keyword
MENU ▼
Read by QxMD icon Read
search

accomplish study

keyword
https://www.readbyqxmd.com/read/28230981/high-potency-phenylquinoxalinone-cystic-fibrosis-transmembrane-conductance-regulator-cftr-activators
#1
Jung-Ho Son, Jie S Zhu, Puay-Wah Phuan, Onur Cil, Andrew P Teuthorn, Colton K Ku, Sujin Lee, Alan S Verkman, Mark J Kurth
We previously identified phenylquinoxalinone CFTRact-J027 (4) as a cystic fibrosis transmembrane conductance regulator (CFTR) activator with an EC50 of ~200 nM, and demonstrated its therapeutic efficacy in mouse models of constipation. Here, structure-activity studies were done on 36 synthesized phenylquinoxalinone analogs to identify compounds with improved potency and altered metabolic stability. Synthesis of the phenylquinoxalinone core was generally accomplished by condensation of 1,2-phenylenediamines with substituted phenyloxoacetates...
February 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28230979/simple-expendable-3d-printed-microfluidic-systems-for-sample-preparation-of-petroleum
#2
Erica Megumi Kataoka, Rui Cesar Murer, Jandyson Machado Santos, Rogerio Mesquita de Carvalho, Marcos Nogueira Eberlin, Fabio Augusto, Ronei Jesus Poppi, Angelo Luiz Gobbi, Leandro Wang Hantao
In this study, we introduce a simple protocol to manufacture disposable, 3D-printed microfluidic systems for sample preparation of petroleum. Such platform is produced with a consumer-grade 3D-printer, using fused deposition modeling. Successful incorporation of solid-phase extraction (SPE) to microchip was ensured by facile 3D element integration using proposed approach. This 3D-printed μSPE device was applied to challenging matrices in oil & gas industry, such as crude oil and oil-brine emulsions. Case studies investigated important limitations of non-silicon and non-glass microchips, namely, resistance to nonpolar solvents and conservation of sample integrity...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230813/characterization-of-carbonic-anhydrase-9-in-the-alimentary-canal-of-aedes-aegypti-and-its-relationship-to-homologous-mosquito-carbonic-anhydrases
#3
Daniel P Dixon, Leslie Van Ekeris, Paul J Linser
In the mosquito midgut, luminal pH regulation and cellular ion transport processes are important for the digestion of food and maintenance of cellular homeostasis. pH regulation in the mosquito gut is affected by the vectorial movement of the principal ions including bicarbonate/carbonate and protons. As in all metazoans, mosquitoes employ the product of aerobic metabolism carbon dioxide in its bicarbonate/carbonate form as one of the major buffers of cellular and extracellular pH. The conversion of metabolic carbon dioxide to bicarbonate/carbonate is accomplished by a family of enzymes encoded by the carbonic anhydrase gene family...
February 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28230387/a-computer-adaptive-testing-version-of-the-addiction-severity-index-multimedia-version-asi-mv-the-addiction-severity-cat
#4
Stephen F Butler, Ryan A Black, Stacey A McCaffrey, Jessica Ainscough, Ann M Doucette
The purpose of this study was to develop and validate a computer adaptive testing (CAT) version of the Addiction Severity Index-Multimedia Version (ASI-MV), the Addiction Severity CAT. This goal was accomplished in 4 steps. First, new candidate items for Addiction Severity CAT domains were evaluated after brainstorming sessions with experts in substance abuse treatment. Next, this new item bank was psychometrically evaluated on a large nonclinical (n = 4,419) and substance abuse treatment (n = 845) sample. Based on these results, final items were selected and calibrated for the creation of the Addiction Severity CAT algorithms...
