FSI) method with realistic waveforms boundary conditions. FSI simulations were done under steady-state and pulsatile flow for normal (1...
February 15, 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29445625/improvement-of-emergency-management-mechanism-of-public-health-crisis-in-rural-china-a-review-article
#11
REVIEW
Jiaxiang Hu, Chao Chen, Tingting Kuai
Background: With the rapid development of social economy in China, various public health emergencies frequently occur. Such emergencies cause a serious threat to human health and public safety, especially in rural China. Owing to flaws in emergency management mechanism and policy, the government is not capable to effectively deal with public health emergencies. Therefore, this study aimed to discuss the path to improve the emergency management mechanism for public health emergency in rural China...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29444715/porcine-wharton-s-jelly-cells-distribute-throughout-the-body-after-intraperitoneal-injection
#12
Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer, Duane L Davis
BACKGROUND: Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeutic effects. Most therapies require administering large numbers of cells and this is generally accomplished by intravenous injection. Here, we studied the locations of porcine WJCs in immune-competent, allogeneic hosts after intraperitoneal (IP) injection. METHODS: Male porcine WJCs were administered to female neonatal piglets by IP injection...
February 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29444479/prevalence-and-correlates-of-burnout-in-health-professionals-in-ecuador
#13
Marina R Ramírez, Patricia Otero, Vanessa Blanco, Mercy P Ontaneda, Olga Díaz, Fernando L Vázquez
BACKGROUND: Although burnout is a widespread phenomenon among healthcare professionals, there are no studies about its prevalence in Ecuador. This study assesses the prevalence of burnout syndrome among Ecuadorian healthcare professionals and examine the relationship with their personal and organizational characteristics. METHODS: A total of 2404 healthcare professionals (average age 40.0years; 68.4% women) from the capitals of all 24 provinces in Ecuador participated in this study...
December 5, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29442390/deciphering-the-biochemical-and-molecular-mechanism-underlying-the-in-vitro-and-in-vivo-chemotherapeutic-efficacy-of-ruthenium-quercetin-complex-in-colon-cancer
#14
Souvik Roy, Rituparna Das, Balaram Ghosh, Tania Chakraborty
Flavonoids are the most investigated phytochemicals due to their pharmacological and therapeutic activities. Their ability to chelate with metal ions has resulted in the emergence of a new category of molecules with a broader spectrum of pharmacological activities. In this study, the ruthenium quercetin complex has been synthesised and anticancer activity has been evaluated on a well-defined model of DMH followed by DSS induced rat colon cancer and on human colon cancer cell line HT-29. The characterizations accomplished through UV-visible, NMR, IR, Mass spectra and XRD techniques and antioxidant activity was assessed by DPPH, FRAP and ABTS methods...
February 14, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29441796/heart-failure-symptoms-profile-associated-with-depressive-symptoms
#15
Lucinda J Graven, Melinda K Higgins, Carolyn M Reilly, Sandra B Dunbar
Heart failure (HF) symptoms are known to influence depressive symptoms, yet a symptom profile has not been identified. HF symptoms relative to symptom experience (frequency, severity, interference with physical activity and enjoyment of life) associated with depressive symptoms were examined. Data from three HF studies ( N = 308) which used the Heart Failure Symptom Survey were included in this cross-sectional secondary analysis. Supervised classification for and identification of symptoms most associated with depressive symptoms were accomplished using random forest algorithms via conditional inference trees...
February 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29441344/implementation-of-a-sustainable-training-system-for-emergency-in-vietnam
#16
REVIEW
Sunjoo Kang, Hyejin Seo, Binh Duy Ho, Phuong Thi Anh Nguyen
Purpose: This study analyzed the project outcomes to share lessons regarding the development of an emergency medicine education system in Vietnam. Methods: Retrospective evaluation was implemented using project outcome indicators. Results: A total of 13 training courses were administered, with the collaboration of international experts in Korea and Vietnam. A total of 23 kinds of emergency medicine education equipment were purchased, and a basic life support (BLS) and two advanced cardiac life support labs were remodeled to provide appropriate simulation training...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29440567/cellular-and-molecular-mechanisms-of-centromere-drive
#17
Michael A Lampson, Ben E Black
The asymmetric outcome of female meiosis I, whereby an entire set of chromosomes are discarded into a polar body, presents an opportunity for selfish genetic elements to cheat the process and disproportionately segregate to the egg. Centromeres, the chromosomal loci that connect to spindle microtubules, could potentially act as selfish elements and "drive" in meiosis. We review the current understanding of the genetic and epigenetic contributions to centromere identity and describe recent progress in a powerful model system to study centromere drive in mice...
February 12, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29439721/real-time-fluorescence-loop-mediated-isothermal-amplification-assay-for-direct-detection-of-egg-drop-syndrome-virus
#18
Makay Zheney, Zhambul Kaziyev, Gulmira Kassenova, Lingna Zhao, Wei Liu, Lin Liang, Gang Li
BACKGROUND: Egg drop syndrome (EDS), caused by the adenovirus "egg drop syndrome virus" (EDSV) causes severe economic losses through reduced egg production in breeder and layer flocks. The diagnosis of EDSV has been done by molecular tools since its complete genome sequence was identified. In order to enhance the capabilities of the real-time fluorescence loop-mediated isothermal amplification (RealAmp) assay, we aimed to apply the method for direct detection of the EDSV without viral DNA extraction...
February 13, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29438294/first-diagnosed-case-of-camelpox-virus-in-israel
#19
Oran Erster, Sharon Melamed, Nir Paran, Shay Weiss, Yevgeny Khinich, Boris Gelman, Aharon Solomony, Orly Laskar-Levy
An outbreak of a disease in camels with skin lesions was reported in Israel during 2016. To identify the etiological agent of this illness, we employed a multidisciplinary diagnostic approach. Transmission electron microscopy (TEM) analysis of lesion material revealed the presence of an orthopox-like virus, based on its characteristic brick shape. The virus from the skin lesions successfully infected chorioallantoic membranes and induced cytopathic effect in Vero cells, which were subsequently positively stained by an orthopox-specific antibody...
February 13, 2018: Viruses
https://www.readbyqxmd.com/read/29436766/burnout-among-female-emergency-medicine-physicians-a-nationwide-study
#20
Atefeh Soltanifar, Elham Pishbin, Negin Attaran Mashhadi, Mona Najaf Najafi, Maryam Siahtir
OBJECTIVE: The challenging and stressful nature of emergency medicine place the practitioners of this young branch of medicine at risk of burnout. In Iran, the number of women choosing the specialty of emergency medicine has been increasing in recent years. No studies have focused on burnout among female emergency medicine physicians. We conducted this study to evaluate the level of burnout in female emergency medicine physicians in Iran. METHODS: In this cross-sectional study, all Iranian female emergency medicine physicians with more than 2 years of work experience as specialists, received a questionnaire containing 22-item Maslach Burnout Inventory scales and 7-item Cassidy social support scale, as well as questions about workload and career satisfaction...
February 13, 2018: Emergency Medicine Australasia: EMA
keyword
keyword
31270
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"