keyword
MENU ▼
Read by QxMD icon Read
search

accomplish study

keyword
https://www.readbyqxmd.com/read/29227750/genetic-polymorphisms-in-prm1-prm2-and-ybx2-genes-are-associated-with-male-factor-infertility
#1
Oya Sena E Aydos, Yalda Hekmatshoar, Buket Altınok, Tülin Özkan, Onur Şakirağaoğlu, Aynur Karadağ, Fuat Kaplan, Seda Ilgaz, Mehmet Taşpınar, Işıl Yükselen, Asuman Sunguroğlu, Kaan Aydos
AIMS: The etiology of infertility is still unknown in almost half of all male infertility patients. In sperm, DNA condensation differs from somatic and female gamete cells, with the protamine (PRM) gene and its transcription factor, Y-box binding protein 2 (YBX2), playing key roles in making the structure more compact. Protamine polymorphisms have been studied in different populations, but various results have been acquired. MATERIALS AND METHODS: In our study, we examined, for the first time in a Turkish population, the association between protamine gene alleles (PRM1 c...
December 11, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29227108/visualizing-single-cell-secretion-dynamics-with-single-protein-sensitivity
#2
Matthew McDonald, André Gemeinhardt, Katharina König, Marek Piliarik, Stefanie Schaffer, Simon Völkl, Michael Aigner, Andreas Mackensen, Vahid Sandoghdar
Cellular secretion of proteins into the extracellular environment is an essential mediator of critical biological mechanisms, including cell-to-cell communication, immunological response, targeted delivery, and differentiation. Here, we report a novel methodology that allows for the real-time detection and imaging of single unlabeled proteins that are secreted from individual living cells. This is accomplished via interferometric detection of scattered light (iSCAT), and is demonstrated with Laz388 cells-an Epstein-Barr virus (EBV) transformed B cell line...
December 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/29226255/differential-hemispheric-and-visual-stream-contributions-to-ensemble-coding-of-crowd-emotion
#3
Hee Yeon Im, Daniel N Albohn, Troy G Steiner, Cody A Cushing, Reginald B Adams, Kestutis Kveraga
In crowds, where scrutinizing individual facial expressions is inefficient, humans can make snap judgments about the prevailing mood by reading "crowd emotion". We investigated how the brain accomplishes this feat in a set of behavioral and fMRI studies. Participants were asked to either avoid or approach one of two crowds of faces presented in the left and right visual hemifields. Perception of crowd emotion was improved when crowd stimuli contained goal-congruent cues and was highly lateralized to the right hemisphere...
2017: Nature Human Behaviour
https://www.readbyqxmd.com/read/29226151/in-vitro-in-silico-study-on-the-role-of-doubling-time-heterogeneity-among-primary-glioblastoma-cell-lines
#4
M-E Oraiopoulou, E Tzamali, G Tzedakis, A Vakis, J Papamatheakis, V Sakkalis
The application of accurate cancer predictive algorithms validated with experimental data is a field concerning both basic researchers and clinicians, especially regarding a highly aggressive form of cancer, such as Glioblastoma. In an aim to enhance prediction accuracy in realistic patient-specific environments, accounting for both inter- and intratumoral heterogeneity, we use patient-derived Glioblastoma cells from different patients. We focus on cell proliferation using in vitro experiments to estimate cell doubling times and sizes for established primary Glioblastoma cell lines...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225637/incidence-of-dentinal-crack-after-root-canal-preparation-by-protaper-universal-neolix-and-safesider-systems
#5
Azadeh Harandi, Sina Mirzaeerad, Mahgol Mehrabani, Elham Mahmoudi, Ali Bijani
