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https://www.readbyqxmd.com/read/27924403/diversity-and-abundance-of-the-denitrifying-microbiota-in-the-sediment-of-eastern-china-marginal-seas-and-the-impact-of-environmental-factors
#1
Minghong Gao, Jiwen Liu, Yanlu Qiao, Meixun Zhao, Xiao-Hua Zhang
Investigating the environmental influence on the community composition and abundance of denitrifiers in marine sediment ecosystem is essential for understanding of the ecosystem-level controls on the biogeochemical process of denitrification. In the present study, nirK-harboring denitrifying communities in different mud deposit zones of eastern China marginal seas (ECMS) were investigated via clone library analysis. The abundance of three functional genes affiliated with denitrification (narG, nirK, nosZ) was assessed by fluorescent quantitative PCR...
December 6, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27924114/total-synthesis-of-%C3%A2-naphthacemycin-a9-possessing-both-antibacterial-activity-against-methicillin-resistant-staphylococcus-aureus-and-circumventing-effect-of-%C3%AE-lactam-resistance
#2
Tomoyasu Hirose, Yasuhiro Kojima, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Kazuro Shiomi, Satoshi Ōmura, Toshiaki Sunazuka
The total synthesis of KB-3346-5A9, named naphthacemycin A9, has been accomplished by combining the Dötz reaction and Suzuki-Miyaura cross coupling as well as employing Friedel-Crafts reaction with dienone-phenol rearrangement as key steps. We also describe the preparation of the simplified tetarimycin A and naphthacemycin A analogs as a model study, which coincidentally reveal unique properties of naturally occurring naphthacene-5,6,11(12H)-trione framework. The synthesized compounds were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus (VRE) to elucidate their structure-activity relationships (SARs), the results of which agreed with a previously reported preliminary SAR study of tetarimycin A...
December 7, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27922934/psychometric-properties-of-the-chinese-version-of-the-menopause-specific-quality-of-life-questionnaire
#3
Guangning Nie, Hongyan Yang, Jian Liu, ChunMei Zhao, Xiaoyun Wang
OBJECTIVE: The Menopause-Specific Quality-of-Life (MENQOL) questionnaire was developed as a specific tool to measure the health-related quality-of-life of postmenopausal women. Thus far, the Chinese version questionnaire has not been subjected to psychometric assessment with a large sample. This study aims to evaluate the validity and reliability of the Chinese version of the MENQOL specific to postmenopausal women in China. METHODS: A total of 1,137 menopausal symptomatic and 491 menopausal asymptomatic women from eight cities in China were recruited using a convenience sampling method...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922518/hepatitis-c-point-of-care-testing-in-vulnerable-populations-a-human-factors-study
#4
Donna M Zucker, Akshaya Shanmugam
One third of all hepatitis C virus (HCV) cases in the United States are incarcerated in jails and prisons. Hepatitis C virus testing is primarily accomplished through a clinical laboratory, yet point-of-care (POC) testing is less invasive and results are available in 20 minutes compared with up to 3 weeks. The purpose of this article was to describe the findings of a collaborative project between the Colleges of Engineering and Nursing at the University of Massachusetts Amherst in executing a human factors study for HCV antibody testing and screening...
November 2016: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/27919006/assessment-of-the-risk-of-foodborne-transmission-and-burden-of-hepatitis-e-in-switzerland
#5
Alexandra Müller, Lucie Collineau, Roger Stephan, Andrea Müller, Katharina D C Stärk
The objective of this study was i) to quantify the risk of hepatitis E for Swiss consumers by specified pork products and ii) to estimate the total burden of human food-borne hepatitis E in Switzerland. A quantitative risk assessment from slaughter to consumption was carried out according to the Codex Alimentarius framework. In the hazard characterization, assumptions were made due to the lack of a dose-response relationship for oral exposure to hepatitis E virus (HEV). The prevalence of HEV in 160 pig livers of 40 different Swiss fattening farms was examined and determined to be 1...
November 22, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27918696/validation-of-inertial-measurement-units-for-upper-body-kinematics
#6
Melissa M B Morrow, Bethany Lowndes, Emma Fortune, Kenton R Kaufman, Susan Hallbeck
The purpose of this study was to validate a commercially available IMU system against a standard lab-based motion capture system for the measurement of shoulder elevation, elbow flexion, trunk flexion/extension and neck flexion/extension kinematics. The validation analyses were applied to six surgical faculty members performing a standard, simulated surgical training task that mimics minimally invasive surgery. Three-dimensional joint kinematics were simultaneously recorded by an optical motion capture system and an IMU system with six sensors placed on the head, chest, and bilateral upper and lower arms...
December 5, 2016: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/27917575/efficacy-and-tolerability-of-a-new-topical-nitric-zinc-preparation-for-difficult-to-treat-warts
#7
Camila K Janniger, Robert A Schwartz
Treating plantar, periungual, and external genital warts can be challenging. A prospective study from four centers in Italy evaluated 37 immunocompetent patients with single or multiple warts and treated each lesion with a nitric-zinc topical solution composed of organic and inorganic acids meant to devitalize tissue and destroy HPV DNA in infected keratinocytes. Thirty of the 37 patients had external genital warts, two had plantar warts, two had palm and finger warts, and three had subungual warts for a total of 55 lesions treated...