February 23, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28230007/laparoscopic-combined-with-percutaneous-ablation-for-hepatocellular-carcinoma-under-liver-capsule-a-single-chinese-center-experience-of-thirty-patients
#5
Zhe Tang, Yi Zhu, Kezhong Tang, Linping Dong, Bin Yang, Heqin Fang, Yulian Wu, Bo Zhang
AIM OF STUDY: For the tumor lesions close to capsule of the liver, traditional percutaneous radiofrequency ablation (PRFA) is limited due to high incidence of postoperative complications. The aim of the present study is to whether laparoscopic combined with PRFA (LCPR) could effectively ablate the tumor lesions close to capsule of the liver. METHODS: A total of 119 patients with subcapsular hepatocellular carcinoma (HCC) were divided into two groups: PRFA group (89 patients) and LCPR group (30 patients)...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229608/usefulness-of-an-intra-gastric-balloon-before-bariatric-surgery
#6
Cristina Vicente, Luis Ramón Rábago, Alejandro Ortega, Marisa Arias, Jaime Vázquez Echarri
INTRODUCTION: There are only few reports regarding the use of intragastric-balloons (IGB®) to achieve weight loss and subsequently decrease surgical complications. In this study, we try to assess whether presurgery weight loss using IGB decreases the postsurgical mortality after bariatric surgery. METHODS: This is a prospective case-control study. We matched 1:1 by gender, age (± 10 y-o) and type of surgery (sleeve resection [LSG] or gastric bypass [LGBP]), matching cases (A) and controls (H, from a historic cohort)...
23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28227499/promotion-and-guidance-of-neural-network-formation-on-su-8-photoresist-microchannels-adjusted-with-multilayer-films
#7
Yung-Chiang Liu, I-Chi Lee, Kin-Fong Lei, Yung-Chiang Liu, I-Chi Lee, Kin-Fong Lei, Yung-Chiang Liu, I-Chi Lee, Kin-Fong Lei
Induction of neural stem/progenitor cells (NSPCs) and establishment of neural network are important issues on neural engineering. In this work, a platform was designed to control and evaluate the differentiation of NSPCs, neurite direction, and to promote the neurite outgrowth. Polyelectrolyte multilayer (PEM) films provide surface properties by and have been used to regulate NSPCs differentiation in our previous study. Herein, a culture platform composed of SU-8 microchannel and PEM films was designed to achieve the goal of promoting NSPCs differentiation and to evaluate the effect of PEM films on the guidance of neural network formation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227373/comparative-study-of-texture-features-in-oct-images-at-different-scales-for-human-breast-tissue-classification
#8
Yu Gan, Xinwen Yao, Ernest Chang, Syed Bin Amir, Hanina Hibshoosh, Sheldon Feldman, Christine P Hendon, Yu Gan, Xinwen Yao, Ernest Chang, Syed Bin Amir, Hanina Hibshoosh, Sheldon Feldman, Christine P Hendon, Syed Bin Amir, Christine P Hendon, Sheldon Feldman, Yu Gan, Hanina Hibshoosh, Ernest Chang, Xinwen Yao
Breast cancer is the second leading cause of death in women in the United States due to cancer. Early detection of breast cancerous regions will aid the diagnosis, staging, and treatment of breast cancer. Optical coherence tomography (OCT), a non-invasive imaging modality with high resolution, has been widely used to visualize various tissue types within the human breast and has demonstrated great potential for assessing tumor margins. Imaging large resected samples with a fast imaging speed can be accomplished by under-sampling in the spatial domain, resulting in a large image scale...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226824/tunable-somatosensory-stimulation-for-selective-sleep-restriction-studies-in-rodents
#9
Dillon M Huffman, Kendra E Staggs, Farid Yaghouby, Anuj Agarwal, Bruce F O'Hara, Kevin D Donohue, Eric M Blalock, Sridhar Sunderam, Dillon M Huffman, Kendra E Staggs, Farid Yaghouby, Anuj Agarwal, Bruce F O'Hara, Kevin D Donohue, Eric M Blalock, Sridhar Sunderam, Eric M Blalock, Bruce F O'Hara, Kevin D Donohue, Kendra E Staggs, Sridhar Sunderam, Anuj Agarwal, Dillon M Huffman, Farid Yaghouby