Introduction: This study aimed to compare the incidence of dentinal crack formation by instrumentation with ProTaper Universal system (rotary, multi-file system), SafeSider (reciprocation movement, multi-file system) and Neolix (rotary, single-file system). Methods and Materials: In this in vitro study, 60 freshly extracted mandibular first molars were randomly divided into three experimental groups (n=15) and a control group containing unprepared teeth (n=15). Instrumentation in different groups was accomplished using either ProTaper, Neolix or SafeSider systems up to 25/0...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29225636/evaluation-of-the-prevalence-of-complete-isthmii-in-permanent-teeth-using-cone-beam-computed-tomography
#6
Sina Haghanifar, Ehsan Moudi, Zahrasadat Madani, Foroozan Farahbod, Ali Bijani
Introduction: The current study aimed at determining the prevalence of complete isthmii in permanent teeth, using cone-beam computed tomography (CBCT) in a selected Iranian community. Methods and Materials: In this cross sectional study, 100 CBCT images (from 58 female and 42 male patients) including 1654 teeth (809 maxillary and 845 mandibular teeth) were evaluated. Each tooth root was evaluated in axial plane (interval, 0.1 mm; thickness, 0.1 mm) from the orifice to the apex and from the apex to the orifice to detect the presence of complete isthmus...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29225482/the-relationship-between-empathy-and-burnout-lessons-for-paramedics-a-scoping-review
#7
REVIEW
Brett Williams, Rosalind Lau, Emma Thornton, Lauren S Olney
Background: The concepts of empathy and burnout are critical for practicing paramedics and the profession. While there has been an increasing body of research on the relationship between empathy and burnout with physicians and nurses, surprisingly, no research has been undertaken with paramedics. The aim of this scoping review was to explore the relationship between empathy and burnout. Method: A scoping review was performed based on Arskey and O'Malley's framework...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29224582/a-simple-preparation-method-for-full-range-electron-tomography-of-nanoparticles-and-fine-powders
#8
Elliot Padgett, Robert Hovden, Jessica C DaSilva, Barnaby D A Levin, John L Grazul, Tobias Hanrath, David A Muller
Electron tomography has become a valuable and widely used tool for studying the three-dimensional nanostructure of materials and biological specimens. However, the incomplete tilt range provided by conventional sample holders limits the fidelity and quantitative interpretability of tomographic images by leaving a "missing wedge" of unknown information in Fourier space. Imaging over a complete range of angles eliminates missing wedge artifacts and dramatically improves tomogram quality. Full-range tomography is usually accomplished using needle-shaped samples milled from bulk material with focused ion beams, but versatile specimen preparation methods for nanoparticles and other fine powders are lacking...
December 11, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/29223716/alkaline-degradation-of-lyophilized-dmsa-prior-to-labeling-with-99mtc-identification-and-development-of-the-degradation-pathway-by-hplc-and-ms
#9
Erika V Almeida, Samuel L De Brito
INTRODUCTION: Complexes of technetium-99m (99mTc) with meso-dimercaptosuccinic acid (DMSA) have been widely used as diagnostic agents in nuclear medicine. The degradation products (DP) of DMSA formed under different forced conditions have been identified through HPLC-DAD and LC-MSn studies. In this study, the DMSA kit was subjected to forced degradation under hydrolysis conditions as prescribed by the International Conference on Harmonization (ICH) guideline Q1A. METHODS: Chromatographic separation was accomplished on a reverse phase Shim-Pack VP-ODS (150 mm × 4...