December 5, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27916460/the-upregulation-of-pro-inflammatory-cytokines-in-the-rabbit-uterus-under-the-lipopolysaccaride-induced-reversible-immunoresponse-state
#8
S J Liu, Y Shi, C Liu, M Zhang, Z C Zuo, C J Zeng, G B Zhou, H Xian, T Z Song
The reproductive organs are more likely to develop gram-negative bacterial infection than other internal organs because of direct access to the body surface. The objective of this study was (1) to provide a suitable intravenous injection dose of lipopolysaccharides (LPS) instead of gram-negative bacterial infection in order to induce a reversible immunoresponse state and (2) to examine the expression levels of pro-inflammatory cytokines in the uterus of rabbits while in an immunoresponse state. Two series of experiments were performed to accomplish these objectives...
November 29, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27916416/dosimetric-feasibility-of-ablative-dose-escalated-focal-monotherapy-with-mri-guided-high-dose-rate-hdr-brachytherapy-for-prostate-cancer
#9
Ali Hosni, Marco Carlone, Alexandra Rink, Cynthia Ménard, Peter Chung, Alejandro Berlin
PURPOSE: To determine the dosimetric feasibility of dose-escalated MRI-guided high-dose-rate brachytherapy (HDR-BT) focal monotherapy for prostate cancer (PCa). METHODS: In all patients, GTV was defined with mpMRI, and deformably registered onto post-catheter insertion planning MRI. PTV included the GTV plus 9mm craniocaudal and 5mm in every other direction. In discovery-cohort, plans were obtained for each PTV independently aiming to deliver ⩾16.5Gy/fraction (two fraction schedule) while respecting predefined organs-at-risk (OAR) constraints or halted when achieved equivalent single-dose plan (24Gy)...
December 1, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27916109/diversity-matters-in-academic-radiology-acknowledging-and-addressing-unconscious-bias
#10
Brenda J Allen, Kavita Garg
To meet challenges related to changing demographics, and to optimize the promise of diversity, radiologists must bridge the gap between numbers of women and historically underrepresented minorities in radiology and radiation oncology as contrasted with other medical specialties. Research reveals multiple ways that women and underrepresented minorities can benefit radiology education, research, and practice. To achieve those benefits, promising practices promote developing and implementing strategies that support diversity as an institutional priority and cultivate shared responsibility among all members to create inclusive learning and workplace environments...
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27914356/can-podcasts-for-assessment-guidance-and-feedback-promote-self-efficacy-among-undergraduate-nursing-students-a-qualitative-study
#11
Linda C McSwiggan, Maureen Campbell
BACKGROUND: Improving assessment guidance and feedback for students has become an international priority within higher education. Podcasts have been proposed as a tool for enhancing teaching, learning and assessment. However, a stronger theory-based rationale for using podcasts, particularly as a means of facilitating assessment guidance and feedback, is required. OBJECTIVE: To explore students' experiences of using podcasts for assessment guidance and feedback...
November 27, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27913395/metabolomic-characterization-of-hepatocellular-carcinoma-in-patients-with-liver-cirrhosis-for-biomarker-discovery
#12
Cristina Di Poto, Alessia Ferrarini, Yi Zhao, Rency S Varghese, Chao Tu, Yiming Zuo, Minkun Wang, Mohammad R Nezami Ranjbar, Yue Luo, Chi Zhang, Chirag S Desai, Kirti Shetty, Mahlet G Tadesse, Habtom W Ressom
BACKGROUND: Metabolomics plays an important role in providing insight into the etiology and mechanisms of hepatocellular carcinoma (HCC). This is accomplished by a comprehensive analysis of patterns involved in metabolic alterations in human specimens. This study compares the levels of plasma metabolites in HCC cases versus cirrhotic patients and evaluates the ability of candidate metabolites in distinguishing the two groups. Also, it investigates the combined use of metabolites and clinical covariates for detection of HCC in patients with liver cirrhosis...
December 2, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27913144/effect-of-o-glcnacylation-on-hnrnp-a1-translocation-and-interaction-with-transportin1
#13
Shira Roth, Isam Khalaila
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a major pre-mRNA binding protein involved in transcription and translation. Although predominantly nuclear, hnRNP A1 shuttles rapidly between the nucleus and the cytosol, delivering its anchored pre-mRNA for further processing. Translocation is important for hnRNP A1 to accomplish its transcriptional and translational roles. Transportin1 (Trn1), a translocation protein, facilitates the translocation of hnRNP A1 back to the nucleus. Moreover, phosphorylation of serine residues at hnRNP A1 C-terminal domain affects its translocation...