Many methods for sleep restriction in rodents have emerged, but most are intrusive, lack fine control, and induce stress. Therefore, a versatile, non-intrusive means of sleep restriction that can alter sleep in a controlled manner could be of great value in sleep research. In previous work, we proposed a novel system for closed-loop somatosensory stimulation based on mechanical vibration and applied it to the task of restricting Rapid Eye Movement (REM) sleep in mice [1]. While this system was effective, it was a crude prototype and did not allow precise control over the amplitude and frequency of stimulation applied to the animal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226800/towards-direct-speech-synthesis-from-ecog-a-pilot-study
#10
Christian Herff, Garett Johnson, Lorenz Diener, Jerry Shih, Dean Krusienski, Tanja Schultz, Christian Herff, Garett Johnson, Lorenz Diener, Jerry Shih, Dean Krusienski, Tanja Schultz, Lorenz Diener, Christian Herff, Jerry Shih, Tanja Schultz, Dean Krusienski, Garett Johnson
Most current Brain-Computer Interfaces (BCIs) achieve high information transfer rates using spelling paradigms based on stimulus-evoked potentials. Despite the success of this interfaces, this mode of communication can be cumbersome and unnatural. Direct synthesis of speech from neural activity represents a more natural mode of communication that would enable users to convey verbal messages in real-time. In this pilot study with one participant, we demonstrate that electrocoticography (ECoG) intracranial activity from temporal areas can be used to resynthesize speech in real-time...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226771/multimodal-characterization-of-radiologically-detectable-lung-lesions
#11
Atasi Sarkar, A Sadhu, S Basu Thakur, S Sengupta, A Mukherjee, Jyotirmoy Chatterjee, Atasi Sarkar, A Sadhu, S Basu Thakur, S Sengupta, A Mukherjee, Jyotirmoy Chatterjee, S Basu Thakur, A Mukherjee, Atasi Sarkar, S Sengupta, A Sadhu, Jyotirmoy Chatterjee
Diagnosing radiologically detectable lung lesions on the basis of cyto/histopathological staining often suffers from ambiguity, leading to faulty detection of lung diseases, especially cancer. Present study attempted to perform a multimodal characterzation of clinical samples from patients with radiologically detected lung lesions, in order to classify diseases with higher precision. The study included analysing nuclear morphometric and intensity based differences between benign and malignant lung lesions in a quantitative way...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226017/-evaluation-of-psychosocial-care-centers-structure-in-the-region-of-m%C3%A3-dio-paraopeba-minas-gerais-brazil
#12
Sarah Nascimento Silva, Marina Guimarães Lima
OBJECTIVE: to evaluate the physical facilities, human resources and activities developed in the Psychosocial Care Centers (CAPS) in the region of Médio Paraopeba, Minas Gerais, Brazil, in 2014. METHODS: this is an evaluation study of the dimensions of structure and processes proposed by Donabedian, based on recommendations of the Ministry of Health and current laws; semi-structured forms were used to interview health managers; direct observation of mental health services was performed...
January 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28224937/telehealth-in-the-delivery-of-home-dialysis-care-catching-up-with-technology
#13
REVIEW
Vinay N Krishna, Kamesha Managadi, Michael Smith, Eric Wallace
Geographic and socioeconomic barriers may pose a significant difficulty in delivering home dialysis care to remote underserved populations leading to low utilization rates and poor outcomes. Telehealth may serve as a solution to overcome geographic barriers in delivering home dialysis care. Although technologic advances in telehealth have progressed rapidly making it accessible and inexpensive, it has been underused by nephrologists. Components of a regular face-to-face visit that can be successfully accomplished remotely using telehealth techniques include physician-patient communication, physical examination, laboratory and treatment data monitoring, nursing and nutrition education...