November 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29222431/utilization-of-blood-by-products-an-in-silico-and-experimental-combined-study-for-bsa-usage
#10
Fátima Arrutia, Rebeca Fernández, Carlos Menéndez, Ulises A González, Francisco A Riera
In order to exploit industrial discards, protein enzymatic hydrolysis is a currently popular methodology for obtaining bioactive peptides. However, once released, most promising peptides have to be selected from the mixture. In this work, the suitability of pepsin (EC 3.4.23.1) to hydrolyse serum albumin in order to obtain bioactive peptides was assessed. Then, a suitable process to obtain best separation of bioactive peptides was evaluated, using polyethersulfone membranes at different pH values. Serum albumin was easily hydrolysed by pepsin, reaching a DH value of the 65...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222022/do-resident-case-logs-meet-acgme-requirements-a-comparison-between-acute-care-and-elective-cases
#11
Kathryn R Wolf, Zachary A Taylor, Sarah B Placek, Michael W Tsai, Brenton R Franklin, E Matthew Ritter
PURPOSE: Operative experience is at the core of general surgery residency, and recently operative volume requirements for graduating residents were increased. The ACGME has outlined 4 areas of required resident participation and documentation in order for a surgical case to be logged: determination or confirmation of the diagnosis, provision of preoperative care, selection and accomplishment of the operative procedure, and direction of the postoperative care. The purpose of this study was to examine whether general surgery residents are currently meeting the required care participation documentation standard and to examine the effect of acute care vs...
December 5, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29221981/chest-computed-tomography-image-for-accurately-predicting-the-optimal-insertion-depth-of-left-sided-double-lumen-tube
#12
Zhuo Liu, Li Zhao, Qianqian Jia, Xiaochun Yang, Shu Juan Liang, Wensheng He
OBJECTIVE: The main objective of this study was to assess the feasibility and accuracy of measuring the distance between the vocal cord and carina using chest computer tomography (CT) as a guide for the intubation of a left-sided double-lumen tube (LDLT). DESIGN: Single-center, prospective, randomized study. SETTING: Local hospital in China. PARTICIPANTS: Sixty adult patients undergoing elective thoracic surgery requiring an LDLT for one lung ventilation were enrolled in this study...
September 20, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29220352/how-do-slums-change-the-relationship-between-urbanization-and-the-carbon-intensity-of-well-being
#13
Julius Alexander McGee, Christina Ergas, Patrick Trent Greiner, Matthew Thomas Clement
This study examines how the relationship between urbanization (measured as the percentage of total population living in urban areas) and the carbon intensity of well-being (CIWB) (measured as a ratio of carbon dioxide emissions and life expectancy) in most nations from 1960-2013 varies based on the economic context and whereabouts of a substantial portion of a nation's urban population. To accomplish this, we use the United Nations' (UN) definition of slum households to identify developing countries that have substantial slum populations, and estimate a Prais-Winsten regression model with panel-corrected standard errors (PCSE), allowing for disturbances that are heteroskedastic and contemporaneously correlated across panels...
2017: PloS One
https://www.readbyqxmd.com/read/29218034/replication-of-staphylococcal-resistance-plasmids
#14
REVIEW
Stephen M Kwong, Joshua P Ramsay, Slade O Jensen, Neville Firth
The currently widespread and increasing prevalence of resistant bacterial pathogens is a significant medical problem. In clinical strains of staphylococci, the genetic determinants that confer resistance to antimicrobial agents are often located on mobile elements, such as plasmids. Many of these resistance plasmids are capable of horizontal transmission to other bacteria in their surroundings, allowing extraordinarily rapid adaptation of bacterial populations. Once the resistance plasmids have been spread, they are often perpetually maintained in the new host, even in the absence of selective pressure...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29217357/tempol-prevents-post-traumatic-stress-disorder-induced-memory-impairment
#15
Karem H Alzoubi, Abeer M Rababa'h, Omar N Yaqoub
Post-traumatic stress disorder (PTSD) is a mental health disorder that can develop after a terrifying or life threatening event. Multiple symptoms are noticed in patients with PTSD including cognitive impairment, which was shown to be is associated with oxidative stress. Tempol is a highly efficient membrane-permeable antioxidant. In this study, we investigated the possible protective effect of tempol on PTSD-induced memory impairment. To test this hypothesis, we used single prolonged stress (SPS) model (2h restrain, 20min forced swimming, 15min rest, and 1-2min diethyl ether exposure) as a model of PTSD...