November 29, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27912973/micro-ureteroscopy-for-the-treatment-of-distal-ureteral-calculi-in-children
#14
Mehmet Mazhar Utanğaç, Ahmet Ali Sancaktutar, Abdulkadir Tepeler
OBJECTIVE: The objective of this study was to demonstrate the efficacy and safety of micro-ureteroscopy (micro-URS) in the management of distal ureteral stones in the pediatric population. MATERIALS AND METHODS: A total of 11 children, who had undergone micro-URS between September 2015 and April 2016 with the indication of distal ureteral calculi in two referral centers, were retrospectively evaluated. The procedures were performed with the patient in the lithotomy position under general anesthesia using the standard URS technique with a micro-ureteroscope that has a caliber of 4...
November 17, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27911938/motion-plan-changes-predictably-in-dyadic-reaching
#15
Atsushi Takagi, Niek Beckers, Etienne Burdet
Parents can effortlessly assist their child to walk, but the mechanism behind such physical coordination is still unknown. Studies have suggested that physical coordination is achieved by interacting humans who update their movement or motion plan in response to the partner's behaviour. Here, we tested rigidly coupled pairs in a joint reaching task to observe such changes in the partners' motion plans. However, the joint reaching movements were surprisingly consistent across different trials. A computational model that we developed demonstrated that the two partners had a distinct motion plan, which did not change with time...
2016: PloS One
https://www.readbyqxmd.com/read/27911875/autophagy-flux-induced-by-ginsenoside-rg3-attenuates-human-prion-protein-mediated-neurotoxicity-and-mitochondrial-dysfunction
#16
Ji-Hong Moon, Ju-Hee Lee, You-Jin Lee, Sang-Youel Park
Mitochondrial quality control is a process by which mitochondria undergo successive rounds of fusion and fission with dynamic exchange of components to segregate functional and damaged elements. Removal of mitochondrion that contains damaged components is accomplished via autophagy. In this study, we investigated whether ginsenoside Rg3, an active ingredient of the herbal medicine ginseng that is used as a tonic and restorative agent, could attenuate prion peptide, PrP (106-126)-induced neurotoxicity and mitochondrial damage...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27910501/multicharged-carbon-ion-generation-from-laser-plasma
#17
Oguzhan Balki, Hani E Elsayed-Ali
Carbon ions generated by ablation of a carbon target using an Nd:YAG laser pulse (wavelength λ = 1064 nm, pulse width τ = 7 ns, and laser fluence of 10-110 J cm(-2)) are characterized. Time-of-flight analyzer, a three-mesh retarding field analyzer, and an electrostatic ion energy analyzer are used to study the charge and energy of carbon ions generated by laser ablation. The dependencies of the ion signal on the laser fluence, laser focal point position relative to target surface, and the acceleration voltage are described...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910129/synthesis-of-c-14-radiolabeled-glucagon-receptor-antagonist-and-its-use-in-a-human-mass-balance-study
#18
Boris A Czeskis, Darlene K Satonin
The synthesis of the radiolabeled glucagon receptor antagonist 1-[(14) C] was accomplished based on decarboxylative iodination of acid 2 followed by "reattachment" of (14) C carboxylic function. The method allowed a significant reduction in the number of steps in preparation of the radiolabeled compound. Iodide 4, obtained by the halodecarboxylation, was converted to cyanide 5-[(14) C], which was hydrolyzed to provide the radiolabeled acid 2-[(14) C]. Coupling with β-alanine fragment and hydrolysis of ester 6-[(14) C] completed the synthesis of the target molecule 1-[(14) C]...
December 1, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27909815/homoeologous-recombination-in-the-presence-of-ph1-gene-in-wheat
#19
Dal-Hoe Koo, Wenxuan Liu, Bernd Friebe, Bikram S Gill
A crossover (CO) and its cytological signature, the chiasma, are major features of eukaryotic meiosis. The formation of at least one CO/chiasma between homologous chromosome pairs is essential for accurate chromosome segregation at the first meiotic division and genetic recombination. Polyploid organisms with multiple sets of homoeologous chromosomes have evolved additional mechanisms for the regulation of CO/chiasma. In hexaploid wheat (2n = 6× = 42), this is accomplished by pairing homoeologous (Ph) genes, with Ph1 having the strongest effect on suppressing homoeologous recombination and homoeologous COs...
December 1, 2016: Chromosoma
https://www.readbyqxmd.com/read/27909777/quantitative-determination-of-the-neurotoxin-%C3%AE-n-methylamino-l-alanine-bmaa-by-capillary-electrophoresis-tandem-mass-spectrometry
#20
Elliott S Kerrin, Robert L White, Michael A Quilliam
Recent reports of the widespread occurrence of the neurotoxin β-N-methylamino-L-alanine (BMAA) in cyanobacteria and particularly seafood have raised concerns for public health. LC-MS/MS is currently the analytical method of choice for BMAA determinations but incomplete separation of isomeric and isobaric compounds, matrix suppression and conjugated forms are plausible limitations. In this study, capillary electrophoresis (CE) coupled with MS/MS has been developed as an alternative method for the quantitative determination of free BMAA...
December 1, 2016: Analytical and Bioanalytical Chemistry
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