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https://www.readbyqxmd.com/read/29040538/immobilization-or-mobilization-after-iui-an-rct
#1
J van Rijswijk, M R Caanen, V Mijatovic, C G Vergouw, P M van de Ven, C B Lambalk, R Schats
STUDY QUESTION: Does 15 min of immobilization after IUI improve pregnancy rates? SUMMARY ANSWER: Immobilization for 15 min after IUI does not improve pregnancy rates. WHAT IS KNOWN ALREADY: Prior RCTs report a beneficial effect of supine immobilization for 15 min following IUI compared to immediate mobilization, however, these studies can be criticized. Given the importance for the logistics in daily practice and the lack of biological plausibility we planned a replication study prior to potential implementation of this procedure...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29036604/accomplishing-reform-successful-case-studies-drawn-from-the-health-systems-of-60-countries
#2
Jeffrey Braithwaite, Russell Mannion, Yukihiro Matsuyama, Paul Shekelle, Stuart Whittaker, Samir Al-Adawi, Kristiana Ludlow, Wendy James, Hsuen P Ting, Jessica Herkes, Louise A Ellis, Kate Churruca, Wendy Nicklin, Clifford Hughes
Healthcare reform typically involves orchestrating a policy change, mediated through some form of operational, systems, financial, process or practice intervention. The aim is to improve the ways in which care is delivered to patients. In our book 'Health Systems Improvement Across the Globe: Success Stories from 60 Countries', we gathered case-study accomplishments from 60 countries. A unique feature of the collection is the diversity of included countries, from the wealthiest and most politically stable such as Japan, Qatar and Canada, to some of the poorest, most densely populated or politically challenged, including Afghanistan, Guinea and Nigeria...
September 20, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29035946/role-of-the-lung-microbiome-in-hiv-pathogenesis
#3
Meera K Shenoy, Susan V Lynch
PURPOSE OF REVIEW: The purpose of this review is to summarize recent findings on the lung microbiome in HIV-infected patients and associated pulmonary diseases, and the relationship of airway microbial communities to metabolic and immune signatures within this patient population. RECENT FINDINGS: The lung microbiome in HIV infection is a relatively new and rapidly developing field; early studies in the field produced inconclusive evidence as to whether HIV-infection changes the lower airway microbiome...
October 14, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29035462/cpg-odn-stimulation-in-population-screening-monoclonal-b-cell-lymphocytosis
#4
Helena Podgornik, Petra Bajuk, Tadej Furlan, Hermina Cibej, Ana D Kebe, Peter Cernelc
BACKGROUND: Synthetic CpG-oligodeoxynucleotides (CpG-ODN) induce proliferation in normal and malignant lymphocytes B (LyB). This effect is widely exploited in CLL conventional chromosome banding analysis (CBA), which has become reliable only after the cultivation of CLL LyB using CpG-ODN stimulation in combination with IL-2. Monoclonal B-cell lymphocytosis (MBL) differs from CLL mainly in clone size. Only cytogenetic data on recurrent chromosomal aberrations analyzed by fluorescence in situ hybridization (FISH) are available for population screening MBL (sMBL)...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035065/serial-decision-making-in-monkeys-during-an-oculomotor-task
#5
Zachary M Abzug, Marc A Sommer
Much of everyday behavior involves serial decision-making, in which the outcome of 1 choice affects another. An example is setting rules for oneself: choosing a behavioral rule guides appropriate choices in the future. How the brain links decisions across time is poorly understood. Neural mechanisms could be studied in monkeys, as it is known that they can select and use behavioral rules, but existing psychophysical paradigms are poorly suited for the constraints of neurophysiology. Therefore, we designed a streamlined task that requires sequential, linked decisions, and trained 2 rhesus monkeys (Macaca mulatta) to perform it...