December 4, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29216341/use-and-importance-of-nonhuman-primates-in-metabolic-disease-research-current-state-of-the-field
#16
Peter J Havel, Paul Kievit, Anthony G Comuzzie, Andrew A Bremer
Obesity and its multiple metabolic sequelae, including type 2 diabetes, cardiovascular disease, and fatty liver disease, are becoming increasingly widespread in both the developed and developing world. There is an urgent need to identify new approaches for the prevention and treatment of these costly and prevalent metabolic conditions. Accomplishing this will require the use of appropriate animal models for preclinical and translational investigations in metabolic disease research. Although studies in rodent models are often useful for target/pathway identification and testing hypotheses, there are important differences in metabolic physiology between rodents and primates, and experimental findings in rodent models have often failed to be successfully translated into new, clinically useful therapeutic modalities in humans...
December 5, 2017: ILAR Journal
https://www.readbyqxmd.com/read/29215063/reduced-vertical-displacement-of-the-center-of-mass-is-not-accompanied-by-reduced-oxygen-uptake-during-walking
#17
S R Wurdeman, P C Raffalt, N Stergiou
The six determinants of gait proposed that the goal of gait is to minimize vertical displacement of the body's center of mass (CoM) with the objective to optimize energy expenditure. On the contrary, recent investigations suggest that reduced vertical displacement leads to an increase in energy expenditure. However, these investigations had the included subjects deliberately changing their gait, which could bias the endpoint measures. The present study investigated the effect of reduced vertical displacement of the CoM on oxygen uptake and walking economy without imposing altered gait patterns...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214807/self-assembled-core-shell-cdte-poly-3-hexylthiophene-nanoensembles-as-novel-donor-acceptor-light-harvesting-systems
#18
Emin Istif, Antonia Kagkoura, Javier Hernández-Ferrer, Anastasios Stergiou, Theodosis Skaltsas, Raul Arenal, Ana M Benito, Wolfgang K Maser, Nikos Tagmatarchis
The self-assembly of novel core-shell nanoensembles consisting of regioregular poly(3-hexylthiophene) nanoparticles (P3HTNPs) of 100 nm as core and semiconducting CdTe quantum dots (CdTeQDs) as shell with a thickness of a few tens of nanometers was accomplished by employing a re-precipitation approach. The structure, morphology and composition of P3HTNPs/CdTeQDs nanoensembles were confirmed by high-resolution scanning transmission microscopy and dynamic light scattering studies. Intimate interface contact between the CdTeQDs shell and the P3HTNPs core leads to the stabilization of the P3HTNPs/CdTeQDs nanoensemble as probed by steady-state absorption spectroscopy...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29214598/evaluation-of-a-wireless-portable-wearable-multi-parameter-vital-signs-monitor-in-hospitalized-neurological-and-neurosurgical-patients
#19
Robert S Weller, Kristina L Foard, Timothy N Harwood
Unrecognized changes in patients' vital signs can result in preventable deaths in hospitalized patients. Few publications or studies instituting routine patient monitoring have described implementation and the setting of alarm parameters for vital signs. We wanted to determine if continuous multi-parameter patient monitoring can be accomplished with an alarm rate that is acceptable to hospital floor nurses and to compare the rate of patient deterioration events to those observed with routine vital sign monitoring...
December 6, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29213305/a-multiplexed-magnetic-tweezer-with-precision-particle-tracking-and-bi-directional-force-control
#20
Keith C Johnson, Emilie Clemmens, Hani Mahmoud, Robin Kirkpatrick, Juan C Vizcarra, Wendy E Thomas
Background: In the past two decades, methods have been developed to measure the mechanical properties of single biomolecules. One of these methods, Magnetic tweezers, is amenable to aquisition of data on many single molecules simultaneously, but to take full advantage of this "multiplexing" ability, it is necessary to simultaneously incorprorate many capabilities that ahve been only demonstrated separately. Methods: Our custom built magnetic tweezer combines high multiplexing, precision bead tracking, and bi-directional force control into a flexible and stable platform for examining single molecule behavior...
2017: Journal of Biological Engineering
keyword
keyword
31270
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"