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https://www.readbyqxmd.com/read/28636031/attaining-resistive-switching-characteristics-and-selector-properties-by-varying-forming-polarities-in-a-single-hfo2-based-rram-device-with-a-vanadium-electrode
#1
Chih-Yang Lin, Po-Hsun Chen, Ting-Chang Chang, Kuan-Chang Chang, Sheng-Dong Zhang, Tsung-Ming Tsai, Chih-Hung Pan, Min-Chen Chen, Yu-Ting Su, Yi-Ting Tseng, Yao-Feng Chang, Ying-Chen Chen, Hui-Chun Huang, Simon M Sze
This study proposes a method for a HfO2-based device to exhibit both resistive switching (RS) characteristics as resistive random access memory (RRAM) and selector characteristics by introducing vanadium (V) as the top electrode. This simple V/HfO2/TiN structure can demonstrate these two different properties depending on forming polarities. The RS mechanism is activated by a positive forming bias. In contrast, the selector property is induced by a negative forming bias. The material analyses firstly confirm the existence of V in the top electrode...
June 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28634799/assessment-of-heat-inactivated-marine-aspergillus-flavus-as-a-novel-biosorbent-for-removal-of-cd-ii-hg-ii-and-pb-ii-from-water
#2
Mohamed E Mahmoud, Gehan M El Zokm, Aida E M Farag, Mohamed S Abdelwahab
A novel marine fungus was isolated and classified as Aspergillus flavus strain EGY11. The heat-inactivated form of isolated Aspergillus flavus was investigated and evaluated as a new eco-friendly and highly efficient biosorbent for removal of toxic heavy metals such as Cd(II), Hg(II), and Pb(II) from aqueous solutions. The SEM morphological studies of biosorbent-loaded metal ions confirmed their direct binding on the surface of heat-inactivated Aspergillus flavus. The metal biosorption capacity values were determined and optimized by the batch technique in the presence of various experimental controlling factors such as pH, contact time, biosorbent dosage, initial metal ion concentration, and coexisting species...
June 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634520/effect-of-heartfulness-meditation-on-burnout-emotional-wellness-and-telomere-length-in-health-care-professionals
#3
Jayaram Thimmapuram, Robert Pargament, Kedesha Sibliss, Rodney Grim, Rosana Risques, Erik Toorens
Background: Burnout poses significant challenges during training years in residency and later in the career. Meditation is a tool to treat stress-related conditions and promote wellness. Telomere length may be affected by burnout and stress. However, the benefits of meditation have not been fully demonstrated in health care professionals. Objective: We assessed the effects of a 12-week 'Heartfulness Meditation' program on burnout, emotional wellness, and telomere length in residents, faculty members, and nurses at a large community teaching hospital during the 2015-16 academic year...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28633172/burnout-and-depression-in-ms1-and-ms3-years-a-comparison-of-cohorts-at-one-medical-school
#4
Cinthia Elkins, Kyle P Plante, Lauren J Germain, Christopher P Morley
BACKGROUND: Losses of idealism, empathy, and professionalism over the course of medical education have been described previously in the literature. A 2012 national survey of medical students estimated 37%-44% with burnout, 58% screen positive for depression, and 9.4% with suicidal ideation in the past 12 months. Given changes in related traits, we sought to explore whether burnout and symptoms of depression change over time. The objectives of this study were to assess the differences in medical student burnout and symptoms of depression between first year (MS1) and third-year (MS3) medical students at one medical college...
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28633053/the-major-alternaria-alternata-allergen-alt-a-1-a-reliable-and-specific-marker-of-fungal-contamination-in-citrus-fruits
#5
M F Gabriel, N Uriel, F Teifoori, I Postigo, E Suñén, J Martínez
The ubiquitously present spores of Alternaria alternata can spoil a wide variety of foodstuffs, including a variety of fruits belonging to the Citrus genus. The major allergenic protein of A. alternata, Alt a 1, is a species-specific molecular marker that has been strongly associated with allergenicity and phytopathogenicity of this fungal species. This study aimed to evaluate the potential of the detection of Alt a 1 as a reliable indicator of A. alternata contamination in citrus fruits. To accomplish this aim, sixty oranges were artificially infected with a spore suspension of A...
June 8, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28632973/molecular-modeling-study-on-the-tubulin-binding-modes-of-epothilone-derivatives-insight-into-the-structural-basis-for-epothilones-activity
#6
Verónica A Jiménez, Joel B Alderete, Karen R Navarrete
Molecular dynamics (MD) simulations were employed to study the tubulin-binding modes of 20 epothilone derivatives spanning a wide range of antitumor activity. Trajectory analysis revealed that active ligands shared a common region of association and similar binding poses compared to the high-resolution crystal structure of the tubulin complex with epothilone A, the stathmin-like protein RB3, and tubulin tyrosine ligase (PDB code 4I50). Conformational analysis of epothilones in aqueous solution and tubulin-bound states indicated that the bound conformations of active species can be found to a significant extent within the ensemble of conformers available in aqueous solution...
June 20, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28632773/simulation-of-oak-early-life-history-and-interactions-with-disturbance-via-an-individual-based-model-soel
#7
Kenneth F Kellner, Robert K Swihart
Early tree life history and demography are driven by interactions with the environment such as seed predation, herbivory, light availability, and drought. For oak (Quercus) in the eastern United States, these interactions may contribute to oak regeneration failure. Numerous studies have examined the impact of individual factors (like seed predation) on the oak regeneration process, but less information is available on the relative and combined impacts of multiple intrinsic and extrinsic factors on early oak life history...
2017: PloS One
https://www.readbyqxmd.com/read/28632705/targeting-the-n-terminus-for-site-selective-protein-modification
#8
Christian B Rosen, Matthew B Francis
The formation of well-defined protein bioconjugates is critical for many studies and technologies in chemical biology. Tried-and-true methods for accomplishing this typically involve the targeting of cysteine residues, but the rapid growth of contemporary bioconjugate applications has required an expanded repertoire of modification techniques. One very powerful set of strategies involves the modification of proteins at their N termini, as these positions are typically solvent exposed and provide chemically distinct sites for many protein targets...
July 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28632547/a-less-invasive-retroperitoneal-lumbar-approach-animal-feasibility-study-and-primary-clinical-study
#9
Yu Qian, Zhen Lin, Cong Jin, Xing Zhao, Minghao Zheng
STUDY DESIGN: Surgical approach development in an animal model, and a prospective study comparing clinical outcomes between novel and conventional approaches in thoracolumbar burst fracture fixation. OBJECTIVE: To investigate the feasibility of a less-invasive retroperitoneal approach to the lumbar spine in a sheep model and to compare the clinical outcomes of anterior reconstruction in the treatment of thoracolumbar burst fractures using novel and conventional approaches...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632419/in-vitro-co-expression-of-human-amyloidogenic-immunoglobulin-light-and-heavy-chain-proteins-a-relevant-cell-based-model-of-al-amyloidosis
#10
Elena S Klimtchuk, Tatiana B Prokaeva, Brian H Spencer, Olga Gursky, Lawreen H Connors
Immunoglobulin (Ig) light chain (LC) amyloidosis (AL) is characterized by the overproduction and tissue deposition of monoclonal LC in various organs and tissues. The plasma circulating monoclonal LC is believed to be the precursor of the deposited protein and in vitro studies aimed at understanding AL pathobiology have mainly focused on LC and its variable domain. While 33% of patients have free circulating monoclonal LC, ∼40% feature LC complexed to heavy chain (HC) forming a monoclonal intact Ig; the significance of free vs...
June 20, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28629304/board-of-pharmacy-practices-related-to-medication-errors-and-their-potential-impact-on-patient-safety
#11
Daniel D Degnan, John B Hertig, Michael J Peters, James G Stevenson
State boards of pharmacy are generally responsible for the governance of the practice of pharmacy. While the regulatory process and methods for accomplishing this task may vary by state, all boards of pharmacy must address medication errors committed by pharmacists. The National Association of Boards of Pharmacy (NABP) has recommended that state boards of pharmacy implement best practices and enforcement actions that are aimed to promote patient safety and reduce medication errors. The current study was designed to identify and compare current corrective action practices among boards of pharmacy in response to medication errors...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28628838/validated-uplc-ms-ms-method-for-simultaneous-quantification-of-eight-saikosaponins-in-rat-plasma-application-to-a-comparative-pharmacokinetic-study-in-depression-rats-after-oral-administration-of-extracts-of-raw-and-vinegar-baked-bupleuri-radix
#12
Tianli Lei, Dandan Zhang, Kun Guo, Mingxiao Li, Chongning Lv, Jing Wang, Lingyun Jia, Jincai Lu
A sensitive and efficient UPLC-MS/MS method was developed and validated for simultaneous quantification of eight saikosaponins (SSa, SSb1, SSb2, SSb3, SSb4, SSc, SSd and SSf) in rat plasma. Furthermore, comparative pharmacokinetic profiles of these sakosaponins were investigated, following oral administration of extracts of raw and vinegar-baked Bupleuri Radix to depression rats. Biosamples were processed with liquid-liquid extraction technique using ethyl acetate. Chromatographic separation was accomplished on Waters BEH C18 UPLC column...
June 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28627929/design-of-the-hptn-065-tlc-plus-study-a-study-to-evaluate-the-feasibility-of-an-enhanced-test-link-to-care-plus-treat-approach-for-hiv-prevention-in-the-united-states
#13
Theresa Gamble, Bernard Branson, Deborah Donnell, H Irene Hall, Georgette King, Blayne Cutler, Shannon Hader, David Burns, Jason Leider, Angela Fulwood Wood, Kevin G Volpp, Kate Buchacz, Wafaa M El-Sadr
Background/Aims HIV continues to be a major public health threat in the United States, and mathematical modeling has demonstrated that the universal effective use of antiretroviral therapy among all HIV-positive individuals (i.e. the "test and treat" approach) has the potential to control HIV. However, to accomplish this, all the steps that define the HIV care continuum must be achieved at high levels, including HIV testing and diagnosis, linkage to and retention in clinical care, antiretroviral medication initiation, and adherence to achieve and maintain viral suppression...