October 16, 2017: Journal of Experimental Psychology. Animal Learning and Cognition
https://www.readbyqxmd.com/read/29034498/design-synthesis-and-screening-of-triazolopyrimidine-pyrazole-hybrids-as-potent-apoptotic-inducers
#6
Raj Kamal, Vipan Kumar, Ravinder Kumar, Jitender K Bhardwaj, Priyanka Saraf, Priya Kumari, Vikas Bhardwaj
An efficient synthesis of novel 3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-5,7-dimethyl-[1,2,4]triazolo[4,3-a]-pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives bearing the pyrazole scaffold were screened to evaluate them as a reproductive toxicant in the testicular germ cells of goat (Capra hircus). This study aimed at assessing the cytological and biochemical changes in testicular germ cells after the exposure to triazolopyrimidines in a dose- and time-dependent manner...
October 16, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29034232/maternally-contributed-folate-receptor-1-is-expressed-in-ovarian-follicles-and-contributes-to-preimplantation-development
#7
Trine Strandgaard, Solveig Foder, Anders Heuck, Erik Ernst, Morten S Nielsen, Karin Lykke-Hartmann
Folates have been shown to play a crucial role for proper development of the embryo as folate deficiency has been associated with reduced developmental capacity such as increased risk of fetal neural tube defects and spontanous abortion. Transcripts encoding the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptor FOLR1 are expressed in oocytes and preimplantation embryos, respectively. In this study, we observed maternally contributed FOLR1 protein during mouse and human ovarian follicle development, and 2-cell mouse embryos...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29034092/choosing-the-uterine-preservation-surgery-for-placental-polyp-determined-by-blood-flow-evaluation-a-retrospective-cohort-study
#8
Sumire Sorano, Tatsuya Fukami, Maki Goto, Sakiko Imaoka, Miho Ando, Yoko To, Sumie Nakamura, Hiroko Yamamoto, Fuyuki Eguchi, Hiroshi Tsujioka
BACKGROUND: A placental polyp is an intrauterine polypoid mass or pedunculated mass occurring from residual trophoblastic tissue following abortion, cesarean section or vaginal delivery. Recently uterine preservation surgery represented by transcervical resection (TCR) has been performed for placental polyps. However TCR without intravascular intervention, including uterine artery embolization (UAE) may cause profound bleeding which necessitate emergency laparotomy. METHODS: Seventeen cases of placental polyp were retrospectively examined...
November 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29033081/a-cone-beam-computed-tomographic-study-of-apical-surgery-related-morphological-characteristics-of-the-distolingual-root-in-3-rooted-mandibular-first-molars-in-a-chinese-population
#9
Xiao Zhang, Ning Xu, Hanguo Wang, Qing Yu
INTRODUCTION: Apical surgery on the separate distolingual (DL) root of a 3-rooted mandibular first molar is thought to be difficult because DL roots are always severely curved, small, and shorter than distobuccal (DB) roots, and they are located far from the buccal cortical bone. The purpose of this study was to use cone-beam computed tomographic images to investigate the apical surgery-related morphological characteristics of DL roots in a Chinese population. METHODS: The screening process identified 83 subjects with 128 mandibular first molars with separate DL roots...
October 12, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29032640/deciphering-diversity-indices-for-better-understanding-of-the-microbial-communities
#10
REVIEW
Bo-Ra Kim, Jiwon Shin, Robin B Guevarra, Jun Hyung Lee, Doo Wan Kim, Kuk-Hwan Seol, Ju-Hoon Lee, Hyeun Bum Kim, Richard E Isaacson
The past decades have been a golden era when great tasks were accomplished in the field of microbiology including food microbiology. In the past, culture dependent methods have been the primary choice to investigate the bacterial diversity. However, using culture independent high throughput sequencing of 16S rRNA genes has greatly facilitated studies exploring the microbial compositions and dynamics associated with health and diseases. These culture independent DNA based studies generate large-scale data sets that describe the microbial composition of the certain niche...