January 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28223497/architecture-and-coevolution-of-allosteric-materials
#14
Le Yan, Riccardo Ravasio, Carolina Brito, Matthieu Wyart
We introduce a numerical scheme to evolve functional elastic materials that can accomplish a specified mechanical task. In this scheme, the number of solutions, their spatial architectures, and the correlations among them can be computed. As an example, we consider an "allosteric" task, which requires the material to respond specifically to a stimulus at a distant active site. We find that functioning materials evolve a less-constrained trumpet-shaped region connecting the stimulus and active sites, and that the amplitude of the elastic response varies nonmonotonically along the trumpet...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28223457/the-source-and-evolutionary-history-of-a-microbial-contaminant-identified-through-soil-metagenomic-analysis
#15
Matthew R Olm, Cristina N Butterfield, Alex Copeland, T Christian Boles, Brian C Thomas, Jillian F Banfield
In this study, strain-resolved metagenomics was used to solve a mystery. A 6.4-Mbp complete closed genome was recovered from a soil metagenome and found to be astonishingly similar to that of Delftia acidovorans SPH-1, which was isolated in Germany a decade ago. It was suspected that this organism was not native to the soil sample because it lacked the diversity that is characteristic of other soil organisms; this suspicion was confirmed when PCR testing failed to detect the bacterium in the original soil samples...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28223178/direct-experimental-manipulation-of-intestinal-cells-in-ascaris-suum-with-minor-influences-on-the-global-transcriptome
#16
Bruce A Rosa, Samantha N McNulty, Makedonka Mitreva, Douglas P Jasmer
Ascaris suum provides a powerful model for studying parasitic nematodes, including individual tissues such as the intestine, an established target for anthelmintic treatments. Here, we add a valuable experimental component to our existing functional, proteomic, transcriptomic and phylogenomic studies of the Ascaris suum intestine, by developing a method to manipulate intestinal cell functions via direct delivery of experimental treatments (in this case, double-stranded (ds)RNA) to the apical intestinal membrane...
February 18, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28222424/1%C3%AE-25-oh-2d3-sensitive-cytosolic-ph-regulation-and-glycolytic-flux-in-human-endometrial-ishikawa-cells
#17
Ni Zeng, Yuetao Zhou, Shaqiu Zhang, Yogesh Singh, Bing Shi, Madhuri S Salker, Florian Lang
BACKGROUND/AIMS: Tumor cell proliferation is modified by 1,25-Dihydroxy-Vitamin D3 (1,25(OH)2D3), a steroid hormone predominantly known for its role in calcium and phosphorus metabolism. Key properties of tumor cells include enhanced glycolytic flux with excessive consumption of glucose and formation of lactate. As glycolysis is highly sensitive to cytosolic pH, maintenance of glycolysis requires export of H+ ions and lactate, which is in part accomplished by Na+/H+ exchangers, such as NHE1 and monocarboxylate transporters, such as MCT4...
February 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28222390/epr-and-photophysical-characterization-of-six-bioactive-oxidovanadium-iv-complexes-in-the-conditions-of-in-vitro-cell-tests
#18
Marta Lovisari, Giorgio Volpi, Domenica Marabello, Silvano Cadamuro, Annamaria Deagostino, Eliano Diana, Alessandro Barge, Margherita Gallicchio, Valentina Boscaro, Elena Ghibaudi
A number of oxidovanadium(IV) complexes have been reported to display anticancer activity. A theranostic approach, based on the simultaneous observation of both the effect of oxidovanadium(IV) complexes on cell viability and the disclosure of their intracellular fate, is possible by using oxidovanadium(IV) complexes functionalized with fluorescent ligands. In the present study we accomplished the characterization of six oxidovanadium(IV) complexes in conditions close to those employed for in vitro administration...
February 13, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28222351/the-land-morphology-approach-to-flood-risk-mapping-an-application-to-portugal
#19
N S Cunha, M R Magalhães, T Domingos, M M Abreu, C Küpfer
In the last decades, the increasing vulnerability of floodplains is linked to societal changes such as population density growth, land use changes, water use patterns, among other factors. Land morphology directly influences surface water flow, transport of sediments, soil genesis, local climate and vegetation distribution. Therefore, the land morphology, the land used and management directly influences flood risks genesis. However, attention is not always given to the underlying geomorphological and ecological processes that influence the dynamic of rivers and their floodplains...
February 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28222111/a-meta-analysis-of-the-abscopal-effect-in-preclinical-models-is-the-biologically-effective-dose-a-relevant-physical-trigger
#20
Raffaella Marconi, Silvia Strolin, Gianluca Bossi, Lidia Strigari
BACKGROUND: Preclinical in vivo studies using small animals are considered crucial in translational cancer research and clinical implementation of novel treatments. This is of paramount relevance in radiobiology, especially for any technological developments permitted to deliver high doses in single or oligo-fractionated regimens, such as stereotactic ablative radiotherapy (SABR). In this context, clinical success in cancer treatment needs to be guaranteed, sparing normal tissue and preventing the potential spread of disease or local recurrence...
2017: PloS One
keyword
keyword
31270
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"