June 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28627455/gemcitabine-vitamin-e-conjugates-synthesis-characterization-entrapment-into-nanoemulsions-and-in-vitro-deamination-and-antitumor-activity
#14
Ahmed Abu-Fayyad, Sami Nazzal
Gemcitabine is the first line therapy for pancreatic cancer. It is, however, extensively metabolized to the inactive form by deamination enzymatic reaction. Conjugation of gemcitabine with fatty acids on its 4-amino group was found to protect it from deamination deactivation reaction. The objective of the present study was to test the in-vitro anticancer activity of gemcitabine conjugated to the γ-tocotrienol isomer of vitamin E against pancreatic tumor cells. This objective was based on reported studies in which it was demonstrated that free tocotrienol isomers of vitamin E can potentiate the anticancer activity of gemcitabine...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28627120/new-insights-into-human-primordial-germ-cells-and-early-embryonic-development-from-single-cell-analysis
#15
REVIEW
Jörg Otte, Wasco Wruck, James Adjaye
Human preimplantation developmental studies are difficult to accomplish due to associated ethical and moral issues. Preimplantation cells are rare and exist only in transient cell states. From a single cell, it is very challenging to analyse the origination of the heterogeneity and complexity inherent to the human body. However, recent advances in single-cell technology and data analysis have provided new insights into the process of early human development and germ cell specification. In this Review, we examine the latest single-cell datasets of human preimplantation embryos and germ cell development, compare them to bulk cell analyses, and interpret their biological implications...
June 18, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28624473/antibody-blood-brain-barrier-efflux-is-modulated-by-glycan-modification
#16
John M Finke, Kari R Ayres, Ryan P Brisbin, Hali A Hill, Emily E Wing, William A Banks
BACKGROUND: Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on prior evidence, the hypothesis that glycan modification alters antibody blood-brain barrier permeability was tested here. METHODS: The blood-brain barrier permeability coefficient Pe of different glycosylated states of anti-amyloid IgG was measured using in vitro models of brain microvascular endothelial cells...
June 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28623588/design-of-knowledge-bases-for-plant-gene-regulatory-networks
#17
Eric Mukundi, Fabio Gomez-Cano, Wilberforce Zachary Ouma, Erich Grotewold
Developing a knowledge base that contains all the information necessary for the researcher studying gene regulation in a particular organism can be accomplished in four stages. This begins with defining the data scope. We describe here the necessary information and resources, and outline the methods for obtaining data. The second stage consists of designing the schema, which involves defining the entire arrangement of the database in a systematic plan. The third stage is the implementation, defined by actualization of the database by using software according to a predefined schema...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28621964/-the-best-interest-of-the-child-in-the-case-of-surrogate-maternity
#18
Ana-Paz Garibo Peyró
This article claims to analyze the situation of children born by means of surrogate maternity contract since these babies are one of the most vulnerable parts of this agreement, so their rights and interests could be affected in many ways. In order to study that situation, in the first place, has been accomplished a brief analysis of the concept of the best interest of the child. Afterwards it is examined the possible violation of the best interest of the child in the cases that have already been examined by Doctrine and Jurisprudence, that is, first the case of registration of these children in the country of origin Civil Registry of the intentional parents, and, in second place, the case of maternity benefit for intentional mothers...
May 2017: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28621883/determination-of-the-serine-palmitoyl-transferase-inhibitor-myriocin-by-electrospray-and-q-trap-mass-spectrometry
#19
Giuseppe Matteo Campisi, Paola Signorelli, Jessica Rizzo, Claudio Ghilardi, Jacopo Antognetti, Anna Caretti, Jelena S Lazarevic, Enrica Strettoi, Elena Novelli, Riccardo Ghidoni, Federico Maria Rubino, Rita Paroni
Myriocin, is a potent inhibitor of serine-palmitoyl-transferase, the first and rate-determining enzyme in the sphingolipids biosynthetic pathway. This study developed, validated and applied a LC-MS/MS method to measure Myriocin in minute specimens of animal tissue. The chemical analog 14-OH-Myriocin is used as the internal standard. The two molecules are extracted from the tissue homogenate by solid-phase extraction, separated by gradient reverse-phase liquid chromatography and measured by negative ion electrospray mass spectrometry in the triple quadrupole...
June 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28621369/transport-of-nanoparticles-across-pulmonary-surfactant-monolayer-a-molecular-dynamics-study
#20
Yan Xu, Li Deng, Hao Ren, Xianren Zhang, Fang Huang, Tongtao Yue
Pulmonary nanodrug delivery is an emerging concept, especially for targeted lung cancer therapy. Once inhaled, the nanoparticles (NPs) acting as drug carriers need to efficiently cross the pulmonary surfactant monolayer (PSM) of lung alveoli, which act as the first barrier for external particles entering the lung. Herein, by performing molecular dynamics simulations, we study how inhaled NPs interact with the PSM, particularly focusing on the transport of NPs with different properties across the PSM. While hydrophilic NPs translocate directly across the PSM, transport of hydrophobic NPs is achieved as the PSM wraps them...
June 16, 2017: Physical Chemistry Chemical Physics: PCCP
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