October 14, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29032106/effect-of-monoamine-oxidase-inhibitors-on-ischaemia-reperfusion-induced-acute-kidney-injury-in-rats
#11
Hidenobu Tsutsui, Takaomi Shimokawa, Takeshi Miura, Masashi Takama, Toru Nishinaka, Tomoyuki Terada, Masayo Yamagata, Tokihito Yukimura
Increases in renal sympathetic nerve activity during ischaemia and renal venous norepinephrine levels after reperfusion play important roles in the development of ischaemia/reperfusion-induced acute kidney injury. In the present study, we examined the effect of isatin, an endogenous monoamine oxidase inhibitor, on renal venous norepinephrine levels, superoxide production after reperfusion, and ischaemia/reperfusion-induced acute kidney injury. Ischaemia/reperfusion-induced acute kidney injury was accomplished by clamping the left renal artery and vein for 45min, followed by reperfusion, 2 weeks after contralateral nephrectomy...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031999/analysis-of-biases-in-dynamic-margins-of-stability-introduced-by-the-use-of-simplified-center-of-mass-estimates-during-walking-and-turning
#12
Kathryn L Havens, Tatri Mukherjee, James M Finley
The ability to control the body's center of mass (CoM) is critical for preventing falls, which are a major health concern in aging populations. Control of the CoM has been assessed by characterizing dynamic margins of stability (MoS) which capture the dynamic relationship between the CoM and the base of support. Accurate estimation of CoM dynamics is best accomplished using a full-body marker set. However, a number of simplified estimates have been used throughout literature. Here, we determined the biases and sources of bias when computing MoS using four simplified CoM models, and we characterized how these biases varied in straight walking versus turning...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29031885/multiple-signal-amplification-via-ag-and-tio2-decorated-3d-nitrogen-doped-graphene-hydrogel-for-fabricating-sensitive-label-free-photoelectrochemical-thrombin-aptasensor
#13
Nan Hao, Rong Hua, Saibo Chen, Ying Zhang, Zhou Zhou, Jing Qian, Qian Liu, Kun Wang
In this study, Ag/TiO2/3D nitrogen doped graphene hydrogel (3DNGH) was prepared for the first time and the photocurrent intensity of this material was greatly enhanced, which was attributed to the multiple enhancements accomplished in one step. The porous structure of 3DNGH could provide an exceptionally large accessible surface area, which was beneficial for the anchoring of Ag and TiO2 nanoparticles. The introduction of nitrogen doped graphene and metal nanoparticles was capable to facilitate the charge separation efficiency and accelerate the transfer rate of the photogenerated electron-hole pairs...
October 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29031356/management-of-the-metabolic-acidosis-of-chronic-kidney-disease
#14
REVIEW
Nimrit Goraya, Donald E Wesson
Subjects with CKD and reduced glomerular filtration rate are at risk for chronic metabolic acidosis, and CKD is its most common cause. Untreated metabolic acidosis, even in its mildest forms, is associated with increased mortality and morbidity and should therefore be treated. If reduced glomerular filtration rate or the tubule abnormality causing chronic metabolic acidosis cannot be corrected, it is typically treated with dietary acid (H(+)) reduction using Na(+)-based alkali, usually NaHCO3. Dietary H(+) reduction can also be accomplished with the addition of base-producing foods such as fruits and vegetables and limiting intake of H(+)-producing foods like animal-sourced protein...
September 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29031320/burnout-and-its-relationship-with-personality-factors-in-oncology-nurses
#15
Emilia I De la Fuente-Solana, José L Gómez-Urquiza, Gustavo R Cañadas, Luis Albendín-García, Elena Ortega-Campos, Guillermo A Cañadas-De la Fuente
PURPOSE: To assess burnout levels in oncology nurses, to evaluate at what stage of burnout suffering they are and to analyze the relationship between burnout with personality factors. METHOD: A quantitative, observational, cross-sectional multicenter study was done. Oncology nurses (n = 101) from the Andalusian Health Service (Andalusia, Spain) were included. The main variables were personality factors, assessed with the NEO-FFI questionnaire, anxiety and depression, assessed with the Educational-Clinical Questionnaire: Anxiety and Depression, and burnout, evaluated with the Maslach Burnout Inventory...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29030435/dissociation-of-self-motion-and-object-motion-by-linear-population-decoding-that-approximates-marginalization
#16
Ryo Sasaki, Dora E Angelaki, Gregory C DeAngelis
We use visual image motion to judge the movement of objects, as well as our own movements through the environment. Generally, image motion components caused by object motion and self-motion are confounded in the retinal image. Thus, to estimate heading, the brain would ideally marginalize out the effects of object motion (or vice-versa), but little is known about how this is accomplished neurally. Behavioral studies suggest that vestibular signals play a role in dissociating object motion and self-motion, and recent computational work suggests that a linear decoder can approximate marginalization by taking advantage of diverse multisensory representations...
October 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29030175/characterization-of-the-pleiotropic-roles-of-sonic-hedgehog-during-retinal-regeneration-in-adult-zebrafish
#17
Jennifer L Thomas, Gregory W Morgan, Kaylee M Dolinski, Ryan Thummel
In contrast to the mammalian retina, the zebrafish retina possesses the ability to regenerate. This is primarily accomplished through Müller glial cells, which, upon damage, re-enter the cell cycle to form retinal progenitors. The progenitors continue to proliferate as they migrate to the area of damage and ultimately differentiate into new neurons. The purpose of this study was to characterize the expression and function of Sonic Hedgehog (Shh) during regeneration of the adult zebrafish retina. Expression profiling of Shh pathway genes showed a significant upregulation of expression associated with stages of progenitor proliferation and neuronal differentiation...
October 10, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29028357/folate-peg-nota-al18f-a-new-folate-based-radiotracer-for-pet-imaging-of-folate-receptor-positive-tumors
#18
Qingshou Chen, Xiangjun Meng, Paul McQuade, Daniel Rubins, Shu-An Lin, Zhizhen Zeng, Hyking Haley, Patricia Miller, Dinko Gonzalez Trotter, Philip S Low
The folate receptor (FR) has been established as a promising target for imaging and therapy of cancer (FR-α), inflammation, and autoimmune diseases (FR-β). Several folate-based PET radiotracers have been reported in the literature, but an 18F- labeled folate-PET imaging agent with optimal properties for clinical translation is still lacking. In the present study, we report the design and preclinical evaluation of folate-PEG12-NOTA-Al18F (1), a new folate-PET agent with improved potential for clinical applications...
October 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29028033/flat-top-surface-plasmon-polariton-beams
#19
Lauren Zundel, Rosario Martinez-Herrero, Alejandro Manjavacas
Surface plasmon polaritons (SPPs) have emerged as powerful tools for guiding and manipulating light below the diffraction limit. In this context, the availability of flat top SPP beams displaying a constant transversal profile can allow for uniform excitation and coupling scenarios, thus opening the door to developing novel applications that cannot be achieved using conventional Gaussian SPP beams. Here, we present a rigorous theoretical description of flat top SPP beams propagating along flat metal-dielectric interfaces...
October 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29027487/effect-of-tauroursodeoxycholic-acid-on-pufa-levels-and-inflammation-in-an-animal-and-cell-model-of-hepatic-endoplasmic-reticulum-stress
#20
M Aslan, E Kıraç, Ö Yılmaz, B Ünal, E K Konuk, F Özcan, H Tuzcu
The aim of this study was to evaluate hepatic polyunsaturated fatty acids (PUFAs) and inflammatory response in an animal and cell model of endoplasmic reticulum (ER) stress. Rats were divided into control, tunicamycin (TM)-treated, and TM + tauroursodeoxycholic acid (TUDCA)-treated groups. Hepatic ER stress was induced by TM and the ER stress inhibitor TUDCA was injected 30 min before induction of ER stress. Liver THLE-3 cells were treated with TM and TUDCA was administered in advance to decrease cytotoxic effects...
January 1, 2017: Human & Experimental Toxicology